Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents
score: 3.6628656, Bioorganic & Medicinal Chemistry Letters, 2012, Zheng, Chang-Ji et. al.
Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents
score: 3.6628656, Bioorganic & Medicinal Chemistry Letters, 2012, Zheng, Chang-Ji et. al.
Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents
score: 3.4967412, Bioorganic & Medicinal Chemistry Letters, 2012, Zheng, Chang-Ji et. al.
Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer
score: 3.4710488, Bioorganic & Medicinal Chemistry, 2006, Narayanasamy, Sureshbabu et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 3.4559426, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
score: 3.3117583, Bioorganic & Medicinal Chemistry, 2012, El-Sayed, Magda A.-A. et. al.
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
score: 3.3117583, Bioorganic & Medicinal Chemistry, 2012, El-Sayed, Magda A.-A. et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 3.2832079, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
Synthesis of (bis)Sulfonic acid, (bis)Benzamides as follicle-Stimulating hormone (FSH) antagonists
score: 3.2670747, Bioorganic & Medicinal Chemistry, 2002, Wrobel, Jay et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.2299842, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring
score: 3.2054235, European Journal of Medicinal Chemistry, 2003, Balsamo, Aldo et. al.
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors
score: 3.20411, Bioorganic & Medicinal Chemistry Letters, 2012, Ghosh, Arun K. et. al.
Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method
score: 3.2009278, European Journal of Medicinal Chemistry, 2006, Michaux, Catherine et. al.
Structure-activity relationships of cyclic enediynes related to dynemicin A—I. Synthesis and antitumor activity of 9-acetoxy enediynes equipped with aryl carbamate moieties
score: 3.1826276, Bioorganic & Medicinal Chemistry, 1997, Unno, Ryoichi et. al.
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
score: 3.1756367, Bioorganic & Medicinal Chemistry, 2012, El-Sayed, Magda A.-A. et. al.
Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template
score: 3.1584757, Bioorganic & Medicinal Chemistry, 2003, Hirayama, Fukushi et. al.
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors
score: 3.1545585, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents
score: 3.1541944, Bioorganic & Medicinal Chemistry Letters, 2013, Abuhaie, Cristina-Maria et. al.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 3.1488835, Bioorganic & Medicinal Chemistry Letters, 2012, Arasappan, Ashok et. al.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 3.1488835, Bioorganic & Medicinal Chemistry Letters, 2012, Arasappan, Ashok et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.1475443, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.1475443, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.1475443, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors
score: 3.145511, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors
score: 3.145511, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold
score: 3.1385797, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold
score: 3.1385797, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold
score: 3.1385797, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors
score: 3.128727, Bioorganic & Medicinal Chemistry, 2006, Anana, Raymond et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.1221269, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.1221269, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.1221269, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: New isoform-I selective nanomolar inhibitors
score: 3.1039262, Bioorganic & Medicinal Chemistry Letters, 2012, Sechi, Mario et. al.
Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)
score: 3.0748009, Bioorganic & Medicinal Chemistry, 2006, Chen, Qiao-Hong; Praveen Rao, P.N.; Knaus, Edward E.
Design, Synthesis and Structure-Activity-Relationship of 1,5-Tetrahydronaphthyridines as CETP Inhibitors
score: 3.0737728, Bioorganic & Medicinal Chemistry Letters, 2012, Fernandez, Maria-Carmen et. al.
Development of a new class of aromatase inhibitors: Design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives
score: 3.0736968, Bioorganic & Medicinal Chemistry, 2012, Bonfield, Kevin et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.0657998, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 3.0634226, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 3.0634226, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs
score: 3.0508715, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs
score: 3.0508715, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs
score: 3.0508715, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.
score: 3.0475337, Antimicrobial agents and chemotherapy, 2004, Chen, D et. al.
Lead Optimization of Purine Based Orally Bioavailable Mps1 (TTK) inhibitors
score: 3.0307992, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents
score: 3.0207422, Bioorganic & Medicinal Chemistry, 2012, Özadalı, Keriman et. al.
3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases
score: 3.0042502, Bioorganic & Medicinal Chemistry, 2005, Thaimattam, Ram et. al.
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists
score: 3.00308, European Journal of Medicinal Chemistry, 2012, Zajdel, Paweł et. al.
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists
score: 3.00308, European Journal of Medicinal Chemistry, 2012, Zajdel, Paweł et. al.
Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II
score: 2.9877639, Bioorganic & Medicinal Chemistry, 2005, Muthas, Daniel et. al.
Discovery and optimization of novel purines as potent and selective CB2 agonists
score: 2.9673067, Bioorganic & Medicinal Chemistry Letters, 2012, Hollinshead, Sean P. et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 2.9483732, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Discovery and optimization of novel purines as potent and selective CB2 agonists
score: 2.9479996, Bioorganic & Medicinal Chemistry Letters, 2012, Hollinshead, Sean P. et. al.
Novel selective and potent 5-HT reuptake inhibitors with 5-HT 1D antagonist activity: chemistry and pharmacological evaluation of a series of thienopyran derivatives
score: 2.9476218, Bioorganic & Medicinal Chemistry, 2004, Torrado, Alicia et. al.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 2.9414623, Bioorganic & Medicinal Chemistry Letters, 2012, Arasappan, Ashok et. al.
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors
score: 2.9329371, Bioorganic & Medicinal Chemistry, 2006, Moretto, A.F. et. al.
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
score: 2.9321754, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Hee Jin et. al.
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
score: 2.9321754, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Hee Jin et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 2.930314, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Inhibitors of Dengue Virus and West Nile Virus Proteases Based on the Aminobenzamide Scaffold
score: 2.9239603, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
score: 2.9136166, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Hee Jin et. al.
Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.
score: 2.9117437, Antimicrobial agents and chemotherapy, 2012, Kusano-Kitazume, Akiko et. al.
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors
score: 2.9093767, Bioorganic & Medicinal Chemistry, 2012, Wu, Peng et. al.
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors
score: 2.9093767, Bioorganic & Medicinal Chemistry, 2012, Wu, Peng et. al.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors
score: 2.9060786, Bioorganic & Medicinal Chemistry Letters, 2012, Peterson, Emily A. et. al.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors
score: 2.8901428, Bioorganic & Medicinal Chemistry Letters, 2012, Peterson, Emily A. et. al.
Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptase.
score: 2.8852602, Antimicrobial agents and chemotherapy, 1998, Sudbeck, E A et. al.
SAR Analysis of a Series of Acylthiourea Derivatives Possessing Broad-Spectrum Antiviral Activity
score: 2.881292, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors
score: 2.8533727, Bioorganic & Medicinal Chemistry, 2012, Wu, Peng et. al.
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.8524686, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability
score: 2.8499891, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Junwon et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.8491109, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.8491109, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
The design, synthesis and biological evaluation of PIM kinase inhibitors
score: 2.8483512, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
score: 2.8330449, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
score: 2.8330449, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
score: 2.8330449, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.
score: 2.8312454, Antimicrobial agents and chemotherapy, 2011, Vilchèze, Catherine et. al.
Design, synthesis and structure–activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors
score: 2.8261477, Bioorganic & Medicinal Chemistry Letters, 2012, Fernandez, Maria-Carmen et. al.
Design, synthesis and structure–activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors
score: 2.8261477, Bioorganic & Medicinal Chemistry Letters, 2012, Fernandez, Maria-Carmen et. al.
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
score: 2.8245864, Bioorganic & Medicinal Chemistry, 2012, Hayakawa, Ichiro et. al.
Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B)
score: 2.8181008, Bioorganic & Medicinal Chemistry, 2002, Liljebris, Charlotta et. al.
Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors
score: 2.8098575, Bioorganic & Medicinal Chemistry, 1998, Scheidt, Karl A. et. al.
Benzo[1,2- c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds
score: 2.8089834, Bioorganic & Medicinal Chemistry, 2005, Aguirre, Gabriela et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part III: Synthesis of potent antagonists with α vβ 3/α IIbβ 3 dual activity and improved water solubility
score: 2.808041, Bioorganic & Medicinal Chemistry, 2006, Ishikawa, Minoru et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.8062758, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors
score: 2.80531, Bioorganic & Medicinal Chemistry, 2012, Harada, Koichiro et. al.
Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors
score: 2.80531, Bioorganic & Medicinal Chemistry, 2012, Harada, Koichiro et. al.
Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors
score: 2.80531, Bioorganic & Medicinal Chemistry, 2012, Harada, Koichiro et. al.
Hybrid furoxanylN-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates
score: 2.8003255, European Journal of Medicinal Chemistry, 2013, Hernández, Paola et. al.
Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates
score: 2.8003255, European Journal of Medicinal Chemistry, 2013, Hernández, Paola et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.7955247, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
Structure-based Bioisosterism Design, Synthesis and Biological Evaluation of Novel 1,2,4-Triazin-6-ylthioacetamides As Potent HIV-1 NNRTIs
score: 2.7953864, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold
score: 2.7903948, Bioorganic & Medicinal Chemistry, 2006, Xie, Aihua; Sivaprakasam, Prasanna; Doerksen, Robert J.
Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.7841849, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.7841849, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.7841849, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
Dihydropyridine neuropeptide Y Y 1 receptor antagonists 2
score: 2.7816732, Bioorganic & Medicinal Chemistry, 2004, Poindexter, Graham S et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.7808622, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.7808622, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.7808622, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
score: 2.7655694, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
score: 2.7655694, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
score: 2.7655694, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Structure-activity relationships of cyclic enediynes related to dynemicin A—II. Synthesis and antitumor activity of 9- and 12-substituted enediynes equipped with aryl carbamate moieties
score: 2.762678, Bioorganic & Medicinal Chemistry, 1997, Unno, Ryoichi et. al.
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure
score: 2.7609547, Bioorganic & Medicinal Chemistry, 2005, Yamazaki, Kazuo et. al.
Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines
score: 2.7572371, Bioorganic & Medicinal Chemistry, 2012, Dosa, Stefan et. al.
Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines
score: 2.7572371, Bioorganic & Medicinal Chemistry, 2012, Dosa, Stefan et. al.
Recent methodologies toward the synthesis of valdecoxib: A potential 3,4-diarylisoxazolyl COX-II inhibitor
score: 2.7560746, European Journal of Medicinal Chemistry, 2010, Dadiboyena, Sureshbabu; Nefzi, Adel
3D-QSAR CoMFA/CoMSIA studies on Urokinase plasminogen activator (uPA) inhibitors: a strategic design in novel anticancer agents
score: 2.7542768, Bioorganic & Medicinal Chemistry, 2004, Bhongade, B.A.; Gadad, A.K.
Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors
score: 2.7536366, Bioorganic & Medicinal Chemistry, 2004, Singh, Sunil K. et. al.
An efficient one–pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.7498645, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.7449431, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Pharmacophore modeling, virtual screening and 3D-QSAR studies of 5-tetrahydroquinolinylidine aminoguanidine derivatives as sodium hydrogen exchanger inhibitors
score: 2.7441149, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Hardik G.; Patel, Paresh K.
Pharmacophore modeling, virtual screening and 3D-QSAR studies of 5-tetrahydroquinolinylidine aminoguanidine derivatives as sodium hydrogen exchanger inhibitors
score: 2.7441149, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Hardik G.; Patel, Paresh K.
A new structural theme in C 2-symmetric HIV-1 protease inhibitors: ortho-Substituted P1/P1′ side chains
score: 2.7432909, Bioorganic & Medicinal Chemistry, 2006, Wannberg, Johan et. al.
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
score: 2.7411716, Bioorganic & Medicinal Chemistry, 2012, Di Francesco, M. Emilia et. al.
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
score: 2.7411716, Bioorganic & Medicinal Chemistry, 2012, Di Francesco, M. Emilia et. al.
N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion.
score: 2.7406879, Antimicrobial agents and chemotherapy, 2004, Jiang, Shibo et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.7391412, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.7391412, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.7391412, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-HSV agent
score: 2.7367062, Bioorganic & Medicinal Chemistry Letters, 2012, Karampuri, Srinivas et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.733363, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening
score: 2.732586, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Weijun; Chen, Gang; Zhu, Weiliang; Zuo, Zhili
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors
score: 2.7319894, European Journal of Medicinal Chemistry, 2012, Golub, Andriy G. et. al.
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors
score: 2.7319894, European Journal of Medicinal Chemistry, 2012, Golub, Andriy G. et. al.
Computational studies of COX-2 inhibitors: 3D-QSAR and docking
score: 2.7282588, Bioorganic & Medicinal Chemistry, 2004, Kim, Hye-Jung et. al.
Novel Morpholinone-Based d-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex
score: 2.727966, Bioorganic & Medicinal Chemistry, 2002, Dahlgren, Anders et. al.
Early phase drug discovery: Cheminformatics and computational techniques in identifying lead series
score: 2.7239078, Bioorganic & Medicinal Chemistry, 2012, Duffy, Bryan C. et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 2.7202735, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 2.7202735, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity
score: 2.7193504, Bioorganic & Medicinal Chemistry, 2006, Wheelock, Craig E. et. al.
C 17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1 H-imidazoles as novel C 17,20-lyase inhibitors
score: 2.7087168, Bioorganic & Medicinal Chemistry, 2004, Matsunaga, Nobuyuki et. al.
Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity
score: 2.706489, Bioorganic & Medicinal Chemistry, 2003, Sørensen, Morten Dahl et. al.
A Highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.7056516, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein
score: 2.7011222, Bioorganic & Medicinal Chemistry, 2012, Li, Huan-qiu; Yang, Jing; Ma, Shuhua; Qiao, Chunhua
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein
score: 2.7011222, Bioorganic & Medicinal Chemistry, 2012, Li, Huan-qiu; Yang, Jing; Ma, Shuhua; Qiao, Chunhua
Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study
score: 2.6999497, Bioorganic & Medicinal Chemistry, 2002, Cho, Won-Jea et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.6978002, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors
score: 2.6968903, Bioorganic & Medicinal Chemistry Letters, 2012, Bussenius, Joerg et. al.
Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase
score: 2.6933257, Bioorganic & Medicinal Chemistry, 2005, Khabnadideh, Soghra et. al.
Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: A novel class of cyclooxygenase-2 inhibitors
score: 2.6919139, Bioorganic & Medicinal Chemistry, 2005, Chen, Qiao-Hong; Praveen Rao, P.N.; Knaus, Edward E.
CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues
score: 2.6909021, Bioorganic & Medicinal Chemistry, 2006, Salama, Ismail et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.69024, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.69024, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.69024, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.6881256, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells
score: 2.6879668, Bioorganic & Medicinal Chemistry Letters, 2013, Medda, Federico et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.6858892, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
Design and synthesis of ( Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and ( Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity
score: 2.684667, Bioorganic & Medicinal Chemistry, 2005, Uddin, Md. Jashim; Rao, P.N. Praveen; Knaus, Edward E.
Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization
score: 2.6833612, European Journal of Medicinal Chemistry, 2012, Yang, Ling-Ling et. al.
Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization
score: 2.6833612, European Journal of Medicinal Chemistry, 2012, Yang, Ling-Ling et. al.
Synthesis and structure–activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold
score: 2.674852, Bioorganic & Medicinal Chemistry Letters, 2012, Wurz, Ryan P. et. al.
Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity
score: 2.6726163, European Journal of Medicinal Chemistry, 2012, Rasolofonjatovo, Evelia et. al.
Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity
score: 2.6726163, European Journal of Medicinal Chemistry, 2012, Rasolofonjatovo, Evelia et. al.
3D QSAR studies of AChE inhibitors based on molecular docking scores and CoMFA
score: 2.6719675, Bioorganic & Medicinal Chemistry Letters, 2006, Akula, Nagaraju et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.6716282, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.6716282, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems Part IV. 2-Alkyl substituents containing cationic heteroaromatics linked via a C–C bond
score: 2.6700975, Bioorganic & Medicinal Chemistry, 2001, Azami, Hidenori et. al.
Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3- O-(3-Aryl-2-propenyl)leucomycin analogues
score: 2.6672464, Bioorganic & Medicinal Chemistry, 2008, Furuuchi, Takeshi et. al.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.6617138, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.6617138, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.6617138, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase
score: 2.6519762, Bioorganic & Medicinal Chemistry, 2005, Jackson, Sharon A. et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.6508174, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
score: 2.6504389, European Journal of Medicinal Chemistry, 2012, Zhu, Wufu et. al.
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
score: 2.6504389, European Journal of Medicinal Chemistry, 2012, Zhu, Wufu et. al.
A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.6471356, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.6471356, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells
score: 2.6299956, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Breland et. al.
Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.6224146, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.6205934, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
3D-QSAR, homology modeling, and molecular docking studies on spiropiperidines analogues as agonists of nociceptin/orphanin FQ receptor
score: 2.6173835, Bioorganic & Medicinal Chemistry Letters, 2010, Liu, Ming; He, Lin; Hu, Xiaopeng; Liu, Peiqing; Luo, Hai-Bin
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors
score: 2.61694, European Journal of Medicinal Chemistry, 2012, Golub, Andriy G. et. al.
Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR)
score: 2.6155676, Bioorganic & Medicinal Chemistry Letters, 2012, Zinglé, Catherine et. al.
Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR)
score: 2.6155676, Bioorganic & Medicinal Chemistry Letters, 2012, Zinglé, Catherine et. al.
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102
score: 2.6148777, Bioorganic & Medicinal Chemistry, 2012, Huynh, Tri H.V. et. al.
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102
score: 2.6148777, Bioorganic & Medicinal Chemistry, 2012, Huynh, Tri H.V. et. al.
Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors
score: 2.6147452, Bioorganic & Medicinal Chemistry, 2006, Li, Xingnan; Vince, Robert
Antitumor agents 294. Novel E-ring-modified camptothecin–4β-anilino-4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents
score: 2.6138171, Bioorganic & Medicinal Chemistry, 2012, Ye, Deyong et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.613779, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.613779, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.613779, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists
score: 2.6108193, Bioorganic & Medicinal Chemistry Letters, 2004, Newhouse, Bradley et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.6105959, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.6054665, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.6054665, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles
score: 2.6043932, Bioorganic & Medicinal Chemistry, 2004, Ranatunge, Ramani R. et. al.
Discovery of MEK/PI3K dual inhibitor via structure-based virtual screening
score: 2.6035831, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Hwangseo; Lee, Soyoung; Hong, Sungwoo
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells
score: 2.6009803, Bioorganic & Medicinal Chemistry Letters, 2012, Pierre, Fabrice et. al.
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells
score: 2.6009803, Bioorganic & Medicinal Chemistry Letters, 2012, Pierre, Fabrice et. al.
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach
score: 2.5986795, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach
score: 2.5986795, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach
score: 2.5986795, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
Design, synthesis, and biological activity of N 6-substituted-4′-thioadenosines at the human A 3 adenosine receptor
score: 2.5973048, Bioorganic & Medicinal Chemistry, 2006, Jeong, Lak Shin et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity
score: 2.5972125, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity
score: 2.5972125, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
Structure–activity studies of a series of dipyrazolo[3,4- b:3′,4′- d]pyridin-3-ones binding to the immune regulatory protein B7.1
score: 2.5934688, Bioorganic & Medicinal Chemistry, 2003, Green, Neal J. et. al.
Design, Synthesis and Pharmacological Characterization of Coumarin-Based Fluorescent Analogs of Excitatory Amino Acid Transporter Subtype 1 selective Inhibitors, UCPH-101 and UCPH-102
score: 2.5927752, Bioorganic & Medicinal Chemistry, 2012, Huynh, Tri H.V. et. al.
Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II
score: 2.5924991, Bioorganic & Medicinal Chemistry, 2003, Dahlgren, Anders et. al.
Design and synthesis of procollagen C-proteinase inhibitors
score: 2.5921306, Bioorganic & Medicinal Chemistry Letters, 2012, Turtle, Eric et. al.
Design and synthesis of procollagen C-proteinase inhibitors
score: 2.5921306, Bioorganic & Medicinal Chemistry Letters, 2012, Turtle, Eric et. al.
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy- d-xylulose 5-phosphate reductoisomerase
score: 2.5914473, Bioorganic & Medicinal Chemistry, 2006, Woo, Youn-Hi; Fernandes, Roberta P.M.; Proteau, Philip J.
Design and synthesis of Rho kinase inhibitors (I)
score: 2.5907077, Bioorganic & Medicinal Chemistry, 2004, Takami, Atsuya et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one Derivatives as a Novel Class of Farnesoid X Receptor (FXR) Agonists
score: 2.5903221, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors
score: 2.5807084, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors
score: 2.5807084, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors
score: 2.5807084, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Virtual screening of combinatorial libraries across a gene family: in search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase.
score: 2.5780891, Antimicrobial agents and chemotherapy, 2001, Aronov, A M; Munagala, N R; Kuntz, I D; Wang, C C
Design, synthesis, and biological evaluation of ( E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases
score: 2.576323, Bioorganic & Medicinal Chemistry, 2006, Moreau, Anne et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.5746901, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: Improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy
score: 2.5745183, Bioorganic & Medicinal Chemistry, 2012, Kawakita, Youichi et. al.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families
score: 2.5737238, Bioorganic & Medicinal Chemistry Letters, 2012, Curtin, Michael L. et. al.
A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site
score: 2.5685361, Bioorganic & Medicinal Chemistry, 2004, Foloppe, Nicolas et. al.
Design, synthesis and biological activity of YM-60828 derivatives: potent and orally-Bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates
score: 2.5679825, Bioorganic & Medicinal Chemistry, 2002, Hirayama, Fukushi et. al.
Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3 H-diazirin-3-yl functional group for photo-affinity labeling
score: 2.5675692, Bioorganic & Medicinal Chemistry, 2009, Kumar, Nag S.; Young, Robert N.
Novel ligands for the human histamine H 1 receptor: Synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes
score: 2.5635206, Bioorganic & Medicinal Chemistry, 2006, Ghoneim, Ola M. et. al.
Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity
score: 2.5629201, European Journal of Medicinal Chemistry, 2012, Rasolofonjatovo, Evelia et. al.
Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: Hydroxybenzoyl-3,4-dihydroquinoxalin-2(1 H)-ones
score: 2.5611377, Bioorganic & Medicinal Chemistry, 2006, Mahaney, Paige E. et. al.
Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors
score: 2.5581487, Bioorganic & Medicinal Chemistry Letters, 2013, Kim, Junwon et. al.
Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
score: 2.5515433, Bioorganic & Medicinal Chemistry, 2006, Walker, Daniel P. et. al.
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques
score: 2.5490979, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yao et. al.
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques
score: 2.5490979, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yao et. al.
Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors
score: 2.5485989, Bioorganic & Medicinal Chemistry, 2012, Smith, Aaron L. et. al.
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2
score: 2.5478906, Bioorganic & Medicinal Chemistry Letters, 2012, Vaidya, Aditya Sudheer et. al.
Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH
score: 2.5475893, European Journal of Medicinal Chemistry, 2012, Larghi, Enrique L. et. al.
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3 H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family
score: 2.546707, Bioorganic & Medicinal Chemistry, 2005, Mai, Antonello et. al.
Early phase drug discovery: Cheminformatics and computational techniques in identifying lead series
score: 2.5464498, Bioorganic & Medicinal Chemistry, 2012, Duffy, Bryan C. et. al.
Early phase drug discovery: Cheminformatics and computational techniques in identifying lead series
score: 2.5464498, Bioorganic & Medicinal Chemistry, 2012, Duffy, Bryan C. et. al.
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
score: 2.5454233, Bioorganic & Medicinal Chemistry Letters, 2012, Dakin, Les A. et. al.
Development of ‘DFG-out’ inhibitors of gatekeeper mutant kinases
score: 2.5446835, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Hwan Geun et. al.
Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus
score: 2.5425614, Bioorganic & Medicinal Chemistry Letters, 2012, Lizarzaburu, Mike et. al.
Ligand-based designing, in silico screening, and biological evaluation of new potent fructose-1,6-bisphosphatase (FBPase) inhibitors
score: 2.5404106, European Journal of Medicinal Chemistry, 2012, Tayyem, Rabab F. et. al.
Ligand-based designing, in silico screening, and biological evaluation of new potent fructose-1,6-bisphosphatase (FBPase) inhibitors
score: 2.5404106, European Journal of Medicinal Chemistry, 2012, Tayyem, Rabab F. et. al.
New orally active PDE4 inhibitors with therapeutic potential
score: 2.5387424, Bioorganic & Medicinal Chemistry, 2004, Ochiai, Hiroshi et. al.
Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3- a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase
score: 2.5384746, Bioorganic & Medicinal Chemistry, 2006, Sun, Chuanwen; Zhang, Xiaodong; Huang, Hai; Zhou, Pei
Design, synthesis and bioactivities of novel diarylthiophenes: inhibitors of tumor necrosis factor-α (TNF-α) production
score: 2.5368103, Bioorganic & Medicinal Chemistry, 2002, Fujita, Masakazu; Hirayama, Tetsuya; Ikeda, Naoko
POMA analyses as new efficient bioinformatics’ platform to predict and optimize bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5360688, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
score: 2.5353895, European Journal of Medicinal Chemistry, 2012, Zhu, Wufu et. al.
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
score: 2.5349706, European Journal of Medicinal Chemistry, 2012, Xie, Hui et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
score: 2.5347927, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates
score: 2.5335449, Bioorganic & Medicinal Chemistry Letters, 2012, Sund, Christian et. al.
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates
score: 2.5335449, Bioorganic & Medicinal Chemistry Letters, 2012, Sund, Christian et. al.
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
score: 2.5276291, Bioorganic & Medicinal Chemistry, 2006, Collins, Ian et. al.
Discovery and optimization of a series of liver X receptor antagonists
score: 2.5273336, Bioorganic & Medicinal Chemistry Letters, 2012, Jiao, XianYun et. al.
Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2′ to P1/P1′
score: 2.5261389, Bioorganic & Medicinal Chemistry, 2005, Ax, Anna et. al.
Design, synthesis, and biological evaluation of 1,3-diarylprop-2-en-1-ones : A novel class of cyclooxygenase-2 inhibitors
score: 2.525668, Bioorganic & Medicinal Chemistry, 2006, Zarghi, Afshin et. al.
An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.524857, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.524857, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.524857, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
score: 2.5247342, Bioorganic & Medicinal Chemistry Letters, 2012, Dakin, Les A. et. al.
Solid-phase synthesis and bioevaluation of Lupeol-based libraries as antimalarial agents
score: 2.5227983, Bioorganic & Medicinal Chemistry Letters, 2002, Srinivasan, T et. al.
‘Sum of activities’ as dependent parameter: A new CoMFA-based approach for the design of pan PPAR agonists
score: 2.5219355, European Journal of Medicinal Chemistry, 2009, Sundriyal, Sandeep; Bharatam, Prasad V.
Analogues of FAUC 73 revealing new insights into the structural requirements of nonaromatic dopamine D3 receptor agonists
score: 2.5211103, Bioorganic & Medicinal Chemistry, 2004, Lenz, Carola et. al.
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase
score: 2.519841, Bioorganic & Medicinal Chemistry Letters, 2012, Ding, Min et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2
score: 2.5183328, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Semisynthetic neoclerodanes as kappa opioid receptor probes
score: 2.5179122, Bioorganic & Medicinal Chemistry, 2012, Lovell, Kimberly M. et. al.
Semisynthetic neoclerodanes as kappa opioid receptor probes
score: 2.5179122, Bioorganic & Medicinal Chemistry, 2012, Lovell, Kimberly M. et. al.
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)
score: 2.5175931, Bioorganic & Medicinal Chemistry, 2012, Banoglu, Erden et. al.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
score: 2.5164123, Bioorganic & Medicinal Chemistry, 2012, Tashiro, Takuya et. al.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
score: 2.5164123, Bioorganic & Medicinal Chemistry, 2012, Tashiro, Takuya et. al.
D-Ring Modified Estrone Derivatives as Novel Potent Inhibitors of Steroid Sulfatase
score: 2.5161801, Bioorganic & Medicinal Chemistry, 2003, Fischer, Delphine S et. al.
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.5140279, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.5140279, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5118032, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5118032, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5118032, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
Pharmacophore Modeling, Virtual Screening and 3D-QSAR Studies of 5-tetrahydroquinolinylidine Aminoguanidine Derivatives as Sodium Hydrogen Exchanger Inhibitors
score: 2.5113585, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Hardik G.; Patel, Paresh K.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.5113136, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors
score: 2.5098839, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Moon H. et. al.
Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
score: 2.5096541, Bioorganic & Medicinal Chemistry, 2012, Romagnoli, Romeo et. al.
Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
score: 2.5096541, Bioorganic & Medicinal Chemistry, 2012, Romagnoli, Romeo et. al.
Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
score: 2.5096541, Bioorganic & Medicinal Chemistry, 2012, Romagnoli, Romeo et. al.
Synthesis and biological evaluation of 1,3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 inhibitors
score: 2.5085226, Bioorganic & Medicinal Chemistry, 2006, Zarghi, Afshin et. al.
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 2.507184, Bioorganic & Medicinal Chemistry Letters, 2012, Bennett, Frank et. al.
Structure-Based Design of Rhodanine-based Acylsulfonamide Derivatives as Antagonists of the Anti-apoptotic Bcl-2 Protein
score: 2.5066672, Bioorganic & Medicinal Chemistry, 2012, Li, Huan-qiu; Yang, Jing; Ma, Shuhua; Qiao, Chunhua
2-Aminothiophenes as Building Blocks in Heterocyclic Synthesis: Synthesis and Antimicrobial Evaluation of a New Class of Pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and Pyridin-2-one Derivatives
score: 2.5060901, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
score: 2.5042357, Bioorganic & Medicinal Chemistry, 2012, Tashiro, Takuya et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part II
score: 2.503953, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Design and synthesis of procollagen C-proteinase inhibitors
score: 2.503642, Bioorganic & Medicinal Chemistry Letters, 2012, Turtle, Eric et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2
score: 2.5030143, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2
score: 2.5030143, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.501603, European Journal of Medicinal Chemistry, 2012, Vega, María Celeste et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.501603, European Journal of Medicinal Chemistry, 2012, Vega, Maria Celeste et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.501603, European Journal of Medicinal Chemistry, 2012, Vega, María Celeste et. al.
A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus 1
score: 2.4982832, Bioorganic & Medicinal Chemistry, 2006, Arhin, Francis et. al.
The design, synthesis, and biological evaluation of PIM kinase inhibitors
score: 2.4977048, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
The design, synthesis, and biological evaluation of PIM kinase inhibitors
score: 2.4977048, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
The design, synthesis and biological evaluation of PIM kinase inhibitors
score: 2.4977048, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents
score: 2.4959195, Bioorganic & Medicinal Chemistry, 2006, Shinozuka, Tsuyoshi et. al.
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation
score: 2.4951368, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation
score: 2.4951368, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.4951335, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
score: 2.4930566, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D 3 analogues containing amide bond
score: 2.4913372, Bioorganic & Medicinal Chemistry Letters, 2002, Suhara, Yoshitomo et. al.
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors
score: 2.4897621, European Journal of Medicinal Chemistry, 2012, Jadhav, Ravindra D. et. al.
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors
score: 2.4897621, European Journal of Medicinal Chemistry, 2012, Jadhav, Ravindra D. et. al.
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors
score: 2.4897621, European Journal of Medicinal Chemistry, 2012, Jadhav, Ravindra D. et. al.
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.4890129, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
score: 2.4879479, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
score: 2.4855366, Bioorganic & Medicinal Chemistry Letters, 2012, Hsu, John T.-A. et. al.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
score: 2.4855366, Bioorganic & Medicinal Chemistry Letters, 2012, Hsu, John T.-A. et. al.
Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.
score: 2.485309, Antimicrobial agents and chemotherapy, 2011, Zoraghi, Roya et. al.
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
score: 2.4836411, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
score: 2.4836411, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
score: 2.4836411, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Structure–activity relationships of tyrosinase inhibitory combinatorial library of 2,5-disubstituted-1,3,4-oxadiazole analogues
score: 2.4822302, Bioorganic & Medicinal Chemistry, 2005, Khan, Mahmud Tareq Hassan et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.4821665, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Acyclic amides as estrogen receptor ligands: Synthesis, binding, activity and receptor interaction
score: 2.4820865, Bioorganic & Medicinal Chemistry, 2000, Stauffer, Shaun R et. al.
Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.4812446, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.4812446, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.4812446, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.4810918, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.4810918, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.4810918, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening
score: 2.478164, Bioorganic & Medicinal Chemistry Letters, 2012, Moser, Daniel et. al.
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening
score: 2.478164, Bioorganic & Medicinal Chemistry Letters, 2012, Moser, Daniel et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.4767401, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
Investigation on QSAR and binding mode of a new class of human rhinovirus-14 inhibitors by CoMFA and docking experiments
score: 2.4716941, Bioorganic & Medicinal Chemistry, 1996, Artico, Marino et. al.
Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation
score: 2.4699733, Bioorganic & Medicinal Chemistry Letters, 2012, Ellard, Katie et. al.
Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones
score: 2.4692332, Bioorganic & Medicinal Chemistry, 2003, Kongkathip, Ngampong et. al.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families
score: 2.467853, Bioorganic & Medicinal Chemistry Letters, 2012, Curtin, Michael L. et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as Potent Antagonists Targeting Exchange Proteins Directly Activated by cAMP
score: 2.4672748, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position
score: 2.4661794, Bioorganic & Medicinal Chemistry, 2006, Yoshida, Ken-ichi et. al.
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
score: 2.4628064, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Discovery and Optimization of Benzenesulfonanilide Derivatives as a Novel Class of 11β-HSD1 Inhibitors
score: 2.462096, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Carbapenem-based prodrugs. Design, synthesis, and biological evaluation of carbapenems
score: 2.4616669, European Journal of Medicinal Chemistry, 2005, Hakimelahi, Gholam Hossein et. al.
Synthesis and antiparasitic activity of albendazole and mebendazole analogues
score: 2.4612353, Bioorganic & Medicinal Chemistry, 2003, Navarrete-Vázquez, Gabriel et. al.
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
score: 2.4607512, Bioorganic & Medicinal Chemistry, 2006, Ersmark, Karolina et. al.
QSAR study for a novel series of ortho monosubstituted phenoxy analogues of α 1-adrenoceptor antagonist WB4101
score: 2.4600816, Bioorganic & Medicinal Chemistry, 2005, Fumagalli, Laura et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
score: 2.4582641, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
The discovery of glycine and related amino acid-based factor Xa inhibitors
score: 2.4575995, Bioorganic & Medicinal Chemistry, 2006, Kohrt, Jeffrey T. et. al.
Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents
score: 2.457089, Bioorganic & Medicinal Chemistry, 2005, Johns, Brian A. et. al.
Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV
score: 2.4567977, Bioorganic & Medicinal Chemistry, 2006, Flosi, William J. et. al.
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer
score: 2.4566787, Bioorganic & Medicinal Chemistry, 2012, Zhu, Gui-Dong et. al.
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
score: 2.4555964, Bioorganic & Medicinal Chemistry, 2004, Carrico, Dora et. al.
Synthesis and biological activity of novel thyroid hormone analogues: 5′-aryl substituted GC-1 derivatives
score: 2.4542586, Bioorganic & Medicinal Chemistry, 2002, Chiellini, Grazia et. al.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
score: 2.4537939, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
score: 2.4537939, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Comparative molecular field analysis and comparative molecular similarity indices analysis of boron-containing human thymidine kinase 1 substrates
score: 2.4534211, Bioorganic & Medicinal Chemistry, 2006, Bandyopadhyaya, Achintya K.; Tiwari, Rohit; Tjarks, Werner
A credit-card library approach for disrupting protein–protein interactions
score: 2.4530334, Bioorganic & Medicinal Chemistry, 2006, Xu, Yang et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.4516836, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Molecular modeling, design, synthesis, and biological evaluation of novel 3′,4′-dicamphanoyl-(+)- cis-khellactone (DCK) analogs as potent anti-HIV agents
score: 2.4510224, Bioorganic & Medicinal Chemistry, 2005, Xie, Lan et. al.
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents
score: 2.4489976, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xiao-Feng et. al.
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice
score: 2.4487344, Bioorganic & Medicinal Chemistry, 2012, dos Santos Filho, José Maurício et. al.
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice
score: 2.4487344, Bioorganic & Medicinal Chemistry, 2012, dos Santos Filho, José Maurício et. al.
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses
score: 2.4482163, Bioorganic & Medicinal Chemistry, 2005, Gudmundsson, Kristjan S. et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.4457771, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.4457771, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Optimization and Structure-Activity Relationships of a Series of Potent Inhibitors of Methicillin-Resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as Novel Antimicrobial Agents
score: 2.4456525, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
Inhibitors of acyl-CoA: cholesterol O-acyltransferase (ACAT). Part 1: Identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N′-arylureas
score: 2.4447364, Bioorganic & Medicinal Chemistry, 1998, Tanaka, Akira et. al.
The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors
score: 2.4444189, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Moon H. et. al.
Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy
score: 2.4443807, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Hyeseung et. al.
Novel synthetic analogs of the Pseudomonas autoinducer
score: 2.4428182, Bioorganic & Medicinal Chemistry Letters, 1999, Kline, T. et. al.
The synthesis and antibacterial activity of totarol derivatives. part 1: modifications of ring-C and pro-drugs
score: 2.4423164, Bioorganic & Medicinal Chemistry, 1999, Evans, Gary B et. al.
Design and synthesis of new (E)-Cinnamic N-Acylhydrazones as potent Antitrypanosomal agents
score: 2.4420112, European Journal of Medicinal Chemistry, 2012, Carvalho, Samir A. et. al.
Hit to Lead Optimization of a Novel Class of Squarate-containing Polo-like Kinases Inhibitors
score: 2.4405531, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2/4-quinolinecarbaldehyde derivatives
score: 2.4404866, Bioorganic & Medicinal Chemistry, 2006, Nayyar, Amit et. al.
Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes
score: 2.4382608, Bioorganic & Medicinal Chemistry Letters, 2012, DeNinno, Michael P. et. al.
Novel berberine triazoles: Synthesis, antimicrobial evaluation and competitive interactions with metal ions to Human Serum Albumin
score: 2.4377919, Bioorganic & Medicinal Chemistry Letters, 2013, Zhang, Shao-Lin et. al.
New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design
score: 2.4373161, Bioorganic & Medicinal Chemistry, 2006, Olsen, Lars et. al.
Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems. Part III:
score: 2.4361418, Bioorganic & Medicinal Chemistry, 1999, Azami, Hidenori et. al.
Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
score: 2.4348134, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
score: 2.4348134, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.
score: 2.4328349, Antimicrobial agents and chemotherapy, 2006, Yang, Youjun et. al.
Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists
score: 2.4307131, Bioorganic & Medicinal Chemistry, 2012, Takeda, Kunitoshi et. al.
Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists
score: 2.4307131, Bioorganic & Medicinal Chemistry, 2012, Takeda, Kunitoshi et. al.
Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists
score: 2.4307131, Bioorganic & Medicinal Chemistry, 2012, Takeda, Kunitoshi et. al.
Combinatorial design of nonsymmetrical cyclic urea inhibitors of aspartic protease of HIV-1
score: 2.4292688, Bioorganic & Medicinal Chemistry, 2005, Frecer, Vladimír; Burello, Enrico; Miertus, Stanislav
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors
score: 2.4290229, Bioorganic & Medicinal Chemistry Letters, 2012, Girijavallabhan, Vinay M. et. al.
Synthesis and in vitro antitumor activity of novel scopoletin derivatives
score: 2.4281182, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Wukun et. al.
Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor
score: 2.4276094, Bioorganic & Medicinal Chemistry, 2005, Kuramochi, Takahiro et. al.
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents
score: 2.4268343, Bioorganic & Medicinal Chemistry, 2006, Monk, Keith A. et. al.
A road less traveled by: Exploring a decade of Ellman chemistry
score: 2.4264726, Bioorganic & Medicinal Chemistry, 2009, Shelat, Anang A.; Guy, R. Kiplin
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.4237886, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.4237886, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
score: 2.4236672, European Journal of Medicinal Chemistry, 2012, Xie, Hui et. al.
Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity
score: 2.423349, Bioorganic & Medicinal Chemistry, 2013, Taygerly, Joshua P. et. al.
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents
score: 2.4227221, European Journal of Medicinal Chemistry, 2012, Carvalho, Samir A. et. al.
Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors
score: 2.4227108, Bioorganic & Medicinal Chemistry Letters, 2012, Miller, Michael M. et. al.
Design, synthesis and biological activity of acyl substituted 3-amino-5-methyl-1,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones as potential hypnotic drugs
score: 2.4219023, European Journal of Medicinal Chemistry, 2005, Falcó, José L. et. al.
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
score: 2.4216371, Bioorganic & Medicinal Chemistry Letters, 2012, Tell, Volkmar et. al.
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
score: 2.4216371, Bioorganic & Medicinal Chemistry Letters, 2012, Tell, Volkmar et. al.
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
score: 2.4216371, Bioorganic & Medicinal Chemistry Letters, 2012, Tell, Volkmar et. al.
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
score: 2.4199212, European Journal of Medicinal Chemistry, 2012, Xie, Hui et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.419727, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.4184321, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
Quantitative structure–activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents
score: 2.4182986, Bioorganic & Medicinal Chemistry Letters, 2008, Chen, Ke-xian; Xie, Hai-ying; Li, Zu-guang; Gao, Jian-rong
Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum
score: 2.4156656, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Nitro and amino substitution within the A-ring of 5 H-8,9-dimethoxy-5-(2- N, N-dimethylaminoethyl)dibenzo[ c, h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity
score: 2.4144669, Bioorganic & Medicinal Chemistry, 2004, Ruchelman, Alexander L et. al.
3D-QSAR CoMFA, CoMSIA studies on substituted ureas as Raf-1 kinase inhibitors and its confirmation with structure-based studies
score: 2.412264, Bioorganic & Medicinal Chemistry, 2004, Thaimattam, Ram et. al.
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques
score: 2.4111963, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yao et. al.
Highly potent aminopyridines as Syk kinase inhibitors
score: 2.4103797, Bioorganic & Medicinal Chemistry Letters, 2012, Castillo, Marcos et. al.
Imidazo[1,2- b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors
score: 2.4098122, Bioorganic & Medicinal Chemistry Letters, 2004, Byth, Kate F et. al.
Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3
score: 2.4097846, Bioorganic & Medicinal Chemistry, 2006, Rönn, Robert et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.4081653, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Arylazolyl(azinyl)thioacetanilides. Part 10: Design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors
score: 2.4075472, Bioorganic & Medicinal Chemistry, 2012, Li, Xiao et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
score: 2.4074739, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
score: 2.4074739, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
score: 2.4074739, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
score: 2.4066243, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yingyi et. al.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
score: 2.4066243, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yingyi et. al.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
score: 2.4066243, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yingyi et. al.
Design, synthesis, and structure–activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF1 receptor antagonists
score: 2.4060944, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors
score: 2.4057954, Bioorganic & Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening
score: 2.4042685, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Hwangseo; Chien, Pham Ngoc; Ryu, Seong Eon
Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
score: 2.4036191, Antimicrobial agents and chemotherapy, 2001, Clements, J M et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.4028928, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.4028928, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Inhibitors of lipoprotein(a) assembly
score: 2.4017377, Bioorganic & Medicinal Chemistry, 2003, Sexton, Karen E et. al.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.4006976, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
score: 2.4000524, Bioorganic & Medicinal Chemistry Letters, 2012, Karle, Michael; Knecht, Wolfgang; Xue, Yafeng
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
score: 2.4000524, Bioorganic & Medicinal Chemistry Letters, 2012, Karle, Michael; Knecht, Wolfgang; Xue, Yafeng
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.3989784, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
score: 2.3980968, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
score: 2.3980968, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Development of anti-coxsackievirus agents targeting 3C protease
score: 2.3964012, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Bo-Kyoung et. al.
Development of anti-coxsackievirus agents targeting 3C protease
score: 2.3964012, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Bo-Kyoung et. al.
Development of anti-coxsackievirus agents targeting 3C protease
score: 2.3964012, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Bo-Kyoung et. al.
Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051
score: 2.3960152, Bioorganic & Medicinal Chemistry Letters, 2009, Enache, Livia A. et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.3959162, European Journal of Medicinal Chemistry, 2012, Vega, Maria Celeste et. al.
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies
score: 2.3941567, Bioorganic & Medicinal Chemistry Letters, 2012, Arán, Vicente J.; Kaiser, Marcel; Dardonville, Christophe
Potent and selective thrombin inhibitors featuring hydrophobic, basic P 3P 4-aminoalkyllactam moieties
score: 2.3924545, Bioorganic & Medicinal Chemistry Letters, 1998, Semple, J.Edward et. al.
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase
score: 2.3916994, Bioorganic & Medicinal Chemistry, 2005, Levell, Julian et. al.
Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
score: 2.3914352, Bioorganic & Medicinal Chemistry Letters, 2012, Aiguadé, Josep et. al.
Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
score: 2.3914352, Bioorganic & Medicinal Chemistry Letters, 2012, Aiguadé, Josep et. al.
Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
score: 2.3914352, Bioorganic & Medicinal Chemistry Letters, 2012, Aiguadé, Josep et. al.
Characteristics of known drug space. Natural products, their derivatives and synthetic drugs
score: 2.3908575, European Journal of Medicinal Chemistry, 2010, Bade, Richard; Chan, Ho-Fung; Reynisson, Jóhannes
A σ1 receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ols (AHDs)
score: 2.3897253, Bioorganic & Medicinal Chemistry Letters, 2012, Banister, Samuel D. et. al.
Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
score: 2.3891052, Bioorganic & Medicinal Chemistry, 2012, Davies, Nicholas G.M. et. al.
Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
score: 2.3891052, Bioorganic & Medicinal Chemistry, 2012, Davies, Nicholas G.M. et. al.
A novel class of sodium/calcium exchanger inhibitor: design, synthesis, and structure–activity relationships of 3,4-dihydro-2(1 H)-quinazolinone derivatives
score: 2.3886582, Bioorganic & Medicinal Chemistry, 2005, Hasegawa, Hirohiko et. al.
Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance
score: 2.3885521, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance
score: 2.3885521, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Synthesis and docking studies of novel antitumor benzimidazoles
score: 2.384636, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Synthesis and docking studies of novel antitumor benzimidazoles
score: 2.384636, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Synthesis and docking studies of novel antitumor benzimidazoles
score: 2.384636, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid
score: 2.3846004, Bioorganic & Medicinal Chemistry, 2004, El-Araby, Moustafa E et. al.
3D QSAR studies on T-type calcium channel blockers using CoMFA and CoMSIA
score: 2.3838214, Bioorganic & Medicinal Chemistry, 2004, Doddareddy, Munikumar Reddy et. al.
Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1
score: 2.3837959, Bioorganic & Medicinal Chemistry Letters, 2012, Le Brazidec, Jean-Yves et. al.
Two- and three-dimensional quantitative structure–activity relationships for a series of purine nucleoside phosphorylase inhibitors
score: 2.3836733, Bioorganic & Medicinal Chemistry, 2006, Castilho, Marcelo S. et. al.
Contribution of indazolinone tautomers to kinase activity
score: 2.382927, Bioorganic & Medicinal Chemistry Letters, 2012, Vasudevan, Anil et. al.
Contribution of indazolinone tautomers to kinase activity
score: 2.382927, Bioorganic & Medicinal Chemistry Letters, 2012, Vasudevan, Anil et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.381945, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Inhibitors of HIV-1 attachment. Part 11: The discovery and structure–activity relationships associated with 4,6-diazaindole cores
score: 2.3810729, Bioorganic & Medicinal Chemistry Letters, 2013, Bender, John A. et. al.
Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides
score: 2.3807651, Bioorganic & Medicinal Chemistry Letters, 2010, Ali, Abdelselam et. al.
Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation
score: 2.3787954, Bioorganic & Medicinal Chemistry Letters, 2012, Ellard, Katie et. al.
Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation
score: 2.3787954, Bioorganic & Medicinal Chemistry Letters, 2012, Ellard, Katie et. al.
Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower log D limits based on permeability
score: 2.3774229, Bioorganic & Medicinal Chemistry Letters, 2009, Waring, Michael J.
Combining pharmacophore, docking and substructure search approaches to identify and optimize novel B-RafV600E inhibitors
score: 2.3774138, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Zhijian et. al.
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailablemPGES-1 inhibitor for the potential treatment of inflammation
score: 2.3771681, Bioorganic & Medicinal Chemistry Letters, 2013, Arhancet, Graciela B. et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.376364, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase
score: 2.3763355, Bioorganic & Medicinal Chemistry, 2003, Mano, Takashi et. al.
Structure–activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives
score: 2.3758638, Bioorganic & Medicinal Chemistry Letters, 2012, Ikeda, Reiko et. al.
Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency
score: 2.3757491, Bioorganic & Medicinal Chemistry Letters, 2013, Bollini, Mariela et. al.
Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors
score: 2.3756723, Bioorganic & Medicinal Chemistry, 2006, Shinji, Chihiro et. al.
Design and synthesis of acyclic triaryl ( Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors
score: 2.3732083, Bioorganic & Medicinal Chemistry, 2004, Uddin, Md. Jashim; Rao, P.N. Praveen; Knaus, Edward E.
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives
score: 2.373044, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives
score: 2.373044, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives
score: 2.373044, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: Identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid
score: 2.3715975, Bioorganic & Medicinal Chemistry Letters, 2013, Lee, Kijae et. al.
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors
score: 2.3714893, Bioorganic & Medicinal Chemistry, 2012, Ohashi, Tomohiro et. al.
Synthesis of 1,1-difluoro-5-(1 H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase
score: 2.3713539, Bioorganic & Medicinal Chemistry, 1998, Yokomatsu, Tsutomu et. al.
Computational design of novel fullerene analogues as potential HIV-1 PR inhibitors: Analysis of the binding interactions between fullerene inhibitors and HIV-1 PR residues using 3D QSAR, molecular docking and molecular dynamics simulations
score: 2.3709515, Bioorganic & Medicinal Chemistry, 2008, Durdagi, Serdar et. al.
Construction of a virtual combinatorial library using SMILES strings to discover potential structure-diverse PPAR modulators
score: 2.3682812, European Journal of Medicinal Chemistry, 2005, Liao, Chenzhong et. al.
New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 2: Synthesis and structure–activity relationships in the S-3578 series
score: 2.3672112, Bioorganic & Medicinal Chemistry, 2004, Yoshizawa, Hidenori et. al.
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines
score: 2.3655796, Bioorganic & Medicinal Chemistry Letters, 2012, Lombardo, Caterina M. et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.3655571, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.3655571, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.3655571, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
1,3-Azoles from ortho-naphthoquinones: Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis
score: 2.3642119, Bioorganic & Medicinal Chemistry, 2012, Moura, Kelly C.G. et. al.
1,3-Azoles from ortho-naphthoquinones: Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis
score: 2.3642119, Bioorganic & Medicinal Chemistry, 2012, Moura, Kelly C.G. et. al.
9- cis-Retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists
score: 2.3633705, Bioorganic & Medicinal Chemistry Letters, 2004, Alvarez, Rosana et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3633575, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3633575, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3633575, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors
score: 2.3624538, Bioorganic & Medicinal Chemistry Letters, 2013, Jin, Meizhong et. al.
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors
score: 2.3624538, Bioorganic & Medicinal Chemistry Letters, 2013, Jin, Meizhong et. al.
3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors
score: 2.3616176, European Journal of Medicinal Chemistry, 2006, Singh, S.K.; Dessalew, N.; Bharatam, P.V.
Dimerization of β-tryptase inhibitors, does it work for both basic and neutral P1 groups?
score: 2.3612727, Bioorganic & Medicinal Chemistry Letters, 2012, Liang, Guyan et. al.
Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
score: 2.3604351, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Xiao-Guang et. al.
Design, synthesis and anticancer activity of 1-acyl-3-amino- 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
score: 2.3604351, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Xiao-Guang et. al.
Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
score: 2.3604351, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Xiao-Guang et. al.
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase
score: 2.3601746, Bioorganic & Medicinal Chemistry, 1997, Gallagher, Timothy F. et. al.
The Discovery of YM-60828: A Potent, Selective and Orally-Bioavailable Factor Xa Inhibitor
score: 2.3596056, Bioorganic & Medicinal Chemistry, 2002, Hirayama, Fukushi et. al.
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies
score: 2.3547252, Bioorganic & Medicinal Chemistry Letters, 2012, Arán, Vicente J.; Kaiser, Marcel; Dardonville, Christophe
3D-QSAR and molecular docking study on bisarylmaleimide series as glycogen synthase kinase 3, cyclin dependent kinase 2 and cyclin dependent kinase 4 inhibitors: An insight into the criteria for selectivity
score: 2.3540018, European Journal of Medicinal Chemistry, 2007, Dessalew, Nigus; Bharatam, Prasad V.
Contribution of Indazolinone Tautomers to Kinase Activity
score: 2.3530493, Bioorganic & Medicinal Chemistry Letters, 2012, Vasudevan, Anil et. al.
A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: Design, synthesis and molecular modeling study
score: 2.3506185, European Journal of Medicinal Chemistry, 2012, Huang, Dawei; Li, Xiaohui; Wei, Yingdong; Xiu, Zhilong
Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents
score: 2.3495253, Bioorganic & Medicinal Chemistry Letters, 2013, Kamal, Ahmed et. al.
Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity
score: 2.34903, Bioorganic & Medicinal Chemistry, 2000, Suich, Daniel J et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.3475755, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.3475755, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.3475755, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives
score: 2.347437, Bioorganic & Medicinal Chemistry, 1998, Cho, Won-Jea et. al.
Discovery of Nitroheterocycles Active against African Trypanosomes. In Vitro Screening and Preliminary SAR Studies
score: 2.3473018, Bioorganic & Medicinal Chemistry Letters, 2012, Arán, Vicente J.; Kaiser, Marcel; Dardonville, Christophe
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
score: 2.3467509, Bioorganic & Medicinal Chemistry Letters, 2012, Chapman, Timothy M. et. al.
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
score: 2.3467509, Bioorganic & Medicinal Chemistry Letters, 2012, Chapman, Timothy M. et. al.
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor
score: 2.3463499, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, Jared N. et. al.
Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors
score: 2.3458221, Bioorganic & Medicinal Chemistry Letters, 2012, Matsufuji, Tetsuyoshi et. al.
The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors
score: 2.3454637, Bioorganic & Medicinal Chemistry Letters, 2013, Tang, Jun; Lackey, Karen E.; Dickerson, Scott H.
New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase
score: 2.3454407, Bioorganic & Medicinal Chemistry, 1997, Bonnet, Béatrice et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3452328, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs
score: 2.3441549, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Cuihua et. al.
Synthesis and antibacterial activity of new N-linked 5-triazolylmethyl oxazolidinones
score: 2.3432836, Bioorganic & Medicinal Chemistry, 2005, Phillips, Oludotun A. et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3421099, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3421099, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy
score: 2.339634, Bioorganic & Medicinal Chemistry Letters, 2012, Zhou, Ting et. al.
Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding
score: 2.3396016, European Journal of Medicinal Chemistry, 2012, Uttekar, Mayur M. et. al.
Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding
score: 2.3396016, European Journal of Medicinal Chemistry, 2012, Uttekar, Mayur M. et. al.
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety
score: 2.3390137, Bioorganic & Medicinal Chemistry, 2013, Konno, Sho et. al.
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
score: 2.3388815, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities
score: 2.338586, Bioorganic & Medicinal Chemistry, 2004, Kurimoto, Ayumu et. al.
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators
score: 2.33778, European Journal of Medicinal Chemistry, 2012, Visentin, Sonja et. al.
Synthesis, Structure-Activity Relationships and Biological Evaluation of Caudatin Derivatives as Novel Anti-Hepatitis B Virus Agents
score: 2.337674, Bioorganic & Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications
score: 2.3345063, Bioorganic & Medicinal Chemistry, 2004, Van Zandt, Michael C. et. al.
Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents
score: 2.3343342, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents
score: 2.3343342, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents
score: 2.3343342, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure–activity relationships of 4-azaindole cores
score: 2.3343177, Bioorganic & Medicinal Chemistry Letters, 2013, Wang, Tao et. al.
Design of EGFR kinase inhibitors: A ligand-based approach and its confirmation with structure-based studies
score: 2.3340042, Bioorganic & Medicinal Chemistry, 2003, Vema, Aparna et. al.
Design, synthesis, antimicrobial, anti-inflammatory and analgesic activity of novel isoxazolyl pyrimido[4,5-b]quinolines and isoxazolyl chromeno[2,3-d]pyrimidin-4-ones
score: 2.3337745, European Journal of Medicinal Chemistry, 2012, Rajanarendar, E. et. al.
New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies
score: 2.3324474, European Journal of Medicinal Chemistry, 2006, Aguirre, Gabriela et. al.
Structure–activity relationship of natural and synthetic coumarins inhibiting the multidrug transporter P-glycoprotein
score: 2.3324349, Bioorganic & Medicinal Chemistry, 2006, Raad, Imad et. al.
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
score: 2.3319637, Bioorganic & Medicinal Chemistry Letters, 2012, Han, Sun-Young et. al.
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
score: 2.3319637, Bioorganic & Medicinal Chemistry Letters, 2012, Han, Sun-Young et. al.
Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter
score: 2.3316191, Bioorganic & Medicinal Chemistry, 2003, Kimura, Makoto et. al.
Synthesis of Tumor-Associated Glycopeptide Antigens
score: 2.3315631, Bioorganic & Medicinal Chemistry, 2002, Brocke, Constanze; Kunz, Horst
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors
score: 2.3312031, Bioorganic & Medicinal Chemistry Letters, 2012, Zych, Andrew J. et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.3304706, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.3304706, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.3304706, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
score: 2.3296783, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Xiao-Dong et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.3292357, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridyl-benzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.3292357, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.3292357, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice
score: 2.3291601, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Liming et. al.
Novel interleukin-5 inhibitors based on hydroxyethylaminomethyl-4H-chromen-4-one scaffold
score: 2.3287092, Bioorganic & Medicinal Chemistry, 2012, Joo, Cheonik et. al.
Discovery of Novel 2-(3-(2-Chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides As Potent HIV-1 Inhibitors Using a Structure-Based Bioisosterism Approach
score: 2.3280813, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
A solid-phase approach to analogues of the antibiotic mureidomycin
score: 2.3270263, Bioorganic & Medicinal Chemistry Letters, 2000, Bozzoli, Andrea et. al.
Facile synthesis and characterization of novel pyrazole-sulfonamides and their inhibition effects on human carbonic anhydrase isoenzymes
score: 2.3257969, Bioorganic & Medicinal Chemistry, 2013, Balseven, Havva et. al.
Synthesis and SAR of Tetrahydroisoquinolines as Rev-erbα agonists
score: 2.325548, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors
score: 2.3254085, Bioorganic & Medicinal Chemistry Letters, 2012, Dong, Ming-xin et. al.
Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors
score: 2.3254085, Bioorganic & Medicinal Chemistry Letters, 2012, Dong, Ming-xin et. al.
Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay
score: 2.324481, Bioorganic & Medicinal Chemistry, 2006, Li, Jian et. al.
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.
score: 2.3243564, Antimicrobial agents and chemotherapy, 2003, Shenai, Bhaskar R et. al.
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors
score: 2.323664, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Zaihui et. al.
Synthesis and Biological Activity of 2-Aminothiazoles as Novel Inhibitors of PGE2 Production in Cells
score: 2.3234602, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Breland et. al.
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1
score: 2.3233555, Bioorganic & Medicinal Chemistry Letters, 2013, Evindar, Ghotas et. al.
Quantitative structure–activity relationships for a series of symmetrical bisquaternary anticancer compounds
score: 2.3229428, Bioorganic & Medicinal Chemistry, 2002, Campos, Joaquı́n M. et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3229197, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors
score: 2.3219732, Bioorganic & Medicinal Chemistry Letters, 2013, Ting, Pauline C. et. al.
Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues
score: 2.3218993, Bioorganic & Medicinal Chemistry, 2012, Roman, Bart I. et. al.
Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold
score: 2.3206476, Bioorganic & Medicinal Chemistry Letters, 2013, Valdenaire, Anja et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3200872, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Structure–affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of α 1 antagonist WB-4101
score: 2.3199347, Bioorganic & Medicinal Chemistry, 2004, Bolchi, Cristiano et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.3189544, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.3189544, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.3189544, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1
score: 2.3180168, Bioorganic & Medicinal Chemistry Letters, 2012, Mougenot, Patrick et. al.
Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose
score: 2.3179169, Bioorganic & Medicinal Chemistry Letters, 2012, Vaidya, Aditya Sudheer et. al.
Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose
score: 2.3179169, Bioorganic & Medicinal Chemistry Letters, 2012, Vaidya, Aditya Sudheer et. al.
Novel potent and selective α vβ 3/α vβ 5 integrin dual antagonists with reduced binding affinity for human serum albumin
score: 2.3166112, European Journal of Medicinal Chemistry, 2006, Raboisson, Pierre et. al.
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
score: 2.3165743, Bioorganic & Medicinal Chemistry Letters, 2012, Winum, Jean-Yves et. al.
Synthesis, biological activity and receptor-based 3-D QSAR study of 3′- N-substituted-3′- N-debenzoylpaclitaxel analogues
score: 2.3157242, Bioorganic & Medicinal Chemistry, 2002, Roh, Eun Joo et. al.
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors
score: 2.3156153, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Zaihui et. al.
Synthesis, structure–activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents
score: 2.313643, Bioorganic & Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Synthesis, structure–activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents
score: 2.313643, Bioorganic & Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents
score: 2.3134382, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Yan et. al.
Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARγ modulators
score: 2.3119313, European Journal of Medicinal Chemistry, 2012, Furukawa, Akihiro et. al.
Convenient synthesis and evaluation of glycosidase inhibitory activity of α- and β-galactose-type valienamines, and some N-alkyl derivatives
score: 2.3112198, Bioorganic & Medicinal Chemistry, 2004, Ogawa, Seiichiro et. al.
Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening
score: 2.3097754, European Journal of Medicinal Chemistry, 2012, Estevão, Mónica S. et. al.
Novel and Potent Anti-malarial Agents
score: 2.3097373, Bioorganic & Medicinal Chemistry, 2002, Brinner, Kristin M et. al.
Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents
score: 2.3095798, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents
score: 2.3095798, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents
score: 2.3095798, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives
score: 2.3080064, Bioorganic & Medicinal Chemistry Letters, 2012, Ikeda, Reiko et. al.
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents
score: 2.3076727, European Journal of Medicinal Chemistry, 2012, Carvalho, Samir A. et. al.
Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening
score: 2.3073263, Bioorganic & Medicinal Chemistry, 2006, Foloppe, Nicolas et. al.
Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues
score: 2.3072656, Bioorganic & Medicinal Chemistry, 2012, Roman, Bart I. et. al.
Design, Synthesis and Evaluation of Novel Zwitterionic Compounds as PPARα/γ Dual Agonists (1)
score: 2.3071787, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Synthesis and biological evaluation of novel (−)-cercosporamide derivatives as potent selective PPARγ modulators
score: 2.3066179, European Journal of Medicinal Chemistry, 2012, Furukawa, Akihiro et. al.
New QSPR study for the prediction of aqueous solubility of drug-like compounds
score: 2.3065304, Bioorganic & Medicinal Chemistry, 2008, Duchowicz, Pablo R. et. al.
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ- and δ-lactams via a ‘catch and release’ protocol
score: 2.3059774, Bioorganic & Medicinal Chemistry, 2006, Musonda, Chitalu C. et. al.
Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents
score: 2.3056485, European Journal of Medicinal Chemistry, 2012, Abbassi, Najat et. al.
Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents
score: 2.3056485, European Journal of Medicinal Chemistry, 2012, Abbassi, Najat et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.3053531, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.3053531, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold
score: 2.3038212, Bioorganic & Medicinal Chemistry Letters, 2013, Valdenaire, Anja et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: Effect of dimerisation on phosphatase inhibition
score: 2.3038055, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: Effect of dimerisation on phosphatase inhibition
score: 2.3038055, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: Effect of dimerisation on phosphatase inhibition
score: 2.3038055, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists
score: 2.3024, Bioorganic & Medicinal Chemistry, 1998, Robarge, Kirk D. et. al.
Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand
score: 2.3017834, Bioorganic & Medicinal Chemistry, 2006, Miura, Masanori et. al.
Design and analysis of molecular motifs for specific recognition of RNA
score: 2.3012748, Bioorganic & Medicinal Chemistry, 1997, Fernandez-Saiz, Ke Li M. et. al.
Synthesis, characterization and antimalarial activity of quinoline–pyrimidine hybrids
score: 2.3006159, Bioorganic & Medicinal Chemistry, 2013, Pretorius, Stefan I. et. al.
Novel triazines as potent and selective phosphodiesterase 10A inhibitors
score: 2.3001789, Bioorganic & Medicinal Chemistry Letters, 2012, Malamas, Michael S. et. al.
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases
score: 2.2995765, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Tao et. al.
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties
score: 2.2992818, Bioorganic & Medicinal Chemistry Letters, 2013, Butini, Stefania et. al.
Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold
score: 2.2986835, European Journal of Medicinal Chemistry, 2012, Al-Horani, Rami A.; Mehta, Akul Y.; Desai, Umesh R.
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors
score: 2.2984298, Bioorganic & Medicinal Chemistry Letters, 2012, Basu, Sujay et. al.
Structure–activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors
score: 2.2981661, Bioorganic & Medicinal Chemistry, 2004, Ockey, Denise A et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridyl-benzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.297908, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.
score: 2.2976833, Antimicrobial agents and chemotherapy, 2002, Hackbarth, Corinne J et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.2961445, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.2956731, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.2956731, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.2956731, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
Pharmacophores modeling in terms of prediction of theoretical physico-chemical properties and verification by experimental correlations of novel coumarin derivatives produced via Betti’s protocol
score: 2.2953207, European Journal of Medicinal Chemistry, 2010, Parvez, Ali et. al.
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability
score: 2.2951864, Bioorganic & Medicinal Chemistry, 2006, Staas, Donnette D. et. al.
Structure-based optimization of aminopyridines as PKCθ inhibitors
score: 2.2947119, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Juan-Miguel et. al.
Structure-based optimization of aminopyridines as PKCθ inhibitors
score: 2.2947119, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Juan-Miguel et. al.
Chiral 3,3′-(1,2-Ethanediyl)-bis[2-(3,4-dimethoxyphenyl)-4-thiazolidinones] with anti-inflammatory activity. Part 11: Evaluation of COX-2 selectivity and modelling
score: 2.2937075, Bioorganic & Medicinal Chemistry, 2003, Vigorita, M.G et. al.
Automated generation of turn mimetics: Proof of concept study for the MC4 receptor
score: 2.2914109, Bioorganic & Medicinal Chemistry, 2012, Baber, J. Christian et. al.
Automated generation of turn mimetics: Proof of concept study for the MC4 receptor
score: 2.2914109, Bioorganic & Medicinal Chemistry, 2012, Baber, J. Christian et. al.
Automated generation of turn mimetics: Proof of concept study for the MC4 receptor
score: 2.2914109, Bioorganic & Medicinal Chemistry, 2012, Baber, J. Christian et. al.
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.2889956, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.2889956, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
3-D-QSAR Analysis of N-(3-Acyloxy-2-benzylpropyl)- N′-dihydroxytetrahydrobenzazepine and Tetrahydroisoquinoline and N-(3-Acyloxy-2-benzylpropyl)- N′-(4-hydroxy-3-methoxybenzyl) Thioureas Analogues as Potent Vanilloid Receptor Ligands
score: 2.288465, Bioorganic & Medicinal Chemistry, 2002, Kim, Ki H.
Synthesis, pharmacology and molecular modeling of N-substituted 2-phenyl-indoles and benzimidazoles as potent GABA A agonists
score: 2.2874282, European Journal of Medicinal Chemistry, 2006, Falcó, José Luis et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.2874207, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4 H-pyrrolo[1,2- b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
score: 2.2873349, Bioorganic & Medicinal Chemistry Letters, 2004, Scott Sawyer, J. et. al.
3D QSAR CoMFA/CoMSIA, molecular docking and molecular dynamics studies of fullerene-based HIV-1 PR inhibitors
score: 2.2872006, Bioorganic & Medicinal Chemistry Letters, 2008, Durdagi, Serdar et. al.
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors
score: 2.2869479, Bioorganic & Medicinal Chemistry Letters, 2012, Zych, Andrew J. et. al.
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors
score: 2.2869479, Bioorganic & Medicinal Chemistry Letters, 2012, Zych, Andrew J. et. al.
Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity
score: 2.2855378, Bioorganic & Medicinal Chemistry Letters, 2012, Ryabtsova, Oxana et. al.
Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity
score: 2.2855378, Bioorganic & Medicinal Chemistry Letters, 2012, Ryabtsova, Oxana et. al.
Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity
score: 2.2855378, Bioorganic & Medicinal Chemistry Letters, 2012, Ryabtsova, Oxana et. al.
Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors
score: 2.2853772, Bioorganic & Medicinal Chemistry, 1997, Reuveni, Hadas et. al.
Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents
score: 2.2850944, Bioorganic & Medicinal Chemistry, 2005, Velázquez, Carlos et. al.
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
score: 2.2849291, Bioorganic & Medicinal Chemistry Letters, 2012, Winum, Jean-Yves et. al.
3,3′-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding
score: 2.2846124, Bioorganic & Medicinal Chemistry Letters, 2012, Weiser, Patrick T. et. al.
Synthesis and evaluation of molluscicidal and larvicidal activities of some novel enaminones derived from 4-hydroxyquinolinones: Part IX
score: 2.2843727, Bioorganic & Medicinal Chemistry, 2005, Abass, Mohamed; Mostafa, Bayaumy B.
A novel aminopeptidase N inhibitor developed by virtual screening approach
score: 2.2840213, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Jinhong et. al.
Anticancer thiopyrano[2,3- d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies
score: 2.2833627, Bioorganic & Medicinal Chemistry, 2006, Lesyk, Roman et. al.
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4- N-methylamino-4,5,6,7-tetrahydrobenzo[ d]isoxazol-3-ol analogues
score: 2.2833355, Bioorganic & Medicinal Chemistry, 2005, Clausen, Rasmus P. et. al.
5-Substituted-1 H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods
score: 2.281937, Bioorganic & Medicinal Chemistry, 2002, Herr, R.Jason
Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors
score: 2.2795197, Bioorganic & Medicinal Chemistry Letters, 2012, Vontzalidou, Argyro et. al.
Part 3: Synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid
score: 2.2774589, Bioorganic & Medicinal Chemistry, 2005, Hazeldine, Stuart T. et. al.
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo–keto reductase AKR1C3
score: 2.2771984, Bioorganic & Medicinal Chemistry Letters, 2012, Sinreih, Maša et. al.
5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials
score: 2.2768828, Bioorganic & Medicinal Chemistry Letters, 2012, Zvarec, Ondrej et. al.
Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1
score: 2.2766853, Bioorganic & Medicinal Chemistry, 2012, Mikstacka, Renata et. al.
Synthesis and in vitro antitumor activity of novel scopoletin derivatives
score: 2.2752789, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Wukun et. al.
Identification of Novel Series of Pyrazole and Indole-Urea based DFG-out PYK2 Inhibitors
score: 2.2722694, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Synthesis of gatifloxacin derivatives and their biological activities againstMycobacterium lepraeandMycobacterium tuberculosis
score: 2.2721256, Bioorganic & Medicinal Chemistry, 2013, Gomez, Catherine et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.2714266, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.2714266, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.2714266, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
score: 2.2699405, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)- podophyllotoxin derivatives
score: 2.2697188, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Design and synthesis of C-linked fucosides as inhibitors of E-selectin
score: 2.2691754, Bioorganic & Medicinal Chemistry, 1996, Uchiyama, Taketo et. al.
Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors
score: 2.2689849, Bioorganic & Medicinal Chemistry Letters, 2009, Shi, Shuhao et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.2687011, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 2.2671979, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 2.2671979, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 2.2671979, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
De novo design and synthesis of HIV-1 integrase inhibitors
score: 2.2666868, Bioorganic & Medicinal Chemistry, 2004, Makhija, Mahindra T et. al.
3D-QSAR and docking studies of aldehyde inhibitors of human cathepsin K
score: 2.2666475, Bioorganic & Medicinal Chemistry, 2006, Pan, Xulin et. al.
Design, synthesis, computational and biological evaluation of new anxiolytics
score: 2.2652463, Bioorganic & Medicinal Chemistry, 2004, Geronikaki, Athina et. al.
Three-dimensional quantitative structure-activity relationship and comparative molecular field analysis of dipeptide hydroxamic acid Helicobacter pylori urease inhibitors.
score: 2.264468, Antimicrobial agents and chemotherapy, 2002, Mishra, Hetal; Parrill, Abby L; Williamson, John S
3D-QSAR Study on dihydro-1,3,5-triazines and their spiro derivatives as DHFR inhibitors by comparative molecular field analysis (CoMFA)
score: 2.2639476, Bioorganic & Medicinal Chemistry Letters, 2012, Ma, Xiang; Xiang, Guangya; Yap, Chun-Wei; Chui, Wai-Keung
3D-QSAR Study on dihydro-1,3,5-triazines and their spiro derivatives as DHFR inhibitors by comparative molecular field analysis (CoMFA)
score: 2.2639476, Bioorganic & Medicinal Chemistry Letters, 2012, Ma, Xiang; Xiang, Guangya; Yap, Chun-Wei; Chui, Wai-Keung
Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): Molecular docking and 3D-QSAR analyses on DHDMBF analogues
score: 2.2633546, Bioorganic & Medicinal Chemistry, 2006, Zheng, Mingyue et. al.
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton
score: 2.2621792, Bioorganic & Medicinal Chemistry, 2012, Liu, Chang et. al.
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton
score: 2.2621792, Bioorganic & Medicinal Chemistry, 2012, Liu, Chang et. al.
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton
score: 2.2621792, Bioorganic & Medicinal Chemistry, 2012, Liu, Chang et. al.
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.26163, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors
score: 2.2611598, Bioorganic & Medicinal Chemistry Letters, 2012, Bell, Kathryn et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2611352, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Synthesis and structure activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent beta isoform selective phosphatidylinositol 3-kinase inhibitors
score: 2.2609097, Bioorganic & Medicinal Chemistry Letters, 2012, Sanchez, Robert M. et. al.
New farnesyltransferase inhibitors in the phenothiazine series
score: 2.2606227, Bioorganic & Medicinal Chemistry Letters, 2012, Belei, Dalila et. al.
New farnesyltransferase inhibitors in the phenothiazine series
score: 2.2606227, Bioorganic & Medicinal Chemistry Letters, 2012, Belei, Dalila et. al.
New farnesyltransferase inhibitors in the phenothiazine series
score: 2.2606227, Bioorganic & Medicinal Chemistry Letters, 2012, Belei, Dalila et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part IV: Preliminary control of α vβ 3 selectivity by meta-oriented substitution
score: 2.2600891, Bioorganic & Medicinal Chemistry, 2006, Kubota, Dai et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 2.2597224, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
score: 2.2587307, Bioorganic & Medicinal Chemistry, 2001, McLay, Iain M. et. al.
Synthesis and biological activities of polyquinoline derivatives: New Bcl-2 family protein modulators
score: 2.2577342, European Journal of Medicinal Chemistry, 2012, Saugues, Emmanuelle et. al.
Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline
score: 2.2572601, Bioorganic & Medicinal Chemistry, 2012, Casagrande, Manolo et. al.
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries
score: 2.2560064, Bioorganic & Medicinal Chemistry Letters, 2012, Rahman, Khondaker M. et. al.
Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry
score: 2.2553654, Bioorganic & Medicinal Chemistry, 1997, Hagishita, Sanji et. al.
A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents
score: 2.255284, European Journal of Medicinal Chemistry, 2012, Kumar, Dalip; Kumar, N. Maruthi; Noel, Brett; Shah, Kavita
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2549718, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2549718, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2549718, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
score: 2.2549365, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
score: 2.2549365, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Antifungal properties of new series of quinoline derivatives
score: 2.2540014, Bioorganic & Medicinal Chemistry, 2006, Musiol, Robert et. al.
Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone
score: 2.2538505, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Xianfeng et. al.
Discovery of 4,5-Diphenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human V 1A Receptor
score: 2.2529958, Bioorganic & Medicinal Chemistry, 2002, Kakefuda, Akio et. al.
2-Aminothiophenes as building blocks in heterocyclic synthesis: Synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives
score: 2.2519538, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
2-Aminothiophenes as building blocks in heterocyclic synthesis: Synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives
score: 2.2519538, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
2-Aminothiophenes as building blocks in heterocyclic synthesis: Synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives
score: 2.2519538, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2514456, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Design, synthesis and antibacterial activities of a series of new 2-oxaisocephems
score: 2.2512502, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Jianbo et. al.
Design of tetrapeptide ligands as inhibitors of the Src SH2 domain
score: 2.250577, Bioorganic & Medicinal Chemistry, 2004, Nam, Nguyen-Hai et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.2503595, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
Enhanced cell permeability of kojic acid–phenylalanine amide with metal complex
score: 2.2499874, Bioorganic & Medicinal Chemistry Letters, 2010, Kwak, Seon-Yeong et. al.
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist
score: 2.2498587, Bioorganic & Medicinal Chemistry Letters, 2005, Weigand, Stefan et. al.
Understanding the antitumor activity of novel tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors using CoMFA and CoMSIA
score: 2.2492938, European Journal of Medicinal Chemistry, 2006, Puntambekar, D.S.; Giridhar, R.; Yadav, M.R.
Novel structural insights for drug design of selective 5-HT 2C inverse agonists from a ligand-biased receptor model
score: 2.2486241, European Journal of Medicinal Chemistry, 2010, Renault, Nicolas et. al.
Quantitative structure-activity relationship studies of a series of sulfa drugs as inhibitors of Pneumocystis carinii dihydropteroate synthetase.
score: 2.2471503, Antimicrobial agents and chemotherapy, 1998, Johnson, T; Khan, I A; Avery, M A; Grant, J; Meshnick, S R
Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
score: 2.246362, Bioorganic & Medicinal Chemistry Letters, 2006, Pereira, Raquel et. al.
Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic—salinomycin
score: 2.246003, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam et. al.
Synthesis and anti-inflammatory activity of a series of N-substituted naproxen glycolamides: Nitric oxide-donor naproxen prodrugs
score: 2.2452119, Bioorganic & Medicinal Chemistry, 2006, Ranatunge, Ramani R. et. al.
Short synthesis and antimalarial activity of fagaronine
score: 2.2439677, Bioorganic & Medicinal Chemistry, 2012, Rivaud, M. et. al.
Short synthesis and antimalarial activity of fagaronine
score: 2.2439677, Bioorganic & Medicinal Chemistry, 2012, Rivaud, M. et. al.
Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin
score: 2.2432805, Bioorganic & Medicinal Chemistry Letters, 2013, Manohar, Sunny et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2432149, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2432149, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria
score: 2.2428249, Bioorganic & Medicinal Chemistry, 2001, Lee, Chi Sing et. al.
Design, synthesis and molecular docking of α,β-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity
score: 2.2418683, Bioorganic & Medicinal Chemistry, 2013, Xu, Yun-Yun et. al.
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors
score: 2.2415612, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors
score: 2.2415612, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors
score: 2.2415612, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.2415446, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
score: 2.2395414, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
score: 2.2395414, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
score: 2.2395414, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
Design, Prins-cyclization reaction promoting diastereoselective synthesis of 10 new tetrahydropyran derivatives and in vivo antinociceptive evaluations
score: 2.239081, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Design, Prins-cyclization reaction promoting diastereoselective synthesis of 10 new tetrahydropyran derivatives and in vivo antinociceptive evaluations
score: 2.239081, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Isochromanone-based urotensin-II receptor agonists
score: 2.2387859, Bioorganic & Medicinal Chemistry, 2005, Lehmann, Fredrik et. al.
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
score: 2.2380216, Bioorganic & Medicinal Chemistry, 2012, B-Rao, Chandrika et. al.
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
score: 2.2380216, Bioorganic & Medicinal Chemistry, 2012, B-Rao, Chandrika et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.2368958, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
A novel series of L-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study
score: 2.2363152, European Journal of Medicinal Chemistry, 2012, Huang, Dawei; Li, Xiaohui; Wei, Yingdong; Xiu, Zhilong
A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study
score: 2.2355691, European Journal of Medicinal Chemistry, 2012, Huang, Dawei; Li, Xiaohui; Wei, Yingdong; Xiu, Zhilong
Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold
score: 2.2342145, Bioorganic & Medicinal Chemistry Letters, 2013, Gao, Ling-Jie et. al.
Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase
score: 2.2320816, Bioorganic & Medicinal Chemistry Letters, 2012, Xin, Botao et. al.
Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase
score: 2.2320816, Bioorganic & Medicinal Chemistry Letters, 2012, Xin, Botao et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part 2: Synthesis of potent α vβ 3/α IIbβ 3 dual antagonists
score: 2.2315461, Bioorganic & Medicinal Chemistry, 2006, Ishikawa, Minoru et. al.
7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1 H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V 2 receptor antagonist
score: 2.2310612, Bioorganic & Medicinal Chemistry, 1999, Kondo, Kazumi et. al.
Rapid microwave-assisted fluorination yielding novel 5′-deoxy-5′-fluorouridine derivatives
score: 2.2302321, Bioorganic & Medicinal Chemistry Letters, 2006, Le, H. Phuoc; Müller, Christa E.
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents
score: 2.2300741, European Journal of Medicinal Chemistry, 2012, Tonk, Rajiv Kumar et. al.
A Novel Series of Pyrazolylpiperidine N-Type Calcium Channel Blockers
score: 2.2289401, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.2282979, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors
score: 2.2271863, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Kui et. al.
Potent and Selective Inhibitors of PI3Kδ: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
score: 2.2270825, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
score: 2.225402, Bioorganic & Medicinal Chemistry Letters, 2012, Bonn, Peter et. al.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
score: 2.225402, Bioorganic & Medicinal Chemistry Letters, 2012, Bonn, Peter et. al.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
score: 2.225402, Bioorganic & Medicinal Chemistry Letters, 2012, Bonn, Peter et. al.
A natural product inspired hybrid approach towards the synthesis of novel pentamidine based scaffolds as potential anti-parasitic agents
score: 2.2252982, Bioorganic & Medicinal Chemistry Letters, 2013, Tyagi, Vikas et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
score: 2.2252869, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Tiansheng et. al.
Discovery of Benzothiazole Guanidines as Novel Inhibitors of Thrombin and Trypsin IV
score: 2.2251341, Bioorganic & Medicinal Chemistry Letters, 2012, Karle, Michael; Knecht, Wolfgang; Xue, Yafeng
Synthesis of an α-kojibiosyl substituted glycerol teichoic acid hexamer
score: 2.2243956, Bioorganic & Medicinal Chemistry, 2010, Hogendorf, Wouter F.J. et. al.
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
score: 2.2238321, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Substituted hepta-1,6-dien-3-ones with green/fruity odours green/galbanum olfactophore model
score: 2.2237475, Bioorganic & Medicinal Chemistry, 2003, Bajgrowicz, Jerzy A; Berg-Schultz, Katja; Brunner, Gerhard
O-Aryl α,β-D-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2236064, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy
score: 2.2235606, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yuusuke et. al.
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy
score: 2.2235606, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yuusuke et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 2.2233331, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 2.2233331, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR
score: 2.2224282, Bioorganic & Medicinal Chemistry Letters, 2012, Bregman, Howard et. al.
Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Synthesis and structure–activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives
score: 2.2223436, Bioorganic & Medicinal Chemistry, 2005, Masuda, Naoyuki et. al.
Synthesis of 6-Substituted 9-Methoxy-11H-indeno[1,2-c]quinoline-11-one Derivatives as Potential Anticancer Agents
score: 2.2218378, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
score: 2.2216095, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel J. et. al.
Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm
score: 2.2216086, Bioorganic & Medicinal Chemistry Letters, 2006, Yuan, Hongbin; Petukhov, Pavel A.
Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents
score: 2.2215112, Bioorganic & Medicinal Chemistry, 1997, Li, Hui-Yin et. al.
Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY
score: 2.2214809, Bioorganic & Medicinal Chemistry, 2012, Papst, Stefanie et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.2207816, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.2207816, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.2207816, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-α-threofuranosyl ring systems: interactions with P2Y receptors
score: 2.2205305, Bioorganic & Medicinal Chemistry, 2004, Ohno, Michihiro et. al.
Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity
score: 2.2204548, Bioorganic & Medicinal Chemistry, 2003, Moosavi-Movahedi, Ali A et. al.
Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 2.2196644, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 2.2196644, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 2.2196644, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors
score: 2.219609, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors
score: 2.219609, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors
score: 2.219609, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
Synthesis and structure–activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors
score: 2.2196075, Bioorganic & Medicinal Chemistry Letters, 2012, Sanchez, Robert M. et. al.
Synthesis and structure–activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors
score: 2.2196075, Bioorganic & Medicinal Chemistry Letters, 2012, Sanchez, Robert M. et. al.
Identification of novel chromenone derivatives as interleukin-5 inhibitors
score: 2.2190259, European Journal of Medicinal Chemistry, 2013, Venkateswararao, Eeda et. al.
Identification of novel chromenone derivatives as interleukin-5 inhibitors
score: 2.2190259, European Journal of Medicinal Chemistry, 2013, Venkateswararao, Eeda et. al.
Design and synthesis of Pictet–Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death
score: 2.2162141, Bioorganic & Medicinal Chemistry Letters, 2012, Skouta, Rachid et. al.
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450
score: 2.2138429, Bioorganic & Medicinal Chemistry, 2006, Labrie, Philippe et. al.
C 17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C 17,20-lyase inhibitors
score: 2.2135427, Bioorganic & Medicinal Chemistry, 2004, Matsunaga, Nobuyuki et. al.
A general method for the synthesis of aryl [ 11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression
score: 2.2129793, Bioorganic & Medicinal Chemistry Letters, 2005, Majo, Vattoly J. et. al.
O-Aryl α,β-d-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2122579, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
O-Aryl α,β-d-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2122579, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
O-Aryl α,β-d-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2122579, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
Analogs of N′-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 2.2117791, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Analogs of N′-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 2.2117791, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Selective anti-tubercular purines: Synthesis and chemotherapeutic properties of 6-aryl- and 6-heteroaryl-9-benzylpurines
score: 2.210964, Bioorganic & Medicinal Chemistry, 2005, Brændvang, Morten; Gundersen, Lise-Lotte
Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety
score: 2.2108457, Bioorganic & Medicinal Chemistry Letters, 2012, Arai, Tadamasa et. al.
Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety
score: 2.2108457, Bioorganic & Medicinal Chemistry Letters, 2012, Arai, Tadamasa et. al.
Design, synthesis and structure–activity relationships of novel benzoxazolone derivatives as 18kDa translocator protein (TSPO) ligands
score: 2.2107014, Bioorganic & Medicinal Chemistry, 2012, Fukaya, Takayuki et. al.
Novel 3-substituted-1-aryl-5-phenyl-6-anilinopyrazolo[3,4-d]pyrimidin-4-ones: Docking, synthesis and pharmacological evaluation as a potential anti-inflammatory agents
score: 2.2103105, Bioorganic & Medicinal Chemistry Letters, 2012, Yewale, Sandeep B. et. al.
Novel 3-substituted-1-aryl-5-phenyl-6-anilinopyrazolo[3,4-d]pyrimidin-4-ones: Docking, synthesis and pharmacological evaluation as a potential anti-inflammatory agents
score: 2.2103105, Bioorganic & Medicinal Chemistry Letters, 2012, Yewale, Sandeep B. et. al.
Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity
score: 2.2088508, Bioorganic & Medicinal Chemistry, 2012, Erić, Slavica et. al.
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood–brain barrier choline transporter
score: 2.2081262, Bioorganic & Medicinal Chemistry, 2005, Geldenhuys, Werner J. et. al.
Synthesis and Docking Studies of Novel Antitumor Benzimidazoles
score: 2.2074251, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Identification ofN-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual acting α4β1 and α4β7 receptor antagonists
score: 2.2062112, Bioorganic & Medicinal Chemistry Letters, 2013, Tilley, Jefferson W. et. al.
Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques
score: 2.2060498, Bioorganic & Medicinal Chemistry Letters, 2005, Gil, Carmen; Dorronsoro, Isabel; Castro, Ana; Martinez, Ana
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.2053586, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Design, synthesis and evaluation of novel metalloproteinase inhibitors based on l-tyrosine scaffold
score: 2.2051207, Bioorganic & Medicinal Chemistry, 2012, Cheng, Xian-Chao et. al.
Database of bioactive ring systems with calculated properties and its use in bioisosteric design and scaffold hopping
score: 2.2048883, Bioorganic & Medicinal Chemistry, 2012, Ertl, Peter
Analogs of N′-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 2.2037959, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.2029379, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.2029379, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.2029379, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
A novel class of small-molecule Caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2029285, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.2028581, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.2028581, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.2028581, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Small molecule inhibitors of the HPV16-E6 interaction with caspase 8
score: 2.2026967, Bioorganic & Medicinal Chemistry Letters, 2012, Yuan, Chung-Hsiang et. al.
Design and Synthesis of Carbamate and Thiocarbamate Derivatives and Their Inhibitory Activities of NO Production in LPS Activated Macrophages
score: 2.201709, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Guo Hua et. al.
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: Methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones
score: 2.2014997, Bioorganic & Medicinal Chemistry, 2012, Manivannan, E.; Chaturvedi, S.C.
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: Methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones
score: 2.2014997, Bioorganic & Medicinal Chemistry, 2012, Manivannan, E.; Chaturvedi, S.C.
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: Methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones
score: 2.2014997, Bioorganic & Medicinal Chemistry, 2012, Manivannan, E.; Chaturvedi, S.C.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.2013219, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Computational design of novel, high-affinity neuraminidase inhibitors for H5N1 avian influenza virus
score: 2.2011454, European Journal of Medicinal Chemistry, 2010, Park, Jin Woo; Jo, Won Ho
Synthesis, pharmacological evaluation, and structure–activity relationships of benzopyran derivatives with potent SERM activity
score: 2.2004418, Bioorganic & Medicinal Chemistry, 2004, Amari, Gabriele et. al.
Drug discovery and development for neglected parasitic diseases.
score: 2.2001399, Nature chemical biology, 2006, Renslo, Adam R; McKerrow, James H
5-(1,3-Benzothiazol-6-yl)-4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazole Derivatives as Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitors
score: 2.1994156, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design
score: 2.1992734, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design
score: 2.1992734, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Novel prodrug approach to amprenavir-based HIV-1 protease inhibitors via O→ N acyloxy migration of P1 moiety
score: 2.1985691, Bioorganic & Medicinal Chemistry Letters, 2003, Kazmierski, Wieslaw M et. al.
Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3- d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents
score: 2.1983363, Bioorganic & Medicinal Chemistry, 2006, Gangjee, Aleem; Yang, Jie; Queener, Sherry F.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor
score: 2.1978001, Bioorganic & Medicinal Chemistry Letters, 2012, Finlay, M. Raymond V. et. al.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor
score: 2.1978001, Bioorganic & Medicinal Chemistry Letters, 2012, Finlay, M. Raymond V. et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.197635, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.197635, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.197635, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure–activity study
score: 2.197571, Bioorganic & Medicinal Chemistry, 2012, Chorell, Erik et. al.
Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure–activity study
score: 2.197571, Bioorganic & Medicinal Chemistry, 2012, Chorell, Erik et. al.
Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases
score: 2.1968837, European Journal of Medicinal Chemistry, 2009, Politi, Aggeliki et. al.
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi
score: 2.1966838, Bioorganic & Medicinal Chemistry, 2006, Leite, Ana Cristina Lima et. al.
Structure–activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity
score: 2.1961809, Bioorganic & Medicinal Chemistry, 2006, Xue, Fengtian; Seto, Christopher T.
Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
score: 2.1951708, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
score: 2.1951708, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
score: 2.1951708, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases
score: 2.1946386, Bioorganic & Medicinal Chemistry, 2006, Njar, Vincent C.O. et. al.
β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study
score: 2.1940386, Bioorganic & Medicinal Chemistry Letters, 2012, Du, Jinfa et. al.
Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design
score: 2.1938363, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Identification of Small-Molecule Inhibitors of the Steroidogenic Acute Regulatory Protein (STARD1) by Structure-Based Design
score: 2.1938363, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists
score: 2.1921802, Bioorganic & Medicinal Chemistry Letters, 2013, Cai, Chaozhong et. al.
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
score: 2.1919358, Bioorganic & Medicinal Chemistry, 2005, Shie, Jiun-Jie et. al.
Synthesis and biological evaluation of novel (−)-cercosporamide derivatives as potent selective PPARγ modulators
score: 2.1915685, European Journal of Medicinal Chemistry, 2012, Furukawa, Akihiro et. al.
Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents
score: 2.190599, European Journal of Medicinal Chemistry, 2012, Abbassi, Najat et. al.
Computer-aided design of non sulphonyl COX-2 inhibitors
score: 2.1899489, Bioorganic & Medicinal Chemistry, 2003, Chakraborti, Asit K.; Thilagavathi, R.
12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
score: 2.1892559, European Journal of Medicinal Chemistry, 2012, Liao, Sheng-Rong et. al.
12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
score: 2.1892559, European Journal of Medicinal Chemistry, 2012, Liao, Sheng-Rong et. al.
12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
score: 2.1892559, European Journal of Medicinal Chemistry, 2012, Liao, Sheng-Rong et. al.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
score: 2.1883717, Bioorganic & Medicinal Chemistry Letters, 2012, He, Hai-Bing et. al.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
score: 2.1883717, Bioorganic & Medicinal Chemistry Letters, 2012, He, Hai-Bing et. al.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
score: 2.1883717, Bioorganic & Medicinal Chemistry Letters, 2012, He, Hai-Bing et. al.
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening
score: 2.1878976, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Peng et. al.
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening
score: 2.1878976, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Peng et. al.
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening
score: 2.1878976, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Peng et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1875095, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.1874936, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.1874936, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.1874936, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Combinatorial synthesis and biological evaluation of Library of small-molecule Ser/Thr-protein phosphatase inhibitors
score: 2.187427, Bioorganic & Medicinal Chemistry, 1997, Wipf, Peter et. al.
Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues
score: 2.1869104, Bioorganic & Medicinal Chemistry, 2003, Caballero, Esther et. al.
Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists
score: 2.1866722, Bioorganic & Medicinal Chemistry Letters, 2012, Berezowska, Irena et. al.
Structure–activity relationship study on benzoic acid part of diphenylamine-based retinoids
score: 2.1856774, Bioorganic & Medicinal Chemistry Letters, 2013, Ohta, Kiminori et. al.
CoMFA and docking studies on triazolopyridine oxazole derivatives as p38 MAP kinase inhibitors
score: 2.1855682, European Journal of Medicinal Chemistry, 2008, Shashi Nayana, M. Ravi et. al.
COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates
score: 2.1854795, Bioorganic & Medicinal Chemistry, 2012, Fagan, Vincent et. al.
COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates
score: 2.1854795, Bioorganic & Medicinal Chemistry, 2012, Fagan, Vincent et. al.
COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates
score: 2.1854795, Bioorganic & Medicinal Chemistry, 2012, Fagan, Vincent et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.1853926, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.1853926, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.1853926, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90
score: 2.1838575, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Kenneth H. et. al.
Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives
score: 2.1834071, Bioorganic & Medicinal Chemistry Letters, 2012, Ohnmacht, Stephan A. et. al.
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents
score: 2.1831766, European Journal of Medicinal Chemistry, 2012, Tonk, Rajiv Kumar et. al.
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles
score: 2.1831669, Bioorganic & Medicinal Chemistry, 2006, Yonetoku, Yasuhiro et. al.
Synthesis of highly potent novel anti-tubercular isoniazid analogues with preliminary pharmacokinetic evaluation
score: 2.1824634, Bioorganic & Medicinal Chemistry Letters, 2012, Ramani, Addepalli Venkata et. al.
Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
score: 2.182462, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors
score: 2.1822944, Bioorganic & Medicinal Chemistry, 2006, Amélia Santos, M. et. al.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
score: 2.1817967, Bioorganic & Medicinal Chemistry Letters, 2012, Hsu, John T.-A. et. al.
Docking-based 3D-QSAR study of HIV-1 integrase inhibitors
score: 2.1809192, European Journal of Medicinal Chemistry, 2009, Gupta, Pawan; Roy, Nilanjan; Garg, Prabha
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.1801538, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
score: 2.1789271, Bioorganic & Medicinal Chemistry Letters, 2012, Jiao, XianYun et. al.
Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles
score: 2.1774187, Bioorganic & Medicinal Chemistry, 2012, Fajkusova, Dagmar et. al.
Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles
score: 2.1774187, Bioorganic & Medicinal Chemistry, 2012, Fajkusova, Dagmar et. al.
Hybrid fluorescent conjugates of COX-2 inhibitors: Search for a COX-2 isozyme imaging cancer biomarker
score: 2.1764532, Bioorganic & Medicinal Chemistry Letters, 2013, Bhardwaj, Atul et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.1754596, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.1754596, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.1754596, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives
score: 2.1745399, European Journal of Medicinal Chemistry, 2013, Verones, Valérie et. al.
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives
score: 2.1745399, European Journal of Medicinal Chemistry, 2013, Verones, Valérie et. al.
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.1739462, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
Antimycobacterial activity: A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines
score: 2.1738528, Bioorganic & Medicinal Chemistry Letters, 2012, Wei, Ang Chee et. al.
Structure–activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors
score: 2.172509, Bioorganic & Medicinal Chemistry Letters, 2010, Cuny, Gregory D. et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.1724564, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.1724564, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.1724564, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues
score: 2.1718034, Bioorganic & Medicinal Chemistry, 2000, Nakagawa, Yoshiaki et. al.
Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners
score: 2.171364, European Journal of Medicinal Chemistry, 2012, Abu-Aisheh, Marwa N. et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.1711135, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.1709741, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.1709741, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.1709741, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB 1 and CB 2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB 2 receptor agonists
score: 2.1706436, Bioorganic & Medicinal Chemistry, 2005, Huffman, John W. et. al.
[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers
score: 2.1698846, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Min et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines –σ1 receptor ligands with modified benzene-N-distance
score: 2.1688492, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines –σ1 receptor ligands with modified benzene-N-distance
score: 2.1688492, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
Evaluation of and -Aryl-Substitutions and Central Scaffold Modifications on Diphenyl Substituted Alkanes as 5-Lipoxygenase Activating Protein Inhibitors
score: 2.1681838, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.1679041, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.1679041, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.1679041, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors
score: 2.167898, Bioorganic & Medicinal Chemistry Letters, 2012, Jonckers, Tim H.M. et. al.
Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents
score: 2.167072, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hao et. al.
A microwave-assisted, facile, regioselective Friedländer synthesis and antitubercular evaluation of 2,9-diaryl-2,3-dihydrothieno-[3,2- b]quinolines
score: 2.1667277, European Journal of Medicinal Chemistry, 2010, Balamurugan, Kamaraj et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.1664305, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Recent developments in the identification of novel oxazolidinone antibacterial agents
score: 2.1655725, Bioorganic & Medicinal Chemistry, 2006, Renslo, Adam R.; Luehr, Gary W.; Gordeev, Mikhail F.
Synthesis and Inhibitory Activity of Novel Tri- and Tetracyclic Quinolines against Topoisomerases
score: 2.1652472, Bioorganic & Medicinal Chemistry, 1998, Sui, Zhihua et. al.
Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors
score: 2.1651355, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Yanyang et. al.
Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents
score: 2.1649809, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hao et. al.
Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents
score: 2.1649809, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hao et. al.
QSAR study for a novel series of ortho disubstituted phenoxy analogues of α 1-adrenoceptor antagonist WB4101
score: 2.1649063, European Journal of Medicinal Chemistry, 2006, Pallavicini, M. et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1643566, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and pharmacological evaluation of substituted naphth[1,2,3- de]isoquinolines (dinapsoline analogues) as D 1 and D 2 dopamine receptor ligands
score: 2.1634294, Bioorganic & Medicinal Chemistry, 2003, Qandil, Amjad M et. al.
Structure aided design of chimeric antibiotics
score: 2.1627336, Bioorganic & Medicinal Chemistry Letters, 2012, Karoli, Tomislav et. al.
Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.1619787, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.1619787, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.1619787, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents
score: 2.1618087, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere
score: 2.161767, Bioorganic & Medicinal Chemistry, 2003, Uddin, Md.Jashim; Rao, P.N.Praveen; Knaus, Edward E.
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.1614231, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.1614231, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.1614231, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.1604756, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.1604756, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.1604756, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
SAR and biological evaluation of novel trans-3,4-dimethyl-4-arylpiperidine derivatives as opioid antagonists
score: 2.1599058, Bioorganic & Medicinal Chemistry Letters, 2005, Díaz, Nuria et. al.
Synthesis and structure–activity relationships of metal–ligand complexes that potently inhibit cell migration
score: 2.1598691, Bioorganic & Medicinal Chemistry Letters, 2008, Beshir, Anwar B. et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1597813, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1597813, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1597813, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Identification ofN-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4–beta1 and alpha4–beta7 receptor antagonists
score: 2.1596395, Bioorganic & Medicinal Chemistry Letters, 2013, Sidduri, Achyutharao et. al.
Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects
score: 2.159366, Bioorganic & Medicinal Chemistry Letters, 2012, Liao, Vivian; Liu, Tao; Codd, Rachel
Synthesis and biological evaluation of acyclic triaryl ( Z)-olefins possessing a 3,5-di- tert-butyl-4-hydroxyphenyl pharmacophore: Dual inhibitors of cyclooxygenases and lipoxygenases
score: 2.1592251, Bioorganic & Medicinal Chemistry, 2006, Moreau, Anne; Praveen Rao, P.N.; Knaus, Edward E.
COX inhibitors Indomethacin and Sulindac derivatives as antiproliferative agents: Synthesis, biological evaluation, and mechanism investigation
score: 2.1586182, European Journal of Medicinal Chemistry, 2012, Chennamaneni, Snigdha; Zhong, Bo; Lama, Rati; Su, Bin
COX inhibitors Indomethacin and Sulindac derivatives as antiproliferative agents: Synthesis, biological evaluation, and mechanism investigation
score: 2.1586182, European Journal of Medicinal Chemistry, 2012, Chennamaneni, Snigdha; Zhong, Bo; Lama, Rati; Su, Bin
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
score: 2.1584622, European Journal of Medicinal Chemistry, 2012, Wijtmans, Maikel et. al.
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
score: 2.1584622, European Journal of Medicinal Chemistry, 2012, Wijtmans, Maikel et. al.
Structurally diverse disaccharide analogs of antifreeze glycoproteins and their ability to inhibit ice recrystallization
score: 2.1574303, Bioorganic & Medicinal Chemistry Letters, 2012, Balcerzak, Anna K. et. al.
Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors
score: 2.1567964, Bioorganic & Medicinal Chemistry Letters, 2004, Tedder, Martina E. et. al.
Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU
score: 2.1561902, European Journal of Medicinal Chemistry, 2012, Min, Jun; Lin, Da; Zhang, Qingye; Zhang, Jibing; Yu, Ziniu
Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU
score: 2.1561902, European Journal of Medicinal Chemistry, 2012, Min, Jun; Lin, Da; Zhang, Qingye; Zhang, Jibing; Yu, Ziniu
Structure–activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents
score: 2.1552977, Bioorganic & Medicinal Chemistry, 2012, Mizuhara, Tsukasa et. al.
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization
score: 2.1552316, Bioorganic & Medicinal Chemistry, 2012, Prakasham, A.P. et. al.
Triarylpyrazoles with basic side chains
score: 2.1544412, Bioorganic & Medicinal Chemistry, 2001, Stauffer, Shaun R et. al.
Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors
score: 2.153565, Bioorganic & Medicinal Chemistry, 2005, Koshio, Hiroyuki et. al.
Discovery of a new class of potent, selective, and orally active prostaglandin D 2 receptor antagonists
score: 2.1535279, Bioorganic & Medicinal Chemistry, 2004, Torisu, Kazuhiko et. al.
Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues
score: 2.1532272, Bioorganic & Medicinal Chemistry, 2006, Bharate, Sandip B. et. al.
Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure–activity relationship
score: 2.1522914, Bioorganic & Medicinal Chemistry, 2002, Matter, Hans et. al.
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
score: 2.1520536, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics
score: 2.1517016, Bioorganic & Medicinal Chemistry Letters, 2012, Tran, Thanh-Dao et. al.
Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics
score: 2.1517016, Bioorganic & Medicinal Chemistry Letters, 2012, Tran, Thanh-Dao et. al.
Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity
score: 2.1500897, Bioorganic & Medicinal Chemistry, 2005, Mojarrad, Javid S. et. al.
Synthesis and Selective Cytotoxic Activity of Novel Hybrid Chalcones against Prostate Cancer Cells
score: 2.1494557, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Design and structure–activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization
score: 2.1486823, Bioorganic & Medicinal Chemistry, 2001, Zega, A et. al.
Cinnamic amides of ( S )-2-(aminomethyl)pyrrolidines are potent H 3 antagonists
score: 2.1483906, Bioorganic & Medicinal Chemistry, 2004, Peschke, Bernd et. al.
Structure-based 3D-QSAR studies on heteroarylpiperazine derivatives as 5-HT 3 receptor antagonists
score: 2.1483685, European Journal of Medicinal Chemistry, 2007, Zhou, Ya-Ju; Zhu, Li-Ping; Tang, Yun; Ye, De-Yong
Synthesis, antimycobacterial and antibacterial activity of ciprofloxacin derivatives containing a N-substituted benzyl moiety
score: 2.1479308, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Shuo et. al.
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin
score: 2.1478284, Bioorganic & Medicinal Chemistry, 1998, Anizon, Fabrice et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.1477554, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.1477554, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.1477554, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.1469299, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 2.14679, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 2.14679, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 2.14679, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Histone deacetylase inhibitors
score: 2.1466963, European Journal of Medicinal Chemistry, 2005, Monneret, Claude
Tetrabutylammonium fluoride-assisted rapid N 9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ
score: 2.1462184, Bioorganic & Medicinal Chemistry, 2005, Brik, Ashraf; Wu, Chung-Yi; Best, Michael D.; Wong, Chi-Huey
Inhibitory mode of 2-acetoxyphenyl alkyl sulfides against COX-1 and COX-2: QSAR analyses
score: 2.1458903, Bioorganic & Medicinal Chemistry Letters, 2006, Jain, Hemant Kumar; Mourya, V.K.; Agrawal, R.K.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 2.1454268, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 2.1454268, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
Systemic antibacterial activity of novel synthetic cyclic peptides.
score: 2.144389, Antimicrobial agents and chemotherapy, 2005, Dartois, Véronique et. al.
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step
score: 2.1442374, European Journal of Medicinal Chemistry, 2012, Ramunno, Anna et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition
score: 2.1438529, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)
score: 2.1436707, Bioorganic & Medicinal Chemistry, 1997, Dutta, A.K et. al.
Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)
score: 2.1436707, Bioorganic & Medicinal Chemistry, 1997, Dutta, A.K et. al.
Synthesis, receptor binding, and activation studies of N(1)-alkyl- l-histidine containing thyrotropin-releasing hormone (TRH) analogues
score: 2.1431694, Bioorganic & Medicinal Chemistry, 2006, Kaur, Navneet et. al.
Is chemical synthetic accessibility computationally predictable for drug and lead-like molecules? A comparative assessment between medicinal and computational chemists
score: 2.1429684, European Journal of Medicinal Chemistry, 2012, Bonnet, Pascal
Synthesis and biological activities of polyquinoline derivatives: New Bcl-2 family protein modulators
score: 2.1426848, European Journal of Medicinal Chemistry, 2012, Saugues, Emmanuelle et. al.
Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors
score: 2.1425738, Bioorganic & Medicinal Chemistry Letters, 2012, Jonckers, Tim H.M. et. al.
Development of α-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease
score: 2.1425271, Bioorganic & Medicinal Chemistry, 2005, Choe, Youngchool et. al.
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists
score: 2.1420936, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Structure requirements for anaerobe processing of azo compounds: Implications for prodrug design
score: 2.1417014, Bioorganic & Medicinal Chemistry Letters, 2012, Gavin, Jason et. al.
Toward the control of Leptosphaeria maculans: Design, syntheses, biological activity, and metabolism of potential detoxification inhibitors of the crucifer phytoalexin brassinin
score: 2.1409349, Bioorganic & Medicinal Chemistry, 2006, Pedras, M. Soledade C.; Jha, Mukund
Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: Dual inhibitors of EGFR and Src protein tyrosine kinases
score: 2.1407858, European Journal of Medicinal Chemistry, 2012, Lin, Jinsheng et. al.
Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents
score: 2.1402529, Bioorganic & Medicinal Chemistry, 2006, Sunduru, Naresh et. al.
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors
score: 2.140051, Bioorganic & Medicinal Chemistry, 2012, Alipour, Masoumeh et. al.
Synthesis of new sulfonamides as lipoxygenase inhibitors
score: 2.1400386, Bioorganic & Medicinal Chemistry, 2012, Mustafa, Ghulam et. al.
Design, synthesis, and structure–activity-relationship of phenyl imidazoles as potent Smoothened antagonists
score: 2.1400179, Bioorganic & Medicinal Chemistry Letters, 2012, Cheng, Dai et. al.
Design, synthesis, and structure–activity-relationship of phenyl imidazoles as potent Smoothened antagonists
score: 2.1400179, Bioorganic & Medicinal Chemistry Letters, 2012, Cheng, Dai et. al.
Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins
score: 2.1396619, Bioorganic & Medicinal Chemistry, 1998, Keenan, Terence et. al.
C 2-Symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases
score: 2.1395393, Bioorganic & Medicinal Chemistry, 1996, Qian, Xinhua et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1394266, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1394266, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1394266, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 2.1385025, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
score: 2.1384678, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Hermogenes N. et. al.
C-Glucosylated malonitrile as a key intermediate towards carbohydrate-based glycogen phosphorylase inhibitors
score: 2.1383706, Bioorganic & Medicinal Chemistry, 2012, Feuillastre, Sophie et. al.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives
score: 2.1382152, Bioorganic & Medicinal Chemistry, 2012, Hirose, Masaaki et. al.
Theoretical study of structure, p K a, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives
score: 2.1380492, Bioorganic & Medicinal Chemistry, 2006, Remko, Milan; Swart, Marcel; Bickelhaupt, F. Matthias
Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors
score: 2.1380337, Bioorganic & Medicinal Chemistry, 2005, Grunewald, Gary L. et. al.
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies
score: 2.1379144, Bioorganic & Medicinal Chemistry, 2013, Catarzi, Daniela et. al.
In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones
score: 2.1375284, Bioorganic & Medicinal Chemistry, 2004, Aguirre, Gabriela et. al.
QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR
score: 2.1370731, Bioorganic & Medicinal Chemistry, 2005, Zhu, Weiliang et. al.
Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety
score: 2.1360845, Bioorganic & Medicinal Chemistry Letters, 2012, Arai, Tadamasa et. al.
Synthesis and biological activity assays of some new N1-(flavon-7-yl) amidrazone derivatives and related congeners
score: 2.1358203, European Journal of Medicinal Chemistry, 2012, Abu-Aisheh, Marwa N. et. al.
Synthesis and Cytotoxicity of Lupane-Type Triterpenoid Glyceryl Esters
score: 2.1341882, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
New piperazinyl polyazacyclophane scaffolds, libraries and biological activities
score: 2.1337216, Bioorganic & Medicinal Chemistry Letters, 1998, An, Haoyun; Haly, Becky D.; Cook, P.Dan
5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents
score: 2.1331636, Bioorganic & Medicinal Chemistry, 2005, Ottanà, Rosaria et. al.
Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides
score: 2.1328549, Bioorganic & Medicinal Chemistry, 2004, Mitsch, Andreas et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 2.1328209, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 2.1328209, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 2.1328209, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents
score: 2.1327458, Bioorganic & Medicinal Chemistry Letters, 2012, Bandgar, Babasaheb P. et. al.
Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors
score: 2.1327297, European Journal of Medicinal Chemistry, 2004, Martić, Miljen et. al.
Three-dimensional quantitative structure–activity relationship studies on novel series of benzotriazine based compounds acting as Src inhibitors using CoMFA and CoMSIA
score: 2.1324816, Bioorganic & Medicinal Chemistry, 2008, Gueto, Carlos et. al.
Design and synthesis of broad-Based mono- and bi- cyclic inhibitors of FIV and HIV proteases
score: 2.132425, Bioorganic & Medicinal Chemistry, 2003, Mak, Chi Ching et. al.
Identification of pyrimidine derivatives as hSMG-1 inhibitors
score: 2.1323158, Bioorganic & Medicinal Chemistry Letters, 2012, Gopalsamy, Ariamala et. al.
Identification of pyrimidine derivatives as hSMG-1 inhibitors
score: 2.1323158, Bioorganic & Medicinal Chemistry Letters, 2012, Gopalsamy, Ariamala et. al.
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists
score: 2.1319668, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists
score: 2.1319668, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Synthesis, structure–activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors
score: 2.1311895, European Journal of Medicinal Chemistry, 2012, Ma, Xiao-Dong et. al.
Synthesis, structure–activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors
score: 2.1311895, European Journal of Medicinal Chemistry, 2012, Ma, Xiao-Dong et. al.
Synthesis, structure–activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors
score: 2.1311895, European Journal of Medicinal Chemistry, 2012, Ma, Xiao-Dong et. al.
Long-acting peptidomimetics based DPP-IV inhibitors
score: 2.1311805, Bioorganic & Medicinal Chemistry Letters, 2012, Jadav, Pradip et. al.
Long-acting peptidomimetics based DPP-IV inhibitors
score: 2.1311805, Bioorganic & Medicinal Chemistry Letters, 2012, Jadav, Pradip et. al.
GABA receptor antagonists and insecticides: common structural features of 4-alkyl-1-phenylpyrazoles and 4-alkyl-1-phenyltrioxabicyclooctanes
score: 2.130933, Bioorganic & Medicinal Chemistry, 2004, Sammelson, Robert E et. al.
Benzofuranones as potential antinociceptive agents: Structure–activity relationships
score: 2.1307705, European Journal of Medicinal Chemistry, 2012, Gonçalves, Cleiton José et. al.
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties
score: 2.1297591, European Journal of Medicinal Chemistry, 2002, Balsamo, Aldo et. al.
QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase
score: 2.1283263, Bioorganic & Medicinal Chemistry Letters, 2006, Jamloki, Ashutosh et. al.
Aryl Cyclopentadienyl Tricarbonyl Rhenium Complexes: Novel Ligands for the Estrogen Receptor with Potential Use as Estrogen Radiopharmaceuticals
score: 2.1281433, Bioorganic & Medicinal Chemistry, 2002, Mull, Eric S et. al.
Antibacterial activities of Groebke–Blackburn–Bienaymé-derived imidazo[1,2-a]pyridin-3-amines
score: 2.1274488, Bioorganic & Medicinal Chemistry, 2012, Shukla, Nikunj M. et. al.
Design, synthesis, and anti-integrase activity of catechol–DKA hybrids
score: 2.126661, Bioorganic & Medicinal Chemistry, 2006, Maurin, Cédric et. al.
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity
score: 2.1260434, Bioorganic & Medicinal Chemistry, 2013, Kwon, Yongseok et. al.
Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking
score: 2.1257892, Bioorganic & Medicinal Chemistry Letters, 2012, Fu, Jing et. al.
Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking
score: 2.1257892, Bioorganic & Medicinal Chemistry Letters, 2012, Fu, Jing et. al.
3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB 1 cannabinoid receptor
score: 2.1250191, Bioorganic & Medicinal Chemistry, 2003, Huffman, John W et. al.
Classification models for CYP450 3A4 inhibitors and non-inhibitors
score: 2.1244992, European Journal of Medicinal Chemistry, 2009, Choi, Inhee et. al.
Design, Prins-cyclization reaction promoting diastereoselective synthesis of 10 new tetrahydropyran derivatives and in vivo antinociceptive evaluations
score: 2.1240316, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Design, synthesis, and biological evaluation of ( E)- and ( Z)-styryl-2-acetoxyphenyl sulfides and sulfones as cyclooxygenase-2 inhibitors
score: 2.1238528, Bioorganic & Medicinal Chemistry, 2005, Reddy, M.V. Ramana et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase
score: 2.1236278, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase
score: 2.1236278, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase
score: 2.1236278, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
3D-QSAR Analysis of 2,4,5- and 2,3,4,5-substituted imidazoles as potent and nontoxic modulators of P-glycoprotein mediated MDR
score: 2.1235783, Bioorganic & Medicinal Chemistry, 2001, Kim, Ki H
Structure–activity relationships of a series of tariquidar analogs as multidrug resistance modulators
score: 2.1222638, Bioorganic & Medicinal Chemistry, 2006, Globisch, Christoph; Pajeva, Ilza K.; Wiese, Michael
Design, synthesis, and biological evaluation of substituted 3-alkylthio-4,5-diaryl-4 H-1,2,4-triazoles as selective COX-2 inhibitors
score: 2.1210272, Bioorganic & Medicinal Chemistry, 2006, Navidpour, Latifeh et. al.
Coumarin-trioxane hybrids: synthesis and evaluation as a new class of antimalarial scaffolds
score: 2.1208344, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells
score: 2.1207501, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells
score: 2.1207501, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells
score: 2.1207501, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors
score: 2.1206237, Bioorganic & Medicinal Chemistry, 2006, Khanna, Smriti et. al.
Tetraketones: A new class of tyrosinase inhibitors
score: 2.1205548, Bioorganic & Medicinal Chemistry, 2006, Khan, Khalid Mohammed et. al.
Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists
score: 2.119623, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Pyrrolo[2,1- d][1,2,3,5]tetrazine-4(3h)-ones, a new class of azolotetrazines with potent antitumor activity
score: 2.1195852, Bioorganic & Medicinal Chemistry, 2003, Diana, Patrizia et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines – σ1 receptor ligands with modified benzene-N-distance
score: 2.1195557, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
CoMFA and molecular docking studies of benzoxazoles and benzothiazoles as CYP450 1A1 inhibitors
score: 2.1193953, European Journal of Medicinal Chemistry, 2010, Pan, Jie et. al.
Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors
score: 2.1185182, Bioorganic & Medicinal Chemistry Letters, 2013, Yeung, Kap-Sun et. al.
3D-QSAR Study on Dihydro-1,3,5-triazines and Their Spiro Derivatives as DHFR Inhibitors by Comparative Molecular Field Analysis (CoMFA)
score: 2.1174951, Bioorganic & Medicinal Chemistry Letters, 2012, Ma, Xiang; Xiang, Guangya; Yap, Chun-Wei; Chui, Wai-Keung
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.1168755, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.1168755, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.1168755, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives
score: 2.1164371, Bioorganic & Medicinal Chemistry, 2005, Imamura, Shinichi et. al.
Derivatives of 8-hydroxyquinoline – antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.1155147, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Synthesis and biological evaluation of 2,7-Dihydro-3 H-dibenzo[ de, h]cinnoline-3,7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line
score: 2.1153701, Bioorganic & Medicinal Chemistry, 2003, Stefańska, Barbara et. al.
Design and synthesis of potent, isoxazole-containing renin inhibitors
score: 2.1148571, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier, Pierre-André et. al.
Design and synthesis of potent, isoxazole-containing renin inhibitors
score: 2.1148571, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier, Pierre-André et. al.
Synthesis and evaluation of antitubercular activity of imidazo[2,1- b][1,3,4]thiadiazole derivatives
score: 2.1146284, Bioorganic & Medicinal Chemistry, 2006, Kolavi, Gundurao et. al.
A synthetic route to a novel type of conformationally constrained N-aryloxazolidinones
score: 2.1143364, Bioorganic & Medicinal Chemistry Letters, 2005, Griera, Rosa et. al.
A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation
score: 2.1142197, Bioorganic & Medicinal Chemistry Letters, 2012, Graham, Thomas H. et. al.
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
score: 2.1142099, Bioorganic & Medicinal Chemistry, 2012, Peng, Da-Yong et. al.
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
score: 2.1142099, Bioorganic & Medicinal Chemistry, 2012, Peng, Da-Yong et. al.
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
score: 2.1142099, Bioorganic & Medicinal Chemistry, 2012, Peng, Da-Yong et. al.
Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: Synthesis and toxicity for drug-resistant tumor cells
score: 2.1141548, Bioorganic & Medicinal Chemistry, 2006, Ol’shevskaya, Valentina A. et. al.
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
score: 2.1136027, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
score: 2.1136027, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
score: 2.1136027, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression
score: 2.1134258, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Jiho et. al.
Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression
score: 2.1134258, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Jiho et. al.
Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression
score: 2.1134258, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Jiho et. al.
Novel Potent 5-HT 3 Receptor Ligands Based on the Pyrrolidone Structure: Synthesis, Biological Evaluation, and Computational Rationalization of the Ligand–Receptor Interaction Modalities
score: 2.113129, Bioorganic & Medicinal Chemistry, 2002, Cappelli, Andrea et. al.
Synthesis and protein kinase C inhibitory activities of balanol analogues with modification of 4-hydroxybenzamido moiety
score: 2.1128213, Bioorganic & Medicinal Chemistry, 1997, Hu, Hong et. al.
8,9-Dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,- de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms
score: 2.1119504, Bioorganic & Medicinal Chemistry, 2004, Grubbs, Russell A et. al.
Synthesis and cytotoxic evaluation of certain 4-anilino-2-phenylquinoline derivatives
score: 2.1119355, European Journal of Medicinal Chemistry, 2005, Zhao, Yue-Ling et. al.
Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor
score: 2.1119146, Bioorganic & Medicinal Chemistry Letters, 2004, Tan, Christopher et. al.
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
score: 2.1118643, Bioorganic & Medicinal Chemistry Letters, 2012, Balboni, Gianfranco et. al.
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
score: 2.1118643, Bioorganic & Medicinal Chemistry Letters, 2012, Balboni, Gianfranco et. al.
C-6 Aryl Substituted 4-Quinolone-3-carboxylic Acids as Inhibitors of Hepatitis C Virus
score: 2.1117577, Bioorganic & Medicinal Chemistry, 2012, Chen, Yue-Lei et. al.
C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus
score: 2.1117577, Bioorganic & Medicinal Chemistry, 2012, Chen, Yue-Lei et. al.
C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus
score: 2.1117577, Bioorganic & Medicinal Chemistry, 2012, Chen, Yue-Lei et. al.
Recent results in protein kinase inhibition for tropical diseases
score: 2.1116432, Bioorganic & Medicinal Chemistry Letters, 2012, Rotella, David P.
Recent results in protein kinase inhibition for tropical diseases
score: 2.1116432, Bioorganic & Medicinal Chemistry Letters, 2012, Rotella, David P.
Recent results in protein kinase inhibition for tropical diseases
score: 2.1116432, Bioorganic & Medicinal Chemistry Letters, 2012, Rotella, David P.
3-(N-Arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2)
score: 2.110579, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Soo Hyuk et. al.
Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine
score: 2.1095632, Bioorganic & Medicinal Chemistry, 2006, Zhang, Shijun et. al.
Non-thiol farnesyltransferase inhibitors: n-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides
score: 2.1086586, Bioorganic & Medicinal Chemistry, 2003, Kettler, Katja et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.1080257, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Long-acting Peptidomimetics based DPP-IV Inhibitors
score: 2.1067045, Bioorganic & Medicinal Chemistry Letters, 2012, Jadav, Pradip et. al.
3D-QSAR analysis of human immunodeficiency virus entry-1 inhibitors by CoMFA and CoMSIA
score: 2.1063486, European Journal of Medicinal Chemistry, 2010, Pirhadi, Somayeh; Ghasemi, Jahan B.
Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase
score: 2.1062017, Bioorganic & Medicinal Chemistry, 2006, Charvat, Trevor T. et. al.
3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists
score: 2.1056244, Bioorganic & Medicinal Chemistry Letters, 2007, Zhang, Tao et. al.
Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella.
score: 2.105592, Antimicrobial agents and chemotherapy, 2012, Schaeffer, Marie et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.1048989, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
A novel series ofN-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists
score: 2.104757, Bioorganic & Medicinal Chemistry Letters, 2013, Subasinghe, Nalin L. et. al.
Discovery of a novel series of 4-quinolone JNK inhibitors
score: 2.104713, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Discovery of a novel series of 4-quinolone JNK inhibitors
score: 2.104713, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Discovery of a novel series of 4-quinolone JNK inhibitors
score: 2.104713, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting α vβ 3/α IIbβ 3 dual antagonistic activity
score: 2.104346, Bioorganic & Medicinal Chemistry, 2006, Kubota, Dai et. al.
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
score: 2.1042564, Bioorganic & Medicinal Chemistry Letters, 2012, Balboni, Gianfranco et. al.
Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Aβ 25–35 in PC12 cells
score: 2.1042273, Bioorganic & Medicinal Chemistry Letters, 2009, Lee, Sang-Hoon et. al.
Synthesis, characterization and structure optimization of a series of thiazolidinone derivatives as Entamoeba histolytica inhibitors
score: 2.1042082, European Journal of Medicinal Chemistry, 2012, Mushtaque, Md.; Avecilla, Fernando; Azam, Amir
Synthesis and Biological Evaluation of New Piplartine Analogues as Potent Aldose Reductase Inhibitors (ARIs)
score: 2.1036769, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Contribution to Investigation of Antimicrobial Activity of Styrylquinolines
score: 2.1026244, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Synthesis and biological evaluation of 2-thiopyrimidine derivatives
score: 2.102409, Bioorganic & Medicinal Chemistry, 2005, Sondhi, Sham M. et. al.
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
score: 2.1016817, Bioorganic & Medicinal Chemistry Letters, 2012, Youngsaye, Willmen et. al.
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
score: 2.1016817, Bioorganic & Medicinal Chemistry Letters, 2012, Youngsaye, Willmen et. al.
Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5′-sulfonamide moiety of a phenyl ring
score: 2.1009597, Bioorganic & Medicinal Chemistry, 2001, Kim, Dae-Kee et. al.
Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors
score: 2.1008763, Bioorganic & Medicinal Chemistry, 2006, Mannino, Claudia et. al.
Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides
score: 2.1005189, Bioorganic & Medicinal Chemistry, 2003, Larsson, Andreas et. al.
A novel series of pyrazolylpiperidine N-type calcium channel blockers
score: 2.1002906, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
A novel series of pyrazolylpiperidine N-type calcium channel blockers
score: 2.1002906, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
A novel series of pyrazolylpiperidine N-type calcium channel blockers
score: 2.1002906, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
score: 2.1001974, Antimicrobial agents and chemotherapy, 2011, Mills, Scott D et. al.
Pharmacophore identification of c-Myc inhibitor 10074-G5
score: 2.1000488, Bioorganic & Medicinal Chemistry Letters, 2013, Yap, Jeremy L. et. al.
2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors
score: 2.1000292, Bioorganic & Medicinal Chemistry Letters, 2012, Hua, Zihao et. al.
Indole and benzimidazole derivatives as steroid 5α-reductase inhibitors in the rat prostate
score: 2.0999117, Bioorganic & Medicinal Chemistry, 1998, Takami, Hitoshi et. al.
3D-QSAR CoMFA and CoMSIA on protein tyrosine phosphatase 1B inhibitors
score: 2.0996768, Bioorganic & Medicinal Chemistry, 2002, Murthy, V.Sreenivasa; Kulkarni, Vithal M
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 2.0996326, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0994603, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0994603, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0994603, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase
score: 2.0993737, Bioorganic & Medicinal Chemistry, 2003, Pez, Didier et. al.
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
score: 2.0986613, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
score: 2.0986613, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
Chemotherapy of leishmaniasis. Part XI: Synthesis and bioevaluation of novel isoxazole containing heteroretinoid and its amide derivatives
score: 2.0981975, Bioorganic & Medicinal Chemistry Letters, 2012, Suryawanshi, S.N. et. al.
Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives
score: 2.0980283, Bioorganic & Medicinal Chemistry Letters, 2012, Matsumoto, Kohji et. al.
An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
score: 2.09765, Bioorganic & Medicinal Chemistry, 2012, Verbanac, Donatella et. al.
An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
score: 2.09765, Bioorganic & Medicinal Chemistry, 2012, Verbanac, Donatella et. al.
Derivatives of 8-hydroxyquinoline—antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.0973415, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Derivatives of 8-hydroxyquinoline—antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.0973415, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Derivatives of 8-hydroxyquinoline—antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.0973415, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1
score: 2.097217, Bioorganic & Medicinal Chemistry Letters, 2012, Gemma, Sandra et. al.
Synthesis and antimuscarinic activity of a Series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents
score: 2.0968381, Bioorganic & Medicinal Chemistry, 1999, Miyachi, Hiroyuki et. al.
New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells
score: 2.0967908, European Journal of Medicinal Chemistry, 2012, Ottanà, Rosaria et. al.
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
score: 2.0958417, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
score: 2.0958417, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
score: 2.0958417, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives
score: 2.0952832, European Journal of Medicinal Chemistry, 2012, Awadallah, Fadi M.; El-Eraky, Wafaa I.; Saleh, Dalia O.
Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives
score: 2.0952832, European Journal of Medicinal Chemistry, 2012, Awadallah, Fadi M.; El-Eraky, Wafaa I.; Saleh, Dalia O.
Anti-inflammatory profile of some synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure
score: 2.095267, Bioorganic & Medicinal Chemistry, 2006, Amr, Abdel-Galil E.; Abdulla, Mohamed M.
Functionalized amido ketones: new anticonvulsant agents
score: 2.0952561, Bioorganic & Medicinal Chemistry, 2003, Béguin, Cécile et. al.
Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABA B receptor affinities
score: 2.0944773, Bioorganic & Medicinal Chemistry Letters, 1998, Carruthers, Nicholas I. et. al.
Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole analogues of duocarmycin B2
score: 2.0942719, Bioorganic & Medicinal Chemistry, 1996, Nagamura, Satoru et. al.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 2.0940914, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group
score: 2.0938996, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Guanglin et. al.
Carbonic anhydrase inhibitors
score: 2.0935175, Bioorganic & Medicinal Chemistry Letters, 2010, Supuran, Claudiu T.
Development of bestatin-based activity-based probes for metallo-aminopeptidases
score: 2.092986, Bioorganic & Medicinal Chemistry Letters, 2008, Harbut, Michael B. et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.0926567, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
score: 2.0920298, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Li-Jun et. al.
Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation
score: 2.0918491, Bioorganic & Medicinal Chemistry, 2012, Yan, Jin-Wu et. al.
Synthesis and antibacterial activity against Clostridium difficile of novel demethylvancomycin derivatives
score: 2.0917324, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Si-Ji; Yang, Qing; Xu, Liang; Chang, Jun; Sun, Xun
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0912441, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists
score: 2.0904366, Bioorganic & Medicinal Chemistry, 2012, Hanson, Robert N. et. al.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 2.089574, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors
score: 2.0892872, Bioorganic & Medicinal Chemistry, 2003, Kim, Su Yeon; Lee, Jeewoo
Design, synthesis, and evaluation of novel galloyl pyrrolidine derivatives as potential anti-tumor agents
score: 2.0885759, Bioorganic & Medicinal Chemistry, 2006, Li, Xun; Li, Yalin; Xu, Wenfang
Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3- b]pyridine derivatives
score: 2.0884687, Bioorganic & Medicinal Chemistry, 2006, Rolim Bernardino, Alice Maria et. al.
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
score: 2.0876381, Bioorganic & Medicinal Chemistry Letters, 2012, McAllister, Laura A. et. al.
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
score: 2.0876381, Bioorganic & Medicinal Chemistry Letters, 2012, McAllister, Laura A. et. al.
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
score: 2.0876381, Bioorganic & Medicinal Chemistry Letters, 2012, McAllister, Laura A. et. al.
Structural studies of [2′,6′-dimethyl- l-tyrosine 1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond
score: 2.0867902, Bioorganic & Medicinal Chemistry, 2003, Okada, Yoshio et. al.
The development of 3D-QSAR study and recursive partitioning of heterocyclic quinone derivatives with antifungal activity
score: 2.0863989, Bioorganic & Medicinal Chemistry, 2006, Choi, Su-Young et. al.
In vitro evaluation of the anti-estrogenic activity of hydroxyl substituted diphenylnaphthyl alkene ligands for the estrogen receptor
score: 2.0862984, Bioorganic & Medicinal Chemistry, 2005, Schmidt, Jonathan M. et. al.
2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A 2A receptor
score: 2.0862643, Bioorganic & Medicinal Chemistry, 2003, van Tilburg, Erica W et. al.
N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor
score: 2.0861708, Bioorganic & Medicinal Chemistry Letters, 2012, Vallin, Karl S.A. et. al.
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer’s disease
score: 2.0853459, Bioorganic & Medicinal Chemistry, 2012, Roy, Kuldeep K. et. al.
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer’s disease
score: 2.0853459, Bioorganic & Medicinal Chemistry, 2012, Roy, Kuldeep K. et. al.
A combined approach of docking and 3D QSAR study of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 2.0834107, Bioorganic & Medicinal Chemistry, 2006, Ashek, Ali; Cho, Seung Joo
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.0828195, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles
score: 2.0825521, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yuusuke et. al.
Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis
score: 2.081599, Bioorganic & Medicinal Chemistry, 2006, Poulsen, Sally-Ann; Bornaghi, Laurent F.
3D-QSAR of N-myristoyltransferase inhibiting antifungal agents by CoMFA and CoMSIA methods
score: 2.0811661, Bioorganic & Medicinal Chemistry, 2003, Purushottamachar, P.; Kulkarni, Vithal M.
Synthesis, biological evaluation and structure–activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
score: 2.0811621, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Li-Jun et. al.
Synthesis, biological evaluation and structure–activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
score: 2.0811621, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Li-Jun et. al.
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
score: 2.0811344, Bioorganic & Medicinal Chemistry, 2012, Mao, Weiwei et. al.
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
score: 2.0811344, Bioorganic & Medicinal Chemistry, 2012, Mao, Weiwei et. al.
3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists
score: 2.0811232, Bioorganic & Medicinal Chemistry, 2004, Mitchell, Daniel D et. al.
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics
score: 2.08112, European Journal of Medicinal Chemistry, 2012, Sarkar, Aurijit; Anderson, Kelcey C.; Kellogg, Glen E.
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics
score: 2.08112, European Journal of Medicinal Chemistry, 2012, Sarkar, Aurijit; Anderson, Kelcey C.; Kellogg, Glen E.
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics
score: 2.08112, European Journal of Medicinal Chemistry, 2012, Sarkar, Aurijit; Anderson, Kelcey C.; Kellogg, Glen E.
Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties
score: 2.0810451, Bioorganic & Medicinal Chemistry, 2012, Rakesh, et. al.
Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones
score: 2.0808374, Bioorganic & Medicinal Chemistry Letters, 2012, Ochiai, Koji et. al.
Structure requirements for anaerobe processing of azo compounds: Implications for prodrug design
score: 2.0802787, Bioorganic & Medicinal Chemistry Letters, 2012, Gavin, Jason et. al.
Structure requirements for anaerobe processing of azo compounds: Implications for prodrug design
score: 2.0802787, Bioorganic & Medicinal Chemistry Letters, 2012, Gavin, Jason et. al.
Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues
score: 2.0798219, Bioorganic & Medicinal Chemistry, 2013, Bhabak, Krishna P. et. al.
C(8)-Substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands
score: 2.0796281, Bioorganic & Medicinal Chemistry, 2004, Goo Kim, Myoung et. al.
Design of novel nicotinic ligands through 3D database searching
score: 2.0792665, Bioorganic & Medicinal Chemistry, 2005, Guandalini, Luca et. al.
Structural analogues of 5-OMe-BPAT: synthesis and interactions with dopamine D 2, D 3, and serotonin 5-HT 1A receptors
score: 2.0789897, Bioorganic & Medicinal Chemistry, 1999, Homan, Evert J. et. al.
Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity
score: 2.0783777, Bioorganic & Medicinal Chemistry, 2003, Clarkson, Cailean et. al.
3D-QSAR studies of indole derivatives as phosphodiesterase IV inhibitors
score: 2.0781624, European Journal of Medicinal Chemistry, 2003, Chakraborti, Asit K et. al.
Pyrazole-based arylalkyne Cathepsin S inhibitors. Part III: Modification of P4 region
score: 2.0781279, Bioorganic & Medicinal Chemistry Letters, 2013, Wiener, John J.M. et. al.
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
score: 2.0780141, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
score: 2.0780141, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
score: 2.0780141, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity
score: 2.0777275, Bioorganic & Medicinal Chemistry Letters, 2012, Jakopović, Ivana Palej et. al.
Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity
score: 2.0777275, Bioorganic & Medicinal Chemistry Letters, 2012, Jakopović, Ivana Palej et. al.
Biotin-phenyldiazomethane conjugates as labeling reagents at phosphate in mono and polynucleotides
score: 2.0776134, Bioorganic & Medicinal Chemistry, 2005, Bourget, Cécile et. al.
Design and synthesis of 2-acetamidomethyl derivatives of isofagomine as potential inhibitors of human lysosomal β-hexosaminidases
score: 2.0772661, Bioorganic & Medicinal Chemistry, 2004, van den Berg, Richard J.B.H.N et. al.
Synthesis and antitumor activity of duocarmycin derivatives: modification at C-8 position of A-ring pyrrole compounds bearing the simplified DNA-binding groups
score: 2.0767512, Bioorganic & Medicinal Chemistry, 2000, Amishiro, Nobuyoshi et. al.
Structure–activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter
score: 2.0760973, Bioorganic & Medicinal Chemistry, 2006, Boos, Terrence L. et. al.
Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR
score: 2.0760019, Bioorganic & Medicinal Chemistry Letters, 2010, Mitchell, Charlotte J. et. al.
TAK-599, a novel N-Phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties
score: 2.0753744, Bioorganic & Medicinal Chemistry, 2003, Ishikawa, Tomoyasu et. al.
Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors
score: 2.074789, Bioorganic & Medicinal Chemistry Letters, 2012, Sun, Lian-Qi et. al.
Synthesis and glycosidase inhibitory activities of 2-(aminoalkyl)pyrrolidine-3,4-diol derivatives
score: 2.0747539, Bioorganic & Medicinal Chemistry, 2003, Carmona, Ana T et. al.
Identification and characterization of new inhibitors of the Escherichia coli MurA enzyme.
score: 2.0743389, Antimicrobial agents and chemotherapy, 2001, Baum, E Z et. al.
Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor
score: 2.0742457, Bioorganic & Medicinal Chemistry, 2012, Wang, Fang et. al.
Synthesis, characterization and antibacterial activities of some new ferrocene-containing penems
score: 2.0734394, European Journal of Medicinal Chemistry, 2010, Long, Bohua; He, Chunlian; Yang, Yingbin; Xiang, Jiannan
Development and assessment of a 3D pharmacophore for ligand recognition of BDZR/GABA A receptors initiating the anxiolytic response
score: 2.0733608, Bioorganic & Medicinal Chemistry, 2000, Harris, Danni L; Loew, Gilda
Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application
score: 2.0729243, Bioorganic & Medicinal Chemistry Letters, 2013, Kesteleyn, Bart et. al.
Synthesis and Antimalarial Activity of Calothrixins A and B, and their N-Alkyl Derivatives
score: 2.0724927, Bioorganic & Medicinal Chemistry Letters, 2012, Matsumoto, Kohji et. al.
Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives
score: 2.0723856, Bioorganic & Medicinal Chemistry Letters, 2012, Matsumoto, Kohji et. al.
Design, Prins–Cyclization Reaction Promoting Diastereoselective Synthesis of Ten New Tetrahydropyran Derivatives and in vivo Antinociceptive Evaluations
score: 2.072277, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
score: 2.0715312, Bioorganic & Medicinal Chemistry, 2012, Yoshida, Tomohiro et. al.
Synthesis and anticancer activity of a series of norcantharidin analogues
score: 2.0712728, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety
score: 2.0712482, European Journal of Medicinal Chemistry, 2012, Metwally, M.A.; Gouda, M.A.; Harmal, Ammar N.; Khalil, A.M.
Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety
score: 2.0712482, European Journal of Medicinal Chemistry, 2012, Metwally, M.A.; Gouda, M.A.; Harmal, Ammar N.; Khalil, A.M.
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
score: 2.0707587, Bioorganic & Medicinal Chemistry, 2006, Dong, Yuxiang et. al.
Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5 H-benzo[5,6]-cyclohepta[1,2- b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase
score: 2.0698018, Bioorganic & Medicinal Chemistry, 1999, Afonso, Adriano et. al.
Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers
score: 2.0694228, Bioorganic & Medicinal Chemistry Letters, 2002, Olsen, J.A et. al.
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings
score: 2.0693824, Bioorganic & Medicinal Chemistry, 2006, Deng, Bo-Liang et. al.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
score: 2.0687702, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel J. et. al.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
score: 2.0687702, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel J. et. al.
Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity
score: 2.0681991, Nature chemical biology, 2010, Bruning, John B. et. al.
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents
score: 2.0681272, European Journal of Medicinal Chemistry, 2012, Tonk, Rajiv Kumar et. al.
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
score: 2.0680923, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
score: 2.0675494, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
score: 2.0675494, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
Boronic acids as inhibitors of steroid sulfatase
score: 2.067072, Bioorganic & Medicinal Chemistry, 2006, Ahmed, Vanessa et. al.
Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2
score: 2.0669844, Bioorganic & Medicinal Chemistry Letters, 2012, Tynebor, Robert M. et. al.
In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers
score: 2.0669742, Bioorganic & Medicinal Chemistry, 2003, Vargas M, Leonor Y et. al.
Synthesis, biological evaluation, and structural studies on N1 and C5 substituted cycloalkyl analogues of the pyrazole class of CB1 and CB2 ligands
score: 2.0666896, Bioorganic & Medicinal Chemistry, 2004, Krishnamurthy, Mathangi; Li, Wei; Moore, Bob M
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases
score: 2.0663639, Bioorganic & Medicinal Chemistry, 2013, Lai, Huiguo et. al.
Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems—I. 2-alkoxymethyl derivatives
score: 2.0663057, Bioorganic & Medicinal Chemistry, 1997, Azami, Hidenori et. al.
Synthesis and structure–activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT)
score: 2.0662088, Bioorganic & Medicinal Chemistry Letters, 2004, Ohnuma, Satoshi et. al.
Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone
score: 2.0661025, Bioorganic & Medicinal Chemistry, 2005, Cao, Shugeng et. al.
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
score: 2.0659933, Bioorganic & Medicinal Chemistry, 2012, B-Rao, Chandrika et. al.
Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty
score: 2.065804, Bioorganic & Medicinal Chemistry Letters, 2012, Basarab, Gregory S. et. al.
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies
score: 2.0656084, European Journal of Medicinal Chemistry, 2012, Ceras, Javier et. al.
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies
score: 2.0656084, European Journal of Medicinal Chemistry, 2012, Ceras, Javier et. al.
Design and synthesis of highly constrained factor Xa inhibitors: amidine-Substituted bis(benzoyl)- [1,3]-diazepan-2-ones and bis(benzylidene)-bis( gem-dimethyl)cycloketones
score: 2.0655916, Bioorganic & Medicinal Chemistry, 2003, Cui, Jian et. al.
Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β
score: 2.0655101, Bioorganic & Medicinal Chemistry, 2003, Minutolo, Filippo et. al.
Design, synthesis and biological activities of sorafenib derivatives as antitumor agents
score: 2.0653084, Bioorganic & Medicinal Chemistry Letters, 2012, Yao, Jianwen et. al.
Design, synthesis and biological activities of sorafenib derivatives as antitumor agents
score: 2.0653084, Bioorganic & Medicinal Chemistry Letters, 2012, Yao, Jianwen et. al.
Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation
score: 2.0652963, Bioorganic & Medicinal Chemistry Letters, 2012, Ongarora, Dennis S.B. et. al.
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0641546, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides
score: 2.0639359, Bioorganic & Medicinal Chemistry, 2012, Nauš, Petr et. al.
3D-QSAR analysis of conformationally constrained diacylglycerol (DAG) analogues as potent protein kinase C (PK-C) ligands
score: 2.0638287, Bioorganic & Medicinal Chemistry, 2004, Kim, Su Yeon; Lee, Jeewoo
Parallel liquid synthesis of N, N′-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors
score: 2.0634176, Bioorganic & Medicinal Chemistry, 2003, Le Diguarher, Thierry et. al.
New potent cathepsin G phosphonate inhibitors
score: 2.0634102, Bioorganic & Medicinal Chemistry, 2008, Sieńczyk, Marcin et. al.
Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y 1 receptor antagonists
score: 2.0628355, Bioorganic & Medicinal Chemistry, 2004, Mathieu, Romain et. al.
Regiospecific one-pot synthesis of pyrimido[4,5- d]pyrimidine derivatives in the solid state under microwave irradiations
score: 2.062659, Bioorganic & Medicinal Chemistry Letters, 2006, Prajapati, Dipak; Gohain, Mukut; Thakur, Ashim J.
Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4
score: 2.0622363, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Renren et. al.
Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library
score: 2.062213, Bioorganic & Medicinal Chemistry, 2005, Sagi, Kazuyuki et. al.
A model for identifying HERG K + channel blockers
score: 2.0617439, Bioorganic & Medicinal Chemistry, 2004, Aronov, Alex M.; Goldman, Brian B.
Synthesis and SAR studies of bicyclic amine series GPR119 agonists
score: 2.0614995, Bioorganic & Medicinal Chemistry Letters, 2012, Sakairi, Masao et. al.
[( S)-γ-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
score: 2.060685, Bioorganic & Medicinal Chemistry, 2006, Sakashita, Hiroshi et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycles leading to the discovery of TMC647055
score: 2.0605383, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists
score: 2.0605276, Bioorganic & Medicinal Chemistry Letters, 2012, Davies, David J. et. al.
Pyrazolopyridine inhibitors of B-RafV600E. Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors
score: 2.0603449, Bioorganic & Medicinal Chemistry Letters, 2012, Wenglowsky, Steve et. al.
Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure–activity relationships
score: 2.0603362, Bioorganic & Medicinal Chemistry Letters, 2012, Reid, Carolyn S. et. al.
Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure–activity relationships
score: 2.0603362, Bioorganic & Medicinal Chemistry Letters, 2012, Reid, Carolyn S. et. al.
Synthesis of [19, 35, 36- 13C 3]-labeled TAK779 as a molecular probe
score: 2.0602185, Bioorganic & Medicinal Chemistry, 2009, Konno, Hiroyuki et. al.
Antileishmanial Bis-arylimidamides: DB766 Analogs Modified in the Linker Region and Bis-arylimidamide Structure-activity Relationships
score: 2.0600286, Bioorganic & Medicinal Chemistry Letters, 2012, Reid, Carolyn S. et. al.
Synthesis, Biological Evaluation and Molecular Docking Studies of 3-(Triazolyl)-coumarin Derivatives: Effect on Inducible Nitric Oxide Synthase
score: 2.059357, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3- d]pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors
score: 2.0589361, Bioorganic & Medicinal Chemistry, 2005, Matulenko, Mark A. et. al.
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors
score: 2.0584543, Bioorganic & Medicinal Chemistry, 2012, Alipour, Masoumeh et. al.
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors
score: 2.0584543, Bioorganic & Medicinal Chemistry, 2012, Alipour, Masoumeh et. al.
Molecular docking and 3D-QSAR studies of Yersinia protein tyrosine phosphatase YopH inhibitors
score: 2.0580259, Bioorganic & Medicinal Chemistry, 2005, Hu, Xin; Erec Stebbins, C.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
score: 2.0577575, European Journal of Medicinal Chemistry, 2012, Menendez, Christophe et. al.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
score: 2.0577575, European Journal of Medicinal Chemistry, 2012, Menendez, Christophe et. al.
1,4-Dihydro-2,3-quinoxalinediones as potential flavin metabolites and excitatory amino acid receptor ligands. Part 1: Synthesis and pharmacological evaluation of the benzylic oxidation series of 1,4-dihydro-6,7-dimethyl-2,3-quinoxalinedione
score: 2.0575183, Bioorganic & Medicinal Chemistry, 1998, Bhat, Ajita et. al.
Pyridonepezils, New Dual AChE inhibitors as Potential Drugs for the Treatment of Alzheimer’s Disease: Synthesis, Biological Assessment, and Molecular Modeling
score: 2.0574629, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators
score: 2.0573872, Bioorganic & Medicinal Chemistry, 2006, Avila, Carolina Martins et. al.
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: Docking-based CoMFA and CoMSIA analyses
score: 2.0570584, European Journal of Medicinal Chemistry, 2009, Cichero, Elena et. al.
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides
score: 2.0565391, Bioorganic & Medicinal Chemistry, 2006, George, Tesmol G. et. al.
6-Substituted 6 H-dibenzo[ c, h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity
score: 2.0564867, Bioorganic & Medicinal Chemistry, 2006, Zhu, Shejin et. al.
Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners
score: 2.0563146, European Journal of Medicinal Chemistry, 2012, Abu-Aisheh, Marwa N. et. al.
Triazoloamides as Potent γ-Secretase Modulators with Reduced hERG Liability
score: 2.0562768, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Isoquinoline derivatives as potent CRTH2 receptor antagonists: Synthesis and SAR
score: 2.056176, Bioorganic & Medicinal Chemistry Letters, 2012, Nishikawa-Shimono, Rie et. al.
Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors
score: 2.0561399, Bioorganic & Medicinal Chemistry, 2012, Lawrence Woo, L.W. et. al.
Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors
score: 2.0561399, Bioorganic & Medicinal Chemistry, 2012, Lawrence Woo, L.W. et. al.
Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol
score: 2.055498, Bioorganic & Medicinal Chemistry, 2006, Bernardes, Lilian Sibelle Campos et. al.
Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase
score: 2.0554532, Bioorganic & Medicinal Chemistry Letters, 2012, Heasley, Brian H. et. al.
Synthesis ofN4-(substituted phenyl)-N4-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells
score: 2.0551744, Bioorganic & Medicinal Chemistry, 2013, Gangjee, Aleem et. al.
Comparative molecular field analysis of non-steroidal aromatase inhibitors: an extended model for two different structural classes
score: 2.0551515, Bioorganic & Medicinal Chemistry, 1998, Recanatini, Maurizio; Cavalli, Andrea
Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti- Mycobacterium activity
score: 2.0547322, Bioorganic & Medicinal Chemistry, 2006, Kamal, Ahmed et. al.
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors
score: 2.0546564, Bioorganic & Medicinal Chemistry Letters, 2012, Radi, Marco et. al.
Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine
score: 2.0546131, Bioorganic & Medicinal Chemistry, 2004, Wamberg, Michael et. al.
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3- d]pyrimidine series
score: 2.0541959, Bioorganic & Medicinal Chemistry, 2005, Amblard, Franck et. al.
Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia
score: 2.0541015, Bioorganic & Medicinal Chemistry Letters, 2012, Cutshall, Neil S. et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines –σ1 receptor ligands with modified benzene-N-distance
score: 2.0537998, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy
score: 2.0537857, Bioorganic & Medicinal Chemistry Letters, 2012, Liddle, John et. al.
Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells
score: 2.0535994, Bioorganic & Medicinal Chemistry, 2012, Barcelos, Rosimeire Coura et. al.
Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells
score: 2.0535994, Bioorganic & Medicinal Chemistry, 2012, Barcelos, Rosimeire Coura et. al.
Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells
score: 2.0535994, Bioorganic & Medicinal Chemistry, 2012, Barcelos, Rosimeire Coura et. al.
Synthesis and biological activities of new 1α,25-dihydroxy-19-norvitamin D 3 analogs with modifications in both the A-ring and the side chain
score: 2.0533643, Bioorganic & Medicinal Chemistry, 2006, Shimizu, Masato et. al.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0527043, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0527043, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0527043, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore
score: 2.0526356, Bioorganic & Medicinal Chemistry, 2006, Nguyen, Tam Luong et. al.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0522838, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s
score: 2.0520733, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s
score: 2.0520733, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s
score: 2.0520733, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.0515738, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.0515738, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters
score: 2.0511685, Bioorganic & Medicinal Chemistry, 2004, Zhang, Shijun et. al.
Synthesis and structure–activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors
score: 2.0511374, Bioorganic & Medicinal Chemistry Letters, 2012, Kumar, Arun Babu et. al.
Synthesis and structure–activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors
score: 2.0511374, Bioorganic & Medicinal Chemistry Letters, 2012, Kumar, Arun Babu et. al.
A new structural alternative in benzo[ b]furans for antimicrobial activity
score: 2.0510489, Bioorganic & Medicinal Chemistry, 2005, Wahab Khan, M. et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus Kinase 2 (JAK2) inhibitors
score: 2.0509339, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
Stochastic entropy QSAR for the in silico discovery of anticancer compounds: Prediction, synthesis, and in vitro assay of new purine carbanucleosides
score: 2.0507758, Bioorganic & Medicinal Chemistry, 2006, González-Díaz, Humberto et. al.
Short synthesis and antimalarial activity of fagaronine
score: 2.0506444, Bioorganic & Medicinal Chemistry, 2012, Rivaud, M. et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 2.0504432, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 2.0504432, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors
score: 2.0504305, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ligong et. al.
Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors
score: 2.050405, Bioorganic & Medicinal Chemistry Letters, 2013, Pecic, Stevan et. al.
Unified QSAR approach to antimicrobials. Part 2: Predicting activity against more than 90 different species in order to halt antibacterial resistance
score: 2.049957, Bioorganic & Medicinal Chemistry, 2007, Prado-Prado, Francisco J. et. al.
Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators
score: 2.0499348, Bioorganic & Medicinal Chemistry Letters, 2012, Packiarajan, Mathivanan et. al.
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors
score: 2.0499077, Bioorganic & Medicinal Chemistry, 2006, Soper, David L. et. al.
Sulfonilamidothiopyrimidone and thiopyrimidone derivatives as selective COX-2 inhibitors: Synthesis, biological evaluation, and docking studies
score: 2.049802, European Journal of Medicinal Chemistry, 2012, Basile, Livia et. al.
Analogues of the potential antipsychotic agent 1192U90: amide modifications
score: 2.049753, Bioorganic & Medicinal Chemistry, 1998, Navas III, Frank et. al.
Facile synthesis of de-O-sulfated salacinols: Revision of the structure of neosalacinol, a potent α-glucosidase inhibitor
score: 2.0489907, Bioorganic & Medicinal Chemistry Letters, 2009, Tanabe, Genzoh et. al.
Polysubstituted pyrazoles, part 5. 1 1 For part 4: see Ref. [18]. Synthesis of new 1-(4-chlorophenyl)-4-hydroxy-1 H-pyrazole-3-carboxylic acid hydrazide analogs and some derived ring systems. A novel class of potential antitumor and anti-HCV agents
score: 2.048951, European Journal of Medicinal Chemistry, 2003, Rostom, Sherif A.F; Shalaby, Manal A; El-Demellawy, Maha A
Structure–activity relationships of arylbenzofuran H 3 receptor antagonists
score: 2.0479644, Bioorganic & Medicinal Chemistry Letters, 2005, Gfesser, Gregory A. et. al.
Biological characterization of novel inhibitors of the gram-positive DNA polymerase IIIC enzyme.
score: 2.0478068, Antimicrobial agents and chemotherapy, 2005, Kuhl, Alexander et. al.
Synthesis and biological properties of new 5-nitroindazole derivatives
score: 2.0468795, Bioorganic & Medicinal Chemistry, 2005, Arán, Vicente J. et. al.
Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors
score: 2.0463483, Bioorganic & Medicinal Chemistry, 2001, Aoyama, Yasunori et. al.
A new series of N5 derivatives of the 1,1,5-trimethylfuro[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes
score: 2.0460247, Bioorganic & Medicinal Chemistry Letters, 2012, Pham, The Hien et. al.
Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
score: 2.0452897, Antimicrobial agents and chemotherapy, 2012, Eakin, Ann E et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.0447957, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 2.0445229, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 2.0445229, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 2.0445229, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation
score: 2.0438359, Bioorganic & Medicinal Chemistry Letters, 2012, Procopiou, Panayiotis A. et. al.
Discovery of a Novel Series of 4-Quinolone JNK Inhibitors
score: 2.0432997, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents
score: 2.042124, Bioorganic & Medicinal Chemistry Letters, 2012, Gavade, Sandip N. et. al.
Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents
score: 2.042124, Bioorganic & Medicinal Chemistry Letters, 2012, Gavade, Sandip N. et. al.
Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the α-ketoacid motif
score: 2.0420781, Bioorganic & Medicinal Chemistry, 2004, Chen, Yen Ting; Seto, Christopher T
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization
score: 2.0417949, Bioorganic & Medicinal Chemistry, 2012, Prakasham, A.P. et. al.
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization
score: 2.0417949, Bioorganic & Medicinal Chemistry, 2012, Prakasham, A.P. et. al.
Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives
score: 2.0417756, Bioorganic & Medicinal Chemistry Letters, 2013, Castro-Castillo, Vicente et. al.
Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles
score: 2.0413633, Bioorganic & Medicinal Chemistry Letters, 2006, Minhas, Gurpreet Singh et. al.
Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU
score: 2.0411408, European Journal of Medicinal Chemistry, 2012, Min, Jun; Lin, Da; Zhang, Qingye; Zhang, Jibing; Yu, Ziniu
Virtual screening leads to the discovery of novel non-nucleotide P2Y1 receptor antagonists
score: 2.0409121, Bioorganic & Medicinal Chemistry, 2012, Costanzi, Stefano et. al.
Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo
score: 2.0408755, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Hui; He, Xiao-Qiang
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0402644, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0402644, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0402644, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 2.0398025, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 2.0398025, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphospate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 2.0398025, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR
score: 2.0396099, Bioorganic & Medicinal Chemistry, 2006, Tamura, Hiroto et. al.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
score: 2.039079, European Journal of Medicinal Chemistry, 2012, Menendez, Christophe et. al.
Design and synthesis of N-benzylpiperidine–purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase
score: 2.0388145, Bioorganic & Medicinal Chemistry, 2005, Rodríguez-Franco, María Isabel et. al.
Design, synthesis and early structure–activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate
score: 2.037935, Bioorganic & Medicinal Chemistry, 2000, Schlitzer, Martin et. al.
Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
score: 2.0376611, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
score: 2.0376611, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
A new inhibitor design strategy for carboxypeptidase A as exemplified by N-(2-chloroethyl)- N-methylphenylalanine
score: 2.0375778, Bioorganic & Medicinal Chemistry, 2001, Park, Jung Dae; Lee, Kyung Joo; Kim, Dong H.
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH 3 receptor affinities
score: 2.0375541, Bioorganic & Medicinal Chemistry, 2003, Graßmann, Sven et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0375322, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Structure–activity relationships of globomycin analogues as antibiotics
score: 2.0373376, Bioorganic & Medicinal Chemistry, 2004, Kiho, Toshihiro et. al.
Synthesis and SAR of tetracyclic pyrroloquinolones as phosphodiesterase 5 inhibitors
score: 2.0371516, Bioorganic & Medicinal Chemistry, 2004, Jiang, Weiqin et. al.
Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A
score: 2.0371259, Bioorganic & Medicinal Chemistry, 2006, Park, Jewn Giew et. al.
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
score: 2.0370042, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Synthesis and anticancer activity of a series of norcantharidin analogues
score: 2.0368929, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH 2 derivatives
score: 2.0367983, Bioorganic & Medicinal Chemistry, 1996, Weng, Jian Hui et. al.
Molecular Modeling, Structure–Activity Relationships and Functional Antagonism Studies of 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketones as a Novel Class of Dopamine Transporter Inhibitors
score: 2.0364879, Bioorganic & Medicinal Chemistry, 2001, Wang, Shaomeng et. al.
Bicyclic carbohydrate-derived scaffolds for combinatorial libraries
score: 2.0364625, Bioorganic & Medicinal Chemistry, 2006, Cervi, Giovanni et. al.
Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones
score: 2.0360392, European Journal of Medicinal Chemistry, 2006, Anquetin, Guillaume et. al.
Contribution to investigation of antimicrobial activity of styrylquinolines
score: 2.0359869, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Contribution to investigation of antimicrobial activity of styrylquinolines
score: 2.0359869, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Contribution to investigation of antimicrobial activity of styrylquinolines
score: 2.0359869, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives
score: 2.0355668, Bioorganic & Medicinal Chemistry, 2006, Costa, Marilia S. et. al.
Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones
score: 2.0349344, Bioorganic & Medicinal Chemistry, 2002, Bruno, G et. al.
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives
score: 2.0338431, Bioorganic & Medicinal Chemistry, 2005, Wang, Tai-Chi et. al.
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
score: 2.0337367, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Junxing et. al.
3D-QSAR studies of pyruvate dehydrogenase kinase inhibitors based on a divide and conquer strategy
score: 2.033443, Bioorganic & Medicinal Chemistry, 2004, Aboye, Teshome Leta et. al.
Synthesis and Biological Properties of Amino Acid Amide Ligand-Based Pyridinioalkanoyl Thioesters as Anti-HIV Agents
score: 2.0330847, Bioorganic & Medicinal Chemistry, 2002, Song, Yongsheng et. al.
Bisquaternary caracurine V and iso-caracurine V salts as ligands for the muscle type of nicotinic acetylcholine receptors: SAR and QSAR studies
score: 2.0329276, Bioorganic & Medicinal Chemistry, 2004, Zlotos, D.P. et. al.
The cytotoxicity of ortho alkyl substituted 4-X-phenols: A QSAR based on theoretical bond lengths and electron densities
score: 2.0323665, Bioorganic & Medicinal Chemistry Letters, 2006, Loader, R.J.; Singh, N.; O’Malley, P.J.; Popelier, P.L.A.
Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores
score: 2.0322233, Bioorganic & Medicinal Chemistry, 2006, Koufaki, Maria et. al.
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
score: 2.0322075, Bioorganic & Medicinal Chemistry Letters, 2012, Hansen, Finn K. et. al.
Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1
score: 2.0312991, Bioorganic & Medicinal Chemistry, 2006, Lazo, John S. et. al.
Three-dimensional quantitative structure–activity relationship (3 D-QSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors
score: 2.0312556, Bioorganic & Medicinal Chemistry Letters, 2006, Shaikh, Abdul Rajjak et. al.
Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent
score: 2.0306356, Bioorganic & Medicinal Chemistry Letters, 2012, Hatnapure, Girish D. et. al.
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 2.0306091, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 2.0306091, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 2.0306091, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists
score: 2.0305613, Bioorganic & Medicinal Chemistry Letters, 2013, Fevig, John M. et. al.
Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers
score: 2.0303903, Bioorganic & Medicinal Chemistry Letters, 2012, Kers, Inger et. al.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 2.0303774, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain
score: 2.0303701, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain
score: 2.0303701, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain
score: 2.0303701, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
score: 2.0295312, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
score: 2.0295312, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 2.0292827, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 2.0292827, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 2.0292827, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
A facile route to paclitaxel C-10 carbamates
score: 2.0290584, Bioorganic & Medicinal Chemistry Letters, 2005, Ballatore, Carlo et. al.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs
score: 2.0287126, Bioorganic & Medicinal Chemistry Letters, 2012, Ochiana, Stefan O. et. al.
Biaryl diacid inhibitors of human s-PLA 2 with anti-inflammatory activity
score: 2.0281779, Bioorganic & Medicinal Chemistry, 2000, Springer, Dane M. et. al.
Construction of a three-dimensional pharmacophore for Bcl-2 inhibitors by flexible docking and the multiple copy simultaneous search method
score: 2.0274409, Bioorganic & Medicinal Chemistry, 2007, Zheng, Can-Hui et. al.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0273767, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
score: 2.0273336, European Journal of Medicinal Chemistry, 2012, Bargiotti, Alberto et. al.
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
score: 2.0273336, European Journal of Medicinal Chemistry, 2012, Bargiotti, Alberto et. al.
Identification of a dual δ OR antagonist/ μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.027251, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Synthesis and biological evaluation of B-ring analogues of (−)-rhazinilam
score: 2.026963, Bioorganic & Medicinal Chemistry, 2006, Décor, Anne et. al.
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
score: 2.0267053, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
score: 2.0267053, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
score: 2.0267053, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Conformationally rigid N-acyl-5-alkyl- l-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors
score: 2.0254761, Bioorganic & Medicinal Chemistry, 2003, Wallén, Erik A.A. et. al.
Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases
score: 2.0251869, Bioorganic & Medicinal Chemistry, 2006, Bhuiyan, Mohammed P.I. et. al.
Novel cinnoline-based inhibitors of LRRK2 kinase activity
score: 2.0251865, Bioorganic & Medicinal Chemistry Letters, 2013, Garofalo, Albert W. et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors
score: 2.0250364, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
The 3D-QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and CoMSIA
score: 2.0248874, Bioorganic & Medicinal Chemistry, 2003, Park Choo, Hea-Young et. al.
Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents
score: 2.0248488, European Journal of Medicinal Chemistry, 2006, Abadi, Ashraf H. et. al.
Synthesis and structure–activity relationships of potent and orally active sulfonamide ET B selective antagonists
score: 2.0247361, Bioorganic & Medicinal Chemistry, 2001, Kanda, Yasuhiko et. al.
Non-Peptidic inhibitors of human chymase. Synthesis, structure–activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones
score: 2.0235023, Bioorganic & Medicinal Chemistry, 2001, Akahoshi, Fumihiko et. al.
Isoquinoline derivatives as potent CRTH2 receptor antagonists: Synthesis and SAR
score: 2.0231947, Bioorganic & Medicinal Chemistry Letters, 2012, Nishikawa-Shimono, Rie et. al.
A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers
score: 2.0221272, Bioorganic & Medicinal Chemistry Letters, 2007, Fauq, Abdul H. et. al.
Tyrosinase inhibitory cycloartane type triterpenoids from the methanol extract of the whole plant of Amberboa ramosa Jafri and their structure–activity relationship
score: 2.0220967, Bioorganic & Medicinal Chemistry, 2006, Khan, Mahmud Tareq Hassan et. al.
Identification of specific features of inhibition of PKCβII and its potential lead by shape-based virtual screening and molecular docking studies
score: 2.0218591, Bioorganic & Medicinal Chemistry Letters, 2012, Grewal, Baljinder K.; Elizabeth Sobhia, M.
Identification of specific features of inhibition of PKCβII and its potential lead by shape-based virtual screening and molecular docking studies
score: 2.0218591, Bioorganic & Medicinal Chemistry Letters, 2012, Grewal, Baljinder K.; Elizabeth Sobhia, M.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 2.0215452, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 2.0215452, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 2.0215452, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Synthesis and structure–activity relationships of 2-hydrazinyladenosine derivatives as A2A adenosine receptor ligands
score: 2.0210155, Bioorganic & Medicinal Chemistry, 2013, El-Tayeb, Ali; Gollos, Sabrina
Synthesis, biological evaluation and 3D QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.0209716, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Parallel synthesis and dopamine D 3/D 2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides
score: 2.0208718, Bioorganic & Medicinal Chemistry, 2005, Heidler, Philipp et. al.
Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover
score: 2.0206553, Bioorganic & Medicinal Chemistry Letters, 2012, Manka, Jason T. et. al.
Discovery of new inhibitors of aldose reductase from molecular docking and database screening
score: 2.0201814, Bioorganic & Medicinal Chemistry, 2002, Rastelli, Giulio et. al.
Identification of Aryl Dihydrouracil Derivatives as Palm Initiation Site Inhibitors of HCV NS5B Polymerase
score: 2.0201554, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0196672, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0196672, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0196672, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Riccardin C Derivatives as Anti-MRSA Agents: Structure-Activity Relationship of a Series of Hydroxylated Bis(bibenzyl)s
score: 2.0194425, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
score: 2.018995, Bioorganic & Medicinal Chemistry Letters, 2012, Le, Phuong T. et. al.
Synthesis, molecular modeling and evaluation of novel N′-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation
score: 2.0185314, Bioorganic & Medicinal Chemistry Letters, 2013, Özturan Özer, Eda et. al.
Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.
score: 2.017882, Antimicrobial agents and chemotherapy, 2012, He, Shanshan et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 2.0176064, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 2.0176064, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 2.0176064, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
2,4-Diamino-9 H-pyrimido[4,5- b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations
score: 2.0172815, Bioorganic & Medicinal Chemistry, 2006, Dotzauer, Bernd et. al.
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.01725, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 2.0171745, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 2.0171745, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 2.0171745, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
score: 2.0171162, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Probes for Narcotic Receptor Mediated Phenomena. Part 28: New Opioid Antagonists from Enantiomeric Analogues of 5-(3-Hydroxyphenyl)- N-phenylethylmorphan
score: 2.0166324, Bioorganic & Medicinal Chemistry, 2002, Hashimoto, Akihiro et. al.
Exploration of a binding mode of indole amide analogues as potent histone deacetylase inhibitors and 3D-QSAR analyses
score: 2.0162481, Bioorganic & Medicinal Chemistry, 2005, Guo, Yanshen et. al.
Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis
score: 2.0157942, Bioorganic & Medicinal Chemistry, 2006, Xu, Ze-Qi et. al.
Benzofuranones as potential antinociceptive agents: Structure–activity relationships
score: 2.0157211, European Journal of Medicinal Chemistry, 2012, Gonçalves, Cleiton José et. al.
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease
score: 2.0156724, Bioorganic & Medicinal Chemistry Letters, 2012, Sunose, Mihiro et. al.
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease
score: 2.0156724, Bioorganic & Medicinal Chemistry Letters, 2012, Sunose, Mihiro et. al.
Synthesis of furanone-Based natural product analogues with quorum sensing antagonist activity
score: 2.0154048, Bioorganic & Medicinal Chemistry, 2003, Hjelmgaard, Thomas et. al.
Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides
score: 2.0152979, Bioorganic & Medicinal Chemistry, 2000, Chan, Wai N. et. al.
Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3β (GSK-3β) inhibitors
score: 2.0152302, Bioorganic & Medicinal Chemistry, 2004, Shen, Lan et. al.
Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kβ inhibitors
score: 2.0149635, Bioorganic & Medicinal Chemistry Letters, 2012, Certal, Victor et. al.
Fancy bioisosteres: synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist
score: 2.0144504, Bioorganic & Medicinal Chemistry, 2005, Lenz, Carola et. al.
Synthesis and structure–activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium–calcium exchanger
score: 2.0143716, Bioorganic & Medicinal Chemistry, 2004, Kuramochi, Takahiro et. al.
Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: Discovery of novel orally active inhibitors of human thymidine phosphorylase
score: 2.014356, Bioorganic & Medicinal Chemistry, 2004, Yano, Shingo et. al.
Novel imidazole substituted 6-methylidene-penems as broad-spectrum β-lactamase inhibitors
score: 2.0137134, Bioorganic & Medicinal Chemistry, 2004, Venkatesan, Aranapakam M. et. al.
Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
score: 2.0134415, Bioorganic & Medicinal Chemistry, 2012, Tichý, Michal et. al.
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design
score: 2.0132423, Bioorganic & Medicinal Chemistry, 2006, Tsao, Désirée H.H. et. al.
Oxidative aromatization of Hantzsch 1,4-dihydropyridines in the presence of mixed-addenda vanadomolybdophosphate heteropolyacid, H 6PMo 9V 3O 40
score: 2.0130999, Bioorganic & Medicinal Chemistry Letters, 2007, Heravi, Majid M. et. al.
Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring
score: 2.0125871, Bioorganic & Medicinal Chemistry, 2004, Tanitame, Akihiko et. al.
Synthesis of (4 R,15 R,16 R,21 S)- and (4 R,15 S,16 S,21 S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I
score: 2.0125502, Bioorganic & Medicinal Chemistry, 2006, Makabe, Hidefumi et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.0124942, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Structure-based prediction of Mycobacterium tuberculosis shikimate kinase inhibitors by high-throughput virtual screening
score: 2.0120863, Bioorganic & Medicinal Chemistry Letters, 2008, Segura-Cabrera, Aldo; Rodríguez-Pérez, Mario A.
Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors
score: 2.0119285, Bioorganic & Medicinal Chemistry, 2003, Wheelock, Craig E. et. al.
Inhibition of HIV-1 capsid assembly; optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 2.0111803, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
Structure-based design and synthesis of small molecule protein–tyrosine phosphatase 1B inhibitors 1 A preliminary account of this work have been reported: Burke, T. R., Jr.; Yao, Z. J.; Ye, B.; Wang, S.; Zhang, Z. Y. Structure-based design of protein–tyrosine phosphatase inhibitors. Presented at the 213th National ACS Meeting, San Francisco, CA, April 13–17, 1997; MEDI-313. 1
score: 2.0110696, Bioorganic & Medicinal Chemistry, 1998, Yao, Zhu-Jun et. al.
Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors
score: 2.0109852, Bioorganic & Medicinal Chemistry, 2004, Ochiai, Hiroshi et. al.
Design, synthesis and biological evaluation of pyridine-phenylpiperazines: A novel series of potent and selective α 1a-adrenergic receptor antagonist
score: 2.0108875, Bioorganic & Medicinal Chemistry, 2000, Kuo, Gee-Hong et. al.
Design, Synthesis, Biochemical Studies, Cellular Characterization, and Structure-Based Computational Studies of Small Molecules Targeting the Urokinase Receptor
score: 2.0108615, Bioorganic & Medicinal Chemistry, 2012, Wang, Fang et. al.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
score: 2.0108378, Bioorganic & Medicinal Chemistry Letters, 2012, Ji, Zhiqin et. al.
Structure-Based design of nonpeptide inhibitors of interleukin-1β converting enzyme (ICE, Caspase-1)
score: 2.0108154, Bioorganic & Medicinal Chemistry, 2002, Shahripour, Aurash B et. al.
Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides
score: 2.0108051, European Journal of Medicinal Chemistry, 2012, Banerjee, Moloy et. al.
New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: Quantitative structure–activity relationship studies
score: 2.0107188, Bioorganic & Medicinal Chemistry, 2005, Aguirre, Gabriela et. al.
Linking CoMFA and protein homology models of enzyme–inhibitor interactions: an application to non-steroidal aromatase inhibitors
score: 2.0106433, Bioorganic & Medicinal Chemistry, 2000, Cavalli, Andrea et. al.
Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore
score: 2.0105818, European Journal of Medicinal Chemistry, 2005, Singh, Sunil K. et. al.
Unbiased binding assays for discovering small-molecule probes and drugs
score: 2.0103881, Bioorganic & Medicinal Chemistry, 2012, Kemp, Melissa M.; Weïwer, Michel; Koehler, Angela N.
Synthesis and biological evaluation of optically active conjugated γ- and δ-lactone derivatives
score: 2.0101562, Bioorganic & Medicinal Chemistry Letters, 2012, Şardan, Melis et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 2.0100312, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 2.0100312, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 2.0100312, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
score: 2.0097174, European Journal of Medicinal Chemistry, 2012, Tukulula, Matshawandile et. al.
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
score: 2.0097174, European Journal of Medicinal Chemistry, 2012, Tukulula, Matshawandile et. al.
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
score: 2.0097174, European Journal of Medicinal Chemistry, 2012, Tukulula, Matshawandile et. al.
Studies on Anti- Helicobacter pylori Agents. Part 1: Benzyloxyisoquinoline Derivatives
score: 2.0096847, Bioorganic & Medicinal Chemistry, 1999, Yoshida, Yoshiki et. al.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.0092506, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.0092506, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.0092506, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Convenient synthesis of 3- and 6-deoxy- d- myo-inositol phosphate analogues from (+)- epi- and (−)- vibo-quercitols
score: 2.0085025, Bioorganic & Medicinal Chemistry Letters, 2006, Ogawa, Seiichiro; Tezuka, Yoji
Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.008217, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors
score: 2.0080424, Bioorganic & Medicinal Chemistry Letters, 2012, Close, Joshua et. al.
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors
score: 2.0080424, Bioorganic & Medicinal Chemistry Letters, 2012, Close, Joshua et. al.
Synthesis and antibacterial activity of 4″- O-heteroarylcarbamoyl derivatives of macrolide
score: 2.0080009, Bioorganic & Medicinal Chemistry Letters, 2008, Xu, Peng et. al.
Syntheses and structure–activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents
score: 2.0079579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Syntheses and structure–activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents
score: 2.0079579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Syntheses and structure–activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents
score: 2.0079579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
score: 2.007647, Bioorganic & Medicinal Chemistry Letters, 2012, Baciu-Atudosie, Lavinia et. al.
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
score: 2.007647, Bioorganic & Medicinal Chemistry Letters, 2012, Baciu-Atudosie, Lavinia et. al.
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
score: 2.007647, Bioorganic & Medicinal Chemistry Letters, 2012, Baciu-Atudosie, Lavinia et. al.
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor
score: 2.0073487, Bioorganic & Medicinal Chemistry Letters, 2012, Martínez González, Sonia et. al.
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor
score: 2.0073487, Bioorganic & Medicinal Chemistry Letters, 2012, Martínez González, Sonia et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 2.0070385, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 2.0070385, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 2.0070385, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety
score: 2.0068233, European Journal of Medicinal Chemistry, 2012, Feng, Lianshun et. al.
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors
score: 2.0068073, Bioorganic & Medicinal Chemistry Letters, 2012, Pajouhesh, Hassan et. al.
Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A
score: 2.0067262, Bioorganic & Medicinal Chemistry, 2006, Merino, Isidro et. al.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
score: 2.0066595, Bioorganic & Medicinal Chemistry Letters, 2012, Ji, Zhiqin et. al.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
score: 2.0066595, Bioorganic & Medicinal Chemistry Letters, 2012, Ji, Zhiqin et. al.
Important pharmacophoric features of pan PPAR agonists: Common chemical feature analysis and virtual screening
score: 2.0062181, European Journal of Medicinal Chemistry, 2009, Sundriyal, Sandeep; Bharatam, Prasad V.
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
score: 2.0056247, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes
score: 2.0051793, Bioorganic & Medicinal Chemistry, 2006, Crane, Louis et. al.
A cyclic PNA-based compound targeting domain IV of HCV IRES RNA inhibits in vitro IRES-dependent translation
score: 2.0051682, Bioorganic & Medicinal Chemistry, 2005, Caldarelli, Sergio A. et. al.
Novel strategies for the solid phase synthesis of substituted indolines and indoles
score: 2.0051613, Bioorganic & Medicinal Chemistry, 2003, Nicolaou, K.C et. al.
Using self-organizing maps to accelerate similarity search
score: 2.0050237, Bioorganic & Medicinal Chemistry, 2012, Bonachera, Fanny et. al.
Using self-organizing maps to accelerate similarity search
score: 2.0050237, Bioorganic & Medicinal Chemistry, 2012, Bonachera, Fanny et. al.
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine
score: 2.0043429, European Journal of Medicinal Chemistry, 2012, Annedi, Subhash C. et. al.
Chemical methods for the synthesis and modification of neoclerodane diterpenes
score: 2.0042201, Bioorganic & Medicinal Chemistry Letters, 2009, Lozama, Anthony; Prisinzano, Thomas E.
CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]- N, N ′-diphenylureas
score: 2.0039594, Bioorganic & Medicinal Chemistry, 2004, Imamura, Shinichi et. al.
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical conformation
score: 2.0031189, Bioorganic & Medicinal Chemistry, 1997, Albert, Jeffrey S.; Peczuh, Mark W.; Hamilton, Andrew D.
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical conformation
score: 2.0031189, Bioorganic & Medicinal Chemistry, 1997, Albert, Jeffrey S.; Peczuh, Mark W.; Hamilton, Andrew D.
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
score: 2.0029286, Bioorganic & Medicinal Chemistry Letters, 2012, Le, Phuong T. et. al.
SAR Studies of 3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one as Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase
score: 2.0027185, Bioorganic & Medicinal Chemistry, 2002, Lin, Yung-Lung et. al.
New potential inhibitors of DNA topoisomerase. Part II: Design and synthesis of α-lapachone derivatives under microwave irradiation
score: 2.0026727, Bioorganic & Medicinal Chemistry Letters, 2009, Wei, Ping et. al.
Disubstituted piperidines as potent Orexin (hypocretin) receptor antagonists
score: 2.0025712, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Pharmacology of novel heteroaromatic polycycle antibacterials.
score: 2.0025579, Antimicrobial agents and chemotherapy, 2003, Gross, M et. al.
Synthesis and antiviral activity of 4,4′-(arylmethylene)bis(1 H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV)
score: 2.0025191, Bioorganic & Medicinal Chemistry Letters, 2009, Sujatha, Kuppusamy et. al.
Comparative molecular field analysis and comparative molecular similarity indices analysis of human thymidine kinase 1 substrates
score: 2.0021696, Bioorganic & Medicinal Chemistry, 2005, Bandyopadhyaya, Achintya K. et. al.
3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis
score: 2.0020988, Bioorganic & Medicinal Chemistry, 2005, Bhongade, Bhoomendra A. et. al.
Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5- c]pyridine bioisosteres of arecoline
score: 2.0018079, Bioorganic & Medicinal Chemistry, 1999, Pedersen, Henrik et. al.
Exploring the PDE5 H-pocket by Ensemble Docking and Structure-based Design and Synthesis of Novel β-Carboline Derivatives
score: 2.0017149, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa
score: 2.0016334, Bioorganic & Medicinal Chemistry, 2005, Zhan, Zha-Jun; Fan, Cheng-Qi; Ding, Jian; Yue, Jian-Min
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 2.0014001, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 2.0014001, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 2.0014001, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity
score: 2.0011495, Bioorganic & Medicinal Chemistry, 2005, Büttner, Frank et. al.
Synthesis of complex δ-acetylenic amino acids as potential multisubstrate adduct inhibitors of methyltransferases
score: 2.0010322, Bioorganic & Medicinal Chemistry, 1996, Burns, Mark R.; Coward, James K.
Theoretical study of gas-phase acidity, p K a, lipophilicity, and solubility of some biologically active sulfonamides
score: 2.0008693, Bioorganic & Medicinal Chemistry, 2004, Remko, Milan; von der Lieth, Claus-Wilhelm
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0004304, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0004304, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0004304, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α,25-dihydroxyvitamin D 3: synthesis and preliminary biological evaluation
score: 2.00032, Bioorganic & Medicinal Chemistry, 2005, Hatcher, Mark A. et. al.
DFT-based ranking of zinc-binding groups in histone deacetylase inhibitors
score: 1.999762, Bioorganic & Medicinal Chemistry, 2005, Vanommeslaeghe, K.; Loverix, S.; Geerlings, P.; Tourwé, D.
Novel acridinedione derivatives: Design, Synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 1.9987524, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines
score: 1.9986523, Bioorganic & Medicinal Chemistry, 2005, Moon, Byung Seok; Lee, Byoung Se; Chi, Dae Yoon
Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2
score: 1.9986091, Bioorganic & Medicinal Chemistry Letters, 2012, Delouvrié, Bénédicte et. al.
Synthesis of indolizidinone analogues of cytotoxic alkaloids: monocyclic precursors are also active
score: 1.9985987, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues
score: 1.9983228, Bioorganic & Medicinal Chemistry Letters, 1998, Highfield, Jackie A. et. al.
Design, synthesis and structure–activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.9981628, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression
score: 1.9980151, Bioorganic & Medicinal Chemistry Letters, 2013, Gillman, Kevin W. et. al.
Pleuromutilins. Part 1
score: 1.997613, Bioorganic & Medicinal Chemistry, 2001, Brooks, Gerald et. al.
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives
score: 1.9975048, Bioorganic & Medicinal Chemistry Letters, 2012, LeTourneau, Nicolas et. al.
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives
score: 1.9975048, Bioorganic & Medicinal Chemistry Letters, 2012, LeTourneau, Nicolas et. al.
Synthesis of new bergenin derivatives as potent inhibitors of inflammatory mediators NO and TNF-α
score: 1.9974694, Bioorganic & Medicinal Chemistry Letters, 2012, Shah, Muhammad Raza et. al.
Combinatorial chemistry of hydantoins
score: 1.9973869, Bioorganic & Medicinal Chemistry Letters, 1998, Boeijen, Astrid; Kruijtzer, John A.W; Liskamp, Rob M.J
HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo- 2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy- 2H-quinolizin-2-one derivatives
score: 1.9972004, Bioorganic & Medicinal Chemistry Letters, 2009, Wang, Guangyi et. al.
Development of first photoresponsive prodrug of paclitaxel
score: 1.9969594, Bioorganic & Medicinal Chemistry Letters, 2006, Skwarczynski, Mariusz et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
score: 1.9965499, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
score: 1.9965499, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
score: 1.9965499, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
11 H-Isoquino[4,3- c]cinnolin-12-ones
score: 1.9956233, Bioorganic & Medicinal Chemistry, 2004, Ruchelman, Alexander L et. al.
Design and synthesis of 4H-3-(2-Phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists
score: 1.9951512, Bioorganic & Medicinal Chemistry, 2003, Akbarzadeh, Tahmineh et. al.
Design and an efficient synthesis of new thiorotenone derivatives
score: 1.9950745, Bioorganic & Medicinal Chemistry Letters, 2010, Yao, Changsheng et. al.
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
score: 1.9947721, Bioorganic & Medicinal Chemistry Letters, 2012, Chang, Wonsuk et. al.
Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells
score: 1.994681, Bioorganic & Medicinal Chemistry Letters, 2013, Yoon, Hyuk et. al.
Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: A single-step synthesis from benzenesulfonamide via hemiaminal
score: 1.994389, European Journal of Medicinal Chemistry, 2007, Singh, Sunil K. et. al.
Efficient synthesis of 3′-glycosylated LacNAc-based oligosaccharides
score: 1.9941771, Bioorganic & Medicinal Chemistry Letters, 1998, Ding, Yili; Fukuda, Minrou; Hindsgaul, Ole
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry
score: 1.9939713, Bioorganic & Medicinal Chemistry, 2008, Lam, Son N. et. al.
Design, Synthesis and Biological Evaluation of Potent NAD+-dependent DNA Ligase Inhibitors as Potential Antibacterial Agents. Part I: Aminoalkoxypyrimidine Carboxamides
score: 1.9937359, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Synthesis, screening and quantitative structure–activity relationship (QSAR) studies of some glutamine analogues for possible anticancer activity
score: 1.9936147, Bioorganic & Medicinal Chemistry, 2002, Srikanth, K.; Kumar, Ch.Anil; Ghosh, Balaram; Jha, Tarun
Synthesis and SAR Development of Novel mGluR1 Antagonists for the Treatment of Chronic Pain
score: 1.9932479, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
CoMFA, LeapFrog and blind docking studies on sulfonanilide derivatives acting as selective aromatase expression regulators
score: 1.9930291, European Journal of Medicinal Chemistry, 2009, Gueto, Carlos; Torres, Juan; Vivas-Reyes, Ricardo
Known drug space as a metric in exploring the boundaries of drug-like chemical space
score: 1.9922456, European Journal of Medicinal Chemistry, 2009, Mirza, Amin; Desai, Radha; Reynisson, Jóhannes
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists
score: 1.9921353, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists
score: 1.9921353, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists
score: 1.9921353, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
Novel vitamin D 3 antipsoriatic antedrugs: 16-En-22-oxa-1α,25-(OH) 2D 3 analogs
score: 1.9921348, Bioorganic & Medicinal Chemistry, 2006, Shimizu, Kazuki et. al.
Thiorhodamines Containing Amide and Thioamide Functionality as Inhibitors of the ATP-Binding Cassette Drug Transporter P-glycoprotein (ABCB1)
score: 1.9917046, Bioorganic & Medicinal Chemistry, 2012, Orchard, Alexandra et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 1.9916825, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents
score: 1.9912572, Bioorganic & Medicinal Chemistry, 2006, Rochais, C.; Lisowski, V.; Dallemagne, P.; Rault, S.
A novel photoaffinity probe for the LTD 4 receptor
score: 1.9911621, Bioorganic & Medicinal Chemistry, 1998, Gallant, Michel et. al.
Preparation, antibacterial evaluation and preliminary structure–activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives
score: 1.9910585, Bioorganic & Medicinal Chemistry Letters, 2012, Ouyang, Liang et. al.
A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure–activity relationships
score: 1.9910124, Bioorganic & Medicinal Chemistry, 2005, Nomura, Takashi et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.9907447, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.9907447, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
In vitro solubility, stability and permeability of novel quercetin–amino acid conjugates
score: 1.9906238, Bioorganic & Medicinal Chemistry, 2009, Kim, Mi Kyoung et. al.
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.9905811, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.9905811, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.9905811, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1
score: 1.9902691, Bioorganic & Medicinal Chemistry Letters, 2000, Uckun, Fatih M. et. al.
Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems
score: 1.9892515, Bioorganic & Medicinal Chemistry, 2000, Imamura, Hideaki et. al.
Design, synthesis and Structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.9890826, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins
score: 1.988991, Bioorganic & Medicinal Chemistry, 2005, LeBlanc, Regan et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 1.9881919, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 1.9872957, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Molecular encapsulation of 5-nitroindazole derivatives in 2,6-dimethyl-β-cyclodextrin: Electrochemical and spectroscopic studies
score: 1.9867941, Bioorganic & Medicinal Chemistry, 2009, Pérez-Cruz, Fernanda et. al.
Syntheses of novel heterocycles as anticancer agents
score: 1.9866842, Bioorganic & Medicinal Chemistry, 2005, Chauhan, Prem M.S. et. al.
Design, synthesis and structure–activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.9865494, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Syntheses and DNA-binding studies of a series of unsymmetrical cyanine dyes: structural influence on the degree of minor groove binding to natural DNA
score: 1.9864574, Bioorganic & Medicinal Chemistry, 2004, Karlsson, H.Jonas et. al.
Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels
score: 1.9857253, Bioorganic & Medicinal Chemistry Letters, 2013, Ortar, Giorgio et. al.
Coumarin–trioxane hybrids: Synthesis and evaluation as a new class of antimalarial scaffolds
score: 1.9855804, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human β 3-adrenergic receptor agonists with high cell permeability
score: 1.98547, Bioorganic & Medicinal Chemistry, 2005, Mizuno, Kazuhiro et. al.
Novel AI-2 quorum sensing inhibitors in Vibrio harveyi identified through structure-based virtual screening
score: 1.9851763, Bioorganic & Medicinal Chemistry Letters, 2012, Zhu, Peng et. al.
Synthesis, and cytotoxic activity of some novel indolo[2,3- b]quinoline derivatives
score: 1.9850266, Bioorganic & Medicinal Chemistry, 1999, Kaczmarek, et. al.
Syntheses of Novel Diphenyl Piperazine Derivatives and Their Activities as Inhibitors of Dopamine Uptake in the Central Nervous System
score: 1.984856, Bioorganic & Medicinal Chemistry, 2003, Kimura, Makoto et. al.
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors
score: 1.9847433, Bioorganic & Medicinal Chemistry, 2006, Woods, Keith W. et. al.
Nitrophenyl Derivatives as Aldose Reductase Inhibitors
score: 1.9847139, Bioorganic & Medicinal Chemistry, 2002, Costantino, Luca et. al.
Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide
score: 1.9843546, Bioorganic & Medicinal Chemistry, 2006, Parkkari, Teija et. al.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
score: 1.9842992, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose.
score: 1.9837389, Antimicrobial agents and chemotherapy, 2001, Ma, Y et. al.
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease
score: 1.9835598, Bioorganic & Medicinal Chemistry Letters, 2012, Sunose, Mihiro et. al.
Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists
score: 1.9830647, Bioorganic & Medicinal Chemistry, 2012, Negoro, Kenji et. al.
Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides
score: 1.9830036, Bioorganic & Medicinal Chemistry, 2004, Epperson, James R. et. al.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.9824281, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.9824281, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Potential synergism and inhibitors to multiple target enzymes of Xuefu Zhuyu Decoction in cardiac disease therapeutics: A computational approach
score: 1.9822791, Bioorganic & Medicinal Chemistry Letters, 2007, Huang, Qin; Qiao, Xuebin; Xu, Xiaojie
Synthesis of N-(β- D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-β- D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase
score: 1.9822024, Bioorganic & Medicinal Chemistry, 2004, Györgydeák, Zoltán et. al.
Synthesis and antimicrobial activities of structurally novel S,S’-bis(hetero-substituted) disulfides
score: 1.9820151, Bioorganic & Medicinal Chemistry Letters, 2012, Ramaraju, Praveen et. al.
Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression
score: 1.9820131, Bioorganic & Medicinal Chemistry, 2013, Holland, Jason P. et. al.
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
score: 1.981265, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Mo et. al.
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
score: 1.981265, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Mo et. al.
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
score: 1.9811823, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
score: 1.9811823, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
score: 1.9811823, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3-D QSAR methods
score: 1.9811719, Bioorganic & Medicinal Chemistry, 2002, Sippl, Wolfgang
Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents
score: 1.9810643, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Kai-Kai et. al.
Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase
score: 1.9809594, Bioorganic & Medicinal Chemistry Letters, 2010, Gupta, Pawan et. al.
Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines † † See ref. 1.
score: 1.980874, Bioorganic & Medicinal Chemistry, 2002, Ng, Howard P. et. al.
Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor
score: 1.9806539, Bioorganic & Medicinal Chemistry Letters, 2004, Kim, Dae-Kee; Kim, Joonseop; Park, Hyun-Ju
Synthesis and structure–activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1)
score: 1.9806405, Bioorganic & Medicinal Chemistry Letters, 2012, Shreder, Kevin R. et. al.
Synthesis and structure–activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1)
score: 1.9806405, Bioorganic & Medicinal Chemistry Letters, 2012, Shreder, Kevin R. et. al.
Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor
score: 1.9804196, Bioorganic & Medicinal Chemistry Letters, 2012, Haddad, Terra et. al.
A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles
score: 1.9802503, European Journal of Medicinal Chemistry, 2012, Almansour, Abdulrahman I. et. al.
A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles
score: 1.9802503, European Journal of Medicinal Chemistry, 2012, Almansour, Abdulrahman I. et. al.
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity
score: 1.9802007, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity
score: 1.9802007, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity
score: 1.9802007, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: Synthesis, DNA binding and cytotoxicity studies
score: 1.980183, Bioorganic & Medicinal Chemistry, 1997, Brooks, Natalie et. al.
Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: Synthesis, DNA binding and cytotoxicity studies
score: 1.980183, Bioorganic & Medicinal Chemistry, 1997, Brooks, Natalie et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain
score: 1.9792227, Bioorganic & Medicinal Chemistry Letters, 2012, Nagase, Hiroshi et. al.
AMBER force field implementation of the boronate function to simulate the inhibition of β-lactamases by alkyl and aryl boronic acids
score: 1.9792097, European Journal of Medicinal Chemistry, 2005, Tafi, Andrea et. al.
Molecular docking and 3-D-QSAR studies on the possible antimalarial mechanism of artemisinin analogues
score: 1.9790787, Bioorganic & Medicinal Chemistry, 2002, Cheng, Feng et. al.
Design and Optimization of Novel (2S,4S,5S)-5-Amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as Renin Inhibitors
score: 1.9790047, Bioorganic & Medicinal Chemistry Letters, 2012, Nakamura, Yuji et. al.
Synthesis and evaluation of diazine containing bioisosteres of (−)-ferruginine as ligands for nicotinic acetylcholine receptors
score: 1.9787291, Bioorganic & Medicinal Chemistry, 2001, Gündisch, Daniela et. al.
Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives
score: 1.9784605, Bioorganic & Medicinal Chemistry, 2005, Hisamichi, Hiroyuki et. al.
Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates
score: 1.9778788, Bioorganic & Medicinal Chemistry, 2006, Zhao, Ming et. al.
Carbonic anhydrase inhibitors: Binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties
score: 1.9776931, Bioorganic & Medicinal Chemistry Letters, 2007, Fiore, Anna Di et. al.
Seven-membered cycloplatinated complexes as a new family of anticancer agents. X-ray characterization and preliminary biological studies
score: 1.9774463, European Journal of Medicinal Chemistry, 2012, Cortés, Roldán et. al.
Identification of novel muscarinic M 3 selective antagonists with a conformationally restricted Hyp-Pro spacer
score: 1.9774152, Bioorganic & Medicinal Chemistry Letters, 2003, Sagara, Yufu et. al.
6-acylamino-2-[(ethylsulfonyl)oxy]-1 H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity
score: 1.9768889, Bioorganic & Medicinal Chemistry, 2001, Vagnoni, Lisa M.; Gronostaj, Michael; Kerrigan, John E.
A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
score: 1.9761929, European Journal of Medicinal Chemistry, 2012, Venkateswararao, Eeda et. al.
3D-QSAR analysis of sialyltransferase inhibitors
score: 1.9761668, Bioorganic & Medicinal Chemistry, 2003, Wang, Xiaofang et. al.
InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents
score: 1.9760747, Bioorganic & Medicinal Chemistry Letters, 2012, Mulakayala, Naveen et. al.
Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids
score: 1.9760724, Bioorganic & Medicinal Chemistry, 2003, de Candia, Modesto et. al.
Design of potent inhibitors for Schistosoma japonica glutathione S-transferase
score: 1.9753302, Bioorganic & Medicinal Chemistry, 2006, Jao, Shu-Chuan; Chen, Jessica; Yang, Kelvin; Li, Wen-Shan
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents
score: 1.9753285, Bioorganic & Medicinal Chemistry, 2006, Dupeyre, Grégory et. al.
Synthesis, antiplatelet activity and comparative molecular field analysis of substituted 2-amino-4 H-pyrido[1,2- a]pyrimidin-4-ones, their congeners and isosteric analogues
score: 1.9750792, Bioorganic & Medicinal Chemistry, 2000, Roma, Giorgio et. al.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
score: 1.9740616, European Journal of Medicinal Chemistry, 2012, Opsenica, Igor et. al.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
score: 1.9740616, European Journal of Medicinal Chemistry, 2012, Opsenica, Igor et. al.
Synthesis and antitumor activity of water-soluble enediyne compounds related to dynemicin a
score: 1.9728959, Bioorganic & Medicinal Chemistry, 1997, Unno, Ryoichi et. al.
The optimization of pyridazinone series of glucan synthase inhibitors
score: 1.9718729, Bioorganic & Medicinal Chemistry Letters, 2012, Kuang, Rongze et. al.
Sulfone and phosphinic acid analogs of decaprenolphosphoarabinose as potential anti-tuberculosis agents
score: 1.9717771, Bioorganic & Medicinal Chemistry, 2004, Centrone, Charla A.; Lowary, Todd L.
Design, synthesis and evaluation of carbazole derivatives as PPARα/γ dual agonists and antioxidants
score: 1.9713962, Bioorganic & Medicinal Chemistry, 2005, Kumar, Rakesh et. al.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.9706843, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase
score: 1.97022, Bioorganic & Medicinal Chemistry, 2012, Luniwal, Amarjit et. al.
Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase
score: 1.97022, Bioorganic & Medicinal Chemistry, 2012, Luniwal, Amarjit et. al.
Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase
score: 1.97022, Bioorganic & Medicinal Chemistry, 2012, Luniwal, Amarjit et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity
score: 1.9694268, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity
score: 1.9690603, Bioorganic & Medicinal Chemistry Letters, 2012, Jakopović, Ivana Palej et. al.
Benzoheterocyclic Amodiaquine Analogues with Potent Antiplasmodial Activity: Synthesis and Pharmacological Evaluation
score: 1.9683325, Bioorganic & Medicinal Chemistry Letters, 2012, Ongarora, Dennis S.B. et. al.
Lead optimization of 4,4 biaryl piperidine amides as γ-secretase inhibitors
score: 1.9681064, Bioorganic & Medicinal Chemistry Letters, 2012, Close, Joshua et. al.
A multidetachable sulfamate linker successfully used in a solid-Phase strategy to generate libraries of sulfamate and phenol derivatives
score: 1.967398, Bioorganic & Medicinal Chemistry Letters, 2002, Poirier, Donald; Ciobanu, Liviu C.; Bérubé, Marie
Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties
score: 1.9673567, Bioorganic & Medicinal Chemistry, 2012, Ballatore, Carlo et. al.
Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system
score: 1.9672893, Bioorganic & Medicinal Chemistry, 2006, Hwang, Der-Ren et. al.
Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333
score: 1.9669193, Bioorganic & Medicinal Chemistry Letters, 2012, Beinat, Corinne et. al.
Thalidomide analogues demonstrate dual inhibition of both angiogenesis and prostate cancer
score: 1.966874, Bioorganic & Medicinal Chemistry, 2004, Capitosti, Scott M; Hansen, Todd P; Brown, Milton L
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies.
score: 1.9667289, Antimicrobial agents and chemotherapy, 2006, Tasdemir, Deniz et. al.
3D-QSAR study of sulfonamide inhibitors of human carbonic anhydrase II
score: 1.9665477, European Journal of Medicinal Chemistry, 2007, Huang, Huoqiang et. al.
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.9664666, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.9664666, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.9664666, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Synthesis and biological evaluation of novel carbon-11-labelled analogues of citalopram as potential radioligands for the serotonin transporter
score: 1.9664422, Bioorganic & Medicinal Chemistry, 2003, Madsen, Jacob et. al.
Cytotoxicities, cell cycle and caspase evaluations of 1,6-diaryl-3( Z)-hexen-1,5-diynes, 2-(6-aryl-3( Z)-hexen-1,5-diynyl)anilines and their derivatives
score: 1.9662272, Bioorganic & Medicinal Chemistry, 2005, Lin, Chi-Fong et. al.
Design, synthesis, and evaluation of new type of l-amino acids containing pyridine moiety as nitric oxide synthase inhibitor
score: 1.9661622, Bioorganic & Medicinal Chemistry, 2006, Ijuin, Ryosuke; Umezawa, Naoki; Higuchi, Tsunehiko
Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy
score: 1.966055, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Ming et. al.
Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases
score: 1.9651594, Bioorganic & Medicinal Chemistry, 2004, Su, Xiangdong et. al.
Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents
score: 1.9651552, Bioorganic & Medicinal Chemistry Letters, 2012, Avupati, Vasudeva Rao et. al.
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
score: 1.9650876, European Journal of Medicinal Chemistry, 2012, Bargiotti, Alberto et. al.
Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists
score: 1.9649454, Bioorganic & Medicinal Chemistry Letters, 2004, Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Pyrazole CCK 1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free–Wilson additivity
score: 1.9646797, Bioorganic & Medicinal Chemistry Letters, 2006, Sehon, Clark et. al.
Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor
score: 1.9645758, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Heng et. al.
Synthesis of indolizidinone analogues of cytotoxic alkaloids: Monocyclic precursors are also active
score: 1.9641032, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Synthesis of indolizidinone analogues of cytotoxic alkaloids: Monocyclic precursors are also active
score: 1.9641032, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Synthesis of indolizidinone analogues of cytotoxic alkaloids: Monocyclic precursors are also active
score: 1.9641032, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Identification of benzoxazole analogs as novel, S1P3 sparring S1P1 agonists
score: 1.9639793, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors
score: 1.9634315, Bioorganic & Medicinal Chemistry, 2005, Chen, Qiao-Hong; Rao, P.N. Praveen; Knaus, Edward E.
QSAR and 3D-QSAR of phenothiazine type multidrug resistance modulators in P388/ADR cells
score: 1.9631451, Bioorganic & Medicinal Chemistry, 2003, Tsakovska, Ivanka M.
N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators
score: 1.9620402, Bioorganic & Medicinal Chemistry Letters, 2012, Packiarajan, Mathivanan et. al.
Preparation and biological properties of biotinylated PhTX derivatives
score: 1.9615303, Bioorganic & Medicinal Chemistry, 1999, Hashimoto, Masaru et. al.
Structure–activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia
score: 1.9612238, Bioorganic & Medicinal Chemistry, 2012, Fushimi, Nobuhiko et. al.
Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptor
score: 1.9609253, Bioorganic & Medicinal Chemistry Letters, 2005, Pontillo, Joseph et. al.
Anti-human immunodeficiency virus activities of nucleosides and nucleotides: correlation with molecular electrostatic potential data.
score: 1.9607148, Antimicrobial agents and chemotherapy, 2000, Mickle, T; Nair, V
Fragment Informatics and Computational Fragment-Based Drug Design: An Overview and Update.
score: 1.9603748, Medicinal research reviews, 2012, Sheng, Chunquan; Zhang, Wannian
Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies
score: 1.9602722, Bioorganic & Medicinal Chemistry Letters, 2013, Butini, Stefania et. al.
Studies on 3′-quaternary ammonium cephalosporins—III. Synthesis and antibacterial activity of 3′-(3-aminopyrazolium)cephalosporins
score: 1.9598028, Bioorganic & Medicinal Chemistry, 1997, Ohki, Hidenori et. al.
Symmetrical Approach of Spiro-pyrazolidinediones as Acetyl-CoA Carboxylase Inhibitors
score: 1.9596588, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI
score: 1.9596111, Bioorganic & Medicinal Chemistry, 2003, Mayoral, Elena P. et. al.
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors
score: 1.9593714, European Journal of Medicinal Chemistry, 2012, Giraud, Francis et. al.
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors
score: 1.9593714, European Journal of Medicinal Chemistry, 2012, Giraud, Francis et. al.
Synthesis and structure–activity relationships of thioflavone derivatives as specific inhibitors of the ERK-MAP kinase signaling pathway
score: 1.9591853, Bioorganic & Medicinal Chemistry, 2004, Kataoka, Tadashi et. al.
Synthesis and evaluation of a series of 1,4-Diarylbutadienes for anticoccidial activity
score: 1.9586465, Bioorganic & Medicinal Chemistry, 2003, Gage, Jennifer L et. al.
Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities
score: 1.958548, Bioorganic & Medicinal Chemistry, 1997, O'Sullivan, Mary C. et. al.
Synthesis and antitumor activity of novel 10-substituted camptothecin analogues
score: 1.958531, Bioorganic & Medicinal Chemistry, 2006, Li, Qingyong et. al.
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases
score: 1.9584126, Bioorganic & Medicinal Chemistry Letters, 2012, Curtin, Michael L. et. al.
Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties
score: 1.9583092, Bioorganic & Medicinal Chemistry, 2012, Ballatore, Carlo et. al.
2-D and 3-D modeling of imidazoline receptor ligands: Insights into pharmacophore
score: 1.9582503, Bioorganic & Medicinal Chemistry, 1997, Carrieri, A. et. al.
Synthesis and evaluation of analogues of congo red as potential compounds against transmissible spongiform encephalopathies
score: 1.9580165, European Journal of Medicinal Chemistry, 2003, Rudyk, Hélène et. al.
Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide
score: 1.9571976, Bioorganic & Medicinal Chemistry, 2005, Terracciano, Stefania et. al.
Synthesis of Paclitaxel–BGL Conjugates
score: 1.9570321, Bioorganic & Medicinal Chemistry, 2012, Nemoto, Hisao et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.9570041, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.9570041, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.9570041, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter
score: 1.9565796, Bioorganic & Medicinal Chemistry, 2005, Zea-Ponce, Yolanda et. al.
Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors
score: 1.956195, Bioorganic & Medicinal Chemistry, 2004, O'Neill, David J. et. al.
Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
score: 1.9561192, Bioorganic & Medicinal Chemistry Letters, 2012, Khan, Mohammad Faheem et. al.
Inhibition of the complete set of mammalian secreted phospholipases A 2 by indole analogues
score: 1.956069, Bioorganic & Medicinal Chemistry, 2004, Smart, Brian P. et. al.
Dopamine-selective potentiometric responses by new ditopic sensory elements based on a hexahomotrioxacalix[3]arene
score: 1.9554494, Bioorganic & Medicinal Chemistry Letters, 2007, Saijo, Ryosuke et. al.
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR)
score: 1.955142, Bioorganic & Medicinal Chemistry, 2013, Orlandi, Francesca et. al.
in vitro inhibition of the measles virus by novel ring-expanded (‘fat’) nucleoside analogues containing the imidazo[4,5- e] [1,3]diazepine ring system
score: 1.9548515, Bioorganic & Medicinal Chemistry Letters, 2002, Zhang, Ning et. al.
HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides
score: 1.9547287, Bioorganic & Medicinal Chemistry Letters, 2012, St. Laurent, Denis R. et. al.
Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
score: 1.9545278, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Guo Hua et. al.
Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
score: 1.9545278, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Guo Hua et. al.
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules
score: 1.9544411, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules
score: 1.9544411, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules
score: 1.9544411, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
Structure–activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors
score: 1.9544035, Bioorganic & Medicinal Chemistry Letters, 2012, Pajouhesh, Hassan et. al.
Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities
score: 1.9542383, Bioorganic & Medicinal Chemistry, 2012, Shinada, Masashi et. al.
Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors
score: 1.954153, Bioorganic & Medicinal Chemistry, 2005, Franchetti, Palmarisa et. al.
Use of libraries to access new chemical space: applications to CRTH2
score: 1.9539202, Bioorganic & Medicinal Chemistry Letters, 2012, Abid Masood, M. et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.9537544, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.9537544, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.9537544, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
Anticancer activities of novel chalcone and bis-chalcone derivatives
score: 1.953669, Bioorganic & Medicinal Chemistry, 2006, Modzelewska, Aneta et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.9535787, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.9535787, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.9535787, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
score: 1.953332, Bioorganic & Medicinal Chemistry, 2005, Hu, Yonghan et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.9532351, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.9532351, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.9532351, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3 H)-quinazolinone analogs
score: 1.9532258, Bioorganic & Medicinal Chemistry, 2006, Al-Rashood, Sarah T. et. al.
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides
score: 1.9528884, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiaozhuo et. al.
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides
score: 1.9528884, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiaozhuo et. al.
Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy
score: 1.9528114, Bioorganic & Medicinal Chemistry, 2005, Hay, Michael P.; Wilson, William R.; Denny, William A.
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
score: 1.9524902, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
score: 1.9524902, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists
score: 1.9522816, Bioorganic & Medicinal Chemistry Letters, 2012, Poslusney, Michael S. et. al.
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists
score: 1.9522816, Bioorganic & Medicinal Chemistry Letters, 2012, Poslusney, Michael S. et. al.
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists
score: 1.9522816, Bioorganic & Medicinal Chemistry Letters, 2012, Poslusney, Michael S. et. al.
Antiproliferative activity of new 1-aryl-4-amino-1 H-pyrazolo[3,4- d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line
score: 1.9520358, European Journal of Medicinal Chemistry, 2004, Schenone, Silvia et. al.
Molecular modeling analysis of the interaction of novel bis-cationic ligands with the lipid A moiety of lipopolysaccharide
score: 1.9518929, Bioorganic & Medicinal Chemistry Letters, 2006, Guo, Jian-Xin et. al.
Investigation of Beckett–Casy model 3: Synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology
score: 1.9515874, Bioorganic & Medicinal Chemistry Letters, 2010, Nagase, Hiroshi et. al.
Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities
score: 1.9513565, Bioorganic & Medicinal Chemistry, 2002, Miki, Takashi et. al.
Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases
score: 1.9507137, Bioorganic & Medicinal Chemistry, 2012, Bhabak, Krishna P.; Arenz, Christoph
Synthesis and cytotoxic activities of analogues of thuriferic acid
score: 1.9507058, Bioorganic & Medicinal Chemistry, 2002, Madrigal, Blanca et. al.
Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N 1, N 4-dioxide derivatives by complexation with vanadium
score: 1.9499779, Bioorganic & Medicinal Chemistry, 2006, Urquiola, Carolina et. al.
Flavonoids and cinnamic acid esters as inhibitors of fungal 17β-hydroxysteroid dehydrogenase: A synthesis, QSAR and modelling study
score: 1.9496814, Bioorganic & Medicinal Chemistry, 2006, Sova, Matej et. al.
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3)
score: 1.949629, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Essa et. al.
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3)
score: 1.949629, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Essa et. al.
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3)
score: 1.949629, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Essa et. al.
α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4
score: 1.9495279, Bioorganic & Medicinal Chemistry, 2012, Lemonnier, Gérald et. al.
Synthesis, DNA cleavage, and cytotoxicity of a series of bis(propargylic) sulfone crown ethers
score: 1.9493424, Bioorganic & Medicinal Chemistry, 2001, McPhee, Mark M.; Kerwin, Sean M.
Inhibitors of theYersiniaprotein tyrosine phosphatase through high throughput and virtual screening approaches
score: 1.9492831, Bioorganic & Medicinal Chemistry Letters, 2013, Hu, Xin; Vujanac, Milos; Southall, Noel; Erec Stebbins, C.
Synthesis of Constrained Benzocinnolinone Analogues of CEP-26401 (Irdabisant) as Potent, Selective Histamine H3 Receptor Inverse Agonists
score: 1.9492809, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
A new facile chemoenzymatic synthesis of levamisole
score: 1.9489266, Bioorganic & Medicinal Chemistry Letters, 2005, Kamal, Ahmed; Khanna, G.B. Ramesh; Krishnaji, T.; Ramu, R.
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
score: 1.94857, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Betty et. al.
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
score: 1.94857, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Betty et. al.
Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis
score: 1.9480946, Bioorganic & Medicinal Chemistry, 2012, Petch, Donna et. al.
Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure–anti-mycobacterial activities
score: 1.9472863, Bioorganic & Medicinal Chemistry, 2005, Macaev, Fliur et. al.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
score: 1.947213, Bioorganic & Medicinal Chemistry Letters, 2012, McGowan, David et. al.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
score: 1.947213, Bioorganic & Medicinal Chemistry Letters, 2012, McGowan, David et. al.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
score: 1.947213, Bioorganic & Medicinal Chemistry Letters, 2012, McGowan, David et. al.
Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes
score: 1.9471114, Bioorganic & Medicinal Chemistry Letters, 2012, Du, Xiaohui et. al.
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors
score: 1.9464963, European Journal of Medicinal Chemistry, 2012, Gu, Shuang-Xi et. al.
Facile and efficient approach for the synthesis of N 2-dimethylaminomethylene-2′- O-methylguanosine
score: 1.9461391, Bioorganic & Medicinal Chemistry Letters, 2010, Mukobata, Tsuyoshi et. al.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 1.946049, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries
score: 1.9455202, Bioorganic & Medicinal Chemistry Letters, 2010, Buller, Fabian et. al.
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
score: 1.9448577, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
score: 1.9448577, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
Identification of novel inhibitors of bacterial translation elongation factors.
score: 1.9446511, Antimicrobial agents and chemotherapy, 2005, Jayasekera, Maithri M K et. al.
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
score: 1.9443472, Bioorganic & Medicinal Chemistry Letters, 2012, Verma, Vishal A. et. al.
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
score: 1.9443472, Bioorganic & Medicinal Chemistry Letters, 2012, Verma, Vishal A. et. al.
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
score: 1.9443472, Bioorganic & Medicinal Chemistry Letters, 2012, Verma, Vishal A. et. al.
Synthesis and in vitro antitumor activity of novel series 2-benzylthio-4-chlorobenzenesulfonamide derivatives
score: 1.9443062, European Journal of Medicinal Chemistry, 2006, Sławiński, J.; Brzozowski, Z.
Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs
score: 1.9442995, Bioorganic & Medicinal Chemistry Letters, 2013, Xu, Libo et. al.
Development of prostaglandin D 2 receptor antagonist: discovery of highly potent antagonists
score: 1.9437493, Bioorganic & Medicinal Chemistry, 2004, Torisu, Kazuhiko et. al.
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode
score: 1.9436699, Bioorganic & Medicinal Chemistry Letters, 2006, von Geldern, Thomas W. et. al.
Chlamydocin–hydroxamic acid analogues as histone deacetylase inhibitors
score: 1.9436236, Bioorganic & Medicinal Chemistry, 2004, Nishino, Norikazu et. al.
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives
score: 1.9435085, Bioorganic & Medicinal Chemistry Letters, 2012, Akué-Gédu, Rufine et. al.
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives
score: 1.9435085, Bioorganic & Medicinal Chemistry Letters, 2012, Akué-Gédu, Rufine et. al.
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives
score: 1.9435085, Bioorganic & Medicinal Chemistry Letters, 2012, Akué-Gédu, Rufine et. al.
Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors
score: 1.9430335, Bioorganic & Medicinal Chemistry, 2005, Jin, Yi et. al.
Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives
score: 1.942843, European Journal of Medicinal Chemistry, 2012, Audisio, Davide et. al.
Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development
score: 1.9427493, Bioorganic & Medicinal Chemistry Letters, 2012, Raboisson, Patrick et. al.
Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development
score: 1.9427493, Bioorganic & Medicinal Chemistry Letters, 2012, Raboisson, Patrick et. al.
Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of type 3 17β-hydroxysteroid dehydrogenase
score: 1.9426037, Bioorganic & Medicinal Chemistry, 2001, Maltais, René; Luu-The, Van; Poirier, Donald
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis.
score: 1.9424336, Antimicrobial agents and chemotherapy, 2010, Nare, Bakela et. al.
An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines
score: 1.9423993, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines
score: 1.9423993, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
Concise and efficient asymmetric synthesis of ( S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ
score: 1.9421955, Bioorganic & Medicinal Chemistry Letters, 2006, Kasuga, Jun-ichi; Hashimoto, Yuichi; Miyachi, Hiroyuki
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
score: 1.9419899, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Junxing et. al.
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
score: 1.9419899, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Junxing et. al.
Docking and 3D-QSAR studies of 7-hydroxycoumarin derivatives as CK2 inhibitors
score: 1.9419816, European Journal of Medicinal Chemistry, 2010, Zhang, Na; Zhong, Rugang
Synthesis and structure–activity relationship for new series of 4-Phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase
score: 1.9419791, Bioorganic & Medicinal Chemistry, 2003, Kubo, Kazuo et. al.
Optically active antifungal azoles: synthesis and antifungal activity of (2 R,3 S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl}-tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol
score: 1.9419724, Bioorganic & Medicinal Chemistry, 2004, Upadhayaya, Ram Shankar et. al.
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 1.9418686, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds
score: 1.9408956, Bioorganic & Medicinal Chemistry Letters, 2012, Ortar, Giorgio et. al.
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds
score: 1.9408956, Bioorganic & Medicinal Chemistry Letters, 2012, Ortar, Giorgio et. al.
2-Aryl-8-chloro-1,2,4-triazolo[1,5- a]quinoxalin-4-amines as highly potent A 1 and A 3 adenosine receptor antagonists
score: 1.9405596, Bioorganic & Medicinal Chemistry, 2005, Catarzi, Daniela et. al.
Identification of a buried pocket for potent and selective inhibition of Chk1: Prediction and verification
score: 1.9403498, Bioorganic & Medicinal Chemistry, 2006, Foloppe, Nicolas et. al.
Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability
score: 1.9391233, Bioorganic & Medicinal Chemistry, 2004, Ano, Rieko et. al.
Phosphatase inhibitors—III. Benzylaminophosphonic acids as potent inhibitors of human prostatic acid phosphatase
score: 1.9391233, Bioorganic & Medicinal Chemistry, 1996, Beers, Scott A. et. al.
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
score: 1.9386943, Bioorganic & Medicinal Chemistry Letters, 2012, Oza, Vibha et. al.
Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents
score: 1.9385852, Bioorganic & Medicinal Chemistry Letters, 2012, Pandey, Rishi Ranjan et. al.
Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists
score: 1.9384637, Bioorganic & Medicinal Chemistry, 2012, Puleo, Letizia et. al.
Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein
score: 1.9381469, Bioorganic & Medicinal Chemistry, 2013, Peuchmaur, Marine et. al.
Structure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leads.
score: 1.9378642, Antimicrobial agents and chemotherapy, 2006, Joska, Tammy M; Anderson, Amy C
Chemistry and clinical biology of the bryostatins
score: 1.9374716, Bioorganic & Medicinal Chemistry, 2000, Mutter, Roger; Wills, Martin
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.9371891, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.9371891, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
Structure guided P1’ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s Disease
score: 1.937026, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.
score: 1.9368618, Nature chemical biology, 2012, Richter, Lars et. al.
4-Substituted boro-proline dipeptides: Synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities
score: 1.9367007, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Wengen et. al.
New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: Synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies
score: 1.9364273, European Journal of Medicinal Chemistry, 2012, Hanna, Mona M.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles
score: 1.936305, European Journal of Medicinal Chemistry, 2012, Peng, Wei et. al.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles
score: 1.936305, European Journal of Medicinal Chemistry, 2012, Peng, Wei et. al.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles
score: 1.936305, European Journal of Medicinal Chemistry, 2012, Peng, Wei et. al.
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation
score: 1.9362219, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yanhui; Voak, Andrew; Wilkinson, Shane R.; Hu, Longqin
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation
score: 1.9362219, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yanhui; Voak, Andrew; Wilkinson, Shane R.; Hu, Longqin
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
score: 1.9358579, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria
score: 1.9357364, Bioorganic & Medicinal Chemistry, 2012, Cherian, Philip T. et. al.
Synthesis and biological evaluation of new spin-labeled derivatives of podophyllotoxin
score: 1.9355908, Bioorganic & Medicinal Chemistry, 2006, Jin, Yan; Chen, Shi-Wu; Tian, Xuan
Design, synthesis and biological evaluation of 6-substituted carboxamido benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists
score: 1.9354494, Bioorganic & Medicinal Chemistry, 2012, Zhang, Jun et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 1.9353938, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay.
score: 1.9342502, Antimicrobial agents and chemotherapy, 2012, Yu, Xuemei et. al.
Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists
score: 1.934238, Bioorganic & Medicinal Chemistry, 2012, Zhang, Jun et. al.
Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation
score: 1.9340864, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation
score: 1.9340864, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Synthesis and structure activity relationship of guanidines as NPY Y5 antagonists
score: 1.9338385, Bioorganic & Medicinal Chemistry, 2004, Aquino, Christopher J et. al.
Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents
score: 1.9338279, Bioorganic & Medicinal Chemistry Letters, 2012, Husain, Asif et. al.
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV
score: 1.9335068, Bioorganic & Medicinal Chemistry Letters, 2012, Manchester, John I. et. al.
Insertion of an internal dipeptide into PNA oligomers: Thermal melting studies and further functionalization
score: 1.9334842, Bioorganic & Medicinal Chemistry Letters, 2006, Kersebohm, Tim; Kirin, Srec̀ko I.; Metzler-Nolte, Nils
Synthesis and structure–activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure
score: 1.9334522, Bioorganic & Medicinal Chemistry, 2005, Kuramochi, Takahiro et. al.
Fused Tricyclic Indoles as S1P1 Agonists with Robust Efficacy in Animal Models of Autoimmune Disease
score: 1.9334104, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel et. al.
Synthesis of alkenyldiarylmethane (ADAM) non-Nucleoside HIV-1 reverse transcriptase inhibitors with non-Identical aromatic rings
score: 1.9333652, Bioorganic & Medicinal Chemistry, 2002, Xu, Guozhang et. al.
Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors
score: 1.9332086, Bioorganic & Medicinal Chemistry, 2006, Zhang, Li; Zhang, Jie; Fang, Hao; Wang, Qiang; Xu, Wenfang
Synthesis of a novel tetrahydroisoquinolino[2,1- c][1,4]benzodiazepine ring system with DNA recognition potential
score: 1.9331356, Bioorganic & Medicinal Chemistry Letters, 2004, Kothakonda, Kiran Kumar; Bose, D. Subhas
Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors
score: 1.9329245, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Dong-Dong et. al.
A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes
score: 1.932847, Bioorganic & Medicinal Chemistry Letters, 2012, Graham, Thomas H. et. al.
Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors
score: 1.9325677, Bioorganic & Medicinal Chemistry Letters, 2013, Luo, Yin et. al.
High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3- c]quinolin-3-ones
score: 1.9323153, Bioorganic & Medicinal Chemistry, 2003, Carotti, Andrea et. al.
Synthesis and nematocide activity of S-glycopyranosyl-6,7-diarylthiolumazines
score: 1.9322723, Bioorganic & Medicinal Chemistry, 2004, Martins Alho, Miriam A et. al.
N-Acyl- N-alkyl-sulfonamide anchors derived from Kenner’s safety-catch linker: powerful tools in bioorganic and medicinal chemistry
score: 1.9321818, Bioorganic & Medicinal Chemistry, 2005, Heidler, Philipp; Link, Andreas
Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship
score: 1.9321773, Bioorganic & Medicinal Chemistry Letters, 2012, Kers, Inger et. al.
Design and synthesis of downsized metastin (45–54) analogs with maintenance of high GPR54 agonistic activity
score: 1.9320747, Bioorganic & Medicinal Chemistry Letters, 2006, Niida, Ayumu et. al.
Synthesis and antimicrobial activity of tetrodecamycin partial structures
score: 1.9316787, Bioorganic & Medicinal Chemistry, 2003, Paintner, Franz F et. al.
A brief tour of myxobacterial secondary metabolism
score: 1.9316182, Bioorganic & Medicinal Chemistry, 2009, Weissman, Kira J.; Müller, Rolf
Amino substituted derivatives of 5′-amino-5′-deoxy-5′-noraristeromycin
score: 1.931593, Bioorganic & Medicinal Chemistry, 2005, Yang, Minmin; Schneller, Stewart W.
Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists
score: 1.9313296, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Chuangxing et. al.
Towards a Kcc2 Blocker Pharmacophore Model
score: 1.9310868, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.931073, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents
score: 1.9309296, Bioorganic & Medicinal Chemistry, 1996, ter Haar, Ernst et. al.
Discovery of Novel Phosphonic Acid Derivatives as New Chemical Leads for Inhibitors of TNF-α production
score: 1.9308217, Bioorganic & Medicinal Chemistry, 2002, Matsui, Toshiaki et. al.
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors
score: 1.9305881, Bioorganic & Medicinal Chemistry Letters, 2012, Pechulis, Anthony D. et. al.
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors
score: 1.9305881, Bioorganic & Medicinal Chemistry Letters, 2012, Pechulis, Anthony D. et. al.
Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase
score: 1.9305646, Bioorganic & Medicinal Chemistry Letters, 2012, Heasley, Brian H. et. al.
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC
score: 1.9305388, Bioorganic & Medicinal Chemistry Letters, 2012, Warmus, Joseph S. et. al.
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies
score: 1.9301594, Bioorganic & Medicinal Chemistry Letters, 2012, Watanabe, Yoshikazu et. al.
Structure-Activity Relationships and Key Structural Feature of Pyridyloxybenzene-Acylsulfonamides as New, Potent, and Selective Peroxisome Proliferator-Activated Receptor (PPAR) γ Agonists
score: 1.9300873, Bioorganic & Medicinal Chemistry, 2012, Rikimaru, Kentaro et. al.
The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phenyl]-(3-methyl-but-2-enyl)-amine, an N-type Ca +2 channel blocker with oral activity for analgesia
score: 1.9299587, Bioorganic & Medicinal Chemistry, 2000, Hu, Lain-Yen et. al.
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors
score: 1.929727, Bioorganic & Medicinal Chemistry Letters, 2012, Le Brazidec, Jean-Yves et. al.
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors
score: 1.929727, Bioorganic & Medicinal Chemistry Letters, 2012, Le Brazidec, Jean-Yves et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors
score: 1.9296802, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors
score: 1.9296802, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L.
score: 1.9291457, Bioorganic & Medicinal Chemistry Letters, 2012, Sun, Jieyin et. al.
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
score: 1.9291094, Bioorganic & Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
score: 1.9291094, Bioorganic & Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
score: 1.9291094, Bioorganic & Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 1.9286597, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 1.9286597, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity
score: 1.9286348, Bioorganic & Medicinal Chemistry, 2006, Pudhom, Khanitha et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.9285955, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.9285955, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.9285758, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.9285758, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
QSAR studies on piperazinylalkylisoxazole analogues selectively acting on dopamine d 3 receptor by HQSAR and CoMFA
score: 1.9285092, Bioorganic & Medicinal Chemistry, 2003, Cha, Mi Young et. al.
Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling
score: 1.9283698, Bioorganic & Medicinal Chemistry, 2007, Shao, Xuan et. al.
New Substituted 4H-Chromenes as anti-cancer agents
score: 1.9281035, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
Synthesis and biological activity of 22-iodo- and ( E)-20(22)-dehydro analogues of 1α,25-dihydroxyvitamin D 3
score: 1.9277038, Bioorganic & Medicinal Chemistry, 1999, Sicinski, Rafal R.; DeLuca, Hector F.
Synthesis, antiproliferative, and vasorelaxing evaluations of coumarin α-methylene-γ-butyrolactones
score: 1.9273787, Bioorganic & Medicinal Chemistry, 2005, Chen, Yeh-Long et. al.
Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3- d]pyrimidines
score: 1.9272656, European Journal of Medicinal Chemistry, 2003, Donkor, Isaac O; Li, Hui; Queener, Sherry F
Discovery of novel dihydroimidazothiazole derivatives as p53–MDM2 protein–protein interaction inhibitors: Synthesis, biological evaluation and structure–activity relationships
score: 1.9270355, Bioorganic & Medicinal Chemistry Letters, 2012, Miyazaki, Masaki et. al.
Site-Selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings
score: 1.9264066, Bioorganic & Medicinal Chemistry Letters, 2006, Liu, Dan; Zhou, Jiang; Li, Huihui; Zheng, Bo; Yuan, Gu
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.9259968, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
score: 1.9255236, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
score: 1.9255236, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
score: 1.9255236, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives
score: 1.9254806, Bioorganic & Medicinal Chemistry, 2006, Zou, Hong Bin et. al.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.9251684, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.9251684, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.9251684, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 1.9251644, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
Identification of specific features of inhibition of PKCβII and its potential lead by shape-based virtual screening and molecular docking studies
score: 1.9246964, Bioorganic & Medicinal Chemistry Letters, 2012, Grewal, Baljinder K.; Elizabeth Sobhia, M.
Highly potent cell differentiation-inducing analogues of 1α,25-dihydroxyvitamin D 3: synthesis and biological activity of 2-methyl-1,25-dihydroxyvitamin D 3 with side-chain modifications
score: 1.9246566, Bioorganic & Medicinal Chemistry, 2001, Fujishima, Toshie et. al.
Synthesis and biological evaluation of 6-aryl-6 H-pyrrolo[3,4- d]pyridazine derivatives as high-affinity ligands of the α 2δ subunit of voltage-gated calcium channels
score: 1.924522, Bioorganic & Medicinal Chemistry Letters, 2004, Hu, Tao et. al.
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.9244274, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.9244274, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.9244274, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Investigation into the structure–activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists
score: 1.9243519, Bioorganic & Medicinal Chemistry, 2005, McCalmont, William F. et. al.
Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4- c]quinoline-1,3-diones
score: 1.9241499, European Journal of Medicinal Chemistry, 2005, Kravchenko, Dmitri V. et. al.
Novobiocin analogues with second-generation noviose surrogates
score: 1.9241077, Bioorganic & Medicinal Chemistry Letters, 2013, Zhao, Huiping; Blagg, Brian S.J.
Biscoumarin: new class of urease inhibitors; economical synthesis and activity
score: 1.9240349, Bioorganic & Medicinal Chemistry, 2004, Khan, Khalid Mohammed et. al.
Synthesis and characterization of 2’-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 1.9237272, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Oral delivery of G protein-coupled receptor modulators: An explanation for the observed class difference
score: 1.9234518, Bioorganic & Medicinal Chemistry Letters, 2005, Beaumont, Kevin; Schmid, Esther; Smith, Dennis A.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.9234003, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent
score: 1.923327, Bioorganic & Medicinal Chemistry, 2012, Walls, Thomas H. et. al.
Effect of alkyl chain length on sphingosine kinase 2 selectivity
score: 1.9230987, Bioorganic & Medicinal Chemistry Letters, 2012, Knott, Kenneth et. al.
Investigation of the incidence of “undesirable” molecular moieties for high-throughput screening compound libraries in marketed drug compounds
score: 1.9230382, European Journal of Medicinal Chemistry, 2009, Axerio-Cilies, Peter et. al.
Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent
score: 1.9222568, Bioorganic & Medicinal Chemistry Letters, 2012, Odan, Masahide et. al.
The 3-D QSAR study of anticancer 1- N-substituted imidazo- and pyrrolo-quinoline-4,9-dione derivatives by CoMFA and CoMSIA
score: 1.9220834, Bioorganic & Medicinal Chemistry, 2001, Suh, Myung-Eun; Kang, Min-Jung; Park, So-Young
Synthesis and evaluation of novel potent HCV NS5A inhibitors
score: 1.9218723, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hongwang et. al.
Synthesis and evaluation of novel potent HCV NS5A inhibitors
score: 1.9218723, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hongwang et. al.
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity
score: 1.921834, Bioorganic & Medicinal Chemistry Letters, 2012, Fisher, Matthew J. et. al.
Serendipity in discovery of proteasome inhibitors
score: 1.9218234, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Serendipity in discovery of proteasome inhibitors
score: 1.9218234, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Optimization of unique, uncharged thioesters as inhibitors of HIV replication
score: 1.9217806, Bioorganic & Medicinal Chemistry, 2004, Srivastava, Pratibha et. al.
E297G Mutated Bile Salt Export Pump (BSEP) Function Enhancers Derived from GW4064: Structural Development Study and Separation from Farnesoid X Receptor-Agonistic Activity
score: 1.9214702, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT 4 receptor antagonists
score: 1.9213088, Bioorganic & Medicinal Chemistry, 1999, López-Rodrı́guez, Marı́a L. et. al.
Design and Synthesis of Polyethylene Glycol-modified Biphenylsulfonyl-thiophene-carboxamidine Inhibitors of the Complement Component C1s
score: 1.9212261, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems
score: 1.920692, Bioorganic & Medicinal Chemistry Letters, 2007, Dang, Vinh et. al.
9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase 1
score: 1.9206413, Bioorganic & Medicinal Chemistry Letters, 2002, Brakta, Mohamed et. al.
Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor
score: 1.9205325, Bioorganic & Medicinal Chemistry Letters, 2012, Strachan, Jon-Paul et. al.
Antimalarial activity: A QSAR modeling using CODESSA PRO software
score: 1.9205089, Bioorganic & Medicinal Chemistry, 2006, Katritzky, Alan R. et. al.
Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazolidinones] as potent antifungal agents and crystal structure of spiro[3 H -indole-3,2′-thiazolidine]-3′(1,2,4-triazol-3-yl)-2,4′(1 H )-dione
score: 1.9203665, Bioorganic & Medicinal Chemistry, 2006, Dandia, Anshu et. al.
16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: Synthesis, biological evaluation and in silico probe of ligand–receptor interaction
score: 1.9200648, European Journal of Medicinal Chemistry, 2012, Hu, Hao et. al.
16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: Synthesis, biological evaluation and in silico probe of ligand–receptor interaction
score: 1.9200648, European Journal of Medicinal Chemistry, 2012, Hu, Hao et. al.
Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease
score: 1.9198178, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease
score: 1.9198178, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease
score: 1.9198178, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
The 3D-QSAR analysis of 4(3 H)-quinazolinone derivatives with dithiocarbamate side chains on thymidylate synthase
score: 1.9197823, Bioorganic & Medicinal Chemistry, 2006, Liu, Shiying et. al.
Design and synthesis of novel metalloproteinase inhibitors
score: 1.9196387, Bioorganic & Medicinal Chemistry, 2006, Nakatani, Shingo et. al.
From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
score: 1.9195864, Bioorganic & Medicinal Chemistry Letters, 2013, Futatsugi, Kentaro et. al.
Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1 H-benzimidazole bioisosteres
score: 1.919533, European Journal of Medicinal Chemistry, 2006, Navarrete-Vázquez, Gabriel et. al.
β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study
score: 1.9194626, Bioorganic & Medicinal Chemistry, 2006, Milhazes, Nuno et. al.
Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors
score: 1.9191244, Bioorganic & Medicinal Chemistry, 2006, Bouissane, L. et. al.
Synthesis of [12]aneN3–dipeptide conjugates as metal-free DNA nucleases
score: 1.9190588, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Zhi-Fen; Chen, Hua-Long; Zhang, Li-Jun; Lu, Zhong-Lin
Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection.
score: 1.9187772, Antimicrobial agents and chemotherapy, 2012, St-Pierre, Christian et. al.
Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors
score: 1.9186225, Bioorganic & Medicinal Chemistry, 2012, Zhan, Wenhu et. al.
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells
score: 1.9185526, Bioorganic & Medicinal Chemistry, 2012, Rennhack, Andreas et. al.
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells
score: 1.9185526, Bioorganic & Medicinal Chemistry, 2012, Rennhack, Andreas et. al.
Synthesis and pharmacological evaluationof 2,3-dihydro-3-oxo-4 H -thieno[3,4- e ][1,2,4]thiadiazine 1,1-dioxidesas voltage-dependent calcium channel blockers
score: 1.9185411, European Journal of Medicinal Chemistry, 2000, Arranz, Esther et. al.
Syntheses and Structure-activity Relationship Studies of N-Substituted-β-D-glucosaminides as Selective Cytotoxic Agents
score: 1.9177579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity
score: 1.9173192, Bioorganic & Medicinal Chemistry, 1999, Boyd, Steven A et. al.
Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone
score: 1.9172889, Bioorganic & Medicinal Chemistry, 2013, Szkaradek, Natalia et. al.
The oxetane conformational lock of paclitaxel: Structural analysis of D-secopaclitaxel
score: 1.9171211, Bioorganic & Medicinal Chemistry Letters, 1999, Boge, Thomas C. et. al.
Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: A lipophilic substitute role
score: 1.916962, Bioorganic & Medicinal Chemistry Letters, 2013, Lo, Chih-Yu et. al.
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent
score: 1.91672, Bioorganic & Medicinal Chemistry, 2005, Suzuki, Takayoshi et. al.
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones—Targeting virulence of uropathogenic E. coli
score: 1.9166825, Bioorganic & Medicinal Chemistry, 2006, Åberg, Veronica et. al.
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors
score: 1.9164011, Bioorganic & Medicinal Chemistry, 2012, Albrecht, Sébastien et. al.
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
score: 1.9163714, Bioorganic & Medicinal Chemistry Letters, 2012, Rice, Kenneth D. et. al.
Synthesis, spectral studies and in vitro assessment for antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones
score: 1.9161862, Bioorganic & Medicinal Chemistry Letters, 2005, Singh, Shailendra; Athar, Fareeda; Azam, Amir
Synthesis and antimycobacterial activities of ring-substituted quinolinecarboxylic acid/ester analogues. Part 1
score: 1.9158581, Bioorganic & Medicinal Chemistry, 2004, Vaitilingam, Balasubramanian et. al.
QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release
score: 1.9157532, Bioorganic & Medicinal Chemistry, 2006, Zheng, Fang et. al.
Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in vivo
score: 1.9156413, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Nian-Guang et. al.
Antimalarial activity of N 6-substituted adenosine derivatives. Part 3
score: 1.9154026, Bioorganic & Medicinal Chemistry, 2004, Herforth, Claudia et. al.
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2
score: 1.9153971, European Journal of Medicinal Chemistry, 2012, Galli, Ubaldina et. al.
Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors
score: 1.9151709, Bioorganic & Medicinal Chemistry, 2005, Tait, Annalisa et. al.
Discovery of Novel 5-(Ethyl or hydroxymethyl) Analogs of 2’-“Up” Fluoro (or hydroxyl) Pyrimidine Nucleosides as a New Class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium Inhibitors
score: 1.9150672, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs
score: 1.9148037, Bioorganic & Medicinal Chemistry, 2005, Bernier, Stéphane et. al.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.9147948, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 1.9147491, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 1.9147491, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 1.9147491, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
A novel structural class of potent inhibitors of NF-κB activation: structure–activity relationships and biological effects of 6-aminoquinazoline derivatives
score: 1.9146842, Bioorganic & Medicinal Chemistry, 2003, Tobe, Masanori et. al.
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
score: 1.914523, Bioorganic & Medicinal Chemistry Letters, 2012, Rice, Kenneth D. et. al.
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 1.9143688, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Constructing plasma protein binding model based on a combination of cluster analysis and 4D-fingerprint molecular similarity analyses
score: 1.9143657, Bioorganic & Medicinal Chemistry, 2006, Liu, Jianzhong et. al.
Synthesis and evaluation of 2-amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine esters as potential prodrugs of acyclovir
score: 1.9143027, Bioorganic & Medicinal Chemistry, 1998, Kim, Dae-Kee et. al.
Discovery of Pyrazole Carboxylic Acids as Potent Inhibitors of Rat Long Chain L-2-Hydroxy Acid Oxidase
score: 1.9142905, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents
score: 1.9142805, European Journal of Medicinal Chemistry, 2013, Azizmohammadi, Mohammad et. al.
Synthesis and in vitro evaluation of 1,8-diazaanthraquinones bearing 3-dialkylaminomethyl or 3-( N-alkyl- or N-aryl)carbamoyloxymethyl substituent
score: 1.9142481, European Journal of Medicinal Chemistry, 2003, Lee, Heesoon et. al.
Glabracins A and B, two new acetogenins from Annona glabra
score: 1.9141176, Bioorganic & Medicinal Chemistry, 1998, Liu, Xiao-Xi et. al.
Potent inhibitors of CDK5 derived from roscovitine: Synthesis, biological evaluation and molecular modelling
score: 1.9136382, Bioorganic & Medicinal Chemistry Letters, 2013, Demange, Luc et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphospate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 1.9134506, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Substituted acrylophenones and related mannich bases as possible spermicides and inhibitors of HIV envelope glycoprotein–CD4 interaction
score: 1.9130035, European Journal of Medicinal Chemistry, 2002, Kumaria, Niharika et. al.
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists
score: 1.9129037, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4
score: 1.9128627, Bioorganic & Medicinal Chemistry, 2012, Lemonnier, Gérald et. al.
Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes
score: 1.9122583, Bioorganic & Medicinal Chemistry, 2005, Welch, Karen T. et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 1.912255, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/ unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.911995, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors
score: 1.9119292, European Journal of Medicinal Chemistry, 2013, Desideri, Nicoletta et. al.
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors
score: 1.9119292, European Journal of Medicinal Chemistry, 2013, Desideri, Nicoletta et. al.
Kappa agonist CovX-Bodies
score: 1.9117574, Bioorganic & Medicinal Chemistry Letters, 2012, Roberts, Lee R. et. al.
Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity
score: 1.9115227, Bioorganic & Medicinal Chemistry Letters, 2012, Dudkin, Vadim Y. et. al.
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds
score: 1.910988, Bioorganic & Medicinal Chemistry Letters, 2012, Ortar, Giorgio et. al.
Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
score: 1.9109481, Bioorganic & Medicinal Chemistry Letters, 2012, Khan, Mohammad Faheem et. al.
Pyrazolo-[1,5- a]-1,3,5-triazine corticotropin-Releasing factor (CRF) receptor ligands
score: 1.9106709, Bioorganic & Medicinal Chemistry, 2003, Gilligan, Paul J et. al.
α,α-Difluoro-β-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B
score: 1.9106155, Bioorganic & Medicinal Chemistry Letters, 2004, Li, Xianfeng et. al.
Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: Comparison with two original compounds, OL-92 and JP104
score: 1.9105326, Bioorganic & Medicinal Chemistry Letters, 2006, Michaux, Catherine et. al.
Simple Isoquinoline and Benzylisoquinoline Alkaloids as Potential Antimicrobial, Antimalarial, Cytotoxic, and Anti-HIV Agents
score: 1.9101232, Bioorganic & Medicinal Chemistry, 2001, Iwasa, Kinuko et. al.
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
score: 1.910002, Bioorganic & Medicinal Chemistry, 2005, Zheng, Guangrong et. al.
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I
score: 1.9099724, Bioorganic & Medicinal Chemistry Letters, 2012, Valeur, Eric et. al.
In vitro evaluation of synthetic heparin-like conjugates comprising different thrombin binding domains
score: 1.9099392, Bioorganic & Medicinal Chemistry Letters, 1998, Basten, J.E.M. et. al.
Synthesis of functionalized biphenyl- C-nucleosides and their incorporation into oligodeoxynucleotides
score: 1.909701, Bioorganic & Medicinal Chemistry, 2006, Zahn, Alain; Leumann, Christian J.
Highly potent inhibitors of TNF-α production. Part I
score: 1.909656, Bioorganic & Medicinal Chemistry, 2002, Matsui, Toshiaki et. al.
Synthesis of Novel Analogues of Marine Indole Alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and Bis(indolyl)-4-trifluoromethylpyridines as Potential Anticancer Agents
score: 1.9094858, Bioorganic & Medicinal Chemistry, 2001, Xiong, Wen-Nan; Yang, Cai-Guang; Jiang, Biao
Novel estrogen receptor (ER) modulators: Carbamate and thiocarbamate derivatives with m-carborane bisphenol structure
score: 1.9094332, Bioorganic & Medicinal Chemistry, 2009, Ohta, Kiminori et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.9093684, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di- O-(−)-camphanoyl-(+)- cis-khellactone (7-thia-DCK) analogs
score: 1.9087351, Bioorganic & Medicinal Chemistry, 2004, Chen, Ying et. al.
Doing the methylene shuffle – further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine
score: 1.9069747, European Journal of Medicinal Chemistry, 2012, Abualhasan, Murad N. et. al.
Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA
score: 1.9069158, Bioorganic & Medicinal Chemistry Letters, 2004, Maddaford, Shawn P. et. al.
Discovery and Evaluation of Selective N-type Calcium Channel Blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic Acid Derivatives
score: 1.9066946, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
score: 1.9064492, Bioorganic & Medicinal Chemistry Letters, 2000, Kappe, C.Oliver
Synthesis of chemoreversible prodrugs of ara-C with variable time-release profiles. Biological evaluation of their apoptotic activity
score: 1.9062036, Bioorganic & Medicinal Chemistry, 1996, Wipf, Peter et. al.
Further optimization of sulfonamide analogs as EP1 receptor antagonists: Synthesis and evaluation of bioisosteres for the carboxylic acid group
score: 1.9059861, Bioorganic & Medicinal Chemistry, 2006, Naganawa, Atsushi et. al.
Explorations into modeling human oral bioavailability
score: 1.9059849, European Journal of Medicinal Chemistry, 2008, Wang, Zhi; Yan, Aixia; Yuan, Qipeng; Gasteiger, Johann
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold
score: 1.9050967, Bioorganic & Medicinal Chemistry, 2006, Yue, Eddy W. et. al.
Ago-allosteric modulators of human glucagon-like peptide 2 receptor
score: 1.9049514, Bioorganic & Medicinal Chemistry Letters, 2012, Yamazaki, Kazuto et. al.
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists
score: 1.9048781, Bioorganic & Medicinal Chemistry Letters, 2012, Cameron, Kimberly O. et. al.
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists
score: 1.9047112, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists
score: 1.9047112, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
Microwave enhanced solid support synthesis of fluorine containing benzopyrano-triazolo-thiadiazepines as potent anti-fungal agents
score: 1.9046014, Bioorganic & Medicinal Chemistry, 2006, Dandia, Anshu; Singh, Ruby; Khaturia, Sarita
Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor
score: 1.9043514, Bioorganic & Medicinal Chemistry Letters, 2012, Strachan, Jon-Paul et. al.
Synthesis and MEK1 inhibitory activities of imido-Substituted 2-chloro-1,4-naphthoquinones
score: 1.904255, Bioorganic & Medicinal Chemistry, 2003, Bakare, Oladapo et. al.
Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors
score: 1.9041835, Bioorganic & Medicinal Chemistry Letters, 2012, Agarwal, Hitesh K. et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 1.9040488, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
Preparation and antioxidant activity of α-pyridoin and its derivatives
score: 1.9037747, Bioorganic & Medicinal Chemistry, 2005, Hatanaka, Masashi et. al.
An improved synthesis of 5′-fluoro-5′-deoxyadenosines
score: 1.9036923, Bioorganic & Medicinal Chemistry Letters, 2005, Ashton, Trent D.; Scammells, Peter J.
High throughput purification of combinatorial libraries
score: 1.9034303, Bioorganic & Medicinal Chemistry Letters, 1998, Schultz, Lauri et. al.
Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl)thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic
score: 1.9032799, Bioorganic & Medicinal Chemistry Letters, 2012, Popsavin, Mirjana et. al.
Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl)thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic
score: 1.9032799, Bioorganic & Medicinal Chemistry Letters, 2012, Popsavin, Mirjana et. al.
Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
score: 1.9031149, Bioorganic & Medicinal Chemistry Letters, 2012, Midtkandal, Rebecca R. et. al.
Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
score: 1.9024376, Bioorganic & Medicinal Chemistry, 2012, Yoshida, Tomohiro et. al.
N-Substituted amino acid N′-benzylamides: synthesis, anticonvulsant, and metabolic activities
score: 1.902431, Bioorganic & Medicinal Chemistry, 2004, Béguin, Cécile et. al.
Apoptosis-inducing effect of epolactaene derivatives on BALL-1 cells
score: 1.9011765, Bioorganic & Medicinal Chemistry, 2006, Kuramochi, Kouji et. al.
Synthesis and structure–activity relationships of fibrate-based analogues inside PPARs
score: 1.9011364, Bioorganic & Medicinal Chemistry Letters, 2012, Giampietro, Letizia et. al.
Spirohydantoin derivatives of thiopyrano[2,3- b]pyridin-4(4 H)-one as potent in vitro and in vivo aldose reductase inhibitors
score: 1.9008475, Bioorganic & Medicinal Chemistry, 2005, Da Settimo, Federico et. al.
Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives
score: 1.9008187, Bioorganic & Medicinal Chemistry, 2006, Sondhi, Sham M.; Dinodia, Monica; Kumar, Ashok
Syntheses of quinolone hydrochloride enantiomers from synthons ( R)- and ( S)-2-methylpiperazine
score: 1.9006761, Bioorganic & Medicinal Chemistry, 2005, Liu, Bo et. al.
Synthesis and structure–activity relationships of a series of pyrrole cannabinoid receptor agonists
score: 1.9000853, Bioorganic & Medicinal Chemistry, 2003, Tarzia, Giorgio et. al.
Fancy bioisosteres: Synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands
score: 1.8998979, Bioorganic & Medicinal Chemistry, 2005, Lenz, Carola et. al.
Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE
score: 1.8996903, Bioorganic & Medicinal Chemistry, 2001, Yang, Zhixiang et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.899672, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.899672, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.899672, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Synthesis of a novel plant growth promoter from gallic acid
score: 1.8993506, Bioorganic & Medicinal Chemistry Letters, 2005, Negi, Arvind Singh et. al.
Novel glycine transporter type-2 reuptake inhibitors. Part 1: α-amino acid derivatives
score: 1.898836, Bioorganic & Medicinal Chemistry, 2004, Wolin, Ronald L et. al.
design and synthesis of a novel series of HIV-1 protease inhibitors
score: 1.8984202, Bioorganic & Medicinal Chemistry, 1999, Takashiro, Eiji et. al.
Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines
score: 1.898228, Bioorganic & Medicinal Chemistry, 2012, Kouznetsov, Vladimir V. et. al.
Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines
score: 1.898228, Bioorganic & Medicinal Chemistry, 2012, Kouznetsov, Vladimir V. et. al.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8975807, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8975807, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8975807, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.8975459, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.8975459, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.8975459, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
A translation inhibitor that suppresses dengue virus in vitro and in vivo.
score: 1.8974248, Antimicrobial agents and chemotherapy, 2011, Wang, Qing-Yin et. al.
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates
score: 1.8974138, Bioorganic & Medicinal Chemistry, 2000, Kuang, Rongze et. al.
Structure-activity study of estrogenic agonists bearing dicarba- closo-dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules
score: 1.8969172, Bioorganic & Medicinal Chemistry Letters, 1999, Endo, Yasuyuki et. al.
Discovery of P2X3 selective antagonists for the treatment of chronic pain
score: 1.8967041, Bioorganic & Medicinal Chemistry Letters, 2012, Cantin, Louis-David et. al.
Synthesis and in vitro evaluation of α-synuclein ligands
score: 1.8966983, Bioorganic & Medicinal Chemistry, 2012, Yu, Lihai et. al.
3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity
score: 1.8965993, Bioorganic & Medicinal Chemistry, 2006, Athri, Prashanth et. al.
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement
score: 1.8958459, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Antitumor agents—CLXXIII. Synthesis and evaluation of camptothecin-4β-amino-4′- O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents
score: 1.8957778, Bioorganic & Medicinal Chemistry, 1997, Bastow, Kenneth F. et. al.
Antitumor agents—CLXXIII. Synthesis and evaluation of camptothecin-4β-amino-4′- O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents
score: 1.8957778, Bioorganic & Medicinal Chemistry, 1997, Bastow, Kenneth F. et. al.
Sesquiterpene-like inhibitors of a 9- cis-epoxycarotenoid dioxygenase regulating abscisic acid biosynthesis in higher plants
score: 1.8955812, Bioorganic & Medicinal Chemistry, 2009, Boyd, Jason et. al.
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
score: 1.8954948, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Hermogenes N. et. al.
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
score: 1.8954948, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Hermogenes N. et. al.
ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors
score: 1.8951893, Bioorganic & Medicinal Chemistry, 2012, Scholz, Matthias et. al.
ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors
score: 1.8951893, Bioorganic & Medicinal Chemistry, 2012, Scholz, Matthias et. al.
3D-QSAR study of ring-substituted quinoline class of anti-tuberculosis agents
score: 1.8951076, Bioorganic & Medicinal Chemistry, 2006, Nayyar, Amit et. al.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.8948584, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.8948584, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8947481, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Synthesis and anti-tubercular activity of a series of 2-sulfonamido/trifluoromethyl-6-substituted imidazo[2,1- b]-1,3,4-thiadiazole derivatives
score: 1.8945596, Bioorganic & Medicinal Chemistry, 2004, Gadad, Andanappa K. et. al.
Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden
score: 1.8944231, Bioorganic & Medicinal Chemistry, 2009, Muehlebach, Michel et. al.
Facile synthesis of non-steroidal anti-inflammatory active bisbenzamide-containing compounds
score: 1.8939024, Bioorganic & Medicinal Chemistry, 2006, Girgis, Adel S.; Ellithey, Mohey
Natural products-based insecticidal agents 4. Semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against Mythimna separata Walker in vivo
score: 1.8938653, Bioorganic & Medicinal Chemistry Letters, 2009, Xu, Hui; Xiao, Xiao
Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation
score: 1.893405, European Journal of Medicinal Chemistry, 2012, Abdou, Wafaa M.; Barghash, Reham F.; Sediek, Ashraf A.
Beyond physical properties—Application of Abraham descriptors and LFER analysis in agrochemical research
score: 1.8932101, Bioorganic & Medicinal Chemistry, 2009, Clarke, Eric D
Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls
score: 1.892908, Bioorganic & Medicinal Chemistry, 2012, De Schutter, Joris W. et. al.
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers
score: 1.8929, Bioorganic & Medicinal Chemistry, 2005, Mehanna, Ahmed S.; Kim, Jin Yung
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
score: 1.8926961, European Journal of Medicinal Chemistry, 2012, Zhang, Zhili et. al.
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
score: 1.8926961, European Journal of Medicinal Chemistry, 2012, Zhang, Zhili et. al.
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
score: 1.8926961, European Journal of Medicinal Chemistry, 2012, Zhang, Zhli et. al.
Bile acid-based receptors containing 2,6-bis(acylamino)pyridine for recognition of uracil derivatives
score: 1.8923443, Bioorganic & Medicinal Chemistry Letters, 2007, Chattopadhyay, Prosenjit; Pandey, Pramod S.
Naphthyridinone (NTD) integrase inhibitors: N1 Protio and methyl combination substituent effects with C3 amide groups
score: 1.8923244, Bioorganic & Medicinal Chemistry Letters, 2013, Johns, Brian A. et. al.
Serendipity in Discovery of Proteasome Inhibitors
score: 1.8922655, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors
score: 1.8920759, European Journal of Medicinal Chemistry, 2005, Shen, Qiong et. al.
Synthesis and evaluation of a new series of 1′-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4′-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists
score: 1.8920558, Bioorganic & Medicinal Chemistry Letters, 2012, Dandu, Reddeppa Reddy et. al.
D-ring modified novel isosteviol derivatives: Design, synthesis and cytotoxic activity evaluation
score: 1.8920175, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Tao et. al.
Short pseudopeptides containing turn scaffolds with high AT 2 receptor affinity
score: 1.8918437, Bioorganic & Medicinal Chemistry, 2006, Georgsson, Jennie et. al.
Discovery of oxazole-based PDE4 inhibitors with picomolar potency
score: 1.8914192, Bioorganic & Medicinal Chemistry Letters, 2012, Kuang, Rongze et. al.
Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase.
score: 1.8913286, Antimicrobial agents and chemotherapy, 2004, Ling, Losee L et. al.
Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents
score: 1.8908808, Bioorganic & Medicinal Chemistry, 2012, El Ashry, El Sayed H. et. al.
Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents
score: 1.8908808, Bioorganic & Medicinal Chemistry, 2012, El Ashry, El Sayed H. et. al.
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: The hydrophobic side chain influences type A subtype selectivity
score: 1.8907766, Bioorganic & Medicinal Chemistry, 2012, Li, Yanwu et. al.
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: The hydrophobic side chain influences type A subtype selectivity
score: 1.8907766, Bioorganic & Medicinal Chemistry, 2012, Li, Yanwu et. al.
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands
score: 1.8907765, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands
score: 1.8907765, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Tetra substituted thiophenes as anti-inflammatory agents: Exploitation of analogue-based drug design
score: 1.8907187, Bioorganic & Medicinal Chemistry, 2005, Pillai, Ajay D. et. al.
Viridin analogs derived from steroidal building blocks
score: 1.8906896, Bioorganic & Medicinal Chemistry Letters, 2012, Viswanathan, Kishore et. al.
Viridin analogs derived from steroidal building blocks
score: 1.8906896, Bioorganic & Medicinal Chemistry Letters, 2012, Viswanathan, Kishore et. al.
Viridin analogs derived from steroidal building blocks
score: 1.8906896, Bioorganic & Medicinal Chemistry Letters, 2012, Viswanathan, Kishore et. al.
Atom, atom-type and total molecular linear indices as a promising approach for bioorganic and medicinal chemistry: theoretical and experimental assessment of a novel method for virtual screening and rational design of new lead anthelmintic
score: 1.8905601, Bioorganic & Medicinal Chemistry, 2005, Marrero-Ponce, Yovani et. al.
JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities
score: 1.8904401, Bioorganic & Medicinal Chemistry Letters, 2012, Chorvat, Robert J. et. al.
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and Pharmacokinetic evaluation
score: 1.8899213, Bioorganic & Medicinal Chemistry Letters, 2012, Banerjee, Abhisek et. al.
Design, synthesis and vasodilative activity of tanshinone IIA derivatives
score: 1.8887809, Bioorganic & Medicinal Chemistry Letters, 2012, Bi, Yue-Feng et. al.
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors ofmPGES-1: Use of a conformation-based hypothesis to facilitate compound design
score: 1.8887188, Bioorganic & Medicinal Chemistry Letters, 2013, Walker, Daniel P. et. al.
Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis
score: 1.8886811, Bioorganic & Medicinal Chemistry Letters, 2008, Brouwer, Arwin J. et. al.
Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca 2+ release from sarcoplasmic reticulum of mouse skeletal muscle
score: 1.888425, Bioorganic & Medicinal Chemistry, 2003, Hosoya, Takamitsu et. al.
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities
score: 1.8883927, European Journal of Medicinal Chemistry, 2012, Ye, Deju et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.8872832, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.8872832, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.8872832, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
Metabolic conversion of 24-methyl-Δ 25-cholesterol to 24-methylcholesterol in higher plants
score: 1.8867343, Bioorganic & Medicinal Chemistry, 2006, Takahashi, Kyoko et. al.
Structure–activity relationship study of beta-carboline derivatives as haspin kinase inhibitors
score: 1.8866191, Bioorganic & Medicinal Chemistry Letters, 2012, Cuny, Gregory D. et. al.
Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents
score: 1.8863279, Bioorganic & Medicinal Chemistry, 2005, Agarwal, Anu et. al.
Seven-membered cycloplatinated complexes as a new family of anticancer agents. X-ray characterization and preliminary biological studies
score: 1.8860309, European Journal of Medicinal Chemistry, 2012, Cortés, Roldán et. al.
Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity
score: 1.8857319, Bioorganic & Medicinal Chemistry, 2005, Kim, Eun Jin; Ko, Soo Y.
Ras inhibition via direct Ras binding—is there a path forward?
score: 1.8856937, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Weiru; Fang, Guowei; Rudolph, Joachim
Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8856832, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8856832, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8856832, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Synthesis and comparative evaluation of 4-oxa- and 4-aza-podophyllotoxins as antiproliferative microtubule destabilizing agents
score: 1.8856388, Bioorganic & Medicinal Chemistry Letters, 2012, Chernysheva, Natalia B. et. al.
Design and synthesis of triglyceride analogue biotinylated suicide inhibitors for directed molecular evolution of lipolytic enzymes
score: 1.8855184, Bioorganic & Medicinal Chemistry Letters, 2000, Deussen, H.-J; Danielsen, S; Breinholt, J; Borchert, T.V
Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)- N-phenylacetamide—a potential antileishmanial agent
score: 1.8853322, Bioorganic & Medicinal Chemistry, 2002, Sahu, Niranjan P. et. al.
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
score: 1.88512, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors
score: 1.8849022, Bioorganic & Medicinal Chemistry Letters, 2005, Shou, Xiaohong; Miledi, Ricardo; Chamberlin, A. Richard
Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents
score: 1.8847459, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tianwen et. al.
Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents
score: 1.8847459, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tianwen et. al.
Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents
score: 1.8847459, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tianwen et. al.
Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer’s disease
score: 1.8847114, Bioorganic & Medicinal Chemistry Letters, 2012, Watanabe, Hiroyuki et. al.
Syntheses of new substituted triazino tetrahydroisoquinolines and β-carbolines as novel antileishmanial agents 1 1 CDRI Communication No. 6459.
score: 1.8843169, European Journal of Medicinal Chemistry, 2006, Kumar, Arun et. al.
Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D2 partial agonists
score: 1.8837073, Bioorganic & Medicinal Chemistry Letters, 2013, Urbanek, Rebecca A. et. al.
Structure-based design and protein X-ray analysis of a protein kinase inhibitor
score: 1.8835342, Bioorganic & Medicinal Chemistry Letters, 2002, Furet, Pascal et. al.
Structural Modification of an Orally Active Thrombin Inhibitor, LB30057: Replacement of the D-Pocket-binding Naphthyl Moiety
score: 1.8835135, Bioorganic & Medicinal Chemistry, 1998, Lee, Koo et. al.
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1 H)-imines and 1,5,6,7-Tetrahydro-2 H-azepin-2-imines
score: 1.8832531, Bioorganic & Medicinal Chemistry, 2003, Kawanaka, Yasufumi et. al.
Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.8831427, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yu-Shun et. al.
Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.8831427, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yu-Shun et. al.
Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit
score: 1.8829771, Bioorganic & Medicinal Chemistry Letters, 2009, Damljanović, Ivan et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity
score: 1.8819752, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity
score: 1.8819752, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
Synthesis of a novel, recyclable, solid-Phase acylating reagent
score: 1.8817502, Bioorganic & Medicinal Chemistry Letters, 2002, Nicewonger, Robert B. et. al.
Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases
score: 1.8808386, Bioorganic & Medicinal Chemistry, 2002, Peng, Hairuo et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8805972, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives
score: 1.8804079, Bioorganic & Medicinal Chemistry, 2003, Kolokythas, George et. al.
Synthesis, molecular modelling and enzymatic evaluation of (±)3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors
score: 1.8802791, Bioorganic & Medicinal Chemistry, 2006, Gauthier, Marie P. et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8801123, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8801123, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8801123, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans
score: 1.8798536, Bioorganic & Medicinal Chemistry Letters, 2013, Sidhu, Preetpal S. et. al.
Comparative QSAR modeling of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas
score: 1.8797261, Bioorganic & Medicinal Chemistry Letters, 2006, Thomas Leonard, J.; Roy, Kunal
Design, synthesis and in vitro evaluation of ( R)-4-(2-( tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl hydrogen phenylboronate: A novel salbutamol derivative with high intrinsic efficacy on the β 2 adrenoceptor
score: 1.8791263, Bioorganic & Medicinal Chemistry Letters, 2010, Soriano-Ursúa, Marvin A. et. al.
Synthesis of some monocyclic analogues of mycophenolic acid via the Johnson ortho ester Claisen rearrangement
score: 1.878978, Bioorganic & Medicinal Chemistry, 2005, Meza-Aviña, Ma Elena et. al.
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
score: 1.8774125, Bioorganic & Medicinal Chemistry Letters, 2012, Amombo, Ghislaine Marlyse Okala et. al.
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
score: 1.8774125, Bioorganic & Medicinal Chemistry Letters, 2012, Amombo, Ghislaine Marlyse Okala et. al.
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
score: 1.8774125, Bioorganic & Medicinal Chemistry Letters, 2012, Amombo, Ghislaine Marlyse Okala et. al.
“Propylene spaced” allyl tin reagents: A new class of fluorous tin reagents for allylations under radical and metal-catalyzed conditions
score: 1.8773922, Bioorganic & Medicinal Chemistry Letters, 1998, Curran, Dennis P.; Luo, Zhiyong; Degenkolb, Peter
An expedient synthesis of N 6-substituted-5′-modified adenosines
score: 1.8767276, Bioorganic & Medicinal Chemistry Letters, 2006, Ashton, T.D.; Scammells, Peter J.
Molecular modeling of the dopamine D 2 and serotonin 5-HT 1A receptor binding modes of the enantiomers of 5-OMe-BPAT
score: 1.8766695, Bioorganic & Medicinal Chemistry, 1999, Homan, Evert J.; Wikström, Håkan V.; Grol, Cor J.
Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors
score: 1.8766446, Bioorganic & Medicinal Chemistry, 2006, Liu, Yan et. al.
Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity
score: 1.8764217, European Journal of Medicinal Chemistry, 2013, Arya, Surbhi; Kumar, Nikhil; Roy, Partha; Sondhi, S.M.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.87579, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.87579, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.8756953, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype
score: 1.8753481, Bioorganic & Medicinal Chemistry, 2012, Calugi, Chiara et. al.
Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype
score: 1.8753481, Bioorganic & Medicinal Chemistry, 2012, Calugi, Chiara et. al.
Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
score: 1.8753248, Bioorganic & Medicinal Chemistry Letters, 2012, Bussenius, Joerg et. al.
Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs
score: 1.8752506, Bioorganic & Medicinal Chemistry, 2005, Våbenø, Jon et. al.
Synthesis and biological evaluation of new tetrahydro-β-carbolines as inhibitors of the mitotic kinesin Eg5
score: 1.875238, Bioorganic & Medicinal Chemistry, 2005, Sunder-Plassmann, Nils et. al.
Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors
score: 1.8751921, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Aixia; Wang, Kai
Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors
score: 1.8751921, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Aixia; Wang, Kai
Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors
score: 1.8751921, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Aixia; Wang, Kai
Microwave-assisted, one-pot syntheses and fungicidal activity of polyfluorinated 2-benzylthiobenzothiazoles
score: 1.8749295, Bioorganic & Medicinal Chemistry, 2006, Huang, Wei; Yang, Guang-Fu
Solid-phase synthesis of pyrrolo[2,1- c] [1,4]benzodiazepine-5,11-diones
score: 1.8746782, Bioorganic & Medicinal Chemistry Letters, 2001, Kamal, Ahmed; Reddy, G.Suresh Kumar; Raghavan, Sadagopan
Synthesis and activity of 1 H-benzimidazole and 1 H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii
score: 1.874676, Bioorganic & Medicinal Chemistry, 2004, Kopańska (née Zastąpiło), Katarzyna et. al.
Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988
score: 1.8746152, Bioorganic & Medicinal Chemistry, 1996, Augelli-Szafran, Corinne E. et. al.
A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma
score: 1.8740191, Bioorganic & Medicinal Chemistry Letters, 2013, Long, Daniel D. et. al.
Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives
score: 1.8740186, Bioorganic & Medicinal Chemistry Letters, 2012, Serra, Silvia et. al.
An approach to heterobifunctional poly(ethyleneglycol) bioconjugates
score: 1.8740159, Bioorganic & Medicinal Chemistry Letters, 2005, Li, Jane et. al.
Synthesis and biological evaluation of substrate-Based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African Trypanosomiasis
score: 1.873766, Bioorganic & Medicinal Chemistry, 2003, Dardonville, Christophe et. al.
Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin
score: 1.8736618, European Journal of Medicinal Chemistry, 2012, Zhang, Shao-Lin et. al.
A novel two-step QSAR modeling work flow to predict selectivity and activity of HDAC inhibitors
score: 1.8734926, Bioorganic & Medicinal Chemistry Letters, 2013, Zhao, Lingling et. al.
Synthesis and biological evaluation of disubstituted N 6-cyclopentyladenine analogues
score: 1.8734844, Bioorganic & Medicinal Chemistry, 2004, de Ligt, Rianne A.F. et. al.
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation
score: 1.8733858, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier-Dit-Chabert, Jérémie et. al.
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation
score: 1.8733858, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier-Dit-Chabert, Jérémie et. al.
Kinetic model studies on the chemical ligation of oligonucleotides via hydrazone formation
score: 1.8732854, Bioorganic & Medicinal Chemistry Letters, 2005, Achilles, K.; Kiedrowski, G.v.
Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities
score: 1.8731993, Bioorganic & Medicinal Chemistry, 2005, Sondhi, Sham M. et. al.
Identification of 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl]- N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration
score: 1.8725216, Bioorganic & Medicinal Chemistry, 2006, Singh, Sunil Kumar et. al.
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
score: 1.8723625, Bioorganic & Medicinal Chemistry, 2012, Su, Xiangdong et. al.
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
score: 1.8723625, Bioorganic & Medicinal Chemistry, 2012, Su, Xiangdong et. al.
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
score: 1.8723625, Bioorganic & Medicinal Chemistry, 2012, Su, Xiangdong et. al.
Design, synthesis, and BK channel-opening activity of hexahydrodibenzazepinone derivatives
score: 1.8721577, Bioorganic & Medicinal Chemistry, 2006, Tashima, Toshihiko et. al.
Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs
score: 1.8718988, Bioorganic & Medicinal Chemistry, 2006, Marrero-Ponce, Yovani et. al.
On-resin macrocyclization of peptides via intramolecular S nAr reactions
score: 1.8718112, Bioorganic & Medicinal Chemistry Letters, 1999, Fotsch, Christopher et. al.
The design of potent hydrazones and disulfides as cathepsin S inhibitors
score: 1.8717106, Bioorganic & Medicinal Chemistry, 2003, Cywin, Charles L et. al.
Design, synthesis and structure–activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.8715, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Synthesis and antitumor activity of bicyclo[3.3.1]nonenol derivatives
score: 1.8707354, Bioorganic & Medicinal Chemistry, 2004, Geirsson, Jon K.F.; Jonsson, Stefan; Valgeirsson, Jon
Structure–activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells
score: 1.8706789, Bioorganic & Medicinal Chemistry, 2005, Gibson, Scott L. et. al.
Identification of Novel Drug-Resistant EGFR Mutant Inhibitors by In Silico Screening using Comprehensive Assessments of Protein Structures
score: 1.8706685, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8705999, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
Synthesis of 2-Deoxy-2-C-Alkylglucosides of myo-Inositol as possible inhibitors of a N-Deacetylase enzyme in the biosynthesis of mycothiol
score: 1.8703814, Bioorganic & Medicinal Chemistry Letters, 2003, Gammon, David W. et. al.
Design and synthesis of new antimalarial agents from 4-aminoquinoline
score: 1.8702057, Bioorganic & Medicinal Chemistry, 2005, Solomon, V. Raja et. al.
Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones
score: 1.8699337, Bioorganic & Medicinal Chemistry Letters, 2012, Ryu, Chung-Kyu; Kim, Aram; Im, Hyun Ah; Kim, Ji Young
A concise synthesis of photoactivatable 4-Aroyl- l-phenylalanines
score: 1.8698277, Bioorganic & Medicinal Chemistry Letters, 2000, Morera, Enrico; Ortar, Giorgio
Structure–Activity Relationships of 1β-Methyl-2-(5-phenylpyrrolidin-3-ylthio)carbapenems
score: 1.8696836, Bioorganic & Medicinal Chemistry, 2002, Sato, Hiroki et. al.
Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: A practical access via Pd/C–Cu catalysis
score: 1.8696634, Bioorganic & Medicinal Chemistry Letters, 2012, Gorja, Dhilli Rao et. al.
A Focused Small-Molecule Screen Identifies 14 Compounds with Distinct Effects on Toxoplasma gondii.
score: 1.8694006, Antimicrobial agents and chemotherapy, 2012, Kamau, Edwin T et. al.
Structure-Based design and discovery of novel inhibitors of protein tyrosine phosphatases
score: 1.8692834, Bioorganic & Medicinal Chemistry, 2003, Huang, Ping et. al.
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues
score: 1.8690853, Bioorganic & Medicinal Chemistry, 2012, Wauchope, Orrette R. et. al.
Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides
score: 1.8686802, Bioorganic & Medicinal Chemistry Letters, 2012, Asami, Taiji et. al.
Synthesis and in vitro leishmanicidal activity of 2-(1-methyl-5-nitro-1 H-imidazol-2-yl)-5-substituted-1,3,4-thiadiazole derivatives
score: 1.8684963, European Journal of Medicinal Chemistry, 2005, Foroumadi, Alireza et. al.
New triterpenoid saponins from Cacti and anti-type I allergy activity of saponins from cactus
score: 1.8684684, Bioorganic & Medicinal Chemistry Letters, 2012, Kakuta, Kazutaka et. al.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
score: 1.8681306, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
score: 1.8681306, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
score: 1.8681306, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase
score: 1.867932, Bioorganic & Medicinal Chemistry, 2012, Lohou, Elodie et. al.
Structure–activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism
score: 1.867567, Bioorganic & Medicinal Chemistry Letters, 2012, Bhondwe, Rahul S. et. al.
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
score: 1.8673535, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
score: 1.8673535, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity
score: 1.8673239, European Journal of Medicinal Chemistry, 2013, Arya, Surbhi; Kumar, Nikhil; Roy, Partha; Sondhi, S.M.
Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors
score: 1.8669339, Bioorganic & Medicinal Chemistry, 2012, Liu, Jia-Jia et. al.
Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4/ABCC4)
score: 1.8667499, Bioorganic & Medicinal Chemistry Letters, 2008, Ravna, Aina Westrheim; Sager, Georg
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
score: 1.8662807, Bioorganic & Medicinal Chemistry, 2012, Lang, Karen Luise et. al.
Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: Some structural aspects for aldose reductase inhibitory activity and selectivity
score: 1.8655894, Bioorganic & Medicinal Chemistry, 2013, Kotsampasakou, Eleni; Demopoulos, Vassilis J.
Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists
score: 1.8655744, Bioorganic & Medicinal Chemistry, 2006, Cai, Zhefeng et. al.
Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity.
score: 1.8653974, Antimicrobial agents and chemotherapy, 2006, Ponte-Sucre, Alicia et. al.
A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles
score: 1.8652009, European Journal of Medicinal Chemistry, 2012, Almansour, Abdulrahman I. et. al.
Antagonists of the myelin-associated glycoprotein: A new class of tetrasaccharide mimics
score: 1.8650715, Bioorganic & Medicinal Chemistry, 2006, Schwizer, Daniel et. al.
Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives
score: 1.8650229, European Journal of Medicinal Chemistry, 2006, Tan, J.-H. et. al.
Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity
score: 1.864997, European Journal of Medicinal Chemistry, 2013, Liu, Han-Wei et. al.
Water soluble prodrugs of the antitumor agent 3-[(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-one
score: 1.8643459, Bioorganic & Medicinal Chemistry, 2003, Nam, Nguyen-Hai et. al.
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides
score: 1.8642961, Bioorganic & Medicinal Chemistry Letters, 2012, McComas, Casey et. al.
Preparation, antibacterial evaluation and preliminary structure–activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives
score: 1.8642385, Bioorganic & Medicinal Chemistry Letters, 2012, Ouyang, Liang et. al.
Preparation, antibacterial evaluation and preliminary structure–activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives
score: 1.8642385, Bioorganic & Medicinal Chemistry Letters, 2012, Ouyang, Liang et. al.
Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives
score: 1.8641656, Bioorganic & Medicinal Chemistry Letters, 2012, Shelke, Sharad N. et. al.
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B
score: 1.8640987, Bioorganic & Medicinal Chemistry Letters, 2012, Van der Walt, Mietha M. et. al.
Pyrazole CCK 1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free–Wilson additivity
score: 1.8640503, Bioorganic & Medicinal Chemistry Letters, 2006, McClure, Kelly et. al.
2,7-Dihydro-3 H-pyridazino[5,4,3- kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation
score: 1.8639726, Bioorganic & Medicinal Chemistry, 2005, Stefańska, Barbara et. al.
Carbonic anhydrase inhibitors: Two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-α-dithienylethene derivatives
score: 1.8637081, Bioorganic & Medicinal Chemistry Letters, 2009, Vomasta, Daniel et. al.
Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety
score: 1.8636981, Bioorganic & Medicinal Chemistry, 2005, Seto, Masaki et. al.
DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives
score: 1.8634697, Bioorganic & Medicinal Chemistry Letters, 2004, Bürli, Roland W. et. al.
Synthesis of Pacidamycin Analogues via an Ugi-Multicomponent Reaction
score: 1.8633713, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
2-Amidino analogs of glycine–amiloride conjugates: Inhibitors of urokinase-type plasminogen activator
score: 1.8628448, Bioorganic & Medicinal Chemistry Letters, 2012, Massey, Archna P. et. al.
Diels–alder approach to tetralin-based constrained α-amino acid derivatives
score: 1.8627232, Bioorganic & Medicinal Chemistry Letters, 2000, Kotha, Sambasivarao; Ganesh, Thota; Ghosh, Arun Kumar
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator
score: 1.8626176, Bioorganic & Medicinal Chemistry Letters, 2012, Mattmann, Margrith E. et. al.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.8625316, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.8625316, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.8625316, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
Design, synthesis, spectral and biological evaluation of novel 1-allyl substituted 2,6-diphenylpiperidin-4-ones and its derivatives of oximes/oxime ethers
score: 1.8624786, Bioorganic & Medicinal Chemistry Letters, 2012, Narayanan, Kuppusamy et. al.
Design, synthesis, spectral and biological evaluation of novel 1-allyl substituted 2,6-diphenylpiperidin-4-ones and its derivatives of oximes/oxime ethers
score: 1.8624786, Bioorganic & Medicinal Chemistry Letters, 2012, Narayanan, Kuppusamy et. al.
Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position
score: 1.8624765, Bioorganic & Medicinal Chemistry, 2004, Ohno, Michihiro et. al.
Cytotoxic activities of novel hexahydroindolizino[8,7-b]indole derivatives prepared by 1,3-dipolar cycloaddition reactions of 3,4-dihydro-β-carboline ylides
score: 1.8624693, Bioorganic & Medicinal Chemistry, 2001, Bertrand, Martial et. al.
Genetic introduction of a diketone-containing amino acid into proteins
score: 1.8624551, Bioorganic & Medicinal Chemistry Letters, 2006, Zeng, Huaqiang; Xie, Jianming; Schultz, Peter G.
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
score: 1.862168, Bioorganic & Medicinal Chemistry, 2012, Aminake, Makoah N. et. al.
Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives
score: 1.8621276, Bioorganic & Medicinal Chemistry, 2005, Chiyanzu, Idan et. al.
Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b
score: 1.8619223, Bioorganic & Medicinal Chemistry, 2004, Garneau, Sylvie et. al.
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors
score: 1.8619048, Bioorganic & Medicinal Chemistry, 2006, Hayakawa, Masahiko et. al.
Doing the methylene shuffle – Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
score: 1.8619036, European Journal of Medicinal Chemistry, 2012, Abualhasan, Murad N. et. al.
Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds
score: 1.8616979, Bioorganic & Medicinal Chemistry, 2003, Delfourne, Evelyne et. al.
A comparative protease stability study of synthetic macrocyclic peptides that mimic two endocrine hormones
score: 1.8616486, Bioorganic & Medicinal Chemistry Letters, 2013, Ferrie, John J. et. al.
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth
score: 1.8615004, Bioorganic & Medicinal Chemistry Letters, 2012, Siiskonen, Antti et. al.
A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4- N-aryl-[1,4] diazepane ureas
score: 1.8611861, European Journal of Medicinal Chemistry, 2009, Afantitis, Antreas et. al.
Design and synthesis of 3-fluoro-2-oxo-3-phenylpropionic acid derivatives as potent inhibitors of 4-hydroxyphenylpyruvate dioxygenase from pig liver
score: 1.8611825, Bioorganic & Medicinal Chemistry, 1999, Ling, Tung-shen; Shiu, Shi; Yang, Ding-yah
Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloroimidazole embodied 4-azafluorenones via molecular hybridization approach
score: 1.861168, Bioorganic & Medicinal Chemistry Letters, 2012, Addla, Dinesh et. al.
Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloroimidazole embodied 4-azafluorenones via molecular hybridization approach
score: 1.861168, Bioorganic & Medicinal Chemistry Letters, 2012, Addla, Dinesh et. al.
Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloroimidazole embodied 4-azafluorenones via molecular hybridization approach
score: 1.861168, Bioorganic & Medicinal Chemistry Letters, 2012, Addla, Dinesh et. al.
Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element
score: 1.8610222, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element
score: 1.8610222, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element
score: 1.8610222, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Discovery of liver selective non-steroidal glucocorticoid receptor antagonist as novel antidiabetic agents
score: 1.8607054, Bioorganic & Medicinal Chemistry Letters, 2012, Shah, Kiran et. al.
Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists
score: 1.860111, Bioorganic & Medicinal Chemistry, 2012, Negoro, Kenji et. al.
Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists
score: 1.860111, Bioorganic & Medicinal Chemistry, 2012, Negoro, Kenji et. al.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry
score: 1.8599769, Bioorganic & Medicinal Chemistry, 2012, Lapinsky, David J.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry
score: 1.8599769, Bioorganic & Medicinal Chemistry, 2012, Lapinsky, David J.
Anthranilic acid derivatives: a new class of non-peptide CCK 1 receptor antagonists
score: 1.8599747, Bioorganic & Medicinal Chemistry, 2003, Varnavas, Antonio et. al.
Discovery of a novel melanin-concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.8598366, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B
score: 1.8597925, Bioorganic & Medicinal Chemistry Letters, 2012, Van der Walt, Mietha M. et. al.
Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction
score: 1.8595463, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Young B. et. al.
Synthetic study on the unique dimeric arylpiperazine: access to the minor contaminant of aripiprazole
score: 1.8591812, Bioorganic & Medicinal Chemistry Letters, 2003, Torisawa, Yasuhiro et. al.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
score: 1.8590122, European Journal of Medicinal Chemistry, 2012, Opsenica, Igor et. al.
Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28
score: 1.8583171, Bioorganic & Medicinal Chemistry, 2006, Hulshof, Janneke W. et. al.
Synthesis of daidzin analogues as potential agents for alcohol abuse
score: 1.8582607, Bioorganic & Medicinal Chemistry, 2003, Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines
score: 1.8580055, Bioorganic & Medicinal Chemistry Letters, 2005, Tucci, Fabio C. et. al.
Synthesis and biological evaluation of a technetium-99m(I)-tricarbonyl-labelled phenyltropane derivative
score: 1.8579354, Bioorganic & Medicinal Chemistry Letters, 2006, Kieffer, Davy M. et. al.
The evolution of synthetic oral drug properties
score: 1.8576053, Bioorganic & Medicinal Chemistry Letters, 2005, Proudfoot, John R.
Optimized N-phenyl- N′-(2-chloroethyl)ureas as potential antineoplastic agents: Synthesis and growth inhibition activity
score: 1.8571167, Bioorganic & Medicinal Chemistry, 2005, Moreau, Emmanuel et. al.
Synthesis and in vitro antiproliferative activity of platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane as ligands
score: 1.8562657, European Journal of Medicinal Chemistry, 2012, Sun, Yanyan et. al.
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
score: 1.8560311, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Mo et. al.
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease
score: 1.8560195, European Journal of Medicinal Chemistry, 2012, Hamulakova, Slavka et. al.
The synthesis of novel fluorescent purine analogues modified by azacrown ether at C6
score: 1.8560039, Bioorganic & Medicinal Chemistry Letters, 2010, Guo, Hai-Ming et. al.
Synthesis of 14C-radiolabeled oligonucleotides with a novel phosphoramidite reagent
score: 1.8556917, Bioorganic & Medicinal Chemistry Letters, 1998, Guzaev, Andrei et. al.
Synthesis and biological evaluation of lipophilic Ca 1a 2L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1
score: 1.8556904, Bioorganic & Medicinal Chemistry, 2005, El Oualid, Farid et. al.
Halogenated flavanones as potential apoptosis-inducing agents: synthesis and biological activity evaluation
score: 1.8555431, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1)
score: 1.8555174, Bioorganic & Medicinal Chemistry, 2012, Orchard, Alexandra et. al.
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1)
score: 1.8555174, Bioorganic & Medicinal Chemistry, 2012, Orchard, Alexandra et. al.
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit
score: 1.8549504, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Xianming et. al.
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit
score: 1.8549504, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Xianming et. al.
Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities.
score: 1.854456, Antimicrobial agents and chemotherapy, 2006, Karginov, Vladimir A et. al.
One pot synthesis of thiazolodihydropyrimidinones and evaluation of their anticancer activity
score: 1.8541558, European Journal of Medicinal Chemistry, 2004, Holla, B.Shivarama et. al.
Toward intrinsically fluorescent proteomimetics: Fluorescent probe response to alpha helix structure of poly-γ-benzyl- l-glutamate
score: 1.8538827, Bioorganic & Medicinal Chemistry Letters, 2006, Hutt, Kenji; Hernandez, Randy; Heagy, Michael D.
Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers
score: 1.8535755, Bioorganic & Medicinal Chemistry, 2005, Graulich, A. et. al.
A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
score: 1.8535009, European Journal of Medicinal Chemistry, 2012, Venkateswararao, Eeda et. al.
Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1 H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1 H-pyrazoles
score: 1.8531797, Bioorganic & Medicinal Chemistry, 2004, Menozzi, Giulia et. al.
Synthesis and biological relationships of 3′,6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents
score: 1.8531677, Bioorganic & Medicinal Chemistry, 2005, Lai, Ya-Yun et. al.
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
score: 1.8529017, Bioorganic & Medicinal Chemistry, 2012, Chosson, Elizabeth et. al.
Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl α-ketoamide derivatives containing pyridine moiety
score: 1.8528289, Bioorganic & Medicinal Chemistry, 2006, Shirasaki, Yoshihisa et. al.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
score: 1.8526704, Bioorganic & Medicinal Chemistry Letters, 2012, Tichenor, Mark S. et. al.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
score: 1.8526704, Bioorganic & Medicinal Chemistry Letters, 2012, Tichenor, Mark S. et. al.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
score: 1.8526704, Bioorganic & Medicinal Chemistry Letters, 2012, Tichenor, Mark S. et. al.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption
score: 1.8526065, Bioorganic & Medicinal Chemistry, 2012, Okaniwa, Masanori et. al.
Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa
score: 1.8523921, Bioorganic & Medicinal Chemistry, 1998, Hopp, D.Craig et. al.
Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists
score: 1.8521918, Bioorganic & Medicinal Chemistry Letters, 2012, Lainé, Dramane I. et. al.
Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists
score: 1.8521918, Bioorganic & Medicinal Chemistry Letters, 2012, Lainé, Dramane I. et. al.
Binding of 1-Benzopyran-4-one Derivatives to Aldose Reductase: A Free Energy Perturbation Study
score: 1.851979, Bioorganic & Medicinal Chemistry, 2002, Rastelli, Giulio et. al.
Design and synthesis of potent, orally active, inhibitors of carboxypeptidase U (TAFIa)
score: 1.8518383, Bioorganic & Medicinal Chemistry, 2004, Polla, Magnus O. et. al.
Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity
score: 1.8516957, Bioorganic & Medicinal Chemistry, 2012, Alam, Mohammad Sayed; Choi, Jung-Hyun; Lee, Dong-Ung
Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity
score: 1.8516957, Bioorganic & Medicinal Chemistry, 2012, Alam, Mohammad Sayed; Choi, Jung-Hyun; Lee, Dong-Ung
Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity
score: 1.8516957, Bioorganic & Medicinal Chemistry, 2012, Alam, Mohammad Sayed; Choi, Jung-Hyun; Lee, Dong-Ung
Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents
score: 1.8512264, Bioorganic & Medicinal Chemistry, 2004, Jones, Simon M et. al.
Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy
score: 1.8510056, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Ming et. al.
Structure–activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding
score: 1.8508559, Bioorganic & Medicinal Chemistry, 2004, Lee, Jeewoo et. al.
Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents
score: 1.8506222, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Qian et. al.
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.8504889, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.8504889, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.8504889, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current
score: 1.8502166, Bioorganic & Medicinal Chemistry, 2005, Novella Romanelli, Maria et. al.
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: Design, synthesis, and microbiological evaluation
score: 1.8502093, Bioorganic & Medicinal Chemistry, 2006, Schiaffella, Fausto et. al.
Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution
score: 1.8500603, Bioorganic & Medicinal Chemistry Letters, 2013, Zitko, Jan et. al.
Synthesis and biological evaluation of 6-substituted purine and 9-β- d-ribofuranosyl purine analogues
score: 1.849753, Bioorganic & Medicinal Chemistry, 2004, Wang, Jun-Feng et. al.
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments
score: 1.8497342, Bioorganic & Medicinal Chemistry, 2001, Casimiro-Garcia, Agustin et. al.
Cytotoxic palladium complexes of bioreductive quinoxaline N 1, N 4-dioxide prodrugs
score: 1.8496116, Bioorganic & Medicinal Chemistry, 2009, Urquiola, Carolina et. al.
Structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives
score: 1.8493931, Bioorganic & Medicinal Chemistry, 2005, Guan, Jian et. al.
Adamantyl N-benzylbenzamide: New series of depigmentation agents with tyrosinase inhibitory activity
score: 1.8490711, Bioorganic & Medicinal Chemistry Letters, 2012, Baek, Heung Soo et. al.
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators
score: 1.8490436, Bioorganic & Medicinal Chemistry Letters, 2012, Pettersson, Martin et. al.
Novel glycine transporter type-2 reuptake inhibitors. Part 2: β- and γ-amino acid derivatives
score: 1.8489557, Bioorganic & Medicinal Chemistry, 2004, Wolin, Ronald L et. al.
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1 H-cyclopenta[ b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors
score: 1.8487606, Bioorganic & Medicinal Chemistry, 2006, Rosini, Michela et. al.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
score: 1.8487494, Bioorganic & Medicinal Chemistry Letters, 2012, Wollinsky, Beate et. al.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
score: 1.8487494, Bioorganic & Medicinal Chemistry Letters, 2012, Wollinsky, Beate et. al.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
score: 1.8487494, Bioorganic & Medicinal Chemistry Letters, 2012, Wollinsky, Beate et. al.
Synthesis and comparative molecular field analysis (CoMFA) of argentatin B derivatives as growth inhibitors of human cancer cell lines
score: 1.8486367, Bioorganic & Medicinal Chemistry, 2006, Parra-Delgado, Hortensia et. al.
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
score: 1.8486189, Bioorganic & Medicinal Chemistry, 2006, DeMarco, Steven J. et. al.
Synthesis, cytotoxicity, and anti-inflammatory evaluation of 2-(furan-2-yl)-4-(phenoxy)quinoline derivatives. Part 4
score: 1.848325, Bioorganic & Medicinal Chemistry, 2006, Chen, Yeh-Long et. al.
In silico modeling of protein tyrosine phosphatase 1B inhibitors with cellular activity
score: 1.8481255, Bioorganic & Medicinal Chemistry Letters, 2006, Hu, Xin
Design, synthesis, and biological evaluation of novel 2-pyridinyl-[1,2,4]triazoles as inhibitors of transforming growth factor β1 type 1 receptor
score: 1.847857, Bioorganic & Medicinal Chemistry, 2004, Kim, Dae-Kee; Kim, Joonseop; Park, Hyun-Ju
Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents
score: 1.847802, Bioorganic & Medicinal Chemistry, 2003, Kumar, Ashok et. al.
Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors
score: 1.8476843, Bioorganic & Medicinal Chemistry, 2013, Toti, Kiran S. et. al.
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
score: 1.8476602, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Microwave-assisted synthesis of imidazoles: Reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines
score: 1.84743, Bioorganic & Medicinal Chemistry Letters, 2005, Samanta, Swapan K.; Kylänlahti, Irene; Yli-Kauhaluoma, Jari
Synthesis, structure and biological activity of copper(II) complexes of 4-(2-pyridylmethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione and 4-(2-pyridylethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione
score: 1.8471644, European Journal of Medicinal Chemistry, 2009, Singh, Amit P. et. al.
Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening
score: 1.8468122, Bioorganic & Medicinal Chemistry Letters, 2012, Liang, Guyan et. al.
Radiolytic transformation of rotenone with potential anti-adipogenic activity
score: 1.846618, Bioorganic & Medicinal Chemistry Letters, 2013, Park, Chul-Hong et. al.
Assessing the drug-likeness of lamellarins, a marine-derived natural product class with diverse oncological activities
score: 1.8463687, European Journal of Medicinal Chemistry, 2010, Chittchang, Montakarn et. al.
Selective and potent adenosine A3receptor antagonists by methoxyaryl substitution on theN-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
score: 1.8457264, European Journal of Medicinal Chemistry, 2013, Yaziji, Vicente et. al.
Novel (3,5-di- tert-butyl-2-hydroxy-phenylcarbamoyl)-alkanoic acids as potent antioxidants
score: 1.8455098, Bioorganic & Medicinal Chemistry Letters, 2004, Lodyato, Vladimir I et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides
score: 1.8452453, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties
score: 1.8451944, Bioorganic & Medicinal Chemistry Letters, 1998, Takahashi, Takashi et. al.
Identification of benzoxazole analogs as novel, S1P3 sparing S1P1 agonists
score: 1.8450431, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Identification of benzoxazole analogs as novel, S1P3 sparing S1P1 agonists
score: 1.8450431, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Identification of benzoxazole analogs as novel, S1P3 sparing S1P1 agonists
score: 1.8450431, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile
score: 1.8449635, Bioorganic & Medicinal Chemistry Letters, 2013, Tamura, Yuusuke et. al.
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues
score: 1.8448515, Bioorganic & Medicinal Chemistry, 2012, Wauchope, Orrette R. et. al.
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues
score: 1.8448515, Bioorganic & Medicinal Chemistry, 2012, Wauchope, Orrette R. et. al.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives
score: 1.8447975, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives
score: 1.8447975, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors
score: 1.8444814, Bioorganic & Medicinal Chemistry, 2006, Cossy, Janine et. al.
Investigations of linker structure on the potency of a series of bidentate protein tyrosine phosphatase inhibitors
score: 1.8443509, Bioorganic & Medicinal Chemistry, 2005, Xie, Jian; Seto, Christopher T.
Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs
score: 1.8441305, Bioorganic & Medicinal Chemistry, 2012, Niphakis, Micah J. et. al.
Three-dimensional quantitative structure–activity relationship studies on diverse structural classes of HIV-1 integrase inhibitors using CoMFA and CoMSIA
score: 1.8440899, European Journal of Medicinal Chemistry, 2006, Nunthaboot, Nadtanet et. al.
Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones
score: 1.8437367, Bioorganic & Medicinal Chemistry Letters, 2005, Foroumadi, Alireza et. al.
Macrolactonolides: A novel class of anti-inflammatory compounds
score: 1.8436787, Bioorganic & Medicinal Chemistry, 2013, Tomašković, Linda et. al.
Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques.
score: 1.8435868, Antimicrobial agents and chemotherapy, 2004, Hurdle, Julian Gregston et. al.
Potent histone deacetylase inhibitors: N-hydroxybenzamides with antitumor activities
score: 1.8433295, Bioorganic & Medicinal Chemistry, 2004, Maeda, Taishi et. al.
Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis
score: 1.8433005, Bioorganic & Medicinal Chemistry, 2012, Donald, Michael B. et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.8432604, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods
score: 1.8428133, Bioorganic & Medicinal Chemistry Letters, 2006, Aparna, V. et. al.
Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues
score: 1.8423926, Bioorganic & Medicinal Chemistry, 2002, Lima, Lı́dia M et. al.
Fluorine-substituted dihydrobicyclomycins: Synthesis and biochemical and biological properties
score: 1.842247, Bioorganic & Medicinal Chemistry, 2006, Park, Boon-Saeng; Widger, William; Kohn, Harold
Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives
score: 1.8422071, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives
score: 1.8422071, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives
score: 1.8422071, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Benzofuro[3,2- f][1]benzopyrans: A new class of antitubercular agents
score: 1.8420641, Bioorganic & Medicinal Chemistry, 2006, Prado, Soizic et. al.
Study on molecular mechanism and 3D-QSAR of influenza neuraminidase inhibitors
score: 1.841931, Bioorganic & Medicinal Chemistry, 2003, Yi, Xiang; Guo, Zongru; Chu, Feng Ming
Isomannide derivatives as new class of inhibitors for human kallikrein 7
score: 1.8415975, Bioorganic & Medicinal Chemistry Letters, 2012, Freitas, Renato F. et. al.
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production
score: 1.8411809, Bioorganic & Medicinal Chemistry, 2012, Lee, Bit et. al.
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production
score: 1.8411809, Bioorganic & Medicinal Chemistry, 2012, Lee, Bit et. al.
Design, synthesis, and activity of caffeoyl pyrrolidine derivatives as potential gelatinase inhibitors
score: 1.8411594, Bioorganic & Medicinal Chemistry, 2004, Li, Ya-Lin; Xu, Wen-Fang
Design and Synthesis of Potent Antagonists Containing Rigid Spirocyclic Privileged Structures for the CGRP Receptor
score: 1.8407958, Bioorganic & Medicinal Chemistry Letters, 2012, Chaturvedula, Prasad V. et. al.
Simple synthesis of carbon-11 labeled styryl dyes as new potential PET RNA-specific, living cell imaging probes
score: 1.8406708, European Journal of Medicinal Chemistry, 2009, Wang, Min et. al.
A rationale for the activity profile of benzenesulfonamide derivatives as cyclooxygenase (COX) inhibitors
score: 1.8406399, European Journal of Medicinal Chemistry, 2010, Sharma, Brij Kishore et. al.
Structure-based design of achiral, nonpeptidic hydroxybenzamide as a novel P2/P2′ replacement for the symmetry-based HIV protease inhibitors
score: 1.8406023, Bioorganic & Medicinal Chemistry, 1996, Randad, Ramnarayan S. et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
score: 1.8400344, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
score: 1.8400344, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
score: 1.8400344, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
score: 1.8399587, Bioorganic & Medicinal Chemistry, 2004, Gündisch, Daniela et. al.
Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives
score: 1.8394655, Bioorganic & Medicinal Chemistry, 2004, Koshio, Hiroyuki et. al.
Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors
score: 1.8390134, Bioorganic & Medicinal Chemistry Letters, 2013, Poondra, Rajamohan R. et. al.
Synthesis and biological evaluation of p-carborane bisphenols and their derivatives: Structure–activity relationship for estrogenic activity
score: 1.8388029, Bioorganic & Medicinal Chemistry, 2009, Ogawa, Takumi et. al.
Mechanism-based Design, Synthesis and Biological Studies of N5-Substituted Tetrahydrofolate Analogues as Inhibitors of Cobalamin-dependent Methionine Synthase and Potential Anticancer Agents
score: 1.8378499, European Journal of Medicinal Chemistry, 2012, Zhang, Zhli et. al.
Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.
score: 1.8378033, Antimicrobial agents and chemotherapy, 2002, Evers, David L et. al.
Substituted hexahydrobenzodipyrans as 5-HT 2A/2C receptor probes
score: 1.8374597, Bioorganic & Medicinal Chemistry, 2002, Whiteside, Michael S et. al.
Lysine–spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants
score: 1.8372107, Bioorganic & Medicinal Chemistry, 2005, Burns, Mark R. et. al.
Synthesis and evaluation of 2-Amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-Amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir
score: 1.8367577, Bioorganic & Medicinal Chemistry, 1999, Kim, Dae-Kee et. al.
Synthesis and in vitro study of 17β-[ N-ureylene- N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase
score: 1.836672, Bioorganic & Medicinal Chemistry, 1997, Lourdusamy, Mettilda et. al.
Design and synthesis of new orally active inhibitors of human neutrophil elastase
score: 1.8365987, Bioorganic & Medicinal Chemistry, 2001, Ohmoto, Kazuyuki et. al.
Inhibitors of apoptosis in testicular germ cells: Synthesis and biological evaluation of some novel IBTs bearing sulfonamide moiety
score: 1.8363202, European Journal of Medicinal Chemistry, 2013, Chandak, Navneet et. al.
Inhibitors of apoptosis in testicular germ cells: Synthesis and biological evaluation of some novel IBTs bearing sulfonamide moiety
score: 1.8363202, European Journal of Medicinal Chemistry, 2013, Chandak, Navneet et. al.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
score: 1.8360493, Bioorganic & Medicinal Chemistry, 2012, Chobanian, Harry R. et. al.
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity
score: 1.8359415, Bioorganic & Medicinal Chemistry, 2005, Brun, Marie-Priscille et. al.
Prodrugs for targeting hypoxic tissues: Regiospecific elimination of aspirin from reduced indolequinones
score: 1.8356784, Bioorganic & Medicinal Chemistry Letters, 1999, Jaffar, M et. al.
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[ i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents
score: 1.8353346, Bioorganic & Medicinal Chemistry, 2005, Zhu, Shejin et. al.
Solid- and solution-Phase synthesis of highly-Substituted-Pyrrolidine libraries
score: 1.8353318, Bioorganic & Medicinal Chemistry Letters, 2001, Steger, M; Hubschwerlen, C; Schmid, G
Small molecule tertiary amines as agonists of the nuclear hormone receptor rev-erbα
score: 1.8349576, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Youseung et. al.
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα
score: 1.8349576, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Youseung et. al.
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα
score: 1.8349576, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Youseung et. al.
Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
score: 1.8345664, Bioorganic & Medicinal Chemistry Letters, 2012, Srikanth Reddy, T. et. al.
Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
score: 1.8345664, Bioorganic & Medicinal Chemistry Letters, 2012, Srikanth Reddy, T. et. al.
Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
score: 1.8345664, Bioorganic & Medicinal Chemistry Letters, 2012, Srikanth Reddy, T. et. al.
The synthesis of symmetrical spermine conjugates using solid-phase chemistry
score: 1.8340825, Bioorganic & Medicinal Chemistry Letters, 1998, Page, Patrick et. al.
Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents
score: 1.8338857, Bioorganic & Medicinal Chemistry, 2001, Jiang, Biao; Yang, Cai-Guang; Xiong, Wen-Nan; Wang, Jun
Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates
score: 1.8336468, Bioorganic & Medicinal Chemistry Letters, 2006, Jiang, Xiong-Jie et. al.
Synthesis and antimycobacterial evaluation of certain fluoroquinolone derivatives
score: 1.8335332, Bioorganic & Medicinal Chemistry, 2005, Zhao, Yue-Ling et. al.
Design, synthesis, and evaluation of resveratrol derivatives as Aß1-42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8332191, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides
score: 1.8332044, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides
score: 1.8332044, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Doing the methylene shuffle – Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
score: 1.8331244, European Journal of Medicinal Chemistry, 2012, Abualhasan, Murad N. et. al.
Neuraminidase pharmacophore model derived from diverse classes of inhibitors
score: 1.8330059, Bioorganic & Medicinal Chemistry Letters, 2006, Zhang, Jian; Yu, KunQian; Zhu, Weiliang; Jiang, Hualiang
Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues
score: 1.8329925, Bioorganic & Medicinal Chemistry, 2001, Kim, Dae-Kee et. al.
iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3( R)-[(2( S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide
score: 1.8326799, Bioorganic & Medicinal Chemistry, 2003, Dolbeare, Kristine et. al.
Synthesis of new phorbol derivatives having ethereal side chain and evaluation of their anti-HIV activity
score: 1.8324753, Bioorganic & Medicinal Chemistry, 2005, Matsuya, Yuji et. al.
An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification
score: 1.8323187, Bioorganic & Medicinal Chemistry Letters, 2004, Dubowchik, Gene M.; Michne, Jodi A.; Zuev, Dmitry
Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012
score: 1.8319602, Bioorganic & Medicinal Chemistry Letters, 2012, Galley, Guido et. al.
Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1 H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors
score: 1.8317504, Bioorganic & Medicinal Chemistry, 2010, Zhang, Li et. al.
Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists
score: 1.8313352, European Journal of Medicinal Chemistry, 2012, Su, Jung-Chen et. al.
Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists
score: 1.8313352, European Journal of Medicinal Chemistry, 2012, Su, Jung-Chen et. al.
Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents
score: 1.8312491, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Qian et. al.
Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents
score: 1.8312491, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Qian et. al.
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors
score: 1.8307147, European Journal of Medicinal Chemistry, 2012, Rajak, Harish et. al.
Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors
score: 1.8304631, Bioorganic & Medicinal Chemistry, 2001, Suzuki, Mikio et. al.
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
score: 1.830344, Bioorganic & Medicinal Chemistry Letters, 2012, Nakamura, Yuji et. al.
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
score: 1.830344, Bioorganic & Medicinal Chemistry Letters, 2012, Nakamura, Yuji et. al.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
score: 1.8301137, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
score: 1.8301137, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
score: 1.8301137, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Solid-phase synthesis of 1,3,4-oxadiazoline-5-thione derivatives from resin-bound acylhydrazines
score: 1.8299123, Bioorganic & Medicinal Chemistry Letters, 2006, Liu, Zhanxiang; Zhao, Jinlong; Huang, Xian
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
score: 1.8298083, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
Exploration of the structure–activity relationship of the diaryl anilide class of ligands for translocator protein—potential novel positron emitting tomography imaging agents
score: 1.8296689, Bioorganic & Medicinal Chemistry Letters, 2012, Wadsworth, Harry et. al.
C–N bond formation under Cu-catalysis: Synthesis and in vitro evaluation of N-aryl substituted thieno[2,3-d]pyrimidin-4(3H)-ones against chorismate mutase
score: 1.8293056, Bioorganic & Medicinal Chemistry, 2012, Adepu, Raju et. al.
Phenolic compounds as antiangiogenic CMG2 inhibitors from costa rican endophytic fungi1
score: 1.8290042, Bioorganic & Medicinal Chemistry Letters, 2012, Cao, Shugeng et. al.
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position
score: 1.8286875, Bioorganic & Medicinal Chemistry Letters, 2012, Hamada, Yoshio et. al.
A Convenient Synthesis and Hepatoprotective Activity of Imidazo[1,2- c]pyrimido[5,4- e]pyrimidine, Tetraazaacenaphthene and Tetraazaphenalene from Cyclic Ketene Aminals Through Tandem Addition-Cyclization Reactions ‡ ‡ CDRI communication number 5986.
score: 1.8285808, Bioorganic & Medicinal Chemistry, 2002, Ram, Vishnu J; Goel, Atul; Sarkhel, Sanjay; Maulik, Prakas R
Ligand and structure based pharmacophore modeling to facilitate novel histone deacetylase 8 inhibitor design
score: 1.8284128, European Journal of Medicinal Chemistry, 2010, Thangapandian, Sundarapandian et. al.
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca 2+ release from sarcoplasmic reticulum of skeletal muscle
score: 1.8283287, Bioorganic & Medicinal Chemistry Letters, 2005, Hosoya, Takamitsu et. al.
Three-dimensional quantitative structure–activity studies of octopaminergic agonists responsible for the inhibition of sex-pheromone production in Hercoverpa armigera
score: 1.8281121, Bioorganic & Medicinal Chemistry, 1999, Hirashima, Akinori et. al.
Docking and 3D-QSAR studies of BMS-806 analogs as HIV-1 gp120 entry inhibitors
score: 1.8280259, European Journal of Medicinal Chemistry, 2009, Teixeira, C.; Serradji, N.; Maurel, F.; Barbault, F.
Synthesis and Biological Evaluation of Antifungal Derivatives of Enfumafungin as Orally Bioavailable Inhibitors of β1,3-Glucan Synthase
score: 1.8280138, Bioorganic & Medicinal Chemistry Letters, 2012, Heasley, Brian H. et. al.
Design, Synthesis and vasodilative activity of tanshinone IIA derivatives
score: 1.8278078, Bioorganic & Medicinal Chemistry Letters, 2012, Bi, Yue-Feng et. al.
Cyclic urea derivatives as potent NK 1 selective antagonists
score: 1.8274407, Bioorganic & Medicinal Chemistry Letters, 2005, Shue, Ho-Jane et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.8274252, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.8274252, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.8274252, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Synthesis and evaluation of anti-thrombotic activity of benzocoumarin amide derivatives
score: 1.8273169, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Synthesis and evaluation of anti-thrombotic activity of benzocoumarin amide derivatives
score: 1.8273169, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Novel ketolide antibiotics with a fused five-membered lactone ring––synthesis, physicochemical and antimicrobial properties
score: 1.8271434, Bioorganic & Medicinal Chemistry, 2004, Hunziker, Daniel et. al.
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production
score: 1.8269621, Bioorganic & Medicinal Chemistry, 2012, Lee, Bit et. al.
Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases
score: 1.826878, Bioorganic & Medicinal Chemistry, 2006, Sondhi, Sham M. et. al.
Novel synthesis of 2′- O-methylguanosine
score: 1.8268419, Bioorganic & Medicinal Chemistry Letters, 2003, Chow, Suetying et. al.
3D QSAR for GSK-3β inhibition by indirubin analogues
score: 1.8267726, European Journal of Medicinal Chemistry, 2006, Zhang, Na et. al.
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
score: 1.8264927, Bioorganic & Medicinal Chemistry, 2012, Lang, Karen Luise et. al.
Synthesis of new bioactive venlafaxine analogs: Novel thiazolidin-4-ones as antimicrobials
score: 1.8263706, Bioorganic & Medicinal Chemistry, 2006, Kavitha, C.V. et. al.
Synthesis and antibacterial activity of 6-O-(heteroaryl-isoxazolyl)propynyl 2-fluoro ketolides
score: 1.8261539, Bioorganic & Medicinal Chemistry Letters, 2012, Sugimoto, Tomohiro et. al.
Discovery of XL413, a potent and selective CDC7 Inhibitor
score: 1.8261317, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Synthesis and biological activity of novel S-Adenosyl- l-homocysteine hydrolase inhibitors
score: 1.8260698, Bioorganic & Medicinal Chemistry, 2003, Steere, Jennifer A; Honek, John F
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
score: 1.8257793, European Journal of Medicinal Chemistry, 2013, Yaziji, Vicente et. al.
Synthesis and structure–activity relationships (SARs) of 1,5-diarylpyrazole cannabinoid type-1 (CB 1) receptor ligands for potential use in molecular imaging
score: 1.8257711, Bioorganic & Medicinal Chemistry, 2006, Donohue, Sean R.; Halldin, Christer; Pike, Victor W.
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone
score: 1.8256622, Bioorganic & Medicinal Chemistry Letters, 2012, Carter, Percy H. et. al.
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone
score: 1.8256622, Bioorganic & Medicinal Chemistry Letters, 2012, Carter, Percy H. et. al.
Combined receptor-based and ligand-based approach to delineate the mode of binding of guaianolide–endoperoxides to PfATP6
score: 1.8255762, Bioorganic & Medicinal Chemistry Letters, 2012, Helal, Mohamed A.; Avery, Mitchell A.
Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation
score: 1.8255153, Bioorganic & Medicinal Chemistry, 2006, Kaffy, Julia et. al.
2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.
score: 1.8254295, Antimicrobial agents and chemotherapy, 2012, Rodrígues-Poveda, Carlos A et. al.
Consensus hologram QSAR modeling for the prediction of human intestinal absorption
score: 1.8253333, Bioorganic & Medicinal Chemistry Letters, 2012, Moda, Tiago L.; Andricopulo, Adriano D.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.8252433, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Analogues of the mycobacterial arabinogalactan linkage disaccharide as cell wall biosynthesis inhibitors
score: 1.8250862, Bioorganic & Medicinal Chemistry, 2003, Wen, Xianghui et. al.
Potent acetylcholinesterase inhibitors: design, synthesis, and structure–Activity relationships of bis-interacting ligands in the galanthamine series
score: 1.8250204, Bioorganic & Medicinal Chemistry, 1998, Mary, Aude et. al.
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides
score: 1.8249607, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiaozhuo et. al.
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don
score: 1.8248623, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Yeon Ho et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole- 2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 1.8247887, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants
score: 1.8246226, Bioorganic & Medicinal Chemistry Letters, 2012, Dang, Zhao et. al.
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain
score: 1.8244859, Bioorganic & Medicinal Chemistry, 2003, Huang, Lily; Brinen, Linda S.; Ellman, Jonathan A.
Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis
score: 1.8244101, Bioorganic & Medicinal Chemistry, 2012, Jónsdóttir, Svava Ósk et. al.
Studies of cannabinoid-1 receptor antagonists for the treatment of obesity: Hologram QSAR model for biarylpyrazolyl oxadiazole ligands
score: 1.8243009, Bioorganic & Medicinal Chemistry Letters, 2009, Ye, Mao; Dawson, Marcia I.
Synthesis of [ 11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase
score: 1.824299, Bioorganic & Medicinal Chemistry Letters, 2006, Wang, Ji-Quan et. al.
Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device
score: 1.8240645, Bioorganic & Medicinal Chemistry, 2009, Nishiyama, Kazusa et. al.
New analogues of AHMA as potential antitumor agents: synthesis and biological activity
score: 1.8240501, Bioorganic & Medicinal Chemistry, 2003, Chang, Jang-Yang et. al.
Synthesis and biological evaluation of modified acridines: the effect of N- and O- substituent in the nitrogenated ring on antitumor activity
score: 1.8237153, European Journal of Medicinal Chemistry, 2006, Sánchez, Isabel et. al.
Development of In-Silico Filters to Predict Activation of the Pregnane X Receptor (PXR) by Structurally Diverse Drug-Like Molecules
score: 1.8234708, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
N-Alkoxypyrazoles as biomimetics for the alkoxyphenyl group in tamoxifen
score: 1.8231228, Bioorganic & Medicinal Chemistry, 2003, Wenckens, Martin et. al.
Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C 17(20) Lyase
score: 1.8230733, Bioorganic & Medicinal Chemistry, 2002, Burkhart, Joseph P et. al.
Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease
score: 1.822947, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Yun Suk et. al.
Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease
score: 1.822947, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Yun Suk et. al.
Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease
score: 1.822947, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Yun Suk et. al.
Synthesis and biological evaluation of a-Ring biaryl-carbamate analogues of rhazinilam
score: 1.8229103, Bioorganic & Medicinal Chemistry, 2002, Baudoin, Olivier et. al.
Structure–activity relationship study of homoallylamines and related derivatives acting as antifungal agents
score: 1.8228997, Bioorganic & Medicinal Chemistry, 2006, Suvire, Fernando D. et. al.
Highly potent PDE4 inhibitors with therapeutic potential
score: 1.8226582, Bioorganic & Medicinal Chemistry, 2004, Ochiai, Hiroshi et. al.
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
score: 1.8226514, Bioorganic & Medicinal Chemistry Letters, 2012, DeBerardinis, Albert M. et. al.
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
score: 1.8226514, Bioorganic & Medicinal Chemistry Letters, 2012, DeBerardinis, Albert M. et. al.
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
score: 1.8226514, Bioorganic & Medicinal Chemistry Letters, 2012, DeBerardinis, Albert M. et. al.
Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies
score: 1.8226202, Bioorganic & Medicinal Chemistry, 2005, Shim, Yi Sup et. al.
Towards NR2B receptor selective imaging agents for PET—synthesis and evaluation of N-[ 11C]-(2-methoxy)benzyl ( E)-styrene-, 2-naphthyl- and 4-trifluoromethoxyphenylamidine
score: 1.8225595, Bioorganic & Medicinal Chemistry, 2006, Årstad, Erik et. al.
Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7 H-pyrazolo[4,3- d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
score: 1.8222055, Bioorganic & Medicinal Chemistry, 2001, Kim, Dae-Kee et. al.
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.8221397, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294
score: 1.8218557, Bioorganic & Medicinal Chemistry Letters, 2010, Carneiro, Emmanuel O. et. al.
Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics
score: 1.8217166, Bioorganic & Medicinal Chemistry, 2005, Chruma, Jason J.; Liu, Lei; Zhou, Wenjun; Breslow, Ronald
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.8216052, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.8216052, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.8216052, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds
score: 1.8213113, Bioorganic & Medicinal Chemistry, 2004, Venkatachalam, T.K; Mao, C; Uckun, Fatih.M
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 1.8212766, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists
score: 1.8212179, Bioorganic & Medicinal Chemistry, 2012, Cilibrizzi, Agostino et. al.
Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists
score: 1.8212179, Bioorganic & Medicinal Chemistry, 2012, Cilibrizzi, Agostino et. al.
Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists
score: 1.8212179, Bioorganic & Medicinal Chemistry, 2012, Cilibrizzi, Agostino et. al.
Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents
score: 1.8211728, Bioorganic & Medicinal Chemistry Letters, 2013, Yeung, Kap-Sun et. al.
Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D 3: synthesis and preliminary biological evaluation
score: 1.8205066, Bioorganic & Medicinal Chemistry, 2005, Posner, Gary H. et. al.
Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.
score: 1.8203147, Antimicrobial agents and chemotherapy, 2011, Walker, Scott S et. al.
Guanacastane-type diterpenoids with cytotoxic activity from Coprinus plicatilis
score: 1.8201518, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yuanzhen et. al.
Synthesis and anti- Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs
score: 1.8199176, European Journal of Medicinal Chemistry, 1999, Patrick, Donald A. et. al.
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.8196189, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Design, synthesis and biological evaluation of nonpeptide integrin antagonists
score: 1.8194453, Bioorganic & Medicinal Chemistry, 1998, Nicolaou, K.C. et. al.
Angiogenesis inhibitor TX-1898: syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers
score: 1.8192618, Bioorganic & Medicinal Chemistry, 2004, Jin, Cheng-Zhe et. al.
Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation
score: 1.819037, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Design, synthesis, and structure–activity relationships of potent GPIIb/IIIa antagonists: discovery of FK419
score: 1.8187861, Bioorganic & Medicinal Chemistry, 2005, Yamanaka, Toshio et. al.
Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents
score: 1.8187378, Bioorganic & Medicinal Chemistry Letters, 2010, Di Gianvincenzo, Paolo et. al.
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8186063, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8186063, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8186063, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation
score: 1.8184532, Bioorganic & Medicinal Chemistry, 2005, Borrel, Christine et. al.
Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp.
score: 1.8182103, Bioorganic & Medicinal Chemistry, 2005, Cao, Shugeng et. al.
Conformations in solution and bound to bacterial ribosomes of ketolides, HMR 3647 (telithromycin) and RU 72366: A new class of highly potent antibacterials
score: 1.8180843, Bioorganic & Medicinal Chemistry, 2000, Evrard-Todeschi, Nathalie et. al.
The structural basis for kainoid selectivity at AMPA receptors revealed by low-mode docking calculations
score: 1.8173404, Bioorganic & Medicinal Chemistry, 2003, Carcache, Luis M; Rodriguez, Jonierr; Rein, Kathleen S
Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine
score: 1.8171927, Bioorganic & Medicinal Chemistry, 2004, Delfourne, Evelyne et. al.
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
score: 1.8169482, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Pinhong et. al.
Synthesis of heterocycles containing two cytosine or two guanine base-pairing sites. Novel tectons for self-assembly
score: 1.8167785, Bioorganic & Medicinal Chemistry, 1996, Petersen, Paul M. et. al.
Quantitative relationship between rat intestinal absorption and Abraham descriptors
score: 1.8163024, European Journal of Medicinal Chemistry, 2003, Zhao, Yuan H et. al.
Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents
score: 1.8160855, European Journal of Medicinal Chemistry, 2012, Zhu, Lingjian et. al.
Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents
score: 1.8160855, European Journal of Medicinal Chemistry, 2012, Zhu, Lingjian et. al.
Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors
score: 1.8159823, European Journal of Medicinal Chemistry, 2013, Abuhaie, Cristina-Maria et. al.
Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors
score: 1.8159823, European Journal of Medicinal Chemistry, 2013, Abuhaie, Cristina-Maria et. al.
Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs
score: 1.8157036, Bioorganic & Medicinal Chemistry, 2006, Hanson, Sarah R.; Whalen, Lisa J.; Wong, Chi-Huey
Novel nitric oxide-releasing isochroman-4-one derivatives: synthesis and evaluation of antihypertensive activity
score: 1.8157033, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
score: 1.8154246, Bioorganic & Medicinal Chemistry Letters, 2012, Hansen, Finn K. et. al.
3-Bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin: Synthesis and antiviral activity
score: 1.8152371, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Chong; Chen, Qi; Schneller, Stewart W.
Synthesis and testing of a triaza-cyclopenta[ b]phenanthrene scaffold as a DNA binding agent
score: 1.8151575, Bioorganic & Medicinal Chemistry, 2006, Hooda, Jaipal et. al.
Novel synthesis of nicotinamide derivatives of cytotoxic properties
score: 1.8151156, Bioorganic & Medicinal Chemistry, 2006, Girgis, Adel S.; Hosni, Hanaa M.; Barsoum, Flora F.
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists
score: 1.8149159, Bioorganic & Medicinal Chemistry, 2006, Naganawa, Atsushi et. al.
Synthesis and anticancer evaluation of certain indolo[2,3- b]quinoline derivatives
score: 1.8149114, Bioorganic & Medicinal Chemistry, 2004, Chen, Yeh-Long et. al.
Non-thiol Farnesyltransferase Inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic Acid Amides
score: 1.8148523, Bioorganic & Medicinal Chemistry, 2002, Sakowski, Jacek; Sattler, Isabel; Schlitzer, Martin
Discovery of novel α1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands
score: 1.814254, Bioorganic & Medicinal Chemistry, 2013, Jørgensen, Morten et. al.
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety
score: 1.8141942, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Qing-Rong et. al.
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety
score: 1.8141942, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Qing-Rong et. al.
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety
score: 1.8141942, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Qing-Rong et. al.
Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors
score: 1.8140486, Bioorganic & Medicinal Chemistry, 2005, Chen, Qiao-Hong; Rao, P.N. Praveen; Knaus, Edward E.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.8135264, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8130641, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8130641, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
score: 1.8128946, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
score: 1.8128946, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives
score: 1.8127819, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives
score: 1.8127819, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives
score: 1.8127819, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
score: 1.8127527, European Journal of Medicinal Chemistry, 2012, van Heerden, Lezanne et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.8122786, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.8122786, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.8122786, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8118305, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8118305, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Novel diaryl ureas with efficacy in a mouse model of malaria
score: 1.8117319, Bioorganic & Medicinal Chemistry Letters, 2013, Anderson, John W. et. al.
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors
score: 1.811448, European Journal of Medicinal Chemistry, 2012, Iranshahi, Mehrdad et. al.
Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation
score: 1.8112373, Bioorganic & Medicinal Chemistry Letters, 2012, Nemoto, Hisao et. al.
Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies
score: 1.811097, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xinyang et. al.
Design, synthesis, and development of novel caprolactam anticonvulsants
score: 1.8104065, Bioorganic & Medicinal Chemistry, 2003, Grimm, Jonathan B; Stables, James P; Brown, Milton L
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8103884, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
Synthesis and receptor assay of aromatic–ethynyl–aromatic derivatives with potent mGluR5 antagonist activity
score: 1.8103372, Bioorganic & Medicinal Chemistry, 2005, Alagille, David et. al.
An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction
score: 1.8100354, Bioorganic & Medicinal Chemistry Letters, 2012, Hossein nia, Roghayeh et. al.
Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist
score: 1.8098429, Bioorganic & Medicinal Chemistry, 2005, Andersen, Trine F. et. al.
BC-spiro-estradiols. Synthesis and estrogen receptor binding affinity of four new estradiol isomers
score: 1.8095777, Bioorganic & Medicinal Chemistry Letters, 2012, Asim, Muhammad et. al.
Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases
score: 1.8094482, European Journal of Medicinal Chemistry, 2012, Čapkauskaitė, Edita et. al.
Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases
score: 1.8094482, European Journal of Medicinal Chemistry, 2012, Čapkauskaitė, Edita et. al.
A quantitative assessment of hERG liability as a function of lipophilicity
score: 1.8094024, Bioorganic & Medicinal Chemistry Letters, 2007, Waring, Michael J.; Johnstone, Craig
Quantitative structure and aldose reductase inhibitory activity relationship of 1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazine-4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone derivatives
score: 1.8090002, Bioorganic & Medicinal Chemistry, 2005, Ko, Kwangseok; Won, Youngdo
Structure-Based drug design: synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo[ b]oxepines as non-steroidal estrogens
score: 1.8085437, Bioorganic & Medicinal Chemistry, 2003, Sarkhel, Sanjay et. al.
QSAR study on thiazole and thiadiazole analogues as antagonists for the adenosine A 1 and A 3 receptors
score: 1.8084862, Bioorganic & Medicinal Chemistry, 2005, Borghini, Alice et. al.
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus
score: 1.8083637, Bioorganic & Medicinal Chemistry Letters, 2013, Park, Kaapjoo et. al.
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
score: 1.8082819, Bioorganic & Medicinal Chemistry, 2012, Perez-Meseguer, Jonathan et. al.
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
score: 1.8082819, Bioorganic & Medicinal Chemistry, 2012, Perez-Meseguer, Jonathan et. al.
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
score: 1.8082819, Bioorganic & Medicinal Chemistry, 2012, Perez-Meseguer, Jonathan et. al.
Stimulation on DNA triplet repeat strand slippage synthesis by the designed spirocycles
score: 1.8081566, Bioorganic & Medicinal Chemistry Letters, 2006, Xi, Zhen; Ouyang, Di; Mu, Hong-Tao
Total synthesis and stereochemistry of cytoblastin
score: 1.8081147, Bioorganic & Medicinal Chemistry, 1998, Moreno, Ofir A.; Kishi, Yoshito
Protein structure based rational design of ecdysone agonists
score: 1.80804, Bioorganic & Medicinal Chemistry, 2009, Holmwood, Graham; Schindler, Michael
QSAR studies of N 1-(5-chloro-2-pyridyl)-2-{[4-(alkyl methyl)benzoyl]amino}-5-chlorobenzamide analogs
score: 1.8074433, Bioorganic & Medicinal Chemistry, 2006, Rameshwar, N. et. al.
Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT
score: 1.8074312, Bioorganic & Medicinal Chemistry, 2012, Clark, Rachel L. et. al.
Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
score: 1.8071101, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity
score: 1.8069572, Bioorganic & Medicinal Chemistry Letters, 2012, Peña, Stella et. al.
Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties
score: 1.8067618, Bioorganic & Medicinal Chemistry Letters, 2008, Kamino, Shinichiro et. al.
Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators
score: 1.8067215, Bioorganic & Medicinal Chemistry, 2012, Sabbah, Mohamad et. al.
Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [ 3H]Glyburide binding to rat brain synaptosomes
score: 1.8066906, Bioorganic & Medicinal Chemistry, 2003, Hill, Ronald A. et. al.
Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease.
score: 1.8065877, Antimicrobial agents and chemotherapy, 2006, Perni, Robert B et. al.
Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.
score: 1.8064643, Antimicrobial agents and chemotherapy, 2000, Gozalbes, R et. al.
Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity
score: 1.8063736, Bioorganic & Medicinal Chemistry, 2006, Zhao, Ming et. al.
Three-dimensional quantitative structure–activity relationship analyses of piperidine-based CCR5 receptor antagonists
score: 1.8060942, Bioorganic & Medicinal Chemistry, 2004, Song, Minghu; Breneman, Curt M.; Sukumar, N.
Synthesis and selective anticancer activity of steroidal glycoconjugates
score: 1.8059284, European Journal of Medicinal Chemistry, 2012, Fernández-Herrera, María A. et. al.
Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains
score: 1.8058795, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Shuxiang et. al.
2-Arylbenzofuran-Based Molecules As Multipotent Alzheimer's Disease Modifying Agents
score: 1.8057094, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3′- C-ethynyluridine (EUrd) and 3′- C-ethynylcytidine (ECyd)
score: 1.8053909, Bioorganic & Medicinal Chemistry, 2005, Hrdlicka, Patrick J. et. al.
The therapeutic journey of benzimidazoles: A review
score: 1.8053298, Bioorganic & Medicinal Chemistry, 2012, Bansal, Yogita; Silakari, Om
The therapeutic journey of benzimidazoles: A review
score: 1.8053298, Bioorganic & Medicinal Chemistry, 2012, Bansal, Yogita; Silakari, Om
Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica
score: 1.8051592, European Journal of Medicinal Chemistry, 2005, Sharma, Sangita et. al.
Potent inhibitors of the hepatitis C virus NS3 protease: Use of a novel P2 cyclopentane-derived template
score: 1.8050915, Bioorganic & Medicinal Chemistry, 2006, Johansson, Per-Ola et. al.
Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors
score: 1.8050297, Bioorganic & Medicinal Chemistry, 2003, Hu, Wenhui et. al.
Effect of substitution at N″-position of N′-hydroxy-N-amino guanidines on tumor cell growth
score: 1.8042659, Bioorganic & Medicinal Chemistry Letters, 2012, Basu, Arijit et. al.
An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivatives
score: 1.804252, Bioorganic & Medicinal Chemistry Letters, 2012, Chobe, Santosh S. et. al.
An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivatives
score: 1.804252, Bioorganic & Medicinal Chemistry Letters, 2012, Chobe, Santosh S. et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.8042449, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
Ligand design and synthesis of new imidazo[5,1- b]quinazoline derivatives as α 1-adrenoceptor agonists and antagonists
score: 1.8041838, Bioorganic & Medicinal Chemistry, 2006, Ismail, Mohamed A.H. et. al.
New multipotent tetracyclic tacrines with neuroprotective activity
score: 1.8039904, Bioorganic & Medicinal Chemistry, 2006, Marco-Contelles, José et. al.
Synthesis and antitumor activity of duocarmycin derivatives: modification at the C-7 position of segment-A of A-ring pyrrole compounds
score: 1.8038577, Bioorganic & Medicinal Chemistry, 2000, Amishiro, Nobuyoshi et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.8038127, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Synthesis and evaluation of small libraries of triazolylmethoxy chalcones, flavanones and 2-aminopyrimidines as inhibitors of mycobacterial FAS-II and PknG
score: 1.803684, Bioorganic & Medicinal Chemistry, 2012, Anand, Namrata et. al.
Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes
score: 1.8032083, Bioorganic & Medicinal Chemistry, 2003, Ghosh, Usha et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8031811, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8031811, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8031811, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
Design, synthesis and cytotoxic effect of hydroxy- and 3-alkylaminopropoxy-9,10-anthraquinone derivatives
score: 1.8030397, Bioorganic & Medicinal Chemistry, 2005, Teng, Chi-Huang; Won, Shen-Jeu; Lin, Chun-Nan
Synthesis and biological evaluation of novel 2, 4, 6-triazine derivatives as antimicrobial agents
score: 1.8029506, Bioorganic & Medicinal Chemistry Letters, 2012, Gavade, Sandip N. et. al.
Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).
score: 1.8027476, Antimicrobial agents and chemotherapy, 2012, McPhee, Fiona et. al.
Triazolbenzo[d]thiazoles: Efficient synthesis and biological evaluation as neuroprotective agents
score: 1.8027212, Bioorganic & Medicinal Chemistry Letters, 2012, Avila, Belem et. al.
QSAR analysis of 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridines with anticancer activity
score: 1.802453, European Journal of Medicinal Chemistry, 2007, Atanasova, Mariyana; Ilieva, Sonia; Galabov, Boris
Active site binding modes of the β-diketoacids: a multi-active site approach in HIV-1 integrase inhibitor design
score: 1.8014849, Bioorganic & Medicinal Chemistry, 2004, Dayam, Raveendra; Neamati, Nouri
Tuberculosis: The drug development pipeline at a glance
score: 1.8014841, European Journal of Medicinal Chemistry, 2012, Villemagne, Baptiste et. al.
Tuberculosis: The drug development pipeline at a glance
score: 1.8014841, European Journal of Medicinal Chemistry, 2012, Villemagne, Baptiste et. al.
Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti- Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design
score: 1.8011944, European Journal of Medicinal Chemistry, 2004, Aguirre, Gabriela et. al.
Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists
score: 1.8011725, Bioorganic & Medicinal Chemistry, 1996, Ojo, Babatunde et. al.
Synthesis of the tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium
score: 1.8010253, Bioorganic & Medicinal Chemistry Letters, 2006, Saksena, Rina; Adamo, Roberto; Kováč, Pavol
Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity
score: 1.8006475, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity
score: 1.8006475, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity
score: 1.8006475, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles
score: 1.8006329, European Journal of Medicinal Chemistry, 2003, Shivarama Holla, B et. al.
Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide incorporating 7-deazaguanine bases
score: 1.8005353, Bioorganic & Medicinal Chemistry, 2006, Jain, Moti L.; Bruice, Thomas C.
Potent DNA gyrase inhibitors; novel 5-vinylpyrazole analogues with Gram-positive antibacterial activity
score: 1.8002571, Bioorganic & Medicinal Chemistry Letters, 2004, Tanitame, Akihiko et. al.
Synthesis and biological activity of isopentenyl diphosphate analogues
score: 1.7998896, Bioorganic & Medicinal Chemistry, 2004, Scholte, Andrew A et. al.
Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties
score: 1.7997231, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Yan; Ma, Long-Xu; Niu, Tian-Wei; Cui, Xun; Piao, Hu-Ri
Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties
score: 1.7997231, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Yan; Ma, Long-Xu; Niu, Tian-Wei; Cui, Xun; Piao, Hu-Ri
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones
score: 1.7995868, Bioorganic & Medicinal Chemistry, 2003, Kang, Ji-Hye et. al.
2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents
score: 1.7992311, European Journal of Medicinal Chemistry, 2013, Azizmohammadi, Mohammad et. al.
Synthesis of highly deuterium-labeled ( R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma
score: 1.799166, Bioorganic & Medicinal Chemistry, 2009, Yamazaki, Yukiyoshi; Ogawa, Shin-ichiro; Shibuya, Kimiyuki
Facile synthesis and application of uniformly 13C, 15N-labeled phosphotyrosine for ligand binding studies
score: 1.7989625, Bioorganic & Medicinal Chemistry Letters, 2006, Tuin, Adriaan W. et. al.
Newer N-substituted anthranilic acid derivatives as potent anti-inflammatory agents
score: 1.7987048, European Journal of Medicinal Chemistry, 2002, Sharma, Shalabh; Srivastava, Virendra Kishor; Kumar, Ashok
Synthesis and biological evaluation of 5-arylamino-1 H-benzo[ d]imidazole-4,7-diones as inhibitor of endothelial cell proliferation
score: 1.7985542, Bioorganic & Medicinal Chemistry, 2006, Chung, Kwang-Hoe et. al.
Prediction of the aqueous solvation free energy of organic compounds by using autocorrelation of molecular electrostatic potential surface properties combined with response surface analysis
score: 1.7985357, Bioorganic & Medicinal Chemistry, 2008, Michielan, Lisa et. al.
Novel (4-Piperidin-1-yl)-phenyl Sulfonamides as Potent and Selective Human β 3 Agonists
score: 1.7978852, Bioorganic & Medicinal Chemistry, 2001, Hu, Baihua et. al.
Structure–activity study of l-amino acid-based N-type calcium channel blockers
score: 1.7977265, Bioorganic & Medicinal Chemistry, 2003, Seko, Takuya et. al.
An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivatives
score: 1.7976747, Bioorganic & Medicinal Chemistry Letters, 2012, Chobe, Santosh S. et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.797638, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition
score: 1.7973164, Bioorganic & Medicinal Chemistry Letters, 2012, Dossetter, Alexander G. et. al.
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping
score: 1.7969078, European Journal of Medicinal Chemistry, 2013, Chen, Qianqian et. al.
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping
score: 1.7969078, European Journal of Medicinal Chemistry, 2013, Chen, Qianqian et. al.
Synthesis of thiophenecarboxamides, thieno[3,4- c]pyridin-4(5 H)-ones and thieno[3,4- d]pyrimidin-4(3 H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)
score: 1.7965583, Bioorganic & Medicinal Chemistry, 1999, Shinkwin, Anne E. et. al.
Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure–activity relationship study
score: 1.7961117, Bioorganic & Medicinal Chemistry, 2004, Yin, Sheng et. al.
Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1 H-2-imidazolyl]methanols, [5- tert-Butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1 H-2-imidazolyl]methanol, and [2-Hydroxyaryl]-[1-methyl-5-nitro-1 H-2-imidazolyl] ketones
score: 1.7960975, Bioorganic & Medicinal Chemistry, 1997, Arredondo, Y. et. al.
Novel synthesis of 2-Substituted 19-norvitamin D A-ring phosphine oxide from d-glucose as a building block
score: 1.7960938, Bioorganic & Medicinal Chemistry Letters, 2003, Shimizu, Masato et. al.
Mining the NCI antiviral compounds for HIV-1 integrase inhibitors
score: 1.7959061, Bioorganic & Medicinal Chemistry, 2006, Deng, Jinxia et. al.
Synthesis and structure–activity relationship of disubstituted benzamides as a novel class of antimalarial agents
score: 1.795805, Bioorganic & Medicinal Chemistry Letters, 2012, Mitachi, Katsuhiko et. al.
Synthesis and structure–activity relationship of disubstituted benzamides as a novel class of antimalarial agents
score: 1.795805, Bioorganic & Medicinal Chemistry Letters, 2012, Mitachi, Katsuhiko et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.7957506, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
The application of a 3D-QSAR ( autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: Application to a lead optimization of a human A 3 adenosine receptor antagonist
score: 1.7957354, Bioorganic & Medicinal Chemistry, 2006, Moro, Stefano et. al.
Dicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations.
score: 1.7955294, Antimicrobial agents and chemotherapy, 2001, Nelson, R G; Rosowsky, A
Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509
score: 1.7952676, Bioorganic & Medicinal Chemistry, 1997, Hagishita, Sanji et. al.
Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509
score: 1.7952676, Bioorganic & Medicinal Chemistry, 1997, Hagishita, Sanji et. al.
Synthesis and muscarinic activities of O-[(Benzyl- or benzoyl-pyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone
score: 1.7948675, Bioorganic & Medicinal Chemistry, 2003, Rodrı́guez-Franco, Marı́a Isabel et. al.
Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
score: 1.7947652, Bioorganic & Medicinal Chemistry Letters, 2012, Uno, Masaharu et. al.
In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B
score: 1.7947119, Bioorganic & Medicinal Chemistry, 2012, Brvar, Matjaž et. al.
Squalenoyl nucleoside monophosphate nanoassemblies: New prodrug strategy for the delivery of nucleotide analogues
score: 1.7947056, Bioorganic & Medicinal Chemistry Letters, 2010, Caron, Joachim et. al.
Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors
score: 1.7946806, Bioorganic & Medicinal Chemistry Letters, 2004, Xu, Yong et. al.
Pyrrolidinobenzoic Acid Inhibitors of Influenza Virus Neuraminidase: the Hydrophobic Side Chain Influences Type A Subtype Selectivity
score: 1.794599, Bioorganic & Medicinal Chemistry, 2012, Li, Yanwu et. al.
Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties
score: 1.7945454, Bioorganic & Medicinal Chemistry, 2004, Johnsamuel, Jayaseharan et. al.
Characterization of novel antimicrobial peptoids.
score: 1.794479, Antimicrobial agents and chemotherapy, 1999, Goodson, B et. al.
Ligand discovery from a dopamine D3 receptor homology model and crystal structure.
score: 1.7942801, Nature chemical biology, 2011, Carlsson, Jens et. al.
The development of first Staphylococcus aureus SplB protease inhibitors: Phosphonic analogues of glutamine
score: 1.7935358, Bioorganic & Medicinal Chemistry Letters, 2012, Ewa, Burchacka et. al.
Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-β-carbolines
score: 1.7934126, Bioorganic & Medicinal Chemistry, 2005, Laronze, M. et. al.
Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents
score: 1.7933988, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Suhyun; Cho, Sang-Nae; Oh, Taegwon; Kim, Pilho
Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents
score: 1.7933988, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, SuHyun; Cho, Sang-Nae; Oh, Taegwon; Kim, Pilho
Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents
score: 1.7933988, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Suhyun; Cho, Sang-Nae; Oh, Taegwon; Kim, Pilho
Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor
score: 1.7929336, Bioorganic & Medicinal Chemistry Letters, 2005, Pontillo, Joseph et. al.
Biotransformation of gentiopicroside by asexual mycelia of Cordyceps sinensis
score: 1.7927028, Bioorganic & Medicinal Chemistry Letters, 2007, Wang, Dong et. al.
Exploration of the importance of the P 2-P 3 -NHCO-Moiety in a potent di- or tripeptide inhibitor of calpain i: insights into the development of nonpeptidic inhibitors of calpain I 1 1 Dedicated to Mrs Luxmi Chatterjee with respect and admiration.
score: 1.7920918, Bioorganic & Medicinal Chemistry, 1998, Chatterjee, Sankar et. al.
5′-Alkyl-benzothiadiazides: A New Subgroup of AMPA Receptor Modulators with Improved Affinity
score: 1.7916576, Bioorganic & Medicinal Chemistry, 2002, Phillips, Dean et. al.
Conformational search of antisense nucleotides
score: 1.7916552, Bioorganic & Medicinal Chemistry Letters, 2001, Alcaro, Stefano et. al.
Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity
score: 1.7912709, Bioorganic & Medicinal Chemistry Letters, 2012, Magedov, Igor V. et. al.
Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents
score: 1.7910549, Bioorganic & Medicinal Chemistry Letters, 2003, Poreddy, Amruta R. et. al.
Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents
score: 1.790911, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Yin et. al.
Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents
score: 1.790911, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Yin et. al.
Structure–activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent
score: 1.7907494, Bioorganic & Medicinal Chemistry, 2012, Mun, Jiyoung et. al.
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents
score: 1.7906387, Bioorganic & Medicinal Chemistry, 2006, Yoshida, Ken-ichi et. al.
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism
score: 1.7905114, Bioorganic & Medicinal Chemistry Letters, 2012, Pryde, David C. et. al.
Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: Optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase
score: 1.7904808, Bioorganic & Medicinal Chemistry, 2004, Yano, Shingo et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.7903003, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Analogs of N’-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 1.7901764, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Lewis acid-promoted transformation of 2-alkoxypyridines into 2-aminopyridines and their antibacterial activity. Part 2: Remarkably facile C–N bond formation
score: 1.7899813, Bioorganic & Medicinal Chemistry, 2005, Abdel-Aziz, Alaa A.-M. et. al.
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
score: 1.7899014, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
score: 1.7899014, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
score: 1.7899014, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7897697, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
Synthesis and in vitro stability of nucleoside 5’-phosphonate derivatives
score: 1.7895581, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Part 5
score: 1.7893234, Bioorganic & Medicinal Chemistry, 2006, Hazeldine, Stuart T. et. al.
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.7892529, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives
score: 1.7892437, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Cruz, Fernanda et. al.
Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide
score: 1.7892373, Bioorganic & Medicinal Chemistry Letters, 2012, Hasuda, Tomoyo et. al.
Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors.
score: 1.7890078, Antimicrobial agents and chemotherapy, 2007, Boyne, Melissa E et. al.
QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors
score: 1.7888485, Bioorganic & Medicinal Chemistry Letters, 2006, Narsinghani, Tamanna; Chaturvedi, S.C.
First Example of an Antibody-Catalyzed Aza Diels–Alder Reaction
score: 1.7888354, Bioorganic & Medicinal Chemistry Letters, 2002, Shi, Zhen-Dan et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7886425, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7886425, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7886425, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
QSTR with extended topochemical atom indices. Part 5: Modeling of the acute toxicity of phenylsulfonyl carboxylates to Vibrio fischeri using genetic function approximation
score: 1.7885328, Bioorganic & Medicinal Chemistry, 2005, Roy, Kunal; Ghosh, Gopinath
Synthesis and biological evaluation of carboacyclic nucleosides with ( Z) and ( E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain
score: 1.7884474, Bioorganic & Medicinal Chemistry, 2006, Tang, Ye; Muthyala, Ramaiah; Vince, Robert
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.78809, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.78809, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.78809, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
studies on anti- helicobacter pylori agents. part 2: new cephem derivatives
score: 1.7872456, Bioorganic & Medicinal Chemistry, 2000, Yoshida, Yoshiki et. al.
New diterpene furanoids from the Antarctic lichen Huea sp
score: 1.7871623, Bioorganic & Medicinal Chemistry Letters, 2012, Cui, Yinglan et. al.
New diterpene furanoids from the Antarctic lichen Huea sp
score: 1.7871623, Bioorganic & Medicinal Chemistry Letters, 2012, Cui, Yinglan et. al.
New diterpene furanoids from the Antarctic lichen Huea sp
score: 1.7871623, Bioorganic & Medicinal Chemistry Letters, 2012, Cui, Yinglan et. al.
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
score: 1.7870158, Bioorganic & Medicinal Chemistry Letters, 2012, Tamboli, Yasinalli et. al.
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
score: 1.7870158, Bioorganic & Medicinal Chemistry Letters, 2012, Tamboli, Yasinalli et. al.
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
score: 1.7870158, Bioorganic & Medicinal Chemistry Letters, 2012, Tamboli, Yasinalli et. al.
Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α1-adrenoceptor antagonistic properties
score: 1.7865047, Bioorganic & Medicinal Chemistry, 2012, Handzlik, Jadwiga et. al.
Design of a small-molecule entry inhibitor with activity against primary measles virus strains.
score: 1.7864445, Antimicrobial agents and chemotherapy, 2005, Plemper, Richard K et. al.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption
score: 1.7864097, Bioorganic & Medicinal Chemistry, 2012, Okaniwa, Masanori et. al.
A divergent chemoenzymatic route to an intermediate for nucleoside analogues
score: 1.7862475, Bioorganic & Medicinal Chemistry Letters, 2005, Basak, Amit; Bisai, Shrabani
In vitro antifungal evaluation and structure–activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall
score: 1.7861425, Bioorganic & Medicinal Chemistry, 2001, López, Silvia N et. al.
Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3- d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3- d]pyrimidine as antifolates
score: 1.7860272, Bioorganic & Medicinal Chemistry, 2006, Gangjee, Aleem; Yang, Jie; McGuire, John J.; Kisliuk, Roy L.
Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien
score: 1.7860053, Bioorganic & Medicinal Chemistry Letters, 2012, Altendorfer, Mario; Irschik, Herbert; Menche, Dirk
Synthesis and antihyperglycemic activity profiles of novel thiazolidinedione derivatives
score: 1.7857338, Bioorganic & Medicinal Chemistry, 2004, Bhat, Bashir A. et. al.
Effects of new ubiquinone-imidazo[2,1- b]thiazoles on mitochondrial complex I (NADH-ubiquinone reductase) and on mitochondrial permeability transition pore
score: 1.7856108, Bioorganic & Medicinal Chemistry, 2004, Andreani, Aldo et. al.
Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
score: 1.7855194, Bioorganic & Medicinal Chemistry, 2012, Herth, Matthias M. et. al.
Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
score: 1.7855194, Bioorganic & Medicinal Chemistry, 2012, Herth, Matthias M. et. al.
Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
score: 1.7855194, Bioorganic & Medicinal Chemistry, 2012, Herth, Matthias M. et. al.
Synthesis and antimicrobial activity of some novel derivatives of benzofuran: part 1. Synthesis and antimicrobial activity of (benzofuran-2-yl)(3-phenyl-3-methylcyclobutyl) ketoxime derivatives
score: 1.785504, European Journal of Medicinal Chemistry, 2005, Koca, Murat et. al.
Facile synthesis of anthracene-appended amino acids as highly selective and sensitive fluorescent Fe 3+ ion sensors
score: 1.7851632, Bioorganic & Medicinal Chemistry Letters, 2009, Lohani, Chuda Raj; Kim, Joung-Min; Lee, Keun-Hyeung
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.7850458, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.7847365, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
SAR directed design and synthesis of novel β(1-4)-Glucosyltransferase inhibitors and Their In vitro inhibition studies
score: 1.7845573, Bioorganic & Medicinal Chemistry, 2002, Bhattacharya, Asish K et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7843806, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7843806, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7843806, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Novel small renin inhibitors containing 4,5- or 3,5-dihydroxy-2-substituted-6-phenylhexanamide replacements at the P 2P 3 sites
score: 1.7842527, Bioorganic & Medicinal Chemistry, 1998, Jung, Grace L. et. al.
A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolothiazoles as antimycobacterial agents
score: 1.7841717, Bioorganic & Medicinal Chemistry Letters, 2012, Almansour, Abdulrahman I. et. al.
A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolidines as antimycobacterial agents
score: 1.7841717, Bioorganic & Medicinal Chemistry Letters, 2012, Almansour, Abdulrahman I. et. al.
A physicogenetic method to assign ligand-binding relationships between 7TM receptors
score: 1.7836233, Bioorganic & Medicinal Chemistry Letters, 2005, Frimurer, Thomas M. et. al.
The effect PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
The effect of PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
The effect PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
The effect of PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
Structure–activity relationships of antileishmanial and antimalarial chalcones
score: 1.782865, Bioorganic & Medicinal Chemistry, 2003, Liu, Mei et. al.
Aza-bicyclic amino acid carboxamides as α 4β 1/α 4β 7 integrin receptor antagonists
score: 1.7828051, Bioorganic & Medicinal Chemistry, 2005, Dyatkin, Alexey B. et. al.
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
score: 1.7827504, Antimicrobial agents and chemotherapy, 2012, Hall, Belinda S; Meredith, Emma Louise; Wilkinson, Shane R
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position
score: 1.7826681, Bioorganic & Medicinal Chemistry Letters, 2012, Hamada, Yoshio et. al.
Longifolicin, longicoricin, and gigantetroneninone, three novel bioactive mono-tetrahydrofuran annonaceous acetogenins from Asimina longifolia (annonaceae)
score: 1.7823096, Bioorganic & Medicinal Chemistry, 1996, Ye, Qing et. al.
Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase
score: 1.7819102, Bioorganic & Medicinal Chemistry, 2003, Njoroge, F.George et. al.
Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[ b]furan-3 a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition
score: 1.781838, Bioorganic & Medicinal Chemistry, 2004, Watts, John et. al.
Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3 H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigations
score: 1.7816647, Bioorganic & Medicinal Chemistry, 2005, Mamolo, Maria Grazia et. al.
Synthesis and DNA-binding ability of pyrrolo[2,1- c][1,4]benzodiazepine-azepane conjugates
score: 1.7815794, Bioorganic & Medicinal Chemistry Letters, 2006, Kamal, Ahmed et. al.
Exploring human adenosine A 3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety
score: 1.7814176, Bioorganic & Medicinal Chemistry, 2005, Van Rompaey, Philippe et. al.
Prenylated chalcones isolated from Crotalaria genus inhibits in vitro growth of the human malaria parasite Plasmodium falciparum
score: 1.7808073, Bioorganic & Medicinal Chemistry Letters, 2005, Narender, T. et. al.
Benzimidazole derivatives. Part 5: Design and synthesis of new benzimidazole–arylpiperazine derivatives acting as mixed 5-HT 1A/5-HT 3 ligands
score: 1.7807389, Bioorganic & Medicinal Chemistry, 2004, López-Rodríguez, María L. et. al.
Structure–activity relationship at α-adrenergic receptors within a series of imidazoline analogues of cirazoline
score: 1.7807183, Bioorganic & Medicinal Chemistry, 2000, Pigini, Maria et. al.
5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5- a]pyrazin-4(5 H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis
score: 1.7806604, Bioorganic & Medicinal Chemistry, 2008, Pan, Xiao-Hong et. al.
Development of 3,4-dihydro-2 H-benzo[1,4]oxazine derivatives as dual thromboxane A 2 receptor antagonists and prostacyclin receptor agonists
score: 1.7805906, Bioorganic & Medicinal Chemistry, 2006, Ohno, Michihiro et. al.
Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
score: 1.780408, Antimicrobial agents and chemotherapy, 2011, Barker, Robert H et. al.
Synthesis and Structure-Activity Relationship of Potent, Selective and Orally Active Anthranilamide-Based Factor Xa Inhibitors: Application of Weakly Basic Sulfoximine Group as Novel S4 Binding Element
score: 1.7802954, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Probing the proposed phenyl-A region of the sigma-1 receptor
score: 1.7802844, Bioorganic & Medicinal Chemistry, 2002, Ablordeppey, Seth Y et. al.
Synthesis of novel Gn-RH analogues using Ugi-4MCR
score: 1.7800545, Bioorganic & Medicinal Chemistry Letters, 2009, Arabanian, Armin et. al.
2D QSAR of PPARγ agonist binding and transactivation
score: 1.7800215, Bioorganic & Medicinal Chemistry, 2006, Rücker, Christoph; Scarsi, Marco; Meringer, Markus
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase
score: 1.779815, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase
score: 1.779815, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase
score: 1.779815, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.779809, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents
score: 1.7796337, Bioorganic & Medicinal Chemistry, 2013, Apostolidis, I. et. al.
Structure–activity studies of FIV and HIV protease inhibitors containing allophenylnorstatine
score: 1.77948, Bioorganic & Medicinal Chemistry, 2001, Le, Van-Duc et. al.
Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues
score: 1.7792329, Bioorganic & Medicinal Chemistry, 1997, Madalengoitia, Jose S. et. al.
Structure–activity studies of 3′-4′-dichloro-meperidine analogues at dopamine and serotonin transporters
score: 1.7792122, Bioorganic & Medicinal Chemistry, 2005, Rhoden, Jill B. et. al.
Synthesis and SOD activity of manganese complexes of substituted pyridino pentaaza macrocycles that contain axial auxiliary
score: 1.7791574, Bioorganic & Medicinal Chemistry Letters, 2010, Lee, Hakyoung; Park, Wonchoul; Lim, Dongyeol
Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors
score: 1.7790905, Bioorganic & Medicinal Chemistry, 2006, Rode, Haridas et. al.
Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity
score: 1.7789799, Bioorganic & Medicinal Chemistry, 2006, Goodell, John R. et. al.
Design, Synthesis, and Biological Evaluation of a Series of β-Lactam-Based Prodrugs
score: 1.7787886, Bioorganic & Medicinal Chemistry, 2002, Hakimelahi, Gholam Hossein et. al.
Microwave-assisted synthesis of unnatural amino acids
score: 1.7781867, Bioorganic & Medicinal Chemistry Letters, 2008, Young, Douglas D. et. al.
Template-competitive inhibitors of HIV-1 reverse transcriptase: design, synthesis and inhibitory activity
score: 1.7781373, Bioorganic & Medicinal Chemistry, 2002, Li, Ke et. al.
2,9-Disubstituted- N 6-(arylcarbamoyl)-8-azaadenines as new selective A 3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies
score: 1.7774745, Bioorganic & Medicinal Chemistry, 2005, Biagi, Giuliana et. al.
Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists
score: 1.7774561, Bioorganic & Medicinal Chemistry Letters, 2013, Gim, Hyo Jin; Li, Hua; Lee, Eun; Ryu, Jae-Ha; Jeon, Raok
Synthesis of acyclic 6,7-dihaloquinolone nucleoside analogues as potential antibacterial and antiviral agents
score: 1.7773841, Bioorganic & Medicinal Chemistry, 2000, Al-Masoudi, Najim A et. al.
Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.
score: 1.7772682, Antimicrobial agents and chemotherapy, 2010, Ribble, Wendy et. al.
The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin
score: 1.7765909, Bioorganic & Medicinal Chemistry Letters, 2012, Gendaszewska-Darmach, Edyta et. al.
The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin
score: 1.7765909, Bioorganic & Medicinal Chemistry Letters, 2012, Gendaszewska-Darmach, Edyta et. al.
Synthesis of an artificial glycoconjugate polymer carrying P k-antigenic trisaccharide and its potent neutralization activity against Shiga-like toxin
score: 1.7764427, Bioorganic & Medicinal Chemistry, 1999, Dohi, Hirofumi et. al.
Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity
score: 1.7763702, Bioorganic & Medicinal Chemistry, 2006, Hořejší, Kateřina et. al.
Structure-based discovery of human l-xylulose reductase inhibitors from database screening and molecular docking
score: 1.776188, Bioorganic & Medicinal Chemistry, 2005, Carbone, Vincenzo et. al.
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
score: 1.7760925, Bioorganic & Medicinal Chemistry Letters, 2012, Raheem, Izzat T. et. al.
A polymer-Supported [1,3,2]Oxazaphospholidine for the conversion of isothiocyanates to isocyanides and Their subsequent use in an ugi reaction
score: 1.7754818, Bioorganic & Medicinal Chemistry Letters, 2002, Ley, Steven V.; Taylor, Stephen J.
Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors
score: 1.7752237, Bioorganic & Medicinal Chemistry, 2012, Zhang, Shuting; Cheng, Kui; Wang, Xiaohui; Yin, Hang
Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs
score: 1.7751537, European Journal of Medicinal Chemistry, 2003, Charlier, Caroline; Michaux, Catherine
Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors
score: 1.7751484, Bioorganic & Medicinal Chemistry, 2004, Ishihara, Tsukasa et. al.
Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases
score: 1.775147, Bioorganic & Medicinal Chemistry, 2012, Wisastra, Rosalina et. al.
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold
score: 1.7750847, Bioorganic & Medicinal Chemistry, 2004, Knight, Zachary A. et. al.
QSAR studies of paeonol analogues for inhibition of platelet aggregation
score: 1.7747858, Bioorganic & Medicinal Chemistry, 2005, Doble, Mukesh et. al.
Synthesis of 4-methylcoumarin derivatives containing 4,5-dihydropyrazole moiety to scavenge radicals and to protect DNA
score: 1.7746187, European Journal of Medicinal Chemistry, 2012, Xiao, Chuan et. al.
C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor
score: 1.7740315, Bioorganic & Medicinal Chemistry Letters, 2012, Dixon, Darryl D. et. al.
Synthesis and biological evaluation of 5 R- and 5 S-methyl substituted d- and l-configuration 1,3-dioxolane nucleoside analogs
score: 1.7739967, Bioorganic & Medicinal Chemistry, 2004, Bera, Sanjib et. al.
Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents
score: 1.7739573, European Journal of Medicinal Chemistry, 2012, Caputto, María E. et. al.
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation
score: 1.773874, Bioorganic & Medicinal Chemistry Letters, 2012, Hicks, Justin W. et. al.
Structure-based engineering of benzalacetone synthase
score: 1.7737385, Bioorganic & Medicinal Chemistry Letters, 2010, Shimokawa, Yoshihiko; Morita, Hiroyuki; Abe, Ikuro
Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents
score: 1.7734637, Bioorganic & Medicinal Chemistry, 2013, Tarleton, Mark et. al.
Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor
score: 1.7734075, Bioorganic & Medicinal Chemistry Letters, 2012, Chaturvedula, Prasad V. et. al.
Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor
score: 1.7734075, Bioorganic & Medicinal Chemistry Letters, 2012, Chaturvedula, Prasad V. et. al.
Efficient synthesis of Idraparinux, the anticoagulant pentasaccharide
score: 1.7733523, Bioorganic & Medicinal Chemistry Letters, 2009, Chen, Chen; Yu, Biao
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
score: 1.7731906, Bioorganic & Medicinal Chemistry, 2012, Park, Ji-Young et. al.
Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
score: 1.7731207, Bioorganic & Medicinal Chemistry, 2012, Moorthy, N.S.H.N. et. al.
Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
score: 1.7731207, Bioorganic & Medicinal Chemistry, 2012, Moorthy, N.S.H.N. et. al.
Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
score: 1.7731207, Bioorganic & Medicinal Chemistry, 2012, Moorthy, N.S.H.N. et. al.
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands
score: 1.7728345, Bioorganic & Medicinal Chemistry, 2006, Zhao, Xue Zhi et. al.
Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors
score: 1.7724726, Bioorganic & Medicinal Chemistry, 2012, Zhang, Dengyou et. al.
Synthesis and in Vitro Antiproliferative Activity of New 11-Aminoalkylamino-Substituted 5H- and 6H-indolo[2,3-b]quinolines; Structure-Activity Relationships of Neocryptolepines and 6-Methyl Congeners
score: 1.7724195, Bioorganic & Medicinal Chemistry, 2012, Wang, Li et. al.
Estimation of the binding affinities of FKBP12 inhibitors using a linear response method
score: 1.7723804, Bioorganic & Medicinal Chemistry, 1999, Lamb, Michelle L. et. al.
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors
score: 1.7723082, Bioorganic & Medicinal Chemistry Letters, 2012, Jalily, Pouria H. et. al.
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors
score: 1.7723082, Bioorganic & Medicinal Chemistry Letters, 2012, Jalily, Pouria H. et. al.
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: Synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1 H-pyrazol-5-yl)-2-thiophenecarboxamides
score: 1.7722689, Bioorganic & Medicinal Chemistry, 2006, Yonetoku, Yasuhiro et. al.
Combined NMR-crystallographic and modelling investigation of the inclusion of molsidomine into α-, β- and γ-cyclodextrins
score: 1.7722604, Bioorganic & Medicinal Chemistry, 2005, Uccello-Barretta, Gloria et. al.
Ethenesulfonamide and ethanesulfonamide derivatives, a novel class of orally active endothelin-A receptor antagonists
score: 1.7721546, Bioorganic & Medicinal Chemistry, 2001, Harada, Hironori et. al.
Structure–activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors
score: 1.7721094, Bioorganic & Medicinal Chemistry, 2005, Maccari, Rosanna et. al.
Synthesis and antiprotozoal evaluation of benzothiazolopyrroloquinoxalinones, analogues of kuanoniamine A
score: 1.7719798, Bioorganic & Medicinal Chemistry, 2003, Tapia, Ricardo A. et. al.
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA
score: 1.7715734, Bioorganic & Medicinal Chemistry Letters, 2005, Xu, Yufang; Qu, Baoyuan; Qian, Xuhong; Li, Yonggang
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
score: 1.7709579, Antimicrobial agents and chemotherapy, 2004, Bruheim, Per et. al.
Structure–activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity
score: 1.7707282, Bioorganic & Medicinal Chemistry, 2004, Sekine, Mitsuo et. al.
Blocking HIV-1 entry by a gp120 surface binding inhibitor
score: 1.7703765, Bioorganic & Medicinal Chemistry Letters, 2012, Tsou, Lun K. et. al.
Blocking HIV-1 entry by a gp120 surface binding inhibitor
score: 1.7703765, Bioorganic & Medicinal Chemistry Letters, 2012, Tsou, Lun K. et. al.
Discovery and characterization of inhibitors of Pseudomonas aeruginosa type III secretion.
score: 1.7703523, Antimicrobial agents and chemotherapy, 2010, Aiello, Daniel et. al.
N-Alkylation of phenethylamine and tryptamine
score: 1.7702432, Bioorganic & Medicinal Chemistry Letters, 2005, Cami-Kobeci, Gerta et. al.
Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.
score: 1.7700358, Antimicrobial agents and chemotherapy, 2004, Iyer, Radhakrishnan P et. al.
Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.
score: 1.7690865, Bioorganic & Medicinal Chemistry Letters, 2012, Sivasothy, Yasodha et. al.
Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.
score: 1.7690865, Bioorganic & Medicinal Chemistry Letters, 2012, Sivasothy, Yasodha et. al.
Synthesis and evaluation of cis-hexahydropyrrolo[3,2- b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases
score: 1.7689985, Bioorganic & Medicinal Chemistry, 2005, Quibell, Martin et. al.
Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis
score: 1.7685756, Bioorganic & Medicinal Chemistry Letters, 2012, Jeankumar, Variam Ullas et. al.
Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis
score: 1.7685756, Bioorganic & Medicinal Chemistry Letters, 2012, Jeankumar, Variam Ullas et. al.
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase
score: 1.7682361, Bioorganic & Medicinal Chemistry Letters, 2012, Zhu, Rui et. al.
Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine
score: 1.7681924, Bioorganic & Medicinal Chemistry, 2006, Narendra Sharath Chandra, J.N. et. al.
A new class of pyrimidine nucleosides: inhibitors of hepatitis B and C viruses
score: 1.7679816, Bioorganic & Medicinal Chemistry Letters, 2012, Shakya, Neeraj et. al.
Application of descriptors based on Lipinski’s rules in the QSPR study of aqueous solubilities
score: 1.7679081, Bioorganic & Medicinal Chemistry, 2007, Duchowicz, Pablo R. et. al.
Investigation of structure–activity relationships in a series of glibenclamide analogues
score: 1.7676243, European Journal of Medicinal Chemistry, 2004, Yuriev, Elizabeth; Kong, David C.M.; Iskander, Magdy N.
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists
score: 1.7675676, Bioorganic & Medicinal Chemistry Letters, 2012, Dorange, Ismet et. al.
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists
score: 1.7675676, Bioorganic & Medicinal Chemistry Letters, 2012, Dorange, Ismet et. al.
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists
score: 1.7675676, Bioorganic & Medicinal Chemistry Letters, 2012, Dorange, Ismet et. al.
Solid-phase extraction on C18 silica as a purification strategy in the solution synthesis of a 1-thio-β- d-galactopyranoside library
score: 1.7675402, Bioorganic & Medicinal Chemistry, 1998, Nilsson, Ulf J.; Fournier, Eric J.-L.; Hindsgaul, Ole
1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase
score: 1.7674484, Bioorganic & Medicinal Chemistry Letters, 2012, Yacovan, Avihai et. al.
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS)
score: 1.767224, Bioorganic & Medicinal Chemistry Letters, 2012, Annedi, Subhash C. et. al.
Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives with in vivo hypnotic and analgesic profile
score: 1.7670745, Bioorganic & Medicinal Chemistry, 2006, Menegatti, Ricardo et. al.
Structure-Based Discovery of C-2 Substituted Imidazo-pyrrolopyridine JAK1 Inhibitors with Improved Selectivity over JAK2
score: 1.7668642, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid
score: 1.7666619, Bioorganic & Medicinal Chemistry, 1999, Baures, Paul W et. al.
New substituted 4H-chromenes as anticancer agents
score: 1.7663862, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
New substituted 4H-chromenes as anticancer agents
score: 1.7663862, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
New substituted 4H-chromenes as anticancer agents
score: 1.7663862, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity
score: 1.7662959, Bioorganic & Medicinal Chemistry Letters, 2010, Kotoku, Naoyuki et. al.
Synthesis and evaluation of novel potent HCV NS5A inhibitors
score: 1.7662561, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hongwang et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7661042, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7661042, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7661042, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Practical synthesis of all inositol stereoisomers from myo-inositol
score: 1.7659543, Bioorganic & Medicinal Chemistry Letters, 1999, Chung, Sung-Kee; Kwon, Yong-Uk
Design and Synthesis of a Selective EP4-Receptor Agonist. Part 2: 3,7-DithiaPGE 1 Derivatives with High Selectivity
score: 1.7658435, Bioorganic & Medicinal Chemistry, 2002, Maruyama, Toru et. al.
Synthesis and biological evaluation of platinum–acridine hybrid agents modified with bipyridine non-leaving groups
score: 1.7656788, Bioorganic & Medicinal Chemistry Letters, 2009, Kheradi, Alexander R. et. al.
Synthesis of benzamide derivatives and their evaluation as antiprion agents
score: 1.7656079, Bioorganic & Medicinal Chemistry, 2012, Fiorino, Ferdinando et. al.
Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D 3
score: 1.7652773, Bioorganic & Medicinal Chemistry, 2006, Sinishtaj, Sandra et. al.
2-Aminothiophene-3-carboxylates and carboxamides as adenosine A 1 receptor allosteric enhancers
score: 1.7652163, Bioorganic & Medicinal Chemistry, 2006, Nikolakopoulos, George et. al.
A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases
score: 1.7651704, Bioorganic & Medicinal Chemistry Letters, 1999, Mazzucco, Silvia et. al.
Liquid phase parallel synthesis of guanidines
score: 1.764954, Bioorganic & Medicinal Chemistry Letters, 1999, Ko-Chieh Ho, ; Chung-Ming Sun,
Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol
score: 1.7637394, Bioorganic & Medicinal Chemistry Letters, 2012, Hanson, Robert N. et. al.
Formylated polyamines as peptidomimetics
score: 1.7635778, Bioorganic & Medicinal Chemistry Letters, 2012, Javor, Sacha et. al.
Formylated polyamines as peptidomimetics
score: 1.7635778, Bioorganic & Medicinal Chemistry Letters, 2012, Javor, Sacha et. al.
Synthesis, structure–activity relationship and antiviral activity of 3′- N, N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs
score: 1.7633568, European Journal of Medicinal Chemistry, 2010, Singh, Ramendra K. et. al.
Pentacyclic hemiacetal sterol with antifouling and cytotoxic activities from the soft coralNephtheasp.
score: 1.7632702, Bioorganic & Medicinal Chemistry Letters, 2013, Zhang, Jun et. al.
Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α1-adrenoceptor antagonistic properties
score: 1.7630416, Bioorganic & Medicinal Chemistry, 2012, Handzlik, Jadwiga et. al.
Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT 1A receptor agents with anxiolytic- like activity
score: 1.762589, Bioorganic & Medicinal Chemistry, 2006, Bojarski, Andrzej J. et. al.
Shaken not stirred: A facile synthesis of 1,4-bis(furo[2,3- d]-pyrimidine-2,4(1 H,3 H)-dione-5-yl)benzenes by one-pot reaction of isocyanides, N, N′-dimethylbarbituric acid, and terephthaldialdehyde
score: 1.7623845, Bioorganic & Medicinal Chemistry Letters, 2006, Teimouri, Mohammad Bagher; Bazhrang, Reihaneh
Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling
score: 1.7621975, Bioorganic & Medicinal Chemistry, 2004, Pignatello, Rosario et. al.
Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies
score: 1.7621553, Bioorganic & Medicinal Chemistry, 2004, Baraldi, Pier Giovanni et. al.
Structural Studies on Bioactive Compounds. Part 36: Design, Synthesis and Biological Evaluation of Pyrimethamine-Based Antifolates Against Pneumocystis carinii
score: 1.7619509, Bioorganic & Medicinal Chemistry, 2002, Chan, David C.M. et. al.
Design, synthesis and biological evaluation of novel acrylamide analogues as inhibitors of BCR–ABL kinase
score: 1.7619497, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Shuxin et. al.
Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism.
score: 1.7618312, Antimicrobial agents and chemotherapy, 1998, Farnet, C M et. al.
Structure–activity relationships of novel endomorphin-2 analogues with N–O turns induced by α-aminoxy acids
score: 1.761712, Bioorganic & Medicinal Chemistry Letters, 2005, Wei, Jie et. al.
Synthesis and evaluation of antithrombotic activity of benzocoumarin amide derivatives
score: 1.7615333, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors
score: 1.7614013, Bioorganic & Medicinal Chemistry Letters, 2013, Ho, Koc-Kan et. al.
In vitro cytotoxicity of 5-aminosubstituted 20( S)-camptothecins. part 1
score: 1.7613698, Bioorganic & Medicinal Chemistry, 1999, Subrahmanyam, Duvvuri et. al.
Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives
score: 1.7612594, European Journal of Medicinal Chemistry, 2012, Audisio, Davide et. al.
Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives
score: 1.7612594, European Journal of Medicinal Chemistry, 2012, Audisio, Davide et. al.
Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine
score: 1.7612593, Bioorganic & Medicinal Chemistry Letters, 2005, Wentland, Mark P. et. al.
Drugs, leads, and drug-likeness: an analysis of some recently launched drugs
score: 1.7610727, Bioorganic & Medicinal Chemistry Letters, 2002, Proudfoot, John R.
Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
score: 1.7610342, European Journal of Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
score: 1.7610342, European Journal of Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Thieno[3,2-c]pyran-4-one based novel small molecules: their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents
score: 1.7605106, Bioorganic & Medicinal Chemistry Letters, 2012, Nakhi, Ali et. al.
The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer’s disease
score: 1.7603003, Bioorganic & Medicinal Chemistry Letters, 2013, Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang
Discovery of a new binding mode for a series of liver X receptor agonists
score: 1.7601829, Bioorganic & Medicinal Chemistry Letters, 2012, Kopecky, David J. et. al.
Spirocyclopropyl pyrrolidines as a new series of α- l-fucosidase inhibitors
score: 1.7601134, Bioorganic & Medicinal Chemistry, 2006, Laroche, Christophe et. al.
Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors
score: 1.7597664, Bioorganic & Medicinal Chemistry Letters, 2009, Birch, Alan M. et. al.
Design, Synthesis and SAR Analysis of Novel Potent and Selective Small Molecule Antagonists of NPBWR1 (GPR7)
score: 1.7596939, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Investigation on the isoform selectivity of histone deacetylase inhibitors using chemical feature based pharmacophore and docking approaches
score: 1.7596869, European Journal of Medicinal Chemistry, 2010, Zhu, Yong et. al.
Chlorin e6–cholesterol conjugate and its copper complex. Simple synthesis and entrapping in phospholipid vesicles
score: 1.7596445, Bioorganic & Medicinal Chemistry Letters, 2010, Nikolaeva, Irina A. et. al.
Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: Structure–activity relationships of the 4-anilino group
score: 1.7596055, Bioorganic & Medicinal Chemistry, 2006, Sirisoma, Nilantha et. al.
2-Deoxy-2,3-didehydro- N-acetylneuraminic acid analogues structurally modified at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1
score: 1.7595763, Bioorganic & Medicinal Chemistry, 2006, Ikeda, Kiyoshi et. al.
Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on β-tubulin
score: 1.7590942, Bioorganic & Medicinal Chemistry, 2000, Brown, Milton L; Rieger, Jayson M; Macdonald, Timothy L
Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin
score: 1.7590112, Bioorganic & Medicinal Chemistry, 2006, Hayes, Patricia Y. et. al.
Synthesis and muscarinic activities of 3-(pyrazolyl)-1,2,5,6-tetrahydropyridine derivatives
score: 1.7590068, Bioorganic & Medicinal Chemistry, 1996, Plate, Ralf et. al.
CRHR 1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists
score: 1.7585674, Bioorganic & Medicinal Chemistry, 2002, Hsin, Ling-Wei et. al.
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors
score: 1.7582684, Bioorganic & Medicinal Chemistry Letters, 2012, Parker, Michael F. et. al.
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors
score: 1.7582684, Bioorganic & Medicinal Chemistry Letters, 2012, Parker, Michael F. et. al.
Scaffold hopping strategy towards original pyrazolines as selective CB2 receptor ligands
score: 1.7581738, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance
score: 1.7580509, Bioorganic & Medicinal Chemistry, 2010, Innocenti, Alessio et. al.
Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers
score: 1.7578096, Bioorganic & Medicinal Chemistry Letters, 2006, Gao, Mingzhang et. al.
Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties
score: 1.7572269, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Yan; Ma, Long-Xu; Niu, Tian-Wei; Cui, Xun; Piao, Hu-Ri
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
score: 1.7566258, European Journal of Medicinal Chemistry, 2012, Li, Xue et. al.
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
score: 1.7566258, European Journal of Medicinal Chemistry, 2012, Li, Xue et. al.
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
score: 1.7566258, European Journal of Medicinal Chemistry, 2012, Li, Xue et. al.
Design, synthesis and structure–affinity relationships of 4-methylidenepiperidine and 4-aryl-1,2,3,6-tetrahydropyridine derivatives as corticotropin-releasing factor 1 receptor antagonists
score: 1.7565502, Bioorganic & Medicinal Chemistry, 2000, Nakazato, Atsuro et. al.
Structure–activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure
score: 1.7560996, Bioorganic & Medicinal Chemistry, 2004, Kawanishi, Motoyuki et. al.
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides
score: 1.7559374, Bioorganic & Medicinal Chemistry, 2012, Baruah, Pranjal K. et. al.
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides
score: 1.7559374, Bioorganic & Medicinal Chemistry, 2012, Baruah, Pranjal K. et. al.
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides
score: 1.7559374, Bioorganic & Medicinal Chemistry, 2012, Baruah, Pranjal K. et. al.
In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates.
score: 1.7557905, Antimicrobial agents and chemotherapy, 2011, Suzuki, Takashi et. al.
Allylic thiocyanates as a new class of antitubercular agents
score: 1.7557115, Bioorganic & Medicinal Chemistry Letters, 2012, Silveira, Gustavo P. et. al.
Synthesis and pharmacology of a hybrid cannabinoid
score: 1.7556637, Bioorganic & Medicinal Chemistry, 2000, Huffman, John W. et. al.
Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2,5-disubstituted-8-quinolinamines and some of their amino acid conjugates
score: 1.7556424, Bioorganic & Medicinal Chemistry, 2004, Jain, Meenakshi et. al.
Synthesis and pharmacological evaluation of 5 H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents
score: 1.7555529, Bioorganic & Medicinal Chemistry, 2004, Bruno, Olga et. al.
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
score: 1.7553478, European Journal of Medicinal Chemistry, 2012, Bertinaria, Massimo et. al.
The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents
score: 1.7552269, European Journal of Medicinal Chemistry, 2012, Wang, Lei et. al.
Technetium-99m-labeling and synthesis of thymidine analogs: Potential candidates for tumor imaging
score: 1.7548968, Bioorganic & Medicinal Chemistry Letters, 2007, Teng, Bao et. al.
Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors
score: 1.7546816, Bioorganic & Medicinal Chemistry, 1998, Hinterding, Klaus et. al.
Chemoinformatics: a view of the field and current trends in method development
score: 1.7546221, Bioorganic & Medicinal Chemistry, 2012, Vogt, Martin; Bajorath, Jürgen
Synthesis and biological evaluation of novel PDMP analogues
score: 1.7543864, Bioorganic & Medicinal Chemistry, 2006, Hillaert, Ulrik et. al.
Synthesis and antimicrotubule activity of combretatropone derivatives
score: 1.7539364, Bioorganic & Medicinal Chemistry, 2002, Janik, Mark E.; Bane, Susan L.
Benzamides and benzamidines as specific inhibitors of epidermal growth factor receptor and v-Src protein tyrosine kinases
score: 1.7538199, Bioorganic & Medicinal Chemistry, 2004, Asano, Toru et. al.
A very simple synthesis of GlcNAc-α-pyrophosphoryl-decanol: A substrate for the assay of a bacterial galactosyltransferase
score: 1.7536896, Bioorganic & Medicinal Chemistry Letters, 2008, Brockhausen, Inka; Larsson, E. Andreas; Hindsgaul, Ole
Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
score: 1.7536706, Bioorganic & Medicinal Chemistry Letters, 2012, Mohan, Sahoo Biswa et. al.
Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
score: 1.7536706, Bioorganic & Medicinal Chemistry Letters, 2012, Mohan, Sahoo Biswa et. al.
Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
score: 1.7536706, Bioorganic & Medicinal Chemistry Letters, 2012, Mohan, Sahoo Biswa et. al.
Synthesis and Antitumor Evaluation of Novel Benzo[d]pyrrolo[2,1-b]thiazole Derivatives
score: 1.753623, European Journal of Medicinal Chemistry, 2012, Chaniyara, Ravi et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.753398, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
score: 1.752382, Bioorganic & Medicinal Chemistry Letters, 2012, Yen, Chiao-Ting et. al.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
score: 1.752382, Bioorganic & Medicinal Chemistry Letters, 2012, Yen, Chiao-Ting et. al.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
score: 1.752382, Bioorganic & Medicinal Chemistry Letters, 2012, Yen, Chiao-Ting et. al.
Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI)
score: 1.7521121, Bioorganic & Medicinal Chemistry, 2005, Bondebjerg, Jon et. al.
Synthesis of a BSA-Le x glycoconjugate and recognition of Le x analogues by the anti-Le x monoclonal antibody SH1: The identification of a non-cross reactive analogue
score: 1.7519096, Bioorganic & Medicinal Chemistry, 2010, Wang, Jo-Wen; Asnani, Ari; Auzanneau, France-Isabelle
Discovery of XL413, a potent and selective CDC7 inhibitor
score: 1.7517568, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.7515503, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Hybrid stereoisomers of a compact molecular probe based on a jasmonic acid glucoside: Syntheses and biological evaluations
score: 1.7512475, Bioorganic & Medicinal Chemistry, 2012, Ueda, Minoru et. al.
Synthesis and structural study of cyclic 5-aminovaleric acid-linked β-Ala–β-Ala dipeptides
score: 1.7512425, Bioorganic & Medicinal Chemistry Letters, 2008, Mengel, Anne; Reiser, Oliver; Aubé, Jeffrey
Structure–activity relationships for 1′,1′-dimethylalkyl-Δ 8-tetrahydrocannabinols
score: 1.7510097, Bioorganic & Medicinal Chemistry, 2003, Huffman, John W et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7507369, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Synthesis and anticancer activity of benzyloxybenzaldehyde derivatives against HL-60 cells
score: 1.7507164, Bioorganic & Medicinal Chemistry, 2005, Lin, Chin-Fen et. al.
Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues
score: 1.7507123, Bioorganic & Medicinal Chemistry, 2005, Silva, Alexandre G. et. al.
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands
score: 1.7506894, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors
score: 1.7506735, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)
score: 1.7506178, Bioorganic & Medicinal Chemistry Letters, 2013, Martínez-Botella, Gabriel et. al.
Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases
score: 1.7504264, Bioorganic & Medicinal Chemistry Letters, 2012, Plé, Patrick A. et. al.
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
score: 1.7503542, European Journal of Medicinal Chemistry, 2012, Zhang, Lei et. al.
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
score: 1.7503542, European Journal of Medicinal Chemistry, 2012, Zhang, Lei et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.7503292, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds.
score: 1.7503124, Antimicrobial agents and chemotherapy, 2004, Cushion, Melanie T et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7501797, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7501797, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7501797, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
Synthesis and evaluation of a 99mTc-BAT-phenylbenzothiazole conjugate as a potential in vivo tracer for visualization of amyloid β
score: 1.7501668, Bioorganic & Medicinal Chemistry Letters, 2007, Serdons, K. et. al.
Parallel solid-phase synthesis of vitronectin receptor (αvβ3) inhibitors
score: 1.750082, Bioorganic & Medicinal Chemistry Letters, 2000, Gopalsamy, Ariamala et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7500251, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7500251, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7500251, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Structure-based design, synthesis, and in vitro assay of novel nucleoside analog inhibitors against HIV-1 reverse transcriptase
score: 1.7499348, Bioorganic & Medicinal Chemistry Letters, 2005, Liu, Xianjun; Xie, Wei; Huang, Raven H.
A structure–activity study of spermicidal and anti-HIV properties of hydroxylated cationic surfactants
score: 1.7497662, Bioorganic & Medicinal Chemistry, 2002, Wong, Yue-Ling et. al.
Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors
score: 1.749681, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Kai et. al.
The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment
score: 1.749571, European Journal of Medicinal Chemistry, 2012, Kantsadi, A.L. et. al.
Synthesis of indolylalkoxyiminoalkylcarboxylates as leukotriene biosynthesis inhibitors
score: 1.7495633, Bioorganic & Medicinal Chemistry, 1997, Kolasa, Teodozyj et. al.
Heterocyclic rimantadine analogues with antiviral activity
score: 1.7494542, Bioorganic & Medicinal Chemistry, 2003, Stamatiou, George et. al.
Synthesis of novel cyclic NGR/RGD peptide analogs via on resin click chemistry
score: 1.7494139, Bioorganic & Medicinal Chemistry Letters, 2010, Metaferia, Belhu B. et. al.
Synthesis and antitumor activity of formononetin nitrogen mustard derivatives
score: 1.7493666, European Journal of Medicinal Chemistry, 2012, Ren, Jie et. al.
A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
score: 1.7492363, European Journal of Medicinal Chemistry, 2012, Venkateswararao, Eeda et. al.
Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA A receptor complex
score: 1.7490575, Bioorganic & Medicinal Chemistry, 2001, Marder, Mariel et. al.
Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives
score: 1.7487761, Bioorganic & Medicinal Chemistry Letters, 2012, Saito, Yoshio et. al.
Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives
score: 1.7487219, European Journal of Medicinal Chemistry, 2013, Shakil, N.A. et. al.
Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives
score: 1.7487219, European Journal of Medicinal Chemistry, 2013, Shakil, N.A. et. al.
Facile synthesis of novel mutual derivatives of nucleosides and pyrimidines by regioselectively chemo-enzymatic protocol
score: 1.748716, Bioorganic & Medicinal Chemistry, 2008, Qian, Xueqi; Liu, Bokai; Wu, Qi; Lv, Deshui; Lin, Xian-Fu
Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4
score: 1.7481881, Bioorganic & Medicinal Chemistry Letters, 2012, Bhaskar Kumar, T. et. al.
Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells’ activity
score: 1.7480803, Bioorganic & Medicinal Chemistry, 2006, Tanabe, Takamasa et. al.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 1.7480174, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 1.7480174, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
Triazoloamides as potent γ-secretase modulators with reduced hERG liability
score: 1.7479026, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Triazoloamides as potent γ-secretase modulators with reduced hERG liability
score: 1.7479026, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Triazoloamides as potent γ-secretase modulators with reduced hERG liability
score: 1.7479026, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Synthesis and anticonvulsant evaluation of some new 2-substituted-3-arylpyrido[2,3- d]pyrimidinones
score: 1.7478143, Bioorganic & Medicinal Chemistry, 2004, White, David C. et. al.
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies
score: 1.7476865, Bioorganic & Medicinal Chemistry, 2006, Gerpe, Alejandra et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.7475064, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
Synthesis and biological activity of N, N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives
score: 1.7473237, Bioorganic & Medicinal Chemistry, 2006, Braña, Miguel F. et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Synthesis and antiproliferative activity of basic thioanalogues of merbarone
score: 1.7468123, Bioorganic & Medicinal Chemistry, 2003, Ranise, Angelo et. al.
Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates
score: 1.7467866, Bioorganic & Medicinal Chemistry, 2008, Fujita, Yoshio et. al.
Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues
score: 1.7464766, Bioorganic & Medicinal Chemistry, 2006, Aoyagi, Yutaka et. al.
6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents
score: 1.7464622, Bioorganic & Medicinal Chemistry, 2006, Lin, Chun-Mao et. al.
Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives
score: 1.7464499, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives
score: 1.7464499, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives
score: 1.7464499, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Pyrenyldiazomethane, a versatile reagent for nucleotide phosphate alkylation
score: 1.7459961, Bioorganic & Medicinal Chemistry Letters, 2005, Kotera, Mitsuharu et. al.
Synthesis of highly water-soluble fibrate derivatives via BGLation
score: 1.7458258, Bioorganic & Medicinal Chemistry Letters, 2012, Nemoto, Hisao et. al.
Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies
score: 1.7455564, Bioorganic & Medicinal Chemistry Letters, 2010, Sun, Chuanwen et. al.
Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogues of quercetin as thrombin inhibitors
score: 1.7454353, European Journal of Medicinal Chemistry, 2012, Shi, Zhi-Hao et. al.
Structure–activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators
score: 1.745419, Bioorganic & Medicinal Chemistry, 2013, Mita, Yusuke et. al.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
score: 1.7453726, Antimicrobial agents and chemotherapy, 2012, Summa, Vincenzo et. al.
Identification of optimum computational protocols for modeling the aryl hydrocarbon receptor (AHR) and its interaction with ligands
score: 1.7451736, Bioorganic & Medicinal Chemistry Letters, 2010, Jogalekar, Ashutosh S.; Reiling, Stephan; Vaz, Roy J.
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold
score: 1.7450956, Bioorganic & Medicinal Chemistry, 2012, Morera, Ludovica et. al.
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold
score: 1.7450956, Bioorganic & Medicinal Chemistry, 2012, Morera, Ludovica et. al.
Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine receptor
score: 1.7450436, Bioorganic & Medicinal Chemistry, 2012, Nishiwaki, Hisashi et. al.
Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine receptor
score: 1.7450436, Bioorganic & Medicinal Chemistry, 2012, Nishiwaki, Hisashi et. al.
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1 H-pyrazolo[3,4- d]pyrimidines 4-amino substituted and their biological evaluation
score: 1.7450378, European Journal of Medicinal Chemistry, 2004, Schenone, Silvia et. al.
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists
score: 1.7449327, Bioorganic & Medicinal Chemistry, 2013, Yamamoto, Satoshi et. al.
Three-Dimensional molecular-Field analyses of octopaminergic agonists for the cockroach neuronal octopamine receptor
score: 1.7447733, Bioorganic & Medicinal Chemistry, 2003, Hirashima, Akinori et. al.
Discovery of XL413, a potent and selective CDC7 inhibitor
score: 1.7445099, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Discovery of XL413, a potent and selective CDC7 inhibitor
score: 1.7445099, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Synthesis and transfecting properties of a glycosylated polycationic DNA vector 1
score: 1.7443442, Bioorganic & Medicinal Chemistry Letters, 2001, Jacopin, Christophe et. al.
Synthesis and anti-inflammatory evaluations of β-lapachone derivatives
score: 1.7442966, Bioorganic & Medicinal Chemistry, 2013, Tseng, Chih-Hua et. al.
Synthesis, biological evaluation, and molecular docking studies of Benzyl, Alkyl and Glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as Potential Immunomodulatory and Immunosuppressive Agents
score: 1.7440921, Bioorganic & Medicinal Chemistry, 2012, El Ashry, El Sayed H. et. al.
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation
score: 1.7440066, Bioorganic & Medicinal Chemistry Letters, 2012, Radi, Marco et. al.
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease
score: 1.743777, Bioorganic & Medicinal Chemistry Letters, 2012, Al-Baghdadi, Osamah et. al.
Synthesis, characterization, and anticonvulsant activity of enaminones. Part 5: Investigations on 3-carboalkoxy-2-methyl-2,3-dihydro-1 H-phenothiazin-4[10 H]-one derivatives
score: 1.7436662, Bioorganic & Medicinal Chemistry, 1998, Laws, Mia L. et. al.
5 H-Dibenzo[ c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-Targeting anticancer agents with potent cytotoxic activity
score: 1.7435935, Bioorganic & Medicinal Chemistry, 2003, Ruchelman, Alexander L. et. al.
Natural Products as a Gold Mine for Selective Matrix Metalloproteinases Inhibitors
score: 1.7435315, Bioorganic & Medicinal Chemistry, 2012, Wang, Liyan et. al.
Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity
score: 1.7433938, European Journal of Medicinal Chemistry, 2012, Skiba, Joanna et. al.
Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity
score: 1.7433938, European Journal of Medicinal Chemistry, 2012, Skiba, Joanna et. al.
The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis x
score: 1.7432352, Bioorganic & Medicinal Chemistry, 1998, Murphy, Paul V. et. al.
Design, synthesis, and evaluation of novel 2-substituted-4-aryl-6,7,8,9-tetrahydro-5 H-pyrimido[4,5- b][1,5]oxazocin-5-ones as NK 1 antagonists
score: 1.7429219, Bioorganic & Medicinal Chemistry, 2005, Seto, Shigeki; Tanioka, Asao; Ikeda, Makoto; Izawa, Shigeru
Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with β-secretase
score: 1.7428934, Bioorganic & Medicinal Chemistry, 2005, Zuo, Zhili et. al.
Prediction of oral bioavailability by adaptive fuzzy partitioning
score: 1.7428858, European Journal of Medicinal Chemistry, 2003, Pintore, Marco et. al.
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
score: 1.7427573, Bioorganic & Medicinal Chemistry, 2012, Misawa, Takashi et. al.
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
score: 1.7427573, Bioorganic & Medicinal Chemistry, 2012, Misawa, Takashi et. al.
Microwave-assisted synthesis of antimicrobial dihydropyridines and tetrahydropyrimidin-2-ones: Novel compounds against aspergillosis
score: 1.7426504, Bioorganic & Medicinal Chemistry, 2006, Chhillar, Anil K. et. al.
Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V 1A receptor
score: 1.7426284, Bioorganic & Medicinal Chemistry, 2006, Shimada, Yoshiaki et. al.
Synthesis, crystal structures, in vitro biological evaluation of zinc(II) and bismuth(III) complexes of 2-acetylpyrazine N(4)-phenylthiosemicarbazone
score: 1.7426184, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Ming-Xue et. al.
Rotational deviation of 3-acetyl group from cyclic tetrapyrrole π-plane in synthetic bacteriochlorophyll- a analogs by 20-substitution
score: 1.7425295, Bioorganic & Medicinal Chemistry Letters, 2008, Tamiaki, Hitoshi; Kotegawa, Yuki; Mizutani, Keisuke
Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase
score: 1.7425107, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, In-Hae et. al.
Efficient approach to acyloxymethyl esters of nalidixic acid and in vitro evaluation as intra-ocular prodrugs
score: 1.7423895, Bioorganic & Medicinal Chemistry, 2006, Azéma, Joëlle et. al.
Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells
score: 1.7423199, Bioorganic & Medicinal Chemistry Letters, 2013, Miyata, Yoshiki et. al.
Synthesis and antifungal activity of substituted-10-methyl-1,2,3,4-tetrahydropyrazino[1,2- a]indoles
score: 1.7420433, Bioorganic & Medicinal Chemistry, 2006, Tiwari, Rakesh Kumar et. al.
Synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers
score: 1.7419054, Bioorganic & Medicinal Chemistry, 1998, Takahashi, Tadakatsu et. al.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
score: 1.7417264, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
score: 1.7417264, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
score: 1.7417264, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives
score: 1.7416602, Bioorganic & Medicinal Chemistry, 2004, Mäntylä, Antti et. al.
Design, syntheses, and biological evaluations of squamostolide and its related analogs
score: 1.7414614, Bioorganic & Medicinal Chemistry, 2005, Lee, Cheng-Lin et. al.
New potential biologically active compounds: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1 H,3 H)-diones under microwave irradiation
score: 1.741267, Bioorganic & Medicinal Chemistry Letters, 2006, Tu, Shujiang et. al.
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain
score: 1.7409225, Bioorganic & Medicinal Chemistry Letters, 2012, Jiao, Guan-Sheng et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.7407764, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
Novel retinoid X receptor (RXR) antagonists having a dicarba- closo-dodecaborane as a hydrophobic moiety
score: 1.7406401, Bioorganic & Medicinal Chemistry Letters, 2004, Ohta, Kiminori et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 1.7404964, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Synthesis and bioactivity of 2,4-diacyl analogues of paclitaxel
score: 1.7404115, Bioorganic & Medicinal Chemistry, 2001, Chordia, Mahendra D et. al.
Sulfonamide bearing oligonucleotides: Simple synthesis and efficient RNA recognition
score: 1.7403514, Bioorganic & Medicinal Chemistry, 2012, Kumar, Pawan et. al.
Challenges of antibacterial discovery.
score: 1.7403377, Clinical microbiology reviews, 2011, Silver, Lynn L
Prediction of intrinsic solubility of generic drugs using MLR, ANN and SVM analyses
score: 1.7400191, European Journal of Medicinal Chemistry, 2010, Louis, Bruno; Agrawal, Vijay K.; Khadikar, Padmakar V.
Synthesis and in vitro antitubercular activity of 4-aryl/alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis
score: 1.7398626, Bioorganic & Medicinal Chemistry Letters, 2012, Jeyachandran, Malaichamy et. al.
Synthesis and in vitro antitubercular activity of 4-aryl/alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis
score: 1.7398626, Bioorganic & Medicinal Chemistry Letters, 2012, Jeyachandran, Malaichamy et. al.
Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.
score: 1.7395148, Antimicrobial agents and chemotherapy, 2012, Pou, Sovitj et. al.
Design, Synthesis, and Structure-activity Relationships of Novel Spiro-piperidines as Acetyl-CoA Carboxylase Inhibitors
score: 1.73941, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
5-Alkylated thiazolidinones as follicle-stimulating hormone (FSH) receptor agonists
score: 1.7393831, Bioorganic & Medicinal Chemistry, 2006, Wrobel, Jay et. al.
A Facile One-Pot Synthesis of 4,5-Diaryl-2,2-dimethyl-3( 2H)-furanones
score: 1.7381475, Bioorganic & Medicinal Chemistry, 2002, Lee, Ki-Wha et. al.
Discovery of selective, small-molecule inhibitors of RNA complexes—1. The tat protein/TAR RNA complexes required for HIV-1 transcription
score: 1.7379093, Bioorganic & Medicinal Chemistry, 1997, Mei, Houng-Yau et. al.
Conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site
score: 1.737681, Bioorganic & Medicinal Chemistry, 2012, Varvarigou, Nicole et. al.
Conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site
score: 1.737681, Bioorganic & Medicinal Chemistry, 2012, Varvarigou, Nicole et. al.
Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H 37 Rv
score: 1.7374391, Bioorganic & Medicinal Chemistry Letters, 2005, Shindikar, Anand V.; Viswanathan, C.L.
Discovery and preliminary structure–activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds
score: 1.7374143, Bioorganic & Medicinal Chemistry Letters, 2013, Liew, Lydia P.P.; Kaiser, Marcel; Copp, Brent R.
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
score: 1.7373027, Bioorganic & Medicinal Chemistry Letters, 2012, Chapman, Timothy M. et. al.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d] pyrimidine derivatives
score: 1.7370237, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.
score: 1.7369383, Antimicrobial agents and chemotherapy, 2009, Yang, Liang et. al.
Design of β-carboline derivatives as DNA-targeting antitumor agents
score: 1.7367589, European Journal of Medicinal Chemistry, 2006, Guan, Huaji et. al.
Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents
score: 1.736666, Bioorganic & Medicinal Chemistry Letters, 2012, Chae, Eunhee et. al.
Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.
score: 1.7366536, Antimicrobial agents and chemotherapy, 2012, Ke, Wei et. al.
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7366352, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7366352, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7366352, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
score: 1.7366228, Bioorganic & Medicinal Chemistry Letters, 2012, McLean, Larry R. et. al.
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
score: 1.7366228, Bioorganic & Medicinal Chemistry Letters, 2012, McLean, Larry R. et. al.
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
score: 1.7366228, Bioorganic & Medicinal Chemistry Letters, 2012, McLean, Larry R. et. al.
[4-[[ N-(3-Chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors
score: 1.7365832, Bioorganic & Medicinal Chemistry, 2000, Tumiatti, Vincenzo et. al.
Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases
score: 1.7361049, Bioorganic & Medicinal Chemistry, 2004, Götz, Marion G. et. al.
Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties
score: 1.7361013, Bioorganic & Medicinal Chemistry, 2006, Bezerra-Netto, Heleno J.C. et. al.
New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity.
score: 1.7358736, Antimicrobial agents and chemotherapy, 2004, Beyer, Dieter et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs
score: 1.7352774, Bioorganic & Medicinal Chemistry Letters, 2009, Simon, Grégory et. al.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure–activity relationships of neocryptolepines and 6-methyl congeners
score: 1.7352768, Bioorganic & Medicinal Chemistry, 2012, Wang, Li et. al.
Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
score: 1.7350039, Bioorganic & Medicinal Chemistry, 2005, Komoriya, Satoshi et. al.
Synthesis and biological activity of bi/tricyclic azasugars fused thiazolidin-4-one and thiazinan-4-one by microwave-assisted tandem Staudinger/aza-Wittig/cyclization
score: 1.7349016, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xiaoliu et. al.
QSAR study on some anti-HIV HEPT analogues using physicochemical and topological parameters
score: 1.73485, Bioorganic & Medicinal Chemistry, 2004, Gayen, Shovanlal; Debnath, Bikash; Samanta, Soma; Jha, Tarun
Synthesis and structure–activity relationship of a novel class of 15-membered macrolide antibiotics known as ‘11a-azalides’
score: 1.7344102, Bioorganic & Medicinal Chemistry, 2012, Sugimoto, Tomohiro et. al.
Synthesis of 17β-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines
score: 1.7341463, Bioorganic & Medicinal Chemistry Letters, 2008, Provencher-Mandeville, Josée et. al.
Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity
score: 1.7332916, Bioorganic & Medicinal Chemistry, 2012, Chen, Kuen-Feng et. al.
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol
score: 1.7330355, Bioorganic & Medicinal Chemistry, 2012, Cho, Suengmok et. al.
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
score: 1.7328877, Bioorganic & Medicinal Chemistry Letters, 2012, Bruce, Ian et. al.
A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives.
score: 1.7328424, Antimicrobial agents and chemotherapy, 2011, Burger-Kentischer, Anke et. al.
2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain
score: 1.7327271, Bioorganic & Medicinal Chemistry, 1996, Baillet, Stéphanie et. al.
Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities
score: 1.7326453, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Jian et. al.
Enzymatic syntheses and selective hydrolysis of O-β- d-galactopyranosides using a marine mollusc β-galactosidase
score: 1.7324055, Bioorganic & Medicinal Chemistry Letters, 2005, Giordano, Assunta et. al.
Cyclic Dibenzoylhydrazines Reproducing the Conformation of Ecdysone Agonists, RH-5849
score: 1.7323749, Bioorganic & Medicinal Chemistry, 2002, Toya, Tetsuya; Yamaguchi, Kentaro; Endo, Yasuyuki
Enamino-oxindole HIV protease inhibitors
score: 1.7322606, Bioorganic & Medicinal Chemistry Letters, 2012, Eissenstat, Michael et. al.
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine.
score: 1.7321772, Antimicrobial agents and chemotherapy, 2000, Bazmi, H Z et. al.
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
score: 1.7321032, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Li et. al.
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
score: 1.7321032, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Li et. al.
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
score: 1.7321032, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Li et. al.
Phosphoramidate and phosphate prodrugs of (−)-β- d-(2 R,4 R)-dioxolane-thymine: Synthesis, anti-HIV activity and stability studies
score: 1.7320537, Bioorganic & Medicinal Chemistry, 2006, Liang, Yuzeng et. al.
Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid
score: 1.7318834, Bioorganic & Medicinal Chemistry Letters, 2009, Cao, Hongzhi et. al.
Design, syntheses, and structure–Activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads
score: 1.7316211, Bioorganic & Medicinal Chemistry, 2001, Morimoto, Hiroshi et. al.
Efficient synthesis and biological evaluation of all a-ring diastereomers of 1α,25-dihydroxyvitamin D 3 and its 20-epimer
score: 1.7313557, Bioorganic & Medicinal Chemistry, 2000, Fujishima, Toshie et. al.
Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives
score: 1.7309929, European Journal of Medicinal Chemistry, 2012, Maggio, B. et. al.
Enamino-oxindole HIV protease inhibitors
score: 1.730979, Bioorganic & Medicinal Chemistry Letters, 2012, Eissenstat, Michael et. al.
Synthesis and structure–activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells
score: 1.730779, Bioorganic & Medicinal Chemistry, 2002, Ogita, Haruhisa et. al.
Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: potential PET imaging agents for tumor detection
score: 1.7306093, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yurong et. al.
Design, synthesis and evaluation of a series of novel fumagillin analogues
score: 1.7305023, Bioorganic & Medicinal Chemistry, 2003, Fardis, Maria et. al.
Synthesis and antiproliferative activity of some new DNA-targeted alkylating pyrroloquinolines
score: 1.7304777, Bioorganic & Medicinal Chemistry, 2004, Ferlin, M.G.; Dalla Via, L.; Gia, O.M.
Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies
score: 1.7304315, Bioorganic & Medicinal Chemistry Letters, 2010, Niu, Chuansheng et. al.
Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents
score: 1.7302352, Bioorganic & Medicinal Chemistry, 2005, Agarwal, Anu et. al.
Alkylation of succinates: Synthesis of Ro 32–3555
score: 1.7302244, Bioorganic & Medicinal Chemistry Letters, 1998, McClure, Kim F.; Axt, Matthew Z.
Recent advances in the biology and chemistry of the flavaglines
score: 1.7300409, Bioorganic & Medicinal Chemistry, 2012, Ribeiro, Nigel et. al.
Synthesis of highly functionalised dibenzylglycine derivatives via the Suzuki–Miyaura coupling reaction
score: 1.7299596, Bioorganic & Medicinal Chemistry Letters, 2002, Kotha, Sambasivarao et. al.
Diphenyl quinolines and isoquinolines: synthesis and primary biological evaluation
score: 1.7298111, Bioorganic & Medicinal Chemistry, 2000, Croisy-Delcey, Martine et. al.
N-Terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding
score: 1.7297585, Bioorganic & Medicinal Chemistry, 2001, Burke Jr, Terrence R et. al.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives
score: 1.729748, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Synthesis and in vitro and in vivo anticancer activity of novel 3-methyl-5H-isoxazolo[5′,4′:5,6]pyrido[2,3-b]indoles
score: 1.7296662, Bioorganic & Medicinal Chemistry Letters, 2012, Rajanarendar, E. et. al.
Conformationally restricted novel pyrazole derivatives: Synthesis of 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles as a new class of PDE4 inhibitors
score: 1.7293046, Bioorganic & Medicinal Chemistry Letters, 2012, Shyamsunder Reddy, T. et. al.
Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation
score: 1.7292725, Bioorganic & Medicinal Chemistry, 2008, Obika, Satoshi et. al.
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
score: 1.7291149, Bioorganic & Medicinal Chemistry Letters, 2013, Le, Uyen et. al.
Synthesis and biological activity of β-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT
score: 1.7288976, Bioorganic & Medicinal Chemistry, 1997, de Bont, Dries B.A. et. al.
Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes
score: 1.7287752, Bioorganic & Medicinal Chemistry, 2005, Goto, Tokuhito et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.7285756, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.7285756, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
QSAR modeling of HIV-1 reverse transcriptase inhibitor 2-amino-6-arylsulfonylbenzonitriles and congeners using molecular connectivity and E-state parameters
score: 1.7285185, Bioorganic & Medicinal Chemistry, 2004, Roy, Kunal; Leonard, J.Thomas
Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moiety
score: 1.7283298, Bioorganic & Medicinal Chemistry Letters, 2012, Animati, Fabio et. al.
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
score: 1.7281427, Bioorganic & Medicinal Chemistry, 2012, Kambe, Tohru et. al.
Synthesis of C-6 substituted pyrazolo[1,5- a]pyridines with potent activity against herpesviruses
score: 1.7279722, Bioorganic & Medicinal Chemistry, 2006, Allen, Scott H. et. al.
Structure–activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists
score: 1.727968, Bioorganic & Medicinal Chemistry, 2012, Rikimaru, Kentaro et. al.
A Convenient Synthetic Method of a 5,7-Diarylcyclopenteno-[1,2- b]pyridine-6-carboxylate: A Key Intermediate for Potent Endothelin Receptor Antagonists
score: 1.7276333, Bioorganic & Medicinal Chemistry, 2002, Niiyama, Kenji et. al.
Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents
score: 1.7275987, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents
score: 1.7275987, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents
score: 1.7275987, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Novel iodine-124 labeled EGFR inhibitors as potential PET agents for molecular imaging in cancer
score: 1.7275466, Bioorganic & Medicinal Chemistry, 2004, Shaul, Mazal et. al.
Discovery of small molecule HIV-1 integrase dimerization inhibitors
score: 1.7272727, Bioorganic & Medicinal Chemistry Letters, 2012, Tintori, Cristina et. al.
Discovery of small molecule HIV-1 integrase dimerization inhibitors
score: 1.7272727, Bioorganic & Medicinal Chemistry Letters, 2012, Tintori, Cristina et. al.
Discovery of small molecule HIV-1 integrase dimerization inhibitors
score: 1.7272727, Bioorganic & Medicinal Chemistry Letters, 2012, Tintori, Cristina et. al.
Progress in arylpiperazine synthesis by the catalytic amination reaction
score: 1.7271967, Bioorganic & Medicinal Chemistry, 2002, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
score: 1.7269969, Bioorganic & Medicinal Chemistry, 2012, Wang, Yan-Xiang et. al.
Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
score: 1.7269969, Bioorganic & Medicinal Chemistry, 2012, Wang, Yan-Xiang et. al.
Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
score: 1.7269969, Bioorganic & Medicinal Chemistry, 2012, Wang, Yan-Xiang et. al.
In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.
score: 1.7269661, Antimicrobial agents and chemotherapy, 2011, Leeds, J A et. al.
Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors
score: 1.7267593, European Journal of Medicinal Chemistry, 2012, Hao, Lan-hu et. al.
Design, synthesis and molecular docking studies of sinomenine derivatives
score: 1.7266616, Bioorganic & Medicinal Chemistry Letters, 2012, Chai, Xiaoyun et. al.
Enantioselective synthesis of derivatives and structure–activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent
score: 1.7265523, Bioorganic & Medicinal Chemistry Letters, 2013, Kawasaki, Ken-ichi et. al.
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives
score: 1.7262132, Bioorganic & Medicinal Chemistry, 2005, Nakagawa-Goto, Kyoko et. al.
Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide
score: 1.7261763, European Journal of Medicinal Chemistry, 2012, Deslandes, Sébastien et. al.
A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A 2
score: 1.725854, European Journal of Medicinal Chemistry, 2001, Bernard, Philippe et. al.
Novel matrix metalloproteinase inhibitors: Generation of lead compounds by the in silico fragment-based approach
score: 1.7256226, Bioorganic & Medicinal Chemistry, 2005, Takahashi, Kanji et. al.
Synthesis and preliminary biological evaluation of β-carotene and retinoic acid oxidation products
score: 1.725545, Bioorganic & Medicinal Chemistry, 2006, Kithsiri Wijeratne, E.M. et. al.
Synthesis and Evaluation of Novel 2-Pyridone Derivatives as Inhibitors of Phosphodiestarase3 (PDE3): A Target for Heart Failure and Platelet Aggregation
score: 1.7255213, Bioorganic & Medicinal Chemistry Letters, 2012, Ravinder, Mettu et. al.
Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor
score: 1.7254172, Bioorganic & Medicinal Chemistry, 2004, Xu, Yong et. al.
Synthesis and cytotoxic activity of lipophilic sulphonamide derivatives of the benzo[ b]thiophene 1,1-dioxide
score: 1.7252735, Bioorganic & Medicinal Chemistry, 2004, Villar, R. et. al.
Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416
score: 1.7252103, Bioorganic & Medicinal Chemistry, 2006, Pandit, Bulbul et. al.
Non-Natural glycosphingolipids and structurally simpler analogues bind HIV-1 recombinant Gp120
score: 1.7249328, Bioorganic & Medicinal Chemistry, 2002, McReynolds, Katherine D et. al.
Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation
score: 1.7249264, European Journal of Medicinal Chemistry, 2012, Shi, Liqiao et. al.
Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana
score: 1.7247321, Bioorganic & Medicinal Chemistry, 2005, Liaw, Chih-Chuang et. al.
Synthesis and in vitro leishmanicidal activity of some hydrazides and their analogues
score: 1.7244023, Bioorganic & Medicinal Chemistry, 2003, Khan, Khalid Mohammad et. al.
Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity
score: 1.724217, European Journal of Medicinal Chemistry, 2005, Kettler, Katja et. al.
A practical synthesis of 3-[(1 R)-1- t-butyldimethylsilyloxyethyl]-4-[(2 R)-4-halo-3-oxo-2-butyl]azetidinone, a versatile intermediate for carbapenem antibiotics
score: 1.7237923, Bioorganic & Medicinal Chemistry Letters, 1998, Yang, Chunhua; Yasuda, Nobuyoshi
The methymycin/pikromycin pathway: A model for metabolic diversity in natural product biosynthesis
score: 1.7236164, Bioorganic & Medicinal Chemistry, 2009, Kittendorf, Jeffrey D.; Sherman, David H.
Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease
score: 1.7234004, Bioorganic & Medicinal Chemistry, 1998, Badia, Albert et. al.
In silico prediction of central nervous system activity of compounds. Identification of potential pharmacophores by the TOPS–MODE approach
score: 1.7233915, Bioorganic & Medicinal Chemistry, 2004, Cabrera Pérez, Miguel Angel; Sanz, Marival Bermejo
Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)coumarins
score: 1.723167, European Journal of Medicinal Chemistry, 2004, Di Braccio, Mario et. al.
Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
score: 1.7228928, Bioorganic & Medicinal Chemistry Letters, 2012, Yadlapalli, Rama Krishna et. al.
Design, synthesis, and α 1-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion
score: 1.7226708, Bioorganic & Medicinal Chemistry, 2004, Betti, Laura et. al.
Photoactivated DNA cleavage and anticancer activity of pyrenyl-terpyridine lanthanide complexes
score: 1.7225919, European Journal of Medicinal Chemistry, 2012, Hussain, Akhtar et. al.
Molecular docking study and development of an empirical binding free energy model for phosphodiesterase 4 inhibitors
score: 1.7225258, Bioorganic & Medicinal Chemistry, 2006, Oliveira, Fernanda G. et. al.
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents
score: 1.7224119, Bioorganic & Medicinal Chemistry, 2003, Brouillette, Wayne J et. al.
Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists
score: 1.7220606, Bioorganic & Medicinal Chemistry, 2004, Rijkers, Dirk T.S.; den Hartog, Jack A.J.; Liskamp, Rob M.J.
Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry
score: 1.7219639, Bioorganic & Medicinal Chemistry Letters, 2012, Rivara, Mirko et. al.
New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7β-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3′
score: 1.7217055, Bioorganic & Medicinal Chemistry, 2004, Yoshizawa, Hidenori et. al.
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
score: 1.7214219, European Journal of Medicinal Chemistry, 2013, Chuck, Chi-Pang et. al.
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
score: 1.7214219, European Journal of Medicinal Chemistry, 2013, Chuck, Chi-Pang et. al.
Discovery of a new class of ghrelin receptor antagonists
score: 1.7211588, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Quinazolines as adenosine receptor antagonists: SAR and selectivity for A 2B receptors
score: 1.7210622, Bioorganic & Medicinal Chemistry, 2003, Webb, Thomas R et. al.
Synthesis and anti-HIV activity of 1,1,3-trioxo-2 H,4 H-thieno[3,4- e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors
score: 1.7208712, Bioorganic & Medicinal Chemistry, 1999, Arranz, M et. al.
Tridemethylisovelleral, a potent cytotoxic agent
score: 1.7207769, Bioorganic & Medicinal Chemistry, 2005, Aujard, Isabelle et. al.
Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design
score: 1.7206604, Bioorganic & Medicinal Chemistry Letters, 2005, Basak, Amit; Kar, Moumita; Mandal, Subrata
Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration
score: 1.720052, Bioorganic & Medicinal Chemistry Letters, 2013, Ochiai, Koji et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7200454, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Regioselective and stereospecific cleavage of a terminal oxirane system: A novel synthetic approach to lipid mediator congeners—1,2(2,3)-diacyl-3(1)-halo- sn-glycerols
score: 1.7200011, Bioorganic & Medicinal Chemistry Letters, 2006, Stamatov, Stephan D.; Stawinski, Jacek
Fluorescent ligands for adenosine receptors
score: 1.7195468, Bioorganic & Medicinal Chemistry Letters, 2013, Kozma, Eszter et. al.
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: Synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities
score: 1.7194102, European Journal of Medicinal Chemistry, 2012, Kaur, Kirandeep et. al.
Synthesis of 1-(ω-aminoalkyl)naphthoindolediones with antiproliferative properties
score: 1.7193217, Bioorganic & Medicinal Chemistry, 2004, Shchekotikhin, Andrey E et. al.
Organometallic ruthenium(II) complexes: Synthesis, structure and influence of substitution at azomethine carbon towards DNA/BSA binding, radical scavenging and cytotoxicity
score: 1.7193103, European Journal of Medicinal Chemistry, 2012, Sathyadevi, Palanisamy et. al.
Analogs of 1α,25-dihydroxyvitamin D 3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: Synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs
score: 1.719167, Bioorganic & Medicinal Chemistry, 2006, Shimazaki, Mika et. al.
Analogues of antifungal tjipanazoles from rebeccamycin
score: 1.7191598, Bioorganic & Medicinal Chemistry, 2004, Voldoire, Aline et. al.
Enamino-oxindole HIV protease inhibitors
score: 1.7190405, Bioorganic & Medicinal Chemistry Letters, 2012, Eissenstat, Michael et. al.
Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
score: 1.7188418, Bioorganic & Medicinal Chemistry Letters, 2012, Emmadi, Narender Reddy et. al.
Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
score: 1.7188418, Bioorganic & Medicinal Chemistry Letters, 2012, Emmadi, Narender Reddy et. al.
Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
score: 1.7188418, Bioorganic & Medicinal Chemistry Letters, 2012, Emmadi, Narender Reddy et. al.
Selective non-lipid modulator of LPA5 activity in human platelets
score: 1.7188063, Bioorganic & Medicinal Chemistry Letters, 2012, Kozian, Detlef H. et. al.
Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: inhibitors of leukotriene B 4 1 NCL Communication No. 6453. 1
score: 1.7188007, Bioorganic & Medicinal Chemistry, 1999, Deshpande, Anil M. et. al.
Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives
score: 1.7183184, Bioorganic & Medicinal Chemistry, 2006, Chen, Yeh-Long et. al.
Targeting the α-folate receptor with cyclopenta[ g]quinazoline-based inhibitors of thymidylate synthase
score: 1.7182974, Bioorganic & Medicinal Chemistry, 2006, Henderson, Elisa A. et. al.
Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents
score: 1.7182482, Bioorganic & Medicinal Chemistry Letters, 2010, Wang, Limin et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 1.7179947, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds
score: 1.717985, Bioorganic & Medicinal Chemistry, 2003, Dardonville, Christophe et. al.
Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure–activity relationships of phenylpiperazine derivatives
score: 1.7177778, Bioorganic & Medicinal Chemistry, 2006, Takahashi, Toshiyuki et. al.
Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity
score: 1.7176179, Bioorganic & Medicinal Chemistry, 1999, Baraldi, Pier Giovanni et. al.
Inhibition of secretory phospholipase A 2. 2-Synthesis and structure–activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4 H-oxadiazol-5-one ( PMS1062) derivatives specific for group II enzyme
score: 1.7175425, Bioorganic & Medicinal Chemistry, 2005, Dong, Chang-Zhi et. al.
Parallel synthesis and biological activity of a new class of high affinity and selective δ-opioid ligand
score: 1.717535, Bioorganic & Medicinal Chemistry, 2001, Barn, D.R. et. al.
New styryl sulfones as anticancer agents
score: 1.716621, European Journal of Medicinal Chemistry, 2003, Vedula, Manohar Sharma et. al.
The design and synthesis of a potent angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone angiotensin II
score: 1.7165264, Bioorganic & Medicinal Chemistry, 2000, Matsoukas, John M. et. al.
The synthesis and antibacterial activity of totarol derivatives. part 3: modification of ring-B
score: 1.7164844, Bioorganic & Medicinal Chemistry, 2000, Evans, Gary B et. al.
Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents
score: 1.7164056, European Journal of Medicinal Chemistry, 2012, Song, Ming-Xia et. al.
Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents
score: 1.7164056, European Journal of Medicinal Chemistry, 2012, Song, Ming-Xia et. al.
Synthesis and in vitro muscarinic activities of a series of 3-(pyrazol-3-yl)-1-azabicyclo[2.2.2]octanes
score: 1.7163679, Bioorganic & Medicinal Chemistry, 2000, Plate, Ralf et. al.
The antioxidant effect of imine resveratrol analogues
score: 1.7162141, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Jing et. al.
Facile synthesis of cyclopeptide-centered multivalent glycoclusters with ‘click chemistry’ and molecular recognition study by surface plasmon resonance
score: 1.7162069, Bioorganic & Medicinal Chemistry Letters, 2009, Chen, Yong-Xiang et. al.
Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives
score: 1.716197, Bioorganic & Medicinal Chemistry, 2004, Zhu, Xiao-Kang et. al.
Design, synthesis and in vitro characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta cell imaging by SPECT
score: 1.7160669, Bioorganic & Medicinal Chemistry, 2010, Behnam Azad, Babak et. al.
Mechanisms of trovafloxacin hepatotoxicity: Studies of a model cyclopropylamine-containing system
score: 1.7159421, Bioorganic & Medicinal Chemistry Letters, 2007, Sun, Qin; Zhu, Ran; Foss, Frank W.; Macdonald, Timothy L.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
score: 1.7156554, Bioorganic & Medicinal Chemistry, 2012, Chobanian, Harry R. et. al.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
score: 1.7156554, Bioorganic & Medicinal Chemistry, 2012, Chobanian, Harry R. et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7154049, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
1,5-Benzodiazepines
score: 1.715385, European Journal of Medicinal Chemistry, 2002, Grossi, Giancarlo et. al.
Highly solvatochromic fluorescent naphthalimides: Design, synthesis, photophysical properties and fluorescence switch-on sensing of ct-DNA
score: 1.7152496, Bioorganic & Medicinal Chemistry Letters, 2013, Bag, Subhendu Sekhar et. al.
Structure–activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives
score: 1.7152224, Bioorganic & Medicinal Chemistry, 2005, Darvesh, Sultan et. al.
The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency
score: 1.7151575, European Journal of Medicinal Chemistry, 2002, Peschke, Bernd et. al.
A topological sub-structural approach for predicting human intestinal absorption of drugs
score: 1.7151115, European Journal of Medicinal Chemistry, 2004, Pérez, Miguel Angel Cabrera et. al.
Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.
score: 1.7147012, Antimicrobial agents and chemotherapy, 2005, Zhu, Weimin et. al.
Bacterial siderophores: synthesis and biological activities of novel pyochelin analogues
score: 1.7145726, Bioorganic & Medicinal Chemistry Letters, 2003, Zamri, A; Schalk, I.J; Pattus, F; Abdallah, M.A
Multivariate SAR/QSAR of 3-aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase (FAS) inhibitors
score: 1.714442, European Journal of Medicinal Chemistry, 2010, de Melo, Eduardo Borges
Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents
score: 1.7143729, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Yong et. al.
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors
score: 1.7143437, Bioorganic & Medicinal Chemistry Letters, 2013, Mandadapu, Sivakoteswara Rao et. al.
Targeting the gatekeeper residue in phosphoinositide 3-kinases
score: 1.714316, Bioorganic & Medicinal Chemistry, 2005, Alaimo, Peter J.; Knight, Zachary A.; Shokat, Kevan M.
Synthesis and anticancer evaluation of certain 4-anilinofuro[2,3- b]quinoline and 4-anilinofuro[3,2- c]quinoline derivatives
score: 1.714254, European Journal of Medicinal Chemistry, 2005, Chen, Yeh-Long et. al.
Fragmentation of Golgi membranes by norrisolide and designed analogues
score: 1.714171, Bioorganic & Medicinal Chemistry Letters, 2004, Brady, Thomas P. et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7141262, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin.
score: 1.7140808, Antimicrobial agents and chemotherapy, 2003, O'Keefe, Barry R et. al.
The effect of vindoline C-16 substituents on the biomimetic coupling reaction: synthesis and cytotoxicity evalution of the corresponding vinorelbine analogues
score: 1.7140424, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Weibin et. al.
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
score: 1.7140191, Bioorganic & Medicinal Chemistry, 2012, Lang, Karen Luise et. al.
N-Heterocyclic dicarboxylic acids: Broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria
score: 1.7139156, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Lei et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.7138438, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.7138438, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.7138438, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor
score: 1.7138144, Bioorganic & Medicinal Chemistry, 2006, Cohen, Sheila M. et. al.
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice
score: 1.7137595, Bioorganic & Medicinal Chemistry, 2012, Kumar, Atul et. al.
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors
score: 1.7135327, Bioorganic & Medicinal Chemistry, 2005, Stöckel-Maschek, Angela et. al.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 1.7132817, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Baylis–Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
score: 1.712953, Bioorganic & Medicinal Chemistry, 2004, Batra, S. et. al.
Antibacterial activities and characterization of novel inhibitors of LpxC.
score: 1.7128583, Antimicrobial agents and chemotherapy, 2002, Clements, John M et. al.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.7127245, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation
score: 1.7122434, Bioorganic & Medicinal Chemistry, 2012, Mao, Fei et. al.
Catalytic Pictet–Spengler reactions using Yb(OTf) 3
score: 1.7122371, Bioorganic & Medicinal Chemistry, 2005, Manabe, Kei; Nobutou, Daisuke; Kobayashi, Shū
Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation
score: 1.7121943, European Journal of Medicinal Chemistry, 2012, Abdou, Wafaa M.; Barghash, Reham F.; Sediek, Ashraf A.
Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation
score: 1.7121943, European Journal of Medicinal Chemistry, 2012, Abdou, Wafaa M.; Barghash, Reham F.; Sediek, Ashraf A.
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity
score: 1.7120425, European Journal of Medicinal Chemistry, 2012, Karakurt, Arzu et. al.
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity
score: 1.7120425, European Journal of Medicinal Chemistry, 2012, Karakurt, Arzu et. al.
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity
score: 1.7120425, European Journal of Medicinal Chemistry, 2012, Karakurt, Arzu et. al.
Towards a KCC2 blocker pharmacophore model
score: 1.7117926, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Towards a KCC2 blocker pharmacophore model
score: 1.7117926, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Towards a KCC2 blocker pharmacophore model
score: 1.7117926, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Selective boron-Containing thrombin inhibitors—X-ray analysis reveals surprising binding mode
score: 1.7117508, Bioorganic & Medicinal Chemistry, 2000, von Matt, Anette et. al.
Synthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT 4 receptor agonists
score: 1.7117446, Bioorganic & Medicinal Chemistry, 2005, Sonda, Shuji et. al.
N-Acyl-1,2,3,4a,5,10b-hexahydro-[1]benzopyrano-[3,4- b][1,4]oxazine-9-carbonitriles as bladder-selective potassium channel openers
score: 1.7116694, Bioorganic & Medicinal Chemistry, 2001, Chiu, Hsin-I. et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 1.7116674, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
2-Pyrones possessing antimicrobial and cytotoxic activities
score: 1.7115401, Bioorganic & Medicinal Chemistry, 2004, Fairlamb, Ian J.S et. al.
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues
score: 1.7112991, Bioorganic & Medicinal Chemistry, 2006, Krištafor, Vedran et. al.
Inhibition studies with rationally designed inhibitors of the human low molecular weight protein tyrosine phosphatase
score: 1.711222, Bioorganic & Medicinal Chemistry, 2004, Zabell, Adam P.R et. al.
Synthesis, biological evaluation, and molecular modeling of novel thioacridone derivatives related to the anticancer alkaloid acronycine
score: 1.7110629, Bioorganic & Medicinal Chemistry, 2005, Dheyongera, James P. et. al.
An approach for differentiating isozymes. Construction oflibraries containing short aromatic peptides as part of a method to design selective inhibitors against lipases
score: 1.7107812, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sangeun; Yu, Jaehoon
A prenylbisabolane with NF-κB inhibiting properties from Cascarilla ( Croton eluteria)
score: 1.7107584, Bioorganic & Medicinal Chemistry, 2005, Campagnuolo, Claudio et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7105852, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Synthesis and evaluation of N1/C4-substituted β-lactams as PPE and HLE inhibitors
score: 1.7103613, Bioorganic & Medicinal Chemistry, 2004, Gérard, Stéphane et. al.
Lipophilic antifolate trimetrexate is a potent inhibitor of Trypanosoma cruzi: prospect for chemotherapy of Chagas' disease.
score: 1.7100251, Antimicrobial agents and chemotherapy, 2005, Senkovich, Olga et. al.
A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease
score: 1.7099823, Bioorganic & Medicinal Chemistry, 2003, Toda, Narihiro et. al.
Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells
score: 1.7099471, Bioorganic & Medicinal Chemistry, 2012, Leal, Ana S.; Wang, Rui; Salvador, Jorge A.R.; Jing, Yongkui
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase
score: 1.7098307, Bioorganic & Medicinal Chemistry, 2012, Linsky, Thomas W.; Fast, Walter
Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives
score: 1.7097812, European Journal of Medicinal Chemistry, 2012, Wang, Peng et. al.
Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential
score: 1.7096306, Bioorganic & Medicinal Chemistry, 2006, Yasuhara, Akito et. al.
Aminothienopyridazine Inhibitors of Tau Aggregation: Evaluation of Structure-Activity Relationship Leads to Selection of Candidates with Desirable In Vivo Properties
score: 1.7096039, Bioorganic & Medicinal Chemistry, 2012, Ballatore, Carlo et. al.
Nonactin biosynthesis: Setting limits on what can be achieved with precursor-directed biosynthesis
score: 1.7094983, Bioorganic & Medicinal Chemistry Letters, 2009, Kusche, Brian R.; Phillips, Joshua B.; Priestley, Nigel D.
Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF.
score: 1.7091766, Antimicrobial agents and chemotherapy, 2006, Baum, Ellen Z et. al.
Synthesis, antimycobacterial and antitumor activities of new (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3 H)-yl)methyl N, N-disubstituted dithiocarbamate/ O-alkyldithiocarbonate derivatives
score: 1.7090845, Bioorganic & Medicinal Chemistry, 2006, Güzel, Özlen; Salman, Aydın
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship
score: 1.7090446, Bioorganic & Medicinal Chemistry, 2004, Murias, Marek et. al.
Synthesis and cytotoxicity of novel isomeric C-seco limonoids
score: 1.7089984, European Journal of Medicinal Chemistry, 2006, Genupur, Anitha et. al.
Structure–activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification
score: 1.7088875, Bioorganic & Medicinal Chemistry Letters, 2012, Sun, Xicheng et. al.
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity
score: 1.7084879, Bioorganic & Medicinal Chemistry, 2005, Bacherikov, Valeriy A. et. al.
Enantioselective synthesis of A 3′-dephenylcryptophycin synthon
score: 1.7083128, Bioorganic & Medicinal Chemistry Letters, 1998, Eggen, MariJean; Georg, Gunda I.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 1.708308, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 1.708308, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 1.708308, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Novel potent metallocenes against liver stage malaria.
score: 1.7083072, Antimicrobial agents and chemotherapy, 2012, Matos, Joana et. al.
Footprint-based identification of viral entry inhibitors targeting HIVgp41
score: 1.7079302, Bioorganic & Medicinal Chemistry Letters, 2012, Holden, Patrick M. et. al.
Potent and orally active ET A selective antagonists with 5,7-diarylcyclopenteno[1,2- b]pyridine-6-carboxylic acid structures
score: 1.7078744, Bioorganic & Medicinal Chemistry, 2004, Yoshizumi, Takashi et. al.
An Hsp90 modulator that exhibits a unique mechanistic profile
score: 1.7076713, Bioorganic & Medicinal Chemistry Letters, 2012, Ramsey, Deborah M. et. al.
An Hsp90 modulator that exhibits a unique mechanistic profile
score: 1.7076713, Bioorganic & Medicinal Chemistry Letters, 2012, Ramsey, Deborah M. et. al.
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family
score: 1.7074929, Bioorganic & Medicinal Chemistry Letters, 2012, Finlay, M. Raymond V.; Griffin, Roger J.
Synthesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives
score: 1.707435, Bioorganic & Medicinal Chemistry, 2006, Foroumadi, Alireza et. al.
Novel macrocyclic and acyclic cationic lipids for gene transfer: Synthesis and in vitro evaluation
score: 1.7073915, Bioorganic & Medicinal Chemistry Letters, 2012, Goldring, William P.D. et. al.
Novel macrocyclic and acyclic cationic lipids for gene transfer: Synthesis and in vitro evaluation
score: 1.7073915, Bioorganic & Medicinal Chemistry Letters, 2012, Goldring, William P.D. et. al.
Glycopeptide mimics of mammalian Man 9GlcNAc 2. Ligand binding to mannan-binding proteins (MBPs)
score: 1.7070498, Bioorganic & Medicinal Chemistry, 1996, Franzyk, Henrik et. al.
Is a Nitrogen Atom an Important Pharmacophoric Element in Sigma Ligand Binding?
score: 1.7070103, Bioorganic & Medicinal Chemistry, 2000, Ablordeppey, Seth Y; Fischer, James B; Glennon, Richard A
Synthesis, structure–activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives
score: 1.706944, European Journal of Medicinal Chemistry, 2012, Liu, Yan-Xin et. al.
Mechanism and structure–activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase
score: 1.7068512, Bioorganic & Medicinal Chemistry, 2005, Dixon, Mark J. et. al.
Discovery of ITX 4520: A highly potent orally bioavailable hepatitis C virus entry inhibitor
score: 1.7068139, Bioorganic & Medicinal Chemistry Letters, 2012, Mittapalli, Gopi Kumar et. al.
Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin.
score: 1.7067572, Antimicrobial agents and chemotherapy, 2012, Shahinas, Dea et. al.
Synthesis and binding mode of heterocyclic analogues of suramin inhibiting the human basic fibroblast growth factor
score: 1.7067456, Bioorganic & Medicinal Chemistry, 1998, Manetti, Fabrizio et. al.
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective Protein Tyrosine Phosphatase 1B inhibitors
score: 1.7067252, Bioorganic & Medicinal Chemistry Letters, 2012, Cheung, Adrian Wai-Hing et. al.
Synthesis and biological evaluation of novel N-acyl substituted quinolin-2(1H)-one derivatives as potential antimicrobial agents
score: 1.7067157, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Hong-Bin et. al.
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
score: 1.7066225, European Journal of Medicinal Chemistry, 2012, Bertinaria, Massimo et. al.
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
score: 1.7066225, European Journal of Medicinal Chemistry, 2012, Bertinaria, Massimo et. al.
8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A 2B
score: 1.7066101, European Journal of Medicinal Chemistry, 2004, Carotti, Angelo et. al.
Synthesis of new chemical entities from paracetamol and NSAIDs with improved pharmacodynamic profile
score: 1.7065724, Bioorganic & Medicinal Chemistry, 2006, Yadav, Mange Ram et. al.
Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies
score: 1.7063621, Bioorganic & Medicinal Chemistry Letters, 2010, Roucairol, Camille et. al.
Stable extended human immunodeficiency virus type 1 gp41 coiled coil as an effective target in an assay for high-affinity fusion inhibitors.
score: 1.7063512, Antimicrobial agents and chemotherapy, 2009, Cai, Lifeng; Balogh, Edina; Gochin, Miriam
Activity predictions for efavirenz analogues with the K103N mutant of HIV reverse transcriptase
score: 1.7063447, Bioorganic & Medicinal Chemistry Letters, 2003, Udier-Blagović, Marina et. al.
Comparative molecular field analysis of selective A 3 adenosine receptor agonists
score: 1.7063018, Bioorganic & Medicinal Chemistry, 1995, Siddiqi, Suhaib M. et. al.
Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state
score: 1.706284, Bioorganic & Medicinal Chemistry, 2012, Wielgus-Kutrowska, Beata et. al.
Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state
score: 1.706284, Bioorganic & Medicinal Chemistry, 2012, Wielgus-Kutrowska, Beata et. al.
Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state
score: 1.706284, Bioorganic & Medicinal Chemistry, 2012, Wielgus-Kutrowska, Beata et. al.
Novel and expanded jadomycins incorporating non-proteogenic amino acids
score: 1.7061556, Bioorganic & Medicinal Chemistry Letters, 2005, Jakeman, David L.; Graham, Cathy L.; Reid, Taryn R.
Nitrofurylsemicarbazone Rhenium and Ruthenium Complexes as Anti-trypanosomal Agents
score: 1.7059005, European Journal of Medicinal Chemistry, 2006, Otero, Lucía et. al.
Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C
score: 1.7057362, Bioorganic & Medicinal Chemistry, 2012, Zervosen, Astrid et. al.
Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C
score: 1.7057362, Bioorganic & Medicinal Chemistry, 2012, Zervosen, Astrid et. al.
3D-QSAR studies on tripeptide aldehyde inhibitors of proteasome using CoMFA and CoMSIA methods
score: 1.7054744, Bioorganic & Medicinal Chemistry, 2006, Zhu, Yong-Qiang et. al.
Design, Synthesis, and Biological Evaluation of Chalcone Oxime Derivatives as Potential Immunosuppressive Agents
score: 1.705248, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Yin et. al.
Novel 5-substituted, 2,4-diaminofuro[2,3- d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity
score: 1.7050775, Bioorganic & Medicinal Chemistry, 2005, Gangjee, Aleem et. al.
Building a successful structural motif into sialylmimetics—cyclohexenephosphonate monoesters as pseudo-sialosides with promising inhibitory properties
score: 1.7050748, Bioorganic & Medicinal Chemistry, 2006, Streicher, Hansjörg; Busse, Heike
Synthesis and properties of cationic 2′-O-[N-(4-aminobutyl)carbamoyl] modified oligonucleotides
score: 1.7046565, Bioorganic & Medicinal Chemistry Letters, 2012, Seio, Kohji et. al.
An improved synthesis of arsenic–biotin conjugates
score: 1.7046016, Bioorganic & Medicinal Chemistry, 2008, Heredia-Moya, Jorge; Kirk, Kenneth L.
Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives
score: 1.7042641, Bioorganic & Medicinal Chemistry, 2003, Cuellar, Mauricio A. et. al.
Synthesis and biological evaluation of orally active matrix metalloproteinase inhibitors
score: 1.7041701, Bioorganic & Medicinal Chemistry, 1997, Hirayama, Ryoichi et. al.
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720
score: 1.7041246, Bioorganic & Medicinal Chemistry, 2004, Hale, Jeffrey J. et. al.
Heteropoly acids as solid green Brønsted acids for a one-pot synthesis of β-acetamido ketones by Dakin–West reaction
score: 1.7041097, Bioorganic & Medicinal Chemistry Letters, 2006, Rafiee, Ezzat; Tork, Fariba; Joshaghani, M.
Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines
score: 1.7041095, European Journal of Medicinal Chemistry, 2005, Katiyar, D. et. al.
Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
score: 1.7037987, Bioorganic & Medicinal Chemistry Letters, 2012, Khan, Mohammad Faheem et. al.
Studies on the chemistry of thienoanellated O, N- and S, N-containing heterocycles. Part 30: Synthesis and pharmacological properties of thieno[2,3- b][1,4]thiazines with potential vasopressin receptor antagonistic activity
score: 1.7036258, Bioorganic & Medicinal Chemistry, 2006, Galanski, Maria E. et. al.
Molecular modeling and 3D-QSAR studies of indolomorphinan derivatives as kappa opioid antagonists
score: 1.7034625, Bioorganic & Medicinal Chemistry, 2006, Li, Wei; Tang, Yun; Zheng, You-Li; Qiu, Zhui-Bai
Anti-viral activity of (-)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.7031281, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy
score: 1.7029246, Bioorganic & Medicinal Chemistry Letters, 2012, Adams, Mark E. et. al.
Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata
score: 1.7028752, Bioorganic & Medicinal Chemistry, 2006, Cheenpracha, Sarot et. al.
Design, synthesis and biological evaluation of novel riccardiphenol analogs
score: 1.7028196, Bioorganic & Medicinal Chemistry, 2005, Kumar, Srinivas K. et. al.
Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor
score: 1.7027768, Bioorganic & Medicinal Chemistry Letters, 2013, Giordanetto, Fabrizio et. al.
Synthesis, characterization and biological evaluation of novel 6-ferrocenyl-4-aryl-2-substituted pyrimidine derivatives
score: 1.7027217, European Journal of Medicinal Chemistry, 2010, Parveen, Humaira et. al.
Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro
score: 1.7025678, Bioorganic & Medicinal Chemistry, 1997, Posner, Gary H. et. al.
Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.
score: 1.7023794, Antimicrobial agents and chemotherapy, 2011, Carroll, Steven S et. al.
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1
score: 1.7023362, Bioorganic & Medicinal Chemistry Letters, 2012, Manjulatha, Khanapur et. al.
Synthesis of cembranoid analogues and evaluation of their potential as quorum sensing inhibitors
score: 1.7019389, Bioorganic & Medicinal Chemistry, 2013, Tello, Edisson; Castellanos, Leonardo; Duque, Carmenza
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors
score: 1.7019297, Bioorganic & Medicinal Chemistry, 2005, Rawal, Ravindra K. et. al.
Synthesis and glycosidase inhibitory activity of some N-substituted 5a-carba-β-fuco- and β-galactopyranosylamines, and selected derivatives
score: 1.7017982, Bioorganic & Medicinal Chemistry, 2004, Ogawa, Seiichiro et. al.
Purpuroines A–J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases
score: 1.701699, Bioorganic & Medicinal Chemistry, 2012, Shen, Shi; Liu, Dong; Wei, Chen; Proksch, Peter; Lin, Wenhan
Purpuroines A–J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases
score: 1.701699, Bioorganic & Medicinal Chemistry, 2012, Shen, Shi; Liu, Dong; Wei, Chen; Proksch, Peter; Lin, Wenhan
Purpuroines A–J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases
score: 1.701699, Bioorganic & Medicinal Chemistry, 2012, Shen, Shi; Liu, Dong; Wei, Chen; Proksch, Peter; Lin, Wenhan
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach
score: 1.7016054, European Journal of Medicinal Chemistry, 2013, Zhang, Zhichao et. al.
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach
score: 1.7016054, European Journal of Medicinal Chemistry, 2013, Zhang, Zhichao et. al.
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol
score: 1.7014999, Bioorganic & Medicinal Chemistry, 2012, Cho, Suengmok et. al.
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol
score: 1.7014999, Bioorganic & Medicinal Chemistry, 2012, Cho, Suengmok et. al.
Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux
score: 1.7012783, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Melvin J.; Zheng, Wanjun; Tendyke, Karen
Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux
score: 1.7012783, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Melvin J.; Zheng, Wanjun; Tendyke, Karen
Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux
score: 1.7012783, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Melvin J.; Zheng, Wanjun; Tendyke, Karen
Appraisal of GABA and PABA as linker: Design and synthesis of novel benzamide based histone deacetylase inhibitors
score: 1.7012515, European Journal of Medicinal Chemistry, 2012, Rajak, Harish et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.701078, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.701078, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.701078, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.7009948, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
Camptothecin: current perspectives
score: 1.7008673, Bioorganic & Medicinal Chemistry, 2004, Thomas, Craig J.; Rahier, Nicolas J.; Hecht, Sidney M.
Chemoenzymatic synthesis and biological evaluation of C-3 carbamate analogues of 1α,25-dihydroxyvitamin D 3
score: 1.700608, Bioorganic & Medicinal Chemistry, 2004, Gotor-Fernández, Vicente et. al.
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors
score: 1.7002373, Bioorganic & Medicinal Chemistry Letters, 2013, Ye, Xiaocong M. et. al.
Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole
score: 1.7002352, Bioorganic & Medicinal Chemistry Letters, 2010, Todoroki, Yasushi et. al.
Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
score: 1.7002069, European Journal of Medicinal Chemistry, 2012, Sumangala, V. et. al.
Novel non-steroidal/non-anilide type androgen antagonists: discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands
score: 1.700157, Bioorganic & Medicinal Chemistry, 2005, Wakabayashi, Ken-ichi et. al.
2-Alkynyl-8-aryladenines possessing an amide moiety: their synthesis and structure–activity relationships of effects on hepatic glucose production induced via agonism of the A 2B adenosine receptor
score: 1.6996252, Bioorganic & Medicinal Chemistry, 2001, Harada, Hitoshi et. al.
Synthesis and conformational analysis of peptide inhibitors of farnesyltransferase
score: 1.6995529, Bioorganic & Medicinal Chemistry, 1997, Byk, Gerardo et. al.
Synthesis, DNA binding and cleavage activity of macrocyclic polyamines bearing mono- or bis-acridine moieties
score: 1.6995109, European Journal of Medicinal Chemistry, 2010, Liu, Qiang et. al.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
score: 1.6994593, Bioorganic & Medicinal Chemistry, 2012, Nishida, Haruyuki et. al.
A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure–activity relationships (2)
score: 1.6994421, Bioorganic & Medicinal Chemistry, 2006, Nomura, Takashi et. al.
Synthesis of a novel prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2- trans-propenoic acid for colon delivery
score: 1.6993634, Bioorganic & Medicinal Chemistry Letters, 2005, Curini, Massimo; Epifano, Francesco; Genovese, Salvatore
Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties
score: 1.6992798, Bioorganic & Medicinal Chemistry Letters, 2012, Chang, Dong-Jo et. al.
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.
score: 1.6991021, Antimicrobial agents and chemotherapy, 1999, Patick, A K et. al.
Synthesis, and In vitro and In vivo muscarinic pharmacological properties of a series of 1,6-Dihydro-5-(4 H)-pyrimidinone oximes
score: 1.6990796, Bioorganic & Medicinal Chemistry, 1998, Plate, Ralf et. al.
Synthesis, structure−activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives
score: 1.6989321, European Journal of Medicinal Chemistry, 2012, Liu, Yan−Xin et. al.
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
score: 1.6988956, Bioorganic & Medicinal Chemistry Letters, 2012, Foot, Jonathan S. et. al.
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
score: 1.6988956, Bioorganic & Medicinal Chemistry Letters, 2012, Foot, Jonathan S. et. al.
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
score: 1.6988956, Bioorganic & Medicinal Chemistry Letters, 2012, Foot, Jonathan S. et. al.
Conformationally Restricted Hybrid Analogues of the Hormone 1α,25-Dihydroxyvitamin D 3: Design, Synthesis, and Biological Evaluation
score: 1.6985604, Bioorganic & Medicinal Chemistry, 2001, White, M.Christina et. al.
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
score: 1.6985074, Antimicrobial agents and chemotherapy, 2008, Cihlar, Tomas et. al.
Synthesis and structure–activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents
score: 1.6984587, Bioorganic & Medicinal Chemistry, 2005, Albrecht, Uwe et. al.
Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activity
score: 1.698243, Bioorganic & Medicinal Chemistry Letters, 2012, Min, Byung Sun et. al.
On the use of volume maps in the conformational analysis of vitamin D analogs
score: 1.6981749, Bioorganic & Medicinal Chemistry Letters, 1998, Van Haver, D.; De Clercq, P.J.
3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents
score: 1.6980607, Bioorganic & Medicinal Chemistry, 2002, Hellberg, Mark R. et. al.
Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: New selective ligands for the cannabinoid CB 2 receptor
score: 1.69775, Bioorganic & Medicinal Chemistry, 2006, Marriott, Karla-Sue C. et. al.
Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H 3-antagonists
score: 1.6977483, Bioorganic & Medicinal Chemistry, 2004, Mor, Marco et. al.
A novel and facile preparation of bremazocine enantiomers through optically pure N-norbremazocines
score: 1.6976935, Bioorganic & Medicinal Chemistry, 2004, Greiner, Elisabeth et. al.
Competitive antagonism of insect GABA receptors by iminopyridazine derivatives of GABA
score: 1.6975585, Bioorganic & Medicinal Chemistry, 2012, Rahman, Mohammad Mostafizur et. al.
Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
score: 1.6973265, Antimicrobial agents and chemotherapy, 2012, Zhu, Xiaohua et. al.
Cluster analysis and two-dimensional quantitative structure–activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors
score: 1.6969698, Bioorganic & Medicinal Chemistry Letters, 2006, Kadam, Rameshwar U.; Roy, Nilanjan
Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.
score: 1.6969419, Antimicrobial agents and chemotherapy, 1998, Turpin, J A et. al.
An improved synthesis of 1,2,4-oxadiazoles on solid support
score: 1.6969393, Bioorganic & Medicinal Chemistry Letters, 2001, Rice, Kenneth D.; Nuss, John M.
Novel postentry inhibitor of human immunodeficiency virus type 1 replication screened by yeast membrane-associated two-hybrid system.
score: 1.6967083, Antimicrobial agents and chemotherapy, 2011, Urano, Emiko et. al.
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s Disease
score: 1.6965565, Bioorganic & Medicinal Chemistry Letters, 2012, Al-Baghdadi, Osamah et. al.
Synthesis of novel long wavelength cationic chlorins via stereoselective aldol-like condensation
score: 1.6964322, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jia Zhu et. al.
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors
score: 1.6963986, European Journal of Medicinal Chemistry, 2012, Iranshahi, Mehrdad et. al.
Practical, asymmetric synthesis of 16-hydroxyeicosa-5( Z),8( Z), 11( Z),14( Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity
score: 1.6963803, Bioorganic & Medicinal Chemistry Letters, 2003, Reddy, Y.Krishna et. al.
Search for α-glucosidase inhibitors: New N-substituted valienamine and conduramine F-1 derivatives
score: 1.6963391, Bioorganic & Medicinal Chemistry, 2006, Łysek, Robert et. al.
Ester derivatives of annulated tetrahydroazocines: A new class of selective acetylcholinesterase inhibitors
score: 1.6963012, Bioorganic & Medicinal Chemistry, 2006, Carotti, Andrea et. al.
Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation
score: 1.6962361, Bioorganic & Medicinal Chemistry, 2006, Ganesh, Thota et. al.
Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolyl N-Acylhydrazone Derivatives
score: 1.6960481, Bioorganic & Medicinal Chemistry, 2000, Figueiredo, Juliana M et. al.
Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines
score: 1.69592, Bioorganic & Medicinal Chemistry Letters, 2013, Vandekerckhove, Stéphanie et. al.
ortho-Carbaborane Derivatives of Indomethacin as Cyclooxygenase (COX)-2 Selective Inhibitors
score: 1.6958775, Bioorganic & Medicinal Chemistry, 2012, Scholz, Matthias et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials
score: 1.695713, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines
score: 1.6956866, Bioorganic & Medicinal Chemistry, 2006, Mahaney, Paige E. et. al.
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties
score: 1.6954121, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Dayong et. al.
Potent antibacterial lysine–peptoid hybrids identified from a positional scanning combinatorial library
score: 1.6953497, Bioorganic & Medicinal Chemistry, 2006, Ryge, Trine S.; Hansen, Paul R.
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
score: 1.6953171, European Journal of Medicinal Chemistry, 2012, Marhadour, Sophie et. al.
Synthesis and SAR exploration of dinapsoline analogues
score: 1.6950921, Bioorganic & Medicinal Chemistry, 2004, Sit, Sing-Yuen et. al.
Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid.
score: 1.6949436, Antimicrobial agents and chemotherapy, 1999, Woo, A J; Strohl, W R; Priestley, N D
Synthesis and Structure–Activity Relationship of Diarylamide Derivatives as Selective Inhibitors of the Proliferation of Human Endothelial Cells
score: 1.6949421, Bioorganic & Medicinal Chemistry, 2002, Ogita, Haruhisa et. al.
Phthalazine PDE IV inhibitors: Conformational study of some 6-methoxy-1,4-disubstituted derivatives
score: 1.6948004, Bioorganic & Medicinal Chemistry, 2005, Haack, Thomas et. al.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor
score: 1.6944159, Bioorganic & Medicinal Chemistry Letters, 2012, Maloney, Patrick R. et. al.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor
score: 1.6944159, Bioorganic & Medicinal Chemistry Letters, 2012, Maloney, Patrick R. et. al.
The flexibility of the Le aLe x Tumor Associated Antigen central fragment studied by systematic and stochastic searches as well as dynamic simulations
score: 1.6941882, Bioorganic & Medicinal Chemistry, 2009, Jackson, Trudy A. et. al.
Unprecedented spirocyclization of 3-methyleneindoline-2-thiones during hydrolysis of the phytoalexin cyclobrassinin
score: 1.694163, Bioorganic & Medicinal Chemistry Letters, 2013, Pedras, M. Soledade C. et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.6940573, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups
score: 1.6939509, Bioorganic & Medicinal Chemistry, 2012, Tu, Zhude et. al.
Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn 2+ in aqueous solution
score: 1.6938065, Bioorganic & Medicinal Chemistry Letters, 2007, Joshi, Bishnu Prasad et. al.
Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
score: 1.6933809, Bioorganic & Medicinal Chemistry, 2012, Mokale, Santosh N.; Lokwani, Deepak; Shinde, Devanand B.
Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
score: 1.6933809, Bioorganic & Medicinal Chemistry, 2012, Mokale, Santosh N.; Lokwani, Deepak; Shinde, Devanand B.
Discovery and modification of Sulfur-containing Heterocyclic Pyrazoline Derivatives as Potential novel class of β-Ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.6932814, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yu-Shun et. al.
Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
score: 1.6932718, European Journal of Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
score: 1.6932718, European Journal of Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
score: 1.6932718, European Journal of Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Structure–activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors
score: 1.6931903, Bioorganic & Medicinal Chemistry, 2005, Wan, Sheng Biao et. al.
Effect of 4-substitution on psychotomimetic activity of 2,5-dimethoxy amphetamines as studied by means of different substituent parameter scales
score: 1.6931877, Bioorganic & Medicinal Chemistry Letters, 2006, Neuvonen, Kari; Neuvonen, Helmi; Fülöp, Ferenc
Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine
score: 1.6930883, Bioorganic & Medicinal Chemistry Letters, 2012, Clouser, Christine L. et. al.
Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine
score: 1.6930883, Bioorganic & Medicinal Chemistry Letters, 2012, Clouser, Christine L. et. al.
Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents
score: 1.6930279, Bioorganic & Medicinal Chemistry, 2006, Balbi, Alessandro et. al.
In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.
score: 1.6929564, Antimicrobial agents and chemotherapy, 2004, Urbina, Julio A et. al.
Anti-viral activity of (−)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.6928771, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Anti-viral activity of (−)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.6928771, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Anti-viral activity of (−)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.6928771, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives
score: 1.6928077, Bioorganic & Medicinal Chemistry, 2005, Bacherikov, Valeriy A. et. al.
QSAR of HIV-1 integrase inhibitors by genetic function approximation method
score: 1.6927517, Bioorganic & Medicinal Chemistry, 2002, Makhija, Mahindra T.; Kulkarni, Vithal M.
A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs
score: 1.6926341, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang
Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studies
score: 1.6926133, Bioorganic & Medicinal Chemistry, 2005, Lambert, Joshua D. et. al.
N-(5-substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase
score: 1.6923177, Bioorganic & Medicinal Chemistry, 1997, Beers, Scott A. et. al.
Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles
score: 1.6919601, Bioorganic & Medicinal Chemistry, 2005, Göker, Hakan; Boykin, David W.; Yıldız, Sulhiye
Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
score: 1.6918063, Bioorganic & Medicinal Chemistry Letters, 2012, Ágai-Csongor, Éva et. al.
Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
score: 1.6918063, Bioorganic & Medicinal Chemistry Letters, 2012, Ágai-Csongor, Éva et. al.
Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
score: 1.6918063, Bioorganic & Medicinal Chemistry Letters, 2012, Ágai-Csongor, Éva et. al.
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents
score: 1.6918056, European Journal of Medicinal Chemistry, 2012, Pierce, Larry T. et. al.
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents
score: 1.6918056, European Journal of Medicinal Chemistry, 2012, Pierce, Larry T. et. al.
Synthesis and antibacterial activity of some new 1-heteroaryl-5-amino-3 H/methyl-4-phenylpyrazoles
score: 1.6915466, Bioorganic & Medicinal Chemistry, 2006, Aggarwal, Ranjana et. al.
A graftable LDV peptidomimetic: Design, synthesis and application to a blood filtration membrane
score: 1.6914979, Bioorganic & Medicinal Chemistry Letters, 2008, Momtaz, Maryam et. al.
Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives
score: 1.6909442, European Journal of Medicinal Chemistry, 2012, Raimondi, Maria Valeria et. al.
Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives
score: 1.6909442, European Journal of Medicinal Chemistry, 2012, Raimondi, Maria Valeria et. al.
Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition
score: 1.6909413, Bioorganic & Medicinal Chemistry Letters, 2009, Ai, Chunzhi et. al.
Action mechanisms and structure–activity relationships of PI3Kγ inhibitors on the enzyme: a molecular modeling study
score: 1.6908921, European Journal of Medicinal Chemistry, 2006, Kuang, R.-R.; Qian, F.; Li, Z.; Wei, D.-Z.; Tang, Y.
Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents
score: 1.6907758, European Journal of Medicinal Chemistry, 2004, Mayence, Annie et. al.
In vitro antimycobacterial activities of 2'-monosubstituted isonicotinohydrazides and their cyanoborane adducts.
score: 1.6907652, Antimicrobial agents and chemotherapy, 2002, Maccari, Rosanna et. al.
Arylsulfonyl acridinyl derivatives acting on Plasmodium falciparum
score: 1.6907528, European Journal of Medicinal Chemistry, 2004, Santelli-Rouvier, Christiane et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl Esters, a Novel Compound Class with Potent Chemoreversal Activity
score: 1.6906068, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
score: 1.6905414, Bioorganic & Medicinal Chemistry, 2012, Nishida, Haruyuki et. al.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
score: 1.6905414, Bioorganic & Medicinal Chemistry, 2012, Nishida, Haruyuki et. al.
Binding affinity prediction of non-peptide inhibitors of HIV-1 protease using COMBINE model introduced from peptide inhibitors
score: 1.6904883, Bioorganic & Medicinal Chemistry Letters, 2006, Nakamura, Shinya; Nakanishi, Isao; Kitaura, Kazuo
Selenium-containing naphthalimides as anticancer agents: Design, synthesis and bioactivity
score: 1.6900569, Bioorganic & Medicinal Chemistry, 2012, Zhao, Liwei et. al.
Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
score: 1.6896645, Bioorganic & Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
score: 1.6896645, Bioorganic & Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
score: 1.689