Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents
score: 3.6628656, Bioorganic & Medicinal Chemistry Letters, 2012, Zheng, Chang-Ji et. al.
Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents
score: 3.6628656, Bioorganic & Medicinal Chemistry Letters, 2012, Zheng, Chang-Ji et. al.
Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents
score: 3.4967412, Bioorganic & Medicinal Chemistry Letters, 2012, Zheng, Chang-Ji et. al.
Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer
score: 3.4710488, Bioorganic & Medicinal Chemistry, 2006, Narayanasamy, Sureshbabu et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 3.4559426, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
score: 3.3117583, Bioorganic & Medicinal Chemistry, 2012, El-Sayed, Magda A.-A. et. al.
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
score: 3.3117583, Bioorganic & Medicinal Chemistry, 2012, El-Sayed, Magda A.-A. et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 3.2832079, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
Synthesis of (bis)Sulfonic acid, (bis)Benzamides as follicle-Stimulating hormone (FSH) antagonists
score: 3.2670747, Bioorganic & Medicinal Chemistry, 2002, Wrobel, Jay et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.2299842, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring
score: 3.2054235, European Journal of Medicinal Chemistry, 2003, Balsamo, Aldo et. al.
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors
score: 3.20411, Bioorganic & Medicinal Chemistry Letters, 2012, Ghosh, Arun K. et. al.
Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method
score: 3.2009278, European Journal of Medicinal Chemistry, 2006, Michaux, Catherine et. al.
Structure-activity relationships of cyclic enediynes related to dynemicin A—I. Synthesis and antitumor activity of 9-acetoxy enediynes equipped with aryl carbamate moieties
score: 3.1826276, Bioorganic & Medicinal Chemistry, 1997, Unno, Ryoichi et. al.
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
score: 3.1756367, Bioorganic & Medicinal Chemistry, 2012, El-Sayed, Magda A.-A. et. al.
Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template
score: 3.1584757, Bioorganic & Medicinal Chemistry, 2003, Hirayama, Fukushi et. al.
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors
score: 3.1545585, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents
score: 3.1541944, Bioorganic & Medicinal Chemistry Letters, 2013, Abuhaie, Cristina-Maria et. al.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 3.1488835, Bioorganic & Medicinal Chemistry Letters, 2012, Arasappan, Ashok et. al.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 3.1488835, Bioorganic & Medicinal Chemistry Letters, 2012, Arasappan, Ashok et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.1475443, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.1475443, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
score: 3.1475443, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Seung-Chul et. al.
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors
score: 3.145511, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors
score: 3.145511, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold
score: 3.1385797, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold
score: 3.1385797, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold
score: 3.1385797, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors
score: 3.128727, Bioorganic & Medicinal Chemistry, 2006, Anana, Raymond et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.1221269, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.1221269, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.1221269, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: New isoform-I selective nanomolar inhibitors
score: 3.1039262, Bioorganic & Medicinal Chemistry Letters, 2012, Sechi, Mario et. al.
Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)
score: 3.0748009, Bioorganic & Medicinal Chemistry, 2006, Chen, Qiao-Hong; Praveen Rao, P.N.; Knaus, Edward E.
Design, Synthesis and Structure-Activity-Relationship of 1,5-Tetrahydronaphthyridines as CETP Inhibitors
score: 3.0737728, Bioorganic & Medicinal Chemistry Letters, 2012, Fernandez, Maria-Carmen et. al.
Development of a new class of aromatase inhibitors: Design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives
score: 3.0736968, Bioorganic & Medicinal Chemistry, 2012, Bonfield, Kevin et. al.
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity
score: 3.0657998, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, John G. et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 3.0634226, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 3.0634226, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs
score: 3.0508715, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs
score: 3.0508715, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs
score: 3.0508715, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.
score: 3.0475337, Antimicrobial agents and chemotherapy, 2004, Chen, D et. al.
Lead Optimization of Purine Based Orally Bioavailable Mps1 (TTK) inhibitors
score: 3.0307992, Bioorganic & Medicinal Chemistry Letters, 2012, Vijay Kumar, D. et. al.
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents
score: 3.0207422, Bioorganic & Medicinal Chemistry, 2012, Özadalı, Keriman et. al.
3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases
score: 3.0042502, Bioorganic & Medicinal Chemistry, 2005, Thaimattam, Ram et. al.
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists
score: 3.00308, European Journal of Medicinal Chemistry, 2012, Zajdel, Paweł et. al.
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists
score: 3.00308, European Journal of Medicinal Chemistry, 2012, Zajdel, Paweł et. al.
Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II
score: 2.9877639, Bioorganic & Medicinal Chemistry, 2005, Muthas, Daniel et. al.
Discovery and optimization of novel purines as potent and selective CB2 agonists
score: 2.9673067, Bioorganic & Medicinal Chemistry Letters, 2012, Hollinshead, Sean P. et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 2.9483732, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Discovery and optimization of novel purines as potent and selective CB2 agonists
score: 2.9479996, Bioorganic & Medicinal Chemistry Letters, 2012, Hollinshead, Sean P. et. al.
Novel selective and potent 5-HT reuptake inhibitors with 5-HT 1D antagonist activity: chemistry and pharmacological evaluation of a series of thienopyran derivatives
score: 2.9476218, Bioorganic & Medicinal Chemistry, 2004, Torrado, Alicia et. al.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 2.9414623, Bioorganic & Medicinal Chemistry Letters, 2012, Arasappan, Ashok et. al.
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors
score: 2.9329371, Bioorganic & Medicinal Chemistry, 2006, Moretto, A.F. et. al.
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
score: 2.9321754, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Hee Jin et. al.
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
score: 2.9321754, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Hee Jin et. al.
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors
score: 2.930314, European Journal of Medicinal Chemistry, 2012, Puig-de-la-Bellacasa, Raimon et. al.
Inhibitors of Dengue Virus and West Nile Virus Proteases Based on the Aminobenzamide Scaffold
score: 2.9239603, Bioorganic & Medicinal Chemistry, 2012, Aravapalli, Sridhar et. al.
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
score: 2.9136166, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Hee Jin et. al.
Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.
score: 2.9117437, Antimicrobial agents and chemotherapy, 2012, Kusano-Kitazume, Akiko et. al.
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors
score: 2.9093767, Bioorganic & Medicinal Chemistry, 2012, Wu, Peng et. al.
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors
score: 2.9093767, Bioorganic & Medicinal Chemistry, 2012, Wu, Peng et. al.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors
score: 2.9060786, Bioorganic & Medicinal Chemistry Letters, 2012, Peterson, Emily A. et. al.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors
score: 2.8901428, Bioorganic & Medicinal Chemistry Letters, 2012, Peterson, Emily A. et. al.
Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptase.
score: 2.8852602, Antimicrobial agents and chemotherapy, 1998, Sudbeck, E A et. al.
SAR Analysis of a Series of Acylthiourea Derivatives Possessing Broad-Spectrum Antiviral Activity
score: 2.881292, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors
score: 2.8533727, Bioorganic & Medicinal Chemistry, 2012, Wu, Peng et. al.
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.8524686, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability
score: 2.8499891, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Junwon et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.8491109, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.8491109, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
The design, synthesis and biological evaluation of PIM kinase inhibitors
score: 2.8483512, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
score: 2.8330449, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
score: 2.8330449, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
score: 2.8330449, Bioorganic & Medicinal Chemistry Letters, 2012, Burgeson, James R. et. al.
Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.
score: 2.8312454, Antimicrobial agents and chemotherapy, 2011, Vilchèze, Catherine et. al.
Design, synthesis and structure–activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors
score: 2.8261477, Bioorganic & Medicinal Chemistry Letters, 2012, Fernandez, Maria-Carmen et. al.
Design, synthesis and structure–activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors
score: 2.8261477, Bioorganic & Medicinal Chemistry Letters, 2012, Fernandez, Maria-Carmen et. al.
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
score: 2.8245864, Bioorganic & Medicinal Chemistry, 2012, Hayakawa, Ichiro et. al.
Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B)
score: 2.8181008, Bioorganic & Medicinal Chemistry, 2002, Liljebris, Charlotta et. al.
Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors
score: 2.8098575, Bioorganic & Medicinal Chemistry, 1998, Scheidt, Karl A. et. al.
Benzo[1,2- c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds
score: 2.8089834, Bioorganic & Medicinal Chemistry, 2005, Aguirre, Gabriela et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part III: Synthesis of potent antagonists with α vβ 3/α IIbβ 3 dual activity and improved water solubility
score: 2.808041, Bioorganic & Medicinal Chemistry, 2006, Ishikawa, Minoru et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.8062758, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors
score: 2.80531, Bioorganic & Medicinal Chemistry, 2012, Harada, Koichiro et. al.
Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors
score: 2.80531, Bioorganic & Medicinal Chemistry, 2012, Harada, Koichiro et. al.
Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors
score: 2.80531, Bioorganic & Medicinal Chemistry, 2012, Harada, Koichiro et. al.
Hybrid furoxanylN-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates
score: 2.8003255, European Journal of Medicinal Chemistry, 2013, Hernández, Paola et. al.
Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates
score: 2.8003255, European Journal of Medicinal Chemistry, 2013, Hernández, Paola et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.7955247, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
Structure-based Bioisosterism Design, Synthesis and Biological Evaluation of Novel 1,2,4-Triazin-6-ylthioacetamides As Potent HIV-1 NNRTIs
score: 2.7953864, Bioorganic & Medicinal Chemistry Letters, 2012, Zhan, Peng et. al.
3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold
score: 2.7903948, Bioorganic & Medicinal Chemistry, 2006, Xie, Aihua; Sivaprakasam, Prasanna; Doerksen, Robert J.
Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.7841849, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.7841849, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
score: 2.7841849, Bioorganic & Medicinal Chemistry Letters, 2012, McIver, Edward G. et. al.
Dihydropyridine neuropeptide Y Y 1 receptor antagonists 2
score: 2.7816732, Bioorganic & Medicinal Chemistry, 2004, Poindexter, Graham S et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.7808622, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.7808622, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes
score: 2.7808622, Bioorganic & Medicinal Chemistry, 2012, Sandgren, Veronica et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
score: 2.7655694, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
score: 2.7655694, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
score: 2.7655694, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Structure-activity relationships of cyclic enediynes related to dynemicin A—II. Synthesis and antitumor activity of 9- and 12-substituted enediynes equipped with aryl carbamate moieties
score: 2.762678, Bioorganic & Medicinal Chemistry, 1997, Unno, Ryoichi et. al.
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure
score: 2.7609547, Bioorganic & Medicinal Chemistry, 2005, Yamazaki, Kazuo et. al.
Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines
score: 2.7572371, Bioorganic & Medicinal Chemistry, 2012, Dosa, Stefan et. al.
Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines
score: 2.7572371, Bioorganic & Medicinal Chemistry, 2012, Dosa, Stefan et. al.
Recent methodologies toward the synthesis of valdecoxib: A potential 3,4-diarylisoxazolyl COX-II inhibitor
score: 2.7560746, European Journal of Medicinal Chemistry, 2010, Dadiboyena, Sureshbabu; Nefzi, Adel
3D-QSAR CoMFA/CoMSIA studies on Urokinase plasminogen activator (uPA) inhibitors: a strategic design in novel anticancer agents
score: 2.7542768, Bioorganic & Medicinal Chemistry, 2004, Bhongade, B.A.; Gadad, A.K.
Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors
score: 2.7536366, Bioorganic & Medicinal Chemistry, 2004, Singh, Sunil K. et. al.
An efficient one–pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.7498645, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.7449431, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Pharmacophore modeling, virtual screening and 3D-QSAR studies of 5-tetrahydroquinolinylidine aminoguanidine derivatives as sodium hydrogen exchanger inhibitors
score: 2.7441149, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Hardik G.; Patel, Paresh K.
Pharmacophore modeling, virtual screening and 3D-QSAR studies of 5-tetrahydroquinolinylidine aminoguanidine derivatives as sodium hydrogen exchanger inhibitors
score: 2.7441149, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Hardik G.; Patel, Paresh K.
A new structural theme in C 2-symmetric HIV-1 protease inhibitors: ortho-Substituted P1/P1′ side chains
score: 2.7432909, Bioorganic & Medicinal Chemistry, 2006, Wannberg, Johan et. al.
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
score: 2.7411716, Bioorganic & Medicinal Chemistry, 2012, Di Francesco, M. Emilia et. al.
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
score: 2.7411716, Bioorganic & Medicinal Chemistry, 2012, Di Francesco, M. Emilia et. al.
N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion.
score: 2.7406879, Antimicrobial agents and chemotherapy, 2004, Jiang, Shibo et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.7391412, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.7391412, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.7391412, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-HSV agent
score: 2.7367062, Bioorganic & Medicinal Chemistry Letters, 2012, Karampuri, Srinivas et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.733363, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening
score: 2.732586, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Weijun; Chen, Gang; Zhu, Weiliang; Zuo, Zhili
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors
score: 2.7319894, European Journal of Medicinal Chemistry, 2012, Golub, Andriy G. et. al.
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors
score: 2.7319894, European Journal of Medicinal Chemistry, 2012, Golub, Andriy G. et. al.
Computational studies of COX-2 inhibitors: 3D-QSAR and docking
score: 2.7282588, Bioorganic & Medicinal Chemistry, 2004, Kim, Hye-Jung et. al.
Novel Morpholinone-Based d-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex
score: 2.727966, Bioorganic & Medicinal Chemistry, 2002, Dahlgren, Anders et. al.
Early phase drug discovery: Cheminformatics and computational techniques in identifying lead series
score: 2.7239078, Bioorganic & Medicinal Chemistry, 2012, Duffy, Bryan C. et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 2.7202735, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
score: 2.7202735, Bioorganic & Medicinal Chemistry, 2012, Chen, Xuwang et. al.
High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity
score: 2.7193504, Bioorganic & Medicinal Chemistry, 2006, Wheelock, Craig E. et. al.
C 17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1 H-imidazoles as novel C 17,20-lyase inhibitors
score: 2.7087168, Bioorganic & Medicinal Chemistry, 2004, Matsunaga, Nobuyuki et. al.
Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity
score: 2.706489, Bioorganic & Medicinal Chemistry, 2003, Sørensen, Morten Dahl et. al.
A Highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.7056516, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein
score: 2.7011222, Bioorganic & Medicinal Chemistry, 2012, Li, Huan-qiu; Yang, Jing; Ma, Shuhua; Qiao, Chunhua
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein
score: 2.7011222, Bioorganic & Medicinal Chemistry, 2012, Li, Huan-qiu; Yang, Jing; Ma, Shuhua; Qiao, Chunhua
Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study
score: 2.6999497, Bioorganic & Medicinal Chemistry, 2002, Cho, Won-Jea et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.6978002, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors
score: 2.6968903, Bioorganic & Medicinal Chemistry Letters, 2012, Bussenius, Joerg et. al.
Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase
score: 2.6933257, Bioorganic & Medicinal Chemistry, 2005, Khabnadideh, Soghra et. al.
Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: A novel class of cyclooxygenase-2 inhibitors
score: 2.6919139, Bioorganic & Medicinal Chemistry, 2005, Chen, Qiao-Hong; Praveen Rao, P.N.; Knaus, Edward E.
CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues
score: 2.6909021, Bioorganic & Medicinal Chemistry, 2006, Salama, Ismail et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.69024, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.69024, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists
score: 2.69024, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
score: 2.6881256, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Bin et. al.
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells
score: 2.6879668, Bioorganic & Medicinal Chemistry Letters, 2013, Medda, Federico et. al.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
score: 2.6858892, Bioorganic & Medicinal Chemistry Letters, 2012, Buchstaller, Hans-Peter et. al.
Design and synthesis of ( Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and ( Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity
score: 2.684667, Bioorganic & Medicinal Chemistry, 2005, Uddin, Md. Jashim; Rao, P.N. Praveen; Knaus, Edward E.
Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization
score: 2.6833612, European Journal of Medicinal Chemistry, 2012, Yang, Ling-Ling et. al.
Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization
score: 2.6833612, European Journal of Medicinal Chemistry, 2012, Yang, Ling-Ling et. al.
Synthesis and structure–activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold
score: 2.674852, Bioorganic & Medicinal Chemistry Letters, 2012, Wurz, Ryan P. et. al.
Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity
score: 2.6726163, European Journal of Medicinal Chemistry, 2012, Rasolofonjatovo, Evelia et. al.
Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity
score: 2.6726163, European Journal of Medicinal Chemistry, 2012, Rasolofonjatovo, Evelia et. al.
3D QSAR studies of AChE inhibitors based on molecular docking scores and CoMFA
score: 2.6719675, Bioorganic & Medicinal Chemistry Letters, 2006, Akula, Nagaraju et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.6716282, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.6716282, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems Part IV. 2-Alkyl substituents containing cationic heteroaromatics linked via a C–C bond
score: 2.6700975, Bioorganic & Medicinal Chemistry, 2001, Azami, Hidenori et. al.
Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3- O-(3-Aryl-2-propenyl)leucomycin analogues
score: 2.6672464, Bioorganic & Medicinal Chemistry, 2008, Furuuchi, Takeshi et. al.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.6617138, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.6617138, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.6617138, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase
score: 2.6519762, Bioorganic & Medicinal Chemistry, 2005, Jackson, Sharon A. et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.6508174, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
score: 2.6504389, European Journal of Medicinal Chemistry, 2012, Zhu, Wufu et. al.
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
score: 2.6504389, European Journal of Medicinal Chemistry, 2012, Zhu, Wufu et. al.
A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.6471356, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.6471356, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells
score: 2.6299956, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Breland et. al.
Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.6224146, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues
score: 2.6205934, European Journal of Medicinal Chemistry, 2012, Mahmoud, Amr H. et. al.
3D-QSAR, homology modeling, and molecular docking studies on spiropiperidines analogues as agonists of nociceptin/orphanin FQ receptor
score: 2.6173835, Bioorganic & Medicinal Chemistry Letters, 2010, Liu, Ming; He, Lin; Hu, Xiaopeng; Liu, Peiqing; Luo, Hai-Bin
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors
score: 2.61694, European Journal of Medicinal Chemistry, 2012, Golub, Andriy G. et. al.
Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR)
score: 2.6155676, Bioorganic & Medicinal Chemistry Letters, 2012, Zinglé, Catherine et. al.
Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR)
score: 2.6155676, Bioorganic & Medicinal Chemistry Letters, 2012, Zinglé, Catherine et. al.
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102
score: 2.6148777, Bioorganic & Medicinal Chemistry, 2012, Huynh, Tri H.V. et. al.
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102
score: 2.6148777, Bioorganic & Medicinal Chemistry, 2012, Huynh, Tri H.V. et. al.
Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors
score: 2.6147452, Bioorganic & Medicinal Chemistry, 2006, Li, Xingnan; Vince, Robert
Antitumor agents 294. Novel E-ring-modified camptothecin–4β-anilino-4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents
score: 2.6138171, Bioorganic & Medicinal Chemistry, 2012, Ye, Deyong et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.613779, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.613779, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.613779, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists
score: 2.6108193, Bioorganic & Medicinal Chemistry Letters, 2004, Newhouse, Bradley et. al.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
score: 2.6105959, Bioorganic & Medicinal Chemistry Letters, 2012, Aguilar, Nuria et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.6054665, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.6054665, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles
score: 2.6043932, Bioorganic & Medicinal Chemistry, 2004, Ranatunge, Ramani R. et. al.
Discovery of MEK/PI3K dual inhibitor via structure-based virtual screening
score: 2.6035831, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Hwangseo; Lee, Soyoung; Hong, Sungwoo
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells
score: 2.6009803, Bioorganic & Medicinal Chemistry Letters, 2012, Pierre, Fabrice et. al.
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells
score: 2.6009803, Bioorganic & Medicinal Chemistry Letters, 2012, Pierre, Fabrice et. al.
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach
score: 2.5986795, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach
score: 2.5986795, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach
score: 2.5986795, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
Design, synthesis, and biological activity of N 6-substituted-4′-thioadenosines at the human A 3 adenosine receptor
score: 2.5973048, Bioorganic & Medicinal Chemistry, 2006, Jeong, Lak Shin et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity
score: 2.5972125, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity
score: 2.5972125, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
Structure–activity studies of a series of dipyrazolo[3,4- b:3′,4′- d]pyridin-3-ones binding to the immune regulatory protein B7.1
score: 2.5934688, Bioorganic & Medicinal Chemistry, 2003, Green, Neal J. et. al.
Design, Synthesis and Pharmacological Characterization of Coumarin-Based Fluorescent Analogs of Excitatory Amino Acid Transporter Subtype 1 selective Inhibitors, UCPH-101 and UCPH-102
score: 2.5927752, Bioorganic & Medicinal Chemistry, 2012, Huynh, Tri H.V. et. al.
Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II
score: 2.5924991, Bioorganic & Medicinal Chemistry, 2003, Dahlgren, Anders et. al.
Design and synthesis of procollagen C-proteinase inhibitors
score: 2.5921306, Bioorganic & Medicinal Chemistry Letters, 2012, Turtle, Eric et. al.
Design and synthesis of procollagen C-proteinase inhibitors
score: 2.5921306, Bioorganic & Medicinal Chemistry Letters, 2012, Turtle, Eric et. al.
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy- d-xylulose 5-phosphate reductoisomerase
score: 2.5914473, Bioorganic & Medicinal Chemistry, 2006, Woo, Youn-Hi; Fernandes, Roberta P.M.; Proteau, Philip J.
Design and synthesis of Rho kinase inhibitors (I)
score: 2.5907077, Bioorganic & Medicinal Chemistry, 2004, Takami, Atsuya et. al.
Pyrazole[3,4-e][1,4]thiazepin-7-one Derivatives as a Novel Class of Farnesoid X Receptor (FXR) Agonists
score: 2.5903221, Bioorganic & Medicinal Chemistry, 2012, Marinozzi, Maura et. al.
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors
score: 2.5807084, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors
score: 2.5807084, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors
score: 2.5807084, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Virtual screening of combinatorial libraries across a gene family: in search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase.
score: 2.5780891, Antimicrobial agents and chemotherapy, 2001, Aronov, A M; Munagala, N R; Kuntz, I D; Wang, C C
Design, synthesis, and biological evaluation of ( E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases
score: 2.576323, Bioorganic & Medicinal Chemistry, 2006, Moreau, Anne et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.5746901, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: Improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy
score: 2.5745183, Bioorganic & Medicinal Chemistry, 2012, Kawakita, Youichi et. al.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families
score: 2.5737238, Bioorganic & Medicinal Chemistry Letters, 2012, Curtin, Michael L. et. al.
A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site
score: 2.5685361, Bioorganic & Medicinal Chemistry, 2004, Foloppe, Nicolas et. al.
Design, synthesis and biological activity of YM-60828 derivatives: potent and orally-Bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates
score: 2.5679825, Bioorganic & Medicinal Chemistry, 2002, Hirayama, Fukushi et. al.
Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3 H-diazirin-3-yl functional group for photo-affinity labeling
score: 2.5675692, Bioorganic & Medicinal Chemistry, 2009, Kumar, Nag S.; Young, Robert N.
Novel ligands for the human histamine H 1 receptor: Synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes
score: 2.5635206, Bioorganic & Medicinal Chemistry, 2006, Ghoneim, Ola M. et. al.
Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity
score: 2.5629201, European Journal of Medicinal Chemistry, 2012, Rasolofonjatovo, Evelia et. al.
Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: Hydroxybenzoyl-3,4-dihydroquinoxalin-2(1 H)-ones
score: 2.5611377, Bioorganic & Medicinal Chemistry, 2006, Mahaney, Paige E. et. al.
Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors
score: 2.5581487, Bioorganic & Medicinal Chemistry Letters, 2013, Kim, Junwon et. al.
Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
score: 2.5515433, Bioorganic & Medicinal Chemistry, 2006, Walker, Daniel P. et. al.
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques
score: 2.5490979, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yao et. al.
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques
score: 2.5490979, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yao et. al.
Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors
score: 2.5485989, Bioorganic & Medicinal Chemistry, 2012, Smith, Aaron L. et. al.
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2
score: 2.5478906, Bioorganic & Medicinal Chemistry Letters, 2012, Vaidya, Aditya Sudheer et. al.
Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH
score: 2.5475893, European Journal of Medicinal Chemistry, 2012, Larghi, Enrique L. et. al.
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3 H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family
score: 2.546707, Bioorganic & Medicinal Chemistry, 2005, Mai, Antonello et. al.
Early phase drug discovery: Cheminformatics and computational techniques in identifying lead series
score: 2.5464498, Bioorganic & Medicinal Chemistry, 2012, Duffy, Bryan C. et. al.
Early phase drug discovery: Cheminformatics and computational techniques in identifying lead series
score: 2.5464498, Bioorganic & Medicinal Chemistry, 2012, Duffy, Bryan C. et. al.
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
score: 2.5454233, Bioorganic & Medicinal Chemistry Letters, 2012, Dakin, Les A. et. al.
Development of ‘DFG-out’ inhibitors of gatekeeper mutant kinases
score: 2.5446835, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Hwan Geun et. al.
Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus
score: 2.5425614, Bioorganic & Medicinal Chemistry Letters, 2012, Lizarzaburu, Mike et. al.
Ligand-based designing, in silico screening, and biological evaluation of new potent fructose-1,6-bisphosphatase (FBPase) inhibitors
score: 2.5404106, European Journal of Medicinal Chemistry, 2012, Tayyem, Rabab F. et. al.
Ligand-based designing, in silico screening, and biological evaluation of new potent fructose-1,6-bisphosphatase (FBPase) inhibitors
score: 2.5404106, European Journal of Medicinal Chemistry, 2012, Tayyem, Rabab F. et. al.
New orally active PDE4 inhibitors with therapeutic potential
score: 2.5387424, Bioorganic & Medicinal Chemistry, 2004, Ochiai, Hiroshi et. al.
Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3- a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase
score: 2.5384746, Bioorganic & Medicinal Chemistry, 2006, Sun, Chuanwen; Zhang, Xiaodong; Huang, Hai; Zhou, Pei
Design, synthesis and bioactivities of novel diarylthiophenes: inhibitors of tumor necrosis factor-α (TNF-α) production
score: 2.5368103, Bioorganic & Medicinal Chemistry, 2002, Fujita, Masakazu; Hirayama, Tetsuya; Ikeda, Naoko
POMA analyses as new efficient bioinformatics’ platform to predict and optimize bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5360688, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
score: 2.5353895, European Journal of Medicinal Chemistry, 2012, Zhu, Wufu et. al.
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
score: 2.5349706, European Journal of Medicinal Chemistry, 2012, Xie, Hui et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
score: 2.5347927, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates
score: 2.5335449, Bioorganic & Medicinal Chemistry Letters, 2012, Sund, Christian et. al.
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates
score: 2.5335449, Bioorganic & Medicinal Chemistry Letters, 2012, Sund, Christian et. al.
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
score: 2.5276291, Bioorganic & Medicinal Chemistry, 2006, Collins, Ian et. al.
Discovery and optimization of a series of liver X receptor antagonists
score: 2.5273336, Bioorganic & Medicinal Chemistry Letters, 2012, Jiao, XianYun et. al.
Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2′ to P1/P1′
score: 2.5261389, Bioorganic & Medicinal Chemistry, 2005, Ax, Anna et. al.
Design, synthesis, and biological evaluation of 1,3-diarylprop-2-en-1-ones : A novel class of cyclooxygenase-2 inhibitors
score: 2.525668, Bioorganic & Medicinal Chemistry, 2006, Zarghi, Afshin et. al.
An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.524857, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.524857, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
An efficient one-pot synthesis, structure, antimicrobial and antioxidant investigations of some novel quinolyldibenzo[b,e][1,4]diazepinones
score: 2.524857, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
score: 2.5247342, Bioorganic & Medicinal Chemistry Letters, 2012, Dakin, Les A. et. al.
Solid-phase synthesis and bioevaluation of Lupeol-based libraries as antimalarial agents
score: 2.5227983, Bioorganic & Medicinal Chemistry Letters, 2002, Srinivasan, T et. al.
‘Sum of activities’ as dependent parameter: A new CoMFA-based approach for the design of pan PPAR agonists
score: 2.5219355, European Journal of Medicinal Chemistry, 2009, Sundriyal, Sandeep; Bharatam, Prasad V.
Analogues of FAUC 73 revealing new insights into the structural requirements of nonaromatic dopamine D3 receptor agonists
score: 2.5211103, Bioorganic & Medicinal Chemistry, 2004, Lenz, Carola et. al.
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase
score: 2.519841, Bioorganic & Medicinal Chemistry Letters, 2012, Ding, Min et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2
score: 2.5183328, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Semisynthetic neoclerodanes as kappa opioid receptor probes
score: 2.5179122, Bioorganic & Medicinal Chemistry, 2012, Lovell, Kimberly M. et. al.
Semisynthetic neoclerodanes as kappa opioid receptor probes
score: 2.5179122, Bioorganic & Medicinal Chemistry, 2012, Lovell, Kimberly M. et. al.
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)
score: 2.5175931, Bioorganic & Medicinal Chemistry, 2012, Banoglu, Erden et. al.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
score: 2.5164123, Bioorganic & Medicinal Chemistry, 2012, Tashiro, Takuya et. al.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
score: 2.5164123, Bioorganic & Medicinal Chemistry, 2012, Tashiro, Takuya et. al.
D-Ring Modified Estrone Derivatives as Novel Potent Inhibitors of Steroid Sulfatase
score: 2.5161801, Bioorganic & Medicinal Chemistry, 2003, Fischer, Delphine S et. al.
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.5140279, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.5140279, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5118032, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5118032, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
POMA analyses as new efficient bioinformatics’ platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
score: 2.5118032, Bioorganic & Medicinal Chemistry Letters, 2012, Ahsan, Mohamed Jawed et. al.
Pharmacophore Modeling, Virtual Screening and 3D-QSAR Studies of 5-tetrahydroquinolinylidine Aminoguanidine Derivatives as Sodium Hydrogen Exchanger Inhibitors
score: 2.5113585, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Hardik G.; Patel, Paresh K.
Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent
score: 2.5113136, Bioorganic & Medicinal Chemistry Letters, 2012, Thiyagarajan, Anandarajan et. al.
The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors
score: 2.5098839, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Moon H. et. al.
Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
score: 2.5096541, Bioorganic & Medicinal Chemistry, 2012, Romagnoli, Romeo et. al.
Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
score: 2.5096541, Bioorganic & Medicinal Chemistry, 2012, Romagnoli, Romeo et. al.
Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
score: 2.5096541, Bioorganic & Medicinal Chemistry, 2012, Romagnoli, Romeo et. al.
Synthesis and biological evaluation of 1,3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 inhibitors
score: 2.5085226, Bioorganic & Medicinal Chemistry, 2006, Zarghi, Afshin et. al.
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
score: 2.507184, Bioorganic & Medicinal Chemistry Letters, 2012, Bennett, Frank et. al.
Structure-Based Design of Rhodanine-based Acylsulfonamide Derivatives as Antagonists of the Anti-apoptotic Bcl-2 Protein
score: 2.5066672, Bioorganic & Medicinal Chemistry, 2012, Li, Huan-qiu; Yang, Jing; Ma, Shuhua; Qiao, Chunhua
2-Aminothiophenes as Building Blocks in Heterocyclic Synthesis: Synthesis and Antimicrobial Evaluation of a New Class of Pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and Pyridin-2-one Derivatives
score: 2.5060901, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
score: 2.5042357, Bioorganic & Medicinal Chemistry, 2012, Tashiro, Takuya et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part II
score: 2.503953, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Design and synthesis of procollagen C-proteinase inhibitors
score: 2.503642, Bioorganic & Medicinal Chemistry Letters, 2012, Turtle, Eric et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2
score: 2.5030143, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2
score: 2.5030143, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Myung-Ho et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.501603, European Journal of Medicinal Chemistry, 2012, Vega, María Celeste et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.501603, European Journal of Medicinal Chemistry, 2012, Vega, Maria Celeste et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.501603, European Journal of Medicinal Chemistry, 2012, Vega, María Celeste et. al.
A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus 1
score: 2.4982832, Bioorganic & Medicinal Chemistry, 2006, Arhin, Francis et. al.
The design, synthesis, and biological evaluation of PIM kinase inhibitors
score: 2.4977048, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
The design, synthesis, and biological evaluation of PIM kinase inhibitors
score: 2.4977048, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
The design, synthesis and biological evaluation of PIM kinase inhibitors
score: 2.4977048, Bioorganic & Medicinal Chemistry Letters, 2012, Tsuhako, Amy Lew et. al.
Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents
score: 2.4959195, Bioorganic & Medicinal Chemistry, 2006, Shinozuka, Tsuyoshi et. al.
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation
score: 2.4951368, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation
score: 2.4951368, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
score: 2.4951335, Bioorganic & Medicinal Chemistry, 2012, Guan, Peng et. al.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
score: 2.4930566, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D 3 analogues containing amide bond
score: 2.4913372, Bioorganic & Medicinal Chemistry Letters, 2002, Suhara, Yoshitomo et. al.
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors
score: 2.4897621, European Journal of Medicinal Chemistry, 2012, Jadhav, Ravindra D. et. al.
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors
score: 2.4897621, European Journal of Medicinal Chemistry, 2012, Jadhav, Ravindra D. et. al.
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors
score: 2.4897621, European Journal of Medicinal Chemistry, 2012, Jadhav, Ravindra D. et. al.
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.4890129, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
score: 2.4879479, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
score: 2.4855366, Bioorganic & Medicinal Chemistry Letters, 2012, Hsu, John T.-A. et. al.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
score: 2.4855366, Bioorganic & Medicinal Chemistry Letters, 2012, Hsu, John T.-A. et. al.
Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.
score: 2.485309, Antimicrobial agents and chemotherapy, 2011, Zoraghi, Roya et. al.
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
score: 2.4836411, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
score: 2.4836411, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
score: 2.4836411, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Structure–activity relationships of tyrosinase inhibitory combinatorial library of 2,5-disubstituted-1,3,4-oxadiazole analogues
score: 2.4822302, Bioorganic & Medicinal Chemistry, 2005, Khan, Mahmud Tareq Hassan et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.4821665, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Acyclic amides as estrogen receptor ligands: Synthesis, binding, activity and receptor interaction
score: 2.4820865, Bioorganic & Medicinal Chemistry, 2000, Stauffer, Shaun R et. al.
Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.4812446, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.4812446, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists
score: 2.4812446, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.4810918, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.4810918, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.4810918, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening
score: 2.478164, Bioorganic & Medicinal Chemistry Letters, 2012, Moser, Daniel et. al.
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening
score: 2.478164, Bioorganic & Medicinal Chemistry Letters, 2012, Moser, Daniel et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.4767401, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
Investigation on QSAR and binding mode of a new class of human rhinovirus-14 inhibitors by CoMFA and docking experiments
score: 2.4716941, Bioorganic & Medicinal Chemistry, 1996, Artico, Marino et. al.
Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation
score: 2.4699733, Bioorganic & Medicinal Chemistry Letters, 2012, Ellard, Katie et. al.
Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones
score: 2.4692332, Bioorganic & Medicinal Chemistry, 2003, Kongkathip, Ngampong et. al.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families
score: 2.467853, Bioorganic & Medicinal Chemistry Letters, 2012, Curtin, Michael L. et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as Potent Antagonists Targeting Exchange Proteins Directly Activated by cAMP
score: 2.4672748, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position
score: 2.4661794, Bioorganic & Medicinal Chemistry, 2006, Yoshida, Ken-ichi et. al.
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
score: 2.4628064, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Discovery and Optimization of Benzenesulfonanilide Derivatives as a Novel Class of 11β-HSD1 Inhibitors
score: 2.462096, Bioorganic & Medicinal Chemistry Letters, 2012, Rew, Yosup et. al.
Carbapenem-based prodrugs. Design, synthesis, and biological evaluation of carbapenems
score: 2.4616669, European Journal of Medicinal Chemistry, 2005, Hakimelahi, Gholam Hossein et. al.
Synthesis and antiparasitic activity of albendazole and mebendazole analogues
score: 2.4612353, Bioorganic & Medicinal Chemistry, 2003, Navarrete-Vázquez, Gabriel et. al.
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
score: 2.4607512, Bioorganic & Medicinal Chemistry, 2006, Ersmark, Karolina et. al.
QSAR study for a novel series of ortho monosubstituted phenoxy analogues of α 1-adrenoceptor antagonist WB4101
score: 2.4600816, Bioorganic & Medicinal Chemistry, 2005, Fumagalli, Laura et. al.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
score: 2.4582641, Bioorganic & Medicinal Chemistry Letters, 2012, Voss, Matthew E. et. al.
The discovery of glycine and related amino acid-based factor Xa inhibitors
score: 2.4575995, Bioorganic & Medicinal Chemistry, 2006, Kohrt, Jeffrey T. et. al.
Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents
score: 2.457089, Bioorganic & Medicinal Chemistry, 2005, Johns, Brian A. et. al.
Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV
score: 2.4567977, Bioorganic & Medicinal Chemistry, 2006, Flosi, William J. et. al.
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer
score: 2.4566787, Bioorganic & Medicinal Chemistry, 2012, Zhu, Gui-Dong et. al.
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
score: 2.4555964, Bioorganic & Medicinal Chemistry, 2004, Carrico, Dora et. al.
Synthesis and biological activity of novel thyroid hormone analogues: 5′-aryl substituted GC-1 derivatives
score: 2.4542586, Bioorganic & Medicinal Chemistry, 2002, Chiellini, Grazia et. al.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
score: 2.4537939, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
score: 2.4537939, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Comparative molecular field analysis and comparative molecular similarity indices analysis of boron-containing human thymidine kinase 1 substrates
score: 2.4534211, Bioorganic & Medicinal Chemistry, 2006, Bandyopadhyaya, Achintya K.; Tiwari, Rohit; Tjarks, Werner
A credit-card library approach for disrupting protein–protein interactions
score: 2.4530334, Bioorganic & Medicinal Chemistry, 2006, Xu, Yang et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.4516836, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Molecular modeling, design, synthesis, and biological evaluation of novel 3′,4′-dicamphanoyl-(+)- cis-khellactone (DCK) analogs as potent anti-HIV agents
score: 2.4510224, Bioorganic & Medicinal Chemistry, 2005, Xie, Lan et. al.
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents
score: 2.4489976, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xiao-Feng et. al.
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice
score: 2.4487344, Bioorganic & Medicinal Chemistry, 2012, dos Santos Filho, José Maurício et. al.
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice
score: 2.4487344, Bioorganic & Medicinal Chemistry, 2012, dos Santos Filho, José Maurício et. al.
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses
score: 2.4482163, Bioorganic & Medicinal Chemistry, 2005, Gudmundsson, Kristjan S. et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.4457771, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
score: 2.4457771, Bioorganic & Medicinal Chemistry Letters, 2012, Perez, Heidi L. et. al.
Optimization and Structure-Activity Relationships of a Series of Potent Inhibitors of Methicillin-Resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as Novel Antimicrobial Agents
score: 2.4456525, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
Inhibitors of acyl-CoA: cholesterol O-acyltransferase (ACAT). Part 1: Identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N′-arylureas
score: 2.4447364, Bioorganic & Medicinal Chemistry, 1998, Tanaka, Akira et. al.
The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors
score: 2.4444189, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Moon H. et. al.
Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy
score: 2.4443807, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Hyeseung et. al.
Novel synthetic analogs of the Pseudomonas autoinducer
score: 2.4428182, Bioorganic & Medicinal Chemistry Letters, 1999, Kline, T. et. al.
The synthesis and antibacterial activity of totarol derivatives. part 1: modifications of ring-C and pro-drugs
score: 2.4423164, Bioorganic & Medicinal Chemistry, 1999, Evans, Gary B et. al.
Design and synthesis of new (E)-Cinnamic N-Acylhydrazones as potent Antitrypanosomal agents
score: 2.4420112, European Journal of Medicinal Chemistry, 2012, Carvalho, Samir A. et. al.
Hit to Lead Optimization of a Novel Class of Squarate-containing Polo-like Kinases Inhibitors
score: 2.4405531, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2/4-quinolinecarbaldehyde derivatives
score: 2.4404866, Bioorganic & Medicinal Chemistry, 2006, Nayyar, Amit et. al.
Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes
score: 2.4382608, Bioorganic & Medicinal Chemistry Letters, 2012, DeNinno, Michael P. et. al.
Novel berberine triazoles: Synthesis, antimicrobial evaluation and competitive interactions with metal ions to Human Serum Albumin
score: 2.4377919, Bioorganic & Medicinal Chemistry Letters, 2013, Zhang, Shao-Lin et. al.
New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design
score: 2.4373161, Bioorganic & Medicinal Chemistry, 2006, Olsen, Lars et. al.
Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems. Part III:
score: 2.4361418, Bioorganic & Medicinal Chemistry, 1999, Azami, Hidenori et. al.
Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
score: 2.4348134, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
score: 2.4348134, Bioorganic & Medicinal Chemistry, 2012, Kumar, Nag S. et. al.
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.
score: 2.4328349, Antimicrobial agents and chemotherapy, 2006, Yang, Youjun et. al.
Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists
score: 2.4307131, Bioorganic & Medicinal Chemistry, 2012, Takeda, Kunitoshi et. al.
Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists
score: 2.4307131, Bioorganic & Medicinal Chemistry, 2012, Takeda, Kunitoshi et. al.
Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists
score: 2.4307131, Bioorganic & Medicinal Chemistry, 2012, Takeda, Kunitoshi et. al.
Combinatorial design of nonsymmetrical cyclic urea inhibitors of aspartic protease of HIV-1
score: 2.4292688, Bioorganic & Medicinal Chemistry, 2005, Frecer, Vladimír; Burello, Enrico; Miertus, Stanislav
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors
score: 2.4290229, Bioorganic & Medicinal Chemistry Letters, 2012, Girijavallabhan, Vinay M. et. al.
Synthesis and in vitro antitumor activity of novel scopoletin derivatives
score: 2.4281182, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Wukun et. al.
Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor
score: 2.4276094, Bioorganic & Medicinal Chemistry, 2005, Kuramochi, Takahiro et. al.
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents
score: 2.4268343, Bioorganic & Medicinal Chemistry, 2006, Monk, Keith A. et. al.
A road less traveled by: Exploring a decade of Ellman chemistry
score: 2.4264726, Bioorganic & Medicinal Chemistry, 2009, Shelat, Anang A.; Guy, R. Kiplin
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.4237886, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.4237886, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
score: 2.4236672, European Journal of Medicinal Chemistry, 2012, Xie, Hui et. al.
Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity
score: 2.423349, Bioorganic & Medicinal Chemistry, 2013, Taygerly, Joshua P. et. al.
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents
score: 2.4227221, European Journal of Medicinal Chemistry, 2012, Carvalho, Samir A. et. al.
Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors
score: 2.4227108, Bioorganic & Medicinal Chemistry Letters, 2012, Miller, Michael M. et. al.
Design, synthesis and biological activity of acyl substituted 3-amino-5-methyl-1,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones as potential hypnotic drugs
score: 2.4219023, European Journal of Medicinal Chemistry, 2005, Falcó, José L. et. al.
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
score: 2.4216371, Bioorganic & Medicinal Chemistry Letters, 2012, Tell, Volkmar et. al.
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
score: 2.4216371, Bioorganic & Medicinal Chemistry Letters, 2012, Tell, Volkmar et. al.
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
score: 2.4216371, Bioorganic & Medicinal Chemistry Letters, 2012, Tell, Volkmar et. al.
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
score: 2.4199212, European Journal of Medicinal Chemistry, 2012, Xie, Hui et. al.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
score: 2.419727, Bioorganic & Medicinal Chemistry, 2012, Miyamoto, Naoki et. al.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.4184321, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
Quantitative structure–activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents
score: 2.4182986, Bioorganic & Medicinal Chemistry Letters, 2008, Chen, Ke-xian; Xie, Hai-ying; Li, Zu-guang; Gao, Jian-rong
Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum
score: 2.4156656, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Nitro and amino substitution within the A-ring of 5 H-8,9-dimethoxy-5-(2- N, N-dimethylaminoethyl)dibenzo[ c, h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity
score: 2.4144669, Bioorganic & Medicinal Chemistry, 2004, Ruchelman, Alexander L et. al.
3D-QSAR CoMFA, CoMSIA studies on substituted ureas as Raf-1 kinase inhibitors and its confirmation with structure-based studies
score: 2.412264, Bioorganic & Medicinal Chemistry, 2004, Thaimattam, Ram et. al.
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques
score: 2.4111963, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yao et. al.
Highly potent aminopyridines as Syk kinase inhibitors
score: 2.4103797, Bioorganic & Medicinal Chemistry Letters, 2012, Castillo, Marcos et. al.
Imidazo[1,2- b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors
score: 2.4098122, Bioorganic & Medicinal Chemistry Letters, 2004, Byth, Kate F et. al.
Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3
score: 2.4097846, Bioorganic & Medicinal Chemistry, 2006, Rönn, Robert et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.4081653, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Arylazolyl(azinyl)thioacetanilides. Part 10: Design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors
score: 2.4075472, Bioorganic & Medicinal Chemistry, 2012, Li, Xiao et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
score: 2.4074739, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
score: 2.4074739, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
score: 2.4074739, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Haijun et. al.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
score: 2.4066243, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yingyi et. al.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
score: 2.4066243, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yingyi et. al.
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation
score: 2.4066243, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yingyi et. al.
Design, synthesis, and structure–activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF1 receptor antagonists
score: 2.4060944, Bioorganic & Medicinal Chemistry Letters, 2012, Takeda, Kunitoshi et. al.
Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors
score: 2.4057954, Bioorganic & Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening
score: 2.4042685, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Hwangseo; Chien, Pham Ngoc; Ryu, Seong Eon
Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
score: 2.4036191, Antimicrobial agents and chemotherapy, 2001, Clements, J M et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.4028928, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.4028928, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Inhibitors of lipoprotein(a) assembly
score: 2.4017377, Bioorganic & Medicinal Chemistry, 2003, Sexton, Karen E et. al.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
score: 2.4006976, Bioorganic & Medicinal Chemistry Letters, 2012, Asano, Masayoshi et. al.
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
score: 2.4000524, Bioorganic & Medicinal Chemistry Letters, 2012, Karle, Michael; Knecht, Wolfgang; Xue, Yafeng
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
score: 2.4000524, Bioorganic & Medicinal Chemistry Letters, 2012, Karle, Michael; Knecht, Wolfgang; Xue, Yafeng
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
score: 2.3989784, European Journal of Medicinal Chemistry, 2012, Chini, Maria Giovanna et. al.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
score: 2.3980968, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
score: 2.3980968, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Development of anti-coxsackievirus agents targeting 3C protease
score: 2.3964012, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Bo-Kyoung et. al.
Development of anti-coxsackievirus agents targeting 3C protease
score: 2.3964012, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Bo-Kyoung et. al.
Development of anti-coxsackievirus agents targeting 3C protease
score: 2.3964012, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Bo-Kyoung et. al.
Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051
score: 2.3960152, Bioorganic & Medicinal Chemistry Letters, 2009, Enache, Livia A. et. al.
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
score: 2.3959162, European Journal of Medicinal Chemistry, 2012, Vega, Maria Celeste et. al.
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies
score: 2.3941567, Bioorganic & Medicinal Chemistry Letters, 2012, Arán, Vicente J.; Kaiser, Marcel; Dardonville, Christophe
Potent and selective thrombin inhibitors featuring hydrophobic, basic P 3P 4-aminoalkyllactam moieties
score: 2.3924545, Bioorganic & Medicinal Chemistry Letters, 1998, Semple, J.Edward et. al.
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase
score: 2.3916994, Bioorganic & Medicinal Chemistry, 2005, Levell, Julian et. al.
Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
score: 2.3914352, Bioorganic & Medicinal Chemistry Letters, 2012, Aiguadé, Josep et. al.
Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
score: 2.3914352, Bioorganic & Medicinal Chemistry Letters, 2012, Aiguadé, Josep et. al.
Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
score: 2.3914352, Bioorganic & Medicinal Chemistry Letters, 2012, Aiguadé, Josep et. al.
Characteristics of known drug space. Natural products, their derivatives and synthetic drugs
score: 2.3908575, European Journal of Medicinal Chemistry, 2010, Bade, Richard; Chan, Ho-Fung; Reynisson, Jóhannes
A σ1 receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ols (AHDs)
score: 2.3897253, Bioorganic & Medicinal Chemistry Letters, 2012, Banister, Samuel D. et. al.
Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
score: 2.3891052, Bioorganic & Medicinal Chemistry, 2012, Davies, Nicholas G.M. et. al.
Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
score: 2.3891052, Bioorganic & Medicinal Chemistry, 2012, Davies, Nicholas G.M. et. al.
A novel class of sodium/calcium exchanger inhibitor: design, synthesis, and structure–activity relationships of 3,4-dihydro-2(1 H)-quinazolinone derivatives
score: 2.3886582, Bioorganic & Medicinal Chemistry, 2005, Hasegawa, Hirohiko et. al.
Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance
score: 2.3885521, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance
score: 2.3885521, Bioorganic & Medicinal Chemistry Letters, 2012, Giordanetto, Fabrizio et. al.
Synthesis and docking studies of novel antitumor benzimidazoles
score: 2.384636, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Synthesis and docking studies of novel antitumor benzimidazoles
score: 2.384636, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Synthesis and docking studies of novel antitumor benzimidazoles
score: 2.384636, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid
score: 2.3846004, Bioorganic & Medicinal Chemistry, 2004, El-Araby, Moustafa E et. al.
3D QSAR studies on T-type calcium channel blockers using CoMFA and CoMSIA
score: 2.3838214, Bioorganic & Medicinal Chemistry, 2004, Doddareddy, Munikumar Reddy et. al.
Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1
score: 2.3837959, Bioorganic & Medicinal Chemistry Letters, 2012, Le Brazidec, Jean-Yves et. al.
Two- and three-dimensional quantitative structure–activity relationships for a series of purine nucleoside phosphorylase inhibitors
score: 2.3836733, Bioorganic & Medicinal Chemistry, 2006, Castilho, Marcelo S. et. al.
Contribution of indazolinone tautomers to kinase activity
score: 2.382927, Bioorganic & Medicinal Chemistry Letters, 2012, Vasudevan, Anil et. al.
Contribution of indazolinone tautomers to kinase activity
score: 2.382927, Bioorganic & Medicinal Chemistry Letters, 2012, Vasudevan, Anil et. al.
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
score: 2.381945, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Yu Min et. al.
Inhibitors of HIV-1 attachment. Part 11: The discovery and structure–activity relationships associated with 4,6-diazaindole cores
score: 2.3810729, Bioorganic & Medicinal Chemistry Letters, 2013, Bender, John A. et. al.
Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides
score: 2.3807651, Bioorganic & Medicinal Chemistry Letters, 2010, Ali, Abdelselam et. al.
Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation
score: 2.3787954, Bioorganic & Medicinal Chemistry Letters, 2012, Ellard, Katie et. al.
Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation
score: 2.3787954, Bioorganic & Medicinal Chemistry Letters, 2012, Ellard, Katie et. al.
Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower log D limits based on permeability
score: 2.3774229, Bioorganic & Medicinal Chemistry Letters, 2009, Waring, Michael J.
Combining pharmacophore, docking and substructure search approaches to identify and optimize novel B-RafV600E inhibitors
score: 2.3774138, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Zhijian et. al.
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailablemPGES-1 inhibitor for the potential treatment of inflammation
score: 2.3771681, Bioorganic & Medicinal Chemistry Letters, 2013, Arhancet, Graciela B. et. al.
Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
score: 2.376364, European Journal of Medicinal Chemistry, 2012, Shen, Shi-Li et. al.
Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase
score: 2.3763355, Bioorganic & Medicinal Chemistry, 2003, Mano, Takashi et. al.
Structure–activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives
score: 2.3758638, Bioorganic & Medicinal Chemistry Letters, 2012, Ikeda, Reiko et. al.
Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency
score: 2.3757491, Bioorganic & Medicinal Chemistry Letters, 2013, Bollini, Mariela et. al.
Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors
score: 2.3756723, Bioorganic & Medicinal Chemistry, 2006, Shinji, Chihiro et. al.
Design and synthesis of acyclic triaryl ( Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors
score: 2.3732083, Bioorganic & Medicinal Chemistry, 2004, Uddin, Md. Jashim; Rao, P.N. Praveen; Knaus, Edward E.
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives
score: 2.373044, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives
score: 2.373044, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives
score: 2.373044, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: Identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid
score: 2.3715975, Bioorganic & Medicinal Chemistry Letters, 2013, Lee, Kijae et. al.
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors
score: 2.3714893, Bioorganic & Medicinal Chemistry, 2012, Ohashi, Tomohiro et. al.
Synthesis of 1,1-difluoro-5-(1 H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase
score: 2.3713539, Bioorganic & Medicinal Chemistry, 1998, Yokomatsu, Tsutomu et. al.
Computational design of novel fullerene analogues as potential HIV-1 PR inhibitors: Analysis of the binding interactions between fullerene inhibitors and HIV-1 PR residues using 3D QSAR, molecular docking and molecular dynamics simulations
score: 2.3709515, Bioorganic & Medicinal Chemistry, 2008, Durdagi, Serdar et. al.
Construction of a virtual combinatorial library using SMILES strings to discover potential structure-diverse PPAR modulators
score: 2.3682812, European Journal of Medicinal Chemistry, 2005, Liao, Chenzhong et. al.
New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 2: Synthesis and structure–activity relationships in the S-3578 series
score: 2.3672112, Bioorganic & Medicinal Chemistry, 2004, Yoshizawa, Hidenori et. al.
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines
score: 2.3655796, Bioorganic & Medicinal Chemistry Letters, 2012, Lombardo, Caterina M. et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.3655571, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.3655571, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.3655571, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
1,3-Azoles from ortho-naphthoquinones: Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis
score: 2.3642119, Bioorganic & Medicinal Chemistry, 2012, Moura, Kelly C.G. et. al.
1,3-Azoles from ortho-naphthoquinones: Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis
score: 2.3642119, Bioorganic & Medicinal Chemistry, 2012, Moura, Kelly C.G. et. al.
9- cis-Retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists
score: 2.3633705, Bioorganic & Medicinal Chemistry Letters, 2004, Alvarez, Rosana et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3633575, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3633575, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3633575, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors
score: 2.3624538, Bioorganic & Medicinal Chemistry Letters, 2013, Jin, Meizhong et. al.
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors
score: 2.3624538, Bioorganic & Medicinal Chemistry Letters, 2013, Jin, Meizhong et. al.
3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors
score: 2.3616176, European Journal of Medicinal Chemistry, 2006, Singh, S.K.; Dessalew, N.; Bharatam, P.V.
Dimerization of β-tryptase inhibitors, does it work for both basic and neutral P1 groups?
score: 2.3612727, Bioorganic & Medicinal Chemistry Letters, 2012, Liang, Guyan et. al.
Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
score: 2.3604351, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Xiao-Guang et. al.
Design, synthesis and anticancer activity of 1-acyl-3-amino- 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
score: 2.3604351, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Xiao-Guang et. al.
Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
score: 2.3604351, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Xiao-Guang et. al.
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase
score: 2.3601746, Bioorganic & Medicinal Chemistry, 1997, Gallagher, Timothy F. et. al.
The Discovery of YM-60828: A Potent, Selective and Orally-Bioavailable Factor Xa Inhibitor
score: 2.3596056, Bioorganic & Medicinal Chemistry, 2002, Hirayama, Fukushi et. al.
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies
score: 2.3547252, Bioorganic & Medicinal Chemistry Letters, 2012, Arán, Vicente J.; Kaiser, Marcel; Dardonville, Christophe
3D-QSAR and molecular docking study on bisarylmaleimide series as glycogen synthase kinase 3, cyclin dependent kinase 2 and cyclin dependent kinase 4 inhibitors: An insight into the criteria for selectivity
score: 2.3540018, European Journal of Medicinal Chemistry, 2007, Dessalew, Nigus; Bharatam, Prasad V.
Contribution of Indazolinone Tautomers to Kinase Activity
score: 2.3530493, Bioorganic & Medicinal Chemistry Letters, 2012, Vasudevan, Anil et. al.
A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: Design, synthesis and molecular modeling study
score: 2.3506185, European Journal of Medicinal Chemistry, 2012, Huang, Dawei; Li, Xiaohui; Wei, Yingdong; Xiu, Zhilong
Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents
score: 2.3495253, Bioorganic & Medicinal Chemistry Letters, 2013, Kamal, Ahmed et. al.
Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity
score: 2.34903, Bioorganic & Medicinal Chemistry, 2000, Suich, Daniel J et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.3475755, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.3475755, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.3475755, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives
score: 2.347437, Bioorganic & Medicinal Chemistry, 1998, Cho, Won-Jea et. al.
Discovery of Nitroheterocycles Active against African Trypanosomes. In Vitro Screening and Preliminary SAR Studies
score: 2.3473018, Bioorganic & Medicinal Chemistry Letters, 2012, Arán, Vicente J.; Kaiser, Marcel; Dardonville, Christophe
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
score: 2.3467509, Bioorganic & Medicinal Chemistry Letters, 2012, Chapman, Timothy M. et. al.
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
score: 2.3467509, Bioorganic & Medicinal Chemistry Letters, 2012, Chapman, Timothy M. et. al.
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor
score: 2.3463499, Bioorganic & Medicinal Chemistry Letters, 2012, Cumming, Jared N. et. al.
Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors
score: 2.3458221, Bioorganic & Medicinal Chemistry Letters, 2012, Matsufuji, Tetsuyoshi et. al.
The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors
score: 2.3454637, Bioorganic & Medicinal Chemistry Letters, 2013, Tang, Jun; Lackey, Karen E.; Dickerson, Scott H.
New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase
score: 2.3454407, Bioorganic & Medicinal Chemistry, 1997, Bonnet, Béatrice et. al.
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
score: 2.3452328, European Journal of Medicinal Chemistry, 2012, Lukasik, Pawel M. et. al.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs
score: 2.3441549, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Cuihua et. al.
Synthesis and antibacterial activity of new N-linked 5-triazolylmethyl oxazolidinones
score: 2.3432836, Bioorganic & Medicinal Chemistry, 2005, Phillips, Oludotun A. et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3421099, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3421099, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy
score: 2.339634, Bioorganic & Medicinal Chemistry Letters, 2012, Zhou, Ting et. al.
Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding
score: 2.3396016, European Journal of Medicinal Chemistry, 2012, Uttekar, Mayur M. et. al.
Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding
score: 2.3396016, European Journal of Medicinal Chemistry, 2012, Uttekar, Mayur M. et. al.
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety
score: 2.3390137, Bioorganic & Medicinal Chemistry, 2013, Konno, Sho et. al.
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
score: 2.3388815, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities
score: 2.338586, Bioorganic & Medicinal Chemistry, 2004, Kurimoto, Ayumu et. al.
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators
score: 2.33778, European Journal of Medicinal Chemistry, 2012, Visentin, Sonja et. al.
Synthesis, Structure-Activity Relationships and Biological Evaluation of Caudatin Derivatives as Novel Anti-Hepatitis B Virus Agents
score: 2.337674, Bioorganic & Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications
score: 2.3345063, Bioorganic & Medicinal Chemistry, 2004, Van Zandt, Michael C. et. al.
Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents
score: 2.3343342, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents
score: 2.3343342, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents
score: 2.3343342, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure–activity relationships of 4-azaindole cores
score: 2.3343177, Bioorganic & Medicinal Chemistry Letters, 2013, Wang, Tao et. al.
Design of EGFR kinase inhibitors: A ligand-based approach and its confirmation with structure-based studies
score: 2.3340042, Bioorganic & Medicinal Chemistry, 2003, Vema, Aparna et. al.
Design, synthesis, antimicrobial, anti-inflammatory and analgesic activity of novel isoxazolyl pyrimido[4,5-b]quinolines and isoxazolyl chromeno[2,3-d]pyrimidin-4-ones
score: 2.3337745, European Journal of Medicinal Chemistry, 2012, Rajanarendar, E. et. al.
New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies
score: 2.3324474, European Journal of Medicinal Chemistry, 2006, Aguirre, Gabriela et. al.
Structure–activity relationship of natural and synthetic coumarins inhibiting the multidrug transporter P-glycoprotein
score: 2.3324349, Bioorganic & Medicinal Chemistry, 2006, Raad, Imad et. al.
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
score: 2.3319637, Bioorganic & Medicinal Chemistry Letters, 2012, Han, Sun-Young et. al.
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
score: 2.3319637, Bioorganic & Medicinal Chemistry Letters, 2012, Han, Sun-Young et. al.
Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter
score: 2.3316191, Bioorganic & Medicinal Chemistry, 2003, Kimura, Makoto et. al.
Synthesis of Tumor-Associated Glycopeptide Antigens
score: 2.3315631, Bioorganic & Medicinal Chemistry, 2002, Brocke, Constanze; Kunz, Horst
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors
score: 2.3312031, Bioorganic & Medicinal Chemistry Letters, 2012, Zych, Andrew J. et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.3304706, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.3304706, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.3304706, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
score: 2.3296783, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Xiao-Dong et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.3292357, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridyl-benzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.3292357, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.3292357, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice
score: 2.3291601, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Liming et. al.
Novel interleukin-5 inhibitors based on hydroxyethylaminomethyl-4H-chromen-4-one scaffold
score: 2.3287092, Bioorganic & Medicinal Chemistry, 2012, Joo, Cheonik et. al.
Discovery of Novel 2-(3-(2-Chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides As Potent HIV-1 Inhibitors Using a Structure-Based Bioisosterism Approach
score: 2.3280813, Bioorganic & Medicinal Chemistry, 2012, Zhan, Peng et. al.
A solid-phase approach to analogues of the antibiotic mureidomycin
score: 2.3270263, Bioorganic & Medicinal Chemistry Letters, 2000, Bozzoli, Andrea et. al.
Facile synthesis and characterization of novel pyrazole-sulfonamides and their inhibition effects on human carbonic anhydrase isoenzymes
score: 2.3257969, Bioorganic & Medicinal Chemistry, 2013, Balseven, Havva et. al.
Synthesis and SAR of Tetrahydroisoquinolines as Rev-erbα agonists
score: 2.325548, Bioorganic & Medicinal Chemistry Letters, 2012, Noel, Romain et. al.
Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors
score: 2.3254085, Bioorganic & Medicinal Chemistry Letters, 2012, Dong, Ming-xin et. al.
Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors
score: 2.3254085, Bioorganic & Medicinal Chemistry Letters, 2012, Dong, Ming-xin et. al.
Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay
score: 2.324481, Bioorganic & Medicinal Chemistry, 2006, Li, Jian et. al.
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.
score: 2.3243564, Antimicrobial agents and chemotherapy, 2003, Shenai, Bhaskar R et. al.
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors
score: 2.323664, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Zaihui et. al.
Synthesis and Biological Activity of 2-Aminothiazoles as Novel Inhibitors of PGE2 Production in Cells
score: 2.3234602, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Breland et. al.
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1
score: 2.3233555, Bioorganic & Medicinal Chemistry Letters, 2013, Evindar, Ghotas et. al.
Quantitative structure–activity relationships for a series of symmetrical bisquaternary anticancer compounds
score: 2.3229428, Bioorganic & Medicinal Chemistry, 2002, Campos, Joaquı́n M. et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3229197, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors
score: 2.3219732, Bioorganic & Medicinal Chemistry Letters, 2013, Ting, Pauline C. et. al.
Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues
score: 2.3218993, Bioorganic & Medicinal Chemistry, 2012, Roman, Bart I. et. al.
Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold
score: 2.3206476, Bioorganic & Medicinal Chemistry Letters, 2013, Valdenaire, Anja et. al.
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis
score: 2.3200872, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Yong-Ming et. al.
Structure–affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of α 1 antagonist WB-4101
score: 2.3199347, Bioorganic & Medicinal Chemistry, 2004, Bolchi, Cristiano et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.3189544, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.3189544, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.3189544, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1
score: 2.3180168, Bioorganic & Medicinal Chemistry Letters, 2012, Mougenot, Patrick et. al.
Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose
score: 2.3179169, Bioorganic & Medicinal Chemistry Letters, 2012, Vaidya, Aditya Sudheer et. al.
Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose
score: 2.3179169, Bioorganic & Medicinal Chemistry Letters, 2012, Vaidya, Aditya Sudheer et. al.
Novel potent and selective α vβ 3/α vβ 5 integrin dual antagonists with reduced binding affinity for human serum albumin
score: 2.3166112, European Journal of Medicinal Chemistry, 2006, Raboisson, Pierre et. al.
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
score: 2.3165743, Bioorganic & Medicinal Chemistry Letters, 2012, Winum, Jean-Yves et. al.
Synthesis, biological activity and receptor-based 3-D QSAR study of 3′- N-substituted-3′- N-debenzoylpaclitaxel analogues
score: 2.3157242, Bioorganic & Medicinal Chemistry, 2002, Roh, Eun Joo et. al.
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors
score: 2.3156153, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Zaihui et. al.
Synthesis, structure–activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents
score: 2.313643, Bioorganic & Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Synthesis, structure–activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents
score: 2.313643, Bioorganic & Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents
score: 2.3134382, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Yan et. al.
Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARγ modulators
score: 2.3119313, European Journal of Medicinal Chemistry, 2012, Furukawa, Akihiro et. al.
Convenient synthesis and evaluation of glycosidase inhibitory activity of α- and β-galactose-type valienamines, and some N-alkyl derivatives
score: 2.3112198, Bioorganic & Medicinal Chemistry, 2004, Ogawa, Seiichiro et. al.
Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening
score: 2.3097754, European Journal of Medicinal Chemistry, 2012, Estevão, Mónica S. et. al.
Novel and Potent Anti-malarial Agents
score: 2.3097373, Bioorganic & Medicinal Chemistry, 2002, Brinner, Kristin M et. al.
Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents
score: 2.3095798, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents
score: 2.3095798, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents
score: 2.3095798, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives
score: 2.3080064, Bioorganic & Medicinal Chemistry Letters, 2012, Ikeda, Reiko et. al.
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents
score: 2.3076727, European Journal of Medicinal Chemistry, 2012, Carvalho, Samir A. et. al.
Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening
score: 2.3073263, Bioorganic & Medicinal Chemistry, 2006, Foloppe, Nicolas et. al.
Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues
score: 2.3072656, Bioorganic & Medicinal Chemistry, 2012, Roman, Bart I. et. al.
Design, Synthesis and Evaluation of Novel Zwitterionic Compounds as PPARα/γ Dual Agonists (1)
score: 2.3071787, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Synthesis and biological evaluation of novel (−)-cercosporamide derivatives as potent selective PPARγ modulators
score: 2.3066179, European Journal of Medicinal Chemistry, 2012, Furukawa, Akihiro et. al.
New QSPR study for the prediction of aqueous solubility of drug-like compounds
score: 2.3065304, Bioorganic & Medicinal Chemistry, 2008, Duchowicz, Pablo R. et. al.
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ- and δ-lactams via a ‘catch and release’ protocol
score: 2.3059774, Bioorganic & Medicinal Chemistry, 2006, Musonda, Chitalu C. et. al.
Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents
score: 2.3056485, European Journal of Medicinal Chemistry, 2012, Abbassi, Najat et. al.
Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents
score: 2.3056485, European Journal of Medicinal Chemistry, 2012, Abbassi, Najat et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.3053531, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.3053531, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold
score: 2.3038212, Bioorganic & Medicinal Chemistry Letters, 2013, Valdenaire, Anja et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: Effect of dimerisation on phosphatase inhibition
score: 2.3038055, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: Effect of dimerisation on phosphatase inhibition
score: 2.3038055, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: Effect of dimerisation on phosphatase inhibition
score: 2.3038055, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists
score: 2.3024, Bioorganic & Medicinal Chemistry, 1998, Robarge, Kirk D. et. al.
Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand
score: 2.3017834, Bioorganic & Medicinal Chemistry, 2006, Miura, Masanori et. al.
Design and analysis of molecular motifs for specific recognition of RNA
score: 2.3012748, Bioorganic & Medicinal Chemistry, 1997, Fernandez-Saiz, Ke Li M. et. al.
Synthesis, characterization and antimalarial activity of quinoline–pyrimidine hybrids
score: 2.3006159, Bioorganic & Medicinal Chemistry, 2013, Pretorius, Stefan I. et. al.
Novel triazines as potent and selective phosphodiesterase 10A inhibitors
score: 2.3001789, Bioorganic & Medicinal Chemistry Letters, 2012, Malamas, Michael S. et. al.
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases
score: 2.2995765, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Tao et. al.
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties
score: 2.2992818, Bioorganic & Medicinal Chemistry Letters, 2013, Butini, Stefania et. al.
Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold
score: 2.2986835, European Journal of Medicinal Chemistry, 2012, Al-Horani, Rami A.; Mehta, Akul Y.; Desai, Umesh R.
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors
score: 2.2984298, Bioorganic & Medicinal Chemistry Letters, 2012, Basu, Sujay et. al.
Structure–activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors
score: 2.2981661, Bioorganic & Medicinal Chemistry, 2004, Ockey, Denise A et. al.
Synthesis and evaluation of pyridylbenzofuran, pyridyl-benzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques
score: 2.297908, Bioorganic & Medicinal Chemistry Letters, 2012, Swahn, Britt-Marie et. al.
N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.
score: 2.2976833, Antimicrobial agents and chemotherapy, 2002, Hackbarth, Corinne J et. al.
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
score: 2.2961445, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Yusuke et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.2956731, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.2956731, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.2956731, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
Pharmacophores modeling in terms of prediction of theoretical physico-chemical properties and verification by experimental correlations of novel coumarin derivatives produced via Betti’s protocol
score: 2.2953207, European Journal of Medicinal Chemistry, 2010, Parvez, Ali et. al.
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability
score: 2.2951864, Bioorganic & Medicinal Chemistry, 2006, Staas, Donnette D. et. al.
Structure-based optimization of aminopyridines as PKCθ inhibitors
score: 2.2947119, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Juan-Miguel et. al.
Structure-based optimization of aminopyridines as PKCθ inhibitors
score: 2.2947119, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Juan-Miguel et. al.
Chiral 3,3′-(1,2-Ethanediyl)-bis[2-(3,4-dimethoxyphenyl)-4-thiazolidinones] with anti-inflammatory activity. Part 11: Evaluation of COX-2 selectivity and modelling
score: 2.2937075, Bioorganic & Medicinal Chemistry, 2003, Vigorita, M.G et. al.
Automated generation of turn mimetics: Proof of concept study for the MC4 receptor
score: 2.2914109, Bioorganic & Medicinal Chemistry, 2012, Baber, J. Christian et. al.
Automated generation of turn mimetics: Proof of concept study for the MC4 receptor
score: 2.2914109, Bioorganic & Medicinal Chemistry, 2012, Baber, J. Christian et. al.
Automated generation of turn mimetics: Proof of concept study for the MC4 receptor
score: 2.2914109, Bioorganic & Medicinal Chemistry, 2012, Baber, J. Christian et. al.
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.2889956, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.2889956, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
3-D-QSAR Analysis of N-(3-Acyloxy-2-benzylpropyl)- N′-dihydroxytetrahydrobenzazepine and Tetrahydroisoquinoline and N-(3-Acyloxy-2-benzylpropyl)- N′-(4-hydroxy-3-methoxybenzyl) Thioureas Analogues as Potent Vanilloid Receptor Ligands
score: 2.288465, Bioorganic & Medicinal Chemistry, 2002, Kim, Ki H.
Synthesis, pharmacology and molecular modeling of N-substituted 2-phenyl-indoles and benzimidazoles as potent GABA A agonists
score: 2.2874282, European Journal of Medicinal Chemistry, 2006, Falcó, José Luis et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.2874207, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4 H-pyrrolo[1,2- b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
score: 2.2873349, Bioorganic & Medicinal Chemistry Letters, 2004, Scott Sawyer, J. et. al.
3D QSAR CoMFA/CoMSIA, molecular docking and molecular dynamics studies of fullerene-based HIV-1 PR inhibitors
score: 2.2872006, Bioorganic & Medicinal Chemistry Letters, 2008, Durdagi, Serdar et. al.
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors
score: 2.2869479, Bioorganic & Medicinal Chemistry Letters, 2012, Zych, Andrew J. et. al.
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors
score: 2.2869479, Bioorganic & Medicinal Chemistry Letters, 2012, Zych, Andrew J. et. al.
Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity
score: 2.2855378, Bioorganic & Medicinal Chemistry Letters, 2012, Ryabtsova, Oxana et. al.
Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity
score: 2.2855378, Bioorganic & Medicinal Chemistry Letters, 2012, Ryabtsova, Oxana et. al.
Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity
score: 2.2855378, Bioorganic & Medicinal Chemistry Letters, 2012, Ryabtsova, Oxana et. al.
Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors
score: 2.2853772, Bioorganic & Medicinal Chemistry, 1997, Reuveni, Hadas et. al.
Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents
score: 2.2850944, Bioorganic & Medicinal Chemistry, 2005, Velázquez, Carlos et. al.
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
score: 2.2849291, Bioorganic & Medicinal Chemistry Letters, 2012, Winum, Jean-Yves et. al.
3,3′-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding
score: 2.2846124, Bioorganic & Medicinal Chemistry Letters, 2012, Weiser, Patrick T. et. al.
Synthesis and evaluation of molluscicidal and larvicidal activities of some novel enaminones derived from 4-hydroxyquinolinones: Part IX
score: 2.2843727, Bioorganic & Medicinal Chemistry, 2005, Abass, Mohamed; Mostafa, Bayaumy B.
A novel aminopeptidase N inhibitor developed by virtual screening approach
score: 2.2840213, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Jinhong et. al.
Anticancer thiopyrano[2,3- d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies
score: 2.2833627, Bioorganic & Medicinal Chemistry, 2006, Lesyk, Roman et. al.
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4- N-methylamino-4,5,6,7-tetrahydrobenzo[ d]isoxazol-3-ol analogues
score: 2.2833355, Bioorganic & Medicinal Chemistry, 2005, Clausen, Rasmus P. et. al.
5-Substituted-1 H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods
score: 2.281937, Bioorganic & Medicinal Chemistry, 2002, Herr, R.Jason
Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors
score: 2.2795197, Bioorganic & Medicinal Chemistry Letters, 2012, Vontzalidou, Argyro et. al.
Part 3: Synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid
score: 2.2774589, Bioorganic & Medicinal Chemistry, 2005, Hazeldine, Stuart T. et. al.
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo–keto reductase AKR1C3
score: 2.2771984, Bioorganic & Medicinal Chemistry Letters, 2012, Sinreih, Maša et. al.
5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials
score: 2.2768828, Bioorganic & Medicinal Chemistry Letters, 2012, Zvarec, Ondrej et. al.
Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1
score: 2.2766853, Bioorganic & Medicinal Chemistry, 2012, Mikstacka, Renata et. al.
Synthesis and in vitro antitumor activity of novel scopoletin derivatives
score: 2.2752789, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Wukun et. al.
Identification of Novel Series of Pyrazole and Indole-Urea based DFG-out PYK2 Inhibitors
score: 2.2722694, Bioorganic & Medicinal Chemistry Letters, 2012, Bhattacharya, Samit K. et. al.
Synthesis of gatifloxacin derivatives and their biological activities againstMycobacterium lepraeandMycobacterium tuberculosis
score: 2.2721256, Bioorganic & Medicinal Chemistry, 2013, Gomez, Catherine et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.2714266, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.2714266, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.2714266, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
score: 2.2699405, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)- podophyllotoxin derivatives
score: 2.2697188, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Jie; Wu, Lin; Xin, Wen Qun; Chen, Xin; Hu, Kun
Design and synthesis of C-linked fucosides as inhibitors of E-selectin
score: 2.2691754, Bioorganic & Medicinal Chemistry, 1996, Uchiyama, Taketo et. al.
Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors
score: 2.2689849, Bioorganic & Medicinal Chemistry Letters, 2009, Shi, Shuhao et. al.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
score: 2.2687011, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 2.2671979, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 2.2671979, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 2.2671979, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
De novo design and synthesis of HIV-1 integrase inhibitors
score: 2.2666868, Bioorganic & Medicinal Chemistry, 2004, Makhija, Mahindra T et. al.
3D-QSAR and docking studies of aldehyde inhibitors of human cathepsin K
score: 2.2666475, Bioorganic & Medicinal Chemistry, 2006, Pan, Xulin et. al.
Design, synthesis, computational and biological evaluation of new anxiolytics
score: 2.2652463, Bioorganic & Medicinal Chemistry, 2004, Geronikaki, Athina et. al.
Three-dimensional quantitative structure-activity relationship and comparative molecular field analysis of dipeptide hydroxamic acid Helicobacter pylori urease inhibitors.
score: 2.264468, Antimicrobial agents and chemotherapy, 2002, Mishra, Hetal; Parrill, Abby L; Williamson, John S
3D-QSAR Study on dihydro-1,3,5-triazines and their spiro derivatives as DHFR inhibitors by comparative molecular field analysis (CoMFA)
score: 2.2639476, Bioorganic & Medicinal Chemistry Letters, 2012, Ma, Xiang; Xiang, Guangya; Yap, Chun-Wei; Chui, Wai-Keung
3D-QSAR Study on dihydro-1,3,5-triazines and their spiro derivatives as DHFR inhibitors by comparative molecular field analysis (CoMFA)
score: 2.2639476, Bioorganic & Medicinal Chemistry Letters, 2012, Ma, Xiang; Xiang, Guangya; Yap, Chun-Wei; Chui, Wai-Keung
Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): Molecular docking and 3D-QSAR analyses on DHDMBF analogues
score: 2.2633546, Bioorganic & Medicinal Chemistry, 2006, Zheng, Mingyue et. al.
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton
score: 2.2621792, Bioorganic & Medicinal Chemistry, 2012, Liu, Chang et. al.
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton
score: 2.2621792, Bioorganic & Medicinal Chemistry, 2012, Liu, Chang et. al.
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton
score: 2.2621792, Bioorganic & Medicinal Chemistry, 2012, Liu, Chang et. al.
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.26163, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors
score: 2.2611598, Bioorganic & Medicinal Chemistry Letters, 2012, Bell, Kathryn et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2611352, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Synthesis and structure activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent beta isoform selective phosphatidylinositol 3-kinase inhibitors
score: 2.2609097, Bioorganic & Medicinal Chemistry Letters, 2012, Sanchez, Robert M. et. al.
New farnesyltransferase inhibitors in the phenothiazine series
score: 2.2606227, Bioorganic & Medicinal Chemistry Letters, 2012, Belei, Dalila et. al.
New farnesyltransferase inhibitors in the phenothiazine series
score: 2.2606227, Bioorganic & Medicinal Chemistry Letters, 2012, Belei, Dalila et. al.
New farnesyltransferase inhibitors in the phenothiazine series
score: 2.2606227, Bioorganic & Medicinal Chemistry Letters, 2012, Belei, Dalila et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part IV: Preliminary control of α vβ 3 selectivity by meta-oriented substitution
score: 2.2600891, Bioorganic & Medicinal Chemistry, 2006, Kubota, Dai et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 2.2597224, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
score: 2.2587307, Bioorganic & Medicinal Chemistry, 2001, McLay, Iain M. et. al.
Synthesis and biological activities of polyquinoline derivatives: New Bcl-2 family protein modulators
score: 2.2577342, European Journal of Medicinal Chemistry, 2012, Saugues, Emmanuelle et. al.
Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline
score: 2.2572601, Bioorganic & Medicinal Chemistry, 2012, Casagrande, Manolo et. al.
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries
score: 2.2560064, Bioorganic & Medicinal Chemistry Letters, 2012, Rahman, Khondaker M. et. al.
Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry
score: 2.2553654, Bioorganic & Medicinal Chemistry, 1997, Hagishita, Sanji et. al.
A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents
score: 2.255284, European Journal of Medicinal Chemistry, 2012, Kumar, Dalip; Kumar, N. Maruthi; Noel, Brett; Shah, Kavita
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2549718, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2549718, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2549718, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
score: 2.2549365, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
score: 2.2549365, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Yoshihiro et. al.
Antifungal properties of new series of quinoline derivatives
score: 2.2540014, Bioorganic & Medicinal Chemistry, 2006, Musiol, Robert et. al.
Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone
score: 2.2538505, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Xianfeng et. al.
Discovery of 4,5-Diphenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human V 1A Receptor
score: 2.2529958, Bioorganic & Medicinal Chemistry, 2002, Kakefuda, Akio et. al.
2-Aminothiophenes as building blocks in heterocyclic synthesis: Synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives
score: 2.2519538, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
2-Aminothiophenes as building blocks in heterocyclic synthesis: Synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives
score: 2.2519538, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
2-Aminothiophenes as building blocks in heterocyclic synthesis: Synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives
score: 2.2519538, European Journal of Medicinal Chemistry, 2012, Behbehani, Haider et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2514456, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Design, synthesis and antibacterial activities of a series of new 2-oxaisocephems
score: 2.2512502, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Jianbo et. al.
Design of tetrapeptide ligands as inhibitors of the Src SH2 domain
score: 2.250577, Bioorganic & Medicinal Chemistry, 2004, Nam, Nguyen-Hai et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.2503595, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
Enhanced cell permeability of kojic acid–phenylalanine amide with metal complex
score: 2.2499874, Bioorganic & Medicinal Chemistry Letters, 2010, Kwak, Seon-Yeong et. al.
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist
score: 2.2498587, Bioorganic & Medicinal Chemistry Letters, 2005, Weigand, Stefan et. al.
Understanding the antitumor activity of novel tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors using CoMFA and CoMSIA
score: 2.2492938, European Journal of Medicinal Chemistry, 2006, Puntambekar, D.S.; Giridhar, R.; Yadav, M.R.
Novel structural insights for drug design of selective 5-HT 2C inverse agonists from a ligand-biased receptor model
score: 2.2486241, European Journal of Medicinal Chemistry, 2010, Renault, Nicolas et. al.
Quantitative structure-activity relationship studies of a series of sulfa drugs as inhibitors of Pneumocystis carinii dihydropteroate synthetase.
score: 2.2471503, Antimicrobial agents and chemotherapy, 1998, Johnson, T; Khan, I A; Avery, M A; Grant, J; Meshnick, S R
Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
score: 2.246362, Bioorganic & Medicinal Chemistry Letters, 2006, Pereira, Raquel et. al.
Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic—salinomycin
score: 2.246003, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam et. al.
Synthesis and anti-inflammatory activity of a series of N-substituted naproxen glycolamides: Nitric oxide-donor naproxen prodrugs
score: 2.2452119, Bioorganic & Medicinal Chemistry, 2006, Ranatunge, Ramani R. et. al.
Short synthesis and antimalarial activity of fagaronine
score: 2.2439677, Bioorganic & Medicinal Chemistry, 2012, Rivaud, M. et. al.
Short synthesis and antimalarial activity of fagaronine
score: 2.2439677, Bioorganic & Medicinal Chemistry, 2012, Rivaud, M. et. al.
Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin
score: 2.2432805, Bioorganic & Medicinal Chemistry Letters, 2013, Manohar, Sunny et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2432149, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
score: 2.2432149, Bioorganic & Medicinal Chemistry Letters, 2012, Schroeder, Gretchen M. et. al.
Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria
score: 2.2428249, Bioorganic & Medicinal Chemistry, 2001, Lee, Chi Sing et. al.
Design, synthesis and molecular docking of α,β-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity
score: 2.2418683, Bioorganic & Medicinal Chemistry, 2013, Xu, Yun-Yun et. al.
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors
score: 2.2415612, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors
score: 2.2415612, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors
score: 2.2415612, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qingwei et. al.
Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
score: 2.2415446, Bioorganic & Medicinal Chemistry Letters, 2012, Prashanth, M.K. et. al.
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
score: 2.2395414, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
score: 2.2395414, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
score: 2.2395414, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
Design, Prins-cyclization reaction promoting diastereoselective synthesis of 10 new tetrahydropyran derivatives and in vivo antinociceptive evaluations
score: 2.239081, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Design, Prins-cyclization reaction promoting diastereoselective synthesis of 10 new tetrahydropyran derivatives and in vivo antinociceptive evaluations
score: 2.239081, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Isochromanone-based urotensin-II receptor agonists
score: 2.2387859, Bioorganic & Medicinal Chemistry, 2005, Lehmann, Fredrik et. al.
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
score: 2.2380216, Bioorganic & Medicinal Chemistry, 2012, B-Rao, Chandrika et. al.
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
score: 2.2380216, Bioorganic & Medicinal Chemistry, 2012, B-Rao, Chandrika et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.2368958, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
A novel series of L-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study
score: 2.2363152, European Journal of Medicinal Chemistry, 2012, Huang, Dawei; Li, Xiaohui; Wei, Yingdong; Xiu, Zhilong
A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study
score: 2.2355691, European Journal of Medicinal Chemistry, 2012, Huang, Dawei; Li, Xiaohui; Wei, Yingdong; Xiu, Zhilong
Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold
score: 2.2342145, Bioorganic & Medicinal Chemistry Letters, 2013, Gao, Ling-Jie et. al.
Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase
score: 2.2320816, Bioorganic & Medicinal Chemistry Letters, 2012, Xin, Botao et. al.
Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase
score: 2.2320816, Bioorganic & Medicinal Chemistry Letters, 2012, Xin, Botao et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part 2: Synthesis of potent α vβ 3/α IIbβ 3 dual antagonists
score: 2.2315461, Bioorganic & Medicinal Chemistry, 2006, Ishikawa, Minoru et. al.
7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1 H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V 2 receptor antagonist
score: 2.2310612, Bioorganic & Medicinal Chemistry, 1999, Kondo, Kazumi et. al.
Rapid microwave-assisted fluorination yielding novel 5′-deoxy-5′-fluorouridine derivatives
score: 2.2302321, Bioorganic & Medicinal Chemistry Letters, 2006, Le, H. Phuoc; Müller, Christa E.
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents
score: 2.2300741, European Journal of Medicinal Chemistry, 2012, Tonk, Rajiv Kumar et. al.
A Novel Series of Pyrazolylpiperidine N-Type Calcium Channel Blockers
score: 2.2289401, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
score: 2.2282979, Bioorganic & Medicinal Chemistry Letters, 2012, Escribano, Ana et. al.
Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors
score: 2.2271863, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Kui et. al.
Potent and Selective Inhibitors of PI3Kδ: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
score: 2.2270825, Bioorganic & Medicinal Chemistry Letters, 2012, Sutherlin, Daniel P. et. al.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
score: 2.225402, Bioorganic & Medicinal Chemistry Letters, 2012, Bonn, Peter et. al.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
score: 2.225402, Bioorganic & Medicinal Chemistry Letters, 2012, Bonn, Peter et. al.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
score: 2.225402, Bioorganic & Medicinal Chemistry Letters, 2012, Bonn, Peter et. al.
A natural product inspired hybrid approach towards the synthesis of novel pentamidine based scaffolds as potential anti-parasitic agents
score: 2.2252982, Bioorganic & Medicinal Chemistry Letters, 2013, Tyagi, Vikas et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
score: 2.2252869, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Tiansheng et. al.
Discovery of Benzothiazole Guanidines as Novel Inhibitors of Thrombin and Trypsin IV
score: 2.2251341, Bioorganic & Medicinal Chemistry Letters, 2012, Karle, Michael; Knecht, Wolfgang; Xue, Yafeng
Synthesis of an α-kojibiosyl substituted glycerol teichoic acid hexamer
score: 2.2243956, Bioorganic & Medicinal Chemistry, 2010, Hogendorf, Wouter F.J. et. al.
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
score: 2.2238321, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Substituted hepta-1,6-dien-3-ones with green/fruity odours green/galbanum olfactophore model
score: 2.2237475, Bioorganic & Medicinal Chemistry, 2003, Bajgrowicz, Jerzy A; Berg-Schultz, Katja; Brunner, Gerhard
O-Aryl α,β-D-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2236064, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy
score: 2.2235606, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yuusuke et. al.
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy
score: 2.2235606, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yuusuke et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 2.2233331, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 2.2233331, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR
score: 2.2224282, Bioorganic & Medicinal Chemistry Letters, 2012, Bregman, Howard et. al.
Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Synthesis and structure–activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives
score: 2.2223436, Bioorganic & Medicinal Chemistry, 2005, Masuda, Naoyuki et. al.
Synthesis of 6-Substituted 9-Methoxy-11H-indeno[1,2-c]quinoline-11-one Derivatives as Potential Anticancer Agents
score: 2.2218378, Bioorganic & Medicinal Chemistry, 2012, Tseng, Chih-Hua et. al.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
score: 2.2216095, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel J. et. al.
Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm
score: 2.2216086, Bioorganic & Medicinal Chemistry Letters, 2006, Yuan, Hongbin; Petukhov, Pavel A.
Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents
score: 2.2215112, Bioorganic & Medicinal Chemistry, 1997, Li, Hui-Yin et. al.
Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY
score: 2.2214809, Bioorganic & Medicinal Chemistry, 2012, Papst, Stefanie et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.2207816, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.2207816, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.2207816, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-α-threofuranosyl ring systems: interactions with P2Y receptors
score: 2.2205305, Bioorganic & Medicinal Chemistry, 2004, Ohno, Michihiro et. al.
Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity
score: 2.2204548, Bioorganic & Medicinal Chemistry, 2003, Moosavi-Movahedi, Ali A et. al.
Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 2.2196644, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 2.2196644, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 2.2196644, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors
score: 2.219609, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors
score: 2.219609, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors
score: 2.219609, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
Synthesis and structure–activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors
score: 2.2196075, Bioorganic & Medicinal Chemistry Letters, 2012, Sanchez, Robert M. et. al.
Synthesis and structure–activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors
score: 2.2196075, Bioorganic & Medicinal Chemistry Letters, 2012, Sanchez, Robert M. et. al.
Identification of novel chromenone derivatives as interleukin-5 inhibitors
score: 2.2190259, European Journal of Medicinal Chemistry, 2013, Venkateswararao, Eeda et. al.
Identification of novel chromenone derivatives as interleukin-5 inhibitors
score: 2.2190259, European Journal of Medicinal Chemistry, 2013, Venkateswararao, Eeda et. al.
Design and synthesis of Pictet–Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death
score: 2.2162141, Bioorganic & Medicinal Chemistry Letters, 2012, Skouta, Rachid et. al.
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450
score: 2.2138429, Bioorganic & Medicinal Chemistry, 2006, Labrie, Philippe et. al.
C 17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C 17,20-lyase inhibitors
score: 2.2135427, Bioorganic & Medicinal Chemistry, 2004, Matsunaga, Nobuyuki et. al.
A general method for the synthesis of aryl [ 11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression
score: 2.2129793, Bioorganic & Medicinal Chemistry Letters, 2005, Majo, Vattoly J. et. al.
O-Aryl α,β-d-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2122579, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
O-Aryl α,β-d-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2122579, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
O-Aryl α,β-d-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity
score: 2.2122579, Bioorganic & Medicinal Chemistry, 2012, Sharma, Raman K. et. al.
Analogs of N′-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 2.2117791, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Analogs of N′-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 2.2117791, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Selective anti-tubercular purines: Synthesis and chemotherapeutic properties of 6-aryl- and 6-heteroaryl-9-benzylpurines
score: 2.210964, Bioorganic & Medicinal Chemistry, 2005, Brændvang, Morten; Gundersen, Lise-Lotte
Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety
score: 2.2108457, Bioorganic & Medicinal Chemistry Letters, 2012, Arai, Tadamasa et. al.
Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety
score: 2.2108457, Bioorganic & Medicinal Chemistry Letters, 2012, Arai, Tadamasa et. al.
Design, synthesis and structure–activity relationships of novel benzoxazolone derivatives as 18kDa translocator protein (TSPO) ligands
score: 2.2107014, Bioorganic & Medicinal Chemistry, 2012, Fukaya, Takayuki et. al.
Novel 3-substituted-1-aryl-5-phenyl-6-anilinopyrazolo[3,4-d]pyrimidin-4-ones: Docking, synthesis and pharmacological evaluation as a potential anti-inflammatory agents
score: 2.2103105, Bioorganic & Medicinal Chemistry Letters, 2012, Yewale, Sandeep B. et. al.
Novel 3-substituted-1-aryl-5-phenyl-6-anilinopyrazolo[3,4-d]pyrimidin-4-ones: Docking, synthesis and pharmacological evaluation as a potential anti-inflammatory agents
score: 2.2103105, Bioorganic & Medicinal Chemistry Letters, 2012, Yewale, Sandeep B. et. al.
Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity
score: 2.2088508, Bioorganic & Medicinal Chemistry, 2012, Erić, Slavica et. al.
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood–brain barrier choline transporter
score: 2.2081262, Bioorganic & Medicinal Chemistry, 2005, Geldenhuys, Werner J. et. al.
Synthesis and Docking Studies of Novel Antitumor Benzimidazoles
score: 2.2074251, Bioorganic & Medicinal Chemistry, 2012, Omar, Mohamed A. et. al.
Identification ofN-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual acting α4β1 and α4β7 receptor antagonists
score: 2.2062112, Bioorganic & Medicinal Chemistry Letters, 2013, Tilley, Jefferson W. et. al.
Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques
score: 2.2060498, Bioorganic & Medicinal Chemistry Letters, 2005, Gil, Carmen; Dorronsoro, Isabel; Castro, Ana; Martinez, Ana
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.2053586, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Design, synthesis and evaluation of novel metalloproteinase inhibitors based on l-tyrosine scaffold
score: 2.2051207, Bioorganic & Medicinal Chemistry, 2012, Cheng, Xian-Chao et. al.
Database of bioactive ring systems with calculated properties and its use in bioisosteric design and scaffold hopping
score: 2.2048883, Bioorganic & Medicinal Chemistry, 2012, Ertl, Peter
Analogs of N′-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 2.2037959, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.2029379, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.2029379, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
score: 2.2029379, Bioorganic & Medicinal Chemistry Letters, 2012, Annadurai, Sivakumar et. al.
A novel class of small-molecule Caspase-3 inhibitors prepared by multicomponent reactions
score: 2.2029285, European Journal of Medicinal Chemistry, 2012, Zhu, Qiuhua et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.2028581, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.2028581, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.2028581, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Small molecule inhibitors of the HPV16-E6 interaction with caspase 8
score: 2.2026967, Bioorganic & Medicinal Chemistry Letters, 2012, Yuan, Chung-Hsiang et. al.
Design and Synthesis of Carbamate and Thiocarbamate Derivatives and Their Inhibitory Activities of NO Production in LPS Activated Macrophages
score: 2.201709, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Guo Hua et. al.
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: Methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones
score: 2.2014997, Bioorganic & Medicinal Chemistry, 2012, Manivannan, E.; Chaturvedi, S.C.
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: Methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones
score: 2.2014997, Bioorganic & Medicinal Chemistry, 2012, Manivannan, E.; Chaturvedi, S.C.
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: Methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones
score: 2.2014997, Bioorganic & Medicinal Chemistry, 2012, Manivannan, E.; Chaturvedi, S.C.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.2013219, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Computational design of novel, high-affinity neuraminidase inhibitors for H5N1 avian influenza virus
score: 2.2011454, European Journal of Medicinal Chemistry, 2010, Park, Jin Woo; Jo, Won Ho
Synthesis, pharmacological evaluation, and structure–activity relationships of benzopyran derivatives with potent SERM activity
score: 2.2004418, Bioorganic & Medicinal Chemistry, 2004, Amari, Gabriele et. al.
Drug discovery and development for neglected parasitic diseases.
score: 2.2001399, Nature chemical biology, 2006, Renslo, Adam R; McKerrow, James H
5-(1,3-Benzothiazol-6-yl)-4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazole Derivatives as Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitors
score: 2.1994156, Bioorganic & Medicinal Chemistry, 2012, Amada, Hideaki et. al.
Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design
score: 2.1992734, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design
score: 2.1992734, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Novel prodrug approach to amprenavir-based HIV-1 protease inhibitors via O→ N acyloxy migration of P1 moiety
score: 2.1985691, Bioorganic & Medicinal Chemistry Letters, 2003, Kazmierski, Wieslaw M et. al.
Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3- d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents
score: 2.1983363, Bioorganic & Medicinal Chemistry, 2006, Gangjee, Aleem; Yang, Jie; Queener, Sherry F.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor
score: 2.1978001, Bioorganic & Medicinal Chemistry Letters, 2012, Finlay, M. Raymond V. et. al.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor
score: 2.1978001, Bioorganic & Medicinal Chemistry Letters, 2012, Finlay, M. Raymond V. et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.197635, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.197635, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.197635, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure–activity study
score: 2.197571, Bioorganic & Medicinal Chemistry, 2012, Chorell, Erik et. al.
Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure–activity study
score: 2.197571, Bioorganic & Medicinal Chemistry, 2012, Chorell, Erik et. al.
Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases
score: 2.1968837, European Journal of Medicinal Chemistry, 2009, Politi, Aggeliki et. al.
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi
score: 2.1966838, Bioorganic & Medicinal Chemistry, 2006, Leite, Ana Cristina Lima et. al.
Structure–activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity
score: 2.1961809, Bioorganic & Medicinal Chemistry, 2006, Xue, Fengtian; Seto, Christopher T.
Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
score: 2.1951708, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
score: 2.1951708, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
score: 2.1951708, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases
score: 2.1946386, Bioorganic & Medicinal Chemistry, 2006, Njar, Vincent C.O. et. al.
β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study
score: 2.1940386, Bioorganic & Medicinal Chemistry Letters, 2012, Du, Jinfa et. al.
Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design
score: 2.1938363, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Identification of Small-Molecule Inhibitors of the Steroidogenic Acute Regulatory Protein (STARD1) by Structure-Based Design
score: 2.1938363, Bioorganic & Medicinal Chemistry Letters, 2012, Akula, Nagaraju et. al.
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists
score: 2.1921802, Bioorganic & Medicinal Chemistry Letters, 2013, Cai, Chaozhong et. al.
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
score: 2.1919358, Bioorganic & Medicinal Chemistry, 2005, Shie, Jiun-Jie et. al.
Synthesis and biological evaluation of novel (−)-cercosporamide derivatives as potent selective PPARγ modulators
score: 2.1915685, European Journal of Medicinal Chemistry, 2012, Furukawa, Akihiro et. al.
Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents
score: 2.190599, European Journal of Medicinal Chemistry, 2012, Abbassi, Najat et. al.
Computer-aided design of non sulphonyl COX-2 inhibitors
score: 2.1899489, Bioorganic & Medicinal Chemistry, 2003, Chakraborti, Asit K.; Thilagavathi, R.
12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
score: 2.1892559, European Journal of Medicinal Chemistry, 2012, Liao, Sheng-Rong et. al.
12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
score: 2.1892559, European Journal of Medicinal Chemistry, 2012, Liao, Sheng-Rong et. al.
12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
score: 2.1892559, European Journal of Medicinal Chemistry, 2012, Liao, Sheng-Rong et. al.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
score: 2.1883717, Bioorganic & Medicinal Chemistry Letters, 2012, He, Hai-Bing et. al.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
score: 2.1883717, Bioorganic & Medicinal Chemistry Letters, 2012, He, Hai-Bing et. al.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
score: 2.1883717, Bioorganic & Medicinal Chemistry Letters, 2012, He, Hai-Bing et. al.
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening
score: 2.1878976, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Peng et. al.
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening
score: 2.1878976, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Peng et. al.
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening
score: 2.1878976, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Peng et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1875095, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.1874936, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.1874936, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Identification of chalcones as potent and selective PDE5A1 inhibitors
score: 2.1874936, Bioorganic & Medicinal Chemistry Letters, 2012, Nam, Ky-Youb; Choi, Nam Song; Han, Cheol Kyu; Ahn, Soon Kil
Combinatorial synthesis and biological evaluation of Library of small-molecule Ser/Thr-protein phosphatase inhibitors
score: 2.187427, Bioorganic & Medicinal Chemistry, 1997, Wipf, Peter et. al.
Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues
score: 2.1869104, Bioorganic & Medicinal Chemistry, 2003, Caballero, Esther et. al.
Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists
score: 2.1866722, Bioorganic & Medicinal Chemistry Letters, 2012, Berezowska, Irena et. al.
Structure–activity relationship study on benzoic acid part of diphenylamine-based retinoids
score: 2.1856774, Bioorganic & Medicinal Chemistry Letters, 2013, Ohta, Kiminori et. al.
CoMFA and docking studies on triazolopyridine oxazole derivatives as p38 MAP kinase inhibitors
score: 2.1855682, European Journal of Medicinal Chemistry, 2008, Shashi Nayana, M. Ravi et. al.
COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates
score: 2.1854795, Bioorganic & Medicinal Chemistry, 2012, Fagan, Vincent et. al.
COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates
score: 2.1854795, Bioorganic & Medicinal Chemistry, 2012, Fagan, Vincent et. al.
COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates
score: 2.1854795, Bioorganic & Medicinal Chemistry, 2012, Fagan, Vincent et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.1853926, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.1853926, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.1853926, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90
score: 2.1838575, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Kenneth H. et. al.
Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives
score: 2.1834071, Bioorganic & Medicinal Chemistry Letters, 2012, Ohnmacht, Stephan A. et. al.
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents
score: 2.1831766, European Journal of Medicinal Chemistry, 2012, Tonk, Rajiv Kumar et. al.
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles
score: 2.1831669, Bioorganic & Medicinal Chemistry, 2006, Yonetoku, Yasuhiro et. al.
Synthesis of highly potent novel anti-tubercular isoniazid analogues with preliminary pharmacokinetic evaluation
score: 2.1824634, Bioorganic & Medicinal Chemistry Letters, 2012, Ramani, Addepalli Venkata et. al.
Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
score: 2.182462, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors
score: 2.1822944, Bioorganic & Medicinal Chemistry, 2006, Amélia Santos, M. et. al.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
score: 2.1817967, Bioorganic & Medicinal Chemistry Letters, 2012, Hsu, John T.-A. et. al.
Docking-based 3D-QSAR study of HIV-1 integrase inhibitors
score: 2.1809192, European Journal of Medicinal Chemistry, 2009, Gupta, Pawan; Roy, Nilanjan; Garg, Prabha
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.1801538, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
score: 2.1789271, Bioorganic & Medicinal Chemistry Letters, 2012, Jiao, XianYun et. al.
Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles
score: 2.1774187, Bioorganic & Medicinal Chemistry, 2012, Fajkusova, Dagmar et. al.
Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles
score: 2.1774187, Bioorganic & Medicinal Chemistry, 2012, Fajkusova, Dagmar et. al.
Hybrid fluorescent conjugates of COX-2 inhibitors: Search for a COX-2 isozyme imaging cancer biomarker
score: 2.1764532, Bioorganic & Medicinal Chemistry Letters, 2013, Bhardwaj, Atul et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.1754596, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.1754596, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
score: 2.1754596, Bioorganic & Medicinal Chemistry, 2012, Urban, Milan et. al.
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives
score: 2.1745399, European Journal of Medicinal Chemistry, 2013, Verones, Valérie et. al.
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives
score: 2.1745399, European Journal of Medicinal Chemistry, 2013, Verones, Valérie et. al.
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells
score: 2.1739462, European Journal of Medicinal Chemistry, 2012, LLanos, Gabriel G. et. al.
Antimycobacterial activity: A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines
score: 2.1738528, Bioorganic & Medicinal Chemistry Letters, 2012, Wei, Ang Chee et. al.
Structure–activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors
score: 2.172509, Bioorganic & Medicinal Chemistry Letters, 2010, Cuny, Gregory D. et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.1724564, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.1724564, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)
score: 2.1724564, Bioorganic & Medicinal Chemistry Letters, 2012, Malwal, Satish R. et. al.
3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues
score: 2.1718034, Bioorganic & Medicinal Chemistry, 2000, Nakagawa, Yoshiaki et. al.
Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners
score: 2.171364, European Journal of Medicinal Chemistry, 2012, Abu-Aisheh, Marwa N. et. al.
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo
score: 2.1711135, European Journal of Medicinal Chemistry, 2012, Ham, Jungyeob et. al.
Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.1709741, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.1709741, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.1709741, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB 1 and CB 2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB 2 receptor agonists
score: 2.1706436, Bioorganic & Medicinal Chemistry, 2005, Huffman, John W. et. al.
[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers
score: 2.1698846, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Min et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines –σ1 receptor ligands with modified benzene-N-distance
score: 2.1688492, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines –σ1 receptor ligands with modified benzene-N-distance
score: 2.1688492, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
Evaluation of and -Aryl-Substitutions and Central Scaffold Modifications on Diphenyl Substituted Alkanes as 5-Lipoxygenase Activating Protein Inhibitors
score: 2.1681838, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.1679041, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.1679041, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.1679041, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors
score: 2.167898, Bioorganic & Medicinal Chemistry Letters, 2012, Jonckers, Tim H.M. et. al.
Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents
score: 2.167072, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hao et. al.
A microwave-assisted, facile, regioselective Friedländer synthesis and antitubercular evaluation of 2,9-diaryl-2,3-dihydrothieno-[3,2- b]quinolines
score: 2.1667277, European Journal of Medicinal Chemistry, 2010, Balamurugan, Kamaraj et. al.
Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2
score: 2.1664305, Bioorganic & Medicinal Chemistry Letters, 2012, Fuchi, Nobuhiro et. al.
Recent developments in the identification of novel oxazolidinone antibacterial agents
score: 2.1655725, Bioorganic & Medicinal Chemistry, 2006, Renslo, Adam R.; Luehr, Gary W.; Gordeev, Mikhail F.
Synthesis and Inhibitory Activity of Novel Tri- and Tetracyclic Quinolines against Topoisomerases
score: 2.1652472, Bioorganic & Medicinal Chemistry, 1998, Sui, Zhihua et. al.
Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors
score: 2.1651355, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Yanyang et. al.
Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents
score: 2.1649809, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hao et. al.
Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents
score: 2.1649809, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hao et. al.
QSAR study for a novel series of ortho disubstituted phenoxy analogues of α 1-adrenoceptor antagonist WB4101
score: 2.1649063, European Journal of Medicinal Chemistry, 2006, Pallavicini, M. et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1643566, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and pharmacological evaluation of substituted naphth[1,2,3- de]isoquinolines (dinapsoline analogues) as D 1 and D 2 dopamine receptor ligands
score: 2.1634294, Bioorganic & Medicinal Chemistry, 2003, Qandil, Amjad M et. al.
Structure aided design of chimeric antibiotics
score: 2.1627336, Bioorganic & Medicinal Chemistry Letters, 2012, Karoli, Tomislav et. al.
Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.1619787, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.1619787, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.1619787, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents
score: 2.1618087, Bioorganic & Medicinal Chemistry Letters, 2012, Venkatraj, Muthusamy et. al.
Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere
score: 2.161767, Bioorganic & Medicinal Chemistry, 2003, Uddin, Md.Jashim; Rao, P.N.Praveen; Knaus, Edward E.
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.1614231, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.1614231, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
Furin inhibitors: Importance of the positive formal charge and beyond
score: 2.1614231, Bioorganic & Medicinal Chemistry, 2012, López-Vallejo, Fabian; Martínez-Mayorga, Karina
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.1604756, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.1604756, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
score: 2.1604756, Bioorganic & Medicinal Chemistry Letters, 2012, Brown, Dearg S. et. al.
SAR and biological evaluation of novel trans-3,4-dimethyl-4-arylpiperidine derivatives as opioid antagonists
score: 2.1599058, Bioorganic & Medicinal Chemistry Letters, 2005, Díaz, Nuria et. al.
Synthesis and structure–activity relationships of metal–ligand complexes that potently inhibit cell migration
score: 2.1598691, Bioorganic & Medicinal Chemistry Letters, 2008, Beshir, Anwar B. et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1597813, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1597813, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
score: 2.1597813, Bioorganic & Medicinal Chemistry Letters, 2012, Hunt, Hazel J. et. al.
Identification ofN-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4–beta1 and alpha4–beta7 receptor antagonists
score: 2.1596395, Bioorganic & Medicinal Chemistry Letters, 2013, Sidduri, Achyutharao et. al.
Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects
score: 2.159366, Bioorganic & Medicinal Chemistry Letters, 2012, Liao, Vivian; Liu, Tao; Codd, Rachel
Synthesis and biological evaluation of acyclic triaryl ( Z)-olefins possessing a 3,5-di- tert-butyl-4-hydroxyphenyl pharmacophore: Dual inhibitors of cyclooxygenases and lipoxygenases
score: 2.1592251, Bioorganic & Medicinal Chemistry, 2006, Moreau, Anne; Praveen Rao, P.N.; Knaus, Edward E.
COX inhibitors Indomethacin and Sulindac derivatives as antiproliferative agents: Synthesis, biological evaluation, and mechanism investigation
score: 2.1586182, European Journal of Medicinal Chemistry, 2012, Chennamaneni, Snigdha; Zhong, Bo; Lama, Rati; Su, Bin
COX inhibitors Indomethacin and Sulindac derivatives as antiproliferative agents: Synthesis, biological evaluation, and mechanism investigation
score: 2.1586182, European Journal of Medicinal Chemistry, 2012, Chennamaneni, Snigdha; Zhong, Bo; Lama, Rati; Su, Bin
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
score: 2.1584622, European Journal of Medicinal Chemistry, 2012, Wijtmans, Maikel et. al.
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
score: 2.1584622, European Journal of Medicinal Chemistry, 2012, Wijtmans, Maikel et. al.
Structurally diverse disaccharide analogs of antifreeze glycoproteins and their ability to inhibit ice recrystallization
score: 2.1574303, Bioorganic & Medicinal Chemistry Letters, 2012, Balcerzak, Anna K. et. al.
Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors
score: 2.1567964, Bioorganic & Medicinal Chemistry Letters, 2004, Tedder, Martina E. et. al.
Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU
score: 2.1561902, European Journal of Medicinal Chemistry, 2012, Min, Jun; Lin, Da; Zhang, Qingye; Zhang, Jibing; Yu, Ziniu
Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU
score: 2.1561902, European Journal of Medicinal Chemistry, 2012, Min, Jun; Lin, Da; Zhang, Qingye; Zhang, Jibing; Yu, Ziniu
Structure–activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents
score: 2.1552977, Bioorganic & Medicinal Chemistry, 2012, Mizuhara, Tsukasa et. al.
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization
score: 2.1552316, Bioorganic & Medicinal Chemistry, 2012, Prakasham, A.P. et. al.
Triarylpyrazoles with basic side chains
score: 2.1544412, Bioorganic & Medicinal Chemistry, 2001, Stauffer, Shaun R et. al.
Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors
score: 2.153565, Bioorganic & Medicinal Chemistry, 2005, Koshio, Hiroyuki et. al.
Discovery of a new class of potent, selective, and orally active prostaglandin D 2 receptor antagonists
score: 2.1535279, Bioorganic & Medicinal Chemistry, 2004, Torisu, Kazuhiko et. al.
Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues
score: 2.1532272, Bioorganic & Medicinal Chemistry, 2006, Bharate, Sandip B. et. al.
Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure–activity relationship
score: 2.1522914, Bioorganic & Medicinal Chemistry, 2002, Matter, Hans et. al.
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
score: 2.1520536, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics
score: 2.1517016, Bioorganic & Medicinal Chemistry Letters, 2012, Tran, Thanh-Dao et. al.
Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics
score: 2.1517016, Bioorganic & Medicinal Chemistry Letters, 2012, Tran, Thanh-Dao et. al.
Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity
score: 2.1500897, Bioorganic & Medicinal Chemistry, 2005, Mojarrad, Javid S. et. al.
Synthesis and Selective Cytotoxic Activity of Novel Hybrid Chalcones against Prostate Cancer Cells
score: 2.1494557, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Design and structure–activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization
score: 2.1486823, Bioorganic & Medicinal Chemistry, 2001, Zega, A et. al.
Cinnamic amides of ( S )-2-(aminomethyl)pyrrolidines are potent H 3 antagonists
score: 2.1483906, Bioorganic & Medicinal Chemistry, 2004, Peschke, Bernd et. al.
Structure-based 3D-QSAR studies on heteroarylpiperazine derivatives as 5-HT 3 receptor antagonists
score: 2.1483685, European Journal of Medicinal Chemistry, 2007, Zhou, Ya-Ju; Zhu, Li-Ping; Tang, Yun; Ye, De-Yong
Synthesis, antimycobacterial and antibacterial activity of ciprofloxacin derivatives containing a N-substituted benzyl moiety
score: 2.1479308, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Shuo et. al.
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin
score: 2.1478284, Bioorganic & Medicinal Chemistry, 1998, Anizon, Fabrice et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.1477554, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.1477554, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II
score: 2.1477554, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Chulho et. al.
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.1469299, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 2.14679, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 2.14679, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 2.14679, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Histone deacetylase inhibitors
score: 2.1466963, European Journal of Medicinal Chemistry, 2005, Monneret, Claude
Tetrabutylammonium fluoride-assisted rapid N 9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ
score: 2.1462184, Bioorganic & Medicinal Chemistry, 2005, Brik, Ashraf; Wu, Chung-Yi; Best, Michael D.; Wong, Chi-Huey
Inhibitory mode of 2-acetoxyphenyl alkyl sulfides against COX-1 and COX-2: QSAR analyses
score: 2.1458903, Bioorganic & Medicinal Chemistry Letters, 2006, Jain, Hemant Kumar; Mourya, V.K.; Agrawal, R.K.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 2.1454268, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 2.1454268, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
Systemic antibacterial activity of novel synthetic cyclic peptides.
score: 2.144389, Antimicrobial agents and chemotherapy, 2005, Dartois, Véronique et. al.
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step
score: 2.1442374, European Journal of Medicinal Chemistry, 2012, Ramunno, Anna et. al.
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition
score: 2.1438529, Bioorganic & Medicinal Chemistry Letters, 2012, Sarkis, Manal et. al.
Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)
score: 2.1436707, Bioorganic & Medicinal Chemistry, 1997, Dutta, A.K et. al.
Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)
score: 2.1436707, Bioorganic & Medicinal Chemistry, 1997, Dutta, A.K et. al.
Synthesis, receptor binding, and activation studies of N(1)-alkyl- l-histidine containing thyrotropin-releasing hormone (TRH) analogues
score: 2.1431694, Bioorganic & Medicinal Chemistry, 2006, Kaur, Navneet et. al.
Is chemical synthetic accessibility computationally predictable for drug and lead-like molecules? A comparative assessment between medicinal and computational chemists
score: 2.1429684, European Journal of Medicinal Chemistry, 2012, Bonnet, Pascal
Synthesis and biological activities of polyquinoline derivatives: New Bcl-2 family protein modulators
score: 2.1426848, European Journal of Medicinal Chemistry, 2012, Saugues, Emmanuelle et. al.
Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors
score: 2.1425738, Bioorganic & Medicinal Chemistry Letters, 2012, Jonckers, Tim H.M. et. al.
Development of α-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease
score: 2.1425271, Bioorganic & Medicinal Chemistry, 2005, Choe, Youngchool et. al.
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists
score: 2.1420936, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Structure requirements for anaerobe processing of azo compounds: Implications for prodrug design
score: 2.1417014, Bioorganic & Medicinal Chemistry Letters, 2012, Gavin, Jason et. al.
Toward the control of Leptosphaeria maculans: Design, syntheses, biological activity, and metabolism of potential detoxification inhibitors of the crucifer phytoalexin brassinin
score: 2.1409349, Bioorganic & Medicinal Chemistry, 2006, Pedras, M. Soledade C.; Jha, Mukund
Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: Dual inhibitors of EGFR and Src protein tyrosine kinases
score: 2.1407858, European Journal of Medicinal Chemistry, 2012, Lin, Jinsheng et. al.
Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents
score: 2.1402529, Bioorganic & Medicinal Chemistry, 2006, Sunduru, Naresh et. al.
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors
score: 2.140051, Bioorganic & Medicinal Chemistry, 2012, Alipour, Masoumeh et. al.
Synthesis of new sulfonamides as lipoxygenase inhibitors
score: 2.1400386, Bioorganic & Medicinal Chemistry, 2012, Mustafa, Ghulam et. al.
Design, synthesis, and structure–activity-relationship of phenyl imidazoles as potent Smoothened antagonists
score: 2.1400179, Bioorganic & Medicinal Chemistry Letters, 2012, Cheng, Dai et. al.
Design, synthesis, and structure–activity-relationship of phenyl imidazoles as potent Smoothened antagonists
score: 2.1400179, Bioorganic & Medicinal Chemistry Letters, 2012, Cheng, Dai et. al.
Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins
score: 2.1396619, Bioorganic & Medicinal Chemistry, 1998, Keenan, Terence et. al.
C 2-Symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases
score: 2.1395393, Bioorganic & Medicinal Chemistry, 1996, Qian, Xinhua et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1394266, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1394266, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and fungicidal activity of novel pimprinine analogues
score: 2.1394266, European Journal of Medicinal Chemistry, 2012, Zhang, Ming-Zhi et. al.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 2.1385025, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
score: 2.1384678, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Hermogenes N. et. al.
C-Glucosylated malonitrile as a key intermediate towards carbohydrate-based glycogen phosphorylase inhibitors
score: 2.1383706, Bioorganic & Medicinal Chemistry, 2012, Feuillastre, Sophie et. al.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives
score: 2.1382152, Bioorganic & Medicinal Chemistry, 2012, Hirose, Masaaki et. al.
Theoretical study of structure, p K a, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives
score: 2.1380492, Bioorganic & Medicinal Chemistry, 2006, Remko, Milan; Swart, Marcel; Bickelhaupt, F. Matthias
Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors
score: 2.1380337, Bioorganic & Medicinal Chemistry, 2005, Grunewald, Gary L. et. al.
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies
score: 2.1379144, Bioorganic & Medicinal Chemistry, 2013, Catarzi, Daniela et. al.
In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones
score: 2.1375284, Bioorganic & Medicinal Chemistry, 2004, Aguirre, Gabriela et. al.
QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR
score: 2.1370731, Bioorganic & Medicinal Chemistry, 2005, Zhu, Weiliang et. al.
Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety
score: 2.1360845, Bioorganic & Medicinal Chemistry Letters, 2012, Arai, Tadamasa et. al.
Synthesis and biological activity assays of some new N1-(flavon-7-yl) amidrazone derivatives and related congeners
score: 2.1358203, European Journal of Medicinal Chemistry, 2012, Abu-Aisheh, Marwa N. et. al.
Synthesis and Cytotoxicity of Lupane-Type Triterpenoid Glyceryl Esters
score: 2.1341882, Bioorganic & Medicinal Chemistry Letters, 2012, Thibeault, Dominic et. al.
New piperazinyl polyazacyclophane scaffolds, libraries and biological activities
score: 2.1337216, Bioorganic & Medicinal Chemistry Letters, 1998, An, Haoyun; Haly, Becky D.; Cook, P.Dan
5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents
score: 2.1331636, Bioorganic & Medicinal Chemistry, 2005, Ottanà, Rosaria et. al.
Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides
score: 2.1328549, Bioorganic & Medicinal Chemistry, 2004, Mitsch, Andreas et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 2.1328209, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 2.1328209, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 2.1328209, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents
score: 2.1327458, Bioorganic & Medicinal Chemistry Letters, 2012, Bandgar, Babasaheb P. et. al.
Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors
score: 2.1327297, European Journal of Medicinal Chemistry, 2004, Martić, Miljen et. al.
Three-dimensional quantitative structure–activity relationship studies on novel series of benzotriazine based compounds acting as Src inhibitors using CoMFA and CoMSIA
score: 2.1324816, Bioorganic & Medicinal Chemistry, 2008, Gueto, Carlos et. al.
Design and synthesis of broad-Based mono- and bi- cyclic inhibitors of FIV and HIV proteases
score: 2.132425, Bioorganic & Medicinal Chemistry, 2003, Mak, Chi Ching et. al.
Identification of pyrimidine derivatives as hSMG-1 inhibitors
score: 2.1323158, Bioorganic & Medicinal Chemistry Letters, 2012, Gopalsamy, Ariamala et. al.
Identification of pyrimidine derivatives as hSMG-1 inhibitors
score: 2.1323158, Bioorganic & Medicinal Chemistry Letters, 2012, Gopalsamy, Ariamala et. al.
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists
score: 2.1319668, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists
score: 2.1319668, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Synthesis, structure–activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors
score: 2.1311895, European Journal of Medicinal Chemistry, 2012, Ma, Xiao-Dong et. al.
Synthesis, structure–activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors
score: 2.1311895, European Journal of Medicinal Chemistry, 2012, Ma, Xiao-Dong et. al.
Synthesis, structure–activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors
score: 2.1311895, European Journal of Medicinal Chemistry, 2012, Ma, Xiao-Dong et. al.
Long-acting peptidomimetics based DPP-IV inhibitors
score: 2.1311805, Bioorganic & Medicinal Chemistry Letters, 2012, Jadav, Pradip et. al.
Long-acting peptidomimetics based DPP-IV inhibitors
score: 2.1311805, Bioorganic & Medicinal Chemistry Letters, 2012, Jadav, Pradip et. al.
GABA receptor antagonists and insecticides: common structural features of 4-alkyl-1-phenylpyrazoles and 4-alkyl-1-phenyltrioxabicyclooctanes
score: 2.130933, Bioorganic & Medicinal Chemistry, 2004, Sammelson, Robert E et. al.
Benzofuranones as potential antinociceptive agents: Structure–activity relationships
score: 2.1307705, European Journal of Medicinal Chemistry, 2012, Gonçalves, Cleiton José et. al.
Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties
score: 2.1297591, European Journal of Medicinal Chemistry, 2002, Balsamo, Aldo et. al.
QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase
score: 2.1283263, Bioorganic & Medicinal Chemistry Letters, 2006, Jamloki, Ashutosh et. al.
Aryl Cyclopentadienyl Tricarbonyl Rhenium Complexes: Novel Ligands for the Estrogen Receptor with Potential Use as Estrogen Radiopharmaceuticals
score: 2.1281433, Bioorganic & Medicinal Chemistry, 2002, Mull, Eric S et. al.
Antibacterial activities of Groebke–Blackburn–Bienaymé-derived imidazo[1,2-a]pyridin-3-amines
score: 2.1274488, Bioorganic & Medicinal Chemistry, 2012, Shukla, Nikunj M. et. al.
Design, synthesis, and anti-integrase activity of catechol–DKA hybrids
score: 2.126661, Bioorganic & Medicinal Chemistry, 2006, Maurin, Cédric et. al.
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity
score: 2.1260434, Bioorganic & Medicinal Chemistry, 2013, Kwon, Yongseok et. al.
Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking
score: 2.1257892, Bioorganic & Medicinal Chemistry Letters, 2012, Fu, Jing et. al.
Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking
score: 2.1257892, Bioorganic & Medicinal Chemistry Letters, 2012, Fu, Jing et. al.
3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB 1 cannabinoid receptor
score: 2.1250191, Bioorganic & Medicinal Chemistry, 2003, Huffman, John W et. al.
Classification models for CYP450 3A4 inhibitors and non-inhibitors
score: 2.1244992, European Journal of Medicinal Chemistry, 2009, Choi, Inhee et. al.
Design, Prins-cyclization reaction promoting diastereoselective synthesis of 10 new tetrahydropyran derivatives and in vivo antinociceptive evaluations
score: 2.1240316, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Design, synthesis, and biological evaluation of ( E)- and ( Z)-styryl-2-acetoxyphenyl sulfides and sulfones as cyclooxygenase-2 inhibitors
score: 2.1238528, Bioorganic & Medicinal Chemistry, 2005, Reddy, M.V. Ramana et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase
score: 2.1236278, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase
score: 2.1236278, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase
score: 2.1236278, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
3D-QSAR Analysis of 2,4,5- and 2,3,4,5-substituted imidazoles as potent and nontoxic modulators of P-glycoprotein mediated MDR
score: 2.1235783, Bioorganic & Medicinal Chemistry, 2001, Kim, Ki H
Structure–activity relationships of a series of tariquidar analogs as multidrug resistance modulators
score: 2.1222638, Bioorganic & Medicinal Chemistry, 2006, Globisch, Christoph; Pajeva, Ilza K.; Wiese, Michael
Design, synthesis, and biological evaluation of substituted 3-alkylthio-4,5-diaryl-4 H-1,2,4-triazoles as selective COX-2 inhibitors
score: 2.1210272, Bioorganic & Medicinal Chemistry, 2006, Navidpour, Latifeh et. al.
Coumarin-trioxane hybrids: synthesis and evaluation as a new class of antimalarial scaffolds
score: 2.1208344, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells
score: 2.1207501, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells
score: 2.1207501, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells
score: 2.1207501, Bioorganic & Medicinal Chemistry Letters, 2012, Nagaraju, M. et. al.
Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors
score: 2.1206237, Bioorganic & Medicinal Chemistry, 2006, Khanna, Smriti et. al.
Tetraketones: A new class of tyrosinase inhibitors
score: 2.1205548, Bioorganic & Medicinal Chemistry, 2006, Khan, Khalid Mohammed et. al.
Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists
score: 2.119623, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Pyrrolo[2,1- d][1,2,3,5]tetrazine-4(3h)-ones, a new class of azolotetrazines with potent antitumor activity
score: 2.1195852, Bioorganic & Medicinal Chemistry, 2003, Diana, Patrizia et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines – σ1 receptor ligands with modified benzene-N-distance
score: 2.1195557, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
CoMFA and molecular docking studies of benzoxazoles and benzothiazoles as CYP450 1A1 inhibitors
score: 2.1193953, European Journal of Medicinal Chemistry, 2010, Pan, Jie et. al.
Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors
score: 2.1185182, Bioorganic & Medicinal Chemistry Letters, 2013, Yeung, Kap-Sun et. al.
3D-QSAR Study on Dihydro-1,3,5-triazines and Their Spiro Derivatives as DHFR Inhibitors by Comparative Molecular Field Analysis (CoMFA)
score: 2.1174951, Bioorganic & Medicinal Chemistry Letters, 2012, Ma, Xiang; Xiang, Guangya; Yap, Chun-Wei; Chui, Wai-Keung
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.1168755, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.1168755, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.1168755, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives
score: 2.1164371, Bioorganic & Medicinal Chemistry, 2005, Imamura, Shinichi et. al.
Derivatives of 8-hydroxyquinoline – antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.1155147, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Synthesis and biological evaluation of 2,7-Dihydro-3 H-dibenzo[ de, h]cinnoline-3,7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line
score: 2.1153701, Bioorganic & Medicinal Chemistry, 2003, Stefańska, Barbara et. al.
Design and synthesis of potent, isoxazole-containing renin inhibitors
score: 2.1148571, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier, Pierre-André et. al.
Design and synthesis of potent, isoxazole-containing renin inhibitors
score: 2.1148571, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier, Pierre-André et. al.
Synthesis and evaluation of antitubercular activity of imidazo[2,1- b][1,3,4]thiadiazole derivatives
score: 2.1146284, Bioorganic & Medicinal Chemistry, 2006, Kolavi, Gundurao et. al.
A synthetic route to a novel type of conformationally constrained N-aryloxazolidinones
score: 2.1143364, Bioorganic & Medicinal Chemistry Letters, 2005, Griera, Rosa et. al.
A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation
score: 2.1142197, Bioorganic & Medicinal Chemistry Letters, 2012, Graham, Thomas H. et. al.
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
score: 2.1142099, Bioorganic & Medicinal Chemistry, 2012, Peng, Da-Yong et. al.
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
score: 2.1142099, Bioorganic & Medicinal Chemistry, 2012, Peng, Da-Yong et. al.
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
score: 2.1142099, Bioorganic & Medicinal Chemistry, 2012, Peng, Da-Yong et. al.
Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: Synthesis and toxicity for drug-resistant tumor cells
score: 2.1141548, Bioorganic & Medicinal Chemistry, 2006, Ol’shevskaya, Valentina A. et. al.
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
score: 2.1136027, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
score: 2.1136027, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase
score: 2.1136027, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression
score: 2.1134258, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Jiho et. al.
Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression
score: 2.1134258, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Jiho et. al.
Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression
score: 2.1134258, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Jiho et. al.
Novel Potent 5-HT 3 Receptor Ligands Based on the Pyrrolidone Structure: Synthesis, Biological Evaluation, and Computational Rationalization of the Ligand–Receptor Interaction Modalities
score: 2.113129, Bioorganic & Medicinal Chemistry, 2002, Cappelli, Andrea et. al.
Synthesis and protein kinase C inhibitory activities of balanol analogues with modification of 4-hydroxybenzamido moiety
score: 2.1128213, Bioorganic & Medicinal Chemistry, 1997, Hu, Hong et. al.
8,9-Dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,- de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms
score: 2.1119504, Bioorganic & Medicinal Chemistry, 2004, Grubbs, Russell A et. al.
Synthesis and cytotoxic evaluation of certain 4-anilino-2-phenylquinoline derivatives
score: 2.1119355, European Journal of Medicinal Chemistry, 2005, Zhao, Yue-Ling et. al.
Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor
score: 2.1119146, Bioorganic & Medicinal Chemistry Letters, 2004, Tan, Christopher et. al.
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
score: 2.1118643, Bioorganic & Medicinal Chemistry Letters, 2012, Balboni, Gianfranco et. al.
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
score: 2.1118643, Bioorganic & Medicinal Chemistry Letters, 2012, Balboni, Gianfranco et. al.
C-6 Aryl Substituted 4-Quinolone-3-carboxylic Acids as Inhibitors of Hepatitis C Virus
score: 2.1117577, Bioorganic & Medicinal Chemistry, 2012, Chen, Yue-Lei et. al.
C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus
score: 2.1117577, Bioorganic & Medicinal Chemistry, 2012, Chen, Yue-Lei et. al.
C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus
score: 2.1117577, Bioorganic & Medicinal Chemistry, 2012, Chen, Yue-Lei et. al.
Recent results in protein kinase inhibition for tropical diseases
score: 2.1116432, Bioorganic & Medicinal Chemistry Letters, 2012, Rotella, David P.
Recent results in protein kinase inhibition for tropical diseases
score: 2.1116432, Bioorganic & Medicinal Chemistry Letters, 2012, Rotella, David P.
Recent results in protein kinase inhibition for tropical diseases
score: 2.1116432, Bioorganic & Medicinal Chemistry Letters, 2012, Rotella, David P.
3-(N-Arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2)
score: 2.110579, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Soo Hyuk et. al.
Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine
score: 2.1095632, Bioorganic & Medicinal Chemistry, 2006, Zhang, Shijun et. al.
Non-thiol farnesyltransferase inhibitors: n-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides
score: 2.1086586, Bioorganic & Medicinal Chemistry, 2003, Kettler, Katja et. al.
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2
score: 2.1080257, Bioorganic & Medicinal Chemistry Letters, 2012, Sasmal, Sanjita et. al.
Long-acting Peptidomimetics based DPP-IV Inhibitors
score: 2.1067045, Bioorganic & Medicinal Chemistry Letters, 2012, Jadav, Pradip et. al.
3D-QSAR analysis of human immunodeficiency virus entry-1 inhibitors by CoMFA and CoMSIA
score: 2.1063486, European Journal of Medicinal Chemistry, 2010, Pirhadi, Somayeh; Ghasemi, Jahan B.
Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase
score: 2.1062017, Bioorganic & Medicinal Chemistry, 2006, Charvat, Trevor T. et. al.
3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists
score: 2.1056244, Bioorganic & Medicinal Chemistry Letters, 2007, Zhang, Tao et. al.
Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella.
score: 2.105592, Antimicrobial agents and chemotherapy, 2012, Schaeffer, Marie et. al.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes
score: 2.1048989, Bioorganic & Medicinal Chemistry Letters, 2012, McCoull, William et. al.
A novel series ofN-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists
score: 2.104757, Bioorganic & Medicinal Chemistry Letters, 2013, Subasinghe, Nalin L. et. al.
Discovery of a novel series of 4-quinolone JNK inhibitors
score: 2.104713, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Discovery of a novel series of 4-quinolone JNK inhibitors
score: 2.104713, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Discovery of a novel series of 4-quinolone JNK inhibitors
score: 2.104713, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Tricyclic pharmacophore-based molecules as novel integrin α vβ 3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting α vβ 3/α IIbβ 3 dual antagonistic activity
score: 2.104346, Bioorganic & Medicinal Chemistry, 2006, Kubota, Dai et. al.
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
score: 2.1042564, Bioorganic & Medicinal Chemistry Letters, 2012, Balboni, Gianfranco et. al.
Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Aβ 25–35 in PC12 cells
score: 2.1042273, Bioorganic & Medicinal Chemistry Letters, 2009, Lee, Sang-Hoon et. al.
Synthesis, characterization and structure optimization of a series of thiazolidinone derivatives as Entamoeba histolytica inhibitors
score: 2.1042082, European Journal of Medicinal Chemistry, 2012, Mushtaque, Md.; Avecilla, Fernando; Azam, Amir
Synthesis and Biological Evaluation of New Piplartine Analogues as Potent Aldose Reductase Inhibitors (ARIs)
score: 2.1036769, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Contribution to Investigation of Antimicrobial Activity of Styrylquinolines
score: 2.1026244, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Synthesis and biological evaluation of 2-thiopyrimidine derivatives
score: 2.102409, Bioorganic & Medicinal Chemistry, 2005, Sondhi, Sham M. et. al.
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
score: 2.1016817, Bioorganic & Medicinal Chemistry Letters, 2012, Youngsaye, Willmen et. al.
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
score: 2.1016817, Bioorganic & Medicinal Chemistry Letters, 2012, Youngsaye, Willmen et. al.
Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5′-sulfonamide moiety of a phenyl ring
score: 2.1009597, Bioorganic & Medicinal Chemistry, 2001, Kim, Dae-Kee et. al.
Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors
score: 2.1008763, Bioorganic & Medicinal Chemistry, 2006, Mannino, Claudia et. al.
Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides
score: 2.1005189, Bioorganic & Medicinal Chemistry, 2003, Larsson, Andreas et. al.
A novel series of pyrazolylpiperidine N-type calcium channel blockers
score: 2.1002906, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
A novel series of pyrazolylpiperidine N-type calcium channel blockers
score: 2.1002906, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
A novel series of pyrazolylpiperidine N-type calcium channel blockers
score: 2.1002906, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
score: 2.1001974, Antimicrobial agents and chemotherapy, 2011, Mills, Scott D et. al.
Pharmacophore identification of c-Myc inhibitor 10074-G5
score: 2.1000488, Bioorganic & Medicinal Chemistry Letters, 2013, Yap, Jeremy L. et. al.
2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors
score: 2.1000292, Bioorganic & Medicinal Chemistry Letters, 2012, Hua, Zihao et. al.
Indole and benzimidazole derivatives as steroid 5α-reductase inhibitors in the rat prostate
score: 2.0999117, Bioorganic & Medicinal Chemistry, 1998, Takami, Hitoshi et. al.
3D-QSAR CoMFA and CoMSIA on protein tyrosine phosphatase 1B inhibitors
score: 2.0996768, Bioorganic & Medicinal Chemistry, 2002, Murthy, V.Sreenivasa; Kulkarni, Vithal M
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 2.0996326, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0994603, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0994603, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0994603, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase
score: 2.0993737, Bioorganic & Medicinal Chemistry, 2003, Pez, Didier et. al.
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
score: 2.0986613, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
score: 2.0986613, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
Chemotherapy of leishmaniasis. Part XI: Synthesis and bioevaluation of novel isoxazole containing heteroretinoid and its amide derivatives
score: 2.0981975, Bioorganic & Medicinal Chemistry Letters, 2012, Suryawanshi, S.N. et. al.
Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives
score: 2.0980283, Bioorganic & Medicinal Chemistry Letters, 2012, Matsumoto, Kohji et. al.
An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
score: 2.09765, Bioorganic & Medicinal Chemistry, 2012, Verbanac, Donatella et. al.
An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
score: 2.09765, Bioorganic & Medicinal Chemistry, 2012, Verbanac, Donatella et. al.
Derivatives of 8-hydroxyquinoline—antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.0973415, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Derivatives of 8-hydroxyquinoline—antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.0973415, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Derivatives of 8-hydroxyquinoline—antibacterial agents that target intra- and extracellular Gram-negative pathogens
score: 2.0973415, Bioorganic & Medicinal Chemistry Letters, 2012, Enquist, Per-Anders et. al.
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1
score: 2.097217, Bioorganic & Medicinal Chemistry Letters, 2012, Gemma, Sandra et. al.
Synthesis and antimuscarinic activity of a Series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents
score: 2.0968381, Bioorganic & Medicinal Chemistry, 1999, Miyachi, Hiroyuki et. al.
New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells
score: 2.0967908, European Journal of Medicinal Chemistry, 2012, Ottanà, Rosaria et. al.
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
score: 2.0958417, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
score: 2.0958417, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
score: 2.0958417, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives
score: 2.0952832, European Journal of Medicinal Chemistry, 2012, Awadallah, Fadi M.; El-Eraky, Wafaa I.; Saleh, Dalia O.
Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives
score: 2.0952832, European Journal of Medicinal Chemistry, 2012, Awadallah, Fadi M.; El-Eraky, Wafaa I.; Saleh, Dalia O.
Anti-inflammatory profile of some synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure
score: 2.095267, Bioorganic & Medicinal Chemistry, 2006, Amr, Abdel-Galil E.; Abdulla, Mohamed M.
Functionalized amido ketones: new anticonvulsant agents
score: 2.0952561, Bioorganic & Medicinal Chemistry, 2003, Béguin, Cécile et. al.
Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABA B receptor affinities
score: 2.0944773, Bioorganic & Medicinal Chemistry Letters, 1998, Carruthers, Nicholas I. et. al.
Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole analogues of duocarmycin B2
score: 2.0942719, Bioorganic & Medicinal Chemistry, 1996, Nagamura, Satoru et. al.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 2.0940914, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group
score: 2.0938996, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Guanglin et. al.
Carbonic anhydrase inhibitors
score: 2.0935175, Bioorganic & Medicinal Chemistry Letters, 2010, Supuran, Claudiu T.
Development of bestatin-based activity-based probes for metallo-aminopeptidases
score: 2.092986, Bioorganic & Medicinal Chemistry Letters, 2008, Harbut, Michael B. et. al.
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
score: 2.0926567, Bioorganic & Medicinal Chemistry, 2012, Barzen, Sebastian et. al.
Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
score: 2.0920298, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Li-Jun et. al.
Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation
score: 2.0918491, Bioorganic & Medicinal Chemistry, 2012, Yan, Jin-Wu et. al.
Synthesis and antibacterial activity against Clostridium difficile of novel demethylvancomycin derivatives
score: 2.0917324, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Si-Ji; Yang, Qing; Xu, Liang; Chang, Jun; Sun, Xun
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0912441, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists
score: 2.0904366, Bioorganic & Medicinal Chemistry, 2012, Hanson, Robert N. et. al.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 2.089574, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors
score: 2.0892872, Bioorganic & Medicinal Chemistry, 2003, Kim, Su Yeon; Lee, Jeewoo
Design, synthesis, and evaluation of novel galloyl pyrrolidine derivatives as potential anti-tumor agents
score: 2.0885759, Bioorganic & Medicinal Chemistry, 2006, Li, Xun; Li, Yalin; Xu, Wenfang
Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3- b]pyridine derivatives
score: 2.0884687, Bioorganic & Medicinal Chemistry, 2006, Rolim Bernardino, Alice Maria et. al.
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
score: 2.0876381, Bioorganic & Medicinal Chemistry Letters, 2012, McAllister, Laura A. et. al.
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
score: 2.0876381, Bioorganic & Medicinal Chemistry Letters, 2012, McAllister, Laura A. et. al.
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
score: 2.0876381, Bioorganic & Medicinal Chemistry Letters, 2012, McAllister, Laura A. et. al.
Structural studies of [2′,6′-dimethyl- l-tyrosine 1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond
score: 2.0867902, Bioorganic & Medicinal Chemistry, 2003, Okada, Yoshio et. al.
The development of 3D-QSAR study and recursive partitioning of heterocyclic quinone derivatives with antifungal activity
score: 2.0863989, Bioorganic & Medicinal Chemistry, 2006, Choi, Su-Young et. al.
In vitro evaluation of the anti-estrogenic activity of hydroxyl substituted diphenylnaphthyl alkene ligands for the estrogen receptor
score: 2.0862984, Bioorganic & Medicinal Chemistry, 2005, Schmidt, Jonathan M. et. al.
2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A 2A receptor
score: 2.0862643, Bioorganic & Medicinal Chemistry, 2003, van Tilburg, Erica W et. al.
N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor
score: 2.0861708, Bioorganic & Medicinal Chemistry Letters, 2012, Vallin, Karl S.A. et. al.
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer’s disease
score: 2.0853459, Bioorganic & Medicinal Chemistry, 2012, Roy, Kuldeep K. et. al.
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer’s disease
score: 2.0853459, Bioorganic & Medicinal Chemistry, 2012, Roy, Kuldeep K. et. al.
A combined approach of docking and 3D QSAR study of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 2.0834107, Bioorganic & Medicinal Chemistry, 2006, Ashek, Ali; Cho, Seung Joo
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition
score: 2.0828195, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles
score: 2.0825521, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yuusuke et. al.
Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis
score: 2.081599, Bioorganic & Medicinal Chemistry, 2006, Poulsen, Sally-Ann; Bornaghi, Laurent F.
3D-QSAR of N-myristoyltransferase inhibiting antifungal agents by CoMFA and CoMSIA methods
score: 2.0811661, Bioorganic & Medicinal Chemistry, 2003, Purushottamachar, P.; Kulkarni, Vithal M.
Synthesis, biological evaluation and structure–activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
score: 2.0811621, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Li-Jun et. al.
Synthesis, biological evaluation and structure–activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
score: 2.0811621, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Li-Jun et. al.
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
score: 2.0811344, Bioorganic & Medicinal Chemistry, 2012, Mao, Weiwei et. al.
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
score: 2.0811344, Bioorganic & Medicinal Chemistry, 2012, Mao, Weiwei et. al.
3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists
score: 2.0811232, Bioorganic & Medicinal Chemistry, 2004, Mitchell, Daniel D et. al.
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics
score: 2.08112, European Journal of Medicinal Chemistry, 2012, Sarkar, Aurijit; Anderson, Kelcey C.; Kellogg, Glen E.
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics
score: 2.08112, European Journal of Medicinal Chemistry, 2012, Sarkar, Aurijit; Anderson, Kelcey C.; Kellogg, Glen E.
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics
score: 2.08112, European Journal of Medicinal Chemistry, 2012, Sarkar, Aurijit; Anderson, Kelcey C.; Kellogg, Glen E.
Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties
score: 2.0810451, Bioorganic & Medicinal Chemistry, 2012, Rakesh, et. al.
Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones
score: 2.0808374, Bioorganic & Medicinal Chemistry Letters, 2012, Ochiai, Koji et. al.
Structure requirements for anaerobe processing of azo compounds: Implications for prodrug design
score: 2.0802787, Bioorganic & Medicinal Chemistry Letters, 2012, Gavin, Jason et. al.
Structure requirements for anaerobe processing of azo compounds: Implications for prodrug design
score: 2.0802787, Bioorganic & Medicinal Chemistry Letters, 2012, Gavin, Jason et. al.
Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues
score: 2.0798219, Bioorganic & Medicinal Chemistry, 2013, Bhabak, Krishna P. et. al.
C(8)-Substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands
score: 2.0796281, Bioorganic & Medicinal Chemistry, 2004, Goo Kim, Myoung et. al.
Design of novel nicotinic ligands through 3D database searching
score: 2.0792665, Bioorganic & Medicinal Chemistry, 2005, Guandalini, Luca et. al.
Structural analogues of 5-OMe-BPAT: synthesis and interactions with dopamine D 2, D 3, and serotonin 5-HT 1A receptors
score: 2.0789897, Bioorganic & Medicinal Chemistry, 1999, Homan, Evert J. et. al.
Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity
score: 2.0783777, Bioorganic & Medicinal Chemistry, 2003, Clarkson, Cailean et. al.
3D-QSAR studies of indole derivatives as phosphodiesterase IV inhibitors
score: 2.0781624, European Journal of Medicinal Chemistry, 2003, Chakraborti, Asit K et. al.
Pyrazole-based arylalkyne Cathepsin S inhibitors. Part III: Modification of P4 region
score: 2.0781279, Bioorganic & Medicinal Chemistry Letters, 2013, Wiener, John J.M. et. al.
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
score: 2.0780141, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
score: 2.0780141, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors
score: 2.0780141, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity
score: 2.0777275, Bioorganic & Medicinal Chemistry Letters, 2012, Jakopović, Ivana Palej et. al.
Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity
score: 2.0777275, Bioorganic & Medicinal Chemistry Letters, 2012, Jakopović, Ivana Palej et. al.
Biotin-phenyldiazomethane conjugates as labeling reagents at phosphate in mono and polynucleotides
score: 2.0776134, Bioorganic & Medicinal Chemistry, 2005, Bourget, Cécile et. al.
Design and synthesis of 2-acetamidomethyl derivatives of isofagomine as potential inhibitors of human lysosomal β-hexosaminidases
score: 2.0772661, Bioorganic & Medicinal Chemistry, 2004, van den Berg, Richard J.B.H.N et. al.
Synthesis and antitumor activity of duocarmycin derivatives: modification at C-8 position of A-ring pyrrole compounds bearing the simplified DNA-binding groups
score: 2.0767512, Bioorganic & Medicinal Chemistry, 2000, Amishiro, Nobuyoshi et. al.
Structure–activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter
score: 2.0760973, Bioorganic & Medicinal Chemistry, 2006, Boos, Terrence L. et. al.
Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR
score: 2.0760019, Bioorganic & Medicinal Chemistry Letters, 2010, Mitchell, Charlotte J. et. al.
TAK-599, a novel N-Phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties
score: 2.0753744, Bioorganic & Medicinal Chemistry, 2003, Ishikawa, Tomoyasu et. al.
Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors
score: 2.074789, Bioorganic & Medicinal Chemistry Letters, 2012, Sun, Lian-Qi et. al.
Synthesis and glycosidase inhibitory activities of 2-(aminoalkyl)pyrrolidine-3,4-diol derivatives
score: 2.0747539, Bioorganic & Medicinal Chemistry, 2003, Carmona, Ana T et. al.
Identification and characterization of new inhibitors of the Escherichia coli MurA enzyme.
score: 2.0743389, Antimicrobial agents and chemotherapy, 2001, Baum, E Z et. al.
Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor
score: 2.0742457, Bioorganic & Medicinal Chemistry, 2012, Wang, Fang et. al.
Synthesis, characterization and antibacterial activities of some new ferrocene-containing penems
score: 2.0734394, European Journal of Medicinal Chemistry, 2010, Long, Bohua; He, Chunlian; Yang, Yingbin; Xiang, Jiannan
Development and assessment of a 3D pharmacophore for ligand recognition of BDZR/GABA A receptors initiating the anxiolytic response
score: 2.0733608, Bioorganic & Medicinal Chemistry, 2000, Harris, Danni L; Loew, Gilda
Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application
score: 2.0729243, Bioorganic & Medicinal Chemistry Letters, 2013, Kesteleyn, Bart et. al.
Synthesis and Antimalarial Activity of Calothrixins A and B, and their N-Alkyl Derivatives
score: 2.0724927, Bioorganic & Medicinal Chemistry Letters, 2012, Matsumoto, Kohji et. al.
Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives
score: 2.0723856, Bioorganic & Medicinal Chemistry Letters, 2012, Matsumoto, Kohji et. al.
Design, Prins–Cyclization Reaction Promoting Diastereoselective Synthesis of Ten New Tetrahydropyran Derivatives and in vivo Antinociceptive Evaluations
score: 2.072277, European Journal of Medicinal Chemistry, 2012, Capim, Saulo L. et. al.
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
score: 2.0715312, Bioorganic & Medicinal Chemistry, 2012, Yoshida, Tomohiro et. al.
Synthesis and anticancer activity of a series of norcantharidin analogues
score: 2.0712728, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety
score: 2.0712482, European Journal of Medicinal Chemistry, 2012, Metwally, M.A.; Gouda, M.A.; Harmal, Ammar N.; Khalil, A.M.
Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety
score: 2.0712482, European Journal of Medicinal Chemistry, 2012, Metwally, M.A.; Gouda, M.A.; Harmal, Ammar N.; Khalil, A.M.
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
score: 2.0707587, Bioorganic & Medicinal Chemistry, 2006, Dong, Yuxiang et. al.
Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5 H-benzo[5,6]-cyclohepta[1,2- b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase
score: 2.0698018, Bioorganic & Medicinal Chemistry, 1999, Afonso, Adriano et. al.
Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers
score: 2.0694228, Bioorganic & Medicinal Chemistry Letters, 2002, Olsen, J.A et. al.
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings
score: 2.0693824, Bioorganic & Medicinal Chemistry, 2006, Deng, Bo-Liang et. al.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
score: 2.0687702, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel J. et. al.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
score: 2.0687702, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel J. et. al.
Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity
score: 2.0681991, Nature chemical biology, 2010, Bruning, John B. et. al.
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents
score: 2.0681272, European Journal of Medicinal Chemistry, 2012, Tonk, Rajiv Kumar et. al.
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
score: 2.0680923, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
score: 2.0675494, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
score: 2.0675494, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
Boronic acids as inhibitors of steroid sulfatase
score: 2.067072, Bioorganic & Medicinal Chemistry, 2006, Ahmed, Vanessa et. al.
Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2
score: 2.0669844, Bioorganic & Medicinal Chemistry Letters, 2012, Tynebor, Robert M. et. al.
In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers
score: 2.0669742, Bioorganic & Medicinal Chemistry, 2003, Vargas M, Leonor Y et. al.
Synthesis, biological evaluation, and structural studies on N1 and C5 substituted cycloalkyl analogues of the pyrazole class of CB1 and CB2 ligands
score: 2.0666896, Bioorganic & Medicinal Chemistry, 2004, Krishnamurthy, Mathangi; Li, Wei; Moore, Bob M
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases
score: 2.0663639, Bioorganic & Medicinal Chemistry, 2013, Lai, Huiguo et. al.
Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems—I. 2-alkoxymethyl derivatives
score: 2.0663057, Bioorganic & Medicinal Chemistry, 1997, Azami, Hidenori et. al.
Synthesis and structure–activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT)
score: 2.0662088, Bioorganic & Medicinal Chemistry Letters, 2004, Ohnuma, Satoshi et. al.
Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone
score: 2.0661025, Bioorganic & Medicinal Chemistry, 2005, Cao, Shugeng et. al.
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
score: 2.0659933, Bioorganic & Medicinal Chemistry, 2012, B-Rao, Chandrika et. al.
Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty
score: 2.065804, Bioorganic & Medicinal Chemistry Letters, 2012, Basarab, Gregory S. et. al.
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies
score: 2.0656084, European Journal of Medicinal Chemistry, 2012, Ceras, Javier et. al.
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies
score: 2.0656084, European Journal of Medicinal Chemistry, 2012, Ceras, Javier et. al.
Design and synthesis of highly constrained factor Xa inhibitors: amidine-Substituted bis(benzoyl)- [1,3]-diazepan-2-ones and bis(benzylidene)-bis( gem-dimethyl)cycloketones
score: 2.0655916, Bioorganic & Medicinal Chemistry, 2003, Cui, Jian et. al.
Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β
score: 2.0655101, Bioorganic & Medicinal Chemistry, 2003, Minutolo, Filippo et. al.
Design, synthesis and biological activities of sorafenib derivatives as antitumor agents
score: 2.0653084, Bioorganic & Medicinal Chemistry Letters, 2012, Yao, Jianwen et. al.
Design, synthesis and biological activities of sorafenib derivatives as antitumor agents
score: 2.0653084, Bioorganic & Medicinal Chemistry Letters, 2012, Yao, Jianwen et. al.
Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation
score: 2.0652963, Bioorganic & Medicinal Chemistry Letters, 2012, Ongarora, Dennis S.B. et. al.
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0641546, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides
score: 2.0639359, Bioorganic & Medicinal Chemistry, 2012, Nauš, Petr et. al.
3D-QSAR analysis of conformationally constrained diacylglycerol (DAG) analogues as potent protein kinase C (PK-C) ligands
score: 2.0638287, Bioorganic & Medicinal Chemistry, 2004, Kim, Su Yeon; Lee, Jeewoo
Parallel liquid synthesis of N, N′-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors
score: 2.0634176, Bioorganic & Medicinal Chemistry, 2003, Le Diguarher, Thierry et. al.
New potent cathepsin G phosphonate inhibitors
score: 2.0634102, Bioorganic & Medicinal Chemistry, 2008, Sieńczyk, Marcin et. al.
Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y 1 receptor antagonists
score: 2.0628355, Bioorganic & Medicinal Chemistry, 2004, Mathieu, Romain et. al.
Regiospecific one-pot synthesis of pyrimido[4,5- d]pyrimidine derivatives in the solid state under microwave irradiations
score: 2.062659, Bioorganic & Medicinal Chemistry Letters, 2006, Prajapati, Dipak; Gohain, Mukut; Thakur, Ashim J.
Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4
score: 2.0622363, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Renren et. al.
Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library
score: 2.062213, Bioorganic & Medicinal Chemistry, 2005, Sagi, Kazuyuki et. al.
A model for identifying HERG K + channel blockers
score: 2.0617439, Bioorganic & Medicinal Chemistry, 2004, Aronov, Alex M.; Goldman, Brian B.
Synthesis and SAR studies of bicyclic amine series GPR119 agonists
score: 2.0614995, Bioorganic & Medicinal Chemistry Letters, 2012, Sakairi, Masao et. al.
[( S)-γ-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
score: 2.060685, Bioorganic & Medicinal Chemistry, 2006, Sakashita, Hiroshi et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycles leading to the discovery of TMC647055
score: 2.0605383, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists
score: 2.0605276, Bioorganic & Medicinal Chemistry Letters, 2012, Davies, David J. et. al.
Pyrazolopyridine inhibitors of B-RafV600E. Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors
score: 2.0603449, Bioorganic & Medicinal Chemistry Letters, 2012, Wenglowsky, Steve et. al.
Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure–activity relationships
score: 2.0603362, Bioorganic & Medicinal Chemistry Letters, 2012, Reid, Carolyn S. et. al.
Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure–activity relationships
score: 2.0603362, Bioorganic & Medicinal Chemistry Letters, 2012, Reid, Carolyn S. et. al.
Synthesis of [19, 35, 36- 13C 3]-labeled TAK779 as a molecular probe
score: 2.0602185, Bioorganic & Medicinal Chemistry, 2009, Konno, Hiroyuki et. al.
Antileishmanial Bis-arylimidamides: DB766 Analogs Modified in the Linker Region and Bis-arylimidamide Structure-activity Relationships
score: 2.0600286, Bioorganic & Medicinal Chemistry Letters, 2012, Reid, Carolyn S. et. al.
Synthesis, Biological Evaluation and Molecular Docking Studies of 3-(Triazolyl)-coumarin Derivatives: Effect on Inducible Nitric Oxide Synthase
score: 2.059357, European Journal of Medicinal Chemistry, 2012, Stefani, Hélio A. et. al.
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3- d]pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors
score: 2.0589361, Bioorganic & Medicinal Chemistry, 2005, Matulenko, Mark A. et. al.
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors
score: 2.0584543, Bioorganic & Medicinal Chemistry, 2012, Alipour, Masoumeh et. al.
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors
score: 2.0584543, Bioorganic & Medicinal Chemistry, 2012, Alipour, Masoumeh et. al.
Molecular docking and 3D-QSAR studies of Yersinia protein tyrosine phosphatase YopH inhibitors
score: 2.0580259, Bioorganic & Medicinal Chemistry, 2005, Hu, Xin; Erec Stebbins, C.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
score: 2.0577575, European Journal of Medicinal Chemistry, 2012, Menendez, Christophe et. al.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
score: 2.0577575, European Journal of Medicinal Chemistry, 2012, Menendez, Christophe et. al.
1,4-Dihydro-2,3-quinoxalinediones as potential flavin metabolites and excitatory amino acid receptor ligands. Part 1: Synthesis and pharmacological evaluation of the benzylic oxidation series of 1,4-dihydro-6,7-dimethyl-2,3-quinoxalinedione
score: 2.0575183, Bioorganic & Medicinal Chemistry, 1998, Bhat, Ajita et. al.
Pyridonepezils, New Dual AChE inhibitors as Potential Drugs for the Treatment of Alzheimer’s Disease: Synthesis, Biological Assessment, and Molecular Modeling
score: 2.0574629, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators
score: 2.0573872, Bioorganic & Medicinal Chemistry, 2006, Avila, Carolina Martins et. al.
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: Docking-based CoMFA and CoMSIA analyses
score: 2.0570584, European Journal of Medicinal Chemistry, 2009, Cichero, Elena et. al.
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides
score: 2.0565391, Bioorganic & Medicinal Chemistry, 2006, George, Tesmol G. et. al.
6-Substituted 6 H-dibenzo[ c, h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity
score: 2.0564867, Bioorganic & Medicinal Chemistry, 2006, Zhu, Shejin et. al.
Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners
score: 2.0563146, European Journal of Medicinal Chemistry, 2012, Abu-Aisheh, Marwa N. et. al.
Triazoloamides as Potent γ-Secretase Modulators with Reduced hERG Liability
score: 2.0562768, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Isoquinoline derivatives as potent CRTH2 receptor antagonists: Synthesis and SAR
score: 2.056176, Bioorganic & Medicinal Chemistry Letters, 2012, Nishikawa-Shimono, Rie et. al.
Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors
score: 2.0561399, Bioorganic & Medicinal Chemistry, 2012, Lawrence Woo, L.W. et. al.
Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors
score: 2.0561399, Bioorganic & Medicinal Chemistry, 2012, Lawrence Woo, L.W. et. al.
Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol
score: 2.055498, Bioorganic & Medicinal Chemistry, 2006, Bernardes, Lilian Sibelle Campos et. al.
Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase
score: 2.0554532, Bioorganic & Medicinal Chemistry Letters, 2012, Heasley, Brian H. et. al.
Synthesis ofN4-(substituted phenyl)-N4-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells
score: 2.0551744, Bioorganic & Medicinal Chemistry, 2013, Gangjee, Aleem et. al.
Comparative molecular field analysis of non-steroidal aromatase inhibitors: an extended model for two different structural classes
score: 2.0551515, Bioorganic & Medicinal Chemistry, 1998, Recanatini, Maurizio; Cavalli, Andrea
Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti- Mycobacterium activity
score: 2.0547322, Bioorganic & Medicinal Chemistry, 2006, Kamal, Ahmed et. al.
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors
score: 2.0546564, Bioorganic & Medicinal Chemistry Letters, 2012, Radi, Marco et. al.
Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine
score: 2.0546131, Bioorganic & Medicinal Chemistry, 2004, Wamberg, Michael et. al.
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3- d]pyrimidine series
score: 2.0541959, Bioorganic & Medicinal Chemistry, 2005, Amblard, Franck et. al.
Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia
score: 2.0541015, Bioorganic & Medicinal Chemistry Letters, 2012, Cutshall, Neil S. et. al.
Microwave assisted synthesis of spirocyclic pyrrolidines –σ1 receptor ligands with modified benzene-N-distance
score: 2.0537998, European Journal of Medicinal Chemistry, 2012, Jasper, Annemarie et. al.
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy
score: 2.0537857, Bioorganic & Medicinal Chemistry Letters, 2012, Liddle, John et. al.
Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells
score: 2.0535994, Bioorganic & Medicinal Chemistry, 2012, Barcelos, Rosimeire Coura et. al.
Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells
score: 2.0535994, Bioorganic & Medicinal Chemistry, 2012, Barcelos, Rosimeire Coura et. al.
Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells
score: 2.0535994, Bioorganic & Medicinal Chemistry, 2012, Barcelos, Rosimeire Coura et. al.
Synthesis and biological activities of new 1α,25-dihydroxy-19-norvitamin D 3 analogs with modifications in both the A-ring and the side chain
score: 2.0533643, Bioorganic & Medicinal Chemistry, 2006, Shimizu, Masato et. al.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0527043, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0527043, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
score: 2.0527043, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Naohisa et. al.
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore
score: 2.0526356, Bioorganic & Medicinal Chemistry, 2006, Nguyen, Tam Luong et. al.
Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties
score: 2.0522838, European Journal of Medicinal Chemistry, 2012, Luzina, Elena L.; Popov, Anatoliy V.
Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s
score: 2.0520733, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s
score: 2.0520733, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Riccardin C derivatives as anti-MRSA agents: Structure–activity relationship of a series of hydroxylated bis(bibenzyl)s
score: 2.0520733, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.0515738, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.0515738, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters
score: 2.0511685, Bioorganic & Medicinal Chemistry, 2004, Zhang, Shijun et. al.
Synthesis and structure–activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors
score: 2.0511374, Bioorganic & Medicinal Chemistry Letters, 2012, Kumar, Arun Babu et. al.
Synthesis and structure–activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors
score: 2.0511374, Bioorganic & Medicinal Chemistry Letters, 2012, Kumar, Arun Babu et. al.
A new structural alternative in benzo[ b]furans for antimicrobial activity
score: 2.0510489, Bioorganic & Medicinal Chemistry, 2005, Wahab Khan, M. et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus Kinase 2 (JAK2) inhibitors
score: 2.0509339, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
Stochastic entropy QSAR for the in silico discovery of anticancer compounds: Prediction, synthesis, and in vitro assay of new purine carbanucleosides
score: 2.0507758, Bioorganic & Medicinal Chemistry, 2006, González-Díaz, Humberto et. al.
Short synthesis and antimalarial activity of fagaronine
score: 2.0506444, Bioorganic & Medicinal Chemistry, 2012, Rivaud, M. et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 2.0504432, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 2.0504432, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors
score: 2.0504305, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ligong et. al.
Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors
score: 2.050405, Bioorganic & Medicinal Chemistry Letters, 2013, Pecic, Stevan et. al.
Unified QSAR approach to antimicrobials. Part 2: Predicting activity against more than 90 different species in order to halt antibacterial resistance
score: 2.049957, Bioorganic & Medicinal Chemistry, 2007, Prado-Prado, Francisco J. et. al.
Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators
score: 2.0499348, Bioorganic & Medicinal Chemistry Letters, 2012, Packiarajan, Mathivanan et. al.
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors
score: 2.0499077, Bioorganic & Medicinal Chemistry, 2006, Soper, David L. et. al.
Sulfonilamidothiopyrimidone and thiopyrimidone derivatives as selective COX-2 inhibitors: Synthesis, biological evaluation, and docking studies
score: 2.049802, European Journal of Medicinal Chemistry, 2012, Basile, Livia et. al.
Analogues of the potential antipsychotic agent 1192U90: amide modifications
score: 2.049753, Bioorganic & Medicinal Chemistry, 1998, Navas III, Frank et. al.
Facile synthesis of de-O-sulfated salacinols: Revision of the structure of neosalacinol, a potent α-glucosidase inhibitor
score: 2.0489907, Bioorganic & Medicinal Chemistry Letters, 2009, Tanabe, Genzoh et. al.
Polysubstituted pyrazoles, part 5. 1 1 For part 4: see Ref. [18]. Synthesis of new 1-(4-chlorophenyl)-4-hydroxy-1 H-pyrazole-3-carboxylic acid hydrazide analogs and some derived ring systems. A novel class of potential antitumor and anti-HCV agents
score: 2.048951, European Journal of Medicinal Chemistry, 2003, Rostom, Sherif A.F; Shalaby, Manal A; El-Demellawy, Maha A
Structure–activity relationships of arylbenzofuran H 3 receptor antagonists
score: 2.0479644, Bioorganic & Medicinal Chemistry Letters, 2005, Gfesser, Gregory A. et. al.
Biological characterization of novel inhibitors of the gram-positive DNA polymerase IIIC enzyme.
score: 2.0478068, Antimicrobial agents and chemotherapy, 2005, Kuhl, Alexander et. al.
Synthesis and biological properties of new 5-nitroindazole derivatives
score: 2.0468795, Bioorganic & Medicinal Chemistry, 2005, Arán, Vicente J. et. al.
Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors
score: 2.0463483, Bioorganic & Medicinal Chemistry, 2001, Aoyama, Yasunori et. al.
A new series of N5 derivatives of the 1,1,5-trimethylfuro[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes
score: 2.0460247, Bioorganic & Medicinal Chemistry Letters, 2012, Pham, The Hien et. al.
Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
score: 2.0452897, Antimicrobial agents and chemotherapy, 2012, Eakin, Ann E et. al.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
score: 2.0447957, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xianfeng et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 2.0445229, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 2.0445229, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 2.0445229, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation
score: 2.0438359, Bioorganic & Medicinal Chemistry Letters, 2012, Procopiou, Panayiotis A. et. al.
Discovery of a Novel Series of 4-Quinolone JNK Inhibitors
score: 2.0432997, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Leyi et. al.
Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents
score: 2.042124, Bioorganic & Medicinal Chemistry Letters, 2012, Gavade, Sandip N. et. al.
Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents
score: 2.042124, Bioorganic & Medicinal Chemistry Letters, 2012, Gavade, Sandip N. et. al.
Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the α-ketoacid motif
score: 2.0420781, Bioorganic & Medicinal Chemistry, 2004, Chen, Yen Ting; Seto, Christopher T
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization
score: 2.0417949, Bioorganic & Medicinal Chemistry, 2012, Prakasham, A.P. et. al.
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization
score: 2.0417949, Bioorganic & Medicinal Chemistry, 2012, Prakasham, A.P. et. al.
Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives
score: 2.0417756, Bioorganic & Medicinal Chemistry Letters, 2013, Castro-Castillo, Vicente et. al.
Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles
score: 2.0413633, Bioorganic & Medicinal Chemistry Letters, 2006, Minhas, Gurpreet Singh et. al.
Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU
score: 2.0411408, European Journal of Medicinal Chemistry, 2012, Min, Jun; Lin, Da; Zhang, Qingye; Zhang, Jibing; Yu, Ziniu
Virtual screening leads to the discovery of novel non-nucleotide P2Y1 receptor antagonists
score: 2.0409121, Bioorganic & Medicinal Chemistry, 2012, Costanzi, Stefano et. al.
Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo
score: 2.0408755, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Hui; He, Xiao-Qiang
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0402644, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0402644, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors
score: 2.0402644, Bioorganic & Medicinal Chemistry Letters, 2012, Moure, Alejandra et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 2.0398025, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 2.0398025, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphospate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 2.0398025, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR
score: 2.0396099, Bioorganic & Medicinal Chemistry, 2006, Tamura, Hiroto et. al.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
score: 2.039079, European Journal of Medicinal Chemistry, 2012, Menendez, Christophe et. al.
Design and synthesis of N-benzylpiperidine–purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase
score: 2.0388145, Bioorganic & Medicinal Chemistry, 2005, Rodríguez-Franco, María Isabel et. al.
Design, synthesis and early structure–activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate
score: 2.037935, Bioorganic & Medicinal Chemistry, 2000, Schlitzer, Martin et. al.
Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
score: 2.0376611, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
score: 2.0376611, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
A new inhibitor design strategy for carboxypeptidase A as exemplified by N-(2-chloroethyl)- N-methylphenylalanine
score: 2.0375778, Bioorganic & Medicinal Chemistry, 2001, Park, Jung Dae; Lee, Kyung Joo; Kim, Dong H.
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH 3 receptor affinities
score: 2.0375541, Bioorganic & Medicinal Chemistry, 2003, Graßmann, Sven et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0375322, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Structure–activity relationships of globomycin analogues as antibiotics
score: 2.0373376, Bioorganic & Medicinal Chemistry, 2004, Kiho, Toshihiro et. al.
Synthesis and SAR of tetracyclic pyrroloquinolones as phosphodiesterase 5 inhibitors
score: 2.0371516, Bioorganic & Medicinal Chemistry, 2004, Jiang, Weiqin et. al.
Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A
score: 2.0371259, Bioorganic & Medicinal Chemistry, 2006, Park, Jewn Giew et. al.
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
score: 2.0370042, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Synthesis and anticancer activity of a series of norcantharidin analogues
score: 2.0368929, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH 2 derivatives
score: 2.0367983, Bioorganic & Medicinal Chemistry, 1996, Weng, Jian Hui et. al.
Molecular Modeling, Structure–Activity Relationships and Functional Antagonism Studies of 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketones as a Novel Class of Dopamine Transporter Inhibitors
score: 2.0364879, Bioorganic & Medicinal Chemistry, 2001, Wang, Shaomeng et. al.
Bicyclic carbohydrate-derived scaffolds for combinatorial libraries
score: 2.0364625, Bioorganic & Medicinal Chemistry, 2006, Cervi, Giovanni et. al.
Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones
score: 2.0360392, European Journal of Medicinal Chemistry, 2006, Anquetin, Guillaume et. al.
Contribution to investigation of antimicrobial activity of styrylquinolines
score: 2.0359869, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Contribution to investigation of antimicrobial activity of styrylquinolines
score: 2.0359869, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Contribution to investigation of antimicrobial activity of styrylquinolines
score: 2.0359869, Bioorganic & Medicinal Chemistry, 2012, Cieslik, Wioleta et. al.
Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives
score: 2.0355668, Bioorganic & Medicinal Chemistry, 2006, Costa, Marilia S. et. al.
Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones
score: 2.0349344, Bioorganic & Medicinal Chemistry, 2002, Bruno, G et. al.
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives
score: 2.0338431, Bioorganic & Medicinal Chemistry, 2005, Wang, Tai-Chi et. al.
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
score: 2.0337367, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Junxing et. al.
3D-QSAR studies of pyruvate dehydrogenase kinase inhibitors based on a divide and conquer strategy
score: 2.033443, Bioorganic & Medicinal Chemistry, 2004, Aboye, Teshome Leta et. al.
Synthesis and Biological Properties of Amino Acid Amide Ligand-Based Pyridinioalkanoyl Thioesters as Anti-HIV Agents
score: 2.0330847, Bioorganic & Medicinal Chemistry, 2002, Song, Yongsheng et. al.
Bisquaternary caracurine V and iso-caracurine V salts as ligands for the muscle type of nicotinic acetylcholine receptors: SAR and QSAR studies
score: 2.0329276, Bioorganic & Medicinal Chemistry, 2004, Zlotos, D.P. et. al.
The cytotoxicity of ortho alkyl substituted 4-X-phenols: A QSAR based on theoretical bond lengths and electron densities
score: 2.0323665, Bioorganic & Medicinal Chemistry Letters, 2006, Loader, R.J.; Singh, N.; O’Malley, P.J.; Popelier, P.L.A.
Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores
score: 2.0322233, Bioorganic & Medicinal Chemistry, 2006, Koufaki, Maria et. al.
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
score: 2.0322075, Bioorganic & Medicinal Chemistry Letters, 2012, Hansen, Finn K. et. al.
Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1
score: 2.0312991, Bioorganic & Medicinal Chemistry, 2006, Lazo, John S. et. al.
Three-dimensional quantitative structure–activity relationship (3 D-QSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors
score: 2.0312556, Bioorganic & Medicinal Chemistry Letters, 2006, Shaikh, Abdul Rajjak et. al.
Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent
score: 2.0306356, Bioorganic & Medicinal Chemistry Letters, 2012, Hatnapure, Girish D. et. al.
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 2.0306091, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 2.0306091, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 2.0306091, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists
score: 2.0305613, Bioorganic & Medicinal Chemistry Letters, 2013, Fevig, John M. et. al.
Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers
score: 2.0303903, Bioorganic & Medicinal Chemistry Letters, 2012, Kers, Inger et. al.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 2.0303774, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain
score: 2.0303701, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain
score: 2.0303701, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain
score: 2.0303701, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
score: 2.0295312, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
score: 2.0295312, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 2.0292827, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 2.0292827, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 2.0292827, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
A facile route to paclitaxel C-10 carbamates
score: 2.0290584, Bioorganic & Medicinal Chemistry Letters, 2005, Ballatore, Carlo et. al.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs
score: 2.0287126, Bioorganic & Medicinal Chemistry Letters, 2012, Ochiana, Stefan O. et. al.
Biaryl diacid inhibitors of human s-PLA 2 with anti-inflammatory activity
score: 2.0281779, Bioorganic & Medicinal Chemistry, 2000, Springer, Dane M. et. al.
Construction of a three-dimensional pharmacophore for Bcl-2 inhibitors by flexible docking and the multiple copy simultaneous search method
score: 2.0274409, Bioorganic & Medicinal Chemistry, 2007, Zheng, Can-Hui et. al.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0273767, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
score: 2.0273336, European Journal of Medicinal Chemistry, 2012, Bargiotti, Alberto et. al.
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
score: 2.0273336, European Journal of Medicinal Chemistry, 2012, Bargiotti, Alberto et. al.
Identification of a dual δ OR antagonist/ μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)
score: 2.027251, Bioorganic & Medicinal Chemistry Letters, 2012, Breslin, Henry J. et. al.
Synthesis and biological evaluation of B-ring analogues of (−)-rhazinilam
score: 2.026963, Bioorganic & Medicinal Chemistry, 2006, Décor, Anne et. al.
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
score: 2.0267053, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
score: 2.0267053, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
score: 2.0267053, Bioorganic & Medicinal Chemistry Letters, 2012, Chu, Lin et. al.
Conformationally rigid N-acyl-5-alkyl- l-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors
score: 2.0254761, Bioorganic & Medicinal Chemistry, 2003, Wallén, Erik A.A. et. al.
Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases
score: 2.0251869, Bioorganic & Medicinal Chemistry, 2006, Bhuiyan, Mohammed P.I. et. al.
Novel cinnoline-based inhibitors of LRRK2 kinase activity
score: 2.0251865, Bioorganic & Medicinal Chemistry Letters, 2013, Garofalo, Albert W. et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors
score: 2.0250364, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
The 3D-QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and CoMSIA
score: 2.0248874, Bioorganic & Medicinal Chemistry, 2003, Park Choo, Hea-Young et. al.
Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents
score: 2.0248488, European Journal of Medicinal Chemistry, 2006, Abadi, Ashraf H. et. al.
Synthesis and structure–activity relationships of potent and orally active sulfonamide ET B selective antagonists
score: 2.0247361, Bioorganic & Medicinal Chemistry, 2001, Kanda, Yasuhiko et. al.
Non-Peptidic inhibitors of human chymase. Synthesis, structure–activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones
score: 2.0235023, Bioorganic & Medicinal Chemistry, 2001, Akahoshi, Fumihiko et. al.
Isoquinoline derivatives as potent CRTH2 receptor antagonists: Synthesis and SAR
score: 2.0231947, Bioorganic & Medicinal Chemistry Letters, 2012, Nishikawa-Shimono, Rie et. al.
A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers
score: 2.0221272, Bioorganic & Medicinal Chemistry Letters, 2007, Fauq, Abdul H. et. al.
Tyrosinase inhibitory cycloartane type triterpenoids from the methanol extract of the whole plant of Amberboa ramosa Jafri and their structure–activity relationship
score: 2.0220967, Bioorganic & Medicinal Chemistry, 2006, Khan, Mahmud Tareq Hassan et. al.
Identification of specific features of inhibition of PKCβII and its potential lead by shape-based virtual screening and molecular docking studies
score: 2.0218591, Bioorganic & Medicinal Chemistry Letters, 2012, Grewal, Baljinder K.; Elizabeth Sobhia, M.
Identification of specific features of inhibition of PKCβII and its potential lead by shape-based virtual screening and molecular docking studies
score: 2.0218591, Bioorganic & Medicinal Chemistry Letters, 2012, Grewal, Baljinder K.; Elizabeth Sobhia, M.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 2.0215452, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 2.0215452, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 2.0215452, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Synthesis and structure–activity relationships of 2-hydrazinyladenosine derivatives as A2A adenosine receptor ligands
score: 2.0210155, Bioorganic & Medicinal Chemistry, 2013, El-Tayeb, Ali; Gollos, Sabrina
Synthesis, biological evaluation and 3D QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
score: 2.0209716, Bioorganic & Medicinal Chemistry, 2012, Li, Cui-Yun et. al.
Parallel synthesis and dopamine D 3/D 2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides
score: 2.0208718, Bioorganic & Medicinal Chemistry, 2005, Heidler, Philipp et. al.
Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover
score: 2.0206553, Bioorganic & Medicinal Chemistry Letters, 2012, Manka, Jason T. et. al.
Discovery of new inhibitors of aldose reductase from molecular docking and database screening
score: 2.0201814, Bioorganic & Medicinal Chemistry, 2002, Rastelli, Giulio et. al.
Identification of Aryl Dihydrouracil Derivatives as Palm Initiation Site Inhibitors of HCV NS5B Polymerase
score: 2.0201554, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yaya et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0196672, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0196672, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite
score: 2.0196672, Bioorganic & Medicinal Chemistry Letters, 2012, Smith, Garry R. et. al.
Riccardin C Derivatives as Anti-MRSA Agents: Structure-Activity Relationship of a Series of Hydroxylated Bis(bibenzyl)s
score: 2.0194425, Bioorganic & Medicinal Chemistry Letters, 2012, Sawada, Hiromi et. al.
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
score: 2.018995, Bioorganic & Medicinal Chemistry Letters, 2012, Le, Phuong T. et. al.
Synthesis, molecular modeling and evaluation of novel N′-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation
score: 2.0185314, Bioorganic & Medicinal Chemistry Letters, 2013, Özturan Özer, Eda et. al.
Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.
score: 2.017882, Antimicrobial agents and chemotherapy, 2012, He, Shanshan et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 2.0176064, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 2.0176064, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 2.0176064, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
2,4-Diamino-9 H-pyrimido[4,5- b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations
score: 2.0172815, Bioorganic & Medicinal Chemistry, 2006, Dotzauer, Bernd et. al.
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity
score: 2.01725, Bioorganic & Medicinal Chemistry Letters, 2012, Axten, Jeffrey M. et. al.
Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 2.0171745, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 2.0171745, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 2.0171745, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
score: 2.0171162, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Probes for Narcotic Receptor Mediated Phenomena. Part 28: New Opioid Antagonists from Enantiomeric Analogues of 5-(3-Hydroxyphenyl)- N-phenylethylmorphan
score: 2.0166324, Bioorganic & Medicinal Chemistry, 2002, Hashimoto, Akihiro et. al.
Exploration of a binding mode of indole amide analogues as potent histone deacetylase inhibitors and 3D-QSAR analyses
score: 2.0162481, Bioorganic & Medicinal Chemistry, 2005, Guo, Yanshen et. al.
Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis
score: 2.0157942, Bioorganic & Medicinal Chemistry, 2006, Xu, Ze-Qi et. al.
Benzofuranones as potential antinociceptive agents: Structure–activity relationships
score: 2.0157211, European Journal of Medicinal Chemistry, 2012, Gonçalves, Cleiton José et. al.
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease
score: 2.0156724, Bioorganic & Medicinal Chemistry Letters, 2012, Sunose, Mihiro et. al.
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease
score: 2.0156724, Bioorganic & Medicinal Chemistry Letters, 2012, Sunose, Mihiro et. al.
Synthesis of furanone-Based natural product analogues with quorum sensing antagonist activity
score: 2.0154048, Bioorganic & Medicinal Chemistry, 2003, Hjelmgaard, Thomas et. al.
Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides
score: 2.0152979, Bioorganic & Medicinal Chemistry, 2000, Chan, Wai N. et. al.
Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3β (GSK-3β) inhibitors
score: 2.0152302, Bioorganic & Medicinal Chemistry, 2004, Shen, Lan et. al.
Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kβ inhibitors
score: 2.0149635, Bioorganic & Medicinal Chemistry Letters, 2012, Certal, Victor et. al.
Fancy bioisosteres: synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist
score: 2.0144504, Bioorganic & Medicinal Chemistry, 2005, Lenz, Carola et. al.
Synthesis and structure–activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium–calcium exchanger
score: 2.0143716, Bioorganic & Medicinal Chemistry, 2004, Kuramochi, Takahiro et. al.
Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: Discovery of novel orally active inhibitors of human thymidine phosphorylase
score: 2.014356, Bioorganic & Medicinal Chemistry, 2004, Yano, Shingo et. al.
Novel imidazole substituted 6-methylidene-penems as broad-spectrum β-lactamase inhibitors
score: 2.0137134, Bioorganic & Medicinal Chemistry, 2004, Venkatesan, Aranapakam M. et. al.
Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
score: 2.0134415, Bioorganic & Medicinal Chemistry, 2012, Tichý, Michal et. al.
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design
score: 2.0132423, Bioorganic & Medicinal Chemistry, 2006, Tsao, Désirée H.H. et. al.
Oxidative aromatization of Hantzsch 1,4-dihydropyridines in the presence of mixed-addenda vanadomolybdophosphate heteropolyacid, H 6PMo 9V 3O 40
score: 2.0130999, Bioorganic & Medicinal Chemistry Letters, 2007, Heravi, Majid M. et. al.
Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring
score: 2.0125871, Bioorganic & Medicinal Chemistry, 2004, Tanitame, Akihiko et. al.
Synthesis of (4 R,15 R,16 R,21 S)- and (4 R,15 S,16 S,21 S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I
score: 2.0125502, Bioorganic & Medicinal Chemistry, 2006, Makabe, Hidefumi et. al.
Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility
score: 2.0124942, Bioorganic & Medicinal Chemistry, 2012, Li, Nian-Guang et. al.
Structure-based prediction of Mycobacterium tuberculosis shikimate kinase inhibitors by high-throughput virtual screening
score: 2.0120863, Bioorganic & Medicinal Chemistry Letters, 2008, Segura-Cabrera, Aldo; Rodríguez-Pérez, Mario A.
Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors
score: 2.0119285, Bioorganic & Medicinal Chemistry, 2003, Wheelock, Craig E. et. al.
Inhibition of HIV-1 capsid assembly; optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 2.0111803, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
Structure-based design and synthesis of small molecule protein–tyrosine phosphatase 1B inhibitors 1 A preliminary account of this work have been reported: Burke, T. R., Jr.; Yao, Z. J.; Ye, B.; Wang, S.; Zhang, Z. Y. Structure-based design of protein–tyrosine phosphatase inhibitors. Presented at the 213th National ACS Meeting, San Francisco, CA, April 13–17, 1997; MEDI-313. 1
score: 2.0110696, Bioorganic & Medicinal Chemistry, 1998, Yao, Zhu-Jun et. al.
Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors
score: 2.0109852, Bioorganic & Medicinal Chemistry, 2004, Ochiai, Hiroshi et. al.
Design, synthesis and biological evaluation of pyridine-phenylpiperazines: A novel series of potent and selective α 1a-adrenergic receptor antagonist
score: 2.0108875, Bioorganic & Medicinal Chemistry, 2000, Kuo, Gee-Hong et. al.
Design, Synthesis, Biochemical Studies, Cellular Characterization, and Structure-Based Computational Studies of Small Molecules Targeting the Urokinase Receptor
score: 2.0108615, Bioorganic & Medicinal Chemistry, 2012, Wang, Fang et. al.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
score: 2.0108378, Bioorganic & Medicinal Chemistry Letters, 2012, Ji, Zhiqin et. al.
Structure-Based design of nonpeptide inhibitors of interleukin-1β converting enzyme (ICE, Caspase-1)
score: 2.0108154, Bioorganic & Medicinal Chemistry, 2002, Shahripour, Aurash B et. al.
Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides
score: 2.0108051, European Journal of Medicinal Chemistry, 2012, Banerjee, Moloy et. al.
New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: Quantitative structure–activity relationship studies
score: 2.0107188, Bioorganic & Medicinal Chemistry, 2005, Aguirre, Gabriela et. al.
Linking CoMFA and protein homology models of enzyme–inhibitor interactions: an application to non-steroidal aromatase inhibitors
score: 2.0106433, Bioorganic & Medicinal Chemistry, 2000, Cavalli, Andrea et. al.
Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore
score: 2.0105818, European Journal of Medicinal Chemistry, 2005, Singh, Sunil K. et. al.
Unbiased binding assays for discovering small-molecule probes and drugs
score: 2.0103881, Bioorganic & Medicinal Chemistry, 2012, Kemp, Melissa M.; Weïwer, Michel; Koehler, Angela N.
Synthesis and biological evaluation of optically active conjugated γ- and δ-lactone derivatives
score: 2.0101562, Bioorganic & Medicinal Chemistry Letters, 2012, Şardan, Melis et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 2.0100312, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 2.0100312, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 2.0100312, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
score: 2.0097174, European Journal of Medicinal Chemistry, 2012, Tukulula, Matshawandile et. al.
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
score: 2.0097174, European Journal of Medicinal Chemistry, 2012, Tukulula, Matshawandile et. al.
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
score: 2.0097174, European Journal of Medicinal Chemistry, 2012, Tukulula, Matshawandile et. al.
Studies on Anti- Helicobacter pylori Agents. Part 1: Benzyloxyisoquinoline Derivatives
score: 2.0096847, Bioorganic & Medicinal Chemistry, 1999, Yoshida, Yoshiki et. al.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.0092506, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.0092506, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia
score: 2.0092506, Bioorganic & Medicinal Chemistry, 2012, Shiohara, Hiroaki et. al.
Convenient synthesis of 3- and 6-deoxy- d- myo-inositol phosphate analogues from (+)- epi- and (−)- vibo-quercitols
score: 2.0085025, Bioorganic & Medicinal Chemistry Letters, 2006, Ogawa, Seiichiro; Tezuka, Yoji
Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
score: 2.008217, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jongkook et. al.
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors
score: 2.0080424, Bioorganic & Medicinal Chemistry Letters, 2012, Close, Joshua et. al.
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors
score: 2.0080424, Bioorganic & Medicinal Chemistry Letters, 2012, Close, Joshua et. al.
Synthesis and antibacterial activity of 4″- O-heteroarylcarbamoyl derivatives of macrolide
score: 2.0080009, Bioorganic & Medicinal Chemistry Letters, 2008, Xu, Peng et. al.
Syntheses and structure–activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents
score: 2.0079579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Syntheses and structure–activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents
score: 2.0079579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Syntheses and structure–activity relationship studies of N-substituted-β-d-glucosaminides as selective cytotoxic agents
score: 2.0079579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
score: 2.007647, Bioorganic & Medicinal Chemistry Letters, 2012, Baciu-Atudosie, Lavinia et. al.
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
score: 2.007647, Bioorganic & Medicinal Chemistry Letters, 2012, Baciu-Atudosie, Lavinia et. al.
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
score: 2.007647, Bioorganic & Medicinal Chemistry Letters, 2012, Baciu-Atudosie, Lavinia et. al.
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor
score: 2.0073487, Bioorganic & Medicinal Chemistry Letters, 2012, Martínez González, Sonia et. al.
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor
score: 2.0073487, Bioorganic & Medicinal Chemistry Letters, 2012, Martínez González, Sonia et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 2.0070385, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 2.0070385, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 2.0070385, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety
score: 2.0068233, European Journal of Medicinal Chemistry, 2012, Feng, Lianshun et. al.
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors
score: 2.0068073, Bioorganic & Medicinal Chemistry Letters, 2012, Pajouhesh, Hassan et. al.
Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A
score: 2.0067262, Bioorganic & Medicinal Chemistry, 2006, Merino, Isidro et. al.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
score: 2.0066595, Bioorganic & Medicinal Chemistry Letters, 2012, Ji, Zhiqin et. al.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
score: 2.0066595, Bioorganic & Medicinal Chemistry Letters, 2012, Ji, Zhiqin et. al.
Important pharmacophoric features of pan PPAR agonists: Common chemical feature analysis and virtual screening
score: 2.0062181, European Journal of Medicinal Chemistry, 2009, Sundriyal, Sandeep; Bharatam, Prasad V.
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
score: 2.0056247, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes
score: 2.0051793, Bioorganic & Medicinal Chemistry, 2006, Crane, Louis et. al.
A cyclic PNA-based compound targeting domain IV of HCV IRES RNA inhibits in vitro IRES-dependent translation
score: 2.0051682, Bioorganic & Medicinal Chemistry, 2005, Caldarelli, Sergio A. et. al.
Novel strategies for the solid phase synthesis of substituted indolines and indoles
score: 2.0051613, Bioorganic & Medicinal Chemistry, 2003, Nicolaou, K.C et. al.
Using self-organizing maps to accelerate similarity search
score: 2.0050237, Bioorganic & Medicinal Chemistry, 2012, Bonachera, Fanny et. al.
Using self-organizing maps to accelerate similarity search
score: 2.0050237, Bioorganic & Medicinal Chemistry, 2012, Bonachera, Fanny et. al.
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine
score: 2.0043429, European Journal of Medicinal Chemistry, 2012, Annedi, Subhash C. et. al.
Chemical methods for the synthesis and modification of neoclerodane diterpenes
score: 2.0042201, Bioorganic & Medicinal Chemistry Letters, 2009, Lozama, Anthony; Prisinzano, Thomas E.
CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]- N, N ′-diphenylureas
score: 2.0039594, Bioorganic & Medicinal Chemistry, 2004, Imamura, Shinichi et. al.
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical conformation
score: 2.0031189, Bioorganic & Medicinal Chemistry, 1997, Albert, Jeffrey S.; Peczuh, Mark W.; Hamilton, Andrew D.
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical conformation
score: 2.0031189, Bioorganic & Medicinal Chemistry, 1997, Albert, Jeffrey S.; Peczuh, Mark W.; Hamilton, Andrew D.
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
score: 2.0029286, Bioorganic & Medicinal Chemistry Letters, 2012, Le, Phuong T. et. al.
SAR Studies of 3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one as Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase
score: 2.0027185, Bioorganic & Medicinal Chemistry, 2002, Lin, Yung-Lung et. al.
New potential inhibitors of DNA topoisomerase. Part II: Design and synthesis of α-lapachone derivatives under microwave irradiation
score: 2.0026727, Bioorganic & Medicinal Chemistry Letters, 2009, Wei, Ping et. al.
Disubstituted piperidines as potent Orexin (hypocretin) receptor antagonists
score: 2.0025712, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Rong et. al.
Pharmacology of novel heteroaromatic polycycle antibacterials.
score: 2.0025579, Antimicrobial agents and chemotherapy, 2003, Gross, M et. al.
Synthesis and antiviral activity of 4,4′-(arylmethylene)bis(1 H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV)
score: 2.0025191, Bioorganic & Medicinal Chemistry Letters, 2009, Sujatha, Kuppusamy et. al.
Comparative molecular field analysis and comparative molecular similarity indices analysis of human thymidine kinase 1 substrates
score: 2.0021696, Bioorganic & Medicinal Chemistry, 2005, Bandyopadhyaya, Achintya K. et. al.
3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis
score: 2.0020988, Bioorganic & Medicinal Chemistry, 2005, Bhongade, Bhoomendra A. et. al.
Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5- c]pyridine bioisosteres of arecoline
score: 2.0018079, Bioorganic & Medicinal Chemistry, 1999, Pedersen, Henrik et. al.
Exploring the PDE5 H-pocket by Ensemble Docking and Structure-based Design and Synthesis of Novel β-Carboline Derivatives
score: 2.0017149, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa
score: 2.0016334, Bioorganic & Medicinal Chemistry, 2005, Zhan, Zha-Jun; Fan, Cheng-Qi; Ding, Jian; Yue, Jian-Min
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 2.0014001, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 2.0014001, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 2.0014001, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity
score: 2.0011495, Bioorganic & Medicinal Chemistry, 2005, Büttner, Frank et. al.
Synthesis of complex δ-acetylenic amino acids as potential multisubstrate adduct inhibitors of methyltransferases
score: 2.0010322, Bioorganic & Medicinal Chemistry, 1996, Burns, Mark R.; Coward, James K.
Theoretical study of gas-phase acidity, p K a, lipophilicity, and solubility of some biologically active sulfonamides
score: 2.0008693, Bioorganic & Medicinal Chemistry, 2004, Remko, Milan; von der Lieth, Claus-Wilhelm
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0004304, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0004304, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
score: 2.0004304, Bioorganic & Medicinal Chemistry Letters, 2012, Mori, Yutaka et. al.
A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α,25-dihydroxyvitamin D 3: synthesis and preliminary biological evaluation
score: 2.00032, Bioorganic & Medicinal Chemistry, 2005, Hatcher, Mark A. et. al.
DFT-based ranking of zinc-binding groups in histone deacetylase inhibitors
score: 1.999762, Bioorganic & Medicinal Chemistry, 2005, Vanommeslaeghe, K.; Loverix, S.; Geerlings, P.; Tourwé, D.
Novel acridinedione derivatives: Design, Synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
score: 1.9987524, Bioorganic & Medicinal Chemistry Letters, 2012, Alvala, Mallika et. al.
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines
score: 1.9986523, Bioorganic & Medicinal Chemistry, 2005, Moon, Byung Seok; Lee, Byoung Se; Chi, Dae Yoon
Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2
score: 1.9986091, Bioorganic & Medicinal Chemistry Letters, 2012, Delouvrié, Bénédicte et. al.
Synthesis of indolizidinone analogues of cytotoxic alkaloids: monocyclic precursors are also active
score: 1.9985987, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues
score: 1.9983228, Bioorganic & Medicinal Chemistry Letters, 1998, Highfield, Jackie A. et. al.
Design, synthesis and structure–activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.9981628, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression
score: 1.9980151, Bioorganic & Medicinal Chemistry Letters, 2013, Gillman, Kevin W. et. al.
Pleuromutilins. Part 1
score: 1.997613, Bioorganic & Medicinal Chemistry, 2001, Brooks, Gerald et. al.
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives
score: 1.9975048, Bioorganic & Medicinal Chemistry Letters, 2012, LeTourneau, Nicolas et. al.
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives
score: 1.9975048, Bioorganic & Medicinal Chemistry Letters, 2012, LeTourneau, Nicolas et. al.
Synthesis of new bergenin derivatives as potent inhibitors of inflammatory mediators NO and TNF-α
score: 1.9974694, Bioorganic & Medicinal Chemistry Letters, 2012, Shah, Muhammad Raza et. al.
Combinatorial chemistry of hydantoins
score: 1.9973869, Bioorganic & Medicinal Chemistry Letters, 1998, Boeijen, Astrid; Kruijtzer, John A.W; Liskamp, Rob M.J
HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo- 2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy- 2H-quinolizin-2-one derivatives
score: 1.9972004, Bioorganic & Medicinal Chemistry Letters, 2009, Wang, Guangyi et. al.
Development of first photoresponsive prodrug of paclitaxel
score: 1.9969594, Bioorganic & Medicinal Chemistry Letters, 2006, Skwarczynski, Mariusz et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
score: 1.9965499, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
score: 1.9965499, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
score: 1.9965499, Bioorganic & Medicinal Chemistry Letters, 2012, Vendeville, Sandrine et. al.
11 H-Isoquino[4,3- c]cinnolin-12-ones
score: 1.9956233, Bioorganic & Medicinal Chemistry, 2004, Ruchelman, Alexander L et. al.
Design and synthesis of 4H-3-(2-Phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists
score: 1.9951512, Bioorganic & Medicinal Chemistry, 2003, Akbarzadeh, Tahmineh et. al.
Design and an efficient synthesis of new thiorotenone derivatives
score: 1.9950745, Bioorganic & Medicinal Chemistry Letters, 2010, Yao, Changsheng et. al.
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
score: 1.9947721, Bioorganic & Medicinal Chemistry Letters, 2012, Chang, Wonsuk et. al.
Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells
score: 1.994681, Bioorganic & Medicinal Chemistry Letters, 2013, Yoon, Hyuk et. al.
Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: A single-step synthesis from benzenesulfonamide via hemiaminal
score: 1.994389, European Journal of Medicinal Chemistry, 2007, Singh, Sunil K. et. al.
Efficient synthesis of 3′-glycosylated LacNAc-based oligosaccharides
score: 1.9941771, Bioorganic & Medicinal Chemistry Letters, 1998, Ding, Yili; Fukuda, Minrou; Hindsgaul, Ole
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry
score: 1.9939713, Bioorganic & Medicinal Chemistry, 2008, Lam, Son N. et. al.
Design, Synthesis and Biological Evaluation of Potent NAD+-dependent DNA Ligase Inhibitors as Potential Antibacterial Agents. Part I: Aminoalkoxypyrimidine Carboxamides
score: 1.9937359, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Synthesis, screening and quantitative structure–activity relationship (QSAR) studies of some glutamine analogues for possible anticancer activity
score: 1.9936147, Bioorganic & Medicinal Chemistry, 2002, Srikanth, K.; Kumar, Ch.Anil; Ghosh, Balaram; Jha, Tarun
Synthesis and SAR Development of Novel mGluR1 Antagonists for the Treatment of Chronic Pain
score: 1.9932479, Bioorganic & Medicinal Chemistry Letters, 2012, Brumfield, Stephanie et. al.
CoMFA, LeapFrog and blind docking studies on sulfonanilide derivatives acting as selective aromatase expression regulators
score: 1.9930291, European Journal of Medicinal Chemistry, 2009, Gueto, Carlos; Torres, Juan; Vivas-Reyes, Ricardo
Known drug space as a metric in exploring the boundaries of drug-like chemical space
score: 1.9922456, European Journal of Medicinal Chemistry, 2009, Mirza, Amin; Desai, Radha; Reynisson, Jóhannes
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists
score: 1.9921353, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists
score: 1.9921353, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists
score: 1.9921353, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
Novel vitamin D 3 antipsoriatic antedrugs: 16-En-22-oxa-1α,25-(OH) 2D 3 analogs
score: 1.9921348, Bioorganic & Medicinal Chemistry, 2006, Shimizu, Kazuki et. al.
Thiorhodamines Containing Amide and Thioamide Functionality as Inhibitors of the ATP-Binding Cassette Drug Transporter P-glycoprotein (ABCB1)
score: 1.9917046, Bioorganic & Medicinal Chemistry, 2012, Orchard, Alexandra et. al.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
score: 1.9916825, Bioorganic & Medicinal Chemistry Letters, 2012, Bode, Christiane M. et. al.
Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents
score: 1.9912572, Bioorganic & Medicinal Chemistry, 2006, Rochais, C.; Lisowski, V.; Dallemagne, P.; Rault, S.
A novel photoaffinity probe for the LTD 4 receptor
score: 1.9911621, Bioorganic & Medicinal Chemistry, 1998, Gallant, Michel et. al.
Preparation, antibacterial evaluation and preliminary structure–activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives
score: 1.9910585, Bioorganic & Medicinal Chemistry Letters, 2012, Ouyang, Liang et. al.
A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure–activity relationships
score: 1.9910124, Bioorganic & Medicinal Chemistry, 2005, Nomura, Takashi et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.9907447, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.9907447, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
In vitro solubility, stability and permeability of novel quercetin–amino acid conjugates
score: 1.9906238, Bioorganic & Medicinal Chemistry, 2009, Kim, Mi Kyoung et. al.
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.9905811, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.9905811, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.9905811, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1
score: 1.9902691, Bioorganic & Medicinal Chemistry Letters, 2000, Uckun, Fatih M. et. al.
Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems
score: 1.9892515, Bioorganic & Medicinal Chemistry, 2000, Imamura, Hideaki et. al.
Design, synthesis and Structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.9890826, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins
score: 1.988991, Bioorganic & Medicinal Chemistry, 2005, LeBlanc, Regan et. al.
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening
score: 1.9881919, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Siyuan et. al.
Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives
score: 1.9872957, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Molecular encapsulation of 5-nitroindazole derivatives in 2,6-dimethyl-β-cyclodextrin: Electrochemical and spectroscopic studies
score: 1.9867941, Bioorganic & Medicinal Chemistry, 2009, Pérez-Cruz, Fernanda et. al.
Syntheses of novel heterocycles as anticancer agents
score: 1.9866842, Bioorganic & Medicinal Chemistry, 2005, Chauhan, Prem M.S. et. al.
Design, synthesis and structure–activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.9865494, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Syntheses and DNA-binding studies of a series of unsymmetrical cyanine dyes: structural influence on the degree of minor groove binding to natural DNA
score: 1.9864574, Bioorganic & Medicinal Chemistry, 2004, Karlsson, H.Jonas et. al.
Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels
score: 1.9857253, Bioorganic & Medicinal Chemistry Letters, 2013, Ortar, Giorgio et. al.
Coumarin–trioxane hybrids: Synthesis and evaluation as a new class of antimalarial scaffolds
score: 1.9855804, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human β 3-adrenergic receptor agonists with high cell permeability
score: 1.98547, Bioorganic & Medicinal Chemistry, 2005, Mizuno, Kazuhiro et. al.
Novel AI-2 quorum sensing inhibitors in Vibrio harveyi identified through structure-based virtual screening
score: 1.9851763, Bioorganic & Medicinal Chemistry Letters, 2012, Zhu, Peng et. al.
Synthesis, and cytotoxic activity of some novel indolo[2,3- b]quinoline derivatives
score: 1.9850266, Bioorganic & Medicinal Chemistry, 1999, Kaczmarek, et. al.
Syntheses of Novel Diphenyl Piperazine Derivatives and Their Activities as Inhibitors of Dopamine Uptake in the Central Nervous System
score: 1.984856, Bioorganic & Medicinal Chemistry, 2003, Kimura, Makoto et. al.
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors
score: 1.9847433, Bioorganic & Medicinal Chemistry, 2006, Woods, Keith W. et. al.
Nitrophenyl Derivatives as Aldose Reductase Inhibitors
score: 1.9847139, Bioorganic & Medicinal Chemistry, 2002, Costantino, Luca et. al.
Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide
score: 1.9843546, Bioorganic & Medicinal Chemistry, 2006, Parkkari, Teija et. al.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
score: 1.9842992, Bioorganic & Medicinal Chemistry Letters, 2012, Rudd, Michael T. et. al.
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose.
score: 1.9837389, Antimicrobial agents and chemotherapy, 2001, Ma, Y et. al.
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease
score: 1.9835598, Bioorganic & Medicinal Chemistry Letters, 2012, Sunose, Mihiro et. al.
Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists
score: 1.9830647, Bioorganic & Medicinal Chemistry, 2012, Negoro, Kenji et. al.
Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides
score: 1.9830036, Bioorganic & Medicinal Chemistry, 2004, Epperson, James R. et. al.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.9824281, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.9824281, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Potential synergism and inhibitors to multiple target enzymes of Xuefu Zhuyu Decoction in cardiac disease therapeutics: A computational approach
score: 1.9822791, Bioorganic & Medicinal Chemistry Letters, 2007, Huang, Qin; Qiao, Xuebin; Xu, Xiaojie
Synthesis of N-(β- D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-β- D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase
score: 1.9822024, Bioorganic & Medicinal Chemistry, 2004, Györgydeák, Zoltán et. al.
Synthesis and antimicrobial activities of structurally novel S,S’-bis(hetero-substituted) disulfides
score: 1.9820151, Bioorganic & Medicinal Chemistry Letters, 2012, Ramaraju, Praveen et. al.
Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression
score: 1.9820131, Bioorganic & Medicinal Chemistry, 2013, Holland, Jason P. et. al.
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
score: 1.981265, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Mo et. al.
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
score: 1.981265, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Mo et. al.
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
score: 1.9811823, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
score: 1.9811823, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction
score: 1.9811823, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3-D QSAR methods
score: 1.9811719, Bioorganic & Medicinal Chemistry, 2002, Sippl, Wolfgang
Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents
score: 1.9810643, Bioorganic & Medicinal Chemistry Letters, 2012, Bai, Kai-Kai et. al.
Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase
score: 1.9809594, Bioorganic & Medicinal Chemistry Letters, 2010, Gupta, Pawan et. al.
Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines † † See ref. 1.
score: 1.980874, Bioorganic & Medicinal Chemistry, 2002, Ng, Howard P. et. al.
Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor
score: 1.9806539, Bioorganic & Medicinal Chemistry Letters, 2004, Kim, Dae-Kee; Kim, Joonseop; Park, Hyun-Ju
Synthesis and structure–activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1)
score: 1.9806405, Bioorganic & Medicinal Chemistry Letters, 2012, Shreder, Kevin R. et. al.
Synthesis and structure–activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1)
score: 1.9806405, Bioorganic & Medicinal Chemistry Letters, 2012, Shreder, Kevin R. et. al.
Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor
score: 1.9804196, Bioorganic & Medicinal Chemistry Letters, 2012, Haddad, Terra et. al.
A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles
score: 1.9802503, European Journal of Medicinal Chemistry, 2012, Almansour, Abdulrahman I. et. al.
A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles
score: 1.9802503, European Journal of Medicinal Chemistry, 2012, Almansour, Abdulrahman I. et. al.
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity
score: 1.9802007, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity
score: 1.9802007, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity
score: 1.9802007, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: Synthesis, DNA binding and cytotoxicity studies
score: 1.980183, Bioorganic & Medicinal Chemistry, 1997, Brooks, Natalie et. al.
Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: Synthesis, DNA binding and cytotoxicity studies
score: 1.980183, Bioorganic & Medicinal Chemistry, 1997, Brooks, Natalie et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain
score: 1.9792227, Bioorganic & Medicinal Chemistry Letters, 2012, Nagase, Hiroshi et. al.
AMBER force field implementation of the boronate function to simulate the inhibition of β-lactamases by alkyl and aryl boronic acids
score: 1.9792097, European Journal of Medicinal Chemistry, 2005, Tafi, Andrea et. al.
Molecular docking and 3-D-QSAR studies on the possible antimalarial mechanism of artemisinin analogues
score: 1.9790787, Bioorganic & Medicinal Chemistry, 2002, Cheng, Feng et. al.
Design and Optimization of Novel (2S,4S,5S)-5-Amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as Renin Inhibitors
score: 1.9790047, Bioorganic & Medicinal Chemistry Letters, 2012, Nakamura, Yuji et. al.
Synthesis and evaluation of diazine containing bioisosteres of (−)-ferruginine as ligands for nicotinic acetylcholine receptors
score: 1.9787291, Bioorganic & Medicinal Chemistry, 2001, Gündisch, Daniela et. al.
Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives
score: 1.9784605, Bioorganic & Medicinal Chemistry, 2005, Hisamichi, Hiroyuki et. al.
Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates
score: 1.9778788, Bioorganic & Medicinal Chemistry, 2006, Zhao, Ming et. al.
Carbonic anhydrase inhibitors: Binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties
score: 1.9776931, Bioorganic & Medicinal Chemistry Letters, 2007, Fiore, Anna Di et. al.
Seven-membered cycloplatinated complexes as a new family of anticancer agents. X-ray characterization and preliminary biological studies
score: 1.9774463, European Journal of Medicinal Chemistry, 2012, Cortés, Roldán et. al.
Identification of novel muscarinic M 3 selective antagonists with a conformationally restricted Hyp-Pro spacer
score: 1.9774152, Bioorganic & Medicinal Chemistry Letters, 2003, Sagara, Yufu et. al.
6-acylamino-2-[(ethylsulfonyl)oxy]-1 H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity
score: 1.9768889, Bioorganic & Medicinal Chemistry, 2001, Vagnoni, Lisa M.; Gronostaj, Michael; Kerrigan, John E.
A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
score: 1.9761929, European Journal of Medicinal Chemistry, 2012, Venkateswararao, Eeda et. al.
3D-QSAR analysis of sialyltransferase inhibitors
score: 1.9761668, Bioorganic & Medicinal Chemistry, 2003, Wang, Xiaofang et. al.
InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents
score: 1.9760747, Bioorganic & Medicinal Chemistry Letters, 2012, Mulakayala, Naveen et. al.
Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids
score: 1.9760724, Bioorganic & Medicinal Chemistry, 2003, de Candia, Modesto et. al.
Design of potent inhibitors for Schistosoma japonica glutathione S-transferase
score: 1.9753302, Bioorganic & Medicinal Chemistry, 2006, Jao, Shu-Chuan; Chen, Jessica; Yang, Kelvin; Li, Wen-Shan
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents
score: 1.9753285, Bioorganic & Medicinal Chemistry, 2006, Dupeyre, Grégory et. al.
Synthesis, antiplatelet activity and comparative molecular field analysis of substituted 2-amino-4 H-pyrido[1,2- a]pyrimidin-4-ones, their congeners and isosteric analogues
score: 1.9750792, Bioorganic & Medicinal Chemistry, 2000, Roma, Giorgio et. al.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
score: 1.9740616, European Journal of Medicinal Chemistry, 2012, Opsenica, Igor et. al.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
score: 1.9740616, European Journal of Medicinal Chemistry, 2012, Opsenica, Igor et. al.
Synthesis and antitumor activity of water-soluble enediyne compounds related to dynemicin a
score: 1.9728959, Bioorganic & Medicinal Chemistry, 1997, Unno, Ryoichi et. al.
The optimization of pyridazinone series of glucan synthase inhibitors
score: 1.9718729, Bioorganic & Medicinal Chemistry Letters, 2012, Kuang, Rongze et. al.
Sulfone and phosphinic acid analogs of decaprenolphosphoarabinose as potential anti-tuberculosis agents
score: 1.9717771, Bioorganic & Medicinal Chemistry, 2004, Centrone, Charla A.; Lowary, Todd L.
Design, synthesis and evaluation of carbazole derivatives as PPARα/γ dual agonists and antioxidants
score: 1.9713962, Bioorganic & Medicinal Chemistry, 2005, Kumar, Rakesh et. al.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.9706843, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase
score: 1.97022, Bioorganic & Medicinal Chemistry, 2012, Luniwal, Amarjit et. al.
Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase
score: 1.97022, Bioorganic & Medicinal Chemistry, 2012, Luniwal, Amarjit et. al.
Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase
score: 1.97022, Bioorganic & Medicinal Chemistry, 2012, Luniwal, Amarjit et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity
score: 1.9694268, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity
score: 1.9690603, Bioorganic & Medicinal Chemistry Letters, 2012, Jakopović, Ivana Palej et. al.
Benzoheterocyclic Amodiaquine Analogues with Potent Antiplasmodial Activity: Synthesis and Pharmacological Evaluation
score: 1.9683325, Bioorganic & Medicinal Chemistry Letters, 2012, Ongarora, Dennis S.B. et. al.
Lead optimization of 4,4 biaryl piperidine amides as γ-secretase inhibitors
score: 1.9681064, Bioorganic & Medicinal Chemistry Letters, 2012, Close, Joshua et. al.
A multidetachable sulfamate linker successfully used in a solid-Phase strategy to generate libraries of sulfamate and phenol derivatives
score: 1.967398, Bioorganic & Medicinal Chemistry Letters, 2002, Poirier, Donald; Ciobanu, Liviu C.; Bérubé, Marie
Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties
score: 1.9673567, Bioorganic & Medicinal Chemistry, 2012, Ballatore, Carlo et. al.
Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system
score: 1.9672893, Bioorganic & Medicinal Chemistry, 2006, Hwang, Der-Ren et. al.
Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333
score: 1.9669193, Bioorganic & Medicinal Chemistry Letters, 2012, Beinat, Corinne et. al.
Thalidomide analogues demonstrate dual inhibition of both angiogenesis and prostate cancer
score: 1.966874, Bioorganic & Medicinal Chemistry, 2004, Capitosti, Scott M; Hansen, Todd P; Brown, Milton L
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies.
score: 1.9667289, Antimicrobial agents and chemotherapy, 2006, Tasdemir, Deniz et. al.
3D-QSAR study of sulfonamide inhibitors of human carbonic anhydrase II
score: 1.9665477, European Journal of Medicinal Chemistry, 2007, Huang, Huoqiang et. al.
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.9664666, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.9664666, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.9664666, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Synthesis and biological evaluation of novel carbon-11-labelled analogues of citalopram as potential radioligands for the serotonin transporter
score: 1.9664422, Bioorganic & Medicinal Chemistry, 2003, Madsen, Jacob et. al.
Cytotoxicities, cell cycle and caspase evaluations of 1,6-diaryl-3( Z)-hexen-1,5-diynes, 2-(6-aryl-3( Z)-hexen-1,5-diynyl)anilines and their derivatives
score: 1.9662272, Bioorganic & Medicinal Chemistry, 2005, Lin, Chi-Fong et. al.
Design, synthesis, and evaluation of new type of l-amino acids containing pyridine moiety as nitric oxide synthase inhibitor
score: 1.9661622, Bioorganic & Medicinal Chemistry, 2006, Ijuin, Ryosuke; Umezawa, Naoki; Higuchi, Tsunehiko
Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy
score: 1.966055, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Ming et. al.
Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases
score: 1.9651594, Bioorganic & Medicinal Chemistry, 2004, Su, Xiangdong et. al.
Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents
score: 1.9651552, Bioorganic & Medicinal Chemistry Letters, 2012, Avupati, Vasudeva Rao et. al.
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
score: 1.9650876, European Journal of Medicinal Chemistry, 2012, Bargiotti, Alberto et. al.
Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists
score: 1.9649454, Bioorganic & Medicinal Chemistry Letters, 2004, Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Pyrazole CCK 1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free–Wilson additivity
score: 1.9646797, Bioorganic & Medicinal Chemistry Letters, 2006, Sehon, Clark et. al.
Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor
score: 1.9645758, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Heng et. al.
Synthesis of indolizidinone analogues of cytotoxic alkaloids: Monocyclic precursors are also active
score: 1.9641032, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Synthesis of indolizidinone analogues of cytotoxic alkaloids: Monocyclic precursors are also active
score: 1.9641032, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Synthesis of indolizidinone analogues of cytotoxic alkaloids: Monocyclic precursors are also active
score: 1.9641032, Bioorganic & Medicinal Chemistry Letters, 2012, Boto, Alicia; Miguélez, Javier; Marín, Raquel; Díaz, Mario
Identification of benzoxazole analogs as novel, S1P3 sparring S1P1 agonists
score: 1.9639793, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors
score: 1.9634315, Bioorganic & Medicinal Chemistry, 2005, Chen, Qiao-Hong; Rao, P.N. Praveen; Knaus, Edward E.
QSAR and 3D-QSAR of phenothiazine type multidrug resistance modulators in P388/ADR cells
score: 1.9631451, Bioorganic & Medicinal Chemistry, 2003, Tsakovska, Ivanka M.
N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators
score: 1.9620402, Bioorganic & Medicinal Chemistry Letters, 2012, Packiarajan, Mathivanan et. al.
Preparation and biological properties of biotinylated PhTX derivatives
score: 1.9615303, Bioorganic & Medicinal Chemistry, 1999, Hashimoto, Masaru et. al.
Structure–activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia
score: 1.9612238, Bioorganic & Medicinal Chemistry, 2012, Fushimi, Nobuhiko et. al.
Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptor
score: 1.9609253, Bioorganic & Medicinal Chemistry Letters, 2005, Pontillo, Joseph et. al.
Anti-human immunodeficiency virus activities of nucleosides and nucleotides: correlation with molecular electrostatic potential data.
score: 1.9607148, Antimicrobial agents and chemotherapy, 2000, Mickle, T; Nair, V
Fragment Informatics and Computational Fragment-Based Drug Design: An Overview and Update.
score: 1.9603748, Medicinal research reviews, 2012, Sheng, Chunquan; Zhang, Wannian
Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies
score: 1.9602722, Bioorganic & Medicinal Chemistry Letters, 2013, Butini, Stefania et. al.
Studies on 3′-quaternary ammonium cephalosporins—III. Synthesis and antibacterial activity of 3′-(3-aminopyrazolium)cephalosporins
score: 1.9598028, Bioorganic & Medicinal Chemistry, 1997, Ohki, Hidenori et. al.
Symmetrical Approach of Spiro-pyrazolidinediones as Acetyl-CoA Carboxylase Inhibitors
score: 1.9596588, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI
score: 1.9596111, Bioorganic & Medicinal Chemistry, 2003, Mayoral, Elena P. et. al.
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors
score: 1.9593714, European Journal of Medicinal Chemistry, 2012, Giraud, Francis et. al.
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors
score: 1.9593714, European Journal of Medicinal Chemistry, 2012, Giraud, Francis et. al.
Synthesis and structure–activity relationships of thioflavone derivatives as specific inhibitors of the ERK-MAP kinase signaling pathway
score: 1.9591853, Bioorganic & Medicinal Chemistry, 2004, Kataoka, Tadashi et. al.
Synthesis and evaluation of a series of 1,4-Diarylbutadienes for anticoccidial activity
score: 1.9586465, Bioorganic & Medicinal Chemistry, 2003, Gage, Jennifer L et. al.
Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities
score: 1.958548, Bioorganic & Medicinal Chemistry, 1997, O'Sullivan, Mary C. et. al.
Synthesis and antitumor activity of novel 10-substituted camptothecin analogues
score: 1.958531, Bioorganic & Medicinal Chemistry, 2006, Li, Qingyong et. al.
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases
score: 1.9584126, Bioorganic & Medicinal Chemistry Letters, 2012, Curtin, Michael L. et. al.
Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties
score: 1.9583092, Bioorganic & Medicinal Chemistry, 2012, Ballatore, Carlo et. al.
2-D and 3-D modeling of imidazoline receptor ligands: Insights into pharmacophore
score: 1.9582503, Bioorganic & Medicinal Chemistry, 1997, Carrieri, A. et. al.
Synthesis and evaluation of analogues of congo red as potential compounds against transmissible spongiform encephalopathies
score: 1.9580165, European Journal of Medicinal Chemistry, 2003, Rudyk, Hélène et. al.
Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide
score: 1.9571976, Bioorganic & Medicinal Chemistry, 2005, Terracciano, Stefania et. al.
Synthesis of Paclitaxel–BGL Conjugates
score: 1.9570321, Bioorganic & Medicinal Chemistry, 2012, Nemoto, Hisao et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.9570041, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.9570041, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.9570041, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter
score: 1.9565796, Bioorganic & Medicinal Chemistry, 2005, Zea-Ponce, Yolanda et. al.
Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors
score: 1.956195, Bioorganic & Medicinal Chemistry, 2004, O'Neill, David J. et. al.
Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
score: 1.9561192, Bioorganic & Medicinal Chemistry Letters, 2012, Khan, Mohammad Faheem et. al.
Inhibition of the complete set of mammalian secreted phospholipases A 2 by indole analogues
score: 1.956069, Bioorganic & Medicinal Chemistry, 2004, Smart, Brian P. et. al.
Dopamine-selective potentiometric responses by new ditopic sensory elements based on a hexahomotrioxacalix[3]arene
score: 1.9554494, Bioorganic & Medicinal Chemistry Letters, 2007, Saijo, Ryosuke et. al.
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR)
score: 1.955142, Bioorganic & Medicinal Chemistry, 2013, Orlandi, Francesca et. al.
in vitro inhibition of the measles virus by novel ring-expanded (‘fat’) nucleoside analogues containing the imidazo[4,5- e] [1,3]diazepine ring system
score: 1.9548515, Bioorganic & Medicinal Chemistry Letters, 2002, Zhang, Ning et. al.
HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides
score: 1.9547287, Bioorganic & Medicinal Chemistry Letters, 2012, St. Laurent, Denis R. et. al.
Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
score: 1.9545278, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Guo Hua et. al.
Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
score: 1.9545278, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Guo Hua et. al.
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules
score: 1.9544411, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules
score: 1.9544411, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules
score: 1.9544411, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
Structure–activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors
score: 1.9544035, Bioorganic & Medicinal Chemistry Letters, 2012, Pajouhesh, Hassan et. al.
Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities
score: 1.9542383, Bioorganic & Medicinal Chemistry, 2012, Shinada, Masashi et. al.
Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors
score: 1.954153, Bioorganic & Medicinal Chemistry, 2005, Franchetti, Palmarisa et. al.
Use of libraries to access new chemical space: applications to CRTH2
score: 1.9539202, Bioorganic & Medicinal Chemistry Letters, 2012, Abid Masood, M. et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.9537544, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.9537544, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.9537544, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
Anticancer activities of novel chalcone and bis-chalcone derivatives
score: 1.953669, Bioorganic & Medicinal Chemistry, 2006, Modzelewska, Aneta et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.9535787, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.9535787, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.9535787, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
score: 1.953332, Bioorganic & Medicinal Chemistry, 2005, Hu, Yonghan et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.9532351, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.9532351, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.9532351, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3 H)-quinazolinone analogs
score: 1.9532258, Bioorganic & Medicinal Chemistry, 2006, Al-Rashood, Sarah T. et. al.
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides
score: 1.9528884, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiaozhuo et. al.
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides
score: 1.9528884, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiaozhuo et. al.
Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy
score: 1.9528114, Bioorganic & Medicinal Chemistry, 2005, Hay, Michael P.; Wilson, William R.; Denny, William A.
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
score: 1.9524902, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
score: 1.9524902, European Journal of Medicinal Chemistry, 2012, Rao, Vidadala Ramasubba et. al.
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists
score: 1.9522816, Bioorganic & Medicinal Chemistry Letters, 2012, Poslusney, Michael S. et. al.
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists
score: 1.9522816, Bioorganic & Medicinal Chemistry Letters, 2012, Poslusney, Michael S. et. al.
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists
score: 1.9522816, Bioorganic & Medicinal Chemistry Letters, 2012, Poslusney, Michael S. et. al.
Antiproliferative activity of new 1-aryl-4-amino-1 H-pyrazolo[3,4- d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line
score: 1.9520358, European Journal of Medicinal Chemistry, 2004, Schenone, Silvia et. al.
Molecular modeling analysis of the interaction of novel bis-cationic ligands with the lipid A moiety of lipopolysaccharide
score: 1.9518929, Bioorganic & Medicinal Chemistry Letters, 2006, Guo, Jian-Xin et. al.
Investigation of Beckett–Casy model 3: Synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology
score: 1.9515874, Bioorganic & Medicinal Chemistry Letters, 2010, Nagase, Hiroshi et. al.
Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities
score: 1.9513565, Bioorganic & Medicinal Chemistry, 2002, Miki, Takashi et. al.
Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases
score: 1.9507137, Bioorganic & Medicinal Chemistry, 2012, Bhabak, Krishna P.; Arenz, Christoph
Synthesis and cytotoxic activities of analogues of thuriferic acid
score: 1.9507058, Bioorganic & Medicinal Chemistry, 2002, Madrigal, Blanca et. al.
Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N 1, N 4-dioxide derivatives by complexation with vanadium
score: 1.9499779, Bioorganic & Medicinal Chemistry, 2006, Urquiola, Carolina et. al.
Flavonoids and cinnamic acid esters as inhibitors of fungal 17β-hydroxysteroid dehydrogenase: A synthesis, QSAR and modelling study
score: 1.9496814, Bioorganic & Medicinal Chemistry, 2006, Sova, Matej et. al.
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3)
score: 1.949629, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Essa et. al.
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3)
score: 1.949629, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Essa et. al.
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3)
score: 1.949629, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Essa et. al.
α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4
score: 1.9495279, Bioorganic & Medicinal Chemistry, 2012, Lemonnier, Gérald et. al.
Synthesis, DNA cleavage, and cytotoxicity of a series of bis(propargylic) sulfone crown ethers
score: 1.9493424, Bioorganic & Medicinal Chemistry, 2001, McPhee, Mark M.; Kerwin, Sean M.
Inhibitors of theYersiniaprotein tyrosine phosphatase through high throughput and virtual screening approaches
score: 1.9492831, Bioorganic & Medicinal Chemistry Letters, 2013, Hu, Xin; Vujanac, Milos; Southall, Noel; Erec Stebbins, C.
Synthesis of Constrained Benzocinnolinone Analogues of CEP-26401 (Irdabisant) as Potent, Selective Histamine H3 Receptor Inverse Agonists
score: 1.9492809, Bioorganic & Medicinal Chemistry Letters, 2012, Josef, Kurt A. et. al.
A new facile chemoenzymatic synthesis of levamisole
score: 1.9489266, Bioorganic & Medicinal Chemistry Letters, 2005, Kamal, Ahmed; Khanna, G.B. Ramesh; Krishnaji, T.; Ramu, R.
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
score: 1.94857, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Betty et. al.
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
score: 1.94857, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Betty et. al.
Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis
score: 1.9480946, Bioorganic & Medicinal Chemistry, 2012, Petch, Donna et. al.
Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure–anti-mycobacterial activities
score: 1.9472863, Bioorganic & Medicinal Chemistry, 2005, Macaev, Fliur et. al.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
score: 1.947213, Bioorganic & Medicinal Chemistry Letters, 2012, McGowan, David et. al.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
score: 1.947213, Bioorganic & Medicinal Chemistry Letters, 2012, McGowan, David et. al.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
score: 1.947213, Bioorganic & Medicinal Chemistry Letters, 2012, McGowan, David et. al.
Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes
score: 1.9471114, Bioorganic & Medicinal Chemistry Letters, 2012, Du, Xiaohui et. al.
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors
score: 1.9464963, European Journal of Medicinal Chemistry, 2012, Gu, Shuang-Xi et. al.
Facile and efficient approach for the synthesis of N 2-dimethylaminomethylene-2′- O-methylguanosine
score: 1.9461391, Bioorganic & Medicinal Chemistry Letters, 2010, Mukobata, Tsuyoshi et. al.
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors
score: 1.946049, European Journal of Medicinal Chemistry, 2012, Ribone, Sergio R. et. al.
High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries
score: 1.9455202, Bioorganic & Medicinal Chemistry Letters, 2010, Buller, Fabian et. al.
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
score: 1.9448577, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
score: 1.9448577, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
Identification of novel inhibitors of bacterial translation elongation factors.
score: 1.9446511, Antimicrobial agents and chemotherapy, 2005, Jayasekera, Maithri M K et. al.
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
score: 1.9443472, Bioorganic & Medicinal Chemistry Letters, 2012, Verma, Vishal A. et. al.
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
score: 1.9443472, Bioorganic & Medicinal Chemistry Letters, 2012, Verma, Vishal A. et. al.
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
score: 1.9443472, Bioorganic & Medicinal Chemistry Letters, 2012, Verma, Vishal A. et. al.
Synthesis and in vitro antitumor activity of novel series 2-benzylthio-4-chlorobenzenesulfonamide derivatives
score: 1.9443062, European Journal of Medicinal Chemistry, 2006, Sławiński, J.; Brzozowski, Z.
Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs
score: 1.9442995, Bioorganic & Medicinal Chemistry Letters, 2013, Xu, Libo et. al.
Development of prostaglandin D 2 receptor antagonist: discovery of highly potent antagonists
score: 1.9437493, Bioorganic & Medicinal Chemistry, 2004, Torisu, Kazuhiko et. al.
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode
score: 1.9436699, Bioorganic & Medicinal Chemistry Letters, 2006, von Geldern, Thomas W. et. al.
Chlamydocin–hydroxamic acid analogues as histone deacetylase inhibitors
score: 1.9436236, Bioorganic & Medicinal Chemistry, 2004, Nishino, Norikazu et. al.
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives
score: 1.9435085, Bioorganic & Medicinal Chemistry Letters, 2012, Akué-Gédu, Rufine et. al.
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives
score: 1.9435085, Bioorganic & Medicinal Chemistry Letters, 2012, Akué-Gédu, Rufine et. al.
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives
score: 1.9435085, Bioorganic & Medicinal Chemistry Letters, 2012, Akué-Gédu, Rufine et. al.
Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors
score: 1.9430335, Bioorganic & Medicinal Chemistry, 2005, Jin, Yi et. al.
Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives
score: 1.942843, European Journal of Medicinal Chemistry, 2012, Audisio, Davide et. al.
Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development
score: 1.9427493, Bioorganic & Medicinal Chemistry Letters, 2012, Raboisson, Patrick et. al.
Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development
score: 1.9427493, Bioorganic & Medicinal Chemistry Letters, 2012, Raboisson, Patrick et. al.
Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of type 3 17β-hydroxysteroid dehydrogenase
score: 1.9426037, Bioorganic & Medicinal Chemistry, 2001, Maltais, René; Luu-The, Van; Poirier, Donald
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis.
score: 1.9424336, Antimicrobial agents and chemotherapy, 2010, Nare, Bakela et. al.
An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines
score: 1.9423993, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines
score: 1.9423993, Bioorganic & Medicinal Chemistry Letters, 2012, Parmar, Narsidas J. et. al.
Concise and efficient asymmetric synthesis of ( S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ
score: 1.9421955, Bioorganic & Medicinal Chemistry Letters, 2006, Kasuga, Jun-ichi; Hashimoto, Yuichi; Miyachi, Hiroyuki
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
score: 1.9419899, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Junxing et. al.
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
score: 1.9419899, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Junxing et. al.
Docking and 3D-QSAR studies of 7-hydroxycoumarin derivatives as CK2 inhibitors
score: 1.9419816, European Journal of Medicinal Chemistry, 2010, Zhang, Na; Zhong, Rugang
Synthesis and structure–activity relationship for new series of 4-Phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase
score: 1.9419791, Bioorganic & Medicinal Chemistry, 2003, Kubo, Kazuo et. al.
Optically active antifungal azoles: synthesis and antifungal activity of (2 R,3 S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl}-tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol
score: 1.9419724, Bioorganic & Medicinal Chemistry, 2004, Upadhayaya, Ram Shankar et. al.
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor
score: 1.9418686, Bioorganic & Medicinal Chemistry Letters, 2012, Hwang, Jong Yeon et. al.
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds
score: 1.9408956, Bioorganic & Medicinal Chemistry Letters, 2012, Ortar, Giorgio et. al.
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds
score: 1.9408956, Bioorganic & Medicinal Chemistry Letters, 2012, Ortar, Giorgio et. al.
2-Aryl-8-chloro-1,2,4-triazolo[1,5- a]quinoxalin-4-amines as highly potent A 1 and A 3 adenosine receptor antagonists
score: 1.9405596, Bioorganic & Medicinal Chemistry, 2005, Catarzi, Daniela et. al.
Identification of a buried pocket for potent and selective inhibition of Chk1: Prediction and verification
score: 1.9403498, Bioorganic & Medicinal Chemistry, 2006, Foloppe, Nicolas et. al.
Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability
score: 1.9391233, Bioorganic & Medicinal Chemistry, 2004, Ano, Rieko et. al.
Phosphatase inhibitors—III. Benzylaminophosphonic acids as potent inhibitors of human prostatic acid phosphatase
score: 1.9391233, Bioorganic & Medicinal Chemistry, 1996, Beers, Scott A. et. al.
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
score: 1.9386943, Bioorganic & Medicinal Chemistry Letters, 2012, Oza, Vibha et. al.
Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents
score: 1.9385852, Bioorganic & Medicinal Chemistry Letters, 2012, Pandey, Rishi Ranjan et. al.
Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists
score: 1.9384637, Bioorganic & Medicinal Chemistry, 2012, Puleo, Letizia et. al.
Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein
score: 1.9381469, Bioorganic & Medicinal Chemistry, 2013, Peuchmaur, Marine et. al.
Structure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leads.
score: 1.9378642, Antimicrobial agents and chemotherapy, 2006, Joska, Tammy M; Anderson, Amy C
Chemistry and clinical biology of the bryostatins
score: 1.9374716, Bioorganic & Medicinal Chemistry, 2000, Mutter, Roger; Wills, Martin
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.9371891, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.9371891, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
Structure guided P1’ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s Disease
score: 1.937026, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.
score: 1.9368618, Nature chemical biology, 2012, Richter, Lars et. al.
4-Substituted boro-proline dipeptides: Synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities
score: 1.9367007, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Wengen et. al.
New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: Synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies
score: 1.9364273, European Journal of Medicinal Chemistry, 2012, Hanna, Mona M.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles
score: 1.936305, European Journal of Medicinal Chemistry, 2012, Peng, Wei et. al.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles
score: 1.936305, European Journal of Medicinal Chemistry, 2012, Peng, Wei et. al.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles
score: 1.936305, European Journal of Medicinal Chemistry, 2012, Peng, Wei et. al.
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation
score: 1.9362219, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yanhui; Voak, Andrew; Wilkinson, Shane R.; Hu, Longqin
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation
score: 1.9362219, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yanhui; Voak, Andrew; Wilkinson, Shane R.; Hu, Longqin
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
score: 1.9358579, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria
score: 1.9357364, Bioorganic & Medicinal Chemistry, 2012, Cherian, Philip T. et. al.
Synthesis and biological evaluation of new spin-labeled derivatives of podophyllotoxin
score: 1.9355908, Bioorganic & Medicinal Chemistry, 2006, Jin, Yan; Chen, Shi-Wu; Tian, Xuan
Design, synthesis and biological evaluation of 6-substituted carboxamido benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists
score: 1.9354494, Bioorganic & Medicinal Chemistry, 2012, Zhang, Jun et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 1.9353938, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay.
score: 1.9342502, Antimicrobial agents and chemotherapy, 2012, Yu, Xuemei et. al.
Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists
score: 1.934238, Bioorganic & Medicinal Chemistry, 2012, Zhang, Jun et. al.
Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation
score: 1.9340864, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation
score: 1.9340864, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Synthesis and structure activity relationship of guanidines as NPY Y5 antagonists
score: 1.9338385, Bioorganic & Medicinal Chemistry, 2004, Aquino, Christopher J et. al.
Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents
score: 1.9338279, Bioorganic & Medicinal Chemistry Letters, 2012, Husain, Asif et. al.
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV
score: 1.9335068, Bioorganic & Medicinal Chemistry Letters, 2012, Manchester, John I. et. al.
Insertion of an internal dipeptide into PNA oligomers: Thermal melting studies and further functionalization
score: 1.9334842, Bioorganic & Medicinal Chemistry Letters, 2006, Kersebohm, Tim; Kirin, Srec̀ko I.; Metzler-Nolte, Nils
Synthesis and structure–activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure
score: 1.9334522, Bioorganic & Medicinal Chemistry, 2005, Kuramochi, Takahiro et. al.
Fused Tricyclic Indoles as S1P1 Agonists with Robust Efficacy in Animal Models of Autoimmune Disease
score: 1.9334104, Bioorganic & Medicinal Chemistry Letters, 2012, Buzard, Daniel et. al.
Synthesis of alkenyldiarylmethane (ADAM) non-Nucleoside HIV-1 reverse transcriptase inhibitors with non-Identical aromatic rings
score: 1.9333652, Bioorganic & Medicinal Chemistry, 2002, Xu, Guozhang et. al.
Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors
score: 1.9332086, Bioorganic & Medicinal Chemistry, 2006, Zhang, Li; Zhang, Jie; Fang, Hao; Wang, Qiang; Xu, Wenfang
Synthesis of a novel tetrahydroisoquinolino[2,1- c][1,4]benzodiazepine ring system with DNA recognition potential
score: 1.9331356, Bioorganic & Medicinal Chemistry Letters, 2004, Kothakonda, Kiran Kumar; Bose, D. Subhas
Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors
score: 1.9329245, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Dong-Dong et. al.
A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes
score: 1.932847, Bioorganic & Medicinal Chemistry Letters, 2012, Graham, Thomas H. et. al.
Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors
score: 1.9325677, Bioorganic & Medicinal Chemistry Letters, 2013, Luo, Yin et. al.
High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3- c]quinolin-3-ones
score: 1.9323153, Bioorganic & Medicinal Chemistry, 2003, Carotti, Andrea et. al.
Synthesis and nematocide activity of S-glycopyranosyl-6,7-diarylthiolumazines
score: 1.9322723, Bioorganic & Medicinal Chemistry, 2004, Martins Alho, Miriam A et. al.
N-Acyl- N-alkyl-sulfonamide anchors derived from Kenner’s safety-catch linker: powerful tools in bioorganic and medicinal chemistry
score: 1.9321818, Bioorganic & Medicinal Chemistry, 2005, Heidler, Philipp; Link, Andreas
Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship
score: 1.9321773, Bioorganic & Medicinal Chemistry Letters, 2012, Kers, Inger et. al.
Design and synthesis of downsized metastin (45–54) analogs with maintenance of high GPR54 agonistic activity
score: 1.9320747, Bioorganic & Medicinal Chemistry Letters, 2006, Niida, Ayumu et. al.
Synthesis and antimicrobial activity of tetrodecamycin partial structures
score: 1.9316787, Bioorganic & Medicinal Chemistry, 2003, Paintner, Franz F et. al.
A brief tour of myxobacterial secondary metabolism
score: 1.9316182, Bioorganic & Medicinal Chemistry, 2009, Weissman, Kira J.; Müller, Rolf
Amino substituted derivatives of 5′-amino-5′-deoxy-5′-noraristeromycin
score: 1.931593, Bioorganic & Medicinal Chemistry, 2005, Yang, Minmin; Schneller, Stewart W.
Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists
score: 1.9313296, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Chuangxing et. al.
Towards a Kcc2 Blocker Pharmacophore Model
score: 1.9310868, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.931073, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents
score: 1.9309296, Bioorganic & Medicinal Chemistry, 1996, ter Haar, Ernst et. al.
Discovery of Novel Phosphonic Acid Derivatives as New Chemical Leads for Inhibitors of TNF-α production
score: 1.9308217, Bioorganic & Medicinal Chemistry, 2002, Matsui, Toshiaki et. al.
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors
score: 1.9305881, Bioorganic & Medicinal Chemistry Letters, 2012, Pechulis, Anthony D. et. al.
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors
score: 1.9305881, Bioorganic & Medicinal Chemistry Letters, 2012, Pechulis, Anthony D. et. al.
Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase
score: 1.9305646, Bioorganic & Medicinal Chemistry Letters, 2012, Heasley, Brian H. et. al.
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC
score: 1.9305388, Bioorganic & Medicinal Chemistry Letters, 2012, Warmus, Joseph S. et. al.
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies
score: 1.9301594, Bioorganic & Medicinal Chemistry Letters, 2012, Watanabe, Yoshikazu et. al.
Structure-Activity Relationships and Key Structural Feature of Pyridyloxybenzene-Acylsulfonamides as New, Potent, and Selective Peroxisome Proliferator-Activated Receptor (PPAR) γ Agonists
score: 1.9300873, Bioorganic & Medicinal Chemistry, 2012, Rikimaru, Kentaro et. al.
The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phenyl]-(3-methyl-but-2-enyl)-amine, an N-type Ca +2 channel blocker with oral activity for analgesia
score: 1.9299587, Bioorganic & Medicinal Chemistry, 2000, Hu, Lain-Yen et. al.
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors
score: 1.929727, Bioorganic & Medicinal Chemistry Letters, 2012, Le Brazidec, Jean-Yves et. al.
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors
score: 1.929727, Bioorganic & Medicinal Chemistry Letters, 2012, Le Brazidec, Jean-Yves et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors
score: 1.9296802, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors
score: 1.9296802, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L.
score: 1.9291457, Bioorganic & Medicinal Chemistry Letters, 2012, Sun, Jieyin et. al.
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
score: 1.9291094, Bioorganic & Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
score: 1.9291094, Bioorganic & Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
score: 1.9291094, Bioorganic & Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 1.9286597, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 1.9286597, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity
score: 1.9286348, Bioorganic & Medicinal Chemistry, 2006, Pudhom, Khanitha et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.9285955, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.9285955, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.9285758, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.9285758, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
QSAR studies on piperazinylalkylisoxazole analogues selectively acting on dopamine d 3 receptor by HQSAR and CoMFA
score: 1.9285092, Bioorganic & Medicinal Chemistry, 2003, Cha, Mi Young et. al.
Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling
score: 1.9283698, Bioorganic & Medicinal Chemistry, 2007, Shao, Xuan et. al.
New Substituted 4H-Chromenes as anti-cancer agents
score: 1.9281035, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
Synthesis and biological activity of 22-iodo- and ( E)-20(22)-dehydro analogues of 1α,25-dihydroxyvitamin D 3
score: 1.9277038, Bioorganic & Medicinal Chemistry, 1999, Sicinski, Rafal R.; DeLuca, Hector F.
Synthesis, antiproliferative, and vasorelaxing evaluations of coumarin α-methylene-γ-butyrolactones
score: 1.9273787, Bioorganic & Medicinal Chemistry, 2005, Chen, Yeh-Long et. al.
Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3- d]pyrimidines
score: 1.9272656, European Journal of Medicinal Chemistry, 2003, Donkor, Isaac O; Li, Hui; Queener, Sherry F
Discovery of novel dihydroimidazothiazole derivatives as p53–MDM2 protein–protein interaction inhibitors: Synthesis, biological evaluation and structure–activity relationships
score: 1.9270355, Bioorganic & Medicinal Chemistry Letters, 2012, Miyazaki, Masaki et. al.
Site-Selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings
score: 1.9264066, Bioorganic & Medicinal Chemistry Letters, 2006, Liu, Dan; Zhou, Jiang; Li, Huihui; Zheng, Bo; Yuan, Gu
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.9259968, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
score: 1.9255236, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
score: 1.9255236, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors
score: 1.9255236, Bioorganic & Medicinal Chemistry Letters, 2012, Forsyth, Timothy et. al.
Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives
score: 1.9254806, Bioorganic & Medicinal Chemistry, 2006, Zou, Hong Bin et. al.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.9251684, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.9251684, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.9251684, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
score: 1.9251644, Bioorganic & Medicinal Chemistry, 2012, Choomuenwai, Vanida; Andrews, Katherine T.; Davis, Rohan A.
Identification of specific features of inhibition of PKCβII and its potential lead by shape-based virtual screening and molecular docking studies
score: 1.9246964, Bioorganic & Medicinal Chemistry Letters, 2012, Grewal, Baljinder K.; Elizabeth Sobhia, M.
Highly potent cell differentiation-inducing analogues of 1α,25-dihydroxyvitamin D 3: synthesis and biological activity of 2-methyl-1,25-dihydroxyvitamin D 3 with side-chain modifications
score: 1.9246566, Bioorganic & Medicinal Chemistry, 2001, Fujishima, Toshie et. al.
Synthesis and biological evaluation of 6-aryl-6 H-pyrrolo[3,4- d]pyridazine derivatives as high-affinity ligands of the α 2δ subunit of voltage-gated calcium channels
score: 1.924522, Bioorganic & Medicinal Chemistry Letters, 2004, Hu, Tao et. al.
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.9244274, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.9244274, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.9244274, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Investigation into the structure–activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists
score: 1.9243519, Bioorganic & Medicinal Chemistry, 2005, McCalmont, William F. et. al.
Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4- c]quinoline-1,3-diones
score: 1.9241499, European Journal of Medicinal Chemistry, 2005, Kravchenko, Dmitri V. et. al.
Novobiocin analogues with second-generation noviose surrogates
score: 1.9241077, Bioorganic & Medicinal Chemistry Letters, 2013, Zhao, Huiping; Blagg, Brian S.J.
Biscoumarin: new class of urease inhibitors; economical synthesis and activity
score: 1.9240349, Bioorganic & Medicinal Chemistry, 2004, Khan, Khalid Mohammed et. al.
Synthesis and characterization of 2’-C-Me branched C-nucleosides as HCV polymerase inhibitors
score: 1.9237272, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Oral delivery of G protein-coupled receptor modulators: An explanation for the observed class difference
score: 1.9234518, Bioorganic & Medicinal Chemistry Letters, 2005, Beaumont, Kevin; Schmid, Esther; Smith, Dennis A.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.9234003, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent
score: 1.923327, Bioorganic & Medicinal Chemistry, 2012, Walls, Thomas H. et. al.
Effect of alkyl chain length on sphingosine kinase 2 selectivity
score: 1.9230987, Bioorganic & Medicinal Chemistry Letters, 2012, Knott, Kenneth et. al.
Investigation of the incidence of “undesirable” molecular moieties for high-throughput screening compound libraries in marketed drug compounds
score: 1.9230382, European Journal of Medicinal Chemistry, 2009, Axerio-Cilies, Peter et. al.
Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent
score: 1.9222568, Bioorganic & Medicinal Chemistry Letters, 2012, Odan, Masahide et. al.
The 3-D QSAR study of anticancer 1- N-substituted imidazo- and pyrrolo-quinoline-4,9-dione derivatives by CoMFA and CoMSIA
score: 1.9220834, Bioorganic & Medicinal Chemistry, 2001, Suh, Myung-Eun; Kang, Min-Jung; Park, So-Young
Synthesis and evaluation of novel potent HCV NS5A inhibitors
score: 1.9218723, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hongwang et. al.
Synthesis and evaluation of novel potent HCV NS5A inhibitors
score: 1.9218723, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hongwang et. al.
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity
score: 1.921834, Bioorganic & Medicinal Chemistry Letters, 2012, Fisher, Matthew J. et. al.
Serendipity in discovery of proteasome inhibitors
score: 1.9218234, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Serendipity in discovery of proteasome inhibitors
score: 1.9218234, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Optimization of unique, uncharged thioesters as inhibitors of HIV replication
score: 1.9217806, Bioorganic & Medicinal Chemistry, 2004, Srivastava, Pratibha et. al.
E297G Mutated Bile Salt Export Pump (BSEP) Function Enhancers Derived from GW4064: Structural Development Study and Separation from Farnesoid X Receptor-Agonistic Activity
score: 1.9214702, Bioorganic & Medicinal Chemistry Letters, 2012, Misawa, Takashi et. al.
Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT 4 receptor antagonists
score: 1.9213088, Bioorganic & Medicinal Chemistry, 1999, López-Rodrı́guez, Marı́a L. et. al.
Design and Synthesis of Polyethylene Glycol-modified Biphenylsulfonyl-thiophene-carboxamidine Inhibitors of the Complement Component C1s
score: 1.9212261, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems
score: 1.920692, Bioorganic & Medicinal Chemistry Letters, 2007, Dang, Vinh et. al.
9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase 1
score: 1.9206413, Bioorganic & Medicinal Chemistry Letters, 2002, Brakta, Mohamed et. al.
Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor
score: 1.9205325, Bioorganic & Medicinal Chemistry Letters, 2012, Strachan, Jon-Paul et. al.
Antimalarial activity: A QSAR modeling using CODESSA PRO software
score: 1.9205089, Bioorganic & Medicinal Chemistry, 2006, Katritzky, Alan R. et. al.
Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazolidinones] as potent antifungal agents and crystal structure of spiro[3 H -indole-3,2′-thiazolidine]-3′(1,2,4-triazol-3-yl)-2,4′(1 H )-dione
score: 1.9203665, Bioorganic & Medicinal Chemistry, 2006, Dandia, Anshu et. al.
16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: Synthesis, biological evaluation and in silico probe of ligand–receptor interaction
score: 1.9200648, European Journal of Medicinal Chemistry, 2012, Hu, Hao et. al.
16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: Synthesis, biological evaluation and in silico probe of ligand–receptor interaction
score: 1.9200648, European Journal of Medicinal Chemistry, 2012, Hu, Hao et. al.
Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease
score: 1.9198178, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease
score: 1.9198178, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease
score: 1.9198178, Bioorganic & Medicinal Chemistry Letters, 2012, Monenschein, Holger et. al.
The 3D-QSAR analysis of 4(3 H)-quinazolinone derivatives with dithiocarbamate side chains on thymidylate synthase
score: 1.9197823, Bioorganic & Medicinal Chemistry, 2006, Liu, Shiying et. al.
Design and synthesis of novel metalloproteinase inhibitors
score: 1.9196387, Bioorganic & Medicinal Chemistry, 2006, Nakatani, Shingo et. al.
From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
score: 1.9195864, Bioorganic & Medicinal Chemistry Letters, 2013, Futatsugi, Kentaro et. al.
Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1 H-benzimidazole bioisosteres
score: 1.919533, European Journal of Medicinal Chemistry, 2006, Navarrete-Vázquez, Gabriel et. al.
β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study
score: 1.9194626, Bioorganic & Medicinal Chemistry, 2006, Milhazes, Nuno et. al.
Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors
score: 1.9191244, Bioorganic & Medicinal Chemistry, 2006, Bouissane, L. et. al.
Synthesis of [12]aneN3–dipeptide conjugates as metal-free DNA nucleases
score: 1.9190588, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Zhi-Fen; Chen, Hua-Long; Zhang, Li-Jun; Lu, Zhong-Lin
Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection.
score: 1.9187772, Antimicrobial agents and chemotherapy, 2012, St-Pierre, Christian et. al.
Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors
score: 1.9186225, Bioorganic & Medicinal Chemistry, 2012, Zhan, Wenhu et. al.
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells
score: 1.9185526, Bioorganic & Medicinal Chemistry, 2012, Rennhack, Andreas et. al.
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells
score: 1.9185526, Bioorganic & Medicinal Chemistry, 2012, Rennhack, Andreas et. al.
Synthesis and pharmacological evaluationof 2,3-dihydro-3-oxo-4 H -thieno[3,4- e ][1,2,4]thiadiazine 1,1-dioxidesas voltage-dependent calcium channel blockers
score: 1.9185411, European Journal of Medicinal Chemistry, 2000, Arranz, Esther et. al.
Syntheses and Structure-activity Relationship Studies of N-Substituted-β-D-glucosaminides as Selective Cytotoxic Agents
score: 1.9177579, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Bo et. al.
Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity
score: 1.9173192, Bioorganic & Medicinal Chemistry, 1999, Boyd, Steven A et. al.
Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone
score: 1.9172889, Bioorganic & Medicinal Chemistry, 2013, Szkaradek, Natalia et. al.
The oxetane conformational lock of paclitaxel: Structural analysis of D-secopaclitaxel
score: 1.9171211, Bioorganic & Medicinal Chemistry Letters, 1999, Boge, Thomas C. et. al.
Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: A lipophilic substitute role
score: 1.916962, Bioorganic & Medicinal Chemistry Letters, 2013, Lo, Chih-Yu et. al.
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent
score: 1.91672, Bioorganic & Medicinal Chemistry, 2005, Suzuki, Takayoshi et. al.
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones—Targeting virulence of uropathogenic E. coli
score: 1.9166825, Bioorganic & Medicinal Chemistry, 2006, Åberg, Veronica et. al.
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors
score: 1.9164011, Bioorganic & Medicinal Chemistry, 2012, Albrecht, Sébastien et. al.
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
score: 1.9163714, Bioorganic & Medicinal Chemistry Letters, 2012, Rice, Kenneth D. et. al.
Synthesis, spectral studies and in vitro assessment for antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones
score: 1.9161862, Bioorganic & Medicinal Chemistry Letters, 2005, Singh, Shailendra; Athar, Fareeda; Azam, Amir
Synthesis and antimycobacterial activities of ring-substituted quinolinecarboxylic acid/ester analogues. Part 1
score: 1.9158581, Bioorganic & Medicinal Chemistry, 2004, Vaitilingam, Balasubramanian et. al.
QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release
score: 1.9157532, Bioorganic & Medicinal Chemistry, 2006, Zheng, Fang et. al.
Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in vivo
score: 1.9156413, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Nian-Guang et. al.
Antimalarial activity of N 6-substituted adenosine derivatives. Part 3
score: 1.9154026, Bioorganic & Medicinal Chemistry, 2004, Herforth, Claudia et. al.
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2
score: 1.9153971, European Journal of Medicinal Chemistry, 2012, Galli, Ubaldina et. al.
Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors
score: 1.9151709, Bioorganic & Medicinal Chemistry, 2005, Tait, Annalisa et. al.
Discovery of Novel 5-(Ethyl or hydroxymethyl) Analogs of 2’-“Up” Fluoro (or hydroxyl) Pyrimidine Nucleosides as a New Class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium Inhibitors
score: 1.9150672, Bioorganic & Medicinal Chemistry, 2012, Shakya, Neeraj et. al.
Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs
score: 1.9148037, Bioorganic & Medicinal Chemistry, 2005, Bernier, Stéphane et. al.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.9147948, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 1.9147491, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 1.9147491, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
score: 1.9147491, Bioorganic & Medicinal Chemistry Letters, 2012, Tremblay, Martin et. al.
A novel structural class of potent inhibitors of NF-κB activation: structure–activity relationships and biological effects of 6-aminoquinazoline derivatives
score: 1.9146842, Bioorganic & Medicinal Chemistry, 2003, Tobe, Masanori et. al.
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
score: 1.914523, Bioorganic & Medicinal Chemistry Letters, 2012, Rice, Kenneth D. et. al.
Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives
score: 1.9143688, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Zhigang; Shi, Zhichuan; Liu, Min; Liu, Xingli
Constructing plasma protein binding model based on a combination of cluster analysis and 4D-fingerprint molecular similarity analyses
score: 1.9143657, Bioorganic & Medicinal Chemistry, 2006, Liu, Jianzhong et. al.
Synthesis and evaluation of 2-amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine esters as potential prodrugs of acyclovir
score: 1.9143027, Bioorganic & Medicinal Chemistry, 1998, Kim, Dae-Kee et. al.
Discovery of Pyrazole Carboxylic Acids as Potent Inhibitors of Rat Long Chain L-2-Hydroxy Acid Oxidase
score: 1.9142905, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents
score: 1.9142805, European Journal of Medicinal Chemistry, 2013, Azizmohammadi, Mohammad et. al.
Synthesis and in vitro evaluation of 1,8-diazaanthraquinones bearing 3-dialkylaminomethyl or 3-( N-alkyl- or N-aryl)carbamoyloxymethyl substituent
score: 1.9142481, European Journal of Medicinal Chemistry, 2003, Lee, Heesoon et. al.
Glabracins A and B, two new acetogenins from Annona glabra
score: 1.9141176, Bioorganic & Medicinal Chemistry, 1998, Liu, Xiao-Xi et. al.
Potent inhibitors of CDK5 derived from roscovitine: Synthesis, biological evaluation and molecular modelling
score: 1.9136382, Bioorganic & Medicinal Chemistry Letters, 2013, Demange, Luc et. al.
Isoprenyl-thiourea and urea derivatives as new farnesyl diphospate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities
score: 1.9134506, European Journal of Medicinal Chemistry, 2012, Vega-Pérez, José M. et. al.
Substituted acrylophenones and related mannich bases as possible spermicides and inhibitors of HIV envelope glycoprotein–CD4 interaction
score: 1.9130035, European Journal of Medicinal Chemistry, 2002, Kumaria, Niharika et. al.
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists
score: 1.9129037, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4
score: 1.9128627, Bioorganic & Medicinal Chemistry, 2012, Lemonnier, Gérald et. al.
Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes
score: 1.9122583, Bioorganic & Medicinal Chemistry, 2005, Welch, Karen T. et. al.
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues
score: 1.912255, Bioorganic & Medicinal Chemistry Letters, 2012, Kamal, Ahmed et. al.
Design, synthesis and anticonvulsant activities of novel 1-(substituted/ unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives
score: 1.911995, Bioorganic & Medicinal Chemistry Letters, 2012, Saravanan, Govindaraj et. al.
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors
score: 1.9119292, European Journal of Medicinal Chemistry, 2013, Desideri, Nicoletta et. al.
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors
score: 1.9119292, European Journal of Medicinal Chemistry, 2013, Desideri, Nicoletta et. al.
Kappa agonist CovX-Bodies
score: 1.9117574, Bioorganic & Medicinal Chemistry Letters, 2012, Roberts, Lee R. et. al.
Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity
score: 1.9115227, Bioorganic & Medicinal Chemistry Letters, 2012, Dudkin, Vadim Y. et. al.
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds
score: 1.910988, Bioorganic & Medicinal Chemistry Letters, 2012, Ortar, Giorgio et. al.
Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
score: 1.9109481, Bioorganic & Medicinal Chemistry Letters, 2012, Khan, Mohammad Faheem et. al.
Pyrazolo-[1,5- a]-1,3,5-triazine corticotropin-Releasing factor (CRF) receptor ligands
score: 1.9106709, Bioorganic & Medicinal Chemistry, 2003, Gilligan, Paul J et. al.
α,α-Difluoro-β-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B
score: 1.9106155, Bioorganic & Medicinal Chemistry Letters, 2004, Li, Xianfeng et. al.
Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: Comparison with two original compounds, OL-92 and JP104
score: 1.9105326, Bioorganic & Medicinal Chemistry Letters, 2006, Michaux, Catherine et. al.
Simple Isoquinoline and Benzylisoquinoline Alkaloids as Potential Antimicrobial, Antimalarial, Cytotoxic, and Anti-HIV Agents
score: 1.9101232, Bioorganic & Medicinal Chemistry, 2001, Iwasa, Kinuko et. al.
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
score: 1.910002, Bioorganic & Medicinal Chemistry, 2005, Zheng, Guangrong et. al.
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I
score: 1.9099724, Bioorganic & Medicinal Chemistry Letters, 2012, Valeur, Eric et. al.
In vitro evaluation of synthetic heparin-like conjugates comprising different thrombin binding domains
score: 1.9099392, Bioorganic & Medicinal Chemistry Letters, 1998, Basten, J.E.M. et. al.
Synthesis of functionalized biphenyl- C-nucleosides and their incorporation into oligodeoxynucleotides
score: 1.909701, Bioorganic & Medicinal Chemistry, 2006, Zahn, Alain; Leumann, Christian J.
Highly potent inhibitors of TNF-α production. Part I
score: 1.909656, Bioorganic & Medicinal Chemistry, 2002, Matsui, Toshiaki et. al.
Synthesis of Novel Analogues of Marine Indole Alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and Bis(indolyl)-4-trifluoromethylpyridines as Potential Anticancer Agents
score: 1.9094858, Bioorganic & Medicinal Chemistry, 2001, Xiong, Wen-Nan; Yang, Cai-Guang; Jiang, Biao
Novel estrogen receptor (ER) modulators: Carbamate and thiocarbamate derivatives with m-carborane bisphenol structure
score: 1.9094332, Bioorganic & Medicinal Chemistry, 2009, Ohta, Kiminori et. al.
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
score: 1.9093684, European Journal of Medicinal Chemistry, 2012, Catto, Marco et. al.
Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di- O-(−)-camphanoyl-(+)- cis-khellactone (7-thia-DCK) analogs
score: 1.9087351, Bioorganic & Medicinal Chemistry, 2004, Chen, Ying et. al.
Doing the methylene shuffle – further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine
score: 1.9069747, European Journal of Medicinal Chemistry, 2012, Abualhasan, Murad N. et. al.
Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA
score: 1.9069158, Bioorganic & Medicinal Chemistry Letters, 2004, Maddaford, Shawn P. et. al.
Discovery and Evaluation of Selective N-type Calcium Channel Blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic Acid Derivatives
score: 1.9066946, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
score: 1.9064492, Bioorganic & Medicinal Chemistry Letters, 2000, Kappe, C.Oliver
Synthesis of chemoreversible prodrugs of ara-C with variable time-release profiles. Biological evaluation of their apoptotic activity
score: 1.9062036, Bioorganic & Medicinal Chemistry, 1996, Wipf, Peter et. al.
Further optimization of sulfonamide analogs as EP1 receptor antagonists: Synthesis and evaluation of bioisosteres for the carboxylic acid group
score: 1.9059861, Bioorganic & Medicinal Chemistry, 2006, Naganawa, Atsushi et. al.
Explorations into modeling human oral bioavailability
score: 1.9059849, European Journal of Medicinal Chemistry, 2008, Wang, Zhi; Yan, Aixia; Yuan, Qipeng; Gasteiger, Johann
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold
score: 1.9050967, Bioorganic & Medicinal Chemistry, 2006, Yue, Eddy W. et. al.
Ago-allosteric modulators of human glucagon-like peptide 2 receptor
score: 1.9049514, Bioorganic & Medicinal Chemistry Letters, 2012, Yamazaki, Kazuto et. al.
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists
score: 1.9048781, Bioorganic & Medicinal Chemistry Letters, 2012, Cameron, Kimberly O. et. al.
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists
score: 1.9047112, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists
score: 1.9047112, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
Microwave enhanced solid support synthesis of fluorine containing benzopyrano-triazolo-thiadiazepines as potent anti-fungal agents
score: 1.9046014, Bioorganic & Medicinal Chemistry, 2006, Dandia, Anshu; Singh, Ruby; Khaturia, Sarita
Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor
score: 1.9043514, Bioorganic & Medicinal Chemistry Letters, 2012, Strachan, Jon-Paul et. al.
Synthesis and MEK1 inhibitory activities of imido-Substituted 2-chloro-1,4-naphthoquinones
score: 1.904255, Bioorganic & Medicinal Chemistry, 2003, Bakare, Oladapo et. al.
Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors
score: 1.9041835, Bioorganic & Medicinal Chemistry Letters, 2012, Agarwal, Hitesh K. et. al.
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
score: 1.9040488, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xi et. al.
Preparation and antioxidant activity of α-pyridoin and its derivatives
score: 1.9037747, Bioorganic & Medicinal Chemistry, 2005, Hatanaka, Masashi et. al.
An improved synthesis of 5′-fluoro-5′-deoxyadenosines
score: 1.9036923, Bioorganic & Medicinal Chemistry Letters, 2005, Ashton, Trent D.; Scammells, Peter J.
High throughput purification of combinatorial libraries
score: 1.9034303, Bioorganic & Medicinal Chemistry Letters, 1998, Schultz, Lauri et. al.
Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl)thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic
score: 1.9032799, Bioorganic & Medicinal Chemistry Letters, 2012, Popsavin, Mirjana et. al.
Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl)thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic
score: 1.9032799, Bioorganic & Medicinal Chemistry Letters, 2012, Popsavin, Mirjana et. al.
Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
score: 1.9031149, Bioorganic & Medicinal Chemistry Letters, 2012, Midtkandal, Rebecca R. et. al.
Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
score: 1.9024376, Bioorganic & Medicinal Chemistry, 2012, Yoshida, Tomohiro et. al.
N-Substituted amino acid N′-benzylamides: synthesis, anticonvulsant, and metabolic activities
score: 1.902431, Bioorganic & Medicinal Chemistry, 2004, Béguin, Cécile et. al.
Apoptosis-inducing effect of epolactaene derivatives on BALL-1 cells
score: 1.9011765, Bioorganic & Medicinal Chemistry, 2006, Kuramochi, Kouji et. al.
Synthesis and structure–activity relationships of fibrate-based analogues inside PPARs
score: 1.9011364, Bioorganic & Medicinal Chemistry Letters, 2012, Giampietro, Letizia et. al.
Spirohydantoin derivatives of thiopyrano[2,3- b]pyridin-4(4 H)-one as potent in vitro and in vivo aldose reductase inhibitors
score: 1.9008475, Bioorganic & Medicinal Chemistry, 2005, Da Settimo, Federico et. al.
Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives
score: 1.9008187, Bioorganic & Medicinal Chemistry, 2006, Sondhi, Sham M.; Dinodia, Monica; Kumar, Ashok
Syntheses of quinolone hydrochloride enantiomers from synthons ( R)- and ( S)-2-methylpiperazine
score: 1.9006761, Bioorganic & Medicinal Chemistry, 2005, Liu, Bo et. al.
Synthesis and structure–activity relationships of a series of pyrrole cannabinoid receptor agonists
score: 1.9000853, Bioorganic & Medicinal Chemistry, 2003, Tarzia, Giorgio et. al.
Fancy bioisosteres: Synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands
score: 1.8998979, Bioorganic & Medicinal Chemistry, 2005, Lenz, Carola et. al.
Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE
score: 1.8996903, Bioorganic & Medicinal Chemistry, 2001, Yang, Zhixiang et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.899672, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.899672, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.899672, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Synthesis of a novel plant growth promoter from gallic acid
score: 1.8993506, Bioorganic & Medicinal Chemistry Letters, 2005, Negi, Arvind Singh et. al.
Novel glycine transporter type-2 reuptake inhibitors. Part 1: α-amino acid derivatives
score: 1.898836, Bioorganic & Medicinal Chemistry, 2004, Wolin, Ronald L et. al.
design and synthesis of a novel series of HIV-1 protease inhibitors
score: 1.8984202, Bioorganic & Medicinal Chemistry, 1999, Takashiro, Eiji et. al.
Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines
score: 1.898228, Bioorganic & Medicinal Chemistry, 2012, Kouznetsov, Vladimir V. et. al.
Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines
score: 1.898228, Bioorganic & Medicinal Chemistry, 2012, Kouznetsov, Vladimir V. et. al.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8975807, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8975807, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8975807, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.8975459, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.8975459, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.8975459, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
A translation inhibitor that suppresses dengue virus in vitro and in vivo.
score: 1.8974248, Antimicrobial agents and chemotherapy, 2011, Wang, Qing-Yin et. al.
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates
score: 1.8974138, Bioorganic & Medicinal Chemistry, 2000, Kuang, Rongze et. al.
Structure-activity study of estrogenic agonists bearing dicarba- closo-dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules
score: 1.8969172, Bioorganic & Medicinal Chemistry Letters, 1999, Endo, Yasuyuki et. al.
Discovery of P2X3 selective antagonists for the treatment of chronic pain
score: 1.8967041, Bioorganic & Medicinal Chemistry Letters, 2012, Cantin, Louis-David et. al.
Synthesis and in vitro evaluation of α-synuclein ligands
score: 1.8966983, Bioorganic & Medicinal Chemistry, 2012, Yu, Lihai et. al.
3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity
score: 1.8965993, Bioorganic & Medicinal Chemistry, 2006, Athri, Prashanth et. al.
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement
score: 1.8958459, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Antitumor agents—CLXXIII. Synthesis and evaluation of camptothecin-4β-amino-4′- O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents
score: 1.8957778, Bioorganic & Medicinal Chemistry, 1997, Bastow, Kenneth F. et. al.
Antitumor agents—CLXXIII. Synthesis and evaluation of camptothecin-4β-amino-4′- O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents
score: 1.8957778, Bioorganic & Medicinal Chemistry, 1997, Bastow, Kenneth F. et. al.
Sesquiterpene-like inhibitors of a 9- cis-epoxycarotenoid dioxygenase regulating abscisic acid biosynthesis in higher plants
score: 1.8955812, Bioorganic & Medicinal Chemistry, 2009, Boyd, Jason et. al.
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
score: 1.8954948, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Hermogenes N. et. al.
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
score: 1.8954948, Bioorganic & Medicinal Chemistry Letters, 2012, Jimenez, Hermogenes N. et. al.
ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors
score: 1.8951893, Bioorganic & Medicinal Chemistry, 2012, Scholz, Matthias et. al.
ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors
score: 1.8951893, Bioorganic & Medicinal Chemistry, 2012, Scholz, Matthias et. al.
3D-QSAR study of ring-substituted quinoline class of anti-tuberculosis agents
score: 1.8951076, Bioorganic & Medicinal Chemistry, 2006, Nayyar, Amit et. al.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.8948584, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.8948584, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity
score: 1.8947481, Bioorganic & Medicinal Chemistry Letters, 2012, González-Sabín, Javier et. al.
Synthesis and anti-tubercular activity of a series of 2-sulfonamido/trifluoromethyl-6-substituted imidazo[2,1- b]-1,3,4-thiadiazole derivatives
score: 1.8945596, Bioorganic & Medicinal Chemistry, 2004, Gadad, Andanappa K. et. al.
Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden
score: 1.8944231, Bioorganic & Medicinal Chemistry, 2009, Muehlebach, Michel et. al.
Facile synthesis of non-steroidal anti-inflammatory active bisbenzamide-containing compounds
score: 1.8939024, Bioorganic & Medicinal Chemistry, 2006, Girgis, Adel S.; Ellithey, Mohey
Natural products-based insecticidal agents 4. Semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against Mythimna separata Walker in vivo
score: 1.8938653, Bioorganic & Medicinal Chemistry Letters, 2009, Xu, Hui; Xiao, Xiao
Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation
score: 1.893405, European Journal of Medicinal Chemistry, 2012, Abdou, Wafaa M.; Barghash, Reham F.; Sediek, Ashraf A.
Beyond physical properties—Application of Abraham descriptors and LFER analysis in agrochemical research
score: 1.8932101, Bioorganic & Medicinal Chemistry, 2009, Clarke, Eric D
Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls
score: 1.892908, Bioorganic & Medicinal Chemistry, 2012, De Schutter, Joris W. et. al.
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers
score: 1.8929, Bioorganic & Medicinal Chemistry, 2005, Mehanna, Ahmed S.; Kim, Jin Yung
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
score: 1.8926961, European Journal of Medicinal Chemistry, 2012, Zhang, Zhili et. al.
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
score: 1.8926961, European Journal of Medicinal Chemistry, 2012, Zhang, Zhili et. al.
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
score: 1.8926961, European Journal of Medicinal Chemistry, 2012, Zhang, Zhli et. al.
Bile acid-based receptors containing 2,6-bis(acylamino)pyridine for recognition of uracil derivatives
score: 1.8923443, Bioorganic & Medicinal Chemistry Letters, 2007, Chattopadhyay, Prosenjit; Pandey, Pramod S.
Naphthyridinone (NTD) integrase inhibitors: N1 Protio and methyl combination substituent effects with C3 amide groups
score: 1.8923244, Bioorganic & Medicinal Chemistry Letters, 2013, Johns, Brian A. et. al.
Serendipity in Discovery of Proteasome Inhibitors
score: 1.8922655, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors
score: 1.8920759, European Journal of Medicinal Chemistry, 2005, Shen, Qiong et. al.
Synthesis and evaluation of a new series of 1′-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4′-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists
score: 1.8920558, Bioorganic & Medicinal Chemistry Letters, 2012, Dandu, Reddeppa Reddy et. al.
D-ring modified novel isosteviol derivatives: Design, synthesis and cytotoxic activity evaluation
score: 1.8920175, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Tao et. al.
Short pseudopeptides containing turn scaffolds with high AT 2 receptor affinity
score: 1.8918437, Bioorganic & Medicinal Chemistry, 2006, Georgsson, Jennie et. al.
Discovery of oxazole-based PDE4 inhibitors with picomolar potency
score: 1.8914192, Bioorganic & Medicinal Chemistry Letters, 2012, Kuang, Rongze et. al.
Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase.
score: 1.8913286, Antimicrobial agents and chemotherapy, 2004, Ling, Losee L et. al.
Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents
score: 1.8908808, Bioorganic & Medicinal Chemistry, 2012, El Ashry, El Sayed H. et. al.
Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents
score: 1.8908808, Bioorganic & Medicinal Chemistry, 2012, El Ashry, El Sayed H. et. al.
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: The hydrophobic side chain influences type A subtype selectivity
score: 1.8907766, Bioorganic & Medicinal Chemistry, 2012, Li, Yanwu et. al.
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: The hydrophobic side chain influences type A subtype selectivity
score: 1.8907766, Bioorganic & Medicinal Chemistry, 2012, Li, Yanwu et. al.
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands
score: 1.8907765, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands
score: 1.8907765, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Tetra substituted thiophenes as anti-inflammatory agents: Exploitation of analogue-based drug design
score: 1.8907187, Bioorganic & Medicinal Chemistry, 2005, Pillai, Ajay D. et. al.
Viridin analogs derived from steroidal building blocks
score: 1.8906896, Bioorganic & Medicinal Chemistry Letters, 2012, Viswanathan, Kishore et. al.
Viridin analogs derived from steroidal building blocks
score: 1.8906896, Bioorganic & Medicinal Chemistry Letters, 2012, Viswanathan, Kishore et. al.
Viridin analogs derived from steroidal building blocks
score: 1.8906896, Bioorganic & Medicinal Chemistry Letters, 2012, Viswanathan, Kishore et. al.
Atom, atom-type and total molecular linear indices as a promising approach for bioorganic and medicinal chemistry: theoretical and experimental assessment of a novel method for virtual screening and rational design of new lead anthelmintic
score: 1.8905601, Bioorganic & Medicinal Chemistry, 2005, Marrero-Ponce, Yovani et. al.
JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities
score: 1.8904401, Bioorganic & Medicinal Chemistry Letters, 2012, Chorvat, Robert J. et. al.
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and Pharmacokinetic evaluation
score: 1.8899213, Bioorganic & Medicinal Chemistry Letters, 2012, Banerjee, Abhisek et. al.
Design, synthesis and vasodilative activity of tanshinone IIA derivatives
score: 1.8887809, Bioorganic & Medicinal Chemistry Letters, 2012, Bi, Yue-Feng et. al.
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors ofmPGES-1: Use of a conformation-based hypothesis to facilitate compound design
score: 1.8887188, Bioorganic & Medicinal Chemistry Letters, 2013, Walker, Daniel P. et. al.
Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis
score: 1.8886811, Bioorganic & Medicinal Chemistry Letters, 2008, Brouwer, Arwin J. et. al.
Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca 2+ release from sarcoplasmic reticulum of mouse skeletal muscle
score: 1.888425, Bioorganic & Medicinal Chemistry, 2003, Hosoya, Takamitsu et. al.
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities
score: 1.8883927, European Journal of Medicinal Chemistry, 2012, Ye, Deju et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.8872832, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.8872832, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.8872832, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
Metabolic conversion of 24-methyl-Δ 25-cholesterol to 24-methylcholesterol in higher plants
score: 1.8867343, Bioorganic & Medicinal Chemistry, 2006, Takahashi, Kyoko et. al.
Structure–activity relationship study of beta-carboline derivatives as haspin kinase inhibitors
score: 1.8866191, Bioorganic & Medicinal Chemistry Letters, 2012, Cuny, Gregory D. et. al.
Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents
score: 1.8863279, Bioorganic & Medicinal Chemistry, 2005, Agarwal, Anu et. al.
Seven-membered cycloplatinated complexes as a new family of anticancer agents. X-ray characterization and preliminary biological studies
score: 1.8860309, European Journal of Medicinal Chemistry, 2012, Cortés, Roldán et. al.
Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity
score: 1.8857319, Bioorganic & Medicinal Chemistry, 2005, Kim, Eun Jin; Ko, Soo Y.
Ras inhibition via direct Ras binding—is there a path forward?
score: 1.8856937, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Weiru; Fang, Guowei; Rudolph, Joachim
Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8856832, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8856832, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8856832, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Synthesis and comparative evaluation of 4-oxa- and 4-aza-podophyllotoxins as antiproliferative microtubule destabilizing agents
score: 1.8856388, Bioorganic & Medicinal Chemistry Letters, 2012, Chernysheva, Natalia B. et. al.
Design and synthesis of triglyceride analogue biotinylated suicide inhibitors for directed molecular evolution of lipolytic enzymes
score: 1.8855184, Bioorganic & Medicinal Chemistry Letters, 2000, Deussen, H.-J; Danielsen, S; Breinholt, J; Borchert, T.V
Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)- N-phenylacetamide—a potential antileishmanial agent
score: 1.8853322, Bioorganic & Medicinal Chemistry, 2002, Sahu, Niranjan P. et. al.
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
score: 1.88512, Bioorganic & Medicinal Chemistry Letters, 2012, Subasinghe, Nalin L. et. al.
Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors
score: 1.8849022, Bioorganic & Medicinal Chemistry Letters, 2005, Shou, Xiaohong; Miledi, Ricardo; Chamberlin, A. Richard
Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents
score: 1.8847459, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tianwen et. al.
Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents
score: 1.8847459, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tianwen et. al.
Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents
score: 1.8847459, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tianwen et. al.
Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer’s disease
score: 1.8847114, Bioorganic & Medicinal Chemistry Letters, 2012, Watanabe, Hiroyuki et. al.
Syntheses of new substituted triazino tetrahydroisoquinolines and β-carbolines as novel antileishmanial agents 1 1 CDRI Communication No. 6459.
score: 1.8843169, European Journal of Medicinal Chemistry, 2006, Kumar, Arun et. al.
Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D2 partial agonists
score: 1.8837073, Bioorganic & Medicinal Chemistry Letters, 2013, Urbanek, Rebecca A. et. al.
Structure-based design and protein X-ray analysis of a protein kinase inhibitor
score: 1.8835342, Bioorganic & Medicinal Chemistry Letters, 2002, Furet, Pascal et. al.
Structural Modification of an Orally Active Thrombin Inhibitor, LB30057: Replacement of the D-Pocket-binding Naphthyl Moiety
score: 1.8835135, Bioorganic & Medicinal Chemistry, 1998, Lee, Koo et. al.
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1 H)-imines and 1,5,6,7-Tetrahydro-2 H-azepin-2-imines
score: 1.8832531, Bioorganic & Medicinal Chemistry, 2003, Kawanaka, Yasufumi et. al.
Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.8831427, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yu-Shun et. al.
Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.8831427, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yu-Shun et. al.
Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit
score: 1.8829771, Bioorganic & Medicinal Chemistry Letters, 2009, Damljanović, Ivan et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity
score: 1.8819752, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity
score: 1.8819752, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
Synthesis of a novel, recyclable, solid-Phase acylating reagent
score: 1.8817502, Bioorganic & Medicinal Chemistry Letters, 2002, Nicewonger, Robert B. et. al.
Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases
score: 1.8808386, Bioorganic & Medicinal Chemistry, 2002, Peng, Hairuo et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8805972, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives
score: 1.8804079, Bioorganic & Medicinal Chemistry, 2003, Kolokythas, George et. al.
Synthesis, molecular modelling and enzymatic evaluation of (±)3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors
score: 1.8802791, Bioorganic & Medicinal Chemistry, 2006, Gauthier, Marie P. et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8801123, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8801123, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
Linear and cyclic dipeptides with antimalarial activity
score: 1.8801123, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Picaso, Lemuel et. al.
On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans
score: 1.8798536, Bioorganic & Medicinal Chemistry Letters, 2013, Sidhu, Preetpal S. et. al.
Comparative QSAR modeling of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas
score: 1.8797261, Bioorganic & Medicinal Chemistry Letters, 2006, Thomas Leonard, J.; Roy, Kunal
Design, synthesis and in vitro evaluation of ( R)-4-(2-( tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl hydrogen phenylboronate: A novel salbutamol derivative with high intrinsic efficacy on the β 2 adrenoceptor
score: 1.8791263, Bioorganic & Medicinal Chemistry Letters, 2010, Soriano-Ursúa, Marvin A. et. al.
Synthesis of some monocyclic analogues of mycophenolic acid via the Johnson ortho ester Claisen rearrangement
score: 1.878978, Bioorganic & Medicinal Chemistry, 2005, Meza-Aviña, Ma Elena et. al.
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
score: 1.8774125, Bioorganic & Medicinal Chemistry Letters, 2012, Amombo, Ghislaine Marlyse Okala et. al.
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
score: 1.8774125, Bioorganic & Medicinal Chemistry Letters, 2012, Amombo, Ghislaine Marlyse Okala et. al.
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
score: 1.8774125, Bioorganic & Medicinal Chemistry Letters, 2012, Amombo, Ghislaine Marlyse Okala et. al.
“Propylene spaced” allyl tin reagents: A new class of fluorous tin reagents for allylations under radical and metal-catalyzed conditions
score: 1.8773922, Bioorganic & Medicinal Chemistry Letters, 1998, Curran, Dennis P.; Luo, Zhiyong; Degenkolb, Peter
An expedient synthesis of N 6-substituted-5′-modified adenosines
score: 1.8767276, Bioorganic & Medicinal Chemistry Letters, 2006, Ashton, T.D.; Scammells, Peter J.
Molecular modeling of the dopamine D 2 and serotonin 5-HT 1A receptor binding modes of the enantiomers of 5-OMe-BPAT
score: 1.8766695, Bioorganic & Medicinal Chemistry, 1999, Homan, Evert J.; Wikström, Håkan V.; Grol, Cor J.
Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors
score: 1.8766446, Bioorganic & Medicinal Chemistry, 2006, Liu, Yan et. al.
Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity
score: 1.8764217, European Journal of Medicinal Chemistry, 2013, Arya, Surbhi; Kumar, Nikhil; Roy, Partha; Sondhi, S.M.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.87579, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity
score: 1.87579, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Di-Liang et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.8756953, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype
score: 1.8753481, Bioorganic & Medicinal Chemistry, 2012, Calugi, Chiara et. al.
Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype
score: 1.8753481, Bioorganic & Medicinal Chemistry, 2012, Calugi, Chiara et. al.
Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
score: 1.8753248, Bioorganic & Medicinal Chemistry Letters, 2012, Bussenius, Joerg et. al.
Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs
score: 1.8752506, Bioorganic & Medicinal Chemistry, 2005, Våbenø, Jon et. al.
Synthesis and biological evaluation of new tetrahydro-β-carbolines as inhibitors of the mitotic kinesin Eg5
score: 1.875238, Bioorganic & Medicinal Chemistry, 2005, Sunder-Plassmann, Nils et. al.
Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors
score: 1.8751921, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Aixia; Wang, Kai
Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors
score: 1.8751921, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Aixia; Wang, Kai
Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors
score: 1.8751921, Bioorganic & Medicinal Chemistry Letters, 2012, Yan, Aixia; Wang, Kai
Microwave-assisted, one-pot syntheses and fungicidal activity of polyfluorinated 2-benzylthiobenzothiazoles
score: 1.8749295, Bioorganic & Medicinal Chemistry, 2006, Huang, Wei; Yang, Guang-Fu
Solid-phase synthesis of pyrrolo[2,1- c] [1,4]benzodiazepine-5,11-diones
score: 1.8746782, Bioorganic & Medicinal Chemistry Letters, 2001, Kamal, Ahmed; Reddy, G.Suresh Kumar; Raghavan, Sadagopan
Synthesis and activity of 1 H-benzimidazole and 1 H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii
score: 1.874676, Bioorganic & Medicinal Chemistry, 2004, Kopańska (née Zastąpiło), Katarzyna et. al.
Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988
score: 1.8746152, Bioorganic & Medicinal Chemistry, 1996, Augelli-Szafran, Corinne E. et. al.
A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma
score: 1.8740191, Bioorganic & Medicinal Chemistry Letters, 2013, Long, Daniel D. et. al.
Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives
score: 1.8740186, Bioorganic & Medicinal Chemistry Letters, 2012, Serra, Silvia et. al.
An approach to heterobifunctional poly(ethyleneglycol) bioconjugates
score: 1.8740159, Bioorganic & Medicinal Chemistry Letters, 2005, Li, Jane et. al.
Synthesis and biological evaluation of substrate-Based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African Trypanosomiasis
score: 1.873766, Bioorganic & Medicinal Chemistry, 2003, Dardonville, Christophe et. al.
Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin
score: 1.8736618, European Journal of Medicinal Chemistry, 2012, Zhang, Shao-Lin et. al.
A novel two-step QSAR modeling work flow to predict selectivity and activity of HDAC inhibitors
score: 1.8734926, Bioorganic & Medicinal Chemistry Letters, 2013, Zhao, Lingling et. al.
Synthesis and biological evaluation of disubstituted N 6-cyclopentyladenine analogues
score: 1.8734844, Bioorganic & Medicinal Chemistry, 2004, de Ligt, Rianne A.F. et. al.
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation
score: 1.8733858, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier-Dit-Chabert, Jérémie et. al.
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation
score: 1.8733858, Bioorganic & Medicinal Chemistry Letters, 2012, Fournier-Dit-Chabert, Jérémie et. al.
Kinetic model studies on the chemical ligation of oligonucleotides via hydrazone formation
score: 1.8732854, Bioorganic & Medicinal Chemistry Letters, 2005, Achilles, K.; Kiedrowski, G.v.
Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities
score: 1.8731993, Bioorganic & Medicinal Chemistry, 2005, Sondhi, Sham M. et. al.
Identification of 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl]- N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration
score: 1.8725216, Bioorganic & Medicinal Chemistry, 2006, Singh, Sunil Kumar et. al.
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
score: 1.8723625, Bioorganic & Medicinal Chemistry, 2012, Su, Xiangdong et. al.
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
score: 1.8723625, Bioorganic & Medicinal Chemistry, 2012, Su, Xiangdong et. al.
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
score: 1.8723625, Bioorganic & Medicinal Chemistry, 2012, Su, Xiangdong et. al.
Design, synthesis, and BK channel-opening activity of hexahydrodibenzazepinone derivatives
score: 1.8721577, Bioorganic & Medicinal Chemistry, 2006, Tashima, Toshihiko et. al.
Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs
score: 1.8718988, Bioorganic & Medicinal Chemistry, 2006, Marrero-Ponce, Yovani et. al.
On-resin macrocyclization of peptides via intramolecular S nAr reactions
score: 1.8718112, Bioorganic & Medicinal Chemistry Letters, 1999, Fotsch, Christopher et. al.
The design of potent hydrazones and disulfides as cathepsin S inhibitors
score: 1.8717106, Bioorganic & Medicinal Chemistry, 2003, Cywin, Charles L et. al.
Design, synthesis and structure–activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains
score: 1.8715, European Journal of Medicinal Chemistry, 2012, Wang, Shengzheng et. al.
Synthesis and antitumor activity of bicyclo[3.3.1]nonenol derivatives
score: 1.8707354, Bioorganic & Medicinal Chemistry, 2004, Geirsson, Jon K.F.; Jonsson, Stefan; Valgeirsson, Jon
Structure–activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells
score: 1.8706789, Bioorganic & Medicinal Chemistry, 2005, Gibson, Scott L. et. al.
Identification of Novel Drug-Resistant EGFR Mutant Inhibitors by In Silico Screening using Comprehensive Assessments of Protein Structures
score: 1.8706685, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8705999, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
Synthesis of 2-Deoxy-2-C-Alkylglucosides of myo-Inositol as possible inhibitors of a N-Deacetylase enzyme in the biosynthesis of mycothiol
score: 1.8703814, Bioorganic & Medicinal Chemistry Letters, 2003, Gammon, David W. et. al.
Design and synthesis of new antimalarial agents from 4-aminoquinoline
score: 1.8702057, Bioorganic & Medicinal Chemistry, 2005, Solomon, V. Raja et. al.
Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones
score: 1.8699337, Bioorganic & Medicinal Chemistry Letters, 2012, Ryu, Chung-Kyu; Kim, Aram; Im, Hyun Ah; Kim, Ji Young
A concise synthesis of photoactivatable 4-Aroyl- l-phenylalanines
score: 1.8698277, Bioorganic & Medicinal Chemistry Letters, 2000, Morera, Enrico; Ortar, Giorgio
Structure–Activity Relationships of 1β-Methyl-2-(5-phenylpyrrolidin-3-ylthio)carbapenems
score: 1.8696836, Bioorganic & Medicinal Chemistry, 2002, Sato, Hiroki et. al.
Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: A practical access via Pd/C–Cu catalysis
score: 1.8696634, Bioorganic & Medicinal Chemistry Letters, 2012, Gorja, Dhilli Rao et. al.
A Focused Small-Molecule Screen Identifies 14 Compounds with Distinct Effects on Toxoplasma gondii.
score: 1.8694006, Antimicrobial agents and chemotherapy, 2012, Kamau, Edwin T et. al.
Structure-Based design and discovery of novel inhibitors of protein tyrosine phosphatases
score: 1.8692834, Bioorganic & Medicinal Chemistry, 2003, Huang, Ping et. al.
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues
score: 1.8690853, Bioorganic & Medicinal Chemistry, 2012, Wauchope, Orrette R. et. al.
Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides
score: 1.8686802, Bioorganic & Medicinal Chemistry Letters, 2012, Asami, Taiji et. al.
Synthesis and in vitro leishmanicidal activity of 2-(1-methyl-5-nitro-1 H-imidazol-2-yl)-5-substituted-1,3,4-thiadiazole derivatives
score: 1.8684963, European Journal of Medicinal Chemistry, 2005, Foroumadi, Alireza et. al.
New triterpenoid saponins from Cacti and anti-type I allergy activity of saponins from cactus
score: 1.8684684, Bioorganic & Medicinal Chemistry Letters, 2012, Kakuta, Kazutaka et. al.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
score: 1.8681306, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
score: 1.8681306, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
score: 1.8681306, Bioorganic & Medicinal Chemistry, 2012, Sato, Tomohiro et. al.
New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase
score: 1.867932, Bioorganic & Medicinal Chemistry, 2012, Lohou, Elodie et. al.
Structure–activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism
score: 1.867567, Bioorganic & Medicinal Chemistry Letters, 2012, Bhondwe, Rahul S. et. al.
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
score: 1.8673535, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
score: 1.8673535, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity
score: 1.8673239, European Journal of Medicinal Chemistry, 2013, Arya, Surbhi; Kumar, Nikhil; Roy, Partha; Sondhi, S.M.
Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors
score: 1.8669339, Bioorganic & Medicinal Chemistry, 2012, Liu, Jia-Jia et. al.
Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4/ABCC4)
score: 1.8667499, Bioorganic & Medicinal Chemistry Letters, 2008, Ravna, Aina Westrheim; Sager, Georg
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
score: 1.8662807, Bioorganic & Medicinal Chemistry, 2012, Lang, Karen Luise et. al.
Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: Some structural aspects for aldose reductase inhibitory activity and selectivity
score: 1.8655894, Bioorganic & Medicinal Chemistry, 2013, Kotsampasakou, Eleni; Demopoulos, Vassilis J.
Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists
score: 1.8655744, Bioorganic & Medicinal Chemistry, 2006, Cai, Zhefeng et. al.
Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity.
score: 1.8653974, Antimicrobial agents and chemotherapy, 2006, Ponte-Sucre, Alicia et. al.
A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles
score: 1.8652009, European Journal of Medicinal Chemistry, 2012, Almansour, Abdulrahman I. et. al.
Antagonists of the myelin-associated glycoprotein: A new class of tetrasaccharide mimics
score: 1.8650715, Bioorganic & Medicinal Chemistry, 2006, Schwizer, Daniel et. al.
Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives
score: 1.8650229, European Journal of Medicinal Chemistry, 2006, Tan, J.-H. et. al.
Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity
score: 1.864997, European Journal of Medicinal Chemistry, 2013, Liu, Han-Wei et. al.
Water soluble prodrugs of the antitumor agent 3-[(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-one
score: 1.8643459, Bioorganic & Medicinal Chemistry, 2003, Nam, Nguyen-Hai et. al.
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides
score: 1.8642961, Bioorganic & Medicinal Chemistry Letters, 2012, McComas, Casey et. al.
Preparation, antibacterial evaluation and preliminary structure–activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives
score: 1.8642385, Bioorganic & Medicinal Chemistry Letters, 2012, Ouyang, Liang et. al.
Preparation, antibacterial evaluation and preliminary structure–activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives
score: 1.8642385, Bioorganic & Medicinal Chemistry Letters, 2012, Ouyang, Liang et. al.
Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives
score: 1.8641656, Bioorganic & Medicinal Chemistry Letters, 2012, Shelke, Sharad N. et. al.
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B
score: 1.8640987, Bioorganic & Medicinal Chemistry Letters, 2012, Van der Walt, Mietha M. et. al.
Pyrazole CCK 1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free–Wilson additivity
score: 1.8640503, Bioorganic & Medicinal Chemistry Letters, 2006, McClure, Kelly et. al.
2,7-Dihydro-3 H-pyridazino[5,4,3- kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation
score: 1.8639726, Bioorganic & Medicinal Chemistry, 2005, Stefańska, Barbara et. al.
Carbonic anhydrase inhibitors: Two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-α-dithienylethene derivatives
score: 1.8637081, Bioorganic & Medicinal Chemistry Letters, 2009, Vomasta, Daniel et. al.
Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety
score: 1.8636981, Bioorganic & Medicinal Chemistry, 2005, Seto, Masaki et. al.
DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives
score: 1.8634697, Bioorganic & Medicinal Chemistry Letters, 2004, Bürli, Roland W. et. al.
Synthesis of Pacidamycin Analogues via an Ugi-Multicomponent Reaction
score: 1.8633713, Bioorganic & Medicinal Chemistry Letters, 2012, Okamoto, Kazuya et. al.
2-Amidino analogs of glycine–amiloride conjugates: Inhibitors of urokinase-type plasminogen activator
score: 1.8628448, Bioorganic & Medicinal Chemistry Letters, 2012, Massey, Archna P. et. al.
Diels–alder approach to tetralin-based constrained α-amino acid derivatives
score: 1.8627232, Bioorganic & Medicinal Chemistry Letters, 2000, Kotha, Sambasivarao; Ganesh, Thota; Ghosh, Arun Kumar
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator
score: 1.8626176, Bioorganic & Medicinal Chemistry Letters, 2012, Mattmann, Margrith E. et. al.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.8625316, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.8625316, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
score: 1.8625316, Bioorganic & Medicinal Chemistry Letters, 2012, Pfefferkorn, Jeffrey A. et. al.
Design, synthesis, spectral and biological evaluation of novel 1-allyl substituted 2,6-diphenylpiperidin-4-ones and its derivatives of oximes/oxime ethers
score: 1.8624786, Bioorganic & Medicinal Chemistry Letters, 2012, Narayanan, Kuppusamy et. al.
Design, synthesis, spectral and biological evaluation of novel 1-allyl substituted 2,6-diphenylpiperidin-4-ones and its derivatives of oximes/oxime ethers
score: 1.8624786, Bioorganic & Medicinal Chemistry Letters, 2012, Narayanan, Kuppusamy et. al.
Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position
score: 1.8624765, Bioorganic & Medicinal Chemistry, 2004, Ohno, Michihiro et. al.
Cytotoxic activities of novel hexahydroindolizino[8,7-b]indole derivatives prepared by 1,3-dipolar cycloaddition reactions of 3,4-dihydro-β-carboline ylides
score: 1.8624693, Bioorganic & Medicinal Chemistry, 2001, Bertrand, Martial et. al.
Genetic introduction of a diketone-containing amino acid into proteins
score: 1.8624551, Bioorganic & Medicinal Chemistry Letters, 2006, Zeng, Huaqiang; Xie, Jianming; Schultz, Peter G.
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
score: 1.862168, Bioorganic & Medicinal Chemistry, 2012, Aminake, Makoah N. et. al.
Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives
score: 1.8621276, Bioorganic & Medicinal Chemistry, 2005, Chiyanzu, Idan et. al.
Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b
score: 1.8619223, Bioorganic & Medicinal Chemistry, 2004, Garneau, Sylvie et. al.
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors
score: 1.8619048, Bioorganic & Medicinal Chemistry, 2006, Hayakawa, Masahiko et. al.
Doing the methylene shuffle – Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
score: 1.8619036, European Journal of Medicinal Chemistry, 2012, Abualhasan, Murad N. et. al.
Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds
score: 1.8616979, Bioorganic & Medicinal Chemistry, 2003, Delfourne, Evelyne et. al.
A comparative protease stability study of synthetic macrocyclic peptides that mimic two endocrine hormones
score: 1.8616486, Bioorganic & Medicinal Chemistry Letters, 2013, Ferrie, John J. et. al.
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth
score: 1.8615004, Bioorganic & Medicinal Chemistry Letters, 2012, Siiskonen, Antti et. al.
A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4- N-aryl-[1,4] diazepane ureas
score: 1.8611861, European Journal of Medicinal Chemistry, 2009, Afantitis, Antreas et. al.
Design and synthesis of 3-fluoro-2-oxo-3-phenylpropionic acid derivatives as potent inhibitors of 4-hydroxyphenylpyruvate dioxygenase from pig liver
score: 1.8611825, Bioorganic & Medicinal Chemistry, 1999, Ling, Tung-shen; Shiu, Shi; Yang, Ding-yah
Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloroimidazole embodied 4-azafluorenones via molecular hybridization approach
score: 1.861168, Bioorganic & Medicinal Chemistry Letters, 2012, Addla, Dinesh et. al.
Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloroimidazole embodied 4-azafluorenones via molecular hybridization approach
score: 1.861168, Bioorganic & Medicinal Chemistry Letters, 2012, Addla, Dinesh et. al.
Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloroimidazole embodied 4-azafluorenones via molecular hybridization approach
score: 1.861168, Bioorganic & Medicinal Chemistry Letters, 2012, Addla, Dinesh et. al.
Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element
score: 1.8610222, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element
score: 1.8610222, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element
score: 1.8610222, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Discovery of liver selective non-steroidal glucocorticoid receptor antagonist as novel antidiabetic agents
score: 1.8607054, Bioorganic & Medicinal Chemistry Letters, 2012, Shah, Kiran et. al.
Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists
score: 1.860111, Bioorganic & Medicinal Chemistry, 2012, Negoro, Kenji et. al.
Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists
score: 1.860111, Bioorganic & Medicinal Chemistry, 2012, Negoro, Kenji et. al.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry
score: 1.8599769, Bioorganic & Medicinal Chemistry, 2012, Lapinsky, David J.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry
score: 1.8599769, Bioorganic & Medicinal Chemistry, 2012, Lapinsky, David J.
Anthranilic acid derivatives: a new class of non-peptide CCK 1 receptor antagonists
score: 1.8599747, Bioorganic & Medicinal Chemistry, 2003, Varnavas, Antonio et. al.
Discovery of a novel melanin-concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
score: 1.8598366, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B
score: 1.8597925, Bioorganic & Medicinal Chemistry Letters, 2012, Van der Walt, Mietha M. et. al.
Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction
score: 1.8595463, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Young B. et. al.
Synthetic study on the unique dimeric arylpiperazine: access to the minor contaminant of aripiprazole
score: 1.8591812, Bioorganic & Medicinal Chemistry Letters, 2003, Torisawa, Yasuhiro et. al.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
score: 1.8590122, European Journal of Medicinal Chemistry, 2012, Opsenica, Igor et. al.
Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28
score: 1.8583171, Bioorganic & Medicinal Chemistry, 2006, Hulshof, Janneke W. et. al.
Synthesis of daidzin analogues as potential agents for alcohol abuse
score: 1.8582607, Bioorganic & Medicinal Chemistry, 2003, Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines
score: 1.8580055, Bioorganic & Medicinal Chemistry Letters, 2005, Tucci, Fabio C. et. al.
Synthesis and biological evaluation of a technetium-99m(I)-tricarbonyl-labelled phenyltropane derivative
score: 1.8579354, Bioorganic & Medicinal Chemistry Letters, 2006, Kieffer, Davy M. et. al.
The evolution of synthetic oral drug properties
score: 1.8576053, Bioorganic & Medicinal Chemistry Letters, 2005, Proudfoot, John R.
Optimized N-phenyl- N′-(2-chloroethyl)ureas as potential antineoplastic agents: Synthesis and growth inhibition activity
score: 1.8571167, Bioorganic & Medicinal Chemistry, 2005, Moreau, Emmanuel et. al.
Synthesis and in vitro antiproliferative activity of platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane as ligands
score: 1.8562657, European Journal of Medicinal Chemistry, 2012, Sun, Yanyan et. al.
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
score: 1.8560311, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Mo et. al.
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease
score: 1.8560195, European Journal of Medicinal Chemistry, 2012, Hamulakova, Slavka et. al.
The synthesis of novel fluorescent purine analogues modified by azacrown ether at C6
score: 1.8560039, Bioorganic & Medicinal Chemistry Letters, 2010, Guo, Hai-Ming et. al.
Synthesis of 14C-radiolabeled oligonucleotides with a novel phosphoramidite reagent
score: 1.8556917, Bioorganic & Medicinal Chemistry Letters, 1998, Guzaev, Andrei et. al.
Synthesis and biological evaluation of lipophilic Ca 1a 2L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1
score: 1.8556904, Bioorganic & Medicinal Chemistry, 2005, El Oualid, Farid et. al.
Halogenated flavanones as potential apoptosis-inducing agents: synthesis and biological activity evaluation
score: 1.8555431, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1)
score: 1.8555174, Bioorganic & Medicinal Chemistry, 2012, Orchard, Alexandra et. al.
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1)
score: 1.8555174, Bioorganic & Medicinal Chemistry, 2012, Orchard, Alexandra et. al.
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit
score: 1.8549504, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Xianming et. al.
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit
score: 1.8549504, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Xianming et. al.
Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities.
score: 1.854456, Antimicrobial agents and chemotherapy, 2006, Karginov, Vladimir A et. al.
One pot synthesis of thiazolodihydropyrimidinones and evaluation of their anticancer activity
score: 1.8541558, European Journal of Medicinal Chemistry, 2004, Holla, B.Shivarama et. al.
Toward intrinsically fluorescent proteomimetics: Fluorescent probe response to alpha helix structure of poly-γ-benzyl- l-glutamate
score: 1.8538827, Bioorganic & Medicinal Chemistry Letters, 2006, Hutt, Kenji; Hernandez, Randy; Heagy, Michael D.
Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers
score: 1.8535755, Bioorganic & Medicinal Chemistry, 2005, Graulich, A. et. al.
A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
score: 1.8535009, European Journal of Medicinal Chemistry, 2012, Venkateswararao, Eeda et. al.
Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1 H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1 H-pyrazoles
score: 1.8531797, Bioorganic & Medicinal Chemistry, 2004, Menozzi, Giulia et. al.
Synthesis and biological relationships of 3′,6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents
score: 1.8531677, Bioorganic & Medicinal Chemistry, 2005, Lai, Ya-Yun et. al.
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
score: 1.8529017, Bioorganic & Medicinal Chemistry, 2012, Chosson, Elizabeth et. al.
Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl α-ketoamide derivatives containing pyridine moiety
score: 1.8528289, Bioorganic & Medicinal Chemistry, 2006, Shirasaki, Yoshihisa et. al.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
score: 1.8526704, Bioorganic & Medicinal Chemistry Letters, 2012, Tichenor, Mark S. et. al.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
score: 1.8526704, Bioorganic & Medicinal Chemistry Letters, 2012, Tichenor, Mark S. et. al.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
score: 1.8526704, Bioorganic & Medicinal Chemistry Letters, 2012, Tichenor, Mark S. et. al.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption
score: 1.8526065, Bioorganic & Medicinal Chemistry, 2012, Okaniwa, Masanori et. al.
Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa
score: 1.8523921, Bioorganic & Medicinal Chemistry, 1998, Hopp, D.Craig et. al.
Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists
score: 1.8521918, Bioorganic & Medicinal Chemistry Letters, 2012, Lainé, Dramane I. et. al.
Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists
score: 1.8521918, Bioorganic & Medicinal Chemistry Letters, 2012, Lainé, Dramane I. et. al.
Binding of 1-Benzopyran-4-one Derivatives to Aldose Reductase: A Free Energy Perturbation Study
score: 1.851979, Bioorganic & Medicinal Chemistry, 2002, Rastelli, Giulio et. al.
Design and synthesis of potent, orally active, inhibitors of carboxypeptidase U (TAFIa)
score: 1.8518383, Bioorganic & Medicinal Chemistry, 2004, Polla, Magnus O. et. al.
Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity
score: 1.8516957, Bioorganic & Medicinal Chemistry, 2012, Alam, Mohammad Sayed; Choi, Jung-Hyun; Lee, Dong-Ung
Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity
score: 1.8516957, Bioorganic & Medicinal Chemistry, 2012, Alam, Mohammad Sayed; Choi, Jung-Hyun; Lee, Dong-Ung
Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity
score: 1.8516957, Bioorganic & Medicinal Chemistry, 2012, Alam, Mohammad Sayed; Choi, Jung-Hyun; Lee, Dong-Ung
Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents
score: 1.8512264, Bioorganic & Medicinal Chemistry, 2004, Jones, Simon M et. al.
Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy
score: 1.8510056, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Ming et. al.
Structure–activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding
score: 1.8508559, Bioorganic & Medicinal Chemistry, 2004, Lee, Jeewoo et. al.
Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents
score: 1.8506222, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Qian et. al.
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.8504889, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.8504889, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia
score: 1.8504889, Bioorganic & Medicinal Chemistry Letters, 2012, Khanna, Smriti et. al.
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current
score: 1.8502166, Bioorganic & Medicinal Chemistry, 2005, Novella Romanelli, Maria et. al.
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: Design, synthesis, and microbiological evaluation
score: 1.8502093, Bioorganic & Medicinal Chemistry, 2006, Schiaffella, Fausto et. al.
Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution
score: 1.8500603, Bioorganic & Medicinal Chemistry Letters, 2013, Zitko, Jan et. al.
Synthesis and biological evaluation of 6-substituted purine and 9-β- d-ribofuranosyl purine analogues
score: 1.849753, Bioorganic & Medicinal Chemistry, 2004, Wang, Jun-Feng et. al.
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments
score: 1.8497342, Bioorganic & Medicinal Chemistry, 2001, Casimiro-Garcia, Agustin et. al.
Cytotoxic palladium complexes of bioreductive quinoxaline N 1, N 4-dioxide prodrugs
score: 1.8496116, Bioorganic & Medicinal Chemistry, 2009, Urquiola, Carolina et. al.
Structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives
score: 1.8493931, Bioorganic & Medicinal Chemistry, 2005, Guan, Jian et. al.
Adamantyl N-benzylbenzamide: New series of depigmentation agents with tyrosinase inhibitory activity
score: 1.8490711, Bioorganic & Medicinal Chemistry Letters, 2012, Baek, Heung Soo et. al.
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators
score: 1.8490436, Bioorganic & Medicinal Chemistry Letters, 2012, Pettersson, Martin et. al.
Novel glycine transporter type-2 reuptake inhibitors. Part 2: β- and γ-amino acid derivatives
score: 1.8489557, Bioorganic & Medicinal Chemistry, 2004, Wolin, Ronald L et. al.
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1 H-cyclopenta[ b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors
score: 1.8487606, Bioorganic & Medicinal Chemistry, 2006, Rosini, Michela et. al.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
score: 1.8487494, Bioorganic & Medicinal Chemistry Letters, 2012, Wollinsky, Beate et. al.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
score: 1.8487494, Bioorganic & Medicinal Chemistry Letters, 2012, Wollinsky, Beate et. al.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
score: 1.8487494, Bioorganic & Medicinal Chemistry Letters, 2012, Wollinsky, Beate et. al.
Synthesis and comparative molecular field analysis (CoMFA) of argentatin B derivatives as growth inhibitors of human cancer cell lines
score: 1.8486367, Bioorganic & Medicinal Chemistry, 2006, Parra-Delgado, Hortensia et. al.
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
score: 1.8486189, Bioorganic & Medicinal Chemistry, 2006, DeMarco, Steven J. et. al.
Synthesis, cytotoxicity, and anti-inflammatory evaluation of 2-(furan-2-yl)-4-(phenoxy)quinoline derivatives. Part 4
score: 1.848325, Bioorganic & Medicinal Chemistry, 2006, Chen, Yeh-Long et. al.
In silico modeling of protein tyrosine phosphatase 1B inhibitors with cellular activity
score: 1.8481255, Bioorganic & Medicinal Chemistry Letters, 2006, Hu, Xin
Design, synthesis, and biological evaluation of novel 2-pyridinyl-[1,2,4]triazoles as inhibitors of transforming growth factor β1 type 1 receptor
score: 1.847857, Bioorganic & Medicinal Chemistry, 2004, Kim, Dae-Kee; Kim, Joonseop; Park, Hyun-Ju
Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents
score: 1.847802, Bioorganic & Medicinal Chemistry, 2003, Kumar, Ashok et. al.
Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors
score: 1.8476843, Bioorganic & Medicinal Chemistry, 2013, Toti, Kiran S. et. al.
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
score: 1.8476602, European Journal of Medicinal Chemistry, 2012, Ahmed, Nermin S. et. al.
Microwave-assisted synthesis of imidazoles: Reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines
score: 1.84743, Bioorganic & Medicinal Chemistry Letters, 2005, Samanta, Swapan K.; Kylänlahti, Irene; Yli-Kauhaluoma, Jari
Synthesis, structure and biological activity of copper(II) complexes of 4-(2-pyridylmethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione and 4-(2-pyridylethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione
score: 1.8471644, European Journal of Medicinal Chemistry, 2009, Singh, Amit P. et. al.
Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening
score: 1.8468122, Bioorganic & Medicinal Chemistry Letters, 2012, Liang, Guyan et. al.
Radiolytic transformation of rotenone with potential anti-adipogenic activity
score: 1.846618, Bioorganic & Medicinal Chemistry Letters, 2013, Park, Chul-Hong et. al.
Assessing the drug-likeness of lamellarins, a marine-derived natural product class with diverse oncological activities
score: 1.8463687, European Journal of Medicinal Chemistry, 2010, Chittchang, Montakarn et. al.
Selective and potent adenosine A3receptor antagonists by methoxyaryl substitution on theN-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
score: 1.8457264, European Journal of Medicinal Chemistry, 2013, Yaziji, Vicente et. al.
Novel (3,5-di- tert-butyl-2-hydroxy-phenylcarbamoyl)-alkanoic acids as potent antioxidants
score: 1.8455098, Bioorganic & Medicinal Chemistry Letters, 2004, Lodyato, Vladimir I et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides
score: 1.8452453, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties
score: 1.8451944, Bioorganic & Medicinal Chemistry Letters, 1998, Takahashi, Takashi et. al.
Identification of benzoxazole analogs as novel, S1P3 sparing S1P1 agonists
score: 1.8450431, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Identification of benzoxazole analogs as novel, S1P3 sparing S1P1 agonists
score: 1.8450431, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Identification of benzoxazole analogs as novel, S1P3 sparing S1P1 agonists
score: 1.8450431, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Guanghui et. al.
Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile
score: 1.8449635, Bioorganic & Medicinal Chemistry Letters, 2013, Tamura, Yuusuke et. al.
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues
score: 1.8448515, Bioorganic & Medicinal Chemistry, 2012, Wauchope, Orrette R. et. al.
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues
score: 1.8448515, Bioorganic & Medicinal Chemistry, 2012, Wauchope, Orrette R. et. al.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives
score: 1.8447975, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives
score: 1.8447975, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors
score: 1.8444814, Bioorganic & Medicinal Chemistry, 2006, Cossy, Janine et. al.
Investigations of linker structure on the potency of a series of bidentate protein tyrosine phosphatase inhibitors
score: 1.8443509, Bioorganic & Medicinal Chemistry, 2005, Xie, Jian; Seto, Christopher T.
Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs
score: 1.8441305, Bioorganic & Medicinal Chemistry, 2012, Niphakis, Micah J. et. al.
Three-dimensional quantitative structure–activity relationship studies on diverse structural classes of HIV-1 integrase inhibitors using CoMFA and CoMSIA
score: 1.8440899, European Journal of Medicinal Chemistry, 2006, Nunthaboot, Nadtanet et. al.
Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones
score: 1.8437367, Bioorganic & Medicinal Chemistry Letters, 2005, Foroumadi, Alireza et. al.
Macrolactonolides: A novel class of anti-inflammatory compounds
score: 1.8436787, Bioorganic & Medicinal Chemistry, 2013, Tomašković, Linda et. al.
Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques.
score: 1.8435868, Antimicrobial agents and chemotherapy, 2004, Hurdle, Julian Gregston et. al.
Potent histone deacetylase inhibitors: N-hydroxybenzamides with antitumor activities
score: 1.8433295, Bioorganic & Medicinal Chemistry, 2004, Maeda, Taishi et. al.
Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis
score: 1.8433005, Bioorganic & Medicinal Chemistry, 2012, Donald, Michael B. et. al.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
score: 1.8432604, European Journal of Medicinal Chemistry, 2012, Nicolotti, Orazio et. al.
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods
score: 1.8428133, Bioorganic & Medicinal Chemistry Letters, 2006, Aparna, V. et. al.
Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues
score: 1.8423926, Bioorganic & Medicinal Chemistry, 2002, Lima, Lı́dia M et. al.
Fluorine-substituted dihydrobicyclomycins: Synthesis and biochemical and biological properties
score: 1.842247, Bioorganic & Medicinal Chemistry, 2006, Park, Boon-Saeng; Widger, William; Kohn, Harold
Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives
score: 1.8422071, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives
score: 1.8422071, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives
score: 1.8422071, Bioorganic & Medicinal Chemistry Letters, 2012, Yamamoto, Takashi et. al.
Benzofuro[3,2- f][1]benzopyrans: A new class of antitubercular agents
score: 1.8420641, Bioorganic & Medicinal Chemistry, 2006, Prado, Soizic et. al.
Study on molecular mechanism and 3D-QSAR of influenza neuraminidase inhibitors
score: 1.841931, Bioorganic & Medicinal Chemistry, 2003, Yi, Xiang; Guo, Zongru; Chu, Feng Ming
Isomannide derivatives as new class of inhibitors for human kallikrein 7
score: 1.8415975, Bioorganic & Medicinal Chemistry Letters, 2012, Freitas, Renato F. et. al.
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production
score: 1.8411809, Bioorganic & Medicinal Chemistry, 2012, Lee, Bit et. al.
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production
score: 1.8411809, Bioorganic & Medicinal Chemistry, 2012, Lee, Bit et. al.
Design, synthesis, and activity of caffeoyl pyrrolidine derivatives as potential gelatinase inhibitors
score: 1.8411594, Bioorganic & Medicinal Chemistry, 2004, Li, Ya-Lin; Xu, Wen-Fang
Design and Synthesis of Potent Antagonists Containing Rigid Spirocyclic Privileged Structures for the CGRP Receptor
score: 1.8407958, Bioorganic & Medicinal Chemistry Letters, 2012, Chaturvedula, Prasad V. et. al.
Simple synthesis of carbon-11 labeled styryl dyes as new potential PET RNA-specific, living cell imaging probes
score: 1.8406708, European Journal of Medicinal Chemistry, 2009, Wang, Min et. al.
A rationale for the activity profile of benzenesulfonamide derivatives as cyclooxygenase (COX) inhibitors
score: 1.8406399, European Journal of Medicinal Chemistry, 2010, Sharma, Brij Kishore et. al.
Structure-based design of achiral, nonpeptidic hydroxybenzamide as a novel P2/P2′ replacement for the symmetry-based HIV protease inhibitors
score: 1.8406023, Bioorganic & Medicinal Chemistry, 1996, Randad, Ramnarayan S. et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
score: 1.8400344, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
score: 1.8400344, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
score: 1.8400344, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
score: 1.8399587, Bioorganic & Medicinal Chemistry, 2004, Gündisch, Daniela et. al.
Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives
score: 1.8394655, Bioorganic & Medicinal Chemistry, 2004, Koshio, Hiroyuki et. al.
Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors
score: 1.8390134, Bioorganic & Medicinal Chemistry Letters, 2013, Poondra, Rajamohan R. et. al.
Synthesis and biological evaluation of p-carborane bisphenols and their derivatives: Structure–activity relationship for estrogenic activity
score: 1.8388029, Bioorganic & Medicinal Chemistry, 2009, Ogawa, Takumi et. al.
Mechanism-based Design, Synthesis and Biological Studies of N5-Substituted Tetrahydrofolate Analogues as Inhibitors of Cobalamin-dependent Methionine Synthase and Potential Anticancer Agents
score: 1.8378499, European Journal of Medicinal Chemistry, 2012, Zhang, Zhli et. al.
Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.
score: 1.8378033, Antimicrobial agents and chemotherapy, 2002, Evers, David L et. al.
Substituted hexahydrobenzodipyrans as 5-HT 2A/2C receptor probes
score: 1.8374597, Bioorganic & Medicinal Chemistry, 2002, Whiteside, Michael S et. al.
Lysine–spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants
score: 1.8372107, Bioorganic & Medicinal Chemistry, 2005, Burns, Mark R. et. al.
Synthesis and evaluation of 2-Amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-Amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir
score: 1.8367577, Bioorganic & Medicinal Chemistry, 1999, Kim, Dae-Kee et. al.
Synthesis and in vitro study of 17β-[ N-ureylene- N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase
score: 1.836672, Bioorganic & Medicinal Chemistry, 1997, Lourdusamy, Mettilda et. al.
Design and synthesis of new orally active inhibitors of human neutrophil elastase
score: 1.8365987, Bioorganic & Medicinal Chemistry, 2001, Ohmoto, Kazuyuki et. al.
Inhibitors of apoptosis in testicular germ cells: Synthesis and biological evaluation of some novel IBTs bearing sulfonamide moiety
score: 1.8363202, European Journal of Medicinal Chemistry, 2013, Chandak, Navneet et. al.
Inhibitors of apoptosis in testicular germ cells: Synthesis and biological evaluation of some novel IBTs bearing sulfonamide moiety
score: 1.8363202, European Journal of Medicinal Chemistry, 2013, Chandak, Navneet et. al.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
score: 1.8360493, Bioorganic & Medicinal Chemistry, 2012, Chobanian, Harry R. et. al.
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity
score: 1.8359415, Bioorganic & Medicinal Chemistry, 2005, Brun, Marie-Priscille et. al.
Prodrugs for targeting hypoxic tissues: Regiospecific elimination of aspirin from reduced indolequinones
score: 1.8356784, Bioorganic & Medicinal Chemistry Letters, 1999, Jaffar, M et. al.
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[ i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents
score: 1.8353346, Bioorganic & Medicinal Chemistry, 2005, Zhu, Shejin et. al.
Solid- and solution-Phase synthesis of highly-Substituted-Pyrrolidine libraries
score: 1.8353318, Bioorganic & Medicinal Chemistry Letters, 2001, Steger, M; Hubschwerlen, C; Schmid, G
Small molecule tertiary amines as agonists of the nuclear hormone receptor rev-erbα
score: 1.8349576, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Youseung et. al.
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα
score: 1.8349576, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Youseung et. al.
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα
score: 1.8349576, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Youseung et. al.
Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
score: 1.8345664, Bioorganic & Medicinal Chemistry Letters, 2012, Srikanth Reddy, T. et. al.
Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
score: 1.8345664, Bioorganic & Medicinal Chemistry Letters, 2012, Srikanth Reddy, T. et. al.
Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
score: 1.8345664, Bioorganic & Medicinal Chemistry Letters, 2012, Srikanth Reddy, T. et. al.
The synthesis of symmetrical spermine conjugates using solid-phase chemistry
score: 1.8340825, Bioorganic & Medicinal Chemistry Letters, 1998, Page, Patrick et. al.
Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents
score: 1.8338857, Bioorganic & Medicinal Chemistry, 2001, Jiang, Biao; Yang, Cai-Guang; Xiong, Wen-Nan; Wang, Jun
Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates
score: 1.8336468, Bioorganic & Medicinal Chemistry Letters, 2006, Jiang, Xiong-Jie et. al.
Synthesis and antimycobacterial evaluation of certain fluoroquinolone derivatives
score: 1.8335332, Bioorganic & Medicinal Chemistry, 2005, Zhao, Yue-Ling et. al.
Design, synthesis, and evaluation of resveratrol derivatives as Aß1-42 aggregation inhibitors, antioxidants, and neuroprotective agents
score: 1.8332191, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Chuanjun et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides
score: 1.8332044, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides
score: 1.8332044, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Wenxin et. al.
Doing the methylene shuffle – Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
score: 1.8331244, European Journal of Medicinal Chemistry, 2012, Abualhasan, Murad N. et. al.
Neuraminidase pharmacophore model derived from diverse classes of inhibitors
score: 1.8330059, Bioorganic & Medicinal Chemistry Letters, 2006, Zhang, Jian; Yu, KunQian; Zhu, Weiliang; Jiang, Hualiang
Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues
score: 1.8329925, Bioorganic & Medicinal Chemistry, 2001, Kim, Dae-Kee et. al.
iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3( R)-[(2( S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide
score: 1.8326799, Bioorganic & Medicinal Chemistry, 2003, Dolbeare, Kristine et. al.
Synthesis of new phorbol derivatives having ethereal side chain and evaluation of their anti-HIV activity
score: 1.8324753, Bioorganic & Medicinal Chemistry, 2005, Matsuya, Yuji et. al.
An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification
score: 1.8323187, Bioorganic & Medicinal Chemistry Letters, 2004, Dubowchik, Gene M.; Michne, Jodi A.; Zuev, Dmitry
Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012
score: 1.8319602, Bioorganic & Medicinal Chemistry Letters, 2012, Galley, Guido et. al.
Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1 H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors
score: 1.8317504, Bioorganic & Medicinal Chemistry, 2010, Zhang, Li et. al.
Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists
score: 1.8313352, European Journal of Medicinal Chemistry, 2012, Su, Jung-Chen et. al.
Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists
score: 1.8313352, European Journal of Medicinal Chemistry, 2012, Su, Jung-Chen et. al.
Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents
score: 1.8312491, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Qian et. al.
Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents
score: 1.8312491, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Qian et. al.
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors
score: 1.8307147, European Journal of Medicinal Chemistry, 2012, Rajak, Harish et. al.
Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors
score: 1.8304631, Bioorganic & Medicinal Chemistry, 2001, Suzuki, Mikio et. al.
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
score: 1.830344, Bioorganic & Medicinal Chemistry Letters, 2012, Nakamura, Yuji et. al.
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
score: 1.830344, Bioorganic & Medicinal Chemistry Letters, 2012, Nakamura, Yuji et. al.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
score: 1.8301137, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
score: 1.8301137, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
score: 1.8301137, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Solid-phase synthesis of 1,3,4-oxadiazoline-5-thione derivatives from resin-bound acylhydrazines
score: 1.8299123, Bioorganic & Medicinal Chemistry Letters, 2006, Liu, Zhanxiang; Zhao, Jinlong; Huang, Xian
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
score: 1.8298083, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
Exploration of the structure–activity relationship of the diaryl anilide class of ligands for translocator protein—potential novel positron emitting tomography imaging agents
score: 1.8296689, Bioorganic & Medicinal Chemistry Letters, 2012, Wadsworth, Harry et. al.
C–N bond formation under Cu-catalysis: Synthesis and in vitro evaluation of N-aryl substituted thieno[2,3-d]pyrimidin-4(3H)-ones against chorismate mutase
score: 1.8293056, Bioorganic & Medicinal Chemistry, 2012, Adepu, Raju et. al.
Phenolic compounds as antiangiogenic CMG2 inhibitors from costa rican endophytic fungi1
score: 1.8290042, Bioorganic & Medicinal Chemistry Letters, 2012, Cao, Shugeng et. al.
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position
score: 1.8286875, Bioorganic & Medicinal Chemistry Letters, 2012, Hamada, Yoshio et. al.
A Convenient Synthesis and Hepatoprotective Activity of Imidazo[1,2- c]pyrimido[5,4- e]pyrimidine, Tetraazaacenaphthene and Tetraazaphenalene from Cyclic Ketene Aminals Through Tandem Addition-Cyclization Reactions ‡ ‡ CDRI communication number 5986.
score: 1.8285808, Bioorganic & Medicinal Chemistry, 2002, Ram, Vishnu J; Goel, Atul; Sarkhel, Sanjay; Maulik, Prakas R
Ligand and structure based pharmacophore modeling to facilitate novel histone deacetylase 8 inhibitor design
score: 1.8284128, European Journal of Medicinal Chemistry, 2010, Thangapandian, Sundarapandian et. al.
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca 2+ release from sarcoplasmic reticulum of skeletal muscle
score: 1.8283287, Bioorganic & Medicinal Chemistry Letters, 2005, Hosoya, Takamitsu et. al.
Three-dimensional quantitative structure–activity studies of octopaminergic agonists responsible for the inhibition of sex-pheromone production in Hercoverpa armigera
score: 1.8281121, Bioorganic & Medicinal Chemistry, 1999, Hirashima, Akinori et. al.
Docking and 3D-QSAR studies of BMS-806 analogs as HIV-1 gp120 entry inhibitors
score: 1.8280259, European Journal of Medicinal Chemistry, 2009, Teixeira, C.; Serradji, N.; Maurel, F.; Barbault, F.
Synthesis and Biological Evaluation of Antifungal Derivatives of Enfumafungin as Orally Bioavailable Inhibitors of β1,3-Glucan Synthase
score: 1.8280138, Bioorganic & Medicinal Chemistry Letters, 2012, Heasley, Brian H. et. al.
Design, Synthesis and vasodilative activity of tanshinone IIA derivatives
score: 1.8278078, Bioorganic & Medicinal Chemistry Letters, 2012, Bi, Yue-Feng et. al.
Cyclic urea derivatives as potent NK 1 selective antagonists
score: 1.8274407, Bioorganic & Medicinal Chemistry Letters, 2005, Shue, Ho-Jane et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.8274252, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.8274252, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.8274252, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Synthesis and evaluation of anti-thrombotic activity of benzocoumarin amide derivatives
score: 1.8273169, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Synthesis and evaluation of anti-thrombotic activity of benzocoumarin amide derivatives
score: 1.8273169, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Novel ketolide antibiotics with a fused five-membered lactone ring––synthesis, physicochemical and antimicrobial properties
score: 1.8271434, Bioorganic & Medicinal Chemistry, 2004, Hunziker, Daniel et. al.
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production
score: 1.8269621, Bioorganic & Medicinal Chemistry, 2012, Lee, Bit et. al.
Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases
score: 1.826878, Bioorganic & Medicinal Chemistry, 2006, Sondhi, Sham M. et. al.
Novel synthesis of 2′- O-methylguanosine
score: 1.8268419, Bioorganic & Medicinal Chemistry Letters, 2003, Chow, Suetying et. al.
3D QSAR for GSK-3β inhibition by indirubin analogues
score: 1.8267726, European Journal of Medicinal Chemistry, 2006, Zhang, Na et. al.
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
score: 1.8264927, Bioorganic & Medicinal Chemistry, 2012, Lang, Karen Luise et. al.
Synthesis of new bioactive venlafaxine analogs: Novel thiazolidin-4-ones as antimicrobials
score: 1.8263706, Bioorganic & Medicinal Chemistry, 2006, Kavitha, C.V. et. al.
Synthesis and antibacterial activity of 6-O-(heteroaryl-isoxazolyl)propynyl 2-fluoro ketolides
score: 1.8261539, Bioorganic & Medicinal Chemistry Letters, 2012, Sugimoto, Tomohiro et. al.
Discovery of XL413, a potent and selective CDC7 Inhibitor
score: 1.8261317, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Synthesis and biological activity of novel S-Adenosyl- l-homocysteine hydrolase inhibitors
score: 1.8260698, Bioorganic & Medicinal Chemistry, 2003, Steere, Jennifer A; Honek, John F
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
score: 1.8257793, European Journal of Medicinal Chemistry, 2013, Yaziji, Vicente et. al.
Synthesis and structure–activity relationships (SARs) of 1,5-diarylpyrazole cannabinoid type-1 (CB 1) receptor ligands for potential use in molecular imaging
score: 1.8257711, Bioorganic & Medicinal Chemistry, 2006, Donohue, Sean R.; Halldin, Christer; Pike, Victor W.
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone
score: 1.8256622, Bioorganic & Medicinal Chemistry Letters, 2012, Carter, Percy H. et. al.
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone
score: 1.8256622, Bioorganic & Medicinal Chemistry Letters, 2012, Carter, Percy H. et. al.
Combined receptor-based and ligand-based approach to delineate the mode of binding of guaianolide–endoperoxides to PfATP6
score: 1.8255762, Bioorganic & Medicinal Chemistry Letters, 2012, Helal, Mohamed A.; Avery, Mitchell A.
Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation
score: 1.8255153, Bioorganic & Medicinal Chemistry, 2006, Kaffy, Julia et. al.
2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.
score: 1.8254295, Antimicrobial agents and chemotherapy, 2012, Rodrígues-Poveda, Carlos A et. al.
Consensus hologram QSAR modeling for the prediction of human intestinal absorption
score: 1.8253333, Bioorganic & Medicinal Chemistry Letters, 2012, Moda, Tiago L.; Andricopulo, Adriano D.
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors
score: 1.8252433, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Hua et. al.
Analogues of the mycobacterial arabinogalactan linkage disaccharide as cell wall biosynthesis inhibitors
score: 1.8250862, Bioorganic & Medicinal Chemistry, 2003, Wen, Xianghui et. al.
Potent acetylcholinesterase inhibitors: design, synthesis, and structure–Activity relationships of bis-interacting ligands in the galanthamine series
score: 1.8250204, Bioorganic & Medicinal Chemistry, 1998, Mary, Aude et. al.
Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides
score: 1.8249607, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiaozhuo et. al.
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don
score: 1.8248623, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Yeon Ho et. al.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole- 2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
score: 1.8247887, Bioorganic & Medicinal Chemistry, 2012, Assadieskandar, Amir et. al.
Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants
score: 1.8246226, Bioorganic & Medicinal Chemistry Letters, 2012, Dang, Zhao et. al.
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain
score: 1.8244859, Bioorganic & Medicinal Chemistry, 2003, Huang, Lily; Brinen, Linda S.; Ellman, Jonathan A.
Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis
score: 1.8244101, Bioorganic & Medicinal Chemistry, 2012, Jónsdóttir, Svava Ósk et. al.
Studies of cannabinoid-1 receptor antagonists for the treatment of obesity: Hologram QSAR model for biarylpyrazolyl oxadiazole ligands
score: 1.8243009, Bioorganic & Medicinal Chemistry Letters, 2009, Ye, Mao; Dawson, Marcia I.
Synthesis of [ 11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase
score: 1.824299, Bioorganic & Medicinal Chemistry Letters, 2006, Wang, Ji-Quan et. al.
Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device
score: 1.8240645, Bioorganic & Medicinal Chemistry, 2009, Nishiyama, Kazusa et. al.
New analogues of AHMA as potential antitumor agents: synthesis and biological activity
score: 1.8240501, Bioorganic & Medicinal Chemistry, 2003, Chang, Jang-Yang et. al.
Synthesis and biological evaluation of modified acridines: the effect of N- and O- substituent in the nitrogenated ring on antitumor activity
score: 1.8237153, European Journal of Medicinal Chemistry, 2006, Sánchez, Isabel et. al.
Development of In-Silico Filters to Predict Activation of the Pregnane X Receptor (PXR) by Structurally Diverse Drug-Like Molecules
score: 1.8234708, Bioorganic & Medicinal Chemistry, 2012, Matter, Hans et. al.
N-Alkoxypyrazoles as biomimetics for the alkoxyphenyl group in tamoxifen
score: 1.8231228, Bioorganic & Medicinal Chemistry, 2003, Wenckens, Martin et. al.
Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C 17(20) Lyase
score: 1.8230733, Bioorganic & Medicinal Chemistry, 2002, Burkhart, Joseph P et. al.
Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease
score: 1.822947, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Yun Suk et. al.
Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease
score: 1.822947, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Yun Suk et. al.
Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease
score: 1.822947, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Yun Suk et. al.
Synthesis and biological evaluation of a-Ring biaryl-carbamate analogues of rhazinilam
score: 1.8229103, Bioorganic & Medicinal Chemistry, 2002, Baudoin, Olivier et. al.
Structure–activity relationship study of homoallylamines and related derivatives acting as antifungal agents
score: 1.8228997, Bioorganic & Medicinal Chemistry, 2006, Suvire, Fernando D. et. al.
Highly potent PDE4 inhibitors with therapeutic potential
score: 1.8226582, Bioorganic & Medicinal Chemistry, 2004, Ochiai, Hiroshi et. al.
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
score: 1.8226514, Bioorganic & Medicinal Chemistry Letters, 2012, DeBerardinis, Albert M. et. al.
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
score: 1.8226514, Bioorganic & Medicinal Chemistry Letters, 2012, DeBerardinis, Albert M. et. al.
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
score: 1.8226514, Bioorganic & Medicinal Chemistry Letters, 2012, DeBerardinis, Albert M. et. al.
Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies
score: 1.8226202, Bioorganic & Medicinal Chemistry, 2005, Shim, Yi Sup et. al.
Towards NR2B receptor selective imaging agents for PET—synthesis and evaluation of N-[ 11C]-(2-methoxy)benzyl ( E)-styrene-, 2-naphthyl- and 4-trifluoromethoxyphenylamidine
score: 1.8225595, Bioorganic & Medicinal Chemistry, 2006, Årstad, Erik et. al.
Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7 H-pyrazolo[4,3- d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
score: 1.8222055, Bioorganic & Medicinal Chemistry, 2001, Kim, Dae-Kee et. al.
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.8221397, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294
score: 1.8218557, Bioorganic & Medicinal Chemistry Letters, 2010, Carneiro, Emmanuel O. et. al.
Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics
score: 1.8217166, Bioorganic & Medicinal Chemistry, 2005, Chruma, Jason J.; Liu, Lei; Zhou, Wenjun; Breslow, Ronald
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.8216052, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.8216052, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
score: 1.8216052, Bioorganic & Medicinal Chemistry Letters, 2012, Terao, Yoshito et. al.
Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds
score: 1.8213113, Bioorganic & Medicinal Chemistry, 2004, Venkatachalam, T.K; Mao, C; Uckun, Fatih.M
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations
score: 1.8212766, European Journal of Medicinal Chemistry, 2012, Sgobba, Miriam et. al.
Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists
score: 1.8212179, Bioorganic & Medicinal Chemistry, 2012, Cilibrizzi, Agostino et. al.
Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists
score: 1.8212179, Bioorganic & Medicinal Chemistry, 2012, Cilibrizzi, Agostino et. al.
Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists
score: 1.8212179, Bioorganic & Medicinal Chemistry, 2012, Cilibrizzi, Agostino et. al.
Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents
score: 1.8211728, Bioorganic & Medicinal Chemistry Letters, 2013, Yeung, Kap-Sun et. al.
Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D 3: synthesis and preliminary biological evaluation
score: 1.8205066, Bioorganic & Medicinal Chemistry, 2005, Posner, Gary H. et. al.
Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.
score: 1.8203147, Antimicrobial agents and chemotherapy, 2011, Walker, Scott S et. al.
Guanacastane-type diterpenoids with cytotoxic activity from Coprinus plicatilis
score: 1.8201518, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yuanzhen et. al.
Synthesis and anti- Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs
score: 1.8199176, European Journal of Medicinal Chemistry, 1999, Patrick, Donald A. et. al.
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
score: 1.8196189, European Journal of Medicinal Chemistry, 2012, Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
Design, synthesis and biological evaluation of nonpeptide integrin antagonists
score: 1.8194453, Bioorganic & Medicinal Chemistry, 1998, Nicolaou, K.C. et. al.
Angiogenesis inhibitor TX-1898: syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers
score: 1.8192618, Bioorganic & Medicinal Chemistry, 2004, Jin, Cheng-Zhe et. al.
Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation
score: 1.819037, European Journal of Medicinal Chemistry, 2012, Safavi, Maliheh et. al.
Design, synthesis, and structure–activity relationships of potent GPIIb/IIIa antagonists: discovery of FK419
score: 1.8187861, Bioorganic & Medicinal Chemistry, 2005, Yamanaka, Toshio et. al.
Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents
score: 1.8187378, Bioorganic & Medicinal Chemistry Letters, 2010, Di Gianvincenzo, Paolo et. al.
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8186063, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8186063, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8186063, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation
score: 1.8184532, Bioorganic & Medicinal Chemistry, 2005, Borrel, Christine et. al.
Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp.
score: 1.8182103, Bioorganic & Medicinal Chemistry, 2005, Cao, Shugeng et. al.
Conformations in solution and bound to bacterial ribosomes of ketolides, HMR 3647 (telithromycin) and RU 72366: A new class of highly potent antibacterials
score: 1.8180843, Bioorganic & Medicinal Chemistry, 2000, Evrard-Todeschi, Nathalie et. al.
The structural basis for kainoid selectivity at AMPA receptors revealed by low-mode docking calculations
score: 1.8173404, Bioorganic & Medicinal Chemistry, 2003, Carcache, Luis M; Rodriguez, Jonierr; Rein, Kathleen S
Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine
score: 1.8171927, Bioorganic & Medicinal Chemistry, 2004, Delfourne, Evelyne et. al.
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
score: 1.8169482, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Pinhong et. al.
Synthesis of heterocycles containing two cytosine or two guanine base-pairing sites. Novel tectons for self-assembly
score: 1.8167785, Bioorganic & Medicinal Chemistry, 1996, Petersen, Paul M. et. al.
Quantitative relationship between rat intestinal absorption and Abraham descriptors
score: 1.8163024, European Journal of Medicinal Chemistry, 2003, Zhao, Yuan H et. al.
Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents
score: 1.8160855, European Journal of Medicinal Chemistry, 2012, Zhu, Lingjian et. al.
Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents
score: 1.8160855, European Journal of Medicinal Chemistry, 2012, Zhu, Lingjian et. al.
Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors
score: 1.8159823, European Journal of Medicinal Chemistry, 2013, Abuhaie, Cristina-Maria et. al.
Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors
score: 1.8159823, European Journal of Medicinal Chemistry, 2013, Abuhaie, Cristina-Maria et. al.
Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs
score: 1.8157036, Bioorganic & Medicinal Chemistry, 2006, Hanson, Sarah R.; Whalen, Lisa J.; Wong, Chi-Huey
Novel nitric oxide-releasing isochroman-4-one derivatives: synthesis and evaluation of antihypertensive activity
score: 1.8157033, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
score: 1.8154246, Bioorganic & Medicinal Chemistry Letters, 2012, Hansen, Finn K. et. al.
3-Bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin: Synthesis and antiviral activity
score: 1.8152371, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Chong; Chen, Qi; Schneller, Stewart W.
Synthesis and testing of a triaza-cyclopenta[ b]phenanthrene scaffold as a DNA binding agent
score: 1.8151575, Bioorganic & Medicinal Chemistry, 2006, Hooda, Jaipal et. al.
Novel synthesis of nicotinamide derivatives of cytotoxic properties
score: 1.8151156, Bioorganic & Medicinal Chemistry, 2006, Girgis, Adel S.; Hosni, Hanaa M.; Barsoum, Flora F.
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists
score: 1.8149159, Bioorganic & Medicinal Chemistry, 2006, Naganawa, Atsushi et. al.
Synthesis and anticancer evaluation of certain indolo[2,3- b]quinoline derivatives
score: 1.8149114, Bioorganic & Medicinal Chemistry, 2004, Chen, Yeh-Long et. al.
Non-thiol Farnesyltransferase Inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic Acid Amides
score: 1.8148523, Bioorganic & Medicinal Chemistry, 2002, Sakowski, Jacek; Sattler, Isabel; Schlitzer, Martin
Discovery of novel α1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands
score: 1.814254, Bioorganic & Medicinal Chemistry, 2013, Jørgensen, Morten et. al.
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety
score: 1.8141942, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Qing-Rong et. al.
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety
score: 1.8141942, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Qing-Rong et. al.
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety
score: 1.8141942, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Qing-Rong et. al.
Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors
score: 1.8140486, Bioorganic & Medicinal Chemistry, 2005, Chen, Qiao-Hong; Rao, P.N. Praveen; Knaus, Edward E.
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
score: 1.8135264, European Journal of Medicinal Chemistry, 2012, Pasquini, Serena et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8130641, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8130641, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
score: 1.8128946, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
score: 1.8128946, Bioorganic & Medicinal Chemistry Letters, 2012, Bahl, Ash et. al.
Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives
score: 1.8127819, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives
score: 1.8127819, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives
score: 1.8127819, Bioorganic & Medicinal Chemistry Letters, 2012, Parhi, Ajit et. al.
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
score: 1.8127527, European Journal of Medicinal Chemistry, 2012, van Heerden, Lezanne et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.8122786, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.8122786, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.8122786, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8118305, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
score: 1.8118305, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Novel diaryl ureas with efficacy in a mouse model of malaria
score: 1.8117319, Bioorganic & Medicinal Chemistry Letters, 2013, Anderson, John W. et. al.
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors
score: 1.811448, European Journal of Medicinal Chemistry, 2012, Iranshahi, Mehrdad et. al.
Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation
score: 1.8112373, Bioorganic & Medicinal Chemistry Letters, 2012, Nemoto, Hisao et. al.
Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies
score: 1.811097, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xinyang et. al.
Design, synthesis, and development of novel caprolactam anticonvulsants
score: 1.8104065, Bioorganic & Medicinal Chemistry, 2003, Grimm, Jonathan B; Stables, James P; Brown, Milton L
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
score: 1.8103884, European Journal of Medicinal Chemistry, 2012, Nammalwar, Baskar et. al.
Synthesis and receptor assay of aromatic–ethynyl–aromatic derivatives with potent mGluR5 antagonist activity
score: 1.8103372, Bioorganic & Medicinal Chemistry, 2005, Alagille, David et. al.
An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction
score: 1.8100354, Bioorganic & Medicinal Chemistry Letters, 2012, Hossein nia, Roghayeh et. al.
Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist
score: 1.8098429, Bioorganic & Medicinal Chemistry, 2005, Andersen, Trine F. et. al.
BC-spiro-estradiols. Synthesis and estrogen receptor binding affinity of four new estradiol isomers
score: 1.8095777, Bioorganic & Medicinal Chemistry Letters, 2012, Asim, Muhammad et. al.
Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases
score: 1.8094482, European Journal of Medicinal Chemistry, 2012, Čapkauskaitė, Edita et. al.
Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases
score: 1.8094482, European Journal of Medicinal Chemistry, 2012, Čapkauskaitė, Edita et. al.
A quantitative assessment of hERG liability as a function of lipophilicity
score: 1.8094024, Bioorganic & Medicinal Chemistry Letters, 2007, Waring, Michael J.; Johnstone, Craig
Quantitative structure and aldose reductase inhibitory activity relationship of 1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazine-4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone derivatives
score: 1.8090002, Bioorganic & Medicinal Chemistry, 2005, Ko, Kwangseok; Won, Youngdo
Structure-Based drug design: synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo[ b]oxepines as non-steroidal estrogens
score: 1.8085437, Bioorganic & Medicinal Chemistry, 2003, Sarkhel, Sanjay et. al.
QSAR study on thiazole and thiadiazole analogues as antagonists for the adenosine A 1 and A 3 receptors
score: 1.8084862, Bioorganic & Medicinal Chemistry, 2005, Borghini, Alice et. al.
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus
score: 1.8083637, Bioorganic & Medicinal Chemistry Letters, 2013, Park, Kaapjoo et. al.
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
score: 1.8082819, Bioorganic & Medicinal Chemistry, 2012, Perez-Meseguer, Jonathan et. al.
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
score: 1.8082819, Bioorganic & Medicinal Chemistry, 2012, Perez-Meseguer, Jonathan et. al.
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
score: 1.8082819, Bioorganic & Medicinal Chemistry, 2012, Perez-Meseguer, Jonathan et. al.
Stimulation on DNA triplet repeat strand slippage synthesis by the designed spirocycles
score: 1.8081566, Bioorganic & Medicinal Chemistry Letters, 2006, Xi, Zhen; Ouyang, Di; Mu, Hong-Tao
Total synthesis and stereochemistry of cytoblastin
score: 1.8081147, Bioorganic & Medicinal Chemistry, 1998, Moreno, Ofir A.; Kishi, Yoshito
Protein structure based rational design of ecdysone agonists
score: 1.80804, Bioorganic & Medicinal Chemistry, 2009, Holmwood, Graham; Schindler, Michael
QSAR studies of N 1-(5-chloro-2-pyridyl)-2-{[4-(alkyl methyl)benzoyl]amino}-5-chlorobenzamide analogs
score: 1.8074433, Bioorganic & Medicinal Chemistry, 2006, Rameshwar, N. et. al.
Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT
score: 1.8074312, Bioorganic & Medicinal Chemistry, 2012, Clark, Rachel L. et. al.
Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
score: 1.8071101, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Aesop et. al.
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity
score: 1.8069572, Bioorganic & Medicinal Chemistry Letters, 2012, Peña, Stella et. al.
Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties
score: 1.8067618, Bioorganic & Medicinal Chemistry Letters, 2008, Kamino, Shinichiro et. al.
Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators
score: 1.8067215, Bioorganic & Medicinal Chemistry, 2012, Sabbah, Mohamad et. al.
Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [ 3H]Glyburide binding to rat brain synaptosomes
score: 1.8066906, Bioorganic & Medicinal Chemistry, 2003, Hill, Ronald A. et. al.
Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease.
score: 1.8065877, Antimicrobial agents and chemotherapy, 2006, Perni, Robert B et. al.
Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.
score: 1.8064643, Antimicrobial agents and chemotherapy, 2000, Gozalbes, R et. al.
Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity
score: 1.8063736, Bioorganic & Medicinal Chemistry, 2006, Zhao, Ming et. al.
Three-dimensional quantitative structure–activity relationship analyses of piperidine-based CCR5 receptor antagonists
score: 1.8060942, Bioorganic & Medicinal Chemistry, 2004, Song, Minghu; Breneman, Curt M.; Sukumar, N.
Synthesis and selective anticancer activity of steroidal glycoconjugates
score: 1.8059284, European Journal of Medicinal Chemistry, 2012, Fernández-Herrera, María A. et. al.
Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains
score: 1.8058795, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Shuxiang et. al.
2-Arylbenzofuran-Based Molecules As Multipotent Alzheimer's Disease Modifying Agents
score: 1.8057094, European Journal of Medicinal Chemistry, 2012, Rizzo, Stefano et. al.
Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3′- C-ethynyluridine (EUrd) and 3′- C-ethynylcytidine (ECyd)
score: 1.8053909, Bioorganic & Medicinal Chemistry, 2005, Hrdlicka, Patrick J. et. al.
The therapeutic journey of benzimidazoles: A review
score: 1.8053298, Bioorganic & Medicinal Chemistry, 2012, Bansal, Yogita; Silakari, Om
The therapeutic journey of benzimidazoles: A review
score: 1.8053298, Bioorganic & Medicinal Chemistry, 2012, Bansal, Yogita; Silakari, Om
Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica
score: 1.8051592, European Journal of Medicinal Chemistry, 2005, Sharma, Sangita et. al.
Potent inhibitors of the hepatitis C virus NS3 protease: Use of a novel P2 cyclopentane-derived template
score: 1.8050915, Bioorganic & Medicinal Chemistry, 2006, Johansson, Per-Ola et. al.
Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors
score: 1.8050297, Bioorganic & Medicinal Chemistry, 2003, Hu, Wenhui et. al.
Effect of substitution at N″-position of N′-hydroxy-N-amino guanidines on tumor cell growth
score: 1.8042659, Bioorganic & Medicinal Chemistry Letters, 2012, Basu, Arijit et. al.
An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivatives
score: 1.804252, Bioorganic & Medicinal Chemistry Letters, 2012, Chobe, Santosh S. et. al.
An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivatives
score: 1.804252, Bioorganic & Medicinal Chemistry Letters, 2012, Chobe, Santosh S. et. al.
Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2
score: 1.8042449, European Journal of Medicinal Chemistry, 2012, Caballero, Julio et. al.
Ligand design and synthesis of new imidazo[5,1- b]quinazoline derivatives as α 1-adrenoceptor agonists and antagonists
score: 1.8041838, Bioorganic & Medicinal Chemistry, 2006, Ismail, Mohamed A.H. et. al.
New multipotent tetracyclic tacrines with neuroprotective activity
score: 1.8039904, Bioorganic & Medicinal Chemistry, 2006, Marco-Contelles, José et. al.
Synthesis and antitumor activity of duocarmycin derivatives: modification at the C-7 position of segment-A of A-ring pyrrole compounds
score: 1.8038577, Bioorganic & Medicinal Chemistry, 2000, Amishiro, Nobuyoshi et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.8038127, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Synthesis and evaluation of small libraries of triazolylmethoxy chalcones, flavanones and 2-aminopyrimidines as inhibitors of mycobacterial FAS-II and PknG
score: 1.803684, Bioorganic & Medicinal Chemistry, 2012, Anand, Namrata et. al.
Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes
score: 1.8032083, Bioorganic & Medicinal Chemistry, 2003, Ghosh, Usha et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8031811, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8031811, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
score: 1.8031811, Bioorganic & Medicinal Chemistry Letters, 2012, Muratake, Hideaki et. al.
Design, synthesis and cytotoxic effect of hydroxy- and 3-alkylaminopropoxy-9,10-anthraquinone derivatives
score: 1.8030397, Bioorganic & Medicinal Chemistry, 2005, Teng, Chi-Huang; Won, Shen-Jeu; Lin, Chun-Nan
Synthesis and biological evaluation of novel 2, 4, 6-triazine derivatives as antimicrobial agents
score: 1.8029506, Bioorganic & Medicinal Chemistry Letters, 2012, Gavade, Sandip N. et. al.
Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).
score: 1.8027476, Antimicrobial agents and chemotherapy, 2012, McPhee, Fiona et. al.
Triazolbenzo[d]thiazoles: Efficient synthesis and biological evaluation as neuroprotective agents
score: 1.8027212, Bioorganic & Medicinal Chemistry Letters, 2012, Avila, Belem et. al.
QSAR analysis of 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridines with anticancer activity
score: 1.802453, European Journal of Medicinal Chemistry, 2007, Atanasova, Mariyana; Ilieva, Sonia; Galabov, Boris
Active site binding modes of the β-diketoacids: a multi-active site approach in HIV-1 integrase inhibitor design
score: 1.8014849, Bioorganic & Medicinal Chemistry, 2004, Dayam, Raveendra; Neamati, Nouri
Tuberculosis: The drug development pipeline at a glance
score: 1.8014841, European Journal of Medicinal Chemistry, 2012, Villemagne, Baptiste et. al.
Tuberculosis: The drug development pipeline at a glance
score: 1.8014841, European Journal of Medicinal Chemistry, 2012, Villemagne, Baptiste et. al.
Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti- Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design
score: 1.8011944, European Journal of Medicinal Chemistry, 2004, Aguirre, Gabriela et. al.
Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists
score: 1.8011725, Bioorganic & Medicinal Chemistry, 1996, Ojo, Babatunde et. al.
Synthesis of the tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium
score: 1.8010253, Bioorganic & Medicinal Chemistry Letters, 2006, Saksena, Rina; Adamo, Roberto; Kováč, Pavol
Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity
score: 1.8006475, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity
score: 1.8006475, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity
score: 1.8006475, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles
score: 1.8006329, European Journal of Medicinal Chemistry, 2003, Shivarama Holla, B et. al.
Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide incorporating 7-deazaguanine bases
score: 1.8005353, Bioorganic & Medicinal Chemistry, 2006, Jain, Moti L.; Bruice, Thomas C.
Potent DNA gyrase inhibitors; novel 5-vinylpyrazole analogues with Gram-positive antibacterial activity
score: 1.8002571, Bioorganic & Medicinal Chemistry Letters, 2004, Tanitame, Akihiko et. al.
Synthesis and biological activity of isopentenyl diphosphate analogues
score: 1.7998896, Bioorganic & Medicinal Chemistry, 2004, Scholte, Andrew A et. al.
Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties
score: 1.7997231, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Yan; Ma, Long-Xu; Niu, Tian-Wei; Cui, Xun; Piao, Hu-Ri
Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties
score: 1.7997231, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Yan; Ma, Long-Xu; Niu, Tian-Wei; Cui, Xun; Piao, Hu-Ri
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones
score: 1.7995868, Bioorganic & Medicinal Chemistry, 2003, Kang, Ji-Hye et. al.
2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents
score: 1.7992311, European Journal of Medicinal Chemistry, 2013, Azizmohammadi, Mohammad et. al.
Synthesis of highly deuterium-labeled ( R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma
score: 1.799166, Bioorganic & Medicinal Chemistry, 2009, Yamazaki, Yukiyoshi; Ogawa, Shin-ichiro; Shibuya, Kimiyuki
Facile synthesis and application of uniformly 13C, 15N-labeled phosphotyrosine for ligand binding studies
score: 1.7989625, Bioorganic & Medicinal Chemistry Letters, 2006, Tuin, Adriaan W. et. al.
Newer N-substituted anthranilic acid derivatives as potent anti-inflammatory agents
score: 1.7987048, European Journal of Medicinal Chemistry, 2002, Sharma, Shalabh; Srivastava, Virendra Kishor; Kumar, Ashok
Synthesis and biological evaluation of 5-arylamino-1 H-benzo[ d]imidazole-4,7-diones as inhibitor of endothelial cell proliferation
score: 1.7985542, Bioorganic & Medicinal Chemistry, 2006, Chung, Kwang-Hoe et. al.
Prediction of the aqueous solvation free energy of organic compounds by using autocorrelation of molecular electrostatic potential surface properties combined with response surface analysis
score: 1.7985357, Bioorganic & Medicinal Chemistry, 2008, Michielan, Lisa et. al.
Novel (4-Piperidin-1-yl)-phenyl Sulfonamides as Potent and Selective Human β 3 Agonists
score: 1.7978852, Bioorganic & Medicinal Chemistry, 2001, Hu, Baihua et. al.
Structure–activity study of l-amino acid-based N-type calcium channel blockers
score: 1.7977265, Bioorganic & Medicinal Chemistry, 2003, Seko, Takuya et. al.
An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivatives
score: 1.7976747, Bioorganic & Medicinal Chemistry Letters, 2012, Chobe, Santosh S. et. al.
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds
score: 1.797638, Bioorganic & Medicinal Chemistry, 2012, Lauro, Gianluigi et. al.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition
score: 1.7973164, Bioorganic & Medicinal Chemistry Letters, 2012, Dossetter, Alexander G. et. al.
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping
score: 1.7969078, European Journal of Medicinal Chemistry, 2013, Chen, Qianqian et. al.
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping
score: 1.7969078, European Journal of Medicinal Chemistry, 2013, Chen, Qianqian et. al.
Synthesis of thiophenecarboxamides, thieno[3,4- c]pyridin-4(5 H)-ones and thieno[3,4- d]pyrimidin-4(3 H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)
score: 1.7965583, Bioorganic & Medicinal Chemistry, 1999, Shinkwin, Anne E. et. al.
Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure–activity relationship study
score: 1.7961117, Bioorganic & Medicinal Chemistry, 2004, Yin, Sheng et. al.
Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1 H-2-imidazolyl]methanols, [5- tert-Butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1 H-2-imidazolyl]methanol, and [2-Hydroxyaryl]-[1-methyl-5-nitro-1 H-2-imidazolyl] ketones
score: 1.7960975, Bioorganic & Medicinal Chemistry, 1997, Arredondo, Y. et. al.
Novel synthesis of 2-Substituted 19-norvitamin D A-ring phosphine oxide from d-glucose as a building block
score: 1.7960938, Bioorganic & Medicinal Chemistry Letters, 2003, Shimizu, Masato et. al.
Mining the NCI antiviral compounds for HIV-1 integrase inhibitors
score: 1.7959061, Bioorganic & Medicinal Chemistry, 2006, Deng, Jinxia et. al.
Synthesis and structure–activity relationship of disubstituted benzamides as a novel class of antimalarial agents
score: 1.795805, Bioorganic & Medicinal Chemistry Letters, 2012, Mitachi, Katsuhiko et. al.
Synthesis and structure–activity relationship of disubstituted benzamides as a novel class of antimalarial agents
score: 1.795805, Bioorganic & Medicinal Chemistry Letters, 2012, Mitachi, Katsuhiko et. al.
New saccharin derivatives as tyrosinase inhibitors
score: 1.7957506, Bioorganic & Medicinal Chemistry, 2012, Gençer, Nahit et. al.
The application of a 3D-QSAR ( autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: Application to a lead optimization of a human A 3 adenosine receptor antagonist
score: 1.7957354, Bioorganic & Medicinal Chemistry, 2006, Moro, Stefano et. al.
Dicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations.
score: 1.7955294, Antimicrobial agents and chemotherapy, 2001, Nelson, R G; Rosowsky, A
Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509
score: 1.7952676, Bioorganic & Medicinal Chemistry, 1997, Hagishita, Sanji et. al.
Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509
score: 1.7952676, Bioorganic & Medicinal Chemistry, 1997, Hagishita, Sanji et. al.
Synthesis and muscarinic activities of O-[(Benzyl- or benzoyl-pyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone
score: 1.7948675, Bioorganic & Medicinal Chemistry, 2003, Rodrı́guez-Franco, Marı́a Isabel et. al.
Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
score: 1.7947652, Bioorganic & Medicinal Chemistry Letters, 2012, Uno, Masaharu et. al.
In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B
score: 1.7947119, Bioorganic & Medicinal Chemistry, 2012, Brvar, Matjaž et. al.
Squalenoyl nucleoside monophosphate nanoassemblies: New prodrug strategy for the delivery of nucleotide analogues
score: 1.7947056, Bioorganic & Medicinal Chemistry Letters, 2010, Caron, Joachim et. al.
Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors
score: 1.7946806, Bioorganic & Medicinal Chemistry Letters, 2004, Xu, Yong et. al.
Pyrrolidinobenzoic Acid Inhibitors of Influenza Virus Neuraminidase: the Hydrophobic Side Chain Influences Type A Subtype Selectivity
score: 1.794599, Bioorganic & Medicinal Chemistry, 2012, Li, Yanwu et. al.
Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties
score: 1.7945454, Bioorganic & Medicinal Chemistry, 2004, Johnsamuel, Jayaseharan et. al.
Characterization of novel antimicrobial peptoids.
score: 1.794479, Antimicrobial agents and chemotherapy, 1999, Goodson, B et. al.
Ligand discovery from a dopamine D3 receptor homology model and crystal structure.
score: 1.7942801, Nature chemical biology, 2011, Carlsson, Jens et. al.
The development of first Staphylococcus aureus SplB protease inhibitors: Phosphonic analogues of glutamine
score: 1.7935358, Bioorganic & Medicinal Chemistry Letters, 2012, Ewa, Burchacka et. al.
Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-β-carbolines
score: 1.7934126, Bioorganic & Medicinal Chemistry, 2005, Laronze, M. et. al.
Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents
score: 1.7933988, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Suhyun; Cho, Sang-Nae; Oh, Taegwon; Kim, Pilho
Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents
score: 1.7933988, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, SuHyun; Cho, Sang-Nae; Oh, Taegwon; Kim, Pilho
Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents
score: 1.7933988, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Suhyun; Cho, Sang-Nae; Oh, Taegwon; Kim, Pilho
Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor
score: 1.7929336, Bioorganic & Medicinal Chemistry Letters, 2005, Pontillo, Joseph et. al.
Biotransformation of gentiopicroside by asexual mycelia of Cordyceps sinensis
score: 1.7927028, Bioorganic & Medicinal Chemistry Letters, 2007, Wang, Dong et. al.
Exploration of the importance of the P 2-P 3 -NHCO-Moiety in a potent di- or tripeptide inhibitor of calpain i: insights into the development of nonpeptidic inhibitors of calpain I 1 1 Dedicated to Mrs Luxmi Chatterjee with respect and admiration.
score: 1.7920918, Bioorganic & Medicinal Chemistry, 1998, Chatterjee, Sankar et. al.
5′-Alkyl-benzothiadiazides: A New Subgroup of AMPA Receptor Modulators with Improved Affinity
score: 1.7916576, Bioorganic & Medicinal Chemistry, 2002, Phillips, Dean et. al.
Conformational search of antisense nucleotides
score: 1.7916552, Bioorganic & Medicinal Chemistry Letters, 2001, Alcaro, Stefano et. al.
Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity
score: 1.7912709, Bioorganic & Medicinal Chemistry Letters, 2012, Magedov, Igor V. et. al.
Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents
score: 1.7910549, Bioorganic & Medicinal Chemistry Letters, 2003, Poreddy, Amruta R. et. al.
Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents
score: 1.790911, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Yin et. al.
Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents
score: 1.790911, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Yin et. al.
Structure–activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent
score: 1.7907494, Bioorganic & Medicinal Chemistry, 2012, Mun, Jiyoung et. al.
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents
score: 1.7906387, Bioorganic & Medicinal Chemistry, 2006, Yoshida, Ken-ichi et. al.
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism
score: 1.7905114, Bioorganic & Medicinal Chemistry Letters, 2012, Pryde, David C. et. al.
Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: Optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase
score: 1.7904808, Bioorganic & Medicinal Chemistry, 2004, Yano, Shingo et. al.
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors
score: 1.7903003, Bioorganic & Medicinal Chemistry Letters, 2012, Sukalovic, Vladimir et. al.
Analogs of N’-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
score: 1.7901764, Bioorganic & Medicinal Chemistry, 2012, Bhat, Shridhar et. al.
Lewis acid-promoted transformation of 2-alkoxypyridines into 2-aminopyridines and their antibacterial activity. Part 2: Remarkably facile C–N bond formation
score: 1.7899813, Bioorganic & Medicinal Chemistry, 2005, Abdel-Aziz, Alaa A.-M. et. al.
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
score: 1.7899014, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
score: 1.7899014, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
score: 1.7899014, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7897697, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
Synthesis and in vitro stability of nucleoside 5’-phosphonate derivatives
score: 1.7895581, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Part 5
score: 1.7893234, Bioorganic & Medicinal Chemistry, 2006, Hazeldine, Stuart T. et. al.
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
score: 1.7892529, European Journal of Medicinal Chemistry, 2012, Gaspar, Alexandra et. al.
Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives
score: 1.7892437, Bioorganic & Medicinal Chemistry Letters, 2012, Pérez-Cruz, Fernanda et. al.
Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide
score: 1.7892373, Bioorganic & Medicinal Chemistry Letters, 2012, Hasuda, Tomoyo et. al.
Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors.
score: 1.7890078, Antimicrobial agents and chemotherapy, 2007, Boyne, Melissa E et. al.
QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors
score: 1.7888485, Bioorganic & Medicinal Chemistry Letters, 2006, Narsinghani, Tamanna; Chaturvedi, S.C.
First Example of an Antibody-Catalyzed Aza Diels–Alder Reaction
score: 1.7888354, Bioorganic & Medicinal Chemistry Letters, 2002, Shi, Zhen-Dan et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7886425, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7886425, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7886425, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
QSTR with extended topochemical atom indices. Part 5: Modeling of the acute toxicity of phenylsulfonyl carboxylates to Vibrio fischeri using genetic function approximation
score: 1.7885328, Bioorganic & Medicinal Chemistry, 2005, Roy, Kunal; Ghosh, Gopinath
Synthesis and biological evaluation of carboacyclic nucleosides with ( Z) and ( E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain
score: 1.7884474, Bioorganic & Medicinal Chemistry, 2006, Tang, Ye; Muthyala, Ramaiah; Vince, Robert
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.78809, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.78809, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.78809, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
studies on anti- helicobacter pylori agents. part 2: new cephem derivatives
score: 1.7872456, Bioorganic & Medicinal Chemistry, 2000, Yoshida, Yoshiki et. al.
New diterpene furanoids from the Antarctic lichen Huea sp
score: 1.7871623, Bioorganic & Medicinal Chemistry Letters, 2012, Cui, Yinglan et. al.
New diterpene furanoids from the Antarctic lichen Huea sp
score: 1.7871623, Bioorganic & Medicinal Chemistry Letters, 2012, Cui, Yinglan et. al.
New diterpene furanoids from the Antarctic lichen Huea sp
score: 1.7871623, Bioorganic & Medicinal Chemistry Letters, 2012, Cui, Yinglan et. al.
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
score: 1.7870158, Bioorganic & Medicinal Chemistry Letters, 2012, Tamboli, Yasinalli et. al.
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
score: 1.7870158, Bioorganic & Medicinal Chemistry Letters, 2012, Tamboli, Yasinalli et. al.
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
score: 1.7870158, Bioorganic & Medicinal Chemistry Letters, 2012, Tamboli, Yasinalli et. al.
Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α1-adrenoceptor antagonistic properties
score: 1.7865047, Bioorganic & Medicinal Chemistry, 2012, Handzlik, Jadwiga et. al.
Design of a small-molecule entry inhibitor with activity against primary measles virus strains.
score: 1.7864445, Antimicrobial agents and chemotherapy, 2005, Plemper, Richard K et. al.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption
score: 1.7864097, Bioorganic & Medicinal Chemistry, 2012, Okaniwa, Masanori et. al.
A divergent chemoenzymatic route to an intermediate for nucleoside analogues
score: 1.7862475, Bioorganic & Medicinal Chemistry Letters, 2005, Basak, Amit; Bisai, Shrabani
In vitro antifungal evaluation and structure–activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall
score: 1.7861425, Bioorganic & Medicinal Chemistry, 2001, López, Silvia N et. al.
Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3- d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3- d]pyrimidine as antifolates
score: 1.7860272, Bioorganic & Medicinal Chemistry, 2006, Gangjee, Aleem; Yang, Jie; McGuire, John J.; Kisliuk, Roy L.
Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien
score: 1.7860053, Bioorganic & Medicinal Chemistry Letters, 2012, Altendorfer, Mario; Irschik, Herbert; Menche, Dirk
Synthesis and antihyperglycemic activity profiles of novel thiazolidinedione derivatives
score: 1.7857338, Bioorganic & Medicinal Chemistry, 2004, Bhat, Bashir A. et. al.
Effects of new ubiquinone-imidazo[2,1- b]thiazoles on mitochondrial complex I (NADH-ubiquinone reductase) and on mitochondrial permeability transition pore
score: 1.7856108, Bioorganic & Medicinal Chemistry, 2004, Andreani, Aldo et. al.
Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
score: 1.7855194, Bioorganic & Medicinal Chemistry, 2012, Herth, Matthias M. et. al.
Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
score: 1.7855194, Bioorganic & Medicinal Chemistry, 2012, Herth, Matthias M. et. al.
Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
score: 1.7855194, Bioorganic & Medicinal Chemistry, 2012, Herth, Matthias M. et. al.
Synthesis and antimicrobial activity of some novel derivatives of benzofuran: part 1. Synthesis and antimicrobial activity of (benzofuran-2-yl)(3-phenyl-3-methylcyclobutyl) ketoxime derivatives
score: 1.785504, European Journal of Medicinal Chemistry, 2005, Koca, Murat et. al.
Facile synthesis of anthracene-appended amino acids as highly selective and sensitive fluorescent Fe 3+ ion sensors
score: 1.7851632, Bioorganic & Medicinal Chemistry Letters, 2009, Lohani, Chuda Raj; Kim, Joung-Min; Lee, Keun-Hyeung
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants
score: 1.7850458, European Journal of Medicinal Chemistry, 2012, Mladenović, Milan et. al.
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
score: 1.7847365, Bioorganic & Medicinal Chemistry Letters, 2012, Dai, Hou-ling et. al.
SAR directed design and synthesis of novel β(1-4)-Glucosyltransferase inhibitors and Their In vitro inhibition studies
score: 1.7845573, Bioorganic & Medicinal Chemistry, 2002, Bhattacharya, Asish K et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7843806, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7843806, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7843806, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Novel small renin inhibitors containing 4,5- or 3,5-dihydroxy-2-substituted-6-phenylhexanamide replacements at the P 2P 3 sites
score: 1.7842527, Bioorganic & Medicinal Chemistry, 1998, Jung, Grace L. et. al.
A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolothiazoles as antimycobacterial agents
score: 1.7841717, Bioorganic & Medicinal Chemistry Letters, 2012, Almansour, Abdulrahman I. et. al.
A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolidines as antimycobacterial agents
score: 1.7841717, Bioorganic & Medicinal Chemistry Letters, 2012, Almansour, Abdulrahman I. et. al.
A physicogenetic method to assign ligand-binding relationships between 7TM receptors
score: 1.7836233, Bioorganic & Medicinal Chemistry Letters, 2005, Frimurer, Thomas M. et. al.
The effect PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
The effect of PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
The effect PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
The effect of PLC-γ2 inhibitors on the growth of human tumour cells
score: 1.7833585, European Journal of Medicinal Chemistry, 2012, Feng, Linda; Reynisdóttir, Inga; Reynisson, Jóhannes
Structure–activity relationships of antileishmanial and antimalarial chalcones
score: 1.782865, Bioorganic & Medicinal Chemistry, 2003, Liu, Mei et. al.
Aza-bicyclic amino acid carboxamides as α 4β 1/α 4β 7 integrin receptor antagonists
score: 1.7828051, Bioorganic & Medicinal Chemistry, 2005, Dyatkin, Alexey B. et. al.
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
score: 1.7827504, Antimicrobial agents and chemotherapy, 2012, Hall, Belinda S; Meredith, Emma Louise; Wilkinson, Shane R
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position
score: 1.7826681, Bioorganic & Medicinal Chemistry Letters, 2012, Hamada, Yoshio et. al.
Longifolicin, longicoricin, and gigantetroneninone, three novel bioactive mono-tetrahydrofuran annonaceous acetogenins from Asimina longifolia (annonaceae)
score: 1.7823096, Bioorganic & Medicinal Chemistry, 1996, Ye, Qing et. al.
Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase
score: 1.7819102, Bioorganic & Medicinal Chemistry, 2003, Njoroge, F.George et. al.
Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[ b]furan-3 a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition
score: 1.781838, Bioorganic & Medicinal Chemistry, 2004, Watts, John et. al.
Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3 H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigations
score: 1.7816647, Bioorganic & Medicinal Chemistry, 2005, Mamolo, Maria Grazia et. al.
Synthesis and DNA-binding ability of pyrrolo[2,1- c][1,4]benzodiazepine-azepane conjugates
score: 1.7815794, Bioorganic & Medicinal Chemistry Letters, 2006, Kamal, Ahmed et. al.
Exploring human adenosine A 3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety
score: 1.7814176, Bioorganic & Medicinal Chemistry, 2005, Van Rompaey, Philippe et. al.
Prenylated chalcones isolated from Crotalaria genus inhibits in vitro growth of the human malaria parasite Plasmodium falciparum
score: 1.7808073, Bioorganic & Medicinal Chemistry Letters, 2005, Narender, T. et. al.
Benzimidazole derivatives. Part 5: Design and synthesis of new benzimidazole–arylpiperazine derivatives acting as mixed 5-HT 1A/5-HT 3 ligands
score: 1.7807389, Bioorganic & Medicinal Chemistry, 2004, López-Rodríguez, María L. et. al.
Structure–activity relationship at α-adrenergic receptors within a series of imidazoline analogues of cirazoline
score: 1.7807183, Bioorganic & Medicinal Chemistry, 2000, Pigini, Maria et. al.
5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5- a]pyrazin-4(5 H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis
score: 1.7806604, Bioorganic & Medicinal Chemistry, 2008, Pan, Xiao-Hong et. al.
Development of 3,4-dihydro-2 H-benzo[1,4]oxazine derivatives as dual thromboxane A 2 receptor antagonists and prostacyclin receptor agonists
score: 1.7805906, Bioorganic & Medicinal Chemistry, 2006, Ohno, Michihiro et. al.
Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
score: 1.780408, Antimicrobial agents and chemotherapy, 2011, Barker, Robert H et. al.
Synthesis and Structure-Activity Relationship of Potent, Selective and Orally Active Anthranilamide-Based Factor Xa Inhibitors: Application of Weakly Basic Sulfoximine Group as Novel S4 Binding Element
score: 1.7802954, European Journal of Medicinal Chemistry, 2012, Pandya, Vrajesh et. al.
Probing the proposed phenyl-A region of the sigma-1 receptor
score: 1.7802844, Bioorganic & Medicinal Chemistry, 2002, Ablordeppey, Seth Y et. al.
Synthesis of novel Gn-RH analogues using Ugi-4MCR
score: 1.7800545, Bioorganic & Medicinal Chemistry Letters, 2009, Arabanian, Armin et. al.
2D QSAR of PPARγ agonist binding and transactivation
score: 1.7800215, Bioorganic & Medicinal Chemistry, 2006, Rücker, Christoph; Scarsi, Marco; Meringer, Markus
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase
score: 1.779815, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase
score: 1.779815, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase
score: 1.779815, Bioorganic & Medicinal Chemistry Letters, 2012, Barawkar, Dinesh A. et. al.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.779809, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents
score: 1.7796337, Bioorganic & Medicinal Chemistry, 2013, Apostolidis, I. et. al.
Structure–activity studies of FIV and HIV protease inhibitors containing allophenylnorstatine
score: 1.77948, Bioorganic & Medicinal Chemistry, 2001, Le, Van-Duc et. al.
Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues
score: 1.7792329, Bioorganic & Medicinal Chemistry, 1997, Madalengoitia, Jose S. et. al.
Structure–activity studies of 3′-4′-dichloro-meperidine analogues at dopamine and serotonin transporters
score: 1.7792122, Bioorganic & Medicinal Chemistry, 2005, Rhoden, Jill B. et. al.
Synthesis and SOD activity of manganese complexes of substituted pyridino pentaaza macrocycles that contain axial auxiliary
score: 1.7791574, Bioorganic & Medicinal Chemistry Letters, 2010, Lee, Hakyoung; Park, Wonchoul; Lim, Dongyeol
Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors
score: 1.7790905, Bioorganic & Medicinal Chemistry, 2006, Rode, Haridas et. al.
Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity
score: 1.7789799, Bioorganic & Medicinal Chemistry, 2006, Goodell, John R. et. al.
Design, Synthesis, and Biological Evaluation of a Series of β-Lactam-Based Prodrugs
score: 1.7787886, Bioorganic & Medicinal Chemistry, 2002, Hakimelahi, Gholam Hossein et. al.
Microwave-assisted synthesis of unnatural amino acids
score: 1.7781867, Bioorganic & Medicinal Chemistry Letters, 2008, Young, Douglas D. et. al.
Template-competitive inhibitors of HIV-1 reverse transcriptase: design, synthesis and inhibitory activity
score: 1.7781373, Bioorganic & Medicinal Chemistry, 2002, Li, Ke et. al.
2,9-Disubstituted- N 6-(arylcarbamoyl)-8-azaadenines as new selective A 3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies
score: 1.7774745, Bioorganic & Medicinal Chemistry, 2005, Biagi, Giuliana et. al.
Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists
score: 1.7774561, Bioorganic & Medicinal Chemistry Letters, 2013, Gim, Hyo Jin; Li, Hua; Lee, Eun; Ryu, Jae-Ha; Jeon, Raok
Synthesis of acyclic 6,7-dihaloquinolone nucleoside analogues as potential antibacterial and antiviral agents
score: 1.7773841, Bioorganic & Medicinal Chemistry, 2000, Al-Masoudi, Najim A et. al.
Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.
score: 1.7772682, Antimicrobial agents and chemotherapy, 2010, Ribble, Wendy et. al.
The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin
score: 1.7765909, Bioorganic & Medicinal Chemistry Letters, 2012, Gendaszewska-Darmach, Edyta et. al.
The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin
score: 1.7765909, Bioorganic & Medicinal Chemistry Letters, 2012, Gendaszewska-Darmach, Edyta et. al.
Synthesis of an artificial glycoconjugate polymer carrying P k-antigenic trisaccharide and its potent neutralization activity against Shiga-like toxin
score: 1.7764427, Bioorganic & Medicinal Chemistry, 1999, Dohi, Hirofumi et. al.
Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity
score: 1.7763702, Bioorganic & Medicinal Chemistry, 2006, Hořejší, Kateřina et. al.
Structure-based discovery of human l-xylulose reductase inhibitors from database screening and molecular docking
score: 1.776188, Bioorganic & Medicinal Chemistry, 2005, Carbone, Vincenzo et. al.
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
score: 1.7760925, Bioorganic & Medicinal Chemistry Letters, 2012, Raheem, Izzat T. et. al.
A polymer-Supported [1,3,2]Oxazaphospholidine for the conversion of isothiocyanates to isocyanides and Their subsequent use in an ugi reaction
score: 1.7754818, Bioorganic & Medicinal Chemistry Letters, 2002, Ley, Steven V.; Taylor, Stephen J.
Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors
score: 1.7752237, Bioorganic & Medicinal Chemistry, 2012, Zhang, Shuting; Cheng, Kui; Wang, Xiaohui; Yin, Hang
Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs
score: 1.7751537, European Journal of Medicinal Chemistry, 2003, Charlier, Caroline; Michaux, Catherine
Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors
score: 1.7751484, Bioorganic & Medicinal Chemistry, 2004, Ishihara, Tsukasa et. al.
Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases
score: 1.775147, Bioorganic & Medicinal Chemistry, 2012, Wisastra, Rosalina et. al.
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold
score: 1.7750847, Bioorganic & Medicinal Chemistry, 2004, Knight, Zachary A. et. al.
QSAR studies of paeonol analogues for inhibition of platelet aggregation
score: 1.7747858, Bioorganic & Medicinal Chemistry, 2005, Doble, Mukesh et. al.
Synthesis of 4-methylcoumarin derivatives containing 4,5-dihydropyrazole moiety to scavenge radicals and to protect DNA
score: 1.7746187, European Journal of Medicinal Chemistry, 2012, Xiao, Chuan et. al.
C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor
score: 1.7740315, Bioorganic & Medicinal Chemistry Letters, 2012, Dixon, Darryl D. et. al.
Synthesis and biological evaluation of 5 R- and 5 S-methyl substituted d- and l-configuration 1,3-dioxolane nucleoside analogs
score: 1.7739967, Bioorganic & Medicinal Chemistry, 2004, Bera, Sanjib et. al.
Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents
score: 1.7739573, European Journal of Medicinal Chemistry, 2012, Caputto, María E. et. al.
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation
score: 1.773874, Bioorganic & Medicinal Chemistry Letters, 2012, Hicks, Justin W. et. al.
Structure-based engineering of benzalacetone synthase
score: 1.7737385, Bioorganic & Medicinal Chemistry Letters, 2010, Shimokawa, Yoshihiko; Morita, Hiroyuki; Abe, Ikuro
Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents
score: 1.7734637, Bioorganic & Medicinal Chemistry, 2013, Tarleton, Mark et. al.
Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor
score: 1.7734075, Bioorganic & Medicinal Chemistry Letters, 2012, Chaturvedula, Prasad V. et. al.
Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor
score: 1.7734075, Bioorganic & Medicinal Chemistry Letters, 2012, Chaturvedula, Prasad V. et. al.
Efficient synthesis of Idraparinux, the anticoagulant pentasaccharide
score: 1.7733523, Bioorganic & Medicinal Chemistry Letters, 2009, Chen, Chen; Yu, Biao
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
score: 1.7731906, Bioorganic & Medicinal Chemistry, 2012, Park, Ji-Young et. al.
Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
score: 1.7731207, Bioorganic & Medicinal Chemistry, 2012, Moorthy, N.S.H.N. et. al.
Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
score: 1.7731207, Bioorganic & Medicinal Chemistry, 2012, Moorthy, N.S.H.N. et. al.
Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
score: 1.7731207, Bioorganic & Medicinal Chemistry, 2012, Moorthy, N.S.H.N. et. al.
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands
score: 1.7728345, Bioorganic & Medicinal Chemistry, 2006, Zhao, Xue Zhi et. al.
Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors
score: 1.7724726, Bioorganic & Medicinal Chemistry, 2012, Zhang, Dengyou et. al.
Synthesis and in Vitro Antiproliferative Activity of New 11-Aminoalkylamino-Substituted 5H- and 6H-indolo[2,3-b]quinolines; Structure-Activity Relationships of Neocryptolepines and 6-Methyl Congeners
score: 1.7724195, Bioorganic & Medicinal Chemistry, 2012, Wang, Li et. al.
Estimation of the binding affinities of FKBP12 inhibitors using a linear response method
score: 1.7723804, Bioorganic & Medicinal Chemistry, 1999, Lamb, Michelle L. et. al.
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors
score: 1.7723082, Bioorganic & Medicinal Chemistry Letters, 2012, Jalily, Pouria H. et. al.
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors
score: 1.7723082, Bioorganic & Medicinal Chemistry Letters, 2012, Jalily, Pouria H. et. al.
Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: Synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1 H-pyrazol-5-yl)-2-thiophenecarboxamides
score: 1.7722689, Bioorganic & Medicinal Chemistry, 2006, Yonetoku, Yasuhiro et. al.
Combined NMR-crystallographic and modelling investigation of the inclusion of molsidomine into α-, β- and γ-cyclodextrins
score: 1.7722604, Bioorganic & Medicinal Chemistry, 2005, Uccello-Barretta, Gloria et. al.
Ethenesulfonamide and ethanesulfonamide derivatives, a novel class of orally active endothelin-A receptor antagonists
score: 1.7721546, Bioorganic & Medicinal Chemistry, 2001, Harada, Hironori et. al.
Structure–activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors
score: 1.7721094, Bioorganic & Medicinal Chemistry, 2005, Maccari, Rosanna et. al.
Synthesis and antiprotozoal evaluation of benzothiazolopyrroloquinoxalinones, analogues of kuanoniamine A
score: 1.7719798, Bioorganic & Medicinal Chemistry, 2003, Tapia, Ricardo A. et. al.
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA
score: 1.7715734, Bioorganic & Medicinal Chemistry Letters, 2005, Xu, Yufang; Qu, Baoyuan; Qian, Xuhong; Li, Yonggang
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
score: 1.7709579, Antimicrobial agents and chemotherapy, 2004, Bruheim, Per et. al.
Structure–activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity
score: 1.7707282, Bioorganic & Medicinal Chemistry, 2004, Sekine, Mitsuo et. al.
Blocking HIV-1 entry by a gp120 surface binding inhibitor
score: 1.7703765, Bioorganic & Medicinal Chemistry Letters, 2012, Tsou, Lun K. et. al.
Blocking HIV-1 entry by a gp120 surface binding inhibitor
score: 1.7703765, Bioorganic & Medicinal Chemistry Letters, 2012, Tsou, Lun K. et. al.
Discovery and characterization of inhibitors of Pseudomonas aeruginosa type III secretion.
score: 1.7703523, Antimicrobial agents and chemotherapy, 2010, Aiello, Daniel et. al.
N-Alkylation of phenethylamine and tryptamine
score: 1.7702432, Bioorganic & Medicinal Chemistry Letters, 2005, Cami-Kobeci, Gerta et. al.
Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.
score: 1.7700358, Antimicrobial agents and chemotherapy, 2004, Iyer, Radhakrishnan P et. al.
Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.
score: 1.7690865, Bioorganic & Medicinal Chemistry Letters, 2012, Sivasothy, Yasodha et. al.
Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.
score: 1.7690865, Bioorganic & Medicinal Chemistry Letters, 2012, Sivasothy, Yasodha et. al.
Synthesis and evaluation of cis-hexahydropyrrolo[3,2- b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases
score: 1.7689985, Bioorganic & Medicinal Chemistry, 2005, Quibell, Martin et. al.
Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis
score: 1.7685756, Bioorganic & Medicinal Chemistry Letters, 2012, Jeankumar, Variam Ullas et. al.
Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis
score: 1.7685756, Bioorganic & Medicinal Chemistry Letters, 2012, Jeankumar, Variam Ullas et. al.
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase
score: 1.7682361, Bioorganic & Medicinal Chemistry Letters, 2012, Zhu, Rui et. al.
Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine
score: 1.7681924, Bioorganic & Medicinal Chemistry, 2006, Narendra Sharath Chandra, J.N. et. al.
A new class of pyrimidine nucleosides: inhibitors of hepatitis B and C viruses
score: 1.7679816, Bioorganic & Medicinal Chemistry Letters, 2012, Shakya, Neeraj et. al.
Application of descriptors based on Lipinski’s rules in the QSPR study of aqueous solubilities
score: 1.7679081, Bioorganic & Medicinal Chemistry, 2007, Duchowicz, Pablo R. et. al.
Investigation of structure–activity relationships in a series of glibenclamide analogues
score: 1.7676243, European Journal of Medicinal Chemistry, 2004, Yuriev, Elizabeth; Kong, David C.M.; Iskander, Magdy N.
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists
score: 1.7675676, Bioorganic & Medicinal Chemistry Letters, 2012, Dorange, Ismet et. al.
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists
score: 1.7675676, Bioorganic & Medicinal Chemistry Letters, 2012, Dorange, Ismet et. al.
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists
score: 1.7675676, Bioorganic & Medicinal Chemistry Letters, 2012, Dorange, Ismet et. al.
Solid-phase extraction on C18 silica as a purification strategy in the solution synthesis of a 1-thio-β- d-galactopyranoside library
score: 1.7675402, Bioorganic & Medicinal Chemistry, 1998, Nilsson, Ulf J.; Fournier, Eric J.-L.; Hindsgaul, Ole
1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase
score: 1.7674484, Bioorganic & Medicinal Chemistry Letters, 2012, Yacovan, Avihai et. al.
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS)
score: 1.767224, Bioorganic & Medicinal Chemistry Letters, 2012, Annedi, Subhash C. et. al.
Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives with in vivo hypnotic and analgesic profile
score: 1.7670745, Bioorganic & Medicinal Chemistry, 2006, Menegatti, Ricardo et. al.
Structure-Based Discovery of C-2 Substituted Imidazo-pyrrolopyridine JAK1 Inhibitors with Improved Selectivity over JAK2
score: 1.7668642, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid
score: 1.7666619, Bioorganic & Medicinal Chemistry, 1999, Baures, Paul W et. al.
New substituted 4H-chromenes as anticancer agents
score: 1.7663862, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
New substituted 4H-chromenes as anticancer agents
score: 1.7663862, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
New substituted 4H-chromenes as anticancer agents
score: 1.7663862, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Shivaputra A. et. al.
Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity
score: 1.7662959, Bioorganic & Medicinal Chemistry Letters, 2010, Kotoku, Naoyuki et. al.
Synthesis and evaluation of novel potent HCV NS5A inhibitors
score: 1.7662561, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hongwang et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7661042, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7661042, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7661042, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Practical synthesis of all inositol stereoisomers from myo-inositol
score: 1.7659543, Bioorganic & Medicinal Chemistry Letters, 1999, Chung, Sung-Kee; Kwon, Yong-Uk
Design and Synthesis of a Selective EP4-Receptor Agonist. Part 2: 3,7-DithiaPGE 1 Derivatives with High Selectivity
score: 1.7658435, Bioorganic & Medicinal Chemistry, 2002, Maruyama, Toru et. al.
Synthesis and biological evaluation of platinum–acridine hybrid agents modified with bipyridine non-leaving groups
score: 1.7656788, Bioorganic & Medicinal Chemistry Letters, 2009, Kheradi, Alexander R. et. al.
Synthesis of benzamide derivatives and their evaluation as antiprion agents
score: 1.7656079, Bioorganic & Medicinal Chemistry, 2012, Fiorino, Ferdinando et. al.
Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D 3
score: 1.7652773, Bioorganic & Medicinal Chemistry, 2006, Sinishtaj, Sandra et. al.
2-Aminothiophene-3-carboxylates and carboxamides as adenosine A 1 receptor allosteric enhancers
score: 1.7652163, Bioorganic & Medicinal Chemistry, 2006, Nikolakopoulos, George et. al.
A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases
score: 1.7651704, Bioorganic & Medicinal Chemistry Letters, 1999, Mazzucco, Silvia et. al.
Liquid phase parallel synthesis of guanidines
score: 1.764954, Bioorganic & Medicinal Chemistry Letters, 1999, Ko-Chieh Ho, ; Chung-Ming Sun,
Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol
score: 1.7637394, Bioorganic & Medicinal Chemistry Letters, 2012, Hanson, Robert N. et. al.
Formylated polyamines as peptidomimetics
score: 1.7635778, Bioorganic & Medicinal Chemistry Letters, 2012, Javor, Sacha et. al.
Formylated polyamines as peptidomimetics
score: 1.7635778, Bioorganic & Medicinal Chemistry Letters, 2012, Javor, Sacha et. al.
Synthesis, structure–activity relationship and antiviral activity of 3′- N, N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs
score: 1.7633568, European Journal of Medicinal Chemistry, 2010, Singh, Ramendra K. et. al.
Pentacyclic hemiacetal sterol with antifouling and cytotoxic activities from the soft coralNephtheasp.
score: 1.7632702, Bioorganic & Medicinal Chemistry Letters, 2013, Zhang, Jun et. al.
Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α1-adrenoceptor antagonistic properties
score: 1.7630416, Bioorganic & Medicinal Chemistry, 2012, Handzlik, Jadwiga et. al.
Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT 1A receptor agents with anxiolytic- like activity
score: 1.762589, Bioorganic & Medicinal Chemistry, 2006, Bojarski, Andrzej J. et. al.
Shaken not stirred: A facile synthesis of 1,4-bis(furo[2,3- d]-pyrimidine-2,4(1 H,3 H)-dione-5-yl)benzenes by one-pot reaction of isocyanides, N, N′-dimethylbarbituric acid, and terephthaldialdehyde
score: 1.7623845, Bioorganic & Medicinal Chemistry Letters, 2006, Teimouri, Mohammad Bagher; Bazhrang, Reihaneh
Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling
score: 1.7621975, Bioorganic & Medicinal Chemistry, 2004, Pignatello, Rosario et. al.
Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies
score: 1.7621553, Bioorganic & Medicinal Chemistry, 2004, Baraldi, Pier Giovanni et. al.
Structural Studies on Bioactive Compounds. Part 36: Design, Synthesis and Biological Evaluation of Pyrimethamine-Based Antifolates Against Pneumocystis carinii
score: 1.7619509, Bioorganic & Medicinal Chemistry, 2002, Chan, David C.M. et. al.
Design, synthesis and biological evaluation of novel acrylamide analogues as inhibitors of BCR–ABL kinase
score: 1.7619497, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Shuxin et. al.
Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism.
score: 1.7618312, Antimicrobial agents and chemotherapy, 1998, Farnet, C M et. al.
Structure–activity relationships of novel endomorphin-2 analogues with N–O turns induced by α-aminoxy acids
score: 1.761712, Bioorganic & Medicinal Chemistry Letters, 2005, Wei, Jie et. al.
Synthesis and evaluation of antithrombotic activity of benzocoumarin amide derivatives
score: 1.7615333, Bioorganic & Medicinal Chemistry Letters, 2012, Sashidhara, Koneni V. et. al.
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors
score: 1.7614013, Bioorganic & Medicinal Chemistry Letters, 2013, Ho, Koc-Kan et. al.
In vitro cytotoxicity of 5-aminosubstituted 20( S)-camptothecins. part 1
score: 1.7613698, Bioorganic & Medicinal Chemistry, 1999, Subrahmanyam, Duvvuri et. al.
Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives
score: 1.7612594, European Journal of Medicinal Chemistry, 2012, Audisio, Davide et. al.
Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives
score: 1.7612594, European Journal of Medicinal Chemistry, 2012, Audisio, Davide et. al.
Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine
score: 1.7612593, Bioorganic & Medicinal Chemistry Letters, 2005, Wentland, Mark P. et. al.
Drugs, leads, and drug-likeness: an analysis of some recently launched drugs
score: 1.7610727, Bioorganic & Medicinal Chemistry Letters, 2002, Proudfoot, John R.
Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
score: 1.7610342, European Journal of Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
score: 1.7610342, European Journal of Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Thieno[3,2-c]pyran-4-one based novel small molecules: their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents
score: 1.7605106, Bioorganic & Medicinal Chemistry Letters, 2012, Nakhi, Ali et. al.
The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer’s disease
score: 1.7603003, Bioorganic & Medicinal Chemistry Letters, 2013, Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang
Discovery of a new binding mode for a series of liver X receptor agonists
score: 1.7601829, Bioorganic & Medicinal Chemistry Letters, 2012, Kopecky, David J. et. al.
Spirocyclopropyl pyrrolidines as a new series of α- l-fucosidase inhibitors
score: 1.7601134, Bioorganic & Medicinal Chemistry, 2006, Laroche, Christophe et. al.
Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors
score: 1.7597664, Bioorganic & Medicinal Chemistry Letters, 2009, Birch, Alan M. et. al.
Design, Synthesis and SAR Analysis of Novel Potent and Selective Small Molecule Antagonists of NPBWR1 (GPR7)
score: 1.7596939, Bioorganic & Medicinal Chemistry Letters, 2012, Urbano, Mariangela et. al.
Investigation on the isoform selectivity of histone deacetylase inhibitors using chemical feature based pharmacophore and docking approaches
score: 1.7596869, European Journal of Medicinal Chemistry, 2010, Zhu, Yong et. al.
Chlorin e6–cholesterol conjugate and its copper complex. Simple synthesis and entrapping in phospholipid vesicles
score: 1.7596445, Bioorganic & Medicinal Chemistry Letters, 2010, Nikolaeva, Irina A. et. al.
Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: Structure–activity relationships of the 4-anilino group
score: 1.7596055, Bioorganic & Medicinal Chemistry, 2006, Sirisoma, Nilantha et. al.
2-Deoxy-2,3-didehydro- N-acetylneuraminic acid analogues structurally modified at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1
score: 1.7595763, Bioorganic & Medicinal Chemistry, 2006, Ikeda, Kiyoshi et. al.
Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on β-tubulin
score: 1.7590942, Bioorganic & Medicinal Chemistry, 2000, Brown, Milton L; Rieger, Jayson M; Macdonald, Timothy L
Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin
score: 1.7590112, Bioorganic & Medicinal Chemistry, 2006, Hayes, Patricia Y. et. al.
Synthesis and muscarinic activities of 3-(pyrazolyl)-1,2,5,6-tetrahydropyridine derivatives
score: 1.7590068, Bioorganic & Medicinal Chemistry, 1996, Plate, Ralf et. al.
CRHR 1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists
score: 1.7585674, Bioorganic & Medicinal Chemistry, 2002, Hsin, Ling-Wei et. al.
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors
score: 1.7582684, Bioorganic & Medicinal Chemistry Letters, 2012, Parker, Michael F. et. al.
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors
score: 1.7582684, Bioorganic & Medicinal Chemistry Letters, 2012, Parker, Michael F. et. al.
Scaffold hopping strategy towards original pyrazolines as selective CB2 receptor ligands
score: 1.7581738, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance
score: 1.7580509, Bioorganic & Medicinal Chemistry, 2010, Innocenti, Alessio et. al.
Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers
score: 1.7578096, Bioorganic & Medicinal Chemistry Letters, 2006, Gao, Mingzhang et. al.
Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties
score: 1.7572269, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Yan; Ma, Long-Xu; Niu, Tian-Wei; Cui, Xun; Piao, Hu-Ri
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
score: 1.7566258, European Journal of Medicinal Chemistry, 2012, Li, Xue et. al.
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
score: 1.7566258, European Journal of Medicinal Chemistry, 2012, Li, Xue et. al.
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
score: 1.7566258, European Journal of Medicinal Chemistry, 2012, Li, Xue et. al.
Design, synthesis and structure–affinity relationships of 4-methylidenepiperidine and 4-aryl-1,2,3,6-tetrahydropyridine derivatives as corticotropin-releasing factor 1 receptor antagonists
score: 1.7565502, Bioorganic & Medicinal Chemistry, 2000, Nakazato, Atsuro et. al.
Structure–activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure
score: 1.7560996, Bioorganic & Medicinal Chemistry, 2004, Kawanishi, Motoyuki et. al.
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides
score: 1.7559374, Bioorganic & Medicinal Chemistry, 2012, Baruah, Pranjal K. et. al.
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides
score: 1.7559374, Bioorganic & Medicinal Chemistry, 2012, Baruah, Pranjal K. et. al.
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides
score: 1.7559374, Bioorganic & Medicinal Chemistry, 2012, Baruah, Pranjal K. et. al.
In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates.
score: 1.7557905, Antimicrobial agents and chemotherapy, 2011, Suzuki, Takashi et. al.
Allylic thiocyanates as a new class of antitubercular agents
score: 1.7557115, Bioorganic & Medicinal Chemistry Letters, 2012, Silveira, Gustavo P. et. al.
Synthesis and pharmacology of a hybrid cannabinoid
score: 1.7556637, Bioorganic & Medicinal Chemistry, 2000, Huffman, John W. et. al.
Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2,5-disubstituted-8-quinolinamines and some of their amino acid conjugates
score: 1.7556424, Bioorganic & Medicinal Chemistry, 2004, Jain, Meenakshi et. al.
Synthesis and pharmacological evaluation of 5 H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents
score: 1.7555529, Bioorganic & Medicinal Chemistry, 2004, Bruno, Olga et. al.
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
score: 1.7553478, European Journal of Medicinal Chemistry, 2012, Bertinaria, Massimo et. al.
The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents
score: 1.7552269, European Journal of Medicinal Chemistry, 2012, Wang, Lei et. al.
Technetium-99m-labeling and synthesis of thymidine analogs: Potential candidates for tumor imaging
score: 1.7548968, Bioorganic & Medicinal Chemistry Letters, 2007, Teng, Bao et. al.
Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors
score: 1.7546816, Bioorganic & Medicinal Chemistry, 1998, Hinterding, Klaus et. al.
Chemoinformatics: a view of the field and current trends in method development
score: 1.7546221, Bioorganic & Medicinal Chemistry, 2012, Vogt, Martin; Bajorath, Jürgen
Synthesis and biological evaluation of novel PDMP analogues
score: 1.7543864, Bioorganic & Medicinal Chemistry, 2006, Hillaert, Ulrik et. al.
Synthesis and antimicrotubule activity of combretatropone derivatives
score: 1.7539364, Bioorganic & Medicinal Chemistry, 2002, Janik, Mark E.; Bane, Susan L.
Benzamides and benzamidines as specific inhibitors of epidermal growth factor receptor and v-Src protein tyrosine kinases
score: 1.7538199, Bioorganic & Medicinal Chemistry, 2004, Asano, Toru et. al.
A very simple synthesis of GlcNAc-α-pyrophosphoryl-decanol: A substrate for the assay of a bacterial galactosyltransferase
score: 1.7536896, Bioorganic & Medicinal Chemistry Letters, 2008, Brockhausen, Inka; Larsson, E. Andreas; Hindsgaul, Ole
Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
score: 1.7536706, Bioorganic & Medicinal Chemistry Letters, 2012, Mohan, Sahoo Biswa et. al.
Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
score: 1.7536706, Bioorganic & Medicinal Chemistry Letters, 2012, Mohan, Sahoo Biswa et. al.
Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
score: 1.7536706, Bioorganic & Medicinal Chemistry Letters, 2012, Mohan, Sahoo Biswa et. al.
Synthesis and Antitumor Evaluation of Novel Benzo[d]pyrrolo[2,1-b]thiazole Derivatives
score: 1.753623, European Journal of Medicinal Chemistry, 2012, Chaniyara, Ravi et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.753398, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
score: 1.752382, Bioorganic & Medicinal Chemistry Letters, 2012, Yen, Chiao-Ting et. al.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
score: 1.752382, Bioorganic & Medicinal Chemistry Letters, 2012, Yen, Chiao-Ting et. al.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
score: 1.752382, Bioorganic & Medicinal Chemistry Letters, 2012, Yen, Chiao-Ting et. al.
Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI)
score: 1.7521121, Bioorganic & Medicinal Chemistry, 2005, Bondebjerg, Jon et. al.
Synthesis of a BSA-Le x glycoconjugate and recognition of Le x analogues by the anti-Le x monoclonal antibody SH1: The identification of a non-cross reactive analogue
score: 1.7519096, Bioorganic & Medicinal Chemistry, 2010, Wang, Jo-Wen; Asnani, Ari; Auzanneau, France-Isabelle
Discovery of XL413, a potent and selective CDC7 inhibitor
score: 1.7517568, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
score: 1.7515503, Bioorganic & Medicinal Chemistry Letters, 2012, Phothongkam, Supannee et. al.
Hybrid stereoisomers of a compact molecular probe based on a jasmonic acid glucoside: Syntheses and biological evaluations
score: 1.7512475, Bioorganic & Medicinal Chemistry, 2012, Ueda, Minoru et. al.
Synthesis and structural study of cyclic 5-aminovaleric acid-linked β-Ala–β-Ala dipeptides
score: 1.7512425, Bioorganic & Medicinal Chemistry Letters, 2008, Mengel, Anne; Reiser, Oliver; Aubé, Jeffrey
Structure–activity relationships for 1′,1′-dimethylalkyl-Δ 8-tetrahydrocannabinols
score: 1.7510097, Bioorganic & Medicinal Chemistry, 2003, Huffman, John W et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7507369, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Synthesis and anticancer activity of benzyloxybenzaldehyde derivatives against HL-60 cells
score: 1.7507164, Bioorganic & Medicinal Chemistry, 2005, Lin, Chin-Fen et. al.
Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues
score: 1.7507123, Bioorganic & Medicinal Chemistry, 2005, Silva, Alexandre G. et. al.
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands
score: 1.7506894, European Journal of Medicinal Chemistry, 2012, Gembus, Vincent et. al.
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors
score: 1.7506735, Bioorganic & Medicinal Chemistry, 2012, Zuo, Miao et. al.
Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)
score: 1.7506178, Bioorganic & Medicinal Chemistry Letters, 2013, Martínez-Botella, Gabriel et. al.
Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases
score: 1.7504264, Bioorganic & Medicinal Chemistry Letters, 2012, Plé, Patrick A. et. al.
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
score: 1.7503542, European Journal of Medicinal Chemistry, 2012, Zhang, Lei et. al.
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
score: 1.7503542, European Journal of Medicinal Chemistry, 2012, Zhang, Lei et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.7503292, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds.
score: 1.7503124, Antimicrobial agents and chemotherapy, 2004, Cushion, Melanie T et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7501797, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7501797, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7501797, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
Synthesis and evaluation of a 99mTc-BAT-phenylbenzothiazole conjugate as a potential in vivo tracer for visualization of amyloid β
score: 1.7501668, Bioorganic & Medicinal Chemistry Letters, 2007, Serdons, K. et. al.
Parallel solid-phase synthesis of vitronectin receptor (αvβ3) inhibitors
score: 1.750082, Bioorganic & Medicinal Chemistry Letters, 2000, Gopalsamy, Ariamala et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7500251, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7500251, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Synthesis and evaluation of N1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
score: 1.7500251, Bioorganic & Medicinal Chemistry, 2012, Pérez, Edwin G. et. al.
Structure-based design, synthesis, and in vitro assay of novel nucleoside analog inhibitors against HIV-1 reverse transcriptase
score: 1.7499348, Bioorganic & Medicinal Chemistry Letters, 2005, Liu, Xianjun; Xie, Wei; Huang, Raven H.
A structure–activity study of spermicidal and anti-HIV properties of hydroxylated cationic surfactants
score: 1.7497662, Bioorganic & Medicinal Chemistry, 2002, Wong, Yue-Ling et. al.
Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors
score: 1.749681, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Kai et. al.
The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment
score: 1.749571, European Journal of Medicinal Chemistry, 2012, Kantsadi, A.L. et. al.
Synthesis of indolylalkoxyiminoalkylcarboxylates as leukotriene biosynthesis inhibitors
score: 1.7495633, Bioorganic & Medicinal Chemistry, 1997, Kolasa, Teodozyj et. al.
Heterocyclic rimantadine analogues with antiviral activity
score: 1.7494542, Bioorganic & Medicinal Chemistry, 2003, Stamatiou, George et. al.
Synthesis of novel cyclic NGR/RGD peptide analogs via on resin click chemistry
score: 1.7494139, Bioorganic & Medicinal Chemistry Letters, 2010, Metaferia, Belhu B. et. al.
Synthesis and antitumor activity of formononetin nitrogen mustard derivatives
score: 1.7493666, European Journal of Medicinal Chemistry, 2012, Ren, Jie et. al.
A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
score: 1.7492363, European Journal of Medicinal Chemistry, 2012, Venkateswararao, Eeda et. al.
Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA A receptor complex
score: 1.7490575, Bioorganic & Medicinal Chemistry, 2001, Marder, Mariel et. al.
Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives
score: 1.7487761, Bioorganic & Medicinal Chemistry Letters, 2012, Saito, Yoshio et. al.
Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives
score: 1.7487219, European Journal of Medicinal Chemistry, 2013, Shakil, N.A. et. al.
Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives
score: 1.7487219, European Journal of Medicinal Chemistry, 2013, Shakil, N.A. et. al.
Facile synthesis of novel mutual derivatives of nucleosides and pyrimidines by regioselectively chemo-enzymatic protocol
score: 1.748716, Bioorganic & Medicinal Chemistry, 2008, Qian, Xueqi; Liu, Bokai; Wu, Qi; Lv, Deshui; Lin, Xian-Fu
Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4
score: 1.7481881, Bioorganic & Medicinal Chemistry Letters, 2012, Bhaskar Kumar, T. et. al.
Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells’ activity
score: 1.7480803, Bioorganic & Medicinal Chemistry, 2006, Tanabe, Takamasa et. al.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 1.7480174, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity
score: 1.7480174, Bioorganic & Medicinal Chemistry, 2012, Beebe, Xenia et. al.
Triazoloamides as potent γ-secretase modulators with reduced hERG liability
score: 1.7479026, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Triazoloamides as potent γ-secretase modulators with reduced hERG liability
score: 1.7479026, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Triazoloamides as potent γ-secretase modulators with reduced hERG liability
score: 1.7479026, Bioorganic & Medicinal Chemistry Letters, 2012, Fischer, Christian et. al.
Synthesis and anticonvulsant evaluation of some new 2-substituted-3-arylpyrido[2,3- d]pyrimidinones
score: 1.7478143, Bioorganic & Medicinal Chemistry, 2004, White, David C. et. al.
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies
score: 1.7476865, Bioorganic & Medicinal Chemistry, 2006, Gerpe, Alejandra et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.7475064, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
Synthesis and biological activity of N, N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives
score: 1.7473237, Bioorganic & Medicinal Chemistry, 2006, Braña, Miguel F. et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Identification of novel mPGES-1 inhibitors through screening of a chemical library
score: 1.7471463, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sung-Jun et. al.
Synthesis and antiproliferative activity of basic thioanalogues of merbarone
score: 1.7468123, Bioorganic & Medicinal Chemistry, 2003, Ranise, Angelo et. al.
Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates
score: 1.7467866, Bioorganic & Medicinal Chemistry, 2008, Fujita, Yoshio et. al.
Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues
score: 1.7464766, Bioorganic & Medicinal Chemistry, 2006, Aoyagi, Yutaka et. al.
6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents
score: 1.7464622, Bioorganic & Medicinal Chemistry, 2006, Lin, Chun-Mao et. al.
Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives
score: 1.7464499, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives
score: 1.7464499, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives
score: 1.7464499, European Journal of Medicinal Chemistry, 2012, Vertuani, Silvia et. al.
Pyrenyldiazomethane, a versatile reagent for nucleotide phosphate alkylation
score: 1.7459961, Bioorganic & Medicinal Chemistry Letters, 2005, Kotera, Mitsuharu et. al.
Synthesis of highly water-soluble fibrate derivatives via BGLation
score: 1.7458258, Bioorganic & Medicinal Chemistry Letters, 2012, Nemoto, Hisao et. al.
Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies
score: 1.7455564, Bioorganic & Medicinal Chemistry Letters, 2010, Sun, Chuanwen et. al.
Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogues of quercetin as thrombin inhibitors
score: 1.7454353, European Journal of Medicinal Chemistry, 2012, Shi, Zhi-Hao et. al.
Structure–activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators
score: 1.745419, Bioorganic & Medicinal Chemistry, 2013, Mita, Yusuke et. al.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
score: 1.7453726, Antimicrobial agents and chemotherapy, 2012, Summa, Vincenzo et. al.
Identification of optimum computational protocols for modeling the aryl hydrocarbon receptor (AHR) and its interaction with ligands
score: 1.7451736, Bioorganic & Medicinal Chemistry Letters, 2010, Jogalekar, Ashutosh S.; Reiling, Stephan; Vaz, Roy J.
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold
score: 1.7450956, Bioorganic & Medicinal Chemistry, 2012, Morera, Ludovica et. al.
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold
score: 1.7450956, Bioorganic & Medicinal Chemistry, 2012, Morera, Ludovica et. al.
Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine receptor
score: 1.7450436, Bioorganic & Medicinal Chemistry, 2012, Nishiwaki, Hisashi et. al.
Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine receptor
score: 1.7450436, Bioorganic & Medicinal Chemistry, 2012, Nishiwaki, Hisashi et. al.
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1 H-pyrazolo[3,4- d]pyrimidines 4-amino substituted and their biological evaluation
score: 1.7450378, European Journal of Medicinal Chemistry, 2004, Schenone, Silvia et. al.
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists
score: 1.7449327, Bioorganic & Medicinal Chemistry, 2013, Yamamoto, Satoshi et. al.
Three-Dimensional molecular-Field analyses of octopaminergic agonists for the cockroach neuronal octopamine receptor
score: 1.7447733, Bioorganic & Medicinal Chemistry, 2003, Hirashima, Akinori et. al.
Discovery of XL413, a potent and selective CDC7 inhibitor
score: 1.7445099, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Discovery of XL413, a potent and selective CDC7 inhibitor
score: 1.7445099, Bioorganic & Medicinal Chemistry Letters, 2012, Koltun, Elena S. et. al.
Synthesis and transfecting properties of a glycosylated polycationic DNA vector 1
score: 1.7443442, Bioorganic & Medicinal Chemistry Letters, 2001, Jacopin, Christophe et. al.
Synthesis and anti-inflammatory evaluations of β-lapachone derivatives
score: 1.7442966, Bioorganic & Medicinal Chemistry, 2013, Tseng, Chih-Hua et. al.
Synthesis, biological evaluation, and molecular docking studies of Benzyl, Alkyl and Glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as Potential Immunomodulatory and Immunosuppressive Agents
score: 1.7440921, Bioorganic & Medicinal Chemistry, 2012, El Ashry, El Sayed H. et. al.
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation
score: 1.7440066, Bioorganic & Medicinal Chemistry Letters, 2012, Radi, Marco et. al.
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease
score: 1.743777, Bioorganic & Medicinal Chemistry Letters, 2012, Al-Baghdadi, Osamah et. al.
Synthesis, characterization, and anticonvulsant activity of enaminones. Part 5: Investigations on 3-carboalkoxy-2-methyl-2,3-dihydro-1 H-phenothiazin-4[10 H]-one derivatives
score: 1.7436662, Bioorganic & Medicinal Chemistry, 1998, Laws, Mia L. et. al.
5 H-Dibenzo[ c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-Targeting anticancer agents with potent cytotoxic activity
score: 1.7435935, Bioorganic & Medicinal Chemistry, 2003, Ruchelman, Alexander L. et. al.
Natural Products as a Gold Mine for Selective Matrix Metalloproteinases Inhibitors
score: 1.7435315, Bioorganic & Medicinal Chemistry, 2012, Wang, Liyan et. al.
Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity
score: 1.7433938, European Journal of Medicinal Chemistry, 2012, Skiba, Joanna et. al.
Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity
score: 1.7433938, European Journal of Medicinal Chemistry, 2012, Skiba, Joanna et. al.
The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis x
score: 1.7432352, Bioorganic & Medicinal Chemistry, 1998, Murphy, Paul V. et. al.
Design, synthesis, and evaluation of novel 2-substituted-4-aryl-6,7,8,9-tetrahydro-5 H-pyrimido[4,5- b][1,5]oxazocin-5-ones as NK 1 antagonists
score: 1.7429219, Bioorganic & Medicinal Chemistry, 2005, Seto, Shigeki; Tanioka, Asao; Ikeda, Makoto; Izawa, Shigeru
Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with β-secretase
score: 1.7428934, Bioorganic & Medicinal Chemistry, 2005, Zuo, Zhili et. al.
Prediction of oral bioavailability by adaptive fuzzy partitioning
score: 1.7428858, European Journal of Medicinal Chemistry, 2003, Pintore, Marco et. al.
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
score: 1.7427573, Bioorganic & Medicinal Chemistry, 2012, Misawa, Takashi et. al.
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
score: 1.7427573, Bioorganic & Medicinal Chemistry, 2012, Misawa, Takashi et. al.
Microwave-assisted synthesis of antimicrobial dihydropyridines and tetrahydropyrimidin-2-ones: Novel compounds against aspergillosis
score: 1.7426504, Bioorganic & Medicinal Chemistry, 2006, Chhillar, Anil K. et. al.
Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V 1A receptor
score: 1.7426284, Bioorganic & Medicinal Chemistry, 2006, Shimada, Yoshiaki et. al.
Synthesis, crystal structures, in vitro biological evaluation of zinc(II) and bismuth(III) complexes of 2-acetylpyrazine N(4)-phenylthiosemicarbazone
score: 1.7426184, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Ming-Xue et. al.
Rotational deviation of 3-acetyl group from cyclic tetrapyrrole π-plane in synthetic bacteriochlorophyll- a analogs by 20-substitution
score: 1.7425295, Bioorganic & Medicinal Chemistry Letters, 2008, Tamiaki, Hitoshi; Kotegawa, Yuki; Mizutani, Keisuke
Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase
score: 1.7425107, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, In-Hae et. al.
Efficient approach to acyloxymethyl esters of nalidixic acid and in vitro evaluation as intra-ocular prodrugs
score: 1.7423895, Bioorganic & Medicinal Chemistry, 2006, Azéma, Joëlle et. al.
Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells
score: 1.7423199, Bioorganic & Medicinal Chemistry Letters, 2013, Miyata, Yoshiki et. al.
Synthesis and antifungal activity of substituted-10-methyl-1,2,3,4-tetrahydropyrazino[1,2- a]indoles
score: 1.7420433, Bioorganic & Medicinal Chemistry, 2006, Tiwari, Rakesh Kumar et. al.
Synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers
score: 1.7419054, Bioorganic & Medicinal Chemistry, 1998, Takahashi, Tadakatsu et. al.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
score: 1.7417264, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
score: 1.7417264, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
score: 1.7417264, Bioorganic & Medicinal Chemistry Letters, 2012, Labadie, Sharada et. al.
Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives
score: 1.7416602, Bioorganic & Medicinal Chemistry, 2004, Mäntylä, Antti et. al.
Design, syntheses, and biological evaluations of squamostolide and its related analogs
score: 1.7414614, Bioorganic & Medicinal Chemistry, 2005, Lee, Cheng-Lin et. al.
New potential biologically active compounds: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1 H,3 H)-diones under microwave irradiation
score: 1.741267, Bioorganic & Medicinal Chemistry Letters, 2006, Tu, Shujiang et. al.
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain
score: 1.7409225, Bioorganic & Medicinal Chemistry Letters, 2012, Jiao, Guan-Sheng et. al.
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
score: 1.7407764, Bioorganic & Medicinal Chemistry Letters, 2012, Suchaud, Virginie et. al.
Novel retinoid X receptor (RXR) antagonists having a dicarba- closo-dodecaborane as a hydrophobic moiety
score: 1.7406401, Bioorganic & Medicinal Chemistry Letters, 2004, Ohta, Kiminori et. al.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
score: 1.7404964, Bioorganic & Medicinal Chemistry Letters, 2012, Rodriguez, Alice L. et. al.
Synthesis and bioactivity of 2,4-diacyl analogues of paclitaxel
score: 1.7404115, Bioorganic & Medicinal Chemistry, 2001, Chordia, Mahendra D et. al.
Sulfonamide bearing oligonucleotides: Simple synthesis and efficient RNA recognition
score: 1.7403514, Bioorganic & Medicinal Chemistry, 2012, Kumar, Pawan et. al.
Challenges of antibacterial discovery.
score: 1.7403377, Clinical microbiology reviews, 2011, Silver, Lynn L
Prediction of intrinsic solubility of generic drugs using MLR, ANN and SVM analyses
score: 1.7400191, European Journal of Medicinal Chemistry, 2010, Louis, Bruno; Agrawal, Vijay K.; Khadikar, Padmakar V.
Synthesis and in vitro antitubercular activity of 4-aryl/alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis
score: 1.7398626, Bioorganic & Medicinal Chemistry Letters, 2012, Jeyachandran, Malaichamy et. al.
Synthesis and in vitro antitubercular activity of 4-aryl/alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis
score: 1.7398626, Bioorganic & Medicinal Chemistry Letters, 2012, Jeyachandran, Malaichamy et. al.
Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.
score: 1.7395148, Antimicrobial agents and chemotherapy, 2012, Pou, Sovitj et. al.
Design, Synthesis, and Structure-activity Relationships of Novel Spiro-piperidines as Acetyl-CoA Carboxylase Inhibitors
score: 1.73941, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
5-Alkylated thiazolidinones as follicle-stimulating hormone (FSH) receptor agonists
score: 1.7393831, Bioorganic & Medicinal Chemistry, 2006, Wrobel, Jay et. al.
A Facile One-Pot Synthesis of 4,5-Diaryl-2,2-dimethyl-3( 2H)-furanones
score: 1.7381475, Bioorganic & Medicinal Chemistry, 2002, Lee, Ki-Wha et. al.
Discovery of selective, small-molecule inhibitors of RNA complexes—1. The tat protein/TAR RNA complexes required for HIV-1 transcription
score: 1.7379093, Bioorganic & Medicinal Chemistry, 1997, Mei, Houng-Yau et. al.
Conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site
score: 1.737681, Bioorganic & Medicinal Chemistry, 2012, Varvarigou, Nicole et. al.
Conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site
score: 1.737681, Bioorganic & Medicinal Chemistry, 2012, Varvarigou, Nicole et. al.
Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H 37 Rv
score: 1.7374391, Bioorganic & Medicinal Chemistry Letters, 2005, Shindikar, Anand V.; Viswanathan, C.L.
Discovery and preliminary structure–activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds
score: 1.7374143, Bioorganic & Medicinal Chemistry Letters, 2013, Liew, Lydia P.P.; Kaiser, Marcel; Copp, Brent R.
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
score: 1.7373027, Bioorganic & Medicinal Chemistry Letters, 2012, Chapman, Timothy M. et. al.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d] pyrimidine derivatives
score: 1.7370237, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.
score: 1.7369383, Antimicrobial agents and chemotherapy, 2009, Yang, Liang et. al.
Design of β-carboline derivatives as DNA-targeting antitumor agents
score: 1.7367589, European Journal of Medicinal Chemistry, 2006, Guan, Huaji et. al.
Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents
score: 1.736666, Bioorganic & Medicinal Chemistry Letters, 2012, Chae, Eunhee et. al.
Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.
score: 1.7366536, Antimicrobial agents and chemotherapy, 2012, Ke, Wei et. al.
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7366352, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7366352, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides
score: 1.7366352, Bioorganic & Medicinal Chemistry Letters, 2012, Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
score: 1.7366228, Bioorganic & Medicinal Chemistry Letters, 2012, McLean, Larry R. et. al.
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
score: 1.7366228, Bioorganic & Medicinal Chemistry Letters, 2012, McLean, Larry R. et. al.
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
score: 1.7366228, Bioorganic & Medicinal Chemistry Letters, 2012, McLean, Larry R. et. al.
[4-[[ N-(3-Chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors
score: 1.7365832, Bioorganic & Medicinal Chemistry, 2000, Tumiatti, Vincenzo et. al.
Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases
score: 1.7361049, Bioorganic & Medicinal Chemistry, 2004, Götz, Marion G. et. al.
Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties
score: 1.7361013, Bioorganic & Medicinal Chemistry, 2006, Bezerra-Netto, Heleno J.C. et. al.
New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity.
score: 1.7358736, Antimicrobial agents and chemotherapy, 2004, Beyer, Dieter et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Synthesis and biological evaluation of optically active Ki16425
score: 1.7356436, Bioorganic & Medicinal Chemistry Letters, 2012, Sato, Takanao et. al.
Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs
score: 1.7352774, Bioorganic & Medicinal Chemistry Letters, 2009, Simon, Grégory et. al.
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure–activity relationships of neocryptolepines and 6-methyl congeners
score: 1.7352768, Bioorganic & Medicinal Chemistry, 2012, Wang, Li et. al.
Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
score: 1.7350039, Bioorganic & Medicinal Chemistry, 2005, Komoriya, Satoshi et. al.
Synthesis and biological activity of bi/tricyclic azasugars fused thiazolidin-4-one and thiazinan-4-one by microwave-assisted tandem Staudinger/aza-Wittig/cyclization
score: 1.7349016, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Xiaoliu et. al.
QSAR study on some anti-HIV HEPT analogues using physicochemical and topological parameters
score: 1.73485, Bioorganic & Medicinal Chemistry, 2004, Gayen, Shovanlal; Debnath, Bikash; Samanta, Soma; Jha, Tarun
Synthesis and structure–activity relationship of a novel class of 15-membered macrolide antibiotics known as ‘11a-azalides’
score: 1.7344102, Bioorganic & Medicinal Chemistry, 2012, Sugimoto, Tomohiro et. al.
Synthesis of 17β-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines
score: 1.7341463, Bioorganic & Medicinal Chemistry Letters, 2008, Provencher-Mandeville, Josée et. al.
Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity
score: 1.7332916, Bioorganic & Medicinal Chemistry, 2012, Chen, Kuen-Feng et. al.
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol
score: 1.7330355, Bioorganic & Medicinal Chemistry, 2012, Cho, Suengmok et. al.
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
score: 1.7328877, Bioorganic & Medicinal Chemistry Letters, 2012, Bruce, Ian et. al.
A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives.
score: 1.7328424, Antimicrobial agents and chemotherapy, 2011, Burger-Kentischer, Anke et. al.
2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain
score: 1.7327271, Bioorganic & Medicinal Chemistry, 1996, Baillet, Stéphanie et. al.
Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities
score: 1.7326453, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Jian et. al.
Enzymatic syntheses and selective hydrolysis of O-β- d-galactopyranosides using a marine mollusc β-galactosidase
score: 1.7324055, Bioorganic & Medicinal Chemistry Letters, 2005, Giordano, Assunta et. al.
Cyclic Dibenzoylhydrazines Reproducing the Conformation of Ecdysone Agonists, RH-5849
score: 1.7323749, Bioorganic & Medicinal Chemistry, 2002, Toya, Tetsuya; Yamaguchi, Kentaro; Endo, Yasuyuki
Enamino-oxindole HIV protease inhibitors
score: 1.7322606, Bioorganic & Medicinal Chemistry Letters, 2012, Eissenstat, Michael et. al.
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine.
score: 1.7321772, Antimicrobial agents and chemotherapy, 2000, Bazmi, H Z et. al.
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
score: 1.7321032, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Li et. al.
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
score: 1.7321032, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Li et. al.
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
score: 1.7321032, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Li et. al.
Phosphoramidate and phosphate prodrugs of (−)-β- d-(2 R,4 R)-dioxolane-thymine: Synthesis, anti-HIV activity and stability studies
score: 1.7320537, Bioorganic & Medicinal Chemistry, 2006, Liang, Yuzeng et. al.
Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid
score: 1.7318834, Bioorganic & Medicinal Chemistry Letters, 2009, Cao, Hongzhi et. al.
Design, syntheses, and structure–Activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads
score: 1.7316211, Bioorganic & Medicinal Chemistry, 2001, Morimoto, Hiroshi et. al.
Efficient synthesis and biological evaluation of all a-ring diastereomers of 1α,25-dihydroxyvitamin D 3 and its 20-epimer
score: 1.7313557, Bioorganic & Medicinal Chemistry, 2000, Fujishima, Toshie et. al.
Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives
score: 1.7309929, European Journal of Medicinal Chemistry, 2012, Maggio, B. et. al.
Enamino-oxindole HIV protease inhibitors
score: 1.730979, Bioorganic & Medicinal Chemistry Letters, 2012, Eissenstat, Michael et. al.
Synthesis and structure–activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells
score: 1.730779, Bioorganic & Medicinal Chemistry, 2002, Ogita, Haruhisa et. al.
Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: potential PET imaging agents for tumor detection
score: 1.7306093, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yurong et. al.
Design, synthesis and evaluation of a series of novel fumagillin analogues
score: 1.7305023, Bioorganic & Medicinal Chemistry, 2003, Fardis, Maria et. al.
Synthesis and antiproliferative activity of some new DNA-targeted alkylating pyrroloquinolines
score: 1.7304777, Bioorganic & Medicinal Chemistry, 2004, Ferlin, M.G.; Dalla Via, L.; Gia, O.M.
Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies
score: 1.7304315, Bioorganic & Medicinal Chemistry Letters, 2010, Niu, Chuansheng et. al.
Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents
score: 1.7302352, Bioorganic & Medicinal Chemistry, 2005, Agarwal, Anu et. al.
Alkylation of succinates: Synthesis of Ro 32–3555
score: 1.7302244, Bioorganic & Medicinal Chemistry Letters, 1998, McClure, Kim F.; Axt, Matthew Z.
Recent advances in the biology and chemistry of the flavaglines
score: 1.7300409, Bioorganic & Medicinal Chemistry, 2012, Ribeiro, Nigel et. al.
Synthesis of highly functionalised dibenzylglycine derivatives via the Suzuki–Miyaura coupling reaction
score: 1.7299596, Bioorganic & Medicinal Chemistry Letters, 2002, Kotha, Sambasivarao et. al.
Diphenyl quinolines and isoquinolines: synthesis and primary biological evaluation
score: 1.7298111, Bioorganic & Medicinal Chemistry, 2000, Croisy-Delcey, Martine et. al.
N-Terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding
score: 1.7297585, Bioorganic & Medicinal Chemistry, 2001, Burke Jr, Terrence R et. al.
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives
score: 1.729748, European Journal of Medicinal Chemistry, 2012, Kotaiah, Y.; Harikrishna, N.; Nagaraju, K.; Venkata Rao, C.
Synthesis and in vitro and in vivo anticancer activity of novel 3-methyl-5H-isoxazolo[5′,4′:5,6]pyrido[2,3-b]indoles
score: 1.7296662, Bioorganic & Medicinal Chemistry Letters, 2012, Rajanarendar, E. et. al.
Conformationally restricted novel pyrazole derivatives: Synthesis of 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles as a new class of PDE4 inhibitors
score: 1.7293046, Bioorganic & Medicinal Chemistry Letters, 2012, Shyamsunder Reddy, T. et. al.
Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation
score: 1.7292725, Bioorganic & Medicinal Chemistry, 2008, Obika, Satoshi et. al.
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
score: 1.7291149, Bioorganic & Medicinal Chemistry Letters, 2013, Le, Uyen et. al.
Synthesis and biological activity of β-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT
score: 1.7288976, Bioorganic & Medicinal Chemistry, 1997, de Bont, Dries B.A. et. al.
Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes
score: 1.7287752, Bioorganic & Medicinal Chemistry, 2005, Goto, Tokuhito et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.7285756, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
Termination of the structural confusion between plipastatin A1 and fengycin IX
score: 1.7285756, Bioorganic & Medicinal Chemistry, 2012, Honma, Miho et. al.
QSAR modeling of HIV-1 reverse transcriptase inhibitor 2-amino-6-arylsulfonylbenzonitriles and congeners using molecular connectivity and E-state parameters
score: 1.7285185, Bioorganic & Medicinal Chemistry, 2004, Roy, Kunal; Leonard, J.Thomas
Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moiety
score: 1.7283298, Bioorganic & Medicinal Chemistry Letters, 2012, Animati, Fabio et. al.
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
score: 1.7281427, Bioorganic & Medicinal Chemistry, 2012, Kambe, Tohru et. al.
Synthesis of C-6 substituted pyrazolo[1,5- a]pyridines with potent activity against herpesviruses
score: 1.7279722, Bioorganic & Medicinal Chemistry, 2006, Allen, Scott H. et. al.
Structure–activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists
score: 1.727968, Bioorganic & Medicinal Chemistry, 2012, Rikimaru, Kentaro et. al.
A Convenient Synthetic Method of a 5,7-Diarylcyclopenteno-[1,2- b]pyridine-6-carboxylate: A Key Intermediate for Potent Endothelin Receptor Antagonists
score: 1.7276333, Bioorganic & Medicinal Chemistry, 2002, Niiyama, Kenji et. al.
Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents
score: 1.7275987, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents
score: 1.7275987, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents
score: 1.7275987, European Journal of Medicinal Chemistry, 2012, Tarleton, Mark et. al.
Novel iodine-124 labeled EGFR inhibitors as potential PET agents for molecular imaging in cancer
score: 1.7275466, Bioorganic & Medicinal Chemistry, 2004, Shaul, Mazal et. al.
Discovery of small molecule HIV-1 integrase dimerization inhibitors
score: 1.7272727, Bioorganic & Medicinal Chemistry Letters, 2012, Tintori, Cristina et. al.
Discovery of small molecule HIV-1 integrase dimerization inhibitors
score: 1.7272727, Bioorganic & Medicinal Chemistry Letters, 2012, Tintori, Cristina et. al.
Discovery of small molecule HIV-1 integrase dimerization inhibitors
score: 1.7272727, Bioorganic & Medicinal Chemistry Letters, 2012, Tintori, Cristina et. al.
Progress in arylpiperazine synthesis by the catalytic amination reaction
score: 1.7271967, Bioorganic & Medicinal Chemistry, 2002, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
score: 1.7269969, Bioorganic & Medicinal Chemistry, 2012, Wang, Yan-Xiang et. al.
Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
score: 1.7269969, Bioorganic & Medicinal Chemistry, 2012, Wang, Yan-Xiang et. al.
Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
score: 1.7269969, Bioorganic & Medicinal Chemistry, 2012, Wang, Yan-Xiang et. al.
In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.
score: 1.7269661, Antimicrobial agents and chemotherapy, 2011, Leeds, J A et. al.
Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors
score: 1.7267593, European Journal of Medicinal Chemistry, 2012, Hao, Lan-hu et. al.
Design, synthesis and molecular docking studies of sinomenine derivatives
score: 1.7266616, Bioorganic & Medicinal Chemistry Letters, 2012, Chai, Xiaoyun et. al.
Enantioselective synthesis of derivatives and structure–activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent
score: 1.7265523, Bioorganic & Medicinal Chemistry Letters, 2013, Kawasaki, Ken-ichi et. al.
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives
score: 1.7262132, Bioorganic & Medicinal Chemistry, 2005, Nakagawa-Goto, Kyoko et. al.
Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide
score: 1.7261763, European Journal of Medicinal Chemistry, 2012, Deslandes, Sébastien et. al.
A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A 2
score: 1.725854, European Journal of Medicinal Chemistry, 2001, Bernard, Philippe et. al.
Novel matrix metalloproteinase inhibitors: Generation of lead compounds by the in silico fragment-based approach
score: 1.7256226, Bioorganic & Medicinal Chemistry, 2005, Takahashi, Kanji et. al.
Synthesis and preliminary biological evaluation of β-carotene and retinoic acid oxidation products
score: 1.725545, Bioorganic & Medicinal Chemistry, 2006, Kithsiri Wijeratne, E.M. et. al.
Synthesis and Evaluation of Novel 2-Pyridone Derivatives as Inhibitors of Phosphodiestarase3 (PDE3): A Target for Heart Failure and Platelet Aggregation
score: 1.7255213, Bioorganic & Medicinal Chemistry Letters, 2012, Ravinder, Mettu et. al.
Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor
score: 1.7254172, Bioorganic & Medicinal Chemistry, 2004, Xu, Yong et. al.
Synthesis and cytotoxic activity of lipophilic sulphonamide derivatives of the benzo[ b]thiophene 1,1-dioxide
score: 1.7252735, Bioorganic & Medicinal Chemistry, 2004, Villar, R. et. al.
Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416
score: 1.7252103, Bioorganic & Medicinal Chemistry, 2006, Pandit, Bulbul et. al.
Non-Natural glycosphingolipids and structurally simpler analogues bind HIV-1 recombinant Gp120
score: 1.7249328, Bioorganic & Medicinal Chemistry, 2002, McReynolds, Katherine D et. al.
Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation
score: 1.7249264, European Journal of Medicinal Chemistry, 2012, Shi, Liqiao et. al.
Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana
score: 1.7247321, Bioorganic & Medicinal Chemistry, 2005, Liaw, Chih-Chuang et. al.
Synthesis and in vitro leishmanicidal activity of some hydrazides and their analogues
score: 1.7244023, Bioorganic & Medicinal Chemistry, 2003, Khan, Khalid Mohammad et. al.
Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity
score: 1.724217, European Journal of Medicinal Chemistry, 2005, Kettler, Katja et. al.
A practical synthesis of 3-[(1 R)-1- t-butyldimethylsilyloxyethyl]-4-[(2 R)-4-halo-3-oxo-2-butyl]azetidinone, a versatile intermediate for carbapenem antibiotics
score: 1.7237923, Bioorganic & Medicinal Chemistry Letters, 1998, Yang, Chunhua; Yasuda, Nobuyoshi
The methymycin/pikromycin pathway: A model for metabolic diversity in natural product biosynthesis
score: 1.7236164, Bioorganic & Medicinal Chemistry, 2009, Kittendorf, Jeffrey D.; Sherman, David H.
Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease
score: 1.7234004, Bioorganic & Medicinal Chemistry, 1998, Badia, Albert et. al.
In silico prediction of central nervous system activity of compounds. Identification of potential pharmacophores by the TOPS–MODE approach
score: 1.7233915, Bioorganic & Medicinal Chemistry, 2004, Cabrera Pérez, Miguel Angel; Sanz, Marival Bermejo
Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)coumarins
score: 1.723167, European Journal of Medicinal Chemistry, 2004, Di Braccio, Mario et. al.
Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
score: 1.7228928, Bioorganic & Medicinal Chemistry Letters, 2012, Yadlapalli, Rama Krishna et. al.
Design, synthesis, and α 1-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion
score: 1.7226708, Bioorganic & Medicinal Chemistry, 2004, Betti, Laura et. al.
Photoactivated DNA cleavage and anticancer activity of pyrenyl-terpyridine lanthanide complexes
score: 1.7225919, European Journal of Medicinal Chemistry, 2012, Hussain, Akhtar et. al.
Molecular docking study and development of an empirical binding free energy model for phosphodiesterase 4 inhibitors
score: 1.7225258, Bioorganic & Medicinal Chemistry, 2006, Oliveira, Fernanda G. et. al.
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents
score: 1.7224119, Bioorganic & Medicinal Chemistry, 2003, Brouillette, Wayne J et. al.
Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists
score: 1.7220606, Bioorganic & Medicinal Chemistry, 2004, Rijkers, Dirk T.S.; den Hartog, Jack A.J.; Liskamp, Rob M.J.
Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry
score: 1.7219639, Bioorganic & Medicinal Chemistry Letters, 2012, Rivara, Mirko et. al.
New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7β-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3′
score: 1.7217055, Bioorganic & Medicinal Chemistry, 2004, Yoshizawa, Hidenori et. al.
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
score: 1.7214219, European Journal of Medicinal Chemistry, 2013, Chuck, Chi-Pang et. al.
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
score: 1.7214219, European Journal of Medicinal Chemistry, 2013, Chuck, Chi-Pang et. al.
Discovery of a new class of ghrelin receptor antagonists
score: 1.7211588, Bioorganic & Medicinal Chemistry Letters, 2012, Mihalic, Jeffrey T. et. al.
Quinazolines as adenosine receptor antagonists: SAR and selectivity for A 2B receptors
score: 1.7210622, Bioorganic & Medicinal Chemistry, 2003, Webb, Thomas R et. al.
Synthesis and anti-HIV activity of 1,1,3-trioxo-2 H,4 H-thieno[3,4- e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors
score: 1.7208712, Bioorganic & Medicinal Chemistry, 1999, Arranz, M et. al.
Tridemethylisovelleral, a potent cytotoxic agent
score: 1.7207769, Bioorganic & Medicinal Chemistry, 2005, Aujard, Isabelle et. al.
Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design
score: 1.7206604, Bioorganic & Medicinal Chemistry Letters, 2005, Basak, Amit; Kar, Moumita; Mandal, Subrata
Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration
score: 1.720052, Bioorganic & Medicinal Chemistry Letters, 2013, Ochiai, Koji et. al.
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
score: 1.7200454, Bioorganic & Medicinal Chemistry Letters, 2012, Rzasa, Robert M. et. al.
Regioselective and stereospecific cleavage of a terminal oxirane system: A novel synthetic approach to lipid mediator congeners—1,2(2,3)-diacyl-3(1)-halo- sn-glycerols
score: 1.7200011, Bioorganic & Medicinal Chemistry Letters, 2006, Stamatov, Stephan D.; Stawinski, Jacek
Fluorescent ligands for adenosine receptors
score: 1.7195468, Bioorganic & Medicinal Chemistry Letters, 2013, Kozma, Eszter et. al.
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: Synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities
score: 1.7194102, European Journal of Medicinal Chemistry, 2012, Kaur, Kirandeep et. al.
Synthesis of 1-(ω-aminoalkyl)naphthoindolediones with antiproliferative properties
score: 1.7193217, Bioorganic & Medicinal Chemistry, 2004, Shchekotikhin, Andrey E et. al.
Organometallic ruthenium(II) complexes: Synthesis, structure and influence of substitution at azomethine carbon towards DNA/BSA binding, radical scavenging and cytotoxicity
score: 1.7193103, European Journal of Medicinal Chemistry, 2012, Sathyadevi, Palanisamy et. al.
Analogs of 1α,25-dihydroxyvitamin D 3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: Synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs
score: 1.719167, Bioorganic & Medicinal Chemistry, 2006, Shimazaki, Mika et. al.
Analogues of antifungal tjipanazoles from rebeccamycin
score: 1.7191598, Bioorganic & Medicinal Chemistry, 2004, Voldoire, Aline et. al.
Enamino-oxindole HIV protease inhibitors
score: 1.7190405, Bioorganic & Medicinal Chemistry Letters, 2012, Eissenstat, Michael et. al.
Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
score: 1.7188418, Bioorganic & Medicinal Chemistry Letters, 2012, Emmadi, Narender Reddy et. al.
Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
score: 1.7188418, Bioorganic & Medicinal Chemistry Letters, 2012, Emmadi, Narender Reddy et. al.
Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
score: 1.7188418, Bioorganic & Medicinal Chemistry Letters, 2012, Emmadi, Narender Reddy et. al.
Selective non-lipid modulator of LPA5 activity in human platelets
score: 1.7188063, Bioorganic & Medicinal Chemistry Letters, 2012, Kozian, Detlef H. et. al.
Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: inhibitors of leukotriene B 4 1 NCL Communication No. 6453. 1
score: 1.7188007, Bioorganic & Medicinal Chemistry, 1999, Deshpande, Anil M. et. al.
Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives
score: 1.7183184, Bioorganic & Medicinal Chemistry, 2006, Chen, Yeh-Long et. al.
Targeting the α-folate receptor with cyclopenta[ g]quinazoline-based inhibitors of thymidylate synthase
score: 1.7182974, Bioorganic & Medicinal Chemistry, 2006, Henderson, Elisa A. et. al.
Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents
score: 1.7182482, Bioorganic & Medicinal Chemistry Letters, 2010, Wang, Limin et. al.
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
score: 1.7179947, European Journal of Medicinal Chemistry, 2012, Sahu, Pramod K. et. al.
Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds
score: 1.717985, Bioorganic & Medicinal Chemistry, 2003, Dardonville, Christophe et. al.
Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure–activity relationships of phenylpiperazine derivatives
score: 1.7177778, Bioorganic & Medicinal Chemistry, 2006, Takahashi, Toshiyuki et. al.
Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity
score: 1.7176179, Bioorganic & Medicinal Chemistry, 1999, Baraldi, Pier Giovanni et. al.
Inhibition of secretory phospholipase A 2. 2-Synthesis and structure–activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4 H-oxadiazol-5-one ( PMS1062) derivatives specific for group II enzyme
score: 1.7175425, Bioorganic & Medicinal Chemistry, 2005, Dong, Chang-Zhi et. al.
Parallel synthesis and biological activity of a new class of high affinity and selective δ-opioid ligand
score: 1.717535, Bioorganic & Medicinal Chemistry, 2001, Barn, D.R. et. al.
New styryl sulfones as anticancer agents
score: 1.716621, European Journal of Medicinal Chemistry, 2003, Vedula, Manohar Sharma et. al.
The design and synthesis of a potent angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone angiotensin II
score: 1.7165264, Bioorganic & Medicinal Chemistry, 2000, Matsoukas, John M. et. al.
The synthesis and antibacterial activity of totarol derivatives. part 3: modification of ring-B
score: 1.7164844, Bioorganic & Medicinal Chemistry, 2000, Evans, Gary B et. al.
Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents
score: 1.7164056, European Journal of Medicinal Chemistry, 2012, Song, Ming-Xia et. al.
Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents
score: 1.7164056, European Journal of Medicinal Chemistry, 2012, Song, Ming-Xia et. al.
Synthesis and in vitro muscarinic activities of a series of 3-(pyrazol-3-yl)-1-azabicyclo[2.2.2]octanes
score: 1.7163679, Bioorganic & Medicinal Chemistry, 2000, Plate, Ralf et. al.
The antioxidant effect of imine resveratrol analogues
score: 1.7162141, Bioorganic & Medicinal Chemistry Letters, 2012, Lu, Jing et. al.
Facile synthesis of cyclopeptide-centered multivalent glycoclusters with ‘click chemistry’ and molecular recognition study by surface plasmon resonance
score: 1.7162069, Bioorganic & Medicinal Chemistry Letters, 2009, Chen, Yong-Xiang et. al.
Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives
score: 1.716197, Bioorganic & Medicinal Chemistry, 2004, Zhu, Xiao-Kang et. al.
Design, synthesis and in vitro characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta cell imaging by SPECT
score: 1.7160669, Bioorganic & Medicinal Chemistry, 2010, Behnam Azad, Babak et. al.
Mechanisms of trovafloxacin hepatotoxicity: Studies of a model cyclopropylamine-containing system
score: 1.7159421, Bioorganic & Medicinal Chemistry Letters, 2007, Sun, Qin; Zhu, Ran; Foss, Frank W.; Macdonald, Timothy L.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
score: 1.7156554, Bioorganic & Medicinal Chemistry, 2012, Chobanian, Harry R. et. al.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
score: 1.7156554, Bioorganic & Medicinal Chemistry, 2012, Chobanian, Harry R. et. al.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
score: 1.7154049, Bioorganic & Medicinal Chemistry Letters, 2012, Chiba, Takashi et. al.
1,5-Benzodiazepines
score: 1.715385, European Journal of Medicinal Chemistry, 2002, Grossi, Giancarlo et. al.
Highly solvatochromic fluorescent naphthalimides: Design, synthesis, photophysical properties and fluorescence switch-on sensing of ct-DNA
score: 1.7152496, Bioorganic & Medicinal Chemistry Letters, 2013, Bag, Subhendu Sekhar et. al.
Structure–activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives
score: 1.7152224, Bioorganic & Medicinal Chemistry, 2005, Darvesh, Sultan et. al.
The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency
score: 1.7151575, European Journal of Medicinal Chemistry, 2002, Peschke, Bernd et. al.
A topological sub-structural approach for predicting human intestinal absorption of drugs
score: 1.7151115, European Journal of Medicinal Chemistry, 2004, Pérez, Miguel Angel Cabrera et. al.
Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.
score: 1.7147012, Antimicrobial agents and chemotherapy, 2005, Zhu, Weimin et. al.
Bacterial siderophores: synthesis and biological activities of novel pyochelin analogues
score: 1.7145726, Bioorganic & Medicinal Chemistry Letters, 2003, Zamri, A; Schalk, I.J; Pattus, F; Abdallah, M.A
Multivariate SAR/QSAR of 3-aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase (FAS) inhibitors
score: 1.714442, European Journal of Medicinal Chemistry, 2010, de Melo, Eduardo Borges
Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents
score: 1.7143729, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Yong et. al.
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors
score: 1.7143437, Bioorganic & Medicinal Chemistry Letters, 2013, Mandadapu, Sivakoteswara Rao et. al.
Targeting the gatekeeper residue in phosphoinositide 3-kinases
score: 1.714316, Bioorganic & Medicinal Chemistry, 2005, Alaimo, Peter J.; Knight, Zachary A.; Shokat, Kevan M.
Synthesis and anticancer evaluation of certain 4-anilinofuro[2,3- b]quinoline and 4-anilinofuro[3,2- c]quinoline derivatives
score: 1.714254, European Journal of Medicinal Chemistry, 2005, Chen, Yeh-Long et. al.
Fragmentation of Golgi membranes by norrisolide and designed analogues
score: 1.714171, Bioorganic & Medicinal Chemistry Letters, 2004, Brady, Thomas P. et. al.
Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines
score: 1.7141262, European Journal of Medicinal Chemistry, 2012, Zheng, Chang-Ji et. al.
Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin.
score: 1.7140808, Antimicrobial agents and chemotherapy, 2003, O'Keefe, Barry R et. al.
The effect of vindoline C-16 substituents on the biomimetic coupling reaction: synthesis and cytotoxicity evalution of the corresponding vinorelbine analogues
score: 1.7140424, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Weibin et. al.
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
score: 1.7140191, Bioorganic & Medicinal Chemistry, 2012, Lang, Karen Luise et. al.
N-Heterocyclic dicarboxylic acids: Broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria
score: 1.7139156, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Lei et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.7138438, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.7138438, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues
score: 1.7138438, Bioorganic & Medicinal Chemistry Letters, 2012, Chakraborty, Saibal et. al.
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor
score: 1.7138144, Bioorganic & Medicinal Chemistry, 2006, Cohen, Sheila M. et. al.
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice
score: 1.7137595, Bioorganic & Medicinal Chemistry, 2012, Kumar, Atul et. al.
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors
score: 1.7135327, Bioorganic & Medicinal Chemistry, 2005, Stöckel-Maschek, Angela et. al.
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring
score: 1.7132817, Bioorganic & Medicinal Chemistry Letters, 2012, Boys, Mark L. et. al.
Baylis–Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
score: 1.712953, Bioorganic & Medicinal Chemistry, 2004, Batra, S. et. al.
Antibacterial activities and characterization of novel inhibitors of LpxC.
score: 1.7128583, Antimicrobial agents and chemotherapy, 2002, Clements, John M et. al.
New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
score: 1.7127245, European Journal of Medicinal Chemistry, 2012, Shah, Nimesh M.; Patel, Manish P.; Patel, Ranjan G.
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation
score: 1.7122434, Bioorganic & Medicinal Chemistry, 2012, Mao, Fei et. al.
Catalytic Pictet–Spengler reactions using Yb(OTf) 3
score: 1.7122371, Bioorganic & Medicinal Chemistry, 2005, Manabe, Kei; Nobutou, Daisuke; Kobayashi, Shū
Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation
score: 1.7121943, European Journal of Medicinal Chemistry, 2012, Abdou, Wafaa M.; Barghash, Reham F.; Sediek, Ashraf A.
Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation
score: 1.7121943, European Journal of Medicinal Chemistry, 2012, Abdou, Wafaa M.; Barghash, Reham F.; Sediek, Ashraf A.
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity
score: 1.7120425, European Journal of Medicinal Chemistry, 2012, Karakurt, Arzu et. al.
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity
score: 1.7120425, European Journal of Medicinal Chemistry, 2012, Karakurt, Arzu et. al.
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity
score: 1.7120425, European Journal of Medicinal Chemistry, 2012, Karakurt, Arzu et. al.
Towards a KCC2 blocker pharmacophore model
score: 1.7117926, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Towards a KCC2 blocker pharmacophore model
score: 1.7117926, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Towards a KCC2 blocker pharmacophore model
score: 1.7117926, Bioorganic & Medicinal Chemistry Letters, 2012, Lebon, Florence et. al.
Selective boron-Containing thrombin inhibitors—X-ray analysis reveals surprising binding mode
score: 1.7117508, Bioorganic & Medicinal Chemistry, 2000, von Matt, Anette et. al.
Synthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT 4 receptor agonists
score: 1.7117446, Bioorganic & Medicinal Chemistry, 2005, Sonda, Shuji et. al.
N-Acyl-1,2,3,4a,5,10b-hexahydro-[1]benzopyrano-[3,4- b][1,4]oxazine-9-carbonitriles as bladder-selective potassium channel openers
score: 1.7116694, Bioorganic & Medicinal Chemistry, 2001, Chiu, Hsin-I. et. al.
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
score: 1.7116674, Bioorganic & Medicinal Chemistry Letters, 2012, Sheffler, Douglas J. et. al.
2-Pyrones possessing antimicrobial and cytotoxic activities
score: 1.7115401, Bioorganic & Medicinal Chemistry, 2004, Fairlamb, Ian J.S et. al.
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues
score: 1.7112991, Bioorganic & Medicinal Chemistry, 2006, Krištafor, Vedran et. al.
Inhibition studies with rationally designed inhibitors of the human low molecular weight protein tyrosine phosphatase
score: 1.711222, Bioorganic & Medicinal Chemistry, 2004, Zabell, Adam P.R et. al.
Synthesis, biological evaluation, and molecular modeling of novel thioacridone derivatives related to the anticancer alkaloid acronycine
score: 1.7110629, Bioorganic & Medicinal Chemistry, 2005, Dheyongera, James P. et. al.
An approach for differentiating isozymes. Construction oflibraries containing short aromatic peptides as part of a method to design selective inhibitors against lipases
score: 1.7107812, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sangeun; Yu, Jaehoon
A prenylbisabolane with NF-κB inhibiting properties from Cascarilla ( Croton eluteria)
score: 1.7107584, Bioorganic & Medicinal Chemistry, 2005, Campagnuolo, Claudio et. al.
Synthesis and evaluation of novel podophyllotoxin analogs
score: 1.7105852, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jie et. al.
Synthesis and evaluation of N1/C4-substituted β-lactams as PPE and HLE inhibitors
score: 1.7103613, Bioorganic & Medicinal Chemistry, 2004, Gérard, Stéphane et. al.
Lipophilic antifolate trimetrexate is a potent inhibitor of Trypanosoma cruzi: prospect for chemotherapy of Chagas' disease.
score: 1.7100251, Antimicrobial agents and chemotherapy, 2005, Senkovich, Olga et. al.
A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease
score: 1.7099823, Bioorganic & Medicinal Chemistry, 2003, Toda, Narihiro et. al.
Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells
score: 1.7099471, Bioorganic & Medicinal Chemistry, 2012, Leal, Ana S.; Wang, Rui; Salvador, Jorge A.R.; Jing, Yongkui
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase
score: 1.7098307, Bioorganic & Medicinal Chemistry, 2012, Linsky, Thomas W.; Fast, Walter
Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives
score: 1.7097812, European Journal of Medicinal Chemistry, 2012, Wang, Peng et. al.
Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential
score: 1.7096306, Bioorganic & Medicinal Chemistry, 2006, Yasuhara, Akito et. al.
Aminothienopyridazine Inhibitors of Tau Aggregation: Evaluation of Structure-Activity Relationship Leads to Selection of Candidates with Desirable In Vivo Properties
score: 1.7096039, Bioorganic & Medicinal Chemistry, 2012, Ballatore, Carlo et. al.
Nonactin biosynthesis: Setting limits on what can be achieved with precursor-directed biosynthesis
score: 1.7094983, Bioorganic & Medicinal Chemistry Letters, 2009, Kusche, Brian R.; Phillips, Joshua B.; Priestley, Nigel D.
Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF.
score: 1.7091766, Antimicrobial agents and chemotherapy, 2006, Baum, Ellen Z et. al.
Synthesis, antimycobacterial and antitumor activities of new (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3 H)-yl)methyl N, N-disubstituted dithiocarbamate/ O-alkyldithiocarbonate derivatives
score: 1.7090845, Bioorganic & Medicinal Chemistry, 2006, Güzel, Özlen; Salman, Aydın
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship
score: 1.7090446, Bioorganic & Medicinal Chemistry, 2004, Murias, Marek et. al.
Synthesis and cytotoxicity of novel isomeric C-seco limonoids
score: 1.7089984, European Journal of Medicinal Chemistry, 2006, Genupur, Anitha et. al.
Structure–activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification
score: 1.7088875, Bioorganic & Medicinal Chemistry Letters, 2012, Sun, Xicheng et. al.
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity
score: 1.7084879, Bioorganic & Medicinal Chemistry, 2005, Bacherikov, Valeriy A. et. al.
Enantioselective synthesis of A 3′-dephenylcryptophycin synthon
score: 1.7083128, Bioorganic & Medicinal Chemistry Letters, 1998, Eggen, MariJean; Georg, Gunda I.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 1.708308, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 1.708308, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Tetrahydro-naphthols as orally available TRPV1 inhibitors
score: 1.708308, Bioorganic & Medicinal Chemistry Letters, 2012, Urbahns, Klaus et. al.
Novel potent metallocenes against liver stage malaria.
score: 1.7083072, Antimicrobial agents and chemotherapy, 2012, Matos, Joana et. al.
Footprint-based identification of viral entry inhibitors targeting HIVgp41
score: 1.7079302, Bioorganic & Medicinal Chemistry Letters, 2012, Holden, Patrick M. et. al.
Potent and orally active ET A selective antagonists with 5,7-diarylcyclopenteno[1,2- b]pyridine-6-carboxylic acid structures
score: 1.7078744, Bioorganic & Medicinal Chemistry, 2004, Yoshizumi, Takashi et. al.
An Hsp90 modulator that exhibits a unique mechanistic profile
score: 1.7076713, Bioorganic & Medicinal Chemistry Letters, 2012, Ramsey, Deborah M. et. al.
An Hsp90 modulator that exhibits a unique mechanistic profile
score: 1.7076713, Bioorganic & Medicinal Chemistry Letters, 2012, Ramsey, Deborah M. et. al.
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family
score: 1.7074929, Bioorganic & Medicinal Chemistry Letters, 2012, Finlay, M. Raymond V.; Griffin, Roger J.
Synthesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives
score: 1.707435, Bioorganic & Medicinal Chemistry, 2006, Foroumadi, Alireza et. al.
Novel macrocyclic and acyclic cationic lipids for gene transfer: Synthesis and in vitro evaluation
score: 1.7073915, Bioorganic & Medicinal Chemistry Letters, 2012, Goldring, William P.D. et. al.
Novel macrocyclic and acyclic cationic lipids for gene transfer: Synthesis and in vitro evaluation
score: 1.7073915, Bioorganic & Medicinal Chemistry Letters, 2012, Goldring, William P.D. et. al.
Glycopeptide mimics of mammalian Man 9GlcNAc 2. Ligand binding to mannan-binding proteins (MBPs)
score: 1.7070498, Bioorganic & Medicinal Chemistry, 1996, Franzyk, Henrik et. al.
Is a Nitrogen Atom an Important Pharmacophoric Element in Sigma Ligand Binding?
score: 1.7070103, Bioorganic & Medicinal Chemistry, 2000, Ablordeppey, Seth Y; Fischer, James B; Glennon, Richard A
Synthesis, structure–activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives
score: 1.706944, European Journal of Medicinal Chemistry, 2012, Liu, Yan-Xin et. al.
Mechanism and structure–activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase
score: 1.7068512, Bioorganic & Medicinal Chemistry, 2005, Dixon, Mark J. et. al.
Discovery of ITX 4520: A highly potent orally bioavailable hepatitis C virus entry inhibitor
score: 1.7068139, Bioorganic & Medicinal Chemistry Letters, 2012, Mittapalli, Gopi Kumar et. al.
Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin.
score: 1.7067572, Antimicrobial agents and chemotherapy, 2012, Shahinas, Dea et. al.
Synthesis and binding mode of heterocyclic analogues of suramin inhibiting the human basic fibroblast growth factor
score: 1.7067456, Bioorganic & Medicinal Chemistry, 1998, Manetti, Fabrizio et. al.
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective Protein Tyrosine Phosphatase 1B inhibitors
score: 1.7067252, Bioorganic & Medicinal Chemistry Letters, 2012, Cheung, Adrian Wai-Hing et. al.
Synthesis and biological evaluation of novel N-acyl substituted quinolin-2(1H)-one derivatives as potential antimicrobial agents
score: 1.7067157, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Hong-Bin et. al.
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
score: 1.7066225, European Journal of Medicinal Chemistry, 2012, Bertinaria, Massimo et. al.
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
score: 1.7066225, European Journal of Medicinal Chemistry, 2012, Bertinaria, Massimo et. al.
8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A 2B
score: 1.7066101, European Journal of Medicinal Chemistry, 2004, Carotti, Angelo et. al.
Synthesis of new chemical entities from paracetamol and NSAIDs with improved pharmacodynamic profile
score: 1.7065724, Bioorganic & Medicinal Chemistry, 2006, Yadav, Mange Ram et. al.
Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies
score: 1.7063621, Bioorganic & Medicinal Chemistry Letters, 2010, Roucairol, Camille et. al.
Stable extended human immunodeficiency virus type 1 gp41 coiled coil as an effective target in an assay for high-affinity fusion inhibitors.
score: 1.7063512, Antimicrobial agents and chemotherapy, 2009, Cai, Lifeng; Balogh, Edina; Gochin, Miriam
Activity predictions for efavirenz analogues with the K103N mutant of HIV reverse transcriptase
score: 1.7063447, Bioorganic & Medicinal Chemistry Letters, 2003, Udier-Blagović, Marina et. al.
Comparative molecular field analysis of selective A 3 adenosine receptor agonists
score: 1.7063018, Bioorganic & Medicinal Chemistry, 1995, Siddiqi, Suhaib M. et. al.
Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state
score: 1.706284, Bioorganic & Medicinal Chemistry, 2012, Wielgus-Kutrowska, Beata et. al.
Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state
score: 1.706284, Bioorganic & Medicinal Chemistry, 2012, Wielgus-Kutrowska, Beata et. al.
Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state
score: 1.706284, Bioorganic & Medicinal Chemistry, 2012, Wielgus-Kutrowska, Beata et. al.
Novel and expanded jadomycins incorporating non-proteogenic amino acids
score: 1.7061556, Bioorganic & Medicinal Chemistry Letters, 2005, Jakeman, David L.; Graham, Cathy L.; Reid, Taryn R.
Nitrofurylsemicarbazone Rhenium and Ruthenium Complexes as Anti-trypanosomal Agents
score: 1.7059005, European Journal of Medicinal Chemistry, 2006, Otero, Lucía et. al.
Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C
score: 1.7057362, Bioorganic & Medicinal Chemistry, 2012, Zervosen, Astrid et. al.
Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C
score: 1.7057362, Bioorganic & Medicinal Chemistry, 2012, Zervosen, Astrid et. al.
3D-QSAR studies on tripeptide aldehyde inhibitors of proteasome using CoMFA and CoMSIA methods
score: 1.7054744, Bioorganic & Medicinal Chemistry, 2006, Zhu, Yong-Qiang et. al.
Design, Synthesis, and Biological Evaluation of Chalcone Oxime Derivatives as Potential Immunosuppressive Agents
score: 1.705248, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Yin et. al.
Novel 5-substituted, 2,4-diaminofuro[2,3- d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity
score: 1.7050775, Bioorganic & Medicinal Chemistry, 2005, Gangjee, Aleem et. al.
Building a successful structural motif into sialylmimetics—cyclohexenephosphonate monoesters as pseudo-sialosides with promising inhibitory properties
score: 1.7050748, Bioorganic & Medicinal Chemistry, 2006, Streicher, Hansjörg; Busse, Heike
Synthesis and properties of cationic 2′-O-[N-(4-aminobutyl)carbamoyl] modified oligonucleotides
score: 1.7046565, Bioorganic & Medicinal Chemistry Letters, 2012, Seio, Kohji et. al.
An improved synthesis of arsenic–biotin conjugates
score: 1.7046016, Bioorganic & Medicinal Chemistry, 2008, Heredia-Moya, Jorge; Kirk, Kenneth L.
Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives
score: 1.7042641, Bioorganic & Medicinal Chemistry, 2003, Cuellar, Mauricio A. et. al.
Synthesis and biological evaluation of orally active matrix metalloproteinase inhibitors
score: 1.7041701, Bioorganic & Medicinal Chemistry, 1997, Hirayama, Ryoichi et. al.
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720
score: 1.7041246, Bioorganic & Medicinal Chemistry, 2004, Hale, Jeffrey J. et. al.
Heteropoly acids as solid green Brønsted acids for a one-pot synthesis of β-acetamido ketones by Dakin–West reaction
score: 1.7041097, Bioorganic & Medicinal Chemistry Letters, 2006, Rafiee, Ezzat; Tork, Fariba; Joshaghani, M.
Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines
score: 1.7041095, European Journal of Medicinal Chemistry, 2005, Katiyar, D. et. al.
Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells
score: 1.7037987, Bioorganic & Medicinal Chemistry Letters, 2012, Khan, Mohammad Faheem et. al.
Studies on the chemistry of thienoanellated O, N- and S, N-containing heterocycles. Part 30: Synthesis and pharmacological properties of thieno[2,3- b][1,4]thiazines with potential vasopressin receptor antagonistic activity
score: 1.7036258, Bioorganic & Medicinal Chemistry, 2006, Galanski, Maria E. et. al.
Molecular modeling and 3D-QSAR studies of indolomorphinan derivatives as kappa opioid antagonists
score: 1.7034625, Bioorganic & Medicinal Chemistry, 2006, Li, Wei; Tang, Yun; Zheng, You-Li; Qiu, Zhui-Bai
Anti-viral activity of (-)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.7031281, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy
score: 1.7029246, Bioorganic & Medicinal Chemistry Letters, 2012, Adams, Mark E. et. al.
Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata
score: 1.7028752, Bioorganic & Medicinal Chemistry, 2006, Cheenpracha, Sarot et. al.
Design, synthesis and biological evaluation of novel riccardiphenol analogs
score: 1.7028196, Bioorganic & Medicinal Chemistry, 2005, Kumar, Srinivas K. et. al.
Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor
score: 1.7027768, Bioorganic & Medicinal Chemistry Letters, 2013, Giordanetto, Fabrizio et. al.
Synthesis, characterization and biological evaluation of novel 6-ferrocenyl-4-aryl-2-substituted pyrimidine derivatives
score: 1.7027217, European Journal of Medicinal Chemistry, 2010, Parveen, Humaira et. al.
Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro
score: 1.7025678, Bioorganic & Medicinal Chemistry, 1997, Posner, Gary H. et. al.
Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.
score: 1.7023794, Antimicrobial agents and chemotherapy, 2011, Carroll, Steven S et. al.
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1
score: 1.7023362, Bioorganic & Medicinal Chemistry Letters, 2012, Manjulatha, Khanapur et. al.
Synthesis of cembranoid analogues and evaluation of their potential as quorum sensing inhibitors
score: 1.7019389, Bioorganic & Medicinal Chemistry, 2013, Tello, Edisson; Castellanos, Leonardo; Duque, Carmenza
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors
score: 1.7019297, Bioorganic & Medicinal Chemistry, 2005, Rawal, Ravindra K. et. al.
Synthesis and glycosidase inhibitory activity of some N-substituted 5a-carba-β-fuco- and β-galactopyranosylamines, and selected derivatives
score: 1.7017982, Bioorganic & Medicinal Chemistry, 2004, Ogawa, Seiichiro et. al.
Purpuroines A–J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases
score: 1.701699, Bioorganic & Medicinal Chemistry, 2012, Shen, Shi; Liu, Dong; Wei, Chen; Proksch, Peter; Lin, Wenhan
Purpuroines A–J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases
score: 1.701699, Bioorganic & Medicinal Chemistry, 2012, Shen, Shi; Liu, Dong; Wei, Chen; Proksch, Peter; Lin, Wenhan
Purpuroines A–J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases
score: 1.701699, Bioorganic & Medicinal Chemistry, 2012, Shen, Shi; Liu, Dong; Wei, Chen; Proksch, Peter; Lin, Wenhan
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach
score: 1.7016054, European Journal of Medicinal Chemistry, 2013, Zhang, Zhichao et. al.
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach
score: 1.7016054, European Journal of Medicinal Chemistry, 2013, Zhang, Zhichao et. al.
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol
score: 1.7014999, Bioorganic & Medicinal Chemistry, 2012, Cho, Suengmok et. al.
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol
score: 1.7014999, Bioorganic & Medicinal Chemistry, 2012, Cho, Suengmok et. al.
Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux
score: 1.7012783, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Melvin J.; Zheng, Wanjun; Tendyke, Karen
Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux
score: 1.7012783, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Melvin J.; Zheng, Wanjun; Tendyke, Karen
Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux
score: 1.7012783, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Melvin J.; Zheng, Wanjun; Tendyke, Karen
Appraisal of GABA and PABA as linker: Design and synthesis of novel benzamide based histone deacetylase inhibitors
score: 1.7012515, European Journal of Medicinal Chemistry, 2012, Rajak, Harish et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.701078, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.701078, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
score: 1.701078, Bioorganic & Medicinal Chemistry Letters, 2012, Khodade, Vinayak S. et. al.
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091
score: 1.7009948, Bioorganic & Medicinal Chemistry Letters, 2012, Uchiro, Hiromi et. al.
Camptothecin: current perspectives
score: 1.7008673, Bioorganic & Medicinal Chemistry, 2004, Thomas, Craig J.; Rahier, Nicolas J.; Hecht, Sidney M.
Chemoenzymatic synthesis and biological evaluation of C-3 carbamate analogues of 1α,25-dihydroxyvitamin D 3
score: 1.700608, Bioorganic & Medicinal Chemistry, 2004, Gotor-Fernández, Vicente et. al.
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors
score: 1.7002373, Bioorganic & Medicinal Chemistry Letters, 2013, Ye, Xiaocong M. et. al.
Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole
score: 1.7002352, Bioorganic & Medicinal Chemistry Letters, 2010, Todoroki, Yasushi et. al.
Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
score: 1.7002069, European Journal of Medicinal Chemistry, 2012, Sumangala, V. et. al.
Novel non-steroidal/non-anilide type androgen antagonists: discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands
score: 1.700157, Bioorganic & Medicinal Chemistry, 2005, Wakabayashi, Ken-ichi et. al.
2-Alkynyl-8-aryladenines possessing an amide moiety: their synthesis and structure–activity relationships of effects on hepatic glucose production induced via agonism of the A 2B adenosine receptor
score: 1.6996252, Bioorganic & Medicinal Chemistry, 2001, Harada, Hitoshi et. al.
Synthesis and conformational analysis of peptide inhibitors of farnesyltransferase
score: 1.6995529, Bioorganic & Medicinal Chemistry, 1997, Byk, Gerardo et. al.
Synthesis, DNA binding and cleavage activity of macrocyclic polyamines bearing mono- or bis-acridine moieties
score: 1.6995109, European Journal of Medicinal Chemistry, 2010, Liu, Qiang et. al.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
score: 1.6994593, Bioorganic & Medicinal Chemistry, 2012, Nishida, Haruyuki et. al.
A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure–activity relationships (2)
score: 1.6994421, Bioorganic & Medicinal Chemistry, 2006, Nomura, Takashi et. al.
Synthesis of a novel prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2- trans-propenoic acid for colon delivery
score: 1.6993634, Bioorganic & Medicinal Chemistry Letters, 2005, Curini, Massimo; Epifano, Francesco; Genovese, Salvatore
Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties
score: 1.6992798, Bioorganic & Medicinal Chemistry Letters, 2012, Chang, Dong-Jo et. al.
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.
score: 1.6991021, Antimicrobial agents and chemotherapy, 1999, Patick, A K et. al.
Synthesis, and In vitro and In vivo muscarinic pharmacological properties of a series of 1,6-Dihydro-5-(4 H)-pyrimidinone oximes
score: 1.6990796, Bioorganic & Medicinal Chemistry, 1998, Plate, Ralf et. al.
Synthesis, structure−activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives
score: 1.6989321, European Journal of Medicinal Chemistry, 2012, Liu, Yan−Xin et. al.
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
score: 1.6988956, Bioorganic & Medicinal Chemistry Letters, 2012, Foot, Jonathan S. et. al.
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
score: 1.6988956, Bioorganic & Medicinal Chemistry Letters, 2012, Foot, Jonathan S. et. al.
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
score: 1.6988956, Bioorganic & Medicinal Chemistry Letters, 2012, Foot, Jonathan S. et. al.
Conformationally Restricted Hybrid Analogues of the Hormone 1α,25-Dihydroxyvitamin D 3: Design, Synthesis, and Biological Evaluation
score: 1.6985604, Bioorganic & Medicinal Chemistry, 2001, White, M.Christina et. al.
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
score: 1.6985074, Antimicrobial agents and chemotherapy, 2008, Cihlar, Tomas et. al.
Synthesis and structure–activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents
score: 1.6984587, Bioorganic & Medicinal Chemistry, 2005, Albrecht, Uwe et. al.
Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activity
score: 1.698243, Bioorganic & Medicinal Chemistry Letters, 2012, Min, Byung Sun et. al.
On the use of volume maps in the conformational analysis of vitamin D analogs
score: 1.6981749, Bioorganic & Medicinal Chemistry Letters, 1998, Van Haver, D.; De Clercq, P.J.
3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents
score: 1.6980607, Bioorganic & Medicinal Chemistry, 2002, Hellberg, Mark R. et. al.
Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: New selective ligands for the cannabinoid CB 2 receptor
score: 1.69775, Bioorganic & Medicinal Chemistry, 2006, Marriott, Karla-Sue C. et. al.
Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H 3-antagonists
score: 1.6977483, Bioorganic & Medicinal Chemistry, 2004, Mor, Marco et. al.
A novel and facile preparation of bremazocine enantiomers through optically pure N-norbremazocines
score: 1.6976935, Bioorganic & Medicinal Chemistry, 2004, Greiner, Elisabeth et. al.
Competitive antagonism of insect GABA receptors by iminopyridazine derivatives of GABA
score: 1.6975585, Bioorganic & Medicinal Chemistry, 2012, Rahman, Mohammad Mostafizur et. al.
Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
score: 1.6973265, Antimicrobial agents and chemotherapy, 2012, Zhu, Xiaohua et. al.
Cluster analysis and two-dimensional quantitative structure–activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors
score: 1.6969698, Bioorganic & Medicinal Chemistry Letters, 2006, Kadam, Rameshwar U.; Roy, Nilanjan
Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.
score: 1.6969419, Antimicrobial agents and chemotherapy, 1998, Turpin, J A et. al.
An improved synthesis of 1,2,4-oxadiazoles on solid support
score: 1.6969393, Bioorganic & Medicinal Chemistry Letters, 2001, Rice, Kenneth D.; Nuss, John M.
Novel postentry inhibitor of human immunodeficiency virus type 1 replication screened by yeast membrane-associated two-hybrid system.
score: 1.6967083, Antimicrobial agents and chemotherapy, 2011, Urano, Emiko et. al.
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s Disease
score: 1.6965565, Bioorganic & Medicinal Chemistry Letters, 2012, Al-Baghdadi, Osamah et. al.
Synthesis of novel long wavelength cationic chlorins via stereoselective aldol-like condensation
score: 1.6964322, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Jia Zhu et. al.
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors
score: 1.6963986, European Journal of Medicinal Chemistry, 2012, Iranshahi, Mehrdad et. al.
Practical, asymmetric synthesis of 16-hydroxyeicosa-5( Z),8( Z), 11( Z),14( Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity
score: 1.6963803, Bioorganic & Medicinal Chemistry Letters, 2003, Reddy, Y.Krishna et. al.
Search for α-glucosidase inhibitors: New N-substituted valienamine and conduramine F-1 derivatives
score: 1.6963391, Bioorganic & Medicinal Chemistry, 2006, Łysek, Robert et. al.
Ester derivatives of annulated tetrahydroazocines: A new class of selective acetylcholinesterase inhibitors
score: 1.6963012, Bioorganic & Medicinal Chemistry, 2006, Carotti, Andrea et. al.
Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation
score: 1.6962361, Bioorganic & Medicinal Chemistry, 2006, Ganesh, Thota et. al.
Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolyl N-Acylhydrazone Derivatives
score: 1.6960481, Bioorganic & Medicinal Chemistry, 2000, Figueiredo, Juliana M et. al.
Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines
score: 1.69592, Bioorganic & Medicinal Chemistry Letters, 2013, Vandekerckhove, Stéphanie et. al.
ortho-Carbaborane Derivatives of Indomethacin as Cyclooxygenase (COX)-2 Selective Inhibitors
score: 1.6958775, Bioorganic & Medicinal Chemistry, 2012, Scholz, Matthias et. al.
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials
score: 1.695713, European Journal of Medicinal Chemistry, 2012, Pérez, Bianca C. et. al.
Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines
score: 1.6956866, Bioorganic & Medicinal Chemistry, 2006, Mahaney, Paige E. et. al.
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties
score: 1.6954121, Bioorganic & Medicinal Chemistry Letters, 2012, Shi, Dayong et. al.
Potent antibacterial lysine–peptoid hybrids identified from a positional scanning combinatorial library
score: 1.6953497, Bioorganic & Medicinal Chemistry, 2006, Ryge, Trine S.; Hansen, Paul R.
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
score: 1.6953171, European Journal of Medicinal Chemistry, 2012, Marhadour, Sophie et. al.
Synthesis and SAR exploration of dinapsoline analogues
score: 1.6950921, Bioorganic & Medicinal Chemistry, 2004, Sit, Sing-Yuen et. al.
Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid.
score: 1.6949436, Antimicrobial agents and chemotherapy, 1999, Woo, A J; Strohl, W R; Priestley, N D
Synthesis and Structure–Activity Relationship of Diarylamide Derivatives as Selective Inhibitors of the Proliferation of Human Endothelial Cells
score: 1.6949421, Bioorganic & Medicinal Chemistry, 2002, Ogita, Haruhisa et. al.
Phthalazine PDE IV inhibitors: Conformational study of some 6-methoxy-1,4-disubstituted derivatives
score: 1.6948004, Bioorganic & Medicinal Chemistry, 2005, Haack, Thomas et. al.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor
score: 1.6944159, Bioorganic & Medicinal Chemistry Letters, 2012, Maloney, Patrick R. et. al.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor
score: 1.6944159, Bioorganic & Medicinal Chemistry Letters, 2012, Maloney, Patrick R. et. al.
The flexibility of the Le aLe x Tumor Associated Antigen central fragment studied by systematic and stochastic searches as well as dynamic simulations
score: 1.6941882, Bioorganic & Medicinal Chemistry, 2009, Jackson, Trudy A. et. al.
Unprecedented spirocyclization of 3-methyleneindoline-2-thiones during hydrolysis of the phytoalexin cyclobrassinin
score: 1.694163, Bioorganic & Medicinal Chemistry Letters, 2013, Pedras, M. Soledade C. et. al.
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
score: 1.6940573, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xiao Yun et. al.
Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups
score: 1.6939509, Bioorganic & Medicinal Chemistry, 2012, Tu, Zhude et. al.
Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn 2+ in aqueous solution
score: 1.6938065, Bioorganic & Medicinal Chemistry Letters, 2007, Joshi, Bishnu Prasad et. al.
Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
score: 1.6933809, Bioorganic & Medicinal Chemistry, 2012, Mokale, Santosh N.; Lokwani, Deepak; Shinde, Devanand B.
Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
score: 1.6933809, Bioorganic & Medicinal Chemistry, 2012, Mokale, Santosh N.; Lokwani, Deepak; Shinde, Devanand B.
Discovery and modification of Sulfur-containing Heterocyclic Pyrazoline Derivatives as Potential novel class of β-Ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.6932814, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Yu-Shun et. al.
Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
score: 1.6932718, European Journal of Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
score: 1.6932718, European Journal of Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
score: 1.6932718, European Journal of Medicinal Chemistry, 2012, Bandgar, Babasaheb P. et. al.
Structure–activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors
score: 1.6931903, Bioorganic & Medicinal Chemistry, 2005, Wan, Sheng Biao et. al.
Effect of 4-substitution on psychotomimetic activity of 2,5-dimethoxy amphetamines as studied by means of different substituent parameter scales
score: 1.6931877, Bioorganic & Medicinal Chemistry Letters, 2006, Neuvonen, Kari; Neuvonen, Helmi; Fülöp, Ferenc
Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine
score: 1.6930883, Bioorganic & Medicinal Chemistry Letters, 2012, Clouser, Christine L. et. al.
Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine
score: 1.6930883, Bioorganic & Medicinal Chemistry Letters, 2012, Clouser, Christine L. et. al.
Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents
score: 1.6930279, Bioorganic & Medicinal Chemistry, 2006, Balbi, Alessandro et. al.
In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.
score: 1.6929564, Antimicrobial agents and chemotherapy, 2004, Urbina, Julio A et. al.
Anti-viral activity of (−)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.6928771, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Anti-viral activity of (−)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.6928771, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Anti-viral activity of (−)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009
score: 1.6928771, Bioorganic & Medicinal Chemistry Letters, 2012, Sokolov, Dmitriy N. et. al.
Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives
score: 1.6928077, Bioorganic & Medicinal Chemistry, 2005, Bacherikov, Valeriy A. et. al.
QSAR of HIV-1 integrase inhibitors by genetic function approximation method
score: 1.6927517, Bioorganic & Medicinal Chemistry, 2002, Makhija, Mahindra T.; Kulkarni, Vithal M.
A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs
score: 1.6926341, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang
Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studies
score: 1.6926133, Bioorganic & Medicinal Chemistry, 2005, Lambert, Joshua D. et. al.
N-(5-substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase
score: 1.6923177, Bioorganic & Medicinal Chemistry, 1997, Beers, Scott A. et. al.
Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles
score: 1.6919601, Bioorganic & Medicinal Chemistry, 2005, Göker, Hakan; Boykin, David W.; Yıldız, Sulhiye
Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
score: 1.6918063, Bioorganic & Medicinal Chemistry Letters, 2012, Ágai-Csongor, Éva et. al.
Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
score: 1.6918063, Bioorganic & Medicinal Chemistry Letters, 2012, Ágai-Csongor, Éva et. al.
Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
score: 1.6918063, Bioorganic & Medicinal Chemistry Letters, 2012, Ágai-Csongor, Éva et. al.
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents
score: 1.6918056, European Journal of Medicinal Chemistry, 2012, Pierce, Larry T. et. al.
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents
score: 1.6918056, European Journal of Medicinal Chemistry, 2012, Pierce, Larry T. et. al.
Synthesis and antibacterial activity of some new 1-heteroaryl-5-amino-3 H/methyl-4-phenylpyrazoles
score: 1.6915466, Bioorganic & Medicinal Chemistry, 2006, Aggarwal, Ranjana et. al.
A graftable LDV peptidomimetic: Design, synthesis and application to a blood filtration membrane
score: 1.6914979, Bioorganic & Medicinal Chemistry Letters, 2008, Momtaz, Maryam et. al.
Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives
score: 1.6909442, European Journal of Medicinal Chemistry, 2012, Raimondi, Maria Valeria et. al.
Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives
score: 1.6909442, European Journal of Medicinal Chemistry, 2012, Raimondi, Maria Valeria et. al.
Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition
score: 1.6909413, Bioorganic & Medicinal Chemistry Letters, 2009, Ai, Chunzhi et. al.
Action mechanisms and structure–activity relationships of PI3Kγ inhibitors on the enzyme: a molecular modeling study
score: 1.6908921, European Journal of Medicinal Chemistry, 2006, Kuang, R.-R.; Qian, F.; Li, Z.; Wei, D.-Z.; Tang, Y.
Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents
score: 1.6907758, European Journal of Medicinal Chemistry, 2004, Mayence, Annie et. al.
In vitro antimycobacterial activities of 2'-monosubstituted isonicotinohydrazides and their cyanoborane adducts.
score: 1.6907652, Antimicrobial agents and chemotherapy, 2002, Maccari, Rosanna et. al.
Arylsulfonyl acridinyl derivatives acting on Plasmodium falciparum
score: 1.6907528, European Journal of Medicinal Chemistry, 2004, Santelli-Rouvier, Christiane et. al.
1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl Esters, a Novel Compound Class with Potent Chemoreversal Activity
score: 1.6906068, Bioorganic & Medicinal Chemistry Letters, 2012, Hung, Hsin-Yi et. al.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
score: 1.6905414, Bioorganic & Medicinal Chemistry, 2012, Nishida, Haruyuki et. al.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
score: 1.6905414, Bioorganic & Medicinal Chemistry, 2012, Nishida, Haruyuki et. al.
Binding affinity prediction of non-peptide inhibitors of HIV-1 protease using COMBINE model introduced from peptide inhibitors
score: 1.6904883, Bioorganic & Medicinal Chemistry Letters, 2006, Nakamura, Shinya; Nakanishi, Isao; Kitaura, Kazuo
Selenium-containing naphthalimides as anticancer agents: Design, synthesis and bioactivity
score: 1.6900569, Bioorganic & Medicinal Chemistry, 2012, Zhao, Liwei et. al.
Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
score: 1.6896645, Bioorganic & Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
score: 1.6896645, Bioorganic & Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
score: 1.6896645, Bioorganic & Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Synthetic study of phosphopeptides related to heat shock protein HSP27
score: 1.6894251, Bioorganic & Medicinal Chemistry, 1997, Wakamiya, Tateaki et. al.
Oxoquinoline acyclonucleoside phosphonate analogues as a new class of specific inhibitors of human immunodeficiency virus type 1
score: 1.6892866, Bioorganic & Medicinal Chemistry Letters, 2012, Faro, Letícia V. et. al.
Azabicyclic indole esters as potent 5-HT 4 receptor antagonists
score: 1.6889188, Bioorganic & Medicinal Chemistry, 1996, Wyman, Paul A. et. al.
Synthesis and structure–activity relationships of a new class of selective EP 3 receptor agonist, 13,14-didehydro-16-phenoxy analogues of prostaglandin E 1
score: 1.6888481, Bioorganic & Medicinal Chemistry, 2000, Shimazaki, Youichi et. al.
Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea
score: 1.6888295, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, You Ah et. al.
Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea
score: 1.6888295, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, You Ah et. al.
Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea
score: 1.6888295, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, You Ah et. al.
Synthesis and structure-activity relationships of dual histamine H 2 and gastrin receptor antagonists with decreased hydrophobicity
score: 1.6887393, Bioorganic & Medicinal Chemistry, 1997, Kawanishi, Yasuyuki et. al.
Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: Potential PET imaging agents for tumor detection
score: 1.6886852, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yurong et. al.
Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: Potential PET imaging agents for tumor detection
score: 1.6886852, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yurong et. al.
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B
score: 1.6885458, Bioorganic & Medicinal Chemistry Letters, 2012, Lewellyn, Kevin et. al.
Design of environmentally sensitive fluorescent 2′-deoxyguanosine containing arylethynyl moieties: Distinction of thymine base by base-discriminating fluorescent (BDF) probe
score: 1.6884712, Bioorganic & Medicinal Chemistry Letters, 2010, Shinohara, Yuta et. al.
Ring-substituted quinolines as potential anti-tuberculosis agents
score: 1.6883548, Bioorganic & Medicinal Chemistry, 2004, Vangapandu, Suryanarayana et. al.
Synthesis and cytotoxic activity of substituted 7-aryliminomethyl derivatives of camptothecin
score: 1.6882534, European Journal of Medicinal Chemistry, 2004, Dallavalle, Sabrina et. al.
Synthesis and SAR studies of a novel series of T-type calcium channel blockers
score: 1.6881264, Bioorganic & Medicinal Chemistry, 2006, Park, Seong Jun et. al.
Synthesis and dual biological effects of hydroxycinnamoyl phenylalanyl/prolyl hydroxamic acid derivatives as tyrosinase inhibitor and antioxidant
score: 1.6878806, Bioorganic & Medicinal Chemistry Letters, 2013, Kwak, Seon-Yeong et. al.
Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors
score: 1.6878203, Bioorganic & Medicinal Chemistry, 2012, Liu, Yang et. al.
Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 1
score: 1.687713, Bioorganic & Medicinal Chemistry Letters, 2012, Delouvrié, Bénédicte et. al.
Orally Active Cephalosporins. Part 4: Synthesis, Structure–Activity Relationships and Oral Absorption of Novel 3-(4-Pyrazolylmethylthio)cephalosporins with Various C-7 Side Chains
score: 1.6874007, Bioorganic & Medicinal Chemistry, 2002, Yamamoto, Hirofumi et. al.
Biomolecular assembly by iterative oxime ligations
score: 1.6873351, Bioorganic & Medicinal Chemistry Letters, 2009, Renaudet, Olivier; Boturyn, Didier; Dumy, Pascal
Sulfonamide bearing oligonucleotides: Simple synthesis and efficient RNA recognition
score: 1.687217, Bioorganic & Medicinal Chemistry, 2012, Kumar, Pawan et. al.
Sulfonamide bearing oligonucleotides: Simple synthesis and efficient RNA recognition
score: 1.687217, Bioorganic & Medicinal Chemistry, 2012, Kumar, Pawan et. al.
Sulfonamide bearing oligonucleotides: Simple synthesis and efficient RNA recognition
score: 1.687217, Bioorganic & Medicinal Chemistry, 2012, Kumar, Pawan et. al.
Synthesis, structure–activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives
score: 1.6870634, European Journal of Medicinal Chemistry, 2012, Liu, Yan-Xin et. al.
Synthesis, structure–activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives
score: 1.6870634, European Journal of Medicinal Chemistry, 2012, Liu, Yan-Xin et. al.
Chemotherapy of leishmaniasis part X: Synthesis and bioevaluation of novel terpenyl heterocycles
score: 1.6869298, Bioorganic & Medicinal Chemistry Letters, 2013, Tiwari, Avinash et. al.
Ligand-based assessment of factor Xa binding site flexibility via elaborate pharmacophore exploration and genetic algorithm-based QSAR modeling
score: 1.6868732, European Journal of Medicinal Chemistry, 2005, Taha, Mutasem O. et. al.
In silico ADME modelling 2: Computational models to predict human serum albumin binding affinity using ant colony systems
score: 1.686501, Bioorganic & Medicinal Chemistry, 2006, Gunturi, Sitarama B. et. al.
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I
score: 1.6864969, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I
score: 1.6864969, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I
score: 1.6864969, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
1-Alkoxycarbonyl-3-halogenoazetidin-2-ones as elastase (PPE) inhibitors
score: 1.6864633, Bioorganic & Medicinal Chemistry, 2002, Gérard, Stéphane et. al.
Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea
score: 1.6862557, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, You Ah et. al.
Synthesis and activity of 5′-Uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A
score: 1.6859381, Bioorganic & Medicinal Chemistry, 2003, Howard, Nigel I; Bugg, Timothy D.H
Identification of the first fluorescent α-amidoboronic acids that change fluorescent properties upon sugar binding
score: 1.6858616, Bioorganic & Medicinal Chemistry Letters, 2009, Jin, Shan; Zhu, Chunyuan; Li, Minyong; Wang, Binghe
Optically active cantharidin analogues possessing selective inhibitory activity on Ser/Thr protein phosphatase 2B (calcineurin): Implications for the binding mode
score: 1.685757, Bioorganic & Medicinal Chemistry, 2005, Baba, Yoshiyasu; Hirukawa, Nozomu; Sodeoka, Mikiko
3-hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1.
score: 1.6856921, Antimicrobial agents and chemotherapy, 2010, Li, Lin et. al.
Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen.
score: 1.6856662, Antimicrobial agents and chemotherapy, 2006, Müh, Ute et. al.
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
score: 1.6856254, European Journal of Medicinal Chemistry, 2012, Maalej, Emna et. al.
Post-docking virtual screening of diverse binding pockets: Comparative study using DOCK, AMMOS, X-Score and FRED scoring functions
score: 1.6853225, European Journal of Medicinal Chemistry, 2010, Pencheva, Tania et. al.
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth
score: 1.6846994, Bioorganic & Medicinal Chemistry Letters, 2012, Siiskonen, Antti et. al.
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth
score: 1.6846994, Bioorganic & Medicinal Chemistry Letters, 2012, Siiskonen, Antti et. al.
Physiochemical drug properties associated with in vivo toxicological outcomes
score: 1.6846347, Bioorganic & Medicinal Chemistry Letters, 2008, Hughes, Jason D. et. al.
Synthesis and characterisation of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity
score: 1.6844794, European Journal of Medicinal Chemistry, 2010, Vrdoljak, Višnja et. al.
J-104129, a novel muscarinic M 3 receptor antagonist with high selectivity for M 3 over M 2 receptors
score: 1.6844607, Bioorganic & Medicinal Chemistry, 1999, Mitsuya, Morihiro et. al.
First QSAR report on FSH receptor antagonistic activity: Quantitative investigations on physico-chemical and structural features among 6-amino-4-phenyltetrahydroquinoline derivatives
score: 1.6844263, Bioorganic & Medicinal Chemistry Letters, 2005, Manivannan, E.; Prasanna, S.
Anti-inflammatory activity and QSAR studies of compounds isolated from Hyacinthaceae species and Tachiadenus longiflorus Griseb. (Gentianaceae)
score: 1.6843877, Bioorganic & Medicinal Chemistry, 2005, du Toit, Karen et. al.
Effect of substituents at phenyl group of 7,7′-dioxo-9,9′-epoxylignane on antifungal activity
score: 1.6843449, Bioorganic & Medicinal Chemistry Letters, 2012, Nishiwaki, Hisashi et. al.
Effect of substituents at phenyl group of 7,7′-dioxo-9,9′-epoxylignane on antifungal activity
score: 1.6843449, Bioorganic & Medicinal Chemistry Letters, 2012, Nishiwaki, Hisashi et. al.
Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli
score: 1.6841266, Bioorganic & Medicinal Chemistry, 2006, Chhibber, Manmohan et. al.
Superimposing the 27 crystal protein/inhibitor complexes of β-secretase to calculate the binding affinities by the linear interaction energy method
score: 1.6840969, Bioorganic & Medicinal Chemistry Letters, 2010, Liu, Shu; Zhou, Li-Hua; Wang, Hua-Qiao; Yao, Zhi-Bin
The effect of different electrostatic potentials on docking accuracy: A case study using DOCK5.4
score: 1.6839772, Bioorganic & Medicinal Chemistry Letters, 2008, Tsai, Keng-Chang et. al.
Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units
score: 1.6839293, Bioorganic & Medicinal Chemistry, 2004, Haginoya, Noriyasu et. al.
Synthesis and antimalarial activity of new haemanthamine-type derivatives
score: 1.6839257, Bioorganic & Medicinal Chemistry, 2012, Cedrón, Juan C. et. al.
Quantitative structure activity relationship studies of diaryl furanones as selective COX-2 inhibitors
score: 1.6838798, European Journal of Medicinal Chemistry, 2004, Shahapurkar, S. et. al.
Quantitative structure activity relationship studies of diaryl furanones as selective COX-2 inhibitors
score: 1.6838798, European Journal of Medicinal Chemistry, 2004, Shahapurkar, S. et. al.
Heteroaryl Urea Inhibitors of Fatty Acid Amide Hydrolase: Structure-Mutagenicity Relationships for Arylamine Metabolites
score: 1.6838454, Bioorganic & Medicinal Chemistry Letters, 2012, Tichenor, Mark S. et. al.
Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.
score: 1.683833, Antimicrobial agents and chemotherapy, 2012, Lamarche, M J et. al.
Modelling, synthesis and biological evaluation of novel glucuronide-based probes of Vibrio cholerae sialidase
score: 1.6837778, Bioorganic & Medicinal Chemistry, 2006, Mann, Maretta C. et. al.
QSAR and molecular modelling studies on B-DNA recognition of minor groove binders
score: 1.6837089, European Journal of Medicinal Chemistry, 2003, Oliveira, André Mauricio de et. al.
Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode
score: 1.6836446, Bioorganic & Medicinal Chemistry, 2012, Shi, Genbin et. al.
Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode
score: 1.6836446, Bioorganic & Medicinal Chemistry, 2012, Shi, Genbin et. al.
Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1- c][1,4]benzodiazepine conjugates
score: 1.6836436, Bioorganic & Medicinal Chemistry, 2005, Kamal, Ahmed; Devaiah, V.; Reddy, K. Laxma; Kumar, M. Shiva
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
score: 1.6832344, European Journal of Medicinal Chemistry, 2012, Li, Xue et. al.
The recent impact of solid-phase synthesis on medicinally relevant benzoannelated nitrogen heterocycles
score: 1.6831039, Bioorganic & Medicinal Chemistry, 2002, Bräse, Stefan; Gil, Carmen; Knepper, Kerstin
Synthesis and Evaluation of [18F]Fluorobutyl Ethacrynic Amide: A Potential PET Tracer for Studying Glutathione Transferase
score: 1.6830429, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Ho-Lien et. al.
Synthesis and NMDA-receptor affinity of 4-oxo-dexoxadrol derivatives
score: 1.6830186, Bioorganic & Medicinal Chemistry, 2006, Sax, Michael et. al.
Comparative molecular field analysis (CoMFA) and docking studies of non-nucleoside HIV-1 RT inhibitors (NNIs)
score: 1.6829224, Bioorganic & Medicinal Chemistry, 1999, Barreca, M.L. et. al.
Synthesis and antiallergic activity of pyridothienopyrimidines
score: 1.6827465, Bioorganic & Medicinal Chemistry, 1998, Quintela, José M. et. al.
Synthesis of pyrrolo[2,1- c][1,4]benzodiazepines via reductive cyclization of ω-azido carbonyl compounds by TMSI: an efficient preparation of antibiotic DC-81 and its dimers
score: 1.6824746, Bioorganic & Medicinal Chemistry Letters, 2000, Kamal, Ahmed; Laxman, E.; Laxman, N.; Venugopal Rao, N.
Synthesis and antimycobacterial activity of some phthalimide derivatives
score: 1.6823673, Bioorganic & Medicinal Chemistry, 2012, Akgün, Hülya et. al.
Synthesis and antimycobacterial activity of some phthalimide derivatives
score: 1.6823673, Bioorganic & Medicinal Chemistry, 2012, Akgün, Hülya et. al.
Synthesis and antimycobacterial activity of some phthalimide derivatives
score: 1.6823673, Bioorganic & Medicinal Chemistry, 2012, Akgün, Hülya et. al.
Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent
score: 1.6823564, Bioorganic & Medicinal Chemistry Letters, 2012, Odan, Masahide et. al.
Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors
score: 1.6822063, Bioorganic & Medicinal Chemistry Letters, 2012, Canales, Eda et. al.
Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors
score: 1.6822063, Bioorganic & Medicinal Chemistry Letters, 2012, Canales, Eda et. al.
Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors
score: 1.6822063, Bioorganic & Medicinal Chemistry Letters, 2012, Canales, Eda et. al.
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors
score: 1.6820431, Bioorganic & Medicinal Chemistry, 2006, Randolph, John T. et. al.
Design, synthesis and binding properties of novel and selective 5-HT 3 and 5-HT 4 receptor ligands
score: 1.6817938, European Journal of Medicinal Chemistry, 2000, Modica, Maria et. al.
QSAR study of quinolinediones with inhibitory activity of endothelium-Dependent vasorelaxation by CoMSIA
score: 1.6817413, Bioorganic & Medicinal Chemistry, 2003, Choo, Hea-Young Park et. al.
Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies
score: 1.681612, Bioorganic & Medicinal Chemistry, 2004, Laco, Gary S. et. al.
Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents
score: 1.6815238, European Journal of Medicinal Chemistry, 2012, Abd El Hamid, Mohammed K. et. al.
Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents
score: 1.6815238, European Journal of Medicinal Chemistry, 2012, Abd El Hamid, Mohammed K. et. al.
Design, synthesis, and biological activity of novel triazole amino acids used to probe binding interactions between ligand and neutral amino acid transport protein SN1
score: 1.6814792, Bioorganic & Medicinal Chemistry Letters, 2007, Gajewski, Mariusz; Seaver, Ben; Esslinger, C. Sean
Polycyclic aromatic compounds as anticancer agents: structure–activity relationships of chrysene and pyrene derivatives
score: 1.6812535, Bioorganic & Medicinal Chemistry, 2001, Banik, Bimal K; Becker, Frederick F
A novel class of endothelin-A receptor antagonists, ( R)-2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-2 H-chromene-3-carboxylic acids (S-1255). Conformational analysis of basic structure, crucial for ET A antagonism, in solution and solid states
score: 1.6810489, Bioorganic & Medicinal Chemistry, 2002, Ishizuka, Natsuki et. al.
Synthesis and SAR of selective small molecule Neuropeptide Y Y2 receptor antagonists
score: 1.6810479, Bioorganic & Medicinal Chemistry Letters, 2012, Mittapalli, Gopi Kumar et. al.
Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity
score: 1.6808827, Bioorganic & Medicinal Chemistry Letters, 2012, Kusano, Shuhei et. al.
Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity
score: 1.6808827, Bioorganic & Medicinal Chemistry Letters, 2012, Kusano, Shuhei et. al.
Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity
score: 1.6808827, Bioorganic & Medicinal Chemistry Letters, 2012, Kusano, Shuhei et. al.
Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors
score: 1.680823, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Shaojing et. al.
Altering the specificity of subtilisin Bacillus lentus through the introduction of positive charge at single amino acid sites
score: 1.6807805, Bioorganic & Medicinal Chemistry, 1999, Davis, Benjamin G. et. al.
The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues
score: 1.6804509, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Weibin et. al.
The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues
score: 1.6804509, Bioorganic & Medicinal Chemistry Letters, 2012, Song, Weibin et. al.
Design, Synthesis and Biological Evaluation of Oxazolidinone–Quinolone Hybrids
score: 1.680377, Bioorganic & Medicinal Chemistry, 2003, Hubschwerlen, Christian et. al.
The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases
score: 1.6800198, Bioorganic & Medicinal Chemistry Letters, 2006, Iley, Jim et. al.
Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40
score: 1.6797396, Bioorganic & Medicinal Chemistry Letters, 2012, Peng, Jixing et. al.
3β-Hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity
score: 1.6796708, Bioorganic & Medicinal Chemistry, 2000, Xie, Wenge et. al.
New chemical and biological aspects of artemisinin-Derived trioxane dimers
score: 1.6795744, Bioorganic & Medicinal Chemistry, 2002, Posner, Gary H et. al.
Discovery of a new chemical lead for a matrix metalloproteinase inhibitor
score: 1.6793635, Bioorganic & Medicinal Chemistry, 2006, Ikura, Masahiro et. al.
A new, efficient, and simple method for the one-pot synthesis of α-acetoxyphosphonates from aldehydes under solvent-free conditions
score: 1.6793554, Bioorganic & Medicinal Chemistry Letters, 2006, Kaboudin, Babak; Karimi, Masoumeh
Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. part 4: Biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries
score: 1.678895, Bioorganic & Medicinal Chemistry, 2003, Ferraris, Dana et. al.
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement
score: 1.6786819, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement
score: 1.6786819, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Small molecule amides as potent ROR-γ selective modulators
score: 1.6784155, Bioorganic & Medicinal Chemistry Letters, 2013, Khan, Pasha M. et. al.
α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors
score: 1.6783651, Bioorganic & Medicinal Chemistry, 2005, Gao, Hong; Kawabata, Jun
Discovery and structure–activity relationship studies of a novel and specific peptide motif, pro-X-X-X-asp-X, as a platelet fibrinogen receptor antagonist
score: 1.6782238, Bioorganic & Medicinal Chemistry, 1998, Hayashi, Yoshio et. al.
Synthesis and herbicidal activities of 2-cyano-3-benzylaminoacrylates containing thiazole moiety
score: 1.6781061, Bioorganic & Medicinal Chemistry Letters, 2010, Wang, Tingting et. al.
Orally active PDE4 inhibitor with therapeutic potential
score: 1.6780811, European Journal of Medicinal Chemistry, 2004, Ochiai, Hiroshi et. al.
Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines
score: 1.6780137, European Journal of Medicinal Chemistry, 2003, Ren, Hongyu et. al.
Design and synthesis of orally active benzamide derivatives as potent serotonin 4 receptor agonist
score: 1.6776143, Bioorganic & Medicinal Chemistry, 2003, Sonda, Shuji et. al.
Rhodamine-based fluorogenic probe for imaging biological thiol
score: 1.6775153, Bioorganic & Medicinal Chemistry Letters, 2008, Shibata, Aya et. al.
New naphthylcombretastatins. Modifications on the ethylene bridge
score: 1.6774799, Bioorganic & Medicinal Chemistry, 2005, Sánchez Maya, Ana B. et. al.
Synthesis and evaluation of a cyclic imine derivative conjugated to a fluorescent molecule for labeling of proteins
score: 1.6774297, Bioorganic & Medicinal Chemistry Letters, 2009, Guo, Hai-Ming; Minakawa, Maki; Ueno, Lynn; Tanaka, Fujie
New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity
score: 1.6773928, Bioorganic & Medicinal Chemistry, 2006, Džubák, Petr et. al.
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position
score: 1.6772891, Bioorganic & Medicinal Chemistry Letters, 2012, Hamada, Yoshio et. al.
Synthesis of nucleoside-based antiviral drugs in ionic liquids
score: 1.677254, Bioorganic & Medicinal Chemistry Letters, 2008, Kumar, Vineet; Malhotra, Sanjay V.
Chemoinformatics: A view of the field and current trends in method development
score: 1.6772529, Bioorganic & Medicinal Chemistry, 2012, Vogt, Martin; Bajorath, Jürgen
Chemoinformatics: A view of the field and current trends in method development
score: 1.6772529, Bioorganic & Medicinal Chemistry, 2012, Vogt, Martin; Bajorath, Jürgen
Novel multi-functional nitrones for treatment of ischemic stroke
score: 1.6769738, Bioorganic & Medicinal Chemistry, 2012, Sun, Yewei et. al.
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity
score: 1.6767795, Bioorganic & Medicinal Chemistry Letters, 2012, Peña, Stella et. al.
New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure–activity relationships
score: 1.6767208, European Journal of Medicinal Chemistry, 2012, Areias, Filipe et. al.
Lignopurines: A new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation
score: 1.6766986, European Journal of Medicinal Chemistry, 2012, Castro, M et. al.
Lignopurines: A new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation
score: 1.6766986, European Journal of Medicinal Chemistry, 2012, Castro, M et. al.
Lignopurines: A new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation
score: 1.6766986, European Journal of Medicinal Chemistry, 2012, Castro, M et. al.
Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activities.
score: 1.6765819, Antimicrobial agents and chemotherapy, 2003, Ancelin, Marie L et. al.
Synthesis of an immunosuppressant SQAG9 and determination of the binding peptide by T7 phage display
score: 1.6764943, Bioorganic & Medicinal Chemistry Letters, 2004, Yamazaki, Takayuki et. al.
A suitable 1,2,4-oxadiazoles synthesis by microwave irradiation
score: 1.6763523, Bioorganic & Medicinal Chemistry Letters, 2004, Santagada, Vincenzo et. al.
aziridinyl peptides as inhibitors of cysteine proteases: Effect of a free carboxylic acid function on inhibition
score: 1.6762408, Bioorganic & Medicinal Chemistry, 2000, Schirmeister, T.; Peric, M.
Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents
score: 1.6761888, Bioorganic & Medicinal Chemistry, 2004, Kamal, Ahmed et. al.
Assay and inhibition of diacylglycerol lipase activity
score: 1.6760636, Bioorganic & Medicinal Chemistry Letters, 2012, Johnston, Meghan et. al.
Assay and inhibition of diacylglycerol lipase activity
score: 1.6760636, Bioorganic & Medicinal Chemistry Letters, 2012, Johnston, Meghan et. al.
Discovery of novel modulators of metabotropic glutamate receptor subtype-5
score: 1.6760203, Bioorganic & Medicinal Chemistry, 2004, Wang, Bowei et. al.
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists
score: 1.6758246, Bioorganic & Medicinal Chemistry, 2006, Xu, Ruo et. al.
Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase
score: 1.675576, Bioorganic & Medicinal Chemistry, 1998, Vig, Rakesh et. al.
A non-calcemic sulfone version of the vitamin D 3 analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin
score: 1.6754764, Bioorganic & Medicinal Chemistry, 2001, Posner, Gary H. et. al.
Synthesis and bioevaluation of glycosyl ureas as α-glucosidase inhibitors and their effect on mycobacterium
score: 1.6752154, Bioorganic & Medicinal Chemistry, 2003, Tewari, Neetu et. al.
A new class of HIV-1 protease inhibitor: The crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere
score: 1.6750994, Bioorganic & Medicinal Chemistry, 1996, Rutenber, Earl E. et. al.
3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: a novel class of central nicotinic receptor ligands
score: 1.6749195, Bioorganic & Medicinal Chemistry, 1998, Olesen, Preben H.; Swedberg, Michael D.B.; Rimvall, Karin
Furoxan analogues of the histamine H 3-receptor antagonist imoproxifan and related furazan derivatives
score: 1.6746112, Bioorganic & Medicinal Chemistry, 2005, Tosco, Paolo et. al.
Synthesis and biological activity of A- nor-paclitaxel analogues
score: 1.6745633, Bioorganic & Medicinal Chemistry, 1997, Chordia, Mahendra D. et. al.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
score: 1.6745386, Bioorganic & Medicinal Chemistry Letters, 2012, Yen, Chiao-Ting et. al.
Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors
score: 1.6742323, Bioorganic & Medicinal Chemistry, 2006, Tanaka, Masahiro et. al.
Chemoinformatics: A view of the field and current trends in method development
score: 1.674133, Bioorganic & Medicinal Chemistry, 2012, Vogt, Martin; Bajorath, Jürgen
Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents
score: 1.6740776, Bioorganic & Medicinal Chemistry Letters, 2012, Dulla, Balakrishna et. al.
Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents
score: 1.6740776, Bioorganic & Medicinal Chemistry Letters, 2012, Dulla, Balakrishna et. al.
Rational design of anticytoadherence inhibitors for Plasmodium falciparum based on the crystal structure of human intercellular adhesion molecule 1.
score: 1.6739798, Antimicrobial agents and chemotherapy, 2006, Dormeyer, Matthias et. al.
Laurene-type sesquiterpenes from the Red Sea red alga Laurencia obtusa as potential antitumor–antimicrobial agents
score: 1.6739275, European Journal of Medicinal Chemistry, 2012, Alarif, Walied M. et. al.
Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani
score: 1.6738513, Bioorganic & Medicinal Chemistry Letters, 2012, Gohil, Vikrantsinh M. et. al.
Synthesis and structure-activity relationship of disubstituted benzamides as a novel class of antimalarial agents
score: 1.6737585, Bioorganic & Medicinal Chemistry Letters, 2012, Mitachi, Katsuhiko et. al.
Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine
score: 1.6737312, Bioorganic & Medicinal Chemistry, 2004, Caron, Giulia et. al.
Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors
score: 1.673515, Bioorganic & Medicinal Chemistry, 1996, Faerman, Carlos H. et. al.
Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine
score: 1.6734594, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Wukun et. al.
DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties
score: 1.6734023, Bioorganic & Medicinal Chemistry Letters, 1998, Takahashi, Takashi et. al.
Substituted phenanthrenes with basic amino side chains: A new series of anti-breast cancer agents
score: 1.6733126, Bioorganic & Medicinal Chemistry, 2006, Shagufta, et. al.
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors
score: 1.6731698, Bioorganic & Medicinal Chemistry Letters, 2012, Luniewski, Wojciech et. al.
Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors
score: 1.6730998, Bioorganic & Medicinal Chemistry, 2012, Ross-Macdonald, Petra et. al.
Optimization of the binding properties of PNA-(5′)-DNA chimerae
score: 1.6730725, Bioorganic & Medicinal Chemistry Letters, 1998, van der Laan, A.C et. al.
Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives
score: 1.672988, Bioorganic & Medicinal Chemistry, 2006, Ghidini, Eleonora et. al.
In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.
score: 1.6728736, Antimicrobial agents and chemotherapy, 2008, Fernandes Rodrigues, Juliany Cola et. al.
Design, synthesis and biological evaluation of novel non-nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties
score: 1.6725671, Bioorganic & Medicinal Chemistry, 2004, Sriram, Dharmarajan et. al.
Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents
score: 1.6724947, Bioorganic & Medicinal Chemistry, 2012, Yao, Jianwen; Chen, Jing; He, Zuopeng; Sun, Wei; Xu, Wenfang
Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents
score: 1.6724947, Bioorganic & Medicinal Chemistry, 2012, Yao, Jianwen; Chen, Jing; He, Zuopeng; Sun, Wei; Xu, Wenfang
Novel multipotent phenylthiazole–tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload
score: 1.6724848, Bioorganic & Medicinal Chemistry, 2012, Wang, Yue et. al.
Novel multipotent phenylthiazole–tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload
score: 1.6724848, Bioorganic & Medicinal Chemistry, 2012, Wang, Yue et. al.
Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV.
score: 1.6722857, Antimicrobial agents and chemotherapy, 2009, Pan, Xiao-Su; Gould, Katherine A; Fisher, L Mark
Fully automated synthesis and initial PET evaluation of [ 11C]PBR28
score: 1.6721786, Bioorganic & Medicinal Chemistry Letters, 2009, Wang, Min et. al.
Synthesis of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D 2 and D 3 receptors
score: 1.6721496, Bioorganic & Medicinal Chemistry, 2001, Huang, Yunsheng et. al.
NMR conformational analysis of p-tolyl furanopyrimidine 2′-deoxyribonucleoside and crystal structure of its 3′,5′-di- O-acetyl derivative
score: 1.6721119, Bioorganic & Medicinal Chemistry, 2005, Esho, Noor et. al.
Synthesis and antimycobacterial activity of calpinactam derivatives
score: 1.672066, Bioorganic & Medicinal Chemistry Letters, 2012, Nagai, Kenichiro et. al.
Synthesis and antimycobacterial activity of calpinactam derivatives
score: 1.672066, Bioorganic & Medicinal Chemistry Letters, 2012, Nagai, Kenichiro et. al.
Synthesis and antimycobacterial activity of calpinactam derivatives
score: 1.672066, Bioorganic & Medicinal Chemistry Letters, 2012, Nagai, Kenichiro et. al.
Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis
score: 1.6717791, Bioorganic & Medicinal Chemistry Letters, 2012, Jung, Suk-Kyeong et. al.
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors
score: 1.6716322, European Journal of Medicinal Chemistry, 2012, Gu, Shuang-Xi et. al.
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors
score: 1.6716322, European Journal of Medicinal Chemistry, 2012, Gu, Shuang-Xi et. al.
Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate
score: 1.6714864, Bioorganic & Medicinal Chemistry Letters, 2012, Suneela, Dhaneshwar; Dipmala, Patil
Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate
score: 1.6714864, Bioorganic & Medicinal Chemistry Letters, 2012, Suneela, Dhaneshwar; Dipmala, Patil
Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate
score: 1.6714864, Bioorganic & Medicinal Chemistry Letters, 2012, Suneela, Dhaneshwar; Dipmala, Patil
Inhibition of Adamalysin II and MMPs by Phosphonate Analogues of Snake Venom Peptides
score: 1.6712398, Bioorganic & Medicinal Chemistry, 1999, D’Alessio, Silvana et. al.
Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones.
score: 1.6712345, Antimicrobial agents and chemotherapy, 2004, Zervosen, Astrid et. al.
Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: remarkable effects of 2α-methyl introduction on antagonistic activity
score: 1.671121, Bioorganic & Medicinal Chemistry, 2003, Fujishima, Toshie et. al.
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives
score: 1.6710527, Bioorganic & Medicinal Chemistry, 2004, Tian, Zong-Qiang et. al.
Synthesis and structure–activity correlations of the cytotoxic bifunctional 1,4-diamidoanthraquinone derivatives
score: 1.6709305, Bioorganic & Medicinal Chemistry, 2004, Huang, Hsu-Shan et. al.
Structure–activity relationship of cinnamic acylsulfonamide analogues on the human EP 3 prostanoid receptor
score: 1.6708676, Bioorganic & Medicinal Chemistry, 2001, Juteau, Hélène et. al.
A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan
score: 1.6703809, Bioorganic & Medicinal Chemistry, 2006, Cordero-Vargas, Alejandro et. al.
Identification of inhibitors of heparin–growth factor interactions from combinatorial libraries of four-component condensation reactions
score: 1.6700159, Bioorganic & Medicinal Chemistry, 2001, Zhang, Jundong et. al.
Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl- l-prolyl- l-glutamic acid (GPE)
score: 1.6700104, Bioorganic & Medicinal Chemistry, 2005, Lai, Michelle Y.H. et. al.
An efficient, simple and expedition synthesis of 1-amidoalkyl-2-naphthols as ‘drug like’ molecules for biological screening
score: 1.6698569, Bioorganic & Medicinal Chemistry Letters, 2008, Shaterian, Hamid Reza; Yarahmadi, Hossein; Ghashang, Majid
Synthesis and structure–activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study
score: 1.6697901, Bioorganic & Medicinal Chemistry, 2005, Kuramochi, Takahiro et. al.
An example of designed multiple ligands spanning protein classes: Dual MCH-1R antagonists/DPPIV inhibitors
score: 1.6695428, Bioorganic & Medicinal Chemistry Letters, 2012, Gattrell, William T. et. al.
Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery
score: 1.6695, Bioorganic & Medicinal Chemistry Letters, 2006, Kadam, Rameshwar U.; Kiran, V.M.; Roy, Nilanjan
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B
score: 1.6692611, Bioorganic & Medicinal Chemistry, 2005, Pan, Xulin et. al.
Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding.
score: 1.6691969, Antimicrobial agents and chemotherapy, 2009, Sheng, Chunquan et. al.
Fluorescent sodium ion indicators based on the 1,7-diaza-15-crown-5 system
score: 1.6691173, Bioorganic & Medicinal Chemistry Letters, 2004, Martin, Vladimir V. et. al.
Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals
score: 1.6690002, Bioorganic & Medicinal Chemistry, 2003, Johansson, Anja et. al.
Classical and three-dimensional QSAR for the inhibition of [ 3H]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells
score: 1.6688915, Bioorganic & Medicinal Chemistry, 2005, Nakagawa, Yoshiaki et. al.
Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene
score: 1.668653, Bioorganic & Medicinal Chemistry, 2012, Murasawa, Shinpei et. al.
Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene
score: 1.668653, Bioorganic & Medicinal Chemistry, 2012, Murasawa, Shinpei et. al.
Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands
score: 1.6685756, Bioorganic & Medicinal Chemistry, 2012, Ida, Yoshihiro et. al.
Lanthanide(III) complexes of pyridine–tetraacetic acid-glycoconjugates: Synthesis and luminescence studies of mono and divalent derivatives
score: 1.6684457, Bioorganic & Medicinal Chemistry Letters, 2012, Gouin, Sébastien G. et. al.
Synthesis of 2-(aminocarbonylmethylthio)-1 H-imidazoles as novel Capravirine analogues
score: 1.6683498, Bioorganic & Medicinal Chemistry, 2005, Loksha, Yasser M. et. al.
A novel one-pot three-component reaction: Synthesis of triheterocyclic 4 H-pyrimido[2,1- b]benzazoles ring systems
score: 1.6682245, Bioorganic & Medicinal Chemistry Letters, 2005, Shaabani, Ahmad; Rahmati, Abbas; Naderi, Soheila
Synthesis and biological evaluation of (2 S)- and (2 R)-2-(3′-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands
score: 1.6680865, Bioorganic & Medicinal Chemistry, 2006, Filosa, Rosanna et. al.
Synthesis and in Vitro Antiproliferative Activity of New 11-Aminoalkylamino-Substituted Chromeno[2,3-b]indoles
score: 1.6679735, European Journal of Medicinal Chemistry, 2012, Peng, Wei et. al.
ERβ Ligands. Part 2: Synthesis and structure–activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives
score: 1.6679359, Bioorganic & Medicinal Chemistry, 2004, Yang, Cuijian et. al.
QSAR study on 5-lipoxygenase inhibitors using distance-Based topological indices
score: 1.6677855, Bioorganic & Medicinal Chemistry, 2003, Agrawal, Vijay K.; Bano, Shahnaz; Khadikar, Padmakar V.
Thieno[3,2-c]pyran-4-one based novel small molecules: Their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents
score: 1.6675136, Bioorganic & Medicinal Chemistry Letters, 2012, Nakhi, Ali et. al.
Thieno[3,2-c]pyran-4-one based novel small molecules: Their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents
score: 1.6675136, Bioorganic & Medicinal Chemistry Letters, 2012, Nakhi, Ali et. al.
Thieno[3,2-c]pyran-4-one based novel small molecules: Their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents
score: 1.6675136, Bioorganic & Medicinal Chemistry Letters, 2012, Nakhi, Ali et. al.
Application of a trifunctional reactive linker for the construction of antibody–drug hybrid conjugates
score: 1.6670537, Bioorganic & Medicinal Chemistry Letters, 2008, Thomas, Joshua D. et. al.
Structure-activity Relationships of saponin derivatives: A series of entry inhibitors for highly pathogenic H5N1 Influenza virus
score: 1.667038, European Journal of Medicinal Chemistry, 2012, Ding, Ning et. al.
Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities
score: 1.6669897, Bioorganic & Medicinal Chemistry, 1999, Han, Yi Fan et. al.
Development of a novel albumin-binding prodrug that is cleaved by urokinase-type-plasminogen activator (uPA)
score: 1.6666669, Bioorganic & Medicinal Chemistry Letters, 2006, Chung, Da-Eun; Kratz, Felix
Biosynthetic origin of hygromycin A.
score: 1.6666181, Antimicrobial agents and chemotherapy, 2003, Habib, El-Sayed E; Scarsdale, J Neel; Reynolds, Kevin A
Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca 2+ channels and nicotinic receptors
score: 1.6665994, Bioorganic & Medicinal Chemistry, 2004, Marco, José L et. al.
Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents
score: 1.6665452, European Journal of Medicinal Chemistry, 2012, Song, Ming-Xia et. al.
Synthesis of new 2,4-Diaminopyrido[2,3- d]pyrimidine and 2,4-Diaminopyrrolo[2,3- d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase
score: 1.6665317, Bioorganic & Medicinal Chemistry, 2003, Rosowsky, Andre; Chen, Han; Fu, Hongning; Queener, Sherry F.
Pyrrolo[2,3- d]pyrimidines and pyrido[2,3- d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim
score: 1.6664834, Bioorganic & Medicinal Chemistry, 1996, Kuyper, Lee F et. al.
Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
score: 1.6662269, Bioorganic & Medicinal Chemistry, 2012, Chen, Wei-Jia et. al.
Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
score: 1.6662269, Bioorganic & Medicinal Chemistry, 2012, Chen, Wei-Jia et. al.
Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
score: 1.6662269, Bioorganic & Medicinal Chemistry, 2012, Chen, Wei-Jia et. al.
‘Green’ methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid
score: 1.6660388, Bioorganic & Medicinal Chemistry, 2005, Prasad, Ashok K. et. al.
Dicationic dithiocarbamate carbapenems with anti-MRSA activity
score: 1.6659544, Bioorganic & Medicinal Chemistry, 2001, Imamura, Hideaki et. al.
Synthesis, anticonvulsant, and anti-inflammatory evaluation of some new benzotriazole and benzofuran-based heterocycles
score: 1.6659434, Bioorganic & Medicinal Chemistry, 2006, Dawood, Kamal M. et. al.
Synthesis of polyhydroxylated piperidines and evaluation as glycosidase inhibitors
score: 1.6657227, Bioorganic & Medicinal Chemistry, 2004, Tite, Tony et. al.
Conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site
score: 1.6655772, Bioorganic & Medicinal Chemistry, 2012, Varvarigou, Nicole et. al.
3-Deazaadenosine analogues of p5′A2′p5′A2′p5′A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L
score: 1.6654793, Bioorganic & Medicinal Chemistry, 2004, Kalinichenko, Elena N et. al.
Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety
score: 1.6654534, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Qing-Rong et. al.
Novel 2-(2-(Benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: Discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype
score: 1.6652206, Bioorganic & Medicinal Chemistry Letters, 2012, Pothier, Julien et. al.
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux
score: 1.6651465, Bioorganic & Medicinal Chemistry Letters, 2012, Kuriakose, Jerrin; Hrycyna, Christine A.; Chmielewski, Jean
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux
score: 1.6651465, Bioorganic & Medicinal Chemistry Letters, 2012, Kuriakose, Jerrin; Hrycyna, Christine A.; Chmielewski, Jean
Synthesis and characterization of novel hydrazide–hydrazones and the study of their structure–antituberculosis activity
score: 1.6651155, European Journal of Medicinal Chemistry, 2006, Bedia, Koçyiğit-Kaymakçıoğlu et. al.
Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity
score: 1.6649368, Bioorganic & Medicinal Chemistry Letters, 2013, Ruchelman, Alexander L. et. al.
Zn 2+ dependent DNA binders based on terminally modified peptide nucleic acids
score: 1.6647944, Bioorganic & Medicinal Chemistry Letters, 2006, Boll, Iris et. al.
Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection.
score: 1.6647585, Antimicrobial agents and chemotherapy, 2004, Cianci, Christopher et. al.
Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic marine dinoflagellate Symbiodinium sp.
score: 1.6644861, Bioorganic & Medicinal Chemistry, 2005, Kita, Masaki et. al.
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds
score: 1.6643569, Bioorganic & Medicinal Chemistry, 2012, Moraski, Garrett C. et. al.
Atom-based 3D-chiral quadratic indices. Part 2: Prediction of the corticosteroid-binding globulinbinding affinity of the 31 benchmark steroids data set
score: 1.6643261, Bioorganic & Medicinal Chemistry, 2006, Castillo-Garit, Juan A. et. al.
Benzoyl nitrogen mustard derivatives of benzoheterocyclic analogues of netropsin: Synthesis and biological activity
score: 1.6641089, Bioorganic & Medicinal Chemistry, 2003, Baraldi, Pier Giovanni et. al.
Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones
score: 1.664099, Bioorganic & Medicinal Chemistry, 2006, Das, Jagattaran et. al.
Novel azulene derivatives for the treatment of erectile dysfunction
score: 1.6640794, Bioorganic & Medicinal Chemistry Letters, 2012, Löber, Stefan et. al.
Novel azulene derivatives for the treatment of erectile dysfunction
score: 1.6640794, Bioorganic & Medicinal Chemistry Letters, 2012, Löber, Stefan et. al.
Novel azulene derivatives for the treatment of erectile dysfunction
score: 1.6640794, Bioorganic & Medicinal Chemistry Letters, 2012, Löber, Stefan et. al.
Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives
score: 1.6640533, European Journal of Medicinal Chemistry, 2005, Cao, R. et. al.
Synthesis of N6-alkyl(aryl)-2-alkyl(aryl)thioadenosines as antiplatelet agents
score: 1.6640154, European Journal of Medicinal Chemistry, 2012, Liu, Guocheng et. al.
Synthesis of N6-alkyl(aryl)-2-alkyl(aryl)thioadenosines as antiplatelet agents
score: 1.6640154, European Journal of Medicinal Chemistry, 2012, Liu, Guocheng et. al.
Synthesis of N6-alkyl(aryl)-2-alkyl(aryl)thioadenosines as antiplatelet agents
score: 1.6640154, European Journal of Medicinal Chemistry, 2012, Liu, Guocheng et. al.
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents
score: 1.6639856, Bioorganic & Medicinal Chemistry Letters, 2012, Meng, Fan-Chao et. al.
Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy
score: 1.6638972, Bioorganic & Medicinal Chemistry Letters, 2012, Serda, Maciej et. al.
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012
score: 1.6638318, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
Novel progesterone receptor modulators: 4-Aryl-phenylsulfonamides
score: 1.6630691, Bioorganic & Medicinal Chemistry Letters, 2012, McComas, Casey et. al.
Novel progesterone receptor modulators: 4-Aryl-phenylsulfonamides
score: 1.6630691, Bioorganic & Medicinal Chemistry Letters, 2012, McComas, Casey et. al.
Novel progesterone receptor modulators: 4-Aryl-phenylsulfonamides
score: 1.6630691, Bioorganic & Medicinal Chemistry Letters, 2012, McComas, Casey et. al.
Structure-Activity Relationship Exploration of Kv1.3 Blockers Based on Diphenoxylate
score: 1.6626992, Bioorganic & Medicinal Chemistry Letters, 2012, Nguyen, William et. al.
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model
score: 1.6624341, Bioorganic & Medicinal Chemistry, 2005, Sasaki, Kazue et. al.
Synthetic study on novel immunosuppressant KF20444
score: 1.662292, Bioorganic & Medicinal Chemistry, 2001, Chujo, Iwao et. al.
A fluorescent substrate for carbon–phosphorus lyase: Towards the pathway for organophosphonate metabolism in bacteria
score: 1.6621952, Bioorganic & Medicinal Chemistry Letters, 2009, He, Shu-Mei; Luo, Yan; Hove-Jensen, Bjarne; Zechel, David L.
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents
score: 1.6619734, Bioorganic & Medicinal Chemistry Letters, 2012, Meng, Fan-Chao et. al.
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents
score: 1.6619734, Bioorganic & Medicinal Chemistry Letters, 2012, Meng, Fan-Chao et. al.
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents
score: 1.6619734, Bioorganic & Medicinal Chemistry Letters, 2012, Meng, Fan-Chao et. al.
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2and serotonin 5-HT1Amulti-action profile
score: 1.6619006, Bioorganic & Medicinal Chemistry, 2013, Sun, Haifeng et. al.
Hybrids of sugars and aromatics: A Pd-catalyzed modular approach to chromans and isochromans
score: 1.6618079, Bioorganic & Medicinal Chemistry, 2010, Leibeling, Markus et. al.
Enzymatic synthesis of 8-vinyl- and 8-styryl-2’-deoxyguanosine modified DNA – novel fluorescent molecular probes
score: 1.6615488, Bioorganic & Medicinal Chemistry Letters, 2012, Holzberger, Bastian et. al.
Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors
score: 1.6612987, European Journal of Medicinal Chemistry, 2012, Wani, Mohmmad Younus et. al.
Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors
score: 1.6612987, European Journal of Medicinal Chemistry, 2012, Wani, Mohmmad Younus et. al.
Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): A target for heart failure and platelet aggregation
score: 1.6612956, Bioorganic & Medicinal Chemistry Letters, 2012, Ravinder, Mettu et. al.
Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation
score: 1.6612956, Bioorganic & Medicinal Chemistry Letters, 2012, Ravinder, Mettu et. al.
Potent agonists of the Hedgehog signaling pathway
score: 1.6612827, Bioorganic & Medicinal Chemistry Letters, 2009, Brunton, Shirley A. et. al.
Antitumor agents. Part 235: Novel 4′-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential
score: 1.6612517, Bioorganic & Medicinal Chemistry, 2004, Xiao, Zhiyan et. al.
Synthesis and antimicrobial activities of structurally novel S,S′-bis(hetero-substituted) disulfides
score: 1.6610933, Bioorganic & Medicinal Chemistry Letters, 2012, Ramaraju, Praveen et. al.
Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
score: 1.6610933, Bioorganic & Medicinal Chemistry Letters, 2012, Ramaraju, Praveen et. al.
Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
score: 1.6610933, Bioorganic & Medicinal Chemistry Letters, 2012, Ramaraju, Praveen et. al.
Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents
score: 1.6610538, Bioorganic & Medicinal Chemistry, 2000, Chung, Sung-Kee et. al.
A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs
score: 1.6610307, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang
Synthesis and in vitro antitubercular activity of 4-Aryl/alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis
score: 1.6609998, Bioorganic & Medicinal Chemistry Letters, 2012, Jeyachandran, Malaichamy et. al.
The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction
score: 1.6609461, Bioorganic & Medicinal Chemistry Letters, 2012, Furet, Pascal et. al.
The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction
score: 1.6609461, Bioorganic & Medicinal Chemistry Letters, 2012, Furet, Pascal et. al.
The extremo-α-carbonic anhydrase (CA) fromSulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines
score: 1.6608159, Bioorganic & Medicinal Chemistry Letters, 2013, Akdemir, Atilla et. al.
Active site-directed thrombin inhibitors-II. Studies related to arginine/guanidine bioisosteres
score: 1.6601529, Bioorganic & Medicinal Chemistry, 1995, St Laurent, D.R. et. al.
Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation
score: 1.6600132, Bioorganic & Medicinal Chemistry, 2003, Tobe, Masanori et. al.
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives
score: 1.6596129, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yingqian et. al.
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives
score: 1.6596129, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yingqian et. al.
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives
score: 1.6596129, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yingqian et. al.
New progesterone receptor antagonists: Phosphorus-containing 11β-aryl-substituted steroids
score: 1.6595844, Bioorganic & Medicinal Chemistry, 2006, Jiang, Weiqin et. al.
Convenient synthesis of l- proline benzyl ester
score: 1.6595267, Bioorganic & Medicinal Chemistry Letters, 1999, Córdova, Armando et. al.
An approach for differentiating isozymes. Construction of libraries containing short aromatic peptides as part of a method to design selective inhibitors against lipases
score: 1.6592529, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sangeun; Yu, Jaehoon
An approach for differentiating isozymes. Construction of libraries containing short aromatic peptides as part of a method to design selective inhibitors against lipases
score: 1.6592529, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Sangeun; Yu, Jaehoon
Microwave-assisted synthesis of dihydropyrimidin-2(1 H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst
score: 1.6591944, Bioorganic & Medicinal Chemistry Letters, 2008, Khabazzadeh, Hojatollah; Saidi, Kazem; Sheibani, Hassan
Molecular hybridization of bioactives: Synthesis and antitubercular evaluation of novel dibenzofuran embodied homoisoflavonoids via Baylis–Hillman reaction
score: 1.6588745, Bioorganic & Medicinal Chemistry Letters, 2012, Yempala, Thirumal et. al.
Molecular hybridization of bioactives: Synthesis and antitubercular evaluation of novel dibenzofuran embodied homoisoflavonoids via Baylis–Hillman reaction
score: 1.6588745, Bioorganic & Medicinal Chemistry Letters, 2012, Yempala, Thirumal et. al.
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides
score: 1.6588714, Bioorganic & Medicinal Chemistry Letters, 2008, Vlahov, Iontcho R. et. al.
Predictive models for hERG potassium channel blockers
score: 1.6587732, Bioorganic & Medicinal Chemistry Letters, 2005, Cianchetta, Giovanni et. al.
Chemotography for multi-target SAR analysis in the context of biological pathways
score: 1.6586476, Bioorganic & Medicinal Chemistry, 2012, Lounkine, Eugen et. al.
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors
score: 1.6585544, Bioorganic & Medicinal Chemistry Letters, 2012, Rambabu, D. et. al.
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors
score: 1.6585544, Bioorganic & Medicinal Chemistry Letters, 2012, Rambabu, D. et. al.
A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide
score: 1.6585543, European Journal of Medicinal Chemistry, 2005, Michaux, Catherine et. al.
Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives
score: 1.6585361, European Journal of Medicinal Chemistry, 2001, Grynkiewicz, Grzegorz et. al.
Core-modified porphyrins. Part 5: Electronic effects on photophysical and biological properties in vitro
score: 1.6585206, Bioorganic & Medicinal Chemistry, 2005, You, Youngjae; Gibson, Scott L.; Detty, Michael R.
Antimicrobial evaluation of nocathiacins, a thiazole peptide class of antibiotics.
score: 1.6584734, Antimicrobial agents and chemotherapy, 2004, Pucci, Michael J et. al.
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1
score: 1.6582365, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Zhongsheng et. al.
Synthesis and protein binding properties of T-antigen containing GlycoPAMAM dendrimers
score: 1.6579363, Bioorganic & Medicinal Chemistry, 2002, Baek, Myung-Gi; Roy, René
Total synthesis and evaluation of lamellarin α 20-Sulfate analogues
score: 1.6578932, Bioorganic & Medicinal Chemistry, 2002, Ridley, Christian P et. al.
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
score: 1.657891, European Journal of Medicinal Chemistry, 2012, Marhadour, Sophie et. al.
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
score: 1.657891, European Journal of Medicinal Chemistry, 2012, Marhadour, Sophie et. al.
Prevention and treatment of Staphylococcus aureus pneumonia with a beta-cyclodextrin derivative.
score: 1.6577708, Antimicrobial agents and chemotherapy, 2010, Ragle, Brook E et. al.
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain
score: 1.6574277, Bioorganic & Medicinal Chemistry, 2000, Casimiro-Garcia, Agustin et. al.
Discovery of 2-Phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors
score: 1.6573797, Bioorganic & Medicinal Chemistry, 2003, Hu, Wenhui et. al.
An integrated approach for identification and target validation of antifungal compounds active against Erg11p.
score: 1.6572736, Antimicrobial agents and chemotherapy, 2012, Hoepfner, Dominic et. al.
Photoisomerization as a trigger for Bergman cyclization: Synthesis and reactivity of azoenediynes
score: 1.6571338, Bioorganic & Medicinal Chemistry Letters, 2005, Kar, Moumita; Basak, Amit; Bhattacharjee, Manish
Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation
score: 1.656994, Bioorganic & Medicinal Chemistry, 2006, Elsner, Jan et. al.
Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy
score: 1.6565971, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xiu-Jun et. al.
Structure-Based Virtual Screening for Drug Discovery: a Problem-Centric Review
score: 1.6565752, The AAPS Journal, 2012, Cheng, Tiejun et. al.
Iodine scanning of a phenazine inhibitor of vacuolar sorting
score: 1.6563768, Bioorganic & Medicinal Chemistry Letters, 2010, Surpin, Marci et. al.
Metabolites of Orally Active NO-Independent Pyrazolopyridine Stimulators of Soluble Guanylate Cyclase
score: 1.6563328, Bioorganic & Medicinal Chemistry, 2002, Straub, Alexander et. al.
CYP3A4 Inhibitory Activity of New Bisalkaloids, Dipiperamides D and E, and Cognates from White Pepper
score: 1.6561306, Bioorganic & Medicinal Chemistry, 2002, Tsukamoto, Sachiko et. al.
Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.
score: 1.6560602, Antimicrobial agents and chemotherapy, 2012, Frey, Kathleen M et. al.
Semisynthesis of heterocyclic analogues of squamocin, a cytotoxic annonaceous acetogenin, by an unusual oxidative decarboxylation reaction
score: 1.6560419, Bioorganic & Medicinal Chemistry, 2003, Duval, R; Lewin, G; Hocquemiller, R
Ginkgolides and bilobalide: Their physical, chromatographic and spectroscopic properties
score: 1.6559462, Bioorganic & Medicinal Chemistry, 2005, van Beek, Teris A.
A new drug-release method using the Staudinger ligation
score: 1.6559112, Bioorganic & Medicinal Chemistry Letters, 2006, Azoulay, Michel et. al.
A new benzil derivative from Derris scandens: Structure-insecticidal activity study
score: 1.6558774, Bioorganic & Medicinal Chemistry Letters, 2010, Sreelatha, T. et. al.
Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide
score: 1.6555586, Bioorganic & Medicinal Chemistry Letters, 2005, Seo, Jai Woong et. al.
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model
score: 1.6555149, Bioorganic & Medicinal Chemistry Letters, 2012, Banerjee, Abhisek et. al.
Synthesis and antileishmanial activities of novel 3-substituted quinolines.
score: 1.6553024, Antimicrobial agents and chemotherapy, 2005, Tempone, André Gustavo et. al.
Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors
score: 1.6552623, European Journal of Medicinal Chemistry, 2012, Kalirajan, R.; Kulshrestha, Vivek; Sankar, S.; Jubie, S.
Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors
score: 1.6552623, European Journal of Medicinal Chemistry, 2012, Kalirajan, R.; Kulshrestha, Vivek; Sankar, S.; Jubie, S.
Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases
score: 1.6551585, Bioorganic & Medicinal Chemistry, 2005, Zheng, Hailin et. al.
On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia
score: 1.6551539, Bioorganic & Medicinal Chemistry Letters, 2008, Mallia, Madhava B. et. al.
High affinity central benzodiazepine receptor ligands: synthesis and structure–activity relationship studies of a new series of pyrazolo[4,3- c]quinolin-3-ones
score: 1.6549817, Bioorganic & Medicinal Chemistry, 1998, Savini, L. et. al.
Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis—radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib
score: 1.6540876, Bioorganic & Medicinal Chemistry Letters, 2012, Kuchar, Manuela et. al.
N-Hydroxy sulfonimidamides as new nitroxyl (HNO) donors
score: 1.653972, Bioorganic & Medicinal Chemistry Letters, 2005, Pennington, Richard L.; Sha, Xin; King, S. Bruce
Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.
score: 1.653873, Antimicrobial agents and chemotherapy, 2012, Li, Mei et. al.
Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT 1A receptor agonists with neuroprotective effect: Discovery of Piclozotan
score: 1.6538179, Bioorganic & Medicinal Chemistry, 2006, Kamei, Katsuhide et. al.
3-Amino-2-hydroxy-propionaldehyde and 3-amino-1-hydroxypropan-2-one derivatives: New classes of aminopeptidase inhibitors
score: 1.6538049, Bioorganic & Medicinal Chemistry, 1996, Tarnus, Céline; Rémy, Jean-Marc; d'Orchymont, Hugues
Discovery of a novel lead structure for anti-malarials
score: 1.6537222, Bioorganic & Medicinal Chemistry, 2001, Wiesner, Jochen et. al.
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors
score: 1.6536275, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Kyeong et. al.
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors
score: 1.6536275, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Kyeong et. al.
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors
score: 1.6536275, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Kyeong et. al.
Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moiety
score: 1.6532749, Bioorganic & Medicinal Chemistry Letters, 2012, Animati, Fabio et. al.
Participation of the conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide
score: 1.6529914, Bioorganic & Medicinal Chemistry, 2000, Murakami, Nobutoshi et. al.
Antioxidant and anti-inflammatory activities of N-acetyldopamine dimers from Periostracum Cicadae
score: 1.652989, Bioorganic & Medicinal Chemistry, 2006, Xu, Ming-Zhe et. al.
Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
score: 1.6529318, European Journal of Medicinal Chemistry, 2012, Mourad, Mai A.E. et. al.
Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
score: 1.6529318, European Journal of Medicinal Chemistry, 2012, Mourad, Mai A.E. et. al.
Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes
score: 1.6529294, Bioorganic & Medicinal Chemistry, 2004, Priego, Eva-Marı́a et. al.
Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein E production
score: 1.6528355, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Mandeep et. al.
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening
score: 1.6527386, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Angeline C.-H. et. al.
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening
score: 1.6527386, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Angeline C.-H. et. al.
Further exploration of M1 allosteric agonists: Subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism
score: 1.6526919, Bioorganic & Medicinal Chemistry Letters, 2013, Sheffler, Douglas J. et. al.
An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1
score: 1.652685, Bioorganic & Medicinal Chemistry Letters, 2012, Wilfong, Erin M.; Du, Yu; Toone, Eric J.
New 2, N 6-Disubstituted adenosines: potent and selective A 1 adenosine receptor agonists
score: 1.6525362, Bioorganic & Medicinal Chemistry, 2002, Hutchinson, Sally A; Baker, Stephen P; Scammells, Peter J
Aza analogues of thalidomide
score: 1.6523548, Bioorganic & Medicinal Chemistry, 2001, Gütschow, Michael et. al.
The first stereoselective total synthesis of (Z)-cryptomoscatone D2, a natural G2 checkpoint inhibitor
score: 1.6522194, Bioorganic & Medicinal Chemistry Letters, 2012, Chinna Reddy, Gandolla et. al.
Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives
score: 1.6521778, European Journal of Medicinal Chemistry, 2012, Liu, Jingbao et. al.
Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives
score: 1.6521778, European Journal of Medicinal Chemistry, 2012, Liu, Jingbao et. al.
Four analogues of spiroleptosphol isolated from Leptosphaeria doliolum
score: 1.6521082, Bioorganic & Medicinal Chemistry, 2009, Murakami, Takanori et. al.
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors
score: 1.6521003, Bioorganic & Medicinal Chemistry, 2006, Albrecht, Sébastien et. al.
New Diterpene Furanoids from the Antarctic Lichen Huea sp
score: 1.6520849, Bioorganic & Medicinal Chemistry Letters, 2012, Cui, Yinglan et. al.
Novel diamide insecticides: Sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives
score: 1.651753, Bioorganic & Medicinal Chemistry Letters, 2012, Gnamm, Christian et. al.
Novel diamide insecticides: Sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives
score: 1.651753, Bioorganic & Medicinal Chemistry Letters, 2012, Gnamm, Christian et. al.
Novel diamide insecticides: Sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives
score: 1.651753, Bioorganic & Medicinal Chemistry Letters, 2012, Gnamm, Christian et. al.
Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins
score: 1.6517253, Bioorganic & Medicinal Chemistry, 2004, Shiyama, Takaaki et. al.
Novel Diamide Insecticides: Sulfoximines, Sulfonimidamides and Other New Sulfonimidoyl Derivatives
score: 1.6516634, Bioorganic & Medicinal Chemistry Letters, 2012, Gnamm, Christian et. al.
In vivo activity of an azole series of CCR2 antagonists
score: 1.6515579, Bioorganic & Medicinal Chemistry Letters, 2012, Smethurst, Chris A. et. al.
In vivo activity of an azole series of CCR2 antagonists
score: 1.6515579, Bioorganic & Medicinal Chemistry Letters, 2012, Smethurst, Chris A. et. al.
In vivo activity of an azole series of CCR2 antagonists
score: 1.6515579, Bioorganic & Medicinal Chemistry Letters, 2012, Smethurst, Chris A. et. al.
A novel non-stochastic quadratic fingerprints-based approach for the ‘in silico’ discovery of new antitrypanosomal compounds
score: 1.6514865, Bioorganic & Medicinal Chemistry, 2005, Montero-Torres, Alina et. al.
The SAR analysis of TRPV1 agonists with the α-methylated B-region
score: 1.6514306, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Yongsung et. al.
Synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring
score: 1.6511991, Bioorganic & Medicinal Chemistry, 2004, Jo, Yeong Woo et. al.
Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin
score: 1.6511939, Bioorganic & Medicinal Chemistry Letters, 2012, Lal, Jaggi; Gupta, S.K.; Thavaselvam, D.; Agarwal, D.D.
CCLab—a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design
score: 1.6510028, Bioorganic & Medicinal Chemistry Letters, 2012, Fang, Guanghua et. al.
Novel cisplatin-type platinum complexes and their cytotoxic activity
score: 1.6509976, Bioorganic & Medicinal Chemistry Letters, 2006, Cui, Kai et. al.
Antiangiogenic and antitumor agents
score: 1.6508517, Bioorganic & Medicinal Chemistry, 2003, Gangjee, Aleem; Yang, Jie; Ihnat, Michael A.; Kamat, Shekhar
Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures.
score: 1.6508098, Antimicrobial agents and chemotherapy, 2011, Lemm, Julie A et. al.
Structure–activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action
score: 1.6507919, Bioorganic & Medicinal Chemistry Letters, 2012, Thur, Yithachu et. al.
Synthesis and biological evaluation of five-Membered heterocycles fused to cyclopenta[ c]thiophene as new antitumor agents
score: 1.6507781, Bioorganic & Medicinal Chemistry, 2003, Dallemagne, Patrick et. al.
Bis-4-aminoquinolines: novel triple-helix DNA intercalators and antagonists of immunostimulatory CpG-oligodeoxynucleotides
score: 1.6504666, Bioorganic & Medicinal Chemistry, 2003, Strekowski, Lucjan et. al.
Synthesis and evaluation of α-hydroxymethylated conjugated nitroalkenes for their anticancer activity: Inhibition of cell proliferation by targeting microtubules
score: 1.6504548, Bioorganic & Medicinal Chemistry, 2006, Mohan, Renu et. al.
New serine protease inhibitors with leukotriene B 4 (LTB 4) receptor binding affinity
score: 1.6501044, Bioorganic & Medicinal Chemistry, 1997, Nakayama, Yoshisuke et. al.
Orally available pyridinylpyrimidine derivatives as novel RANKL-induced osteoclastogenesis inhibitors
score: 1.6501022, Bioorganic & Medicinal Chemistry Letters, 2012, Miyata, Junji et. al.
Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors
score: 1.6500717, European Journal of Medicinal Chemistry, 2012, Ha, Young Mi et. al.
Mode-of-action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus.
score: 1.6500109, Antimicrobial agents and chemotherapy, 2011, Menzel, Thomas M et. al.
4,5-Dialkylsubstituted 2-imino-1,3-thiazolidine derivatives as potent inducible nitric oxide synthase inhibitors
score: 1.6500015, Bioorganic & Medicinal Chemistry, 2004, Ueda, Shigeo et. al.
Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-Trisubstituted dihydroisoquinolines and isoquinolines
score: 1.6497528, Bioorganic & Medicinal Chemistry, 2003, Batra, Sanjay et. al.
Quinazolines revisited: search for novel anxiolytic and GABAergic agents
score: 1.6496938, Bioorganic & Medicinal Chemistry Letters, 2005, Goel, R.K.; Kumar, Vipan; Mahajan, M.P.
Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D 3
score: 1.6495958, Bioorganic & Medicinal Chemistry, 2005, Posner, Gary H. et. al.
Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers
score: 1.649476, Bioorganic & Medicinal Chemistry, 2005, Göblyös, Anikó et. al.
A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites.
score: 1.6494753, Antimicrobial agents and chemotherapy, 2005, Spry, Christina et. al.
Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1,3-thiazole analogs
score: 1.6493767, Bioorganic & Medicinal Chemistry Letters, 2012, Hassan, Ghada S. et. al.
Effect of 3–5 monocyclizations of angiotensin II and 4-AminoPhe 6-Ang II on AT 2 receptor affinity
score: 1.6492628, Bioorganic & Medicinal Chemistry, 2003, Lindman, Susanna et. al.
Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists
score: 1.6492257, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists
score: 1.6492257, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists
score: 1.6492257, Bioorganic & Medicinal Chemistry Letters, 2012, Nitta, Aiko et. al.
Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket
score: 1.6491062, Bioorganic & Medicinal Chemistry Letters, 2012, Maryanoff, Bruce E. et. al.
New water soluble pyrroloquinoline derivatives as new potential anticancer agents
score: 1.64895, Bioorganic & Medicinal Chemistry, 2005, Ferlin, Maria Grazia et. al.
Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α1-adrenoceptor affinities
score: 1.6489011, Bioorganic & Medicinal Chemistry, 2012, Handzlik, Jadwiga et. al.
4-deoxyannomontacin and (2,4- cis and trans)-annomontacinone, new bioactive mono-tetrahydrofuran annonaceous acetogenins from Goniothalamus giganteus
score: 1.6486513, Bioorganic & Medicinal Chemistry, 1997, Alali, Feras et. al.
Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs
score: 1.6485494, Bioorganic & Medicinal Chemistry Letters, 2012, Ngoc, Tran Minh et. al.
Molecular modeling studies of novel retro-binding tripeptide active-site inhibitors of thrombin
score: 1.648462, Bioorganic & Medicinal Chemistry, 1995, Lau, Wan F. et. al.
Synthesis of 7-oxo-7 H-naphtho[1,2,3- de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines
score: 1.6484415, Bioorganic & Medicinal Chemistry, 2006, Dzieduszycka, Maria et. al.
Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interaction
score: 1.6481051, Bioorganic & Medicinal Chemistry Letters, 2012, Palmer, Cynthia et. al.
Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interaction
score: 1.6481051, Bioorganic & Medicinal Chemistry Letters, 2012, Palmer, Cynthia et. al.
Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interaction
score: 1.6481051, Bioorganic & Medicinal Chemistry Letters, 2012, Palmer, Cynthia et. al.
Tricyclic cyanoguanidines: synthesis, site of action and insecticidal activity of a novel class of reversible acetylcholinesterase inhibitors
score: 1.6480693, Bioorganic & Medicinal Chemistry, 2002, Finkelstein, Bruce L. et. al.
Vinylogous amide analogs of methylphenidate
score: 1.6480648, Bioorganic & Medicinal Chemistry Letters, 2005, Froimowitz, Mark et. al.
Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1.
score: 1.6480185, Antimicrobial agents and chemotherapy, 1999, Corbett, J W et. al.
Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers
score: 1.6480159, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng; Miller, Marvin J.
Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers
score: 1.6480159, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng; Miller, Marvin J.
Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers
score: 1.6480159, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng; Miller, Marvin J.
Synthesis of some novel pyrazolo[3,4- d]pyrimidine derivatives as potential antimicrobial agents
score: 1.6479731, Bioorganic & Medicinal Chemistry, 2006, Holla, Bantwal Shivarama et. al.
Synthesis and biological evaluation of 3′-Carboranyl thymidine analogues
score: 1.6475589, Bioorganic & Medicinal Chemistry Letters, 2002, Yan, Junhua et. al.
Antitumor agents 222. † † For Part 221, see ref 1. Synthesis and anti-androgen activity of new diarylheptanoids
score: 1.6474956, Bioorganic & Medicinal Chemistry, 2003, Ohtsu, Hironori et. al.
Artepillin C isoprenomics: Design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity
score: 1.647319, Bioorganic & Medicinal Chemistry, 2006, Uto, Yoshihiro et. al.
Synthesis and neuropharmacological evaluation of R(−)- N-alkyl-11-hydroxynoraporphines and their esters
score: 1.6472585, Bioorganic & Medicinal Chemistry, 2004, Csutoras, Csaba et. al.
From a cytotoxic agent to the discovery of a novel antimalarial agent
score: 1.6471485, Bioorganic & Medicinal Chemistry Letters, 2013, Singh, Ravi S.P. et. al.
Design and syntheses of three haptens to generate catalytic antibodies that cleave amide bonds with nucleophilic catalysis
score: 1.6468623, Bioorganic & Medicinal Chemistry, 1999, Ersoy, Oguz et. al.
Extracellular and intracellular esterase processing of SCFA–hexosamine analogs: Implications for metabolic glycoengineering and drug delivery
score: 1.6465569, Bioorganic & Medicinal Chemistry Letters, 2012, Mathew, Mohit P. et. al.
Extracellular and intracellular esterase processing of SCFA–hexosamine analogs: Implications for metabolic glycongineering and drug delivery
score: 1.6465569, Bioorganic & Medicinal Chemistry Letters, 2012, Mathew, Mohit P. et. al.
Extracellular and intracellular esterase processing of SCFA–hexosamine analogs: Implications for metabolic glycoengineering and drug delivery
score: 1.6465569, Bioorganic & Medicinal Chemistry Letters, 2012, Mathew, Mohit P. et. al.
Origin of the stereospecificity in binding hydroxamates of α- and β-phenylalanine methylamide to thermolysin revealed by the X-ray crystallographic study
score: 1.6462501, Bioorganic & Medicinal Chemistry, 2003, Kim, Seung-Jun et. al.
Phosphoramidate derivatives of acyclovir: Synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro
score: 1.6461083, Bioorganic & Medicinal Chemistry, 2012, Zakirova, Natalia F. et. al.
Site-specific incorporation of the 1-hexanol-1, N 6-etheno-2′-deoxyadenosine adduct into oligodeoxyribonucleotides
score: 1.6451376, Bioorganic & Medicinal Chemistry, 2003, Carvalho, Valdemir M et. al.
Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase
score: 1.6449502, Bioorganic & Medicinal Chemistry Letters, 2012, Kashyap, Maneesh et. al.
Novel Azulene Derivatives for the Treatment of Erectile Dysfunction
score: 1.6447063, Bioorganic & Medicinal Chemistry Letters, 2012, Löber, Stefan et. al.
Structural modifications of benzanilide derivatives, effective potassium channel openers. X.
score: 1.6442401, European Journal of Medicinal Chemistry, 2006, Calderone, Vincenzo et. al.
Tris-benzimidazole derivatives: design, synthesis and DNA sequence recognition
score: 1.643692, Bioorganic & Medicinal Chemistry, 2001, Ji, Yu-Hua et. al.
Synthesis and properties of a neutral derivative of diethylenetriaminepentaacetic acid (DTPA)
score: 1.643567, Bioorganic & Medicinal Chemistry Letters, 2006, Peuralahti, Jari et. al.
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities
score: 1.6434573, Bioorganic & Medicinal Chemistry, 2006, Schenone, Silvia et. al.
Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases
score: 1.6433033, Bioorganic & Medicinal Chemistry, 2003, Tossi, Alessandro et. al.
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease
score: 1.6429836, Bioorganic & Medicinal Chemistry Letters, 2012, Al-Baghdadi, Osamah B. et. al.
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease
score: 1.6429836, Bioorganic & Medicinal Chemistry Letters, 2012, Al-Baghdadi, Osamah B. et. al.
Synthesis and functional activity of (2-aryl-1-piperazinyl)- N-(3-methylphenyl)acetamides: selective dopamine D 4 receptor agonists
score: 1.642641, Bioorganic & Medicinal Chemistry, 2004, Matulenko, Mark A et. al.
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C6 position
score: 1.642541, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Sun Ea; Pflum, Mary Kay H.
Indolizine 1-sulfonates as potent inhibitors of 15-lipoxygenase from soybeans
score: 1.6424397, Bioorganic & Medicinal Chemistry, 2005, Teklu, Solomon et. al.
In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.
score: 1.6422786, Antimicrobial agents and chemotherapy, 2005, Falzari, Kanakeshwari et. al.
2D RNA-QSAR: assigning ACC oxidase family membership with stochastic molecular descriptors; isolation and prediction of a sequence from Psidium guajava L
score: 1.6421467, Bioorganic & Medicinal Chemistry Letters, 2005, González-Dı́az, Humberto et. al.
20-Hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction
score: 1.6421437, Bioorganic & Medicinal Chemistry, 2003, Yu, Ming et. al.
Synthesis and cytotoxic activity of N-((2-methyl-4(3 H)-quinazolinon-6-yl)methyl)dithiocarbamates
score: 1.6420955, European Journal of Medicinal Chemistry, 2010, Cao, Sheng-Li et. al.
A TOPological Sub-structural Molecular Design (TOPS-MODE)-QSAR approach for modeling the antiproliferative activity against murine leukemia tumor cell line (L1210)
score: 1.641796, Bioorganic & Medicinal Chemistry, 2009, Molina-Ruiz, Reinaldo et. al.
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides
score: 1.6417636, Bioorganic & Medicinal Chemistry, 2012, Williams, John D. et. al.
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides
score: 1.6417636, Bioorganic & Medicinal Chemistry, 2012, Williams, John D. et. al.
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides
score: 1.6417636, Bioorganic & Medicinal Chemistry, 2012, Williams, John D. et. al.
Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers
score: 1.641742, Bioorganic & Medicinal Chemistry Letters, 2005, Gao, Mingzhang et. al.
Oxovanadium complexes with quinoline and pyridinone ligands: Syntheses of the complexes and effect of alkyl chains on their apoptosis-inducing activity in leukemia cells
score: 1.6414077, Bioorganic & Medicinal Chemistry, 2012, Yamaguchi, Tomoko et. al.
Oxovanadium complexes with quinoline and pyridinone ligands: Syntheses of the complexes and effect of alkyl chains on their apoptosis-inducing activity in leukemia cells
score: 1.6414077, Bioorganic & Medicinal Chemistry, 2012, Yamaguchi, Tomoko et. al.
Synthesis of chromenochalcones and evaluation of their in vitro antileishmanial activity
score: 1.6411914, Bioorganic & Medicinal Chemistry, 2005, Narender, Tadigoppula et. al.
Efficient parallel synthesis of macrocyclic peptidomimetics
score: 1.6409523, Bioorganic & Medicinal Chemistry Letters, 2008, Marsault, Eric et. al.
Synthesis and biological evaluation of new 4β-anilino- and 4β-imido-substituted podophyllotoxin congeners
score: 1.6406508, Bioorganic & Medicinal Chemistry, 2005, Kamal, Ahmed et. al.
QSAR studies about cytotoxicity of benzophenazines with dual inhibition toward both topoisomerases I and II: 3D-MoRSE descriptors and statistical considerations about variable selection
score: 1.6404898, Bioorganic & Medicinal Chemistry, 2006, Saíz-Urra, Liane; González, Maykel Pérez; Teijeira, Marta
Novel trichomonacidal spermicides.
score: 1.6404754, Antimicrobial agents and chemotherapy, 2011, Jain, Ashish et. al.
Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1 H-benzo[ g]indazole-based ligands for cannabinoid receptors
score: 1.6404354, Bioorganic & Medicinal Chemistry, 2005, Murineddu, Gabriele et. al.
Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents
score: 1.6403641, European Journal of Medicinal Chemistry, 2012, Shaaban, Saad et. al.
Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents
score: 1.6403641, European Journal of Medicinal Chemistry, 2012, Shaaban, Saad et. al.
Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5- a]pyrazin-4(5 H)-one derivatives
score: 1.6403192, European Journal of Medicinal Chemistry, 2010, Xie, Yong-Sheng et. al.
The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents
score: 1.6401775, European Journal of Medicinal Chemistry, 2012, Wang, Lei et. al.
Three-dimensional quantitative structure–activity relationship (3D-QSAR) studies of tricyclic oxazolidinones as antibacterial agents
score: 1.6401741, Bioorganic & Medicinal Chemistry, 2003, Gopalakrishnan, Bulusu et. al.
Quaternary ammonium substituted thieno[3,2- e]-1,2-thiazine-6-sulfonamide 1,1-dioxides: Potential membrane-impermeable inhibitors of carbonic anhydrase
score: 1.6401413, Bioorganic & Medicinal Chemistry, 2006, May, Jesse A. et. al.
ER β Ligands. Part 1: The discovery of ER β selective ligands which embrace the 4-hydroxy-biphenyl template
score: 1.6400113, Bioorganic & Medicinal Chemistry, 2003, Edsall, Richard J et. al.
Inhibitory effects of 2-substituted-1-naphthol derivatives on cyclooxygenase I and II
score: 1.6400013, Bioorganic & Medicinal Chemistry, 2005, Kongkathip, Boonsong et. al.
1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for β-adrenoceptor subtypes
score: 1.6399986, Bioorganic & Medicinal Chemistry, 2006, Nikulin, Victor I. et. al.
Small tripeptide surrogates with low nanomolar affinity as potent inhibitors of the botulinum neurotoxin B metallo-proteolytic activity
score: 1.6399461, Bioorganic & Medicinal Chemistry, 2004, Blommaert, Armand et. al.
Exploring three-dimensional quantitative structural activity relationship (3D-QSAR) analysis of SCH 66336 (Sarasar) analogues of farnesyltransferase inhibitors
score: 1.6398309, European Journal of Medicinal Chemistry, 2008, Equbal, Tabish; Silakari, Om; Ravikumar, Muttineni
Combining 3D-QSAR, docking, molecular dynamics and MM/PBSA methods to predict binding modes for nonsteroidal selective modulator to glucocorticoid receptor
score: 1.6395325, Bioorganic & Medicinal Chemistry Letters, 2009, Xu, Yong; Zhang, Tao; Chen, Minbo
2,2-Disubstituted analogues of the natural hormone 1α,25-dihydroxyvitamin D 3: chemistry and biology
score: 1.6393611, Bioorganic & Medicinal Chemistry, 2002, Posner, Gary H. et. al.
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer’s disease
score: 1.6392225, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Yong Dae et. al.
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer’s disease
score: 1.6392225, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Yong Dae et. al.
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer’s disease
score: 1.6392225, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Yong Dae et. al.
Small Molecule Tertiary Amines as Agonists of the Nuclear Hormone Receptor Rev-erbα
score: 1.6390998, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Youseung et. al.
Drug design and synthesis of ε opioid receptor agonist: 17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-7α-( N-methyl- N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative ε opioid receptor
score: 1.6389672, Bioorganic & Medicinal Chemistry, 2004, Fujii, Hideaki et. al.
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential
score: 1.6387906, Bioorganic & Medicinal Chemistry Letters, 2012, Sams, Anette Graven et. al.
N-Hydroxyethyl-piperidine and -pyrrolidine homoazasugars: preparation and evaluation of glycosidase inhibitory activity
score: 1.6387577, Bioorganic & Medicinal Chemistry, 2003, Dhavale, Dilip D et. al.
Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs
score: 1.6387318, European Journal of Medicinal Chemistry, 2006, Crivori, P.; Poggesi, I.
Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker
score: 1.6384888, Bioorganic & Medicinal Chemistry, 2002, Golisade, Abolfasl et. al.
The cruciferous phytoalexins rapalexin A, brussalexin A and erucalexin: chemistry and metabolism in Leptosphaeria maculans
score: 1.6383692, Bioorganic & Medicinal Chemistry, 2012, Pedras, M. Soledade C.; Sarma-Mamillapalle, Vijay K.
Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain
score: 1.6381281, Bioorganic & Medicinal Chemistry Letters, 2012, Adam, Julia M. et. al.
HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.
score: 1.6376014, Antimicrobial agents and chemotherapy, 2012, Vallières, Cindy et. al.
A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores
score: 1.6376012, Bioorganic & Medicinal Chemistry, 2006, Kawasuji, Takashi et. al.
Flexible docking of pyridinone derivatives into the non-nucleoside inhibitor binding site of HIV-1 reverse transcriptase
score: 1.637532, Bioorganic & Medicinal Chemistry, 2004, Medina-Franco, José Luis et. al.
Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions
score: 1.6375191, Bioorganic & Medicinal Chemistry, 2000, Ilies, Monica et. al.
Design, synthesis and biological evaluation of 6-substituted carboxamido benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists
score: 1.6373778, Bioorganic & Medicinal Chemistry, 2012, Zhang, Jun et. al.
Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus.
score: 1.6370102, Antimicrobial agents and chemotherapy, 2002, Krosky, Paula M et. al.
4,5-Diaryl-1 H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents
score: 1.6369889, Bioorganic & Medicinal Chemistry, 2006, Banwell, Martin G. et. al.
Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles
score: 1.636948, Bioorganic & Medicinal Chemistry Letters, 2012, Mandha, Santhosh Reddy et. al.
Antiviral and tumor cell antiproliferative SAR studies on tetracyclic eudistomins—II
score: 1.6367426, Bioorganic & Medicinal Chemistry, 1997, van Maarseveen, Jan H. et. al.
Hexapeptide derivatives of glycopeptide antibiotics: tools for mechanism of action studies.
score: 1.6366337, Antimicrobial agents and chemotherapy, 2002, Allen, Norris E et. al.
Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity
score: 1.6363402, European Journal of Medicinal Chemistry, 2006, Dubinina, G.G. et. al.
Novel non-covalent thrombin inhibitors incorporating P 1 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics
score: 1.6361222, European Journal of Medicinal Chemistry, 2004, Marinko, Petra et. al.
Analogs of the RSK inhibitor SL0101: Optimization of in vitro biological stability
score: 1.6360495, Bioorganic & Medicinal Chemistry Letters, 2012, Hilinski, Michael K. et. al.
Analogs of the RSK inhibitor SL0101: Optimization of in vitro biological stability
score: 1.6360495, Bioorganic & Medicinal Chemistry Letters, 2012, Hilinski, Michael K. et. al.
Analogs of the RSK inhibitor SL0101: Optimization of in vitro biological stability
score: 1.6360495, Bioorganic & Medicinal Chemistry Letters, 2012, Hilinski, Michael K. et. al.
Synthesis of hypermodified adenosine derivatives as selective adenosine A 3 receptor ligands
score: 1.636025, Bioorganic & Medicinal Chemistry, 2006, Cosyn, Liesbet et. al.
Studies on 3′-quaternary ammonium cephalosporins—IV. Synthesis and antibacterial activity of 3′-(2-alkyl-3-aminopyrazolium)cephalosporins related to FK037
score: 1.6359491, Bioorganic & Medicinal Chemistry, 1997, Ohki, Hidenori et. al.
Studies on 3′-quaternary ammonium cephalosporins—IV. Synthesis and antibacterial activity of 3′-(2-alkyl-3-aminopyrazolium)cephalosporins related to FK037
score: 1.6359491, Bioorganic & Medicinal Chemistry, 1997, Ohki, Hidenori et. al.
Microwave-assisted one step synthesis of 8-arylmethyl-9 H-purin-6-amines
score: 1.6358582, Bioorganic & Medicinal Chemistry Letters, 2009, Tao, Hui; Kang, Yanlong; Taldone, Tony; Chiosis, Gabriela
Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors
score: 1.6357191, Bioorganic & Medicinal Chemistry, 2006, Farhanullah, et. al.
Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine
score: 1.635656, Bioorganic & Medicinal Chemistry Letters, 2004, Chang, Yusuo et. al.
Makomotindoline from Makomotake, Zizania latifolia Infected with Ustilago esculenta
score: 1.6355589, Bioorganic & Medicinal Chemistry Letters, 2012, Suzuki, Tomohiro et. al.
Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide
score: 1.6353637, Bioorganic & Medicinal Chemistry, 2006, Kotoku, Naoyuki et. al.
Identification of a selective small molecule inhibitor of breast cancer stem cells
score: 1.6353482, Bioorganic & Medicinal Chemistry Letters, 2012, Germain, Andrew R. et. al.
Identification of a selective small molecule inhibitor of breast cancer stem cells
score: 1.6353482, Bioorganic & Medicinal Chemistry Letters, 2012, Germain, Andrew R. et. al.
Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors
score: 1.6352583, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors
score: 1.6352583, Bioorganic & Medicinal Chemistry Letters, 2012, Kamata, Makoto et. al.
In vitro biological evaluation of platinum(II) complexes with 1-(methoxy substituted benzyl) azetidine-3,3-dicarboxylato ligands
score: 1.6351903, Bioorganic & Medicinal Chemistry, 2012, Yin, Runting; Gou, Shaohua; Sun, Yanyan; Liu, Xia
Thio-derived disulfides as potent inhibitors of botulinum neurotoxin type B: implications for zinc interaction
score: 1.635155, Bioorganic & Medicinal Chemistry, 2003, Anne, Christine et. al.
Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity
score: 1.6350861, Bioorganic & Medicinal Chemistry, 2004, Koshio, Hiroyuki et. al.
Analysis of stereoelectronic properties of camptothecin analogues in relation to biological activity
score: 1.6349496, Bioorganic & Medicinal Chemistry, 2000, Werbovetz, Karl A. et. al.
A bicyclic and hsst2 selective somatostatin analogue: design, synthesis, conformational analysis and binding
score: 1.6348826, Bioorganic & Medicinal Chemistry, 2001, Falb, Eliezer et. al.
Enantiomerical excess determination, purification and biological evaluation of (3 S) and (3 R) α,β-butenolide analogues of isobenzofuranone
score: 1.6347589, Bioorganic & Medicinal Chemistry Letters, 2005, Lipka, Emmanuelle et. al.
Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone
score: 1.6346049, Bioorganic & Medicinal Chemistry Letters, 2012, Simpkins, Nigel S. et. al.
Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides
score: 1.6345906, European Journal of Medicinal Chemistry, 2013, Liang, Jian-Hua et. al.
Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides
score: 1.6345906, European Journal of Medicinal Chemistry, 2013, Liang, Jian-Hua et. al.
Synthesis and cytotoxicity of 4′- C- and 5′- C-substituted toyocamycins
score: 1.6345181, Bioorganic & Medicinal Chemistry, 2001, Gunic, Esmir et. al.
Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis, antitumor evaluation, and DNA photocleavage
score: 1.6345043, Bioorganic & Medicinal Chemistry, 2005, Li, Zhigang; Yang, Qing; Qian, Xuhong
Synthesis and pharmacological properties of benzamide derivatives as selective serotonin 4 receptor agonists
score: 1.6343649, Bioorganic & Medicinal Chemistry, 2004, Sonda, Shuji et. al.
Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase.
score: 1.6343458, Antimicrobial agents and chemotherapy, 2001, Kati, W M et. al.
A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs
score: 1.6343296, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang
A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs
score: 1.6343296, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang
Synthesis and antitumor activity of formononetin nitrogen mustard derivatives
score: 1.6343172, European Journal of Medicinal Chemistry, 2012, Ren, Jie et. al.
Synthesis and antitumor activity of formononetin nitrogen mustard derivatives
score: 1.6343172, European Journal of Medicinal Chemistry, 2012, Ren, Jie et. al.
Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine
score: 1.6341893, Bioorganic & Medicinal Chemistry Letters, 2004, Pineda, Oriol et. al.
Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor
score: 1.6341273, Bioorganic & Medicinal Chemistry, 1999, Vara Prasad, J.V.N. et. al.
Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol
score: 1.634105, Bioorganic & Medicinal Chemistry Letters, 2009, Calderón, Marcelo et. al.
Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil
score: 1.6338192, Bioorganic & Medicinal Chemistry Letters, 2000, Baxendale, Ian R; Ley, Steven V
Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents
score: 1.6337793, Bioorganic & Medicinal Chemistry, 2012, Zhang, Hui et. al.
Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents
score: 1.6337793, Bioorganic & Medicinal Chemistry, 2012, Zhang, Hui et. al.
Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents
score: 1.6337793, Bioorganic & Medicinal Chemistry, 2012, Zhang, Hui et. al.
Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.6337071, European Journal of Medicinal Chemistry, 2012, Wang, Xiao-Liang et. al.
Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
score: 1.6337071, European Journal of Medicinal Chemistry, 2012, Wang, Xiao-Liang et. al.
Expression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a
score: 1.6336911, Bioorganic & Medicinal Chemistry Letters, 2010, Lu, Jing-Ping; Ye, Qi-Zhuang
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux
score: 1.633611, Bioorganic & Medicinal Chemistry Letters, 2012, Kuriakose, Jerrin; Hrycyna, Christine A.; Chmielewski, Jean
Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
score: 1.6334975, Antimicrobial agents and chemotherapy, 2011, Berke, Jan Martin et. al.
Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization.
score: 1.6333177, Antimicrobial agents and chemotherapy, 2011, Sandlin, Rebecca D et. al.
The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase
score: 1.6330778, Bioorganic & Medicinal Chemistry, 2006, Li, Hui-Yuan et. al.
QSAR study of mosquito repellents using Codessa Pro
score: 1.6329836, Bioorganic & Medicinal Chemistry Letters, 2006, Katritzky, Alan R. et. al.
Structure–activity relationship studies on chalcone derivatives
score: 1.6329266, Bioorganic & Medicinal Chemistry, 2003, Ko, Horng-Huey et. al.
Tricyclic oxazolo[2,3- f]purinediones: potency as adenosine receptor ligands and anticonvulsants
score: 1.6328821, Bioorganic & Medicinal Chemistry, 2004, Drabczyńska, Anna et. al.
Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase
score: 1.6327342, Bioorganic & Medicinal Chemistry, 1997, Njoroge, F.George et. al.
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012
score: 1.6325625, Bioorganic & Medicinal Chemistry Letters, 2012, Melancon, Bruce J. et. al.
A laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity
score: 1.632478, Bioorganic & Medicinal Chemistry, 2012, Wellington, Kevin W.; Kolesnikova, Natasha I.
A laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity
score: 1.632478, Bioorganic & Medicinal Chemistry, 2012, Wellington, Kevin W.; Kolesnikova, Natasha I.
A laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity
score: 1.632478, Bioorganic & Medicinal Chemistry, 2012, Wellington, Kevin W.; Kolesnikova, Natasha I.
Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines
score: 1.632103, European Journal of Medicinal Chemistry, 2009, Doláková, Petra et. al.
Radiolytic one-electron reduction characteristics of tyrosine derivative caged by 2-oxopropyl group
score: 1.6320424, Bioorganic & Medicinal Chemistry Letters, 2008, Tanabe, Kazuhito et. al.
Hydrophobicity: is LogP o/w more than the sum of its parts?
score: 1.6318337, European Journal of Medicinal Chemistry, 2000, Eugene Kellogg, Glen; Abraham, Donald J.
Probing for a hydrophobic a binding register in prostate-specific membrane antigen with phenylalkylphosphonamidates
score: 1.631809, Bioorganic & Medicinal Chemistry, 2004, Maung, Jack et. al.
Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors
score: 1.631805, Bioorganic & Medicinal Chemistry, 1999, Legraverend, Michel et. al.
Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani
score: 1.6317775, Bioorganic & Medicinal Chemistry Letters, 2012, Gohil, Vikrantsinh M. et. al.
Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani
score: 1.6317775, Bioorganic & Medicinal Chemistry Letters, 2012, Gohil, Vikrantsinh M. et. al.
Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani
score: 1.6317775, Bioorganic & Medicinal Chemistry Letters, 2012, Gohil, Vikrantsinh M. et. al.
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
score: 1.6316953, Nature chemical biology, 2012, Georghiou, George et. al.
N-Nitrosoanilines: a new class of caspase-3 inhibitors
score: 1.631331, Bioorganic & Medicinal Chemistry, 2001, Guo, Zhengmao et. al.
Triazoyl–phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside
score: 1.6311356, Bioorganic & Medicinal Chemistry Letters, 2013, Tamura, Satoru et. al.
Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-chloro imidazole embodied 4-azafluorenones via molecular hybridization approach
score: 1.6310723, Bioorganic & Medicinal Chemistry Letters, 2012, Addla, Dinesh et. al.
Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase
score: 1.6310403, Bioorganic & Medicinal Chemistry Letters, 2012, Hartsel, Joshua A. et. al.
Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase
score: 1.6310403, Bioorganic & Medicinal Chemistry Letters, 2012, Hartsel, Joshua A. et. al.
Development of new simple molecular probes of DNA bulged structures
score: 1.6310029, Bioorganic & Medicinal Chemistry Letters, 2006, Xiao, Ziwei; Kappen, Lizzy S.; Goldberg, Irving H.
Efficient synthesis of C-terminal modified peptide ketones for chemical ligations
score: 1.6308777, Bioorganic & Medicinal Chemistry Letters, 2005, Marceau, Philippe; Buré, Corinne; Delmas, Agnès F.
Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers
score: 1.6307615, European Journal of Medicinal Chemistry, 2013, Tseng, Chih-Hua et. al.
Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers
score: 1.6307615, European Journal of Medicinal Chemistry, 2013, Tseng, Chih-Hua et. al.
Non-Thiol farnesyltransferase inhibitors: utilization of an aryl binding site by 5-arylacryloylaminobenzophenones
score: 1.6307211, Bioorganic & Medicinal Chemistry, 2002, Mitsch, Andreas et. al.
Synthesis and cytotoxicity study of alkannin derivatives
score: 1.6303127, European Journal of Medicinal Chemistry, 2004, Huang, Zhi-Shu et. al.
Studies of inclusion complexes of natural and modified cyclodextrin with (+)catechin by NMR and molecular modeling
score: 1.6302239, Bioorganic & Medicinal Chemistry, 2007, Jullian, Carolina et. al.
Design and synthesis of prodrugs of the rat selective toxicant norbormide
score: 1.6302204, Bioorganic & Medicinal Chemistry, 2012, Rennison, David et. al.
Design and synthesis of prodrugs of the rat selective toxicant norbormide
score: 1.6302204, Bioorganic & Medicinal Chemistry, 2012, Rennison, David et. al.
Design and synthesis of prodrugs of the rat selective toxicant norbormide
score: 1.6302204, Bioorganic & Medicinal Chemistry, 2012, Rennison, David et. al.
Structure–activity relationship analysis of N-benzoylpyrazoles for elastase inhibitory activity: A simplified approach using atom pair descriptors
score: 1.6299812, Bioorganic & Medicinal Chemistry, 2008, Khlebnikov, Andrei I.; Schepetkin, Igor A.; Quinn, Mark T.
Synthesis and characterization of pyruvate–isoniazid analogs and their copper complexes as potential ICL inhibitors
score: 1.6299112, Bioorganic & Medicinal Chemistry Letters, 2012, Shingnapurkar, Dipti et. al.
Synthesis and characterization of pyruvate–isoniazid analogs and their copper complexes as potential ICL inhibitors
score: 1.6299112, Bioorganic & Medicinal Chemistry Letters, 2012, Shingnapurkar, Dipti et. al.
Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules.
score: 1.6298167, Antimicrobial agents and chemotherapy, 2003, Givens, M Daniel et. al.
2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors
score: 1.6296833, Bioorganic & Medicinal Chemistry, 2003, Sakamuri, Sukumar et. al.
Synthesis, biological evaluation, and molecular docking studies of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)aniline derivatives as novel anticancer agents
score: 1.629672, Bioorganic & Medicinal Chemistry, 2012, Huang, Xian-Feng et. al.
Development of small-molecule P-gp inhibitors of the N-benzyl 1,4-dihydropyridine type: Novel aspects in SAR and bioanalytical evaluation of multidrug resistance (MDR) reversal properties
score: 1.6295447, Bioorganic & Medicinal Chemistry, 2013, Baumert, Christiane et. al.
Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activity
score: 1.6295248, Bioorganic & Medicinal Chemistry Letters, 2012, Min, Byung Sun et. al.
Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activity
score: 1.6295248, Bioorganic & Medicinal Chemistry Letters, 2012, Min, Byung Sun et. al.
Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activity
score: 1.6295248, Bioorganic & Medicinal Chemistry Letters, 2012, Min, Byung Sun et. al.
Selectivity determinants of inhibitor binding to the tumour marker human aldose reductase-like protein (AKR1B10) discovered from molecular docking and database screening
score: 1.6292681, European Journal of Medicinal Chemistry, 2010, Zhao, Hai-Tao et. al.
Synthesis and one-electron reduction characteristics of radiation-activated prodrugs possessing two 5-fluorodeoxyuridine units
score: 1.6291343, Bioorganic & Medicinal Chemistry, 2012, Tanabe, Kazuhito et. al.
The cruciferous phytoalexins rapalexin A, brussalexin A and erucalexin: Chemistry and metabolism in Leptosphaeria maculans
score: 1.6291147, Bioorganic & Medicinal Chemistry, 2012, Pedras, M. Soledade C.; Sarma-Mamillapalle, Vijay K.
The cruciferous phytoalexins rapalexin A, brussalexin A and erucalexin: Chemistry and metabolism in Leptosphaeria maculans
score: 1.6291147, Bioorganic & Medicinal Chemistry, 2012, Pedras, M. Soledade C.; Sarma-Mamillapalle, Vijay K.
Correlation of the acid-sensitivity of polyethylene glycol daunorubicin conjugates with their in vitro antiproliferative activity
score: 1.6289012, Bioorganic & Medicinal Chemistry, 2006, Rodrigues, Paula C.A. et. al.
Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of π*–π* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT 1 non-peptide antagonists
score: 1.6288663, Bioorganic & Medicinal Chemistry, 2001, Polevaya, Ludmila et. al.
Synthesis and pharmacological evaluation of N-acyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents
score: 1.6288035, Bioorganic & Medicinal Chemistry, 2004, Kubota, Hideki et. al.
Non-enzymatic reduction of a 1,2,4-thiadiazolium derivative
score: 1.6287125, Bioorganic & Medicinal Chemistry Letters, 2008, Zhang, Fa; Estavillo, Carmelita; Mohler, Margie; Cai, Jane
Synthesis and biological evaluation of 2,8-disubstituted 9-benzyladenines: discovery of 8-mercaptoadenines as potent interferon-inducers
score: 1.6286677, Bioorganic & Medicinal Chemistry, 2003, Hirota, Kosaku; Kazaoka, Kazunori; Sajiki, Hironao
Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity
score: 1.6283444, European Journal of Medicinal Chemistry, 2012, Skiba, Joanna et. al.
Synthesis of ( R, S)-[4- 11C]baclofen via Michael addition of nitromethane labeled with short-lived 11C
score: 1.6281431, Bioorganic & Medicinal Chemistry Letters, 2009, Kato, Koichi; Zhang, Ming-Rong; Suzuki, Kazutoshi
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease
score: 1.6278842, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Yun Suk et. al.
In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems with potent activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
score: 1.627813, Antimicrobial agents and chemotherapy, 2000, Nagano, R et. al.
Dehydroabietic acid derivatives as a novel scaffold for large-Conductance calcium-Activated K + channel openers
score: 1.6277885, Bioorganic & Medicinal Chemistry Letters, 2003, Ohwada, Tomohiko et. al.
Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: Synthesis, SAR and biological evaluation
score: 1.6275506, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Heung Jae et. al.
Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna
score: 1.6275182, Bioorganic & Medicinal Chemistry, 2012, Li, Jing; van Belkum, Marco J.; Vederas, John C.
Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna
score: 1.6275182, Bioorganic & Medicinal Chemistry, 2012, Li, Jing; van Belkum, Marco J.; Vederas, John C.
Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna
score: 1.6275182, Bioorganic & Medicinal Chemistry, 2012, Li, Jing; van Belkum, Marco J.; Vederas, John C.
Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna
score: 1.6275182, Bioorganic & Medicinal Chemistry, 2012, Li, Jing; van Belkum, Marco J.; Vederas, John C.
Design, Synthesis, Conformational Analysis, and Biological Studies of Urotensin-II Lactam Analogues
score: 1.6273944, Bioorganic & Medicinal Chemistry, 2002, Grieco, Paolo et. al.
Synthesis of docosahexaenoic acid derivatives designed as novel PPARγ agonists and antidiabetic agents
score: 1.6273715, Bioorganic & Medicinal Chemistry, 2006, Itoh, Toshimasa et. al.
Preparation of crystalline p-nitrobenzyl 2-formyl carbapenems by oxidative cleavage
score: 1.626816, Bioorganic & Medicinal Chemistry Letters, 1999, Hsiao, Yi et. al.
The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide
score: 1.6267447, Bioorganic & Medicinal Chemistry Letters, 2005, Blanchfield, Joanne T. et. al.
Synthesis, Characterization, Molecular Docking and Cytotoxic Activity of Novel Plumbagin Hydrazones against Breast Cancer Cells
score: 1.6265738, Bioorganic & Medicinal Chemistry Letters, 2012, Dandawate, Prasad et. al.
Prodrug strategies in cancer therapy
score: 1.6263961, European Journal of Medicinal Chemistry, 2001, Denny, William A
Isoxazole-based derivatives from Baylis–Hillman chemistry: assessment of preliminary hypolipidemic activity
score: 1.6262708, Bioorganic & Medicinal Chemistry, 2003, Patra, A et. al.
Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold
score: 1.6260377, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tiehai et. al.
Remarkable tethering effect on DNA cleavage of propargylic sulfone conjugates with intercalating moieties
score: 1.6259887, Bioorganic & Medicinal Chemistry Letters, 1998, Wei-Min Dai, et. al.
The rationale for E2020 as a potent acetylcholinesterase inhibitor
score: 1.6258991, Bioorganic & Medicinal Chemistry, 1996, Kawakami, Yoshiyuki et. al.
Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues
score: 1.6257102, Bioorganic & Medicinal Chemistry, 2005, Guillonneau, Claude et. al.
Biological activities of retinoidal γ-hydroxybutenolides in cancer cell apoptosis and differentiation
score: 1.6256724, Bioorganic & Medicinal Chemistry, 2005, Yamano, Yumiko et. al.
Process R&D under the magnifying glass: Organization, business model, challenges, and scientific context
score: 1.6254565, Bioorganic & Medicinal Chemistry, 2010, Federsel, Hans-Jürgen
Investigation of 7-benzylidenenaltrexone derivatives as resistance reverser for chloroquine-resistant Plasmodium chabaudi
score: 1.6253932, Bioorganic & Medicinal Chemistry Letters, 2012, Miyata, Yoshinori et. al.
Docking studies and development of novel 5-heteroarylamino-2,4-diamino-8-chloropyrimido-[4,5- b]quinolines as potential antimalarials
score: 1.6253212, Bioorganic & Medicinal Chemistry Letters, 2006, Joshi, Advait A.; Viswanathan, C.L.
Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives
score: 1.6252526, Bioorganic & Medicinal Chemistry Letters, 2012, Lavrado, João et. al.
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase
score: 1.6252256, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Jiae et. al.
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase
score: 1.6252256, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Jiae et. al.
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase
score: 1.6252256, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Jiae et. al.
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1)
score: 1.625153, Bioorganic & Medicinal Chemistry, 2012, Mayhoub, Abdelrahman S. et. al.
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1)
score: 1.625153, Bioorganic & Medicinal Chemistry, 2012, Mayhoub, Abdelrahman S. et. al.
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1)
score: 1.625153, Bioorganic & Medicinal Chemistry, 2012, Mayhoub, Abdelrahman S. et. al.
HIV protease inhibitors: synthesis and activity of N-aryl- N′-hydroxyalkyl hydrazide pseudopeptides
score: 1.6250445, European Journal of Medicinal Chemistry, 2005, Marastoni, M. et. al.
Structure–activity relationship of HIV-1 protease inhibitors containing α-hydroxy-β-amino acids. Detailed study of P 1 site
score: 1.6250164, Bioorganic & Medicinal Chemistry, 1999, Takashiro, Eiji et. al.
Design of multifunctional peptides expressing both antimicrobial activity and shiga toxin neutralization activity
score: 1.6249234, Bioorganic & Medicinal Chemistry, 2006, Yamada, Yoshinao et. al.
Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity.
score: 1.6248681, Antimicrobial agents and chemotherapy, 2003, Uckun, Fatih M et. al.
Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors
score: 1.6246674, Bioorganic & Medicinal Chemistry Letters, 2004, Jeong, Tae-Sook et. al.
Understanding the structure–activity and structure–selectivity correlation of cyclic guanine derivatives as phosphodiesterase-5 inhibitors by molecular docking, CoMFA and CoMSIA analyses
score: 1.624478, Bioorganic & Medicinal Chemistry, 2006, Yang, Guang-Fu; Lu, Hai-Ting; Xiong, Ying; Zhan, Chang-Guo
The Privileged Chemical Space Predictor ( pcsp): A computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries
score: 1.6244403, Bioorganic & Medicinal Chemistry Letters, 2010, Seedhouse, Steven J.; Labuda, Lucas P.; Disney, Matthew D.
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold
score: 1.6243935, European Journal of Medicinal Chemistry, 2012, Manera, Clementina et. al.
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold
score: 1.6243935, European Journal of Medicinal Chemistry, 2012, Manera, Clementina et. al.
Bio-inspired synthesis and biological evaluation of a colchicine-related compound library
score: 1.6242979, Bioorganic & Medicinal Chemistry Letters, 2012, Nicolaou, K.C. et. al.
A C-Ring Regioisomer of the Marine Alkaloid Meridine Exhibits Selective In Vitro Cytotoxicity for Solid Tumours
score: 1.6242431, Bioorganic & Medicinal Chemistry, 2001, Ángel de la Fuente, Jesús et. al.
The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages
score: 1.6241192, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jin-Hui; Lan, Xiang-Peng; Liu, Yonghong; Jia, Ai-Qun
The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages
score: 1.6241192, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jin-Hui; Lan, Xiang-Peng; Liu, Yonghong; Jia, Ai-Qun
Synthesis and antimalarial activity of 6-cycloalkylvinyl substituted 1,2,4-trioxanes
score: 1.6240797, Bioorganic & Medicinal Chemistry, 2004, Singh, Chandan; Srivastav, Naveen Chandra; Puri, Sunil K.
Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)
score: 1.624074, Bioorganic & Medicinal Chemistry Letters, 2012, Leurs, Ulrike et. al.
Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
score: 1.6239023, Bioorganic & Medicinal Chemistry Letters, 2001, Suhara, Yoshitomo et. al.
Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents
score: 1.6238373, European Journal of Medicinal Chemistry, 2012, Bengtsson, Christoffer et. al.
Structure-activity studies of fluoroaljyl-substituted γ-butyrolactone and γ-thiobutyrolactone modulators of GABA A receptor function
score: 1.6237744, Bioorganic & Medicinal Chemistry, 1998, Canney, Daniel J. et. al.
Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents
score: 1.6236443, Bioorganic & Medicinal Chemistry Letters, 2012, Dulla, Balakrishna et. al.
Antimalarial and antiproliferative evaluation of Bis-Steroidal tetraoxanes
score: 1.6235368, Bioorganic & Medicinal Chemistry, 2003, Opsenica, Dejan et. al.
In vitro activities of new 2-substituted quinolines against Leishmania donovani.
score: 1.6231381, Antimicrobial agents and chemotherapy, 2011, Loiseau, Philippe M et. al.
Design, synthesis, and inhibition of platelet aggregation for some 1- o-chlorophenyl-1,2,3,4-tetrahydroisoquinoline derivatives
score: 1.6231292, Bioorganic & Medicinal Chemistry, 2004, Yang, Jie et. al.
Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure–activity relationships and nitric oxide release
score: 1.6230251, Bioorganic & Medicinal Chemistry, 2005, Nguyen, Jeffrey-Tri; Velázquez, Carlos A.; Knaus, Edward E.
Potent and selective cathepsin K inhibitors
score: 1.6229126, Bioorganic & Medicinal Chemistry, 2006, Shinozuka, Tsuyoshi et. al.
The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors
score: 1.622783, Bioorganic & Medicinal Chemistry, 2005, Cody, Wayne L. et. al.
Purpuroines A-J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases
score: 1.6225621, Bioorganic & Medicinal Chemistry, 2012, Shen, Shi; Liu, Dong; Wei, Chen; Proksch, Peter; Lin, Wenhan
Search for dual function inhibitors for Alzheimer’s disease: Synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Aβ fibril formation inhibition capacity
score: 1.6224165, Bioorganic & Medicinal Chemistry, 2006, Kapková, Petra et. al.
Substrate variants versus transition state analogues as noncovalent reversible enzyme inhibitors
score: 1.622245, Bioorganic & Medicinal Chemistry, 2004, Smyth, Timothy P
Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines
score: 1.6221959, European Journal of Medicinal Chemistry, 2012, Ihmaid, Saleh K. et. al.
Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines
score: 1.6221959, European Journal of Medicinal Chemistry, 2012, Ihmaid, Saleh K. et. al.
First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104
score: 1.6220938, Bioorganic & Medicinal Chemistry Letters, 1999, Suzuki, Mikio et. al.
Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α–p300 interaction by a small molecule
score: 1.6220172, Bioorganic & Medicinal Chemistry Letters, 2012, Kwon, Hyuk Sung et. al.
Synthesis and receptor binding studies of halogenated N, N-dialkylel-(2-phenyl-1 H-indol-3-yl)glyoxylamides to visualize peripheral benzodiazepine receptors with SPECT or PET
score: 1.6215325, Bioorganic & Medicinal Chemistry, 2006, Bennacef, Idriss et. al.
Synthesis and biological characterization of novel hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors
score: 1.6212093, Bioorganic & Medicinal Chemistry, 2004, Dutta, Aloke K et. al.
Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2 H-thiazolo [4,5- d] pyrimidine derivatives as adenosine A 2A receptor antagonists
score: 1.6211907, Bioorganic & Medicinal Chemistry Letters, 2010, Luthra, Pratibha Mehta et. al.
The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents
score: 1.6209163, European Journal of Medicinal Chemistry, 2012, Wang, Lei et. al.
Inhibition of the HIV-1 rev–RRE complex formation by unfused aromatic cations
score: 1.6207431, Bioorganic & Medicinal Chemistry, 2001, Xiao, Ge et. al.
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity
score: 1.6204507, Bioorganic & Medicinal Chemistry, 2005, Escuret, Vanessa et. al.
Synthesis and application of an auxiliary group for chemical ligation at the X-gly site
score: 1.6202515, Bioorganic & Medicinal Chemistry Letters, 2002, Vizzavona, Jean; Dick, Fritz; Vorherr, Thomas
Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10-undecenoic acid hydrazide
score: 1.62025, European Journal of Medicinal Chemistry, 2005, Rahman, V.P. Mujeebur et. al.
Synthesis, structure and quantitative structure-activity relationships of σ receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines
score: 1.6197976, Bioorganic & Medicinal Chemistry, 1997, Fujimura, Ken-ichi et. al.
Synthesis, structure and quantitative structure-activity relationships of σ receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines
score: 1.6197976, Bioorganic & Medicinal Chemistry, 1997, Fujimura, Ken-ichi et. al.
Structural basis for selective inhibition of COX-2 by nimesulide
score: 1.6197332, Bioorganic & Medicinal Chemistry, 1998, Fabiola, Gabriel F. et. al.
Identification of small-molecule inhibitors of nucleoside triphosphate hydrolase in Toxoplasma gondii.
score: 1.6193364, Antimicrobial agents and chemotherapy, 2002, Asai, Takashi et. al.
Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4 H-pyrrolo[3,2,1- ij]quinolin-4-one (TAK-802) and related compounds
score: 1.6191052, Bioorganic & Medicinal Chemistry, 2005, Ishichi, Yuji et. al.
Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors
score: 1.6188834, European Journal of Medicinal Chemistry, 2012, Loidreau, Yvonnick et. al.
5- N-Substituted-2-(substituted benzenesulphonyl) glutamines as antitumor agents. Part II: Synthesis, biological activity and QSAR study
score: 1.6186751, Bioorganic & Medicinal Chemistry, 2004, Samanta, Soma et. al.
Alkyl and alkoxycarbonyl derivatives of ginkgolide B
score: 1.6185074, Bioorganic & Medicinal Chemistry, 2000, Hu, Lihong et. al.
Efficient synthesis of fluorothiosparfosic acid analogues with potential antitumoral activity
score: 1.6184933, Bioorganic & Medicinal Chemistry, 2005, Pfund, Emmanuel et. al.
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors
score: 1.6184517, Bioorganic & Medicinal Chemistry Letters, 2012, Cheung, Adrian Wai-Hing et. al.
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors
score: 1.6184517, Bioorganic & Medicinal Chemistry Letters, 2012, Cheung, Adrian Wai-Hing et. al.
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors
score: 1.6184517, Bioorganic & Medicinal Chemistry Letters, 2012, Cheung, Adrian Wai-Hing et. al.
Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor
score: 1.618335, Bioorganic & Medicinal Chemistry, 2012, Komiya, Masafumi et. al.
Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor
score: 1.618335, Bioorganic & Medicinal Chemistry, 2012, Komiya, Masafumi et. al.
Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor
score: 1.618335, Bioorganic & Medicinal Chemistry, 2012, Komiya, Masafumi et. al.
Synthesis and biological evaluation of 9-(5′,5′-difluoro-5′-phosphonopentyl)guanine derivatives for PNP-inhibitors
score: 1.6183338, Bioorganic & Medicinal Chemistry, 2006, Hikishima, Sadao et. al.
Physicochemical property profiles of marketed drugs, clinical candidates and bioactive compounds
score: 1.6183144, Bioorganic & Medicinal Chemistry Letters, 2009, Tyrchan, Christian et. al.
Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1′-biphenyl]-4-ylethyl) analogues of 8-CAC
score: 1.618196, Bioorganic & Medicinal Chemistry Letters, 2012, Wentland, Mark P. et. al.
Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1′-biphenyl]-4-ylethyl) analogues of 8-CAC
score: 1.618196, Bioorganic & Medicinal Chemistry Letters, 2012, Wentland, Mark P. et. al.
Synthesis and evaluation of bifunctional chelating agents derived from bis(2-aminophenylthio)alkane for radioimaging with 99mTc
score: 1.6180337, Bioorganic & Medicinal Chemistry, 2005, Chhikara, Bhupender S. et. al.
1,5-Benzodiazepines. Part XII. Synthesis and biological evaluation of tricyclic and tetracyclic 1,5-benzodiazepine derivatives as nevirapine analogues
score: 1.6179925, European Journal of Medicinal Chemistry, 2001, Di Braccio, Mario et. al.
CP-MLR directed QSAR studies on the antimycobacterial activity of functionalized alkenols—topological descriptors in modeling the activity
score: 1.6179805, Bioorganic & Medicinal Chemistry, 2005, Gupta, Manish K. et. al.
Antioxidant and anticancer activities of novel p-alkylaminophenols and p-acylaminophenols (aminophenol analogues)
score: 1.6179225, Bioorganic & Medicinal Chemistry, 2006, Takahashi, Noriko et. al.
The discovery of BMS-275183: an orally efficacious novel taxane
score: 1.6178354, Bioorganic & Medicinal Chemistry, 2003, Mastalerz, Harold et. al.
Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework
score: 1.6177594, Bioorganic & Medicinal Chemistry, 2008, Källström, Sara; Leino, Reko
Design and synthesis of thrombin receptor-derived nonpeptide mimetics utilizing a piperazine scaffold
score: 1.6175788, Bioorganic & Medicinal Chemistry, 1999, Alexopoulos, Kostas et. al.
Synthesis and QSAR Studies of 4-Substituted phenyl-2,6-dimethyl-3, 5-bis- N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents
score: 1.6174847, Bioorganic & Medicinal Chemistry, 2001, Desai, Bhavik et. al.
Semisynthesis and biological activity of aminoacyl triesters of squamocin, an annonaceous acetogenin
score: 1.6174235, Bioorganic & Medicinal Chemistry, 2005, Duval, Romain A. et. al.
Synthesis, antimicrobial evaluation and QSAR studies of novel piperidin-4-yl-5-spiro-thiadiazoline derivatives
score: 1.6173625, Bioorganic & Medicinal Chemistry Letters, 2010, Umamatheswari, Seeman et. al.
Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates
score: 1.6164453, Bioorganic & Medicinal Chemistry Letters, 2012, Dudkin, Vadim Y. et. al.
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists
score: 1.6160367, Bioorganic & Medicinal Chemistry Letters, 2012, Besidski, Yevgeni et. al.
Synthesis and Structure-Activity Relationship Studies of Cytotoxic Vinorelbine Amide Analogues
score: 1.6158798, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Lingjun et. al.
Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease
score: 1.6158167, Bioorganic & Medicinal Chemistry Letters, 2012, Christopher Sheng, X. et. al.
Syntheses of 1,2-annulated and 1-spiroannulated carbohydrate derivatives: Recent developments
score: 1.6157854, Bioorganic & Medicinal Chemistry, 2012, Awan, Shahid I.; Werz, Daniel B.
Synthesis and in vitro evaluation of [18F](R)-FEPAQ: A potential PET ligand for VEGFR2
score: 1.6153361, Bioorganic & Medicinal Chemistry Letters, 2012, Prabhakaran, Jaya et. al.
Activity landscape modeling of PPAR ligands with dual-activity difference maps
score: 1.6153004, Bioorganic & Medicinal Chemistry, 2012, Méndez-Lucio, Oscar et. al.
Activity landscape modeling of PPAR ligands with dual-activity difference maps
score: 1.6153004, Bioorganic & Medicinal Chemistry, 2012, Méndez-Lucio, Oscar et. al.
Activity landscape modeling of PPAR ligands with dual-activity difference maps
score: 1.6153004, Bioorganic & Medicinal Chemistry, 2012, Méndez-Lucio, Oscar et. al.
Preparation and biological activity of 13-substituted retinoic acids
score: 1.6150315, Bioorganic & Medicinal Chemistry, 2004, Wada, Akimori et. al.
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
score: 1.6146225, Bioorganic & Medicinal Chemistry Letters, 2012, Tanis, Virginia M. et. al.
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
score: 1.6146225, Bioorganic & Medicinal Chemistry Letters, 2012, Tanis, Virginia M. et. al.
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
score: 1.6146225, Bioorganic & Medicinal Chemistry Letters, 2012, Tanis, Virginia M. et. al.
3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists
score: 1.6145371, Bioorganic & Medicinal Chemistry Letters, 2005, Neel, David A. et. al.
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid
score: 1.6144448, Bioorganic & Medicinal Chemistry Letters, 2005, Cynkowska, Grazyna et. al.
Synthesis and biological activity of conformationally restricted gypsy moth pheromone mimics
score: 1.6140912, Bioorganic & Medicinal Chemistry, 2010, Chen, Hao; Gong, Yongmei; Gries, Regine M.; Plettner, Erika
Spiro-annulation of barbituric acid derivatives and its analogs by ring-closing metathesis reaction
score: 1.6139728, Bioorganic & Medicinal Chemistry Letters, 2005, Kotha, Sambasivarao et. al.
Ring-substituted imidazoles as a new class of anti-tuberculosis agents
score: 1.6136527, European Journal of Medicinal Chemistry, 2004, Gupta, Preeti; Hameed, Shahul; Jain, Rahul
Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors
score: 1.6136162, Bioorganic & Medicinal Chemistry, 1999, Olson, Jed E et. al.
Synthesis of 2-(5-Bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1 H-pyrrole analogues and their binding affinities for dopamine D 2, D 3, and D 4 receptors
score: 1.6135847, Bioorganic & Medicinal Chemistry, 2003, Mach, Robert H et. al.
Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule Hypoxia Inducible Factor-1 (HIF-1) pathway inhibitor and anti-cancer agent
score: 1.6134359, Bioorganic & Medicinal Chemistry, 2012, Mun, Jiyoung et. al.
Construction of sequence-selective peptide receptors from conformationally restricted eta- and theta- amino acids
score: 1.613141, Bioorganic & Medicinal Chemistry Letters, 1999, Ryan, Kevin; Still, W.Clark
Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents
score: 1.613059, European Journal of Medicinal Chemistry, 2012, Rizk, Ola H.; Shaaban, Omaima G.; El-Ashmawy, Ibrahim M.
Synthesis and in vitro evaluation of [18F](R)-FEPAQ: A potential PET ligand for VEGFR2
score: 1.6129782, Bioorganic & Medicinal Chemistry Letters, 2012, Prabhakaran, Jaya et. al.
The first total synthesis and biological evaluation of marine natural products ma’edamines A and B
score: 1.6129602, Bioorganic & Medicinal Chemistry Letters, 2013, Saha, Sanjay et. al.
Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375
score: 1.6127419, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Nyung et. al.
Synthesis of D-labeled naphthyliodoacetamide and application to quantitative peptide analysis by isotope differential mass spectrometry
score: 1.6126447, Bioorganic & Medicinal Chemistry Letters, 2006, Niwayama, Satomi et. al.
Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation
score: 1.6124645, European Journal of Medicinal Chemistry, 2012, Shi, Liqiao et. al.
Oxazolones: New tyrosinase inhibitors; synthesis and their structure–activity relationships
score: 1.6124292, Bioorganic & Medicinal Chemistry, 2006, Khan, Khalid Mohammed et. al.
Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study
score: 1.6121465, European Journal of Medicinal Chemistry, 2012, Sharma, Aditya; Pan, Archana
Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study
score: 1.6121465, European Journal of Medicinal Chemistry, 2012, Sharma, Aditya; Pan, Archana
Synthesis of new 6-alkylvinyl/arylalkylvinyl substituted 1,2,4-trioxanes active against multidrug-resistant malaria in mice
score: 1.6120574, Bioorganic & Medicinal Chemistry, 2004, Singh, Chandan; Gupta, Nitin; Puri, Sunil K.
Enzymatic synthesis of 8-vinyl- and 8-styryl-2′-deoxyguanosine modified DNA—novel fluorescent molecular probes
score: 1.6119327, Bioorganic & Medicinal Chemistry Letters, 2012, Holzberger, Bastian et. al.
Enzymatic synthesis of 8-vinyl- and 8-styryl-2′-deoxyguanosine modified DNA—novel fluorescent molecular probes
score: 1.6119327, Bioorganic & Medicinal Chemistry Letters, 2012, Holzberger, Bastian et. al.
Anticancer and radiosensitizing evaluation of some new pyranothiazole-Schiff bases bearing the biologically active sulfonamide moiety
score: 1.6117021, European Journal of Medicinal Chemistry, 2012, Ghorab, Mostafa M. et. al.
Anticancer and radiosensitizing evaluation of some new pyranothiazole-Schiff bases bearing the biologically active sulfonamide moiety
score: 1.6117021, European Journal of Medicinal Chemistry, 2012, Ghorab, Mostafa M. et. al.
Anticancer and radiosensitizing evaluation of some new pyranothiazole-Schiff bases bearing the biologically active sulfonamide moiety
score: 1.6117021, European Journal of Medicinal Chemistry, 2012, Ghorab, Mostafa M. et. al.
Cyclotheonamide derivatives: Synthesis and thrombin inhibition. Exploration of specific structure-function issues
score: 1.6116448, Bioorganic & Medicinal Chemistry, 1995, Maryanoff, Bruce E et. al.
Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors
score: 1.6114028, Bioorganic & Medicinal Chemistry Letters, 2012, Canales, Eda et. al.
Soluble polymer-supported synthesis of benzodiazepinones
score: 1.6113565, Bioorganic & Medicinal Chemistry Letters, 2002, Wu, Cheng-Yi; Sun, Chung-Ming
Quaternary salts of 4,3′ and 4,4′ bis-pyridinium monooximes: Synthesis and biological activity
score: 1.6109673, Bioorganic & Medicinal Chemistry Letters, 2005, Chennamaneni, Srinivas Rao et. al.
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists
score: 1.6106528, Bioorganic & Medicinal Chemistry Letters, 2012, Mittapalli, Gopi Kumar et. al.
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists
score: 1.6106528, Bioorganic & Medicinal Chemistry Letters, 2012, Mittapalli, Gopi Kumar et. al.
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists
score: 1.6106528, Bioorganic & Medicinal Chemistry Letters, 2012, Mittapalli, Gopi Kumar et. al.
In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci.
score: 1.6104833, Antimicrobial agents and chemotherapy, 2001, Hebeisen, P et. al.
Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[ b]thiophene series
score: 1.6102942, Bioorganic & Medicinal Chemistry, 2006, Queiroz, Maria-João R.P. et. al.
Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-Discodermolide
score: 1.6101522, Bioorganic & Medicinal Chemistry, 2003, Mı́nguez, José M. et. al.
Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles
score: 1.6101074, Bioorganic & Medicinal Chemistry Letters, 2012, Zelisko, Nataliya et. al.
Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles
score: 1.6101074, Bioorganic & Medicinal Chemistry Letters, 2012, Zelisko, Nataliya et. al.
Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles
score: 1.6101074, Bioorganic & Medicinal Chemistry Letters, 2012, Zelisko, Nataliya et. al.
Identification of novel angiogenesis inhibitors
score: 1.6100512, Bioorganic & Medicinal Chemistry Letters, 2005, Sridhar, Jayalakshmi et. al.
Affinity prediction on A 1 adenosine receptor agonists: The chemometric approach
score: 1.6099863, Bioorganic & Medicinal Chemistry, 2006, Fossa, Paola et. al.
Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indolo[2,1- b]quinazoline-6,12-dione derivatives in relation to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST procedures
score: 1.609956, Bioorganic & Medicinal Chemistry, 2002, Bhattacharjee, Apurba K et. al.
Synthesis and evaluation of the molluscicidal activity of the 5,6-dimethyl-dihydro-pyran-2,4-dione and 6-substituted analogous
score: 1.6099333, Bioorganic & Medicinal Chemistry, 2004, de Souza, Laura Cristiane et. al.
Molecular docking and synthesis of novel quinazoline analogues as inhibitors of transcription factors NF-κB activation and their anti-cancer activities
score: 1.609893, Bioorganic & Medicinal Chemistry, 2013, Xu, Lu; Russu, Wade A.
Three-dimensional structure of Plasmodium falciparum Ca 2+-ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6
score: 1.6098929, Bioorganic & Medicinal Chemistry Letters, 2005, Jung, Mankil; Kim, Hanjo; Nam, Ki Youp; No, Kyoung Tai
Parallel synthesis of 1,2,4-oxadiazoles using CDI activation
score: 1.6098448, Bioorganic & Medicinal Chemistry Letters, 1999, Deegan, Tracy L et. al.
Pyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay
score: 1.6097484, Bioorganic & Medicinal Chemistry Letters, 2012, Nakhi, Ali et. al.
Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?
score: 1.609598, Bioorganic & Medicinal Chemistry, 2005, Krungkrai, Jerapan et. al.
Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1
score: 1.6095948, Bioorganic & Medicinal Chemistry Letters, 2012, Trippier, Paul C. et. al.
Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1
score: 1.6095948, Bioorganic & Medicinal Chemistry Letters, 2012, Trippier, Paul C. et. al.
Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors
score: 1.6094036, Bioorganic & Medicinal Chemistry, 2002, Rydzewski, Robert M et. al.
Oxovanadium complexes with quinoline and pyridinone ligands: syntheses of the complexes and effect of alkyl chains on their apoptosis-inducing activity in leukemia cells
score: 1.6091396, Bioorganic & Medicinal Chemistry, 2012, Yamaguchi, Tomoko et. al.
Quantitative structure–activity relationship study using refractotopological state atom index on some neonicotinoid insecticides
score: 1.6090599, Bioorganic & Medicinal Chemistry, 2004, Debnath, Bikash et. al.
Potent Inhibition of Norovirus 3CL Protease by Peptidyl α-Ketoamides and α-Ketoheterocycles
score: 1.608761, Bioorganic & Medicinal Chemistry Letters, 2012, Mandadapu, Sivakoteswara Rao et. al.
Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity
score: 1.6086876, Bioorganic & Medicinal Chemistry, 1999, Njoroge, F.George et. al.
Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
score: 1.608515, European Journal of Medicinal Chemistry, 2012, Sumangala, V. et. al.
Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
score: 1.608515, European Journal of Medicinal Chemistry, 2012, Sumangala, V. et. al.
Structure–Activity Relationships of seco-Prezizaane Terpenoids in γ-Aminobutyric Acid Receptors of Houseflies and Rats
score: 1.6084183, Bioorganic & Medicinal Chemistry, 2002, Kuriyama, Tadahiko et. al.
Altering protein specificity: techniques and applications
score: 1.6083416, Bioorganic & Medicinal Chemistry, 2005, Antikainen, Nina M.; Martin, Stephen F.
Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors
score: 1.6083152, Bioorganic & Medicinal Chemistry Letters, 2004, Baxter, Andrew et. al.
Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.
score: 1.608231, Antimicrobial agents and chemotherapy, 2004, Dutschman, Ginger E et. al.
New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships
score: 1.6078258, European Journal of Medicinal Chemistry, 2012, Areias, Filipe et. al.
Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.
score: 1.6075701, Antimicrobial agents and chemotherapy, 2003, Chen, Xin et. al.
Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4
score: 1.6074859, Bioorganic & Medicinal Chemistry, 2005, Hazeldine, Stuart T. et. al.
Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione
score: 1.6074729, European Journal of Medicinal Chemistry, 2005, Lee, Hong Woo et. al.
Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
score: 1.6072543, European Journal of Medicinal Chemistry, 2012, Sumangala, V. et. al.
4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter
score: 1.6071675, Bioorganic & Medicinal Chemistry, 2012, Hulubei, Victoria et. al.
4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter
score: 1.6071675, Bioorganic & Medicinal Chemistry, 2012, Hulubei, Victoria et. al.
4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter
score: 1.6071675, Bioorganic & Medicinal Chemistry, 2012, Hulubei, Victoria et. al.
Manzamenones L–N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.
score: 1.6071657, Bioorganic & Medicinal Chemistry Letters, 2013, Kubota, Takaaki et. al.
Synthesis and antifungal activity of 6-arylthio-/6-Arylamino-4,7-dioxobenzothiazoles
score: 1.6070852, Bioorganic & Medicinal Chemistry, 2003, Ryu, Chung-Kyu et. al.
Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors
score: 1.6070081, Bioorganic & Medicinal Chemistry, 2004, Xiao, Xiangshu et. al.
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors
score: 1.6069807, Bioorganic & Medicinal Chemistry Letters, 2012, Malmström, Jonas et. al.
Synthesis of versatile chemical tools toward a structure/properties relationships study onto targeting colloids
score: 1.6069708, European Journal of Medicinal Chemistry, 2007, Jolimaitre, Pascale et. al.
Synthesis and biological evaluation of new homocamptothecin analogs
score: 1.6068432, European Journal of Medicinal Chemistry, 2012, Luo, Yu et. al.
Synthesis and biological evaluation of new homocamptothecin analogs
score: 1.6068432, European Journal of Medicinal Chemistry, 2012, Luo, Yu et. al.
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies
score: 1.6066912, European Journal of Medicinal Chemistry, 2012, Colotta, Vittoria et. al.
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies
score: 1.6066912, European Journal of Medicinal Chemistry, 2012, Colotta, Vittoria et. al.
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies
score: 1.6066912, European Journal of Medicinal Chemistry, 2012, Colotta, Vittoria et. al.
Discovery and Structure-Activity Analysis of Selective Estrogen Receptor Modulators via Similarity-Based Virtual Screening
score: 1.6066854, European Journal of Medicinal Chemistry, 2012, Shen, Jie et. al.
3D QSAR Markov model for drug-induced eosinophilia—theoretical prediction and preliminary experimental assay of the antimicrobial drug G1
score: 1.6064327, Bioorganic & Medicinal Chemistry, 2005, González-Díaz, Humberto et. al.
Targeting prostate cancer cells with a multivalent PSMA inhibitor-guided streptavidin conjugate
score: 1.6062344, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Tiancheng et. al.
Targeting prostate cancer cells with a multivalent PSMA inhibitor-guided streptavidin conjugate
score: 1.6062344, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Tiancheng et. al.
Targeting prostate cancer cells with a multivalent PSMA inhibitor-guided streptavidin conjugate
score: 1.6062344, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Tiancheng et. al.
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents
score: 1.6061583, Bioorganic & Medicinal Chemistry, 2006, Gauthier, Charles et. al.
Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries
score: 1.6061406, Bioorganic & Medicinal Chemistry, 2005, André, Sabine et. al.
Synthesis of novel 4-substituted-7-trifluoromethylquinoline derivatives with nitric oxide releasing properties and their evaluation as analgesic and anti-inflammatory agents
score: 1.6060542, Bioorganic & Medicinal Chemistry, 2005, Abadi, Ashraf H.; Hegazy, Gehan H.; El-Zaher, Asmaa A.
Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors
score: 1.6060356, Bioorganic & Medicinal Chemistry, 2008, Tuccinardi, Tiziano et. al.
Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase
score: 1.6059651, Bioorganic & Medicinal Chemistry, 2006, Wang, Zhiyong; Silverman, Richard B.
Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs
score: 1.6055414, Bioorganic & Medicinal Chemistry Letters, 2012, Ngoc, Tran Minh et. al.
Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs
score: 1.6055414, Bioorganic & Medicinal Chemistry Letters, 2012, Ngoc, Tran Minh et. al.
Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.
score: 1.6053304, Antimicrobial agents and chemotherapy, 2001, Holz-Smith, S L et. al.
Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring
score: 1.6052724, European Journal of Medicinal Chemistry, 2003, Castro, Angeles et. al.
Antioxidant activity of synthetic cytokinin analogues: 6-alkynyl- and 6-alkenylpurines as novel 15-Lipoxygenase inhibitors
score: 1.6052693, Bioorganic & Medicinal Chemistry, 2002, Bråthe, Anders et. al.
Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecule
score: 1.6050257, Bioorganic & Medicinal Chemistry, 2005, Bellocchi, Daniele et. al.
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity
score: 1.6049279, European Journal of Medicinal Chemistry, 2012, Unsal-Tan, Oya et. al.
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity
score: 1.6049279, European Journal of Medicinal Chemistry, 2012, Unsal-Tan, Oya et. al.
Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array
score: 1.6048932, Bioorganic & Medicinal Chemistry, 2000, Ducruet, Alexander P et. al.
S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,d-arabinofuranosyl)adenine
score: 1.6048905, Bioorganic & Medicinal Chemistry Letters, 2012, Shokar, Ajit et. al.
S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,d-arabinofuranosyl)adenine
score: 1.6048905, Bioorganic & Medicinal Chemistry Letters, 2012, Shokar, Ajit et. al.
S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,d-arabinofuranosyl)adenine
score: 1.6048905, Bioorganic & Medicinal Chemistry Letters, 2012, Shokar, Ajit et. al.
Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8′-hydroxylase CYP707A
score: 1.604878, Bioorganic & Medicinal Chemistry Letters, 2009, Todoroki, Yasushi et. al.
Synthesis and evaluation of a 3-position diastereomer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D 3 (ED-71)
score: 1.6047688, Bioorganic & Medicinal Chemistry, 2006, Hatakeyama, Susumi et. al.
Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments
score: 1.6044682, European Journal of Medicinal Chemistry, 2012, Roldós, Virginia et. al.
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
score: 1.6044475, Antimicrobial agents and chemotherapy, 2004, Lorente, Silvia Orenes et. al.
New nordihydroguaiaretic acid derivatives as anti-HIV agents
score: 1.6044335, Bioorganic & Medicinal Chemistry Letters, 2008, Hwu, Jih Ru; Hsu, Ming-Hua; Huang, Ru Chih C.
A 3D-pharmacophore model for σ 2 receptors based on a series of substituted benzo[d]oxazol-2(3 H)-one derivatives
score: 1.6043342, Bioorganic & Medicinal Chemistry Letters, 2010, Laurini, Erik et. al.
Design, synthesis, and evaluation of mixed imine–amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity
score: 1.6041358, Bioorganic & Medicinal Chemistry, 2004, Kamal, Ahmed et. al.
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
score: 1.6040767, Bioorganic & Medicinal Chemistry, 2012, Kambe, Tohru et. al.
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
score: 1.6040767, Bioorganic & Medicinal Chemistry, 2012, Kambe, Tohru et. al.
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
score: 1.6040767, Bioorganic & Medicinal Chemistry, 2012, Kambe, Tohru et. al.
A simple method for coupling aldehydes to solid support
score: 1.6039372, Bioorganic & Medicinal Chemistry Letters, 1998, Metz, William A. et. al.
Studies on synthesis, stability, release and pharmacodynamic profile of a novel diacerein-thymol prodrug
score: 1.6037315, Bioorganic & Medicinal Chemistry Letters, 2013, Dhaneshwar, Suneela et. al.
Computational modeling and design of renin inhibitors
score: 1.6035671, Bioorganic & Medicinal Chemistry Letters, 2013, Subramanian, Govindan
Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives
score: 1.6034155, Bioorganic & Medicinal Chemistry, 2006, Chaudhary, Preeti et. al.
In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication.
score: 1.6032983, Antimicrobial agents and chemotherapy, 2002, Kati, Warren M et. al.
Indenoindolone derivatives as topoisomerase II–inhibiting anticancer agents
score: 1.6032095, Bioorganic & Medicinal Chemistry Letters, 2013, Kashyap, Maneesh et. al.
The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives
score: 1.6030955, Bioorganic & Medicinal Chemistry, 2012, Matyugina, Elena et. al.
The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives
score: 1.6030955, Bioorganic & Medicinal Chemistry, 2012, Matyugina, Elena et. al.
The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives
score: 1.6030955, Bioorganic & Medicinal Chemistry, 2012, Matyugina, Elena et. al.
Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities
score: 1.6028574, Bioorganic & Medicinal Chemistry Letters, 2012, Sipos, Attila et. al.
Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities
score: 1.6028574, Bioorganic & Medicinal Chemistry Letters, 2012, Sipos, Attila et. al.
Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities
score: 1.6028574, Bioorganic & Medicinal Chemistry Letters, 2012, Sipos, Attila et. al.
DNA and LNA oligonucleotides containing N2′-functionalised derivatives of 2′-amino-2′-deoxyuridine
score: 1.6028502, Bioorganic & Medicinal Chemistry Letters, 2006, Kalra, Neerja et. al.
Synthesis and evaluation of 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine mono- and diesters as potential prodrugs of penciclovir
score: 1.6028408, Bioorganic & Medicinal Chemistry, 1999, Kim, Dae-Kee et. al.
Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection
score: 1.6027615, Bioorganic & Medicinal Chemistry, 2012, Arce, Pablo M. et. al.
Ortho-azo substituted phenylboronic acids for colorimetric sugar sensors
score: 1.6026664, Bioorganic & Medicinal Chemistry Letters, 2007, Egawa, Yuya; Gotoh, Ryota; Niina, Satoshi; Anzai, Jun-ichi
Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.
score: 1.6024722, Antimicrobial agents and chemotherapy, 2011, Malik, Muhammad et. al.
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues
score: 1.6022642, Bioorganic & Medicinal Chemistry, 2005, Ostrowski, Tomasz et. al.
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II
score: 1.6021247, Bioorganic & Medicinal Chemistry, 2012, Mayadevi, M. et. al.
Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives
score: 1.6019714, Bioorganic & Medicinal Chemistry Letters, 2012, Mohan, Sahoo Biswa et. al.
Synthesis, characterization and biological activity of a niobium-substituted-heteropolytungstate on hepatitis B virus
score: 1.6018949, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Hong et. al.
Ciprofloxacin dimers target gyrase in Streptococcus pneumoniae.
score: 1.6018198, Antimicrobial agents and chemotherapy, 2004, Gould, Katherine A et. al.
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors
score: 1.6018188, European Journal of Medicinal Chemistry, 2005, Angibaud, Patrick et. al.
Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines
score: 1.6018168, Bioorganic & Medicinal Chemistry Letters, 2012, Venkat Ragavan, R. et. al.
Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines
score: 1.6018168, Bioorganic & Medicinal Chemistry Letters, 2012, Venkat Ragavan, R. et. al.
Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines
score: 1.6018168, Bioorganic & Medicinal Chemistry Letters, 2012, Venkat Ragavan, R. et. al.
Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase
score: 1.6015721, Bioorganic & Medicinal Chemistry, 2000, Peng, Hairuo et. al.
Urea/thiourea catalyzed, solvent-free synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones
score: 1.6014923, Bioorganic & Medicinal Chemistry Letters, 2012, Shah, Sakshi; Singh, Baldev
Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents
score: 1.6013562, European Journal of Medicinal Chemistry, 2012, Song, Ming-Xia et. al.
Preparation of potential inhibitors of the mur-Pathway enzymes on solid support using an acetal linker
score: 1.6013401, Bioorganic & Medicinal Chemistry Letters, 2003, Maletic, Milana et. al.
Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors
score: 1.6013314, European Journal of Medicinal Chemistry, 2002, Park, Chang Ha et. al.
Antimalarial activity of thioacridone compounds related to the acronycine alkaloid
score: 1.6012924, Bioorganic & Medicinal Chemistry, 2005, Dheyongera, James P. et. al.
Exploration of orally available calpain inhibitors: Peptidyl α-ketoamides containing an amphiphile at P3 site
score: 1.6012098, Bioorganic & Medicinal Chemistry, 2005, Shirasaki, Yoshihisa et. al.
Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors
score: 1.6010936, European Journal of Medicinal Chemistry, 2004, Cravotto, Giancarlo et. al.
Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker
score: 1.6009696, Bioorganic & Medicinal Chemistry, 2009, Chavain, Natascha et. al.
Antimycobacterial pyrroles: synthesis, anti- Mycobacterium tuberculosis activity and QSAR studies
score: 1.600904, Bioorganic & Medicinal Chemistry, 2000, Ragno, Rino et. al.
Antimicrobial activities of mefloquine and a series of related compounds.
score: 1.6007942, Antimicrobial agents and chemotherapy, 2000, Kunin, C M; Ellis, W Y
N-(3-Acyloxy-2-Benzylpropyl)- N′-Dihydroxytetrahydrobenzazepine and Tetrahydroisoquinoline Thiourea Analogues as Vanilloid Receptor Ligands
score: 1.6007929, Bioorganic & Medicinal Chemistry, 2001, Lee, Jeewoo et. al.
Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells
score: 1.6007662, European Journal of Medicinal Chemistry, 2009, Ishii, Yuta et. al.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: Synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies
score: 1.600745, Bioorganic & Medicinal Chemistry Letters, 2012, Nagase, Hiroshi et. al.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: Synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies
score: 1.600745, Bioorganic & Medicinal Chemistry Letters, 2012, Nagase, Hiroshi et. al.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: Synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies
score: 1.600745, Bioorganic & Medicinal Chemistry Letters, 2012, Nagase, Hiroshi et. al.
Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents
score: 1.600709, European Journal of Medicinal Chemistry, 2012, Csuk, René et. al.
Design and synthesis of manganese porphyrins with tailored lipophilicity: Investigation of redox properties and superoxide dismutase activity
score: 1.6005068, Bioorganic & Medicinal Chemistry, 2007, Lahaye, Dorothée et. al.
Potent 1,3-disubstituted-9 H-pyrido[3,4- b]indoles as new lead compounds in antifilarial chemotherapy 1 CDRI Communication No. 5795. 1
score: 1.6003754, Bioorganic & Medicinal Chemistry, 1999, Srivastava, Sanjay K. et. al.
Synthesis of condensed quinolines and quinazolines as DNA ligands
score: 1.6002533, Bioorganic & Medicinal Chemistry, 2004, Malecki, Natacha et. al.
Synthesis of diaryl-azo derivatives as potential antifungal agents
score: 1.5996087, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Hui; Zeng, Xiwen
Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity
score: 1.5995665, Bioorganic & Medicinal Chemistry, 2006, Szűčová, Lucie et. al.
A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies
score: 1.5992348, European Journal of Medicinal Chemistry, 2010, Tsai, Keng-Chang et. al.
Penicacids A–C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07
score: 1.5991614, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Ziming et. al.
Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: Enhanced enzymatic stability and biological properties
score: 1.5989621, European Journal of Medicinal Chemistry, 2012, Laimou, Despina et. al.
Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: Enhanced enzymatic stability and biological properties
score: 1.5989621, European Journal of Medicinal Chemistry, 2012, Laimou, Despina et. al.
Synthesis of some substituted pyrazinopyridoindoles and 3D QSAR studies along with related compounds: Piperazines, piperidines, pyrazinoisoquinolines, and diphenhydramine, and its semi-rigid analogs as antihistamines (H 1)
score: 1.598361, Bioorganic & Medicinal Chemistry, 2006, Saxena, Mridula et. al.
Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4′-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo
score: 1.5982111, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Hui; Wang, Juan-Juan
Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates
score: 1.5981583, Bioorganic & Medicinal Chemistry, 2003, Cai, Tingwei Bill et. al.
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents
score: 1.5980541, Bioorganic & Medicinal Chemistry Letters, 2012, Lama, Rati; Sandhu, Ranjodh; Zhong, Bo; Li, Bibo; Su, Bin
Synthesis and characterization of dinuclear macrocyclic cobalt(II), copper(II) and zinc(II) complexes derived from 2,2,2 ′,2 ′- S, S[bis(bis- N, N-2-thiobenzimidazolyloxalato-1,2-ethane)]: DNA binding and cleavage studies
score: 1.5980211, European Journal of Medicinal Chemistry, 2009, Arjmand, Farukh; Aziz, Mubashira
Synthesis and structure–activity relationship studies of cytotoxic vinorelbine amide analogues
score: 1.5980147, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Lingjun et. al.
Synthesis and structure–activity relationship studies of cytotoxic vinorelbine amide analogues
score: 1.5980147, Bioorganic & Medicinal Chemistry Letters, 2012, Hu, Lingjun et. al.
Liquid phase combinatorial synthesis of benzylpiperazines
score: 1.5980084, Bioorganic & Medicinal Chemistry Letters, 1999, Shey, Jing-Ying; Sun, Chung-Ming
Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives
score: 1.5979131, European Journal of Medicinal Chemistry, 2012, Shao, Jingwei et. al.
Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives
score: 1.5979131, European Journal of Medicinal Chemistry, 2012, Shao, Jingwei et. al.
The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection
score: 1.5978541, Bioorganic & Medicinal Chemistry, 2006, Liakatos, Angela et. al.
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2
score: 1.5978013, Bioorganic & Medicinal Chemistry Letters, 2012, Bakmiwewa, Supun M. et. al.
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2
score: 1.5978013, Bioorganic & Medicinal Chemistry Letters, 2012, Bakmiwewa, Supun M. et. al.
Novel 4,5-Diaryl-3-hydroxy-2(5 H)-furanones as Anti-Oxidants and Anti-Inflammatory Agents
score: 1.5977778, Bioorganic & Medicinal Chemistry, 2002, Weber, Valérie et. al.
3D QSAR studies on antimalarial alkoxylated and hydroxylated chalcones by CoMFA and CoMSIA
score: 1.5976273, European Journal of Medicinal Chemistry, 2004, Xue, C.X.; Cui, S.Y.; Liu, M.C.; Hu, Z.D.; Fan, B.T.
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety
score: 1.5975509, European Journal of Medicinal Chemistry, 2012, Tichý, Tomáš et. al.
Differences between the structural requirements for ABA 8′-hydroxylase inhibition and for ABA activity
score: 1.5974931, Bioorganic & Medicinal Chemistry, 2005, Ueno, Kotomi et. al.
5-(Sulfonyl)oxy-tryptamines and ethylamino side chain restricted derivatives. Structure–affinity relationships for h5-HT 1B and h5-HT 1D receptors
score: 1.5971837, Bioorganic & Medicinal Chemistry, 1998, Barf, Tjeerd et. al.
Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation
score: 1.5971449, European Journal of Medicinal Chemistry, 2012, Abdou, Wafaa M.; Barghash, Reham F.; Sediek, Ashraf A.
Solid-phase synthesis of an N-(phenylalkyl)cinnamide library via Horner–Wadsworth–Emmons reaction
score: 1.5969901, Bioorganic & Medicinal Chemistry Letters, 2004, Wéber, Csaba et. al.
Synthesis and characterization of a small analogue of the anticancer natural product leinamycin
score: 1.5969096, Bioorganic & Medicinal Chemistry, 2013, Keerthi, Kripa et. al.
Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans
score: 1.5968739, Bioorganic & Medicinal Chemistry, 2006, Pedras, M. Soledade. C.; Suchy, Mojmir
Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors
score: 1.5968433, Bioorganic & Medicinal Chemistry, 2003, Kazmierski, Wieslaw et. al.
4- N-Methyl- N′-(2-dihydroxyboryl-benzyl)amino benzonitrile and its boronate analogue sensing saccharides and fluoride ion
score: 1.5968174, Bioorganic & Medicinal Chemistry Letters, 2007, Tan, Wei; Zhang, Deqing; Zhu, Daoben
Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486.
score: 1.5966213, Antimicrobial agents and chemotherapy, 2005, White, Peter W et. al.
Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis.
score: 1.5966043, Antimicrobial agents and chemotherapy, 2001, Coombs, G H; Mottram, J C
Syntheses of Ferulic Acid Derivatives and Their Suppressive Effects on Cyclooxygenase-2 Promoter Activity
score: 1.5964557, Bioorganic & Medicinal Chemistry, 2002, Hosoda, Asao et. al.
Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1
score: 1.5958263, European Journal of Medicinal Chemistry, 2012, Ventosa-Andrés, Pilar et. al.
Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1
score: 1.5958263, European Journal of Medicinal Chemistry, 2012, Ventosa-Andrés, Pilar et. al.
Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1
score: 1.5958263, European Journal of Medicinal Chemistry, 2012, Ventosa-Andrés, Pilar et. al.
Structure–activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs
score: 1.5957397, Bioorganic & Medicinal Chemistry, 2004, Scapecchi, Serena et. al.
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR
score: 1.5957335, Bioorganic & Medicinal Chemistry Letters, 2012, Martínez González, Sonia et. al.
Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: synthesis and biological activities of triazine derivatives
score: 1.5957088, Bioorganic & Medicinal Chemistry, 1999, Leroux, F et. al.
Synthesis, cytotoxic activities and cell cycle arrest profiles of half-sandwich N-sulfonamide based dithio-o-carborane metal complexes
score: 1.5957008, Bioorganic & Medicinal Chemistry, 2012, Dou, Huan et. al.
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer’s disease
score: 1.5956504, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Yong Dae et. al.
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1
score: 1.595613, Bioorganic & Medicinal Chemistry, 2013, Song, Ting et. al.
Studies on scavenger receptor inhibitors. Part 1: synthesis and structure–activity relationships of novel derivatives of sulfatides
score: 1.5955876, Bioorganic & Medicinal Chemistry, 2002, Yoshiizumi, Kazuya et. al.
Is it possible docking and scoring new ligands with few experimental data? Preliminary results on estrogen receptor as a case study
score: 1.5955387, European Journal of Medicinal Chemistry, 2004, Cozzini, P; Dottorini, T
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: Synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities
score: 1.5954854, European Journal of Medicinal Chemistry, 2012, Kaur, Kirandeep et. al.
Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors
score: 1.5954231, Bioorganic & Medicinal Chemistry Letters, 2012, Xiang, Yang-Fei et. al.
Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors
score: 1.5954231, Bioorganic & Medicinal Chemistry Letters, 2012, Xiang, Yang-Fei et. al.
Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors
score: 1.5954231, Bioorganic & Medicinal Chemistry Letters, 2012, Xiang, Yang-Fei et. al.
Photocleavage coupling reactions between cyclohexa-2,4-dienone sulfone derivatives and amines by visible light irradiation
score: 1.5953543, Bioorganic & Medicinal Chemistry Letters, 1999, Kim, Young Mee et. al.
In silico prediction of brain and CSF permeation of small molecules using PLS regression models
score: 1.5953376, European Journal of Medicinal Chemistry, 2008, Bendels, Stefanie et. al.
Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives
score: 1.5953083, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lisheng et. al.
Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives
score: 1.5953083, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lisheng et. al.
Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives
score: 1.5953083, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lisheng et. al.
Synthesis and structure–affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor 1 receptor antagonists
score: 1.5952828, Bioorganic & Medicinal Chemistry, 2001, Kumagai, Toshihito et. al.
Structure–activity relationship exploration of Kv1.3 blockers based on diphenoxylate
score: 1.5951714, Bioorganic & Medicinal Chemistry Letters, 2012, Nguyen, William et. al.
Inhibitors of HIV-1 attachment. Part 9: An assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative
score: 1.5951402, Bioorganic & Medicinal Chemistry Letters, 2013, Yeung, Kap-Sun et. al.
Syntheses of fused heterocyclic compounds and their inhibitory activities for squalene synthase
score: 1.5951031, Bioorganic & Medicinal Chemistry, 2002, Miki, Takashi et. al.
Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3- b]thiophen-4,9-quinones
score: 1.5950011, Bioorganic & Medicinal Chemistry, 1997, Zani, Carlos L. et. al.
Pyridazines. Part XXIX: synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2 H)-pyridazinones. Novel aspects of their biological actions
score: 1.5948607, Bioorganic & Medicinal Chemistry, 2002, Sotelo, Eddy et. al.
1 H-Imidazo[4,5- c]quinoline derivatives as novel potent TNF-α suppressors: synthesis and structure–activity relationship of 1-, 2-and 4-substituted 1 H-imidazo[4,5- c]quinolines or 1 H-imidazo[4,5- c]pyridines
score: 1.5948532, Bioorganic & Medicinal Chemistry, 2003, Izumi, Tomoyuki et. al.
New triterpenoid saponins from cacti and anti-type I allergy activity of saponins from cactus
score: 1.5948179, Bioorganic & Medicinal Chemistry Letters, 2012, Kakuta, Kazutaka et. al.
New triterpenoid saponins from cacti and anti-type I allergy activity of saponins from cactus
score: 1.5948179, Bioorganic & Medicinal Chemistry Letters, 2012, Kakuta, Kazutaka et. al.
Exploration of cathepsin S inhibitors characterized by a triazole P1–P2 amide replacement
score: 1.5941937, Bioorganic & Medicinal Chemistry Letters, 2012, Moss, Neil et. al.
Exploration of cathepsin S inhibitors characterized by a triazole P1–P2 amide replacement
score: 1.5941937, Bioorganic & Medicinal Chemistry Letters, 2012, Moss, Neil et. al.
Exploration of cathepsin S inhibitors characterized by a triazole P1–P2 amide replacement
score: 1.5941937, Bioorganic & Medicinal Chemistry Letters, 2012, Moss, Neil et. al.
New triterpenoid saponins from cacti and anti-type I allergy activity of saponins from cactus
score: 1.5941917, Bioorganic & Medicinal Chemistry Letters, 2012, Kakuta, Kazutaka et. al.
Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
score: 1.5940911, Bioorganic & Medicinal Chemistry, 2012, Chen, Wei-Jia et. al.
Optimization of tocotrienols as antiproliferative and antimigratory leads
score: 1.593953, European Journal of Medicinal Chemistry, 2013, Behery, Fathy A. et. al.
Optimization of tocotrienols as antiproliferative and antimigratory leads
score: 1.593953, European Journal of Medicinal Chemistry, 2013, Behery, Fathy A. et. al.
Synthesis and evaluation of indole-containing 3,5-diarylisoxazoles as potential pro-apoptotic antitumour agents
score: 1.5935988, European Journal of Medicinal Chemistry, 2012, Md Tohid, Siti Farah et. al.
Synthesis and evaluation of indole-containing 3,5-diarylisoxazoles as potential pro-apoptotic antitumour agents
score: 1.5935988, European Journal of Medicinal Chemistry, 2012, Md Tohid, Siti Farah et. al.
Using the Golden Triangle to optimize clearance and oral absorption
score: 1.5935872, Bioorganic & Medicinal Chemistry Letters, 2009, Johnson, Ted W.; Dress, Klaus R.; Edwards, Martin
Synthesis and structure–activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents
score: 1.593144, Bioorganic & Medicinal Chemistry, 2003, Noguchi, Toshiya et. al.
Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety
score: 1.5931321, European Journal of Medicinal Chemistry, 2012, He, Junbo et. al.
Peptide-based inhibitors of hepatitis C virus full-length NS3 (protease-helicase/NTPase): model compounds towards small molecule inhibitors
score: 1.5930007, Bioorganic & Medicinal Chemistry, 2003, Oscarsson, Karin et. al.
QSAR studies on biological activity of piritrexim analogues against pc DHFR
score: 1.5928842, Bioorganic & Medicinal Chemistry, 2002, Agrawal, Vijay K.; Sohgaura, Rashmi; Khadikar, Padmakar V.
S-adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine
score: 1.5928778, Bioorganic & Medicinal Chemistry Letters, 2012, Shokar, Ajit et. al.
Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select.
score: 1.5927525, Antimicrobial agents and chemotherapy, 2011, Porsby, Cisse Hedegaard et. al.
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives
score: 1.5925639, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Xuefei et. al.
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives
score: 1.5925639, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Xuefei et. al.
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives
score: 1.5925639, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Xuefei et. al.
Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides
score: 1.5921235, Bioorganic & Medicinal Chemistry Letters, 2012, Stokes, Suzanne S. et. al.
Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides
score: 1.5921235, Bioorganic & Medicinal Chemistry Letters, 2012, Stokes, Suzanne S. et. al.
Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides
score: 1.5921235, Bioorganic & Medicinal Chemistry Letters, 2012, Stokes, Suzanne S. et. al.
The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product
score: 1.5917677, Bioorganic & Medicinal Chemistry Letters, 2012, Sivaramakrishnan, Santhosh et. al.
Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.
score: 1.5916962, Antimicrobial agents and chemotherapy, 2005, Dorr, Patrick et. al.
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
score: 1.5915731, European Journal of Medicinal Chemistry, 2012, Bertinaria, Massimo et. al.
Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines
score: 1.5914548, Bioorganic & Medicinal Chemistry, 2012, Pédeboscq, Stéphane et. al.
Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines
score: 1.5914548, Bioorganic & Medicinal Chemistry, 2012, Pédeboscq, Stéphane et. al.
Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines
score: 1.5914548, Bioorganic & Medicinal Chemistry, 2012, Pédeboscq, Stéphane et. al.
6-Dimethylamino 1H-Pyrazolo[3,4- d]pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells
score: 1.5914121, Bioorganic & Medicinal Chemistry, 2003, Quintela, José M et. al.
Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide
score: 1.5913963, Bioorganic & Medicinal Chemistry Letters, 2005, Machado, Alexandre Légora et. al.
Antiproliferative and apoptotic effects of compounds from the flower of Mammea siamensis (Miq.) T. Anders. on human cancer cell lines
score: 1.5912989, Bioorganic & Medicinal Chemistry Letters, 2013, Tung, Nguyen Huu et. al.
Thiosemicarbazone fragment embedded within 1,2,4-triazole ring as inhibitors of Entamoeba histolytica
score: 1.5912131, Bioorganic & Medicinal Chemistry Letters, 2012, Siddiqui, Shadab Miyan; Salahuddin, Attar; Azam, Amir
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor
score: 1.591015, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Shang-Ke et. al.
Structural insights into IKKβ inhibition by natural products staurosporine and quercetin
score: 1.5909445, Bioorganic & Medicinal Chemistry Letters, 2009, Avila, Carolina M. et. al.
Identification of novel PPARα ligands by the structural modification of a PPARγ ligand
score: 1.5909159, Bioorganic & Medicinal Chemistry Letters, 2006, Usui, Shinya et. al.
Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α1-adrenoceptor antagonistic properties
score: 1.590889, Bioorganic & Medicinal Chemistry, 2012, Handzlik, Jadwiga et. al.
Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles
score: 1.5907343, Bioorganic & Medicinal Chemistry Letters, 2012, Zelisko, Nataliya et. al.
Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer
score: 1.5906642, European Journal of Medicinal Chemistry, 2012, Virgilio, Antonella et. al.
3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method
score: 1.590541, Bioorganic & Medicinal Chemistry, 2005, Temiz-Arpaci, Ozlem et. al.
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor
score: 1.5903887, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Shang-Ke et. al.
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor
score: 1.5903887, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Shang-Ke et. al.
A novel fluorescent sensor for triplex DNA
score: 1.5903166, Bioorganic & Medicinal Chemistry Letters, 2005, Lu, Erhu; Peng, Xiaojun; Song, Fengling; Fan, Jiangli
Synthesis, receptor binding affinities and conformational properties of cyclic methylenedithioether analogues of angiotensin II
score: 1.5902846, Bioorganic & Medicinal Chemistry, 2001, Lindman, Susanna et. al.
Synthesis and Anti-norovirus Activity of Pyranobenzopyrone Compounds
score: 1.5902247, Bioorganic & Medicinal Chemistry Letters, 2012, Pokhrel, Laxman et. al.
Substituted benz[ a]acridines and benz[ c]acridines as mammalian topoisomerase poisons
score: 1.5900557, Bioorganic & Medicinal Chemistry, 2000, Makhey, Darshan et. al.
Between a rock and a hard place?
score: 1.5900488, Nature chemical biology, 2006, Whitty, Adrian; Kumaravel, Gnanasambandam
Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate
score: 1.5898479, Bioorganic & Medicinal Chemistry Letters, 2012, Suneela, Dhaneshwar; Dipmala, Patil
A new pancreatic lipase inhibitor from Broussonetia kanzinoki
score: 1.5896554, Bioorganic & Medicinal Chemistry Letters, 2012, Ahn, Jong Hoon et. al.
Dual PPAR-α and -γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential
score: 1.5896186, Bioorganic & Medicinal Chemistry, 2006, Madhavan, Gurram R. et. al.
New bis(pyridyl)methane derivatives from 4-hydroxy-2-pyridones: synthesis and antitumoral activity
score: 1.589596, European Journal of Medicinal Chemistry, 2003, Cocco, Maria Teresa; Congiu, Cenzo; Onnis, Valentina
Synthesis and in vitro evaluation of [18F](R)-FEPAQ: A potential PET ligand for VEGFR2
score: 1.5895057, Bioorganic & Medicinal Chemistry Letters, 2012, Prabhakaran, Jaya et. al.
Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain
score: 1.5894058, Bioorganic & Medicinal Chemistry, 2003, Springsteel, Mark F et. al.
Structure–activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na +,K +-ATPase and binding to the central benzodiazepine receptor
score: 1.5891117, Bioorganic & Medicinal Chemistry, 2006, Pôças, Elisa S.C. et. al.
Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1- c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy
score: 1.5890817, Bioorganic & Medicinal Chemistry, 2006, Guerrini, Gabriella et. al.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
score: 1.5889715, Bioorganic & Medicinal Chemistry Letters, 2012, Wollinsky, Beate et. al.
Anthranilic acid-based diamides derivatives Incorporating aryl-isoxazoline pharmacophore as potential anti-cancer agents: Design, synthesis and biological evaluation
score: 1.5889666, European Journal of Medicinal Chemistry, 2012, Shi, Liqiao et. al.
Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives
score: 1.5889152, Bioorganic & Medicinal Chemistry, 2000, Martı́nez, Ana et. al.
1,2,4-Thiadiazole: A novel Cathepsin B inhibitor
score: 1.5888767, Bioorganic & Medicinal Chemistry, 2003, Leung-Toung, Regis et. al.
Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents
score: 1.5887784, Bioorganic & Medicinal Chemistry, 2012, Zhao, Ting-Ting et. al.
Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents
score: 1.5887784, Bioorganic & Medicinal Chemistry, 2012, Zhao, Ting-Ting et. al.
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors
score: 1.5886807, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Kyeong et. al.
Arylimino-1,2,4-thiadiazolidinones: A new family of potassium channel openers
score: 1.5886585, Bioorganic & Medicinal Chemistry, 1997, Martínez, Ana et. al.
Antiplasmodial activities of 4-aminoquinoline–statine compounds
score: 1.5886544, Bioorganic & Medicinal Chemistry Letters, 2012, Vaiana, Nadia et. al.
Novel RGD-like molecules based on the tyrosine template: design, synthesis, and biological evaluation on isolated integrins α Vβ 3/α IIbβ 3 and in cellular adhesion tests
score: 1.588456, Bioorganic & Medicinal Chemistry, 2004, Biltresse, Stephane et. al.
Synthesis of 7-amino-3a,4-dihydro-3 H-[1]benzopyrano[4,3- c]isoxazole derivatives displaying combined α 2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities
score: 1.5881588, Bioorganic & Medicinal Chemistry, 2006, Andrés, J. Ignacio et. al.
Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions
score: 1.5880959, Bioorganic & Medicinal Chemistry Letters, 2008, Buller, Fabian et. al.
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand
score: 1.5880952, Bioorganic & Medicinal Chemistry, 2012, Clark, Alia H. et. al.
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand
score: 1.5880952, Bioorganic & Medicinal Chemistry, 2012, Clark, Alia H. et. al.
Discovery and optimization of nonpeptide HIV-1 protease inhibitors
score: 1.5880652, Bioorganic & Medicinal Chemistry, 1996, Tummino, Peter J. et. al.
Synthesis and SAR of 2′,3′-bis-O-substituted N6, 5′-bis-ureidoadenosine derivatives: Implications for prodrug delivery and mechanism of action
score: 1.5880183, Bioorganic & Medicinal Chemistry Letters, 2012, Shelton, Jadd R. et. al.
Structural requirements for the antitubercular quaternized triflupromazine pharmacophore
score: 1.5880155, Bioorganic & Medicinal Chemistry Letters, 2012, Kunciw, Dominique L. et. al.
VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells.
score: 1.587974, Antimicrobial agents and chemotherapy, 2006, Lin, Kai; Perni, Robert B; Kwong, Ann D; Lin, Chao
Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents
score: 1.587581, Bioorganic & Medicinal Chemistry, 2012, Liu, Yingqian et. al.
Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents
score: 1.587581, Bioorganic & Medicinal Chemistry, 2012, Liu, Yingqian et. al.
Tormentic acid derivatives: Synthesis and apoptotic activity
score: 1.5874853, European Journal of Medicinal Chemistry, 2012, Csuk, René et. al.
Tormentic acid derivatives: Synthesis and apoptotic activity
score: 1.5874853, European Journal of Medicinal Chemistry, 2012, Csuk, René et. al.
Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease
score: 1.5873383, Bioorganic & Medicinal Chemistry, 2003, Nagarajan, Srinivasan R et. al.
Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication
score: 1.5872509, Bioorganic & Medicinal Chemistry, 1999, Slater, Martin J. et. al.
Synthesis and antimalarial activities of base-catalyzed adducts of 11-azaartemisinin
score: 1.5871629, Bioorganic & Medicinal Chemistry, 2000, Mekonnen, Belew et. al.
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels−Alder reaction
score: 1.5868025, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng et. al.
Oxoquinoline acyclonucleoside phosphonate analogues as a new class of specific inhibitors of human immunodeficiency virus type 1
score: 1.586748, Bioorganic & Medicinal Chemistry Letters, 2012, Faro, Letícia V. et. al.
Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity
score: 1.5864206, European Journal of Medicinal Chemistry, 2012, Abonia, Rodrigo et. al.
Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity
score: 1.5864206, European Journal of Medicinal Chemistry, 2012, Abonia, Rodrigo et. al.
Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription
score: 1.5863816, European Journal of Medicinal Chemistry, 2012, Osorio, Alex A. et. al.
Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription
score: 1.5863816, European Journal of Medicinal Chemistry, 2012, Osorio, Alex A. et. al.
Salen-anthraquinone Conjugates. Synthesis, DNA-binding and cleaving properties, effects on topoisomerases and cytotoxicity
score: 1.5862439, Bioorganic & Medicinal Chemistry, 1996, Routier, Sylvain et. al.
Appraisal of GABA and PABA as linker: Design and synthesis of novel benzamide based histone deacetylase inhibitors
score: 1.5862021, European Journal of Medicinal Chemistry, 2012, Rajak, Harish et. al.
Appraisal of GABA and PABA as linker: Design and synthesis of novel benzamide based histone deacetylase inhibitors
score: 1.5862021, European Journal of Medicinal Chemistry, 2012, Rajak, Harish et. al.
Design, synthesis, and evaluation of (E)-N-substituted benzylidene–aniline derivatives as tyrosinase inhibitors
score: 1.5860765, European Journal of Medicinal Chemistry, 2012, Bae, Sung Jin et. al.
Design, synthesis, and evaluation of (E)-N-substituted benzylidene–aniline derivatives as tyrosinase inhibitors
score: 1.5860765, European Journal of Medicinal Chemistry, 2012, Bae, Sung Jin et. al.
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes.
score: 1.5860764, Antimicrobial agents and chemotherapy, 2006, Mathis, Amanda M et. al.
Design, synthesis, and biological evaluation of simplified α-Keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase
score: 1.5859326, Bioorganic & Medicinal Chemistry, 2003, Marsilje, Thomas H et. al.
Synthesis and Characterization of Pyruvate-Isoniazid Analogs and their Copper Complexes as Potential ICL Inhibitors
score: 1.5858084, Bioorganic & Medicinal Chemistry Letters, 2012, Shingnapurkar, Dipti et. al.
Organocatalytic enantioselective hetero-Diels–Alder reaction of aldehydes and o-benzoquinone diimide: Synthesis of optically active hydroquinoxalines
score: 1.585735, Bioorganic & Medicinal Chemistry Letters, 2009, Li, Jun-Long; Han, Bo; Jiang, Kun; Du, Wei; Chen, Ying-Chun
Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands
score: 1.5857292, Bioorganic & Medicinal Chemistry Letters, 2006, Gao, Mingzhang et. al.
Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety
score: 1.5853178, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Pei-Liang et. al.
Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety
score: 1.5853178, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Pei-Liang et. al.
Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety
score: 1.5853178, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Pei-Liang et. al.
Synthesis and anti-hyperglycemic activity of hesperidin derivatives
score: 1.5847913, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Baoshun et. al.
Synthesis and anti-hyperglycemic activity of hesperidin derivatives
score: 1.5847913, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Baoshun et. al.
Synthesis and anti-hyperglycemic activity of hesperidin derivatives
score: 1.5847913, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Baoshun et. al.
Quantitative structure–activity relationship studies of vitamin D receptor affinity for analogues of 1α,25-dihydroxyvitamin D 3. 1: WHIM descriptors
score: 1.5847399, Bioorganic & Medicinal Chemistry Letters, 2005, González, Maykel Pérez et. al.
Novel structural insights for imidoselenocarbamates with antitumoral activity related to their ability to generate methylselenol
score: 1.5846844, Bioorganic & Medicinal Chemistry, 2012, Font, María et. al.
A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain α-galactosyltransferases
score: 1.5846032, Bioorganic & Medicinal Chemistry Letters, 1998, Brown, Jillian R. et. al.
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues
score: 1.5845429, Bioorganic & Medicinal Chemistry, 2005, Bedini, Annalida et. al.
Asymmetric synthesis of the stereoisomers of 11,12,15( S)-trihydroxyeicosa-5( Z),8( Z),13( E)-trienoic acid, a potent endothelium-derived vasodilator
score: 1.5842942, Bioorganic & Medicinal Chemistry Letters, 2004, Falck, J.R. et. al.
Novel multi-functional nitrones for treatment of ischemic stroke
score: 1.5842106, Bioorganic & Medicinal Chemistry, 2012, Sun, Yewei et. al.
Novel multi-functional nitrones for treatment of ischemic stroke
score: 1.5842106, Bioorganic & Medicinal Chemistry, 2012, Sun, Yewei et. al.
Novel multi-functional nitrones for treatment of ischemic stroke
score: 1.5842106, Bioorganic & Medicinal Chemistry, 2012, Sun, Yewei et. al.
Synthesis, cytotoxic activities and cell cycle arrest profiles of half-sandwich N-sulfonamide based dithio-o-carborane metal complexes
score: 1.5841237, Bioorganic & Medicinal Chemistry, 2012, Dou, Huan et. al.
Oxidised derivatives of silybin and their antiradical and antioxidant activity
score: 1.5840036, Bioorganic & Medicinal Chemistry, 2004, Gažák, Radek et. al.
1,2,3,4-Tetrahydroisoquinoline Derivatives: A New Class of 5-HT 1A Receptor Ligands 1 Part 34 of the series: structure–activity relationship studies of CNS agents. 1
score: 1.5839461, Bioorganic & Medicinal Chemistry, 1999, Mokrosz, Maria J. et. al.
Syntheses and cytotoxicity evaluation of bis(indolyl)thiazole, bis(indolyl)pyrazinone and bis(indolyl)pyrazine: analogues of cytotoxic marine bis(indole) alkaloid
score: 1.5839052, Bioorganic & Medicinal Chemistry, 2000, Jiang, Biao; Gu, Xiao-Hui
Synthesis of sialyllactosamine clusters using carbosilane as core scaffolds by means of chemical and enzymatic approaches
score: 1.583744, Bioorganic & Medicinal Chemistry Letters, 2010, Matsuoka, Koji et. al.
The antibacterial activity of 4,4′-bipyridinium amphiphiles with conventional, bicephalic and gemini architectures
score: 1.5837156, Bioorganic & Medicinal Chemistry Letters, 2012, Grenier, Melissa C. et. al.
The antibacterial activity of 4,4′-bipyridinium amphiphiles with conventional, bicephalic and gemini architectures
score: 1.5837156, Bioorganic & Medicinal Chemistry Letters, 2012, Grenier, Melissa C. et. al.
Synthesis and evaluation of [18F]Fluorobutyl ethacrynic amide: A potential PET tracer for studying glutathione transferase
score: 1.5837125, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Ho-Lien et. al.
Synthesis and evaluation of [18F]Fluorobutyl ethacrynic amide: A potential PET tracer for studying glutathione transferase
score: 1.5837125, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Ho-Lien et. al.
Synthesis and evaluation of [18F]Fluorobutyl ethacrynic amide: A potential PET tracer for studying glutathione transferase
score: 1.5837125, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Ho-Lien et. al.
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents
score: 1.5835098, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ting et. al.
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents
score: 1.5835098, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ting et. al.
Alumina supported potassium permanganate: an efficient reagent for chemoselective dehydrogenation of 2-imidazolines under mild conditions
score: 1.5832394, Bioorganic & Medicinal Chemistry Letters, 2004, Abdollahi-Alibeik, Mohammad et. al.
Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors
score: 1.5832167, Bioorganic & Medicinal Chemistry, 2003, Zoeiby, Ahmed El et. al.
Targeting Prostate Cancer Cells with a Multivalent PSMA Inhibitor-Guided Streptavidin Conjugate
score: 1.5831113, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Tiancheng et. al.
Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties
score: 1.5829564, Bioorganic & Medicinal Chemistry Letters, 2013, Carroux, Cindy J. et. al.
Benzothiazoles: Search for anticancer agents
score: 1.582916, European Journal of Medicinal Chemistry, 2012, Noolvi, Malleshappa N.; Patel, Harun M.; Kaur, Manpreet
Benzothiazoles: Search for anticancer agents
score: 1.582916, European Journal of Medicinal Chemistry, 2012, Noolvi, Malleshappa N.; Patel, Harun M.; Kaur, Manpreet
Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.
score: 1.5827831, Antimicrobial agents and chemotherapy, 2005, Shen, Linus L et. al.
In vitro antiplasmodium effects of dermaseptin S4 derivatives.
score: 1.5827182, Antimicrobial agents and chemotherapy, 2002, Dagan, Arie et. al.
Synthesis and molecular modeling studies of novel carbapeptide analogs for inhibition of HIV-1 protease
score: 1.5826707, European Journal of Medicinal Chemistry, 2012, Pawar, Sachin A. et. al.
An efficient asymmetric synthesis of ( S)-atenolol: using hydrolytic kinetic resolution
score: 1.5825153, Bioorganic & Medicinal Chemistry, 2005, Subhas Bose, D.; Venkat Narsaiah, A.
Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives
score: 1.582458, European Journal of Medicinal Chemistry, 2004, Dyla¸g, Tomasz et. al.
Fluorometric detection of adenine in target DNA by exciplex formation with fluorescent 8-arylethynylated deoxyguanosine
score: 1.5822921, Bioorganic & Medicinal Chemistry Letters, 2012, Saito, Yoshio et. al.
Fluorometric detection of adenine in target DNA by exciplex formation with fluorescent 8-arylethynylated deoxyguanosine
score: 1.5822921, Bioorganic & Medicinal Chemistry Letters, 2012, Saito, Yoshio et. al.
Fluorometric detection of adenine in target DNA by exciplex formation with fluorescent 8-arylethynylated deoxyguanosine
score: 1.5822921, Bioorganic & Medicinal Chemistry Letters, 2012, Saito, Yoshio et. al.
Synthesis and mannose receptor-Mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge
score: 1.5822373, Bioorganic & Medicinal Chemistry Letters, 2002, Angyalosi, Gerhild et. al.
Synthesis and structure-activity relationships of dual histamine H 2 and gastrin receptor antagonists with modified benzodiazepine skeletons
score: 1.5821272, Bioorganic & Medicinal Chemistry, 1997, Kawanishi, Yasuyuki et. al.
Design of Inhibitors of Scytalone Dehydratase: Probing Interactions with an Asparagine Carboxamide
score: 1.582029, Bioorganic & Medicinal Chemistry, 2002, Basarab, Gregory S et. al.
Synthesis of diether-linked cationic lipids for gene delivery
score: 1.5819319, Bioorganic & Medicinal Chemistry Letters, 1999, Ren, Tan; Liu, Dexi
α-Rhamnosidase inhibitory activities of polyhydroxylated pyrrolidine
score: 1.5817936, Bioorganic & Medicinal Chemistry Letters, 2005, Kim, Jin Hyo et. al.
Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates
score: 1.5817785, Bioorganic & Medicinal Chemistry Letters, 2008, Efthimiadou, Eleni K. et. al.
Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy 1 This paper is dedicated with admiration and respect to the memory of Sir Derek H. R. Barton. 1
score: 1.5817315, Bioorganic & Medicinal Chemistry, 1999, Nicolaou, K.C. et. al.
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D 4 receptor agonists
score: 1.5816822, Bioorganic & Medicinal Chemistry, 2005, Wang, Xueqing et. al.
MAO inhibition by arylisopropylamines: the effect of oxygen substituents at the β-position
score: 1.5815996, Bioorganic & Medicinal Chemistry, 2004, Osorio-Olivares, Mauricio et. al.
Modeling of activity of cyclic urea HIV-1 protease inhibitors using regularized-artificial neural networks
score: 1.5814312, Bioorganic & Medicinal Chemistry, 2006, Fernández, Michael; Caballero, Julio
In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068.
score: 1.5813276, Antimicrobial agents and chemotherapy, 2012, Nowicka-Sans, Beata et. al.
Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses.
score: 1.5810208, Antimicrobial agents and chemotherapy, 2011, Kumar, Naveen et. al.
Branched aminoglycosides: Biochemical studies and antibacterial activity of neomycin B derivatives
score: 1.5810177, Bioorganic & Medicinal Chemistry, 2005, Hainrichson, Mariana et. al.
Benzophenone boronic acid photoaffinity labeling of subtilisin CMMs to probe altered specificity
score: 1.5808921, Bioorganic & Medicinal Chemistry, 2000, DeSantis, Grace; Paech, Christian; Jones, J.Bryan
Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry–activity relationship
score: 1.5808696, Bioorganic & Medicinal Chemistry, 2012, Ohashi, Masao et. al.
Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry–activity relationship
score: 1.5808696, Bioorganic & Medicinal Chemistry, 2012, Ohashi, Masao et. al.
Synthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-β type 1 receptor kinase inhibitors
score: 1.5808391, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang
Structure–activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors
score: 1.5808081, Bioorganic & Medicinal Chemistry, 2006, Virga, Kristopher G. et. al.
Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives
score: 1.5806072, Bioorganic & Medicinal Chemistry, 2005, Rao, Yerra Koteswara; Fang, Shih-Hua; Tzeng, Yew-Min
Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds
score: 1.5804612, Bioorganic & Medicinal Chemistry, 2005, Hossain, Sk. Ugir; Sengupta, Sumitra; Bhattacharya, Sudin
An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer
score: 1.5803211, Bioorganic & Medicinal Chemistry, 2006, Hashimoto, Masaru et. al.
Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase
score: 1.5799794, European Journal of Medicinal Chemistry, 2013, Meng, Hu; Liu, Ying; Zhai, Yujing; Lai, Luhua
Aqua mediated synthesis of substituted 2-amino-4H-chromenes catalyzed by green and reusable Preyssler heteropolyacid
score: 1.5799156, Bioorganic & Medicinal Chemistry Letters, 2007, Heravi, Majid M. et. al.
A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors
score: 1.5798216, Bioorganic & Medicinal Chemistry, 2006, Kawasuji, Takashi et. al.
Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives
score: 1.5796468, European Journal of Medicinal Chemistry, 2012, Liu, Jingbao et. al.
Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors
score: 1.5796147, Bioorganic & Medicinal Chemistry Letters, 2013, Morellato, Laurence et. al.
Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues
score: 1.5794343, Bioorganic & Medicinal Chemistry, 2004, Monga, Vikramdeep et. al.
Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors
score: 1.5793302, Bioorganic & Medicinal Chemistry, 2003, Chianelli, Dona et. al.
Bioisosteric replacement strategy for the synthesis of 1-azacyclic compounds with high affinity for the central nicotinic cholinergic receptors
score: 1.5793182, Bioorganic & Medicinal Chemistry, 2000, Olesen, Preben H. et. al.
Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimetics
score: 1.5792659, Bioorganic & Medicinal Chemistry Letters, 2010, Safavi, Maliheh et. al.
Synthesis and preliminary evaluation of some pyrazine containing thiazolines and thiazolidinones as antimicrobial agents
score: 1.5792456, Bioorganic & Medicinal Chemistry, 2004, Bonde, Chandrakant G.; Gaikwad, Naresh J.
New bisanthraquinone antibiotics and semi-synthetic derivatives with potent activity against clinical Staphylococcus aureus and Enterococcus faecium isolates
score: 1.5791205, Bioorganic & Medicinal Chemistry, 2006, Socha, Aaron M.; LaPlante, Kerry L.; Rowley, David C.
Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation
score: 1.5790141, European Journal of Medicinal Chemistry, 2012, Castro, Ma Angeles et. al.
Design and synthesis of releasable folate–drug conjugates using a novel heterobifunctional disulfide-containing linker
score: 1.5789344, Bioorganic & Medicinal Chemistry Letters, 2008, Satyam, Apparao
Origin of the stability conferred upon collagen by fluorination
score: 1.5788258, Bioorganic & Medicinal Chemistry Letters, 2009, Shoulders, Matthew D.; Kamer, Kimberli J.; Raines, Ronald T.
Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives and evaluation as antibacterials
score: 1.5787748, European Journal of Medicinal Chemistry, 2005, Kidwai, M. et. al.
Modulation of cofilin phosphorylation by inhibition of the Lim family kinases
score: 1.5786659, Bioorganic & Medicinal Chemistry Letters, 2012, He, Liqi et. al.
A metathetical cycloaddition–cycloreversion approach to the formation of furan scaffold libraries
score: 1.5785776, Bioorganic & Medicinal Chemistry, 1998, Whitehouse, Darren L. et. al.
Synthesis of imidazo[1,5,4- de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products
score: 1.5784609, Bioorganic & Medicinal Chemistry, 2005, LaBarbera, Daniel V.; Skibo, Edward B.
Synthesis and antitumor evaluation of novel Benzo[d]pyrrolo[2,1-b]thiazole derivatives
score: 1.5781279, European Journal of Medicinal Chemistry, 2012, Chaniyara, Ravi et. al.
Synthesis and antitumor evaluation of novel Benzo[d]pyrrolo[2,1-b]thiazole derivatives
score: 1.5781279, European Journal of Medicinal Chemistry, 2012, Chaniyara, Ravi et. al.
Molecular structure and biological and pharmacological properties of 3-hydroxy-2-methyl-1-(β-D-ribofuranosyl or pyranosyl)-4-pyridinone: potential iron overload drugs for oral administration
score: 1.5780907, Bioorganic & Medicinal Chemistry Letters, 1998, Liu, Gang et. al.
Properties and structure–activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I
score: 1.5776319, Bioorganic & Medicinal Chemistry, 2005, Robinson, John A. et. al.
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides
score: 1.5775768, Bioorganic & Medicinal Chemistry, 2012, Williams, John D. et. al.
Pyrazine-based Syk kinase inhibitors
score: 1.577558, Bioorganic & Medicinal Chemistry Letters, 2012, Forns, Pilar et. al.
Expedient synthesis of N- Z-pyroglutamyl-amino acid derivatives
score: 1.5775355, Bioorganic & Medicinal Chemistry Letters, 2007, Katritzky, Alan R. et. al.
Organometallic flavonoid derivatives as spectroscopic probes
score: 1.577529, Bioorganic & Medicinal Chemistry Letters, 1998, Anson, Christopher E. et. al.
Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2′,3′-dideoxy-2′,2′-difluoro-4′-azanucleosides
score: 1.5767884, Bioorganic & Medicinal Chemistry, 2012, Martínez-Montero, Saúl et. al.
Chemical modification of apomorphine to discover σ ligands: 6 H-dibenzo[ b, d]pyran and carbazole analogues
score: 1.5761636, Bioorganic & Medicinal Chemistry, 1999, Nakazato, Atsuro et. al.
Investigation of new potent KDO-8-phosphate synthetase inhibitors
score: 1.5760698, Bioorganic & Medicinal Chemistry Letters, 1999, Coutrot, Ph. et. al.
Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents
score: 1.5758212, Bioorganic & Medicinal Chemistry Letters, 2012, Tang, Xiaobo et. al.
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement
score: 1.575707, Bioorganic & Medicinal Chemistry Letters, 2012, Skidmore, John et. al.
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids
score: 1.5756245, Bioorganic & Medicinal Chemistry, 2009, Winum, Jean-Yves et. al.
Inhibition of protein kinase C by dequalinium analogues: Structure–activity studies on head group variations
score: 1.5755926, Bioorganic & Medicinal Chemistry, 2006, Abeywickrama, Chandima et. al.
Antitumor Agents. Part 214: † † For paper 213, see ref 1. Synthesis and Evaluation of Curcumin Analogues as Cytotoxic Agents
score: 1.5755526, Bioorganic & Medicinal Chemistry, 2002, Ishida, Junko et. al.
Traceless synthesis of benzimidazoles on solid support
score: 1.5754774, Bioorganic & Medicinal Chemistry Letters, 2000, Mazurov, Anatoly
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
score: 1.575356, European Journal of Medicinal Chemistry, 2012, Xia, Yan; Choi, Hyun-Kyung; Lee, Kyeong
Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity
score: 1.575261, Bioorganic & Medicinal Chemistry, 1999, Paz, Manuel M; Das, Arunangshu; Tomasz, Maria
Synthesis of novel GABA uptake inhibitors. part 6 † † See ref 1. : Preparation and evaluation of N-Ω asymmetrically substituted nipecotic acid derivatives
score: 1.5751643, Bioorganic & Medicinal Chemistry, 2001, Andersen, Knud Erik et. al.
Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: Discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype
score: 1.5750613, Bioorganic & Medicinal Chemistry Letters, 2012, Pothier, Julien et. al.
Remarkable G2/M phase arrest and apoptotic effect performed by 2-(6-aryl-3-hexen-1,5-diynyl) benzonitrile antitumor agents
score: 1.5750543, Bioorganic & Medicinal Chemistry, 2004, Lo, Yu-Hsiang; Lin, Chi-Fong; Hsieh, Ming-Chu; Wu, Ming-Jung
Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge
score: 1.575026, Bioorganic & Medicinal Chemistry Letters, 2012, He, Rui et. al.
Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge
score: 1.575026, Bioorganic & Medicinal Chemistry Letters, 2012, He, Rui et. al.
Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge
score: 1.575026, Bioorganic & Medicinal Chemistry Letters, 2012, He, Rui et. al.
Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge
score: 1.575026, Bioorganic & Medicinal Chemistry Letters, 2012, He, Rui et. al.
Solid-phase preparation of amides using N-acylbenzotriazoles
score: 1.5750132, Bioorganic & Medicinal Chemistry Letters, 2002, Katritzky, Alan R et. al.
Design and synthesis of novel platelet fibrinogen receptor antagonists with 2 H-1,4-benzoxazine-3(4 H)-one scaffold. A systematic study
score: 1.5749505, European Journal of Medicinal Chemistry, 2005, Anderluh, Marko et. al.
Synthesis and Biological Testing of Acyl-CoA–Ketoprofen Conjugates as Selective Irreversible Inhibitors of COX-2
score: 1.5749189, Bioorganic & Medicinal Chemistry, 2002, Levoin, Nicolas et. al.
Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro
score: 1.5746694, Bioorganic & Medicinal Chemistry, 2005, You, Youngjae et. al.
Synthesis of 2,6-difluoro-N-(3-[11C]methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide as a new potential PET agent for imaging of B-RafV600Ein cancers
score: 1.5744579, Bioorganic & Medicinal Chemistry Letters, 2013, Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Zheng, Qi-Huang
Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines
score: 1.5744079, European Journal of Medicinal Chemistry, 2006, Tiwari, Rakesh Kumar et. al.
Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation
score: 1.5743927, Bioorganic & Medicinal Chemistry Letters, 2001, Nagatsugi, Fumi et. al.
C 19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists
score: 1.5743356, Bioorganic & Medicinal Chemistry, 2006, Marwah, Padma et. al.
Novel chemical class of pUL97 protein kinase-specific inhibitors with strong anticytomegaloviral activity.
score: 1.574194, Antimicrobial agents and chemotherapy, 2004, Herget, Thomas et. al.
Additional bioactive annonaceous acetogenins from Asimina triloba (Annonaceae)
score: 1.5740173, Bioorganic & Medicinal Chemistry, 1997, He, Kan et. al.
Novel 4,4′-diether-2,2′-bipyridine cisplatin analogues are more effective than cisplatin at inducing apoptosis in cancer cell lines
score: 1.5738655, Bioorganic & Medicinal Chemistry, 2010, Vo, Van et. al.
New triazole derivatives as antifungal agents: Synthesis via click reaction, in vitro evaluation and molecular docking studies
score: 1.5738287, Bioorganic & Medicinal Chemistry Letters, 2012, Zou, Yan et. al.
Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: Discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype
score: 1.5738005, Bioorganic & Medicinal Chemistry Letters, 2012, Pothier, Julien et. al.
Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus
score: 1.5737062, Bioorganic & Medicinal Chemistry, 2012, Chiu, Hao-Chieh et. al.
Bicyclic Peptidomimetics Targeting Secreted Aspartic Protease 2 (SAP2) from Candida albicans Reveal a Constrained Inhibitory Chemotype
score: 1.5731968, Bioorganic & Medicinal Chemistry, 2012, Calugi, Chiara et. al.
Synthesis and biological activity of carbamate-linked cationic lipids for gene delivery in vitro
score: 1.5731833, Bioorganic & Medicinal Chemistry Letters, 2012, Zhi, Defu et. al.
Synthesis and biological activity of carbamate-linked cationic lipids for gene delivery in vitro
score: 1.5731833, Bioorganic & Medicinal Chemistry Letters, 2012, Zhi, Defu et. al.
Formation of the intermediate nitronyl nitroxide–anthracene dyad sensing saccharides
score: 1.5731826, Bioorganic & Medicinal Chemistry Letters, 2007, Yu, Yanxin et. al.
Conformationally constrained analogues of ( Z)-5-decenyl acetate, a pheromone component of Agrotis segetum
score: 1.5731515, Bioorganic & Medicinal Chemistry, 1996, Jönsson, Stig; Hansson, Bill S.; Liljefors, Tommy
An efficient synthesis of two monosulfated trisaccharides with the Galβ1,3GlcNAcβ1,3Galβ- O-Allyl backbone
score: 1.5731092, Bioorganic & Medicinal Chemistry Letters, 1999, Jie Xia, et. al.
An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1
score: 1.5727465, Bioorganic & Medicinal Chemistry Letters, 2012, Wilfong, Erin M; Du, Yu; Toone, Eric J.
Organometallic photonucleases: A novel class of DNA-cleaving agents
score: 1.5726925, Bioorganic & Medicinal Chemistry Letters, 1998, Mohler, Debra L et. al.
Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria
score: 1.5726716, Bioorganic & Medicinal Chemistry Letters, 2007, Ban, Shizuka et. al.
Microbial transformation of silybin by Trichoderma koningii
score: 1.5726303, Bioorganic & Medicinal Chemistry Letters, 2006, Kim, Hyun Jung; Park, Hae-Suk; Lee, Ik-Soo
An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a] pyrimidines derivatives
score: 1.5726092, Bioorganic & Medicinal Chemistry Letters, 2012, Chobe, Santosh S. et. al.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies
score: 1.5725847, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Efficient construction of 6-azasteroids: dual inhibitors of steroidal 5α-reductase
score: 1.5725334, Bioorganic & Medicinal Chemistry Letters, 1998, Sharp, Matthew J.; Fang, Francis G.
Synthesis and pharmacological evaluation of 4 H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels
score: 1.5725283, Bioorganic & Medicinal Chemistry, 2005, Schou, Søren C. et. al.
New cytosine derivatives as inhibitors of DNA methylation
score: 1.5725198, European Journal of Medicinal Chemistry, 2012, Plitta, Beata et. al.
Synthesis of Tropane and Nortropane Analogues with Phenyl Substitutions as Serotonin Transporter Ligands
score: 1.5725119, Bioorganic & Medicinal Chemistry, 2001, Emond, Patrick et. al.
Solid-phase synthesis of oligomeric deoxynucleic guanidine (DNG): A polycationic analogue of DNA
score: 1.5723748, Bioorganic & Medicinal Chemistry Letters, 1998, Linkletter, Barry A.; Bruice, Thomas C.
Structure–activity relationships of indole compounds derived from combretastatin A4: Synthesis and biological screening of 5-phenylpyrrolo[3,4- a]carbazole-1,3-diones as potential antivascular agents
score: 1.5722398, European Journal of Medicinal Chemistry, 2010, Ty, Nancy et. al.
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor
score: 1.5721139, Bioorganic & Medicinal Chemistry Letters, 2003, Kinoshita, Takayoshi et. al.
Electronic structure calculations on the thiazole-containing antibiotic thiostrepton: molecular mechanics, semi-empirical and ab initio analyses
score: 1.5720061, Bioorganic & Medicinal Chemistry Letters, 2005, Hang, Pei C.; Honek, John F.
Synthesis of 1-[3-(4-benzotriazol-1/2-yl-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-3-substituted-thiourea derivatives as antituberculosis agents
score: 1.5718496, European Journal of Medicinal Chemistry, 2006, Dixit, Prasad P. et. al.
Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents
score: 1.5716869, European Journal of Medicinal Chemistry, 2012, Sinha, Sarmistha Halder et. al.
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074
score: 1.5712771, Bioorganic & Medicinal Chemistry Letters, 2013, Suenkel, Benjamin; Fischer, Frank; Steegborn, Clemens
Design and synthesis of N-2,6-difluorophenyl-5-methoxyl-1,2,4-triazolo[1,5- a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor
score: 1.5712161, Bioorganic & Medicinal Chemistry, 2009, Chen, Chao-Nan et. al.
A new synthetic approach to 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives via a [2+2+2] cycloaddition reaction
score: 1.5712074, Bioorganic & Medicinal Chemistry Letters, 2000, Kotha, Sambasivarao; Sreenivasachary, Nampally
Synthesis and anti-tuberculosis activity of N-aryl- C-nitroazoles
score: 1.5711458, European Journal of Medicinal Chemistry, 2004, Walczak, Krzysztof; Gondela, Andrzej; Suwiński, Jerzy
Aplysia californica mediated cyclisation of novel 3′-modified NAD + analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5′-diphosphate ribose
score: 1.5711092, Bioorganic & Medicinal Chemistry, 2004, Mort, Christopher J.W et. al.
Hemi-synthesis and Biological Activity of New Analogues of Podophyllotoxin
score: 1.5705175, Bioorganic & Medicinal Chemistry, 2002, Roulland, Emmanuel et. al.
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/ vascular adhesion protein-1 (SSAO/VAP-1)
score: 1.5704606, Bioorganic & Medicinal Chemistry Letters, 2012, Foot, Jonathan S. et. al.
Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1-dependent transcription
score: 1.5700263, European Journal of Medicinal Chemistry, 2012, Osorio, Alex A. et. al.
Structure–activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia–reperfusion injury
score: 1.5698547, Bioorganic & Medicinal Chemistry, 2006, Kálai, Tamás et. al.
Coumarin, chromone, and 4(3 H)-pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis
score: 1.5698436, Bioorganic & Medicinal Chemistry, 2003, Roma, Giorgio et. al.
Design, synthesis and evaluation of d-galactose-β-cyclodextrin conjugates as drug-carrying molecules
score: 1.5698137, Bioorganic & Medicinal Chemistry, 2008, Oda, Yoshiki et. al.
Synthesis of 5-(2-amino-2-deoxy-β- d-glucopyranosyloxymethyl)-2′-deoxyuridine and its incorporation into oligothymidylates
score: 1.5697823, Bioorganic & Medicinal Chemistry Letters, 1999, Hunziker, Jürg
From nature to the laboratory and into the clinic
score: 1.5697576, Bioorganic & Medicinal Chemistry, 2009, Nicolaou, K.C.; Chen, Jason S.; Dalby, Stephen M.
Synthesis and structure of chiral macrocycles containing 2,2′-bipyridine subunits
score: 1.5696891, Bioorganic & Medicinal Chemistry, 1996, Hopkins, R.Bruce et. al.
Fluorometric Detection of Adenine in Target DNA by Exciplex Formation with Fluorescent 8-Arylethynylated Deoxyguanosine
score: 1.5696154, Bioorganic & Medicinal Chemistry Letters, 2012, Saito, Yoshio et. al.
Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives
score: 1.5692041, European Journal of Medicinal Chemistry, 2012, Wang, Shi-Ben et. al.
Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives
score: 1.5692041, European Journal of Medicinal Chemistry, 2012, Wang, Shi-Ben et. al.
Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity.
score: 1.5691646, Antimicrobial agents and chemotherapy, 2002, Koo, Hyun et. al.
Synthesis of 4β-amido and 4β-sulphonamido analogues of podophyllotoxin as potential antitumour agents
score: 1.5691058, Bioorganic & Medicinal Chemistry, 2003, Kamal, Ahmed et. al.
Application of (quantitative) structure–activity relationships to progestagens: from serendipity to structure-based design
score: 1.5685826, European Journal of Medicinal Chemistry, 2000, Bursi, Roberta; Groen, Marinus B
New CD1d agonists: Synthesis and biological activity of 6′′-triazole-substituted α-galactosyl ceramides
score: 1.5685163, Bioorganic & Medicinal Chemistry Letters, 2012, Jervis, Peter J. et. al.
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents
score: 1.5685132, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ting et. al.
Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E 2
score: 1.5683595, Bioorganic & Medicinal Chemistry, 2006, Reyes, Carolina P. et. al.
Non-classical antifolates, 5-( N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5 H)-oxopyrimidines, synthesis and antitumor studies
score: 1.5683078, Bioorganic & Medicinal Chemistry, 2003, Huang, Yen-Lin et. al.
Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles
score: 1.5681773, Bioorganic & Medicinal Chemistry, 2006, Castro, Ana et. al.
Synthesis and characterization of several carbamoyl- and methylcarbamoyl-substituted EMPO derivatives
score: 1.568169, Bioorganic & Medicinal Chemistry, 2009, Stolze, Klaus et. al.
Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex
score: 1.56812, Bioorganic & Medicinal Chemistry, 1997, Taveras, A.G. et. al.
Quantitative structure–activity analysis of 5-arylidene-2,4-thiazolidinediones as aldose reductase inhibitors
score: 1.5680315, Bioorganic & Medicinal Chemistry Letters, 2006, Sambasivarao, S.V. et. al.
Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants
score: 1.5679849, Bioorganic & Medicinal Chemistry, 2012, Kimura, Ken-ichi et. al.
Bile acid derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibition effects
score: 1.5679627, Bioorganic & Medicinal Chemistry, 2002, Bülbül, Metin et. al.
Molecular basis for cis-urocanic acid as a 5-HT 2A receptor agonist
score: 1.5676732, Bioorganic & Medicinal Chemistry Letters, 2009, Shen, Liang; Ji, Hong-Fang
Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles
score: 1.5675154, Bioorganic & Medicinal Chemistry, 2006, Ramla, Mostafa M. et. al.
New technique for high-throughput synthesis
score: 1.567419, Bioorganic & Medicinal Chemistry Letters, 1999, Lebl, Michal
Tetrahydroacridin-9-ones, 9-chlorotetrahydroacridines, 9-amino-tetrahydroacridines and 9-(pyrazol-1-yl)-tetrahydroacridines derived from chiral cyclanones
score: 1.5673678, European Journal of Medicinal Chemistry, 2004, Frideling, Aline et. al.
Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure
score: 1.5670524, Bioorganic & Medicinal Chemistry, 2009, Fujii, Shinya et. al.
RETRACTED: A computational docking study for prediction of binding mode of diospyrin and derivatives: Inhibitors of human and leishmanial DNA topoisomerase-I
score: 1.5670394, Bioorganic & Medicinal Chemistry Letters, 2007, Chhabra, Sandeep; Sharma, Pooja; Ghoshal, Nanda
Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives
score: 1.5669535, European Journal of Medicinal Chemistry, 2012, Shulaeva, M.M. et. al.
Histidine kinases as targets for new antimicrobial agents
score: 1.5668385, Bioorganic & Medicinal Chemistry, 2002, Matsushita, Masayuki; Janda, Kim D.
Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms.
score: 1.5667581, Antimicrobial agents and chemotherapy, 2012, D'Costa, Vanessa M et. al.
Synthesis of silicon-containing azole derivatives with magnesium bromide diethyl etherate, and an investigation of their fungicidal activities
score: 1.5664787, Bioorganic & Medicinal Chemistry, 2002, Itoh, Hiroyuki et. al.
Solid-phase synthesis of a library of piperazinediones and diazepinediones via kaiser oxime resin
score: 1.5663028, Bioorganic & Medicinal Chemistry Letters, 1998, Smith, Roger A.; Bobko, Mark A.; Lee, Wendy
Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling
score: 1.5662263, European Journal of Medicinal Chemistry, 2012, Rubio, Sara et. al.
MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic Clostridium difficile.
score: 1.5661718, Antimicrobial agents and chemotherapy, 2012, Butler, Michelle M et. al.
A New Method for Chemoselective Conjugation of Unprotected Peptides to Dauno- and Doxorubicin
score: 1.5661712, Bioorganic & Medicinal Chemistry Letters, 2001, Ingallinella, Paolo et. al.
Self-organizing molecular field analysis of 2,4-thiazolidinediones: A 3D-QSAR model for the development of human PTP1B inhibitors
score: 1.5659966, European Journal of Medicinal Chemistry, 2010, Thareja, Suresh et. al.
Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines
score: 1.5657088, European Journal of Medicinal Chemistry, 2012, Verma, Vikas et. al.
Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines
score: 1.5657088, European Journal of Medicinal Chemistry, 2012, Verma, Vikas et. al.
DNA photocleavage and biological activity of a pyrene dihydrodioxin
score: 1.5656341, Bioorganic & Medicinal Chemistry Letters, 2005, Mack, Eric T. et. al.
Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1)
score: 1.5656237, Bioorganic & Medicinal Chemistry, 2006, Mavel, Sylvie et. al.
Synthesis and binding affinities of fluoroalkylated raloxifenes
score: 1.5655244, Bioorganic & Medicinal Chemistry, 2003, Lee, Kyo Chul et. al.
Resolution, molecular structure and biological activities of the d- and l-enantiomers of potent anti-implantation agent, dl-2-[4-(2-Piperidinoethoxy)phenyl]-3-phenyl-2 H-1-benzopyran
score: 1.5654416, Bioorganic & Medicinal Chemistry, 1999, Hajela, K. et. al.
Synthesis and anti-norovirus activity of pyranobenzopyrone compounds
score: 1.5652691, Bioorganic & Medicinal Chemistry Letters, 2012, Pokhrel, Laxman et. al.
Synthesis and anti-norovirus activity of pyranobenzopyrone compounds
score: 1.5652691, Bioorganic & Medicinal Chemistry Letters, 2012, Pokhrel, Laxman et. al.
Discovery and structure–activity analysis of selective estrogen receptor modulators via similarity-based virtual screening
score: 1.5651115, European Journal of Medicinal Chemistry, 2012, Shen, Jie et. al.
Discovery and structure–activity analysis of selective estrogen receptor modulators via similarity-based virtual screening
score: 1.5651115, European Journal of Medicinal Chemistry, 2012, Shen, Jie et. al.
Design and synthesis of HIV-1 protease inhibitors. Novel tetrahydrofuran P2/P2′-groups interacting with Asp29/30 of the HIV-1 protease. Determination of binding from X-ray crystal structure of inhibitor protease complex
score: 1.5650842, Bioorganic & Medicinal Chemistry, 2003, Oscarsson, Karin et. al.
Synthesis and In Vitro Antitumor Activity of Thiophene Analogues of 5-Chloro-5,8-dideazafolic Acid and 2-Methyl-2-desamino-5-chloro-5,8-dideazafolic Acid
score: 1.5650226, Bioorganic & Medicinal Chemistry, 2002, Forsch, Ronald A.; Wright, Joel E.; Rosowsky, Andre
Design and synthesis of reagents for phage display screening of dehalogenases
score: 1.5646412, Bioorganic & Medicinal Chemistry Letters, 1999, Pieters, Roland J et. al.
Microwave assisted synthesis of unsaturated jasmone heterocyclic analogues as new fragrant substances
score: 1.564558, European Journal of Medicinal Chemistry, 2009, Pawełczyk, Anna; Zaprutko, Lucjusz
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
score: 1.5643787, Antimicrobial agents and chemotherapy, 2005, Ferris, Robert G et. al.
Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides
score: 1.5642963, Bioorganic & Medicinal Chemistry, 2005, Cheng, Ming-Jen et. al.
Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4 H-thieno[2,3- d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3 H-thieno[2,3- d]pyrimidin-4-ones as antimicrobial agents
score: 1.5638697, European Journal of Medicinal Chemistry, 2003, Chambhare, Ravindra V et. al.
Orally active fusion inhibitor of respiratory syncytial virus.
score: 1.5630745, Antimicrobial agents and chemotherapy, 2004, Cianci, Christopher et. al.
Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives
score: 1.5630458, European Journal of Medicinal Chemistry, 2012, Raimondi, Maria Valeria et. al.
Synthesis and photodynamic properties of adamantylethoxy Zn(II) phthalocyanine derivatives in different media and in human red blood cells
score: 1.5626626, European Journal of Medicinal Chemistry, 2012, Ochoa, A. Laura et. al.
Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures
score: 1.562637, Bioorganic & Medicinal Chemistry Letters, 2012, Bigioni, Mario et. al.
Convergent synthesis of an inner core GPI of sperm CD52
score: 1.5625614, Bioorganic & Medicinal Chemistry Letters, 2002, Xue, Jie; Guo, Zhongwu
Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A2 activity
score: 1.5622598, Bioorganic & Medicinal Chemistry, 2012, Pedersen, Palle J. et. al.
Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A2 activity
score: 1.5622598, Bioorganic & Medicinal Chemistry, 2012, Pedersen, Palle J. et. al.
The role of hydrophobic properties of chemicals in promoting allosteric reactions
score: 1.562164, Bioorganic & Medicinal Chemistry, 2005, Mekapati, Suresh B. et. al.
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels−Alder reaction
score: 1.5621272, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng et. al.
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels−Alder reaction
score: 1.5621272, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng et. al.
TOPS-MODE based QSARs derived from heterogeneous series of compounds. Applications to the design of new anti-inflammatory compounds
score: 1.5617172, Bioorganic & Medicinal Chemistry, 2004, Pérez González, Maykel et. al.
New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure–activity relationships
score: 1.5616714, European Journal of Medicinal Chemistry, 2012, Areias, Filipe et. al.
Using a kinase screen to investigate the constituents of the sponge Stelletta clavosa obtained from diverse habitats
score: 1.5613351, Bioorganic & Medicinal Chemistry, 2004, Wegerski, Christopher J. et. al.
Synthesis of fluorescent C 24-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin
score: 1.5611617, Bioorganic & Medicinal Chemistry Letters, 2009, Novotný, Jakub et. al.
Synthesis and application of photoaffinity probe containing an intact isoprenoid chain
score: 1.5609871, Bioorganic & Medicinal Chemistry Letters, 2009, Li, Lingdong; Tang, Wei; Zhao, Zongbao Kent
Synthesis and β-amyloid binding properties of rhenium 2-phenylbenzothiazoles
score: 1.5609226, Bioorganic & Medicinal Chemistry Letters, 2009, Lin, Kuo-Shyan et. al.
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
score: 1.5607933, Bioorganic & Medicinal Chemistry Letters, 2012, Mandadapu, Sivakoteswara Rao et. al.
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
score: 1.5607933, Bioorganic & Medicinal Chemistry Letters, 2012, Mandadapu, Sivakoteswara Rao et. al.
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
score: 1.5607933, Bioorganic & Medicinal Chemistry Letters, 2012, Mandadapu, Sivakoteswara Rao et. al.
Design, synthesis and evaluation of naphthalene-2-carboxamides as reversal agents in MDR cancer
score: 1.5607827, Bioorganic & Medicinal Chemistry, 2006, Lokhande, Tushar N. et. al.
Macromolecular recognition: Effect of multivalency in the inhibition of binding of yeast mannan to concanavalin A and pea lectins by mannosylated dendrimers
score: 1.5606716, Bioorganic & Medicinal Chemistry, 1996, Pagé, Daniel; Zanini, Diana; Roy, René
Synthesis and characterization of the Zn(II) and Cu(II) piperidinyl isoeuxanthone complexes: DNA-binding and cytotoxic activity
score: 1.5605626, European Journal of Medicinal Chemistry, 2009, Wang, Hui-Fang; Shen, Rui; Tang, Ning
A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space
score: 1.5600937, Journal of Cheminformatics, 2012, Singh, Narender et. al.
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its Replacement by a pyridinone ring Produces Intriguing differences in cytocidal activity
score: 1.559989, European Journal of Medicinal Chemistry, 2012, Masurier, Nicolas et. al.
Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells
score: 1.559877, European Journal of Medicinal Chemistry, 2003, Alibert, Sandrine et. al.
Alkyl gallates, intensifiers of beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus.
score: 1.5598207, Antimicrobial agents and chemotherapy, 2005, Shibata, Hirofumi et. al.
Connecting traditional QSAR and molecular simulations of papain hydrolysis—importance of charge transfer
score: 1.5597774, Bioorganic & Medicinal Chemistry, 2005, Lepp, Zsolt; Chuman, Hiroshi
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
score: 1.5597677, Bioorganic & Medicinal Chemistry Letters, 2012, Tamboli, Yasinalli et. al.
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid
score: 1.5596853, Bioorganic & Medicinal Chemistry Letters, 2012, Persch, Elke et. al.
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid
score: 1.5596853, Bioorganic & Medicinal Chemistry Letters, 2012, Persch, Elke et. al.
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid
score: 1.5596853, Bioorganic & Medicinal Chemistry Letters, 2012, Persch, Elke et. al.
Design and synthesis of an irreversible dopamine-sparing cocaine antagonist
score: 1.5596043, Bioorganic & Medicinal Chemistry, 2002, Meltzer, Peter C. et. al.
Penicacids A–C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07
score: 1.5594934, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Ziming et. al.
Penicacids A–C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07
score: 1.5594934, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Ziming et. al.
Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents
score: 1.5594362, European Journal of Medicinal Chemistry, 2012, Liu, Xin-Hua et. al.
Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.
score: 1.5594141, Antimicrobial agents and chemotherapy, 2000, Kotra, L P; Haddad, J; Mobashery, S
Natural products as a gold mine for selective matrix metalloproteinases inhibitors
score: 1.5593567, Bioorganic & Medicinal Chemistry, 2012, Wang, Liyan et. al.
Natural products as a gold mine for selective matrix metalloproteinases inhibitors
score: 1.5593567, Bioorganic & Medicinal Chemistry, 2012, Wang, Liyan et. al.
Natural products as a gold mine for selective matrix metalloproteinases inhibitors
score: 1.5593567, Bioorganic & Medicinal Chemistry, 2012, Wang, Liyan et. al.
Synthesis of quinoline derivatives for fluorescent imaging certain bacteria
score: 1.5591403, Bioorganic & Medicinal Chemistry Letters, 2012, Dhanapal, Ramu et. al.
Comparison of the Inhibition of Human and Trypanosoma cruzi Prolyl Endopeptidases
score: 1.5590201, Bioorganic & Medicinal Chemistry, 2002, Vendeville, Sandrine et. al.
Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives
score: 1.5587317, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Zhenhua et. al.
Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives
score: 1.5587317, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Zhenhua et. al.
2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer’s disease
score: 1.5584834, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Jiamin et. al.
2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer’s disease
score: 1.5584834, Bioorganic & Medicinal Chemistry Letters, 2012, Gu, Jiamin et. al.
Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.
score: 1.5579884, Antimicrobial agents and chemotherapy, 2008, Black, Michael T et. al.
Synthesis and properties of chiral peptide nucleic acids with a N-Aminoethyl- d-proline backbone
score: 1.5579506, Bioorganic & Medicinal Chemistry Letters, 2000, Vilaivan, Tirayut et. al.
Stereochemistry of the reduction of 24-ethyldesmosterol to sitosterol in tissue cultures of Oryza sativa
score: 1.5579086, Bioorganic & Medicinal Chemistry Letters, 1998, Fujimoto, Yoshinori et. al.
Design, synthesis and bioactivities of TAR RNA targeting β-carboline derivatives based on Tat–TAR interaction
score: 1.5578025, European Journal of Medicinal Chemistry, 2005, Yu, Xiaolin; Lin, Wei; Pang, Ruifang; Yang, Ming
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): A search for new dual-acting agents as potential antidepressants
score: 1.5576539, European Journal of Medicinal Chemistry, 2012, Zhu, Xue Y. et. al.
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): A search for new dual-acting agents as potential antidepressants
score: 1.5576539, European Journal of Medicinal Chemistry, 2012, Zhu, Xue Y. et. al.
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): A search for new dual-acting agents as potential antidepressants
score: 1.5576539, European Journal of Medicinal Chemistry, 2012, Zhu, Xue Y. et. al.
Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants
score: 1.5575378, Bioorganic & Medicinal Chemistry, 2012, Kimura, Ken-ichi et. al.
Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants
score: 1.5575378, Bioorganic & Medicinal Chemistry, 2012, Kimura, Ken-ichi et. al.
Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants
score: 1.5575378, Bioorganic & Medicinal Chemistry, 2012, Kimura, Ken-ichi et. al.
Inhibition of the R1 fragment of the cadmium-containing ζ-class carbonic anhydrase from the diatom Thalassiosira weissflogii with anions
score: 1.557529, Bioorganic & Medicinal Chemistry Letters, 2010, Viparelli, Francesca et. al.
Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines
score: 1.5574174, Bioorganic & Medicinal Chemistry Letters, 2012, Murthy, Y.L.N. et. al.
Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines
score: 1.5574174, Bioorganic & Medicinal Chemistry Letters, 2012, Murthy, Y.L.N. et. al.
New Taxol ® (paclitaxel) prodrugs designed for ADEPT and PMT strategies in cancer chemotherapy
score: 1.557232, Bioorganic & Medicinal Chemistry, 2006, Alaoui, Abdessamad El et. al.
A novel series of orally active antiplatelet agents
score: 1.5571839, Bioorganic & Medicinal Chemistry, 1995, Zablocki, Jeffery A. et. al.
Novel imidazo[1,2- c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation
score: 1.5571015, Bioorganic & Medicinal Chemistry, 2004, Kifli, Nurolaini et. al.
Clofazimine analogs with efficacy against experimental tuberculosis and reduced potential for accumulation.
score: 1.5569861, Antimicrobial agents and chemotherapy, 2011, Lu, Yu et. al.
Stereoselective syntheses of substituted pterocarpans with anti-HIV activity, and 5-aza-/5-thia-pterocarpan and 2-aryl-2,3-dihydrobenzofuran analogues
score: 1.5569177, Bioorganic & Medicinal Chemistry, 1996, Engler, Thomas A. et. al.
3-D-QSAR CoMFA and CoMSIA studies on tetrahydrofuroyl- l-phenylalanine derivatives as VLA-4 antagonists
score: 1.5567459, Bioorganic & Medicinal Chemistry, 2003, Khandelwal, Akash et. al.
Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants
score: 1.5566766, Bioorganic & Medicinal Chemistry, 2012, Duskova, Katerina et. al.
Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants
score: 1.5566766, Bioorganic & Medicinal Chemistry, 2012, Duskova, Katerina et. al.
Combined Fmoc-Alloc strategy for a general SPPS of phosphoserine peptides; preparation of phosphorylation-dependent tau antisera
score: 1.5566403, Bioorganic & Medicinal Chemistry, 1997, Shapiro, Gideon et. al.
A new approach for modification of phenylalanine peptides by suzuki–miyaura coupling reaction
score: 1.5566012, Bioorganic & Medicinal Chemistry Letters, 2001, Kotha, Sambasivarao; Lahiri, Kakali
Synthesis of 3-alkyl(Aryl)-4-alkylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones and 3-alkyl-4-alkylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones as antitumor agents
score: 1.5565438, Bioorganic & Medicinal Chemistry, 2002, Demirbaş, Neslihan; Ug̵urluog̵lu, Reyhan; Demirbaş, Ahmet
Recent advances in the synthesis of raloxifene: A selective estrogen receptor modulator
score: 1.5564395, European Journal of Medicinal Chemistry, 2012, Dadiboyena, Sureshbabu
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist
score: 1.5564045, European Journal of Medicinal Chemistry, 2012, Fumagalli, Laura et. al.
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist
score: 1.5564045, European Journal of Medicinal Chemistry, 2012, Fumagalli, Laura et. al.
Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases.
score: 1.5562802, Antimicrobial agents and chemotherapy, 1998, Massova, I; Mobashery, S
Modeling of farnesyltransferase inhibition by some thiol and non-thiol peptidomimetic inhibitors using genetic neural networks and RDF approaches
score: 1.5562466, Bioorganic & Medicinal Chemistry, 2006, González, Maykel Pérez et. al.
A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro.
score: 1.5561517, Antimicrobial agents and chemotherapy, 2010, Kaptein, Suzanne J F et. al.
Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II
score: 1.5558176, Bioorganic & Medicinal Chemistry, 2012, Obniska, Jolanta; Rzepka, Sabina; Kamiński, Krzysztof
Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II
score: 1.5558176, Bioorganic & Medicinal Chemistry, 2012, Obniska, Jolanta; Rzepka, Sabina; Kamiński, Krzysztof
Selected chromone derivatives as inhibitors of monoamine oxidase
score: 1.5557892, Bioorganic & Medicinal Chemistry Letters, 2012, Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P.
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
score: 1.5554475, Bioorganic & Medicinal Chemistry, 2012, Okaecwe, Thokozile et. al.
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
score: 1.5554475, Bioorganic & Medicinal Chemistry, 2012, Okaecwe, Thokozile et. al.
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
score: 1.5554475, Bioorganic & Medicinal Chemistry, 2012, Okaecwe, Thokozile et. al.
Controlled release of DNA/polyamine complex by photoirradiation of a solid phase presenting o-nitrobenzyl ether tethered spermine or polyethyleneimine
score: 1.5553311, Bioorganic & Medicinal Chemistry Letters, 2006, Kim, Moon Suk; Diamond, Scott L.
Novel synthesis and in vitro drug release of polymeric prodrug: Chitosan– O-isopropyl-5′- O-d4T monophosphate conjugate
score: 1.5553213, Bioorganic & Medicinal Chemistry Letters, 2009, Yang, Lin et. al.
Synthesis and evaluation of 9-anilinothiazolo[5,4-b]quinoline derivatives as potential antitumorals
score: 1.5550391, European Journal of Medicinal Chemistry, 2004, Rodríguez-Loaiza, Pilar et. al.
Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes
score: 1.5549667, Bioorganic & Medicinal Chemistry Letters, 2007, Verdoes, Martijn et. al.
Tumor chemopreventive activity of 3- O-acylated (−)-epigallocatechins
score: 1.5548932, Bioorganic & Medicinal Chemistry, 2003, Kumagai, Ayako et. al.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies
score: 1.5547197, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies
score: 1.5547197, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies
score: 1.5547197, Bioorganic & Medicinal Chemistry Letters, 2012, Fujii, Hideaki et. al.
Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors
score: 1.5547115, Bioorganic & Medicinal Chemistry, 1999, Qian, Yimin et. al.
A physically interpretable quantum-theoretic QSAR for some carbonic anhydrase inhibitors with diverse aromatic rings, obtained by a new QSAR procedure
score: 1.5539644, Bioorganic & Medicinal Chemistry, 2005, Clare, Brian W.; Supuran, Claudiu T.
Enhancement of fluorescence quenching and exciplex formation in DNA major groove by double incorporation of modified fluorescent deoxyuridines
score: 1.5539573, Bioorganic & Medicinal Chemistry Letters, 2012, Tanaka, Makiko; Oguma, Kazuhiro; Saito, Yoshio; Saito, Isao
Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold
score: 1.5539339, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tiehai et. al.
Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold
score: 1.5539339, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Tiehai et. al.
Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
score: 1.5538362, Bioorganic & Medicinal Chemistry, 2001, Groutas, William C et. al.
Optimization of Thiazole Analogues of Resveratrol for Induction of NAD(P)H:quinone Reductase 1 (QR1)
score: 1.5536617, Bioorganic & Medicinal Chemistry, 2012, Mayhoub, Abdelrahman S. et. al.
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity
score: 1.5535421, Bioorganic & Medicinal Chemistry Letters, 2012, Surivet, Jean-Philippe et. al.
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity
score: 1.5535421, Bioorganic & Medicinal Chemistry Letters, 2012, Surivet, Jean-Philippe et. al.
Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides
score: 1.5533728, Bioorganic & Medicinal Chemistry Letters, 2006, Kurata, Christine et. al.
Synthesis and acrosin inhibitory activity of methyl 5–substituted-1H-benzo[d]imidazol–2-yl carbamate derivatives
score: 1.5532861, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Xuefei et. al.
Molecular recognition of 15-deoxy-Δ 12,14-prostaglandin J 2 by nuclear factor-kappa B and other cellular proteins
score: 1.5532623, Bioorganic & Medicinal Chemistry Letters, 2005, Pande, Vineet; Ramos, Maria J.
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics
score: 1.5530011, Bioorganic & Medicinal Chemistry, 2012, Clinch, Keith et. al.
2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR
score: 1.5524925, Bioorganic & Medicinal Chemistry Letters, 2005, Wyatt, Paul G. et. al.
Synthesis and inhibitory effect of piperine derivates on monoamine oxidase
score: 1.5521723, Bioorganic & Medicinal Chemistry Letters, 2012, Mu, Li-Hua et. al.
Synthesis and inhibitory effect of piperine derivates on monoamine oxidase
score: 1.5521723, Bioorganic & Medicinal Chemistry Letters, 2012, Mu, Li-Hua et. al.
Insights into MAPK p 38 α DFG flip mechanism by accelerated molecular dynamics
score: 1.5521563, Bioorganic & Medicinal Chemistry, 2010, Filomia, Federico et. al.
Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines
score: 1.5519662, Bioorganic & Medicinal Chemistry Letters, 2007, Lo, Pui-Chi et. al.
Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity
score: 1.5519283, Bioorganic & Medicinal Chemistry Letters, 2003, Ortmann, Regina et. al.
99mTc-tricarbonyl labeled agents for cell labeling: Development, biodistribution in normal mice and preliminary in vitro evaluation
score: 1.5517447, Bioorganic & Medicinal Chemistry, 2010, Fonge, Humphrey et. al.
Synthesis, cytotoxicity, QSAR, and intercalation study of new diindenopyridine derivatives
score: 1.5516712, Bioorganic & Medicinal Chemistry, 2004, Miri, Ramin et. al.
RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues
score: 1.5512901, Bioorganic & Medicinal Chemistry, 2009, Zhang, Nan et. al.
D-ring substituted rhazinilam analogues: semisynthesis and evaluation of antitubulin activity
score: 1.5512849, Bioorganic & Medicinal Chemistry, 1999, Dupont, Christophe et. al.
Human telomerase inhibition and cytotoxicity of regioisomeric disubstituted amidoanthraquinones and aminoanthraquinones
score: 1.5511285, Bioorganic & Medicinal Chemistry, 2005, Huang, Hsu-Shan et. al.
Synthesis of Potential Thrombin Inhibitors. Incorporation of Tartaric Acid Templates as P2 Proline Mimetics
score: 1.551112, Bioorganic & Medicinal Chemistry, 2002, Dahlgren, Anders et. al.
Synthesis and antiamoebic activities of 1- N-substituted cyclised pyrazoline analogues of thiosemicarbazones
score: 1.5511116, Bioorganic & Medicinal Chemistry, 2005, Abid, Mohammad; Azam, Amir
High affinity and selectivity of [[(arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives for the 5-HT 1A receptor.Synthesis and structure–affinity relationships
score: 1.5510997, European Journal of Medicinal Chemistry, 2000, Modica, Maria et. al.
Synthesis and evaluation of new arylsulfonamidomethylcyclohexyl derivatives as human neuropeptide Y Y 5 receptor antagonists for the treatment of obesity
score: 1.550829, European Journal of Medicinal Chemistry, 2004, Moreno, Antonio et. al.
Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues
score: 1.5504412, Bioorganic & Medicinal Chemistry, 2005, Jain, Meenakshi et. al.
The solution structures of calyculin A and dephosphonocalyculin A by NMR
score: 1.5502807, Bioorganic & Medicinal Chemistry Letters, 1999, Volter, Katie E. et. al.
Solid phase synthesis of 2-aminobenzothiazoles
score: 1.5502661, Bioorganic & Medicinal Chemistry Letters, 2010, Piscitelli, Francesco; Ballatore, Carlo; Smith, Amos B.
Synthesis and insecticidal evaluation of novel N-pyridylpyrazolecarboxamides containing cyano substituent in the ortho-position
score: 1.549772, Bioorganic & Medicinal Chemistry Letters, 2013, Mao, Mingzhen et. al.
Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues
score: 1.5497069, Bioorganic & Medicinal Chemistry, 2001, LeTiran, Arnaud; Stables, James P; Kohn, Harold
A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil.
score: 1.5496506, Antimicrobial agents and chemotherapy, 2000, Bonnet, R et. al.
Synthesis and antiproliferative activities ofN-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives
score: 1.5496389, European Journal of Medicinal Chemistry, 2013, Chen, I-Li et. al.
Synthesis and antiproliferative activities of N-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives
score: 1.5496389, European Journal of Medicinal Chemistry, 2013, Chen, I-Li et. al.
Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes
score: 1.5495663, Bioorganic & Medicinal Chemistry Letters, 2012, Mack, Daniel J. et. al.
Isoflavones inhibit the clonogenicity of human colon cancer cells
score: 1.5494584, Bioorganic & Medicinal Chemistry Letters, 2012, Hyun, Jiye et. al.
Isoflavones inhibit the clonogenicity of human colon cancer cells
score: 1.5494584, Bioorganic & Medicinal Chemistry Letters, 2012, Hyun, Jiye et. al.
4,5,9,10-Tetrahydro-1,4-ethanobenz[ b]quinolizine as a prodrug for its quinolizinium cation as a ligand to the open state of the TCP-binding site of NMDA receptors
score: 1.5492808, Bioorganic & Medicinal Chemistry Letters, 2001, Sasaki, Shigeki et. al.
Mutation in Serratia marcescens AmpC beta-lactamase producing high-level resistance to ceftazidime and cefpirome.
score: 1.5492729, Antimicrobial agents and chemotherapy, 2001, Raimondi, A; Sisto, F; Nikaido, H
Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus
score: 1.549194, Bioorganic & Medicinal Chemistry, 2012, Chiu, Hao-Chieh et. al.
Highly-Iodinated Fullerene as a Contrast Agent For X-ray Imaging
score: 1.5490992, Bioorganic & Medicinal Chemistry, 2002, Wharton, Tim; Wilson, Lon J.
Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives
score: 1.5489387, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Zhenhua et. al.
Solid phase synthesis of acylglycine human metabolites
score: 1.5486406, Bioorganic & Medicinal Chemistry Letters, 2009, Perez-Pineiro, Rolando; Dong, Ying Wei; Wishart, David S.
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.
score: 1.5485606, Antimicrobial agents and chemotherapy, 2004, Ruzin, Alexey et. al.
Synthesis of novel brassinosteroid biosynthesis inhibitors based on the ketoconazole scaffold
score: 1.5484819, Bioorganic & Medicinal Chemistry Letters, 2012, Oh, Keimei; Yamada, Kazuhiro; Asami, Tadao; Yoshizawa, Yuko
Synthesis and structure–activity relationship studies of 4,11-diaminonaphtho[2,3- f]indole-5,10-diones
score: 1.5481179, Bioorganic & Medicinal Chemistry, 2006, Shchekotikhin, Andrey E. et. al.
Synthesis and Evaluation of in Vitro Bioactivity for Vesicular Acetylcholine Transporter Inhibitors Containing Two Carbonyl Groups
score: 1.547851, Bioorganic & Medicinal Chemistry, 2012, Tu, Zhude et. al.
Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors
score: 1.5476119, Bioorganic & Medicinal Chemistry, 1998, Boger, Dale L et. al.
Novel dithiocarbamate carbapenems with anti-MRSA activity
score: 1.5474491, Bioorganic & Medicinal Chemistry, 1998, Ohtake, Norikazu et. al.
New CD1d Agonists: Synthesis and Biological Activity of 6”-Triazole-Substituted α-Galactosyl Ceramides
score: 1.5473455, Bioorganic & Medicinal Chemistry Letters, 2012, Jervis, Peter J. et. al.
Use of the X-ray structure of the Beta2-adrenergic receptor for drug discovery
score: 1.5471713, Bioorganic & Medicinal Chemistry Letters, 2008, Topiol, Sid; Sabio, Michael
Oligosaccharides as inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues
score: 1.5471664, Bioorganic & Medicinal Chemistry, 2005, Cociorva, Oana M. et. al.
An efficient synthesis of 3-OBn-6β,14-epoxy-bridged opiates from naltrexone and identification of a related dual MOR inverse agonist/KOR agonist
score: 1.5469257, Bioorganic & Medicinal Chemistry Letters, 2012, Martin, David J. et. al.
An efficient synthesis of 3-OBn-6β,14-epoxy-bridged opiates from naltrexone and identification of a related dual MOR inverse agonist/KOR agonist
score: 1.5469257, Bioorganic & Medicinal Chemistry Letters, 2012, Martin, David J. et. al.
Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)
score: 1.5468428, Bioorganic & Medicinal Chemistry Letters, 2012, Seal, Jonathan et. al.
Selenazolidines as Novel Organoselenium Delivery Agents
score: 1.5467693, Bioorganic & Medicinal Chemistry Letters, 2001, Xie, Yang et. al.
Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11 H-indeno-[1,2- b]-quinolin-10-ylamine derivatives
score: 1.5466713, Bioorganic & Medicinal Chemistry, 2000, Rampa, Angela et. al.
Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives
score: 1.5465102, Bioorganic & Medicinal Chemistry Letters, 2012, Pathak, Ravindra B.; Chovatia, P.T.; Parekh, H.H.
Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives
score: 1.5465102, Bioorganic & Medicinal Chemistry Letters, 2012, Pathak, Ravindra B.; Chovatia, P.T.; Parekh, H.H.
Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives
score: 1.5465102, Bioorganic & Medicinal Chemistry Letters, 2012, Pathak, Ravindra B.; Chovatia, P.T.; Parekh, H.H.
Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter
score: 1.5465079, Bioorganic & Medicinal Chemistry Letters, 2012, Qiao, Hongwen et. al.
Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter
score: 1.5465079, Bioorganic & Medicinal Chemistry Letters, 2012, Qiao, Hongwen et. al.
Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter
score: 1.5465079, Bioorganic & Medicinal Chemistry Letters, 2012, Qiao, Hongwen et. al.
Some aspects of NaBH 4 reduction in NMP
score: 1.5464935, Bioorganic & Medicinal Chemistry, 2002, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Structure–activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A 3 receptor antagonists
score: 1.5462797, Bioorganic & Medicinal Chemistry, 2004, Jung, Kwan-Young et. al.
A QSAR review on melanoma toxicity
score: 1.5462782, Bioorganic & Medicinal Chemistry, 2005, Verma, Rajeshwar P. et. al.
Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors
score: 1.5462493, European Journal of Medicinal Chemistry, 2012, Wani, Mohmmad Younus et. al.
Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides
score: 1.5461861, Bioorganic & Medicinal Chemistry Letters, 2001, Fujiwara, Tsuyoshi et. al.
Synthesis and antiproliferative evaluation of certain pyrido[3,2- g]quinoline derivatives
score: 1.5461603, Bioorganic & Medicinal Chemistry, 2006, Li, Shu-Yu et. al.
Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity
score: 1.5461201, Bioorganic & Medicinal Chemistry, 2003, Martinez, Ana et. al.
Design of novel synthetic MTS conjugates of bile acids for site-directed sulfhydryl labeling of cysteine residues in bile acid binding and transporting proteins
score: 1.5460564, Bioorganic & Medicinal Chemistry Letters, 2006, Ray, Abhijit et. al.
Cardioselective anti-ischemic ATP-sensitive potassium channel (K ATP) openers: benzopyranyl indoline and indole analogues
score: 1.5460184, European Journal of Medicinal Chemistry, 2003, Lee, Sunkyung et. al.
Conformationally restrained carbazolone-containing α,γ-diketo acids as inhibitors of HIV integrase
score: 1.5460047, Bioorganic & Medicinal Chemistry, 2006, Li, Xingnan; Vince, Robert
Evaluation of short-tether Bis-THA AChE inhibitors. A further test of the dual binding site hypothesis
score: 1.545726, Bioorganic & Medicinal Chemistry, 1999, Carlier, Paul R. et. al.
1,2,4-Triazino-[5,6 b]indole derivatives: effects of the trifluoromethyl group on in vitro antimalarial activity
score: 1.5456722, Bioorganic & Medicinal Chemistry, 2005, Kgokong, Joseph L.; Smith, Peter P.; Matsabisa, Gilbert M.
A new 9,11-Secosterol from the Soft Corals Sinularia granosa
score: 1.5456591, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Chiung-Yao et. al.
Synthesis, radiolabeling and initial in vivo evaluation of [11C]KSM-01 for imaging PPAR-α receptors
score: 1.5455191, Bioorganic & Medicinal Chemistry Letters, 2012, Solingapuram Sai, Kiran Kumar et. al.
Molecular iodine catalyzed synthesis of aryl-14 H-dibenzo[ a, j]xanthenes under solvent-free condition
score: 1.5455174, Bioorganic & Medicinal Chemistry Letters, 2007, Pasha, Mohamed A.; Jayashankara, Vaderapura P.
In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4
score: 1.5454305, European Journal of Medicinal Chemistry, 2012, Mur Blanch, Núria et. al.
In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4
score: 1.5454305, European Journal of Medicinal Chemistry, 2012, Mur Blanch, Núria et. al.
Synthesis of novel 4′-substituted 16-membered ring macrolide antibiotics derived from leucomycins
score: 1.5450901, Bioorganic & Medicinal Chemistry Letters, 2004, Wang, Zhaolin; Jian, Tianying; Phan, Ly T.; Or, Yat Sun
Synthesis of some newer derivatives of substituted quinazolinonyl-2-oxo/thiobarbituric acid as potent anticonvulsant agents
score: 1.5450282, Bioorganic & Medicinal Chemistry, 2004, Archana, ; Srivastava, V.K; Kumar, Ashok
Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease
score: 1.5447543, Bioorganic & Medicinal Chemistry Letters, 2012, Chao, Xiaojuan et. al.
Genetic localization and molecular characterization of the nonS gene required for macrotetrolide biosynthesis in Streptomyces griseus DSM40695.
score: 1.544746, Antimicrobial agents and chemotherapy, 2000, Smith, W C; Xiang, L; Shen, B
Synthesis and in vivo biodistribution of BPA–Gd–DTPA complex as a potential MRI contrast carrier for neutron capture therapy
score: 1.5445928, Bioorganic & Medicinal Chemistry, 2005, Takahashi, Kazunori et. al.
Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling
score: 1.5445417, Bioorganic & Medicinal Chemistry, 2013, Green, Brad R. et. al.
Protein linear indices of the ‘macromolecular pseudograph α-carbon atom adjacency matrix’ in bioinformatics. Part 1: Prediction of protein stability effects of a complete set of alanine substitutions in Arc repressor
score: 1.5443522, Bioorganic & Medicinal Chemistry, 2005, Marrero-Ponce, Yovani et. al.
Synthesis of Novel Schiff Base Analogues of 4-Amino-1,5-dimethyl-2-phenylpyrazol-3-one and their Evaluation for Antioxidant and Anti-inflammatory Activity
score: 1.544035, Bioorganic & Medicinal Chemistry, 2012, Alam, Mohammad Sayed; Choi, Jung-Hyun; Lee, Dong-Ung
Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis
score: 1.5439453, Bioorganic & Medicinal Chemistry, 2005, Wels, Bas et. al.
Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: Synthesis and preliminary evaluation as antimicrobial agents
score: 1.5439436, Bioorganic & Medicinal Chemistry, 2006, Metwally, Kamel A. et. al.
Exploring predictive QSAR models for hepatocyte toxicity of phenols using QTMS descriptors
score: 1.5439144, Bioorganic & Medicinal Chemistry Letters, 2008, Roy, Kunal; Popelier, Paul L.A.
Synthesis of benzenepropanamine analogues as non-detergent spermicides with antitrichomonas and anticandida activities
score: 1.5437805, Bioorganic & Medicinal Chemistry, 2006, Kiran Kumar, S.T.V.S. et. al.
Synthetic menthyl α/β-(1→6)-diglucopyranosides–induced cell death in human leukemia cells is dependent on caspases
score: 1.543671, Bioorganic & Medicinal Chemistry Letters, 2012, Marrero, María Teresa et. al.
Identification and evaluation of apoptotic compounds from Garcinia oligantha
score: 1.5436656, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Xue-Mei et. al.
1-Phenylpyrazolo[3,4- d]pyrimidines as adenosine antagonists: the effects of substituents at C4 and C6
score: 1.5436132, Bioorganic & Medicinal Chemistry, 1997, Chebib, Mary; Quinn, Ronald J.
Extending p K a prediction accuracy: High-throughput p K a measurements to understand p K a modulation of new chemical series
score: 1.5435896, European Journal of Medicinal Chemistry, 2010, Milletti, Francesca et. al.
Annonaceous acetogenins from the Leaves of Annona montana
score: 1.5435623, Bioorganic & Medicinal Chemistry, 2002, Wang, Li-Quan et. al.
Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices
score: 1.5435125, Bioorganic & Medicinal Chemistry Letters, 2004, Suzuki, Ichiro et. al.
2-Aminotetralin-derived substituted benzamides with mixed dopamine D 2, D 3, and serotonin 5-HT 1A receptor binding properties: A novel class of potential atypical antipsychotic agents
score: 1.5434353, Bioorganic & Medicinal Chemistry, 1998, Homan, Evert J. et. al.
Synthesis and antiamoebic activity of new oxime ether derivatives containing 2-acetylpyridine/2-acetylfuran
score: 1.5432306, Bioorganic & Medicinal Chemistry Letters, 2005, Abid, Mohammad; Husain, Kakul; Azam, Amir
Markov entropy backbone electrostatic descriptors for predicting proteins biological activity
score: 1.5431572, Bioorganic & Medicinal Chemistry Letters, 2004, González-Dı́az, Humberto; Molina, Reinaldo; Uriarte, Eugenio
Synthesis of novel thiazolothiazepine based HIV-1 integrase inhibitors
score: 1.5431434, Bioorganic & Medicinal Chemistry, 2004, Aiello, Francesca et. al.
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives
score: 1.5431374, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Yingqian et. al.
Hologram quantitative structure activity relationship studies on 5-HT 6 antagonists
score: 1.5428815, Bioorganic & Medicinal Chemistry, 2004, Doddareddy, Munikumar Reddy et. al.
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents
score: 1.5428415, European Journal of Medicinal Chemistry, 2012, Marhadour, Sophie et. al.
Synthesis and hybridization properties of the conjugates of oligonucleotides and stabilization agents. Part 3
score: 1.5427945, Bioorganic & Medicinal Chemistry, 2005, Sottofattori, Enzo et. al.
Design, Synthesis, and Pharmacological Evaluation of Novel Tetrahydroprotoberberine Derivatives: Selective Inhibitors of Dopamine D1 Receptor
score: 1.542765, Bioorganic & Medicinal Chemistry, 2012, Qian, Wangke et. al.
Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues
score: 1.5425798, European Journal of Medicinal Chemistry, 2012, Jubie, Selvaraj et. al.
Pharmacophore identification and 3D-QSAR studies in N-(2-benzoyl phenyl)- l-tyrosines as PPARγ agonists
score: 1.5424356, Bioorganic & Medicinal Chemistry, 2004, Rathi, Lalit et. al.
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones
score: 1.5424045, European Journal of Medicinal Chemistry, 2012, Point, Vanessa et. al.
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones
score: 1.5424045, European Journal of Medicinal Chemistry, 2012, Point, Vanessa et. al.
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: Synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities
score: 1.5423509, European Journal of Medicinal Chemistry, 2012, Kaur, Kirandeep et. al.
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress
score: 1.5422445, European Journal of Medicinal Chemistry, 2012, Chavarría, Cecilia et. al.
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress
score: 1.5422445, European Journal of Medicinal Chemistry, 2012, Chavarría, Cecilia et. al.
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress
score: 1.5422445, European Journal of Medicinal Chemistry, 2012, Chavarría, Cecilia et. al.
Synthesis and In vitro platelet aggregation and TP receptor binding studies on bicyclic 5,8-Ethanooctahydroisoquinolines and 5,8-Ethanotetrahydroisoquinolines
score: 1.5421775, Bioorganic & Medicinal Chemistry, 2002, Saha, Shankar L et. al.
Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide
score: 1.542123, European Journal of Medicinal Chemistry, 2006, Küçükgüzel, Güniz et. al.
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
score: 1.5420652, Bioorganic & Medicinal Chemistry, 2012, Chen, Di et. al.
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
score: 1.5420652, Bioorganic & Medicinal Chemistry, 2012, Chen, Di et. al.
A study on the conversion of indanones into carbostyrils
score: 1.5419148, Bioorganic & Medicinal Chemistry, 2003, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool
score: 1.5418607, Bioorganic & Medicinal Chemistry, 2008, Takakusagi, Yoichi et. al.
C3′- cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: Synthesis and SAR studies
score: 1.5418211, Bioorganic & Medicinal Chemistry, 2005, González, Rosario et. al.
Synthesis of pathogen inactivating nucleic acid intercalators
score: 1.5418206, European Journal of Medicinal Chemistry, 2004, Csuk, René et. al.
Inhibitors of glycogen phosphorylase b: synthesis, biochemical screening, and molecular modeling studies of novel analogues of hydantocidin
score: 1.5418053, Bioorganic & Medicinal Chemistry, 1998, Agasimundin, Yankanagouda S. et. al.
Novel tacrine derivatives that block neuronal calcium channels
score: 1.5417267, Bioorganic & Medicinal Chemistry, 2002, de los Rı́os, Cristóbal et. al.
Design, synthesis, and structure–activity relationship studies of novel millepachine derivatives as potent antiproliferative agents
score: 1.5416721, European Journal of Medicinal Chemistry, 2012, Wang, Guangcheng et. al.
A Specific Molecular Beacon Probe for the Detection of Human Prostate Cancer Cells
score: 1.541459, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Yu Lin et. al.
Discovery of small molecule HIV-1 Integrase Dimerization inhibitors
score: 1.5411964, Bioorganic & Medicinal Chemistry Letters, 2012, Tintori, Cristina et. al.
Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones
score: 1.5410251, European Journal of Medicinal Chemistry, 2013, Konduru, Naveen Kumar et. al.
Identification of the actinorhodin monomer and its related compound from a deletion mutant of the actVA-ORF4 gene of Streptomyces coelicolor A3(2)
score: 1.5410129, Bioorganic & Medicinal Chemistry Letters, 2012, Taguchi, Takaaki et. al.
Comparative QSAR modelling of 2-phenylindole-3-carbaldehyde derivatives as potential antimitotic agents
score: 1.5409431, Bioorganic & Medicinal Chemistry Letters, 2009, Halder, Amit Kumar; Adhikari, Nilanjan; Jha, Tarun
Thioredoxin reductase and cancer cell growth inhibition by organotellurium compounds that could be selectively incorporated into tumor cells
score: 1.5408331, Bioorganic & Medicinal Chemistry, 2003, Engman, Lars et. al.
Studies on the interaction of the antibiotic moenomycin A with the enzyme penicillin-binding protein 1b
score: 1.5407218, Bioorganic & Medicinal Chemistry, 2003, Rühl, Thomas et. al.
Design, synthesis and structure–activity relationships of a series of 9-substituted adenine derivatives as selective phosphodiesterase type-4 inhibitors
score: 1.5406003, European Journal of Medicinal Chemistry, 2003, Raboisson, Pierre et. al.
Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid
score: 1.5405123, Bioorganic & Medicinal Chemistry Letters, 2010, Vlahov, Iontcho R. et. al.
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit
score: 1.5402172, Bioorganic & Medicinal Chemistry, 2003, Gazit, Aviv et. al.
Molecular basis for fungal selectivity of novel antimitotic compounds.
score: 1.5399305, Antimicrobial agents and chemotherapy, 2003, Lila, Thomas et. al.
Synthesis and biological evaluation ofN-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and theirN-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases
score: 1.5399156, European Journal of Medicinal Chemistry, 2013, Loidreau, Yvonnick et. al.
Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases
score: 1.5399156, European Journal of Medicinal Chemistry, 2013, Loidreau, Yvonnick et. al.
Synthesis and biological evaluation of new mannose 6-phosphate analogues
score: 1.5397416, Bioorganic & Medicinal Chemistry, 2002, Vidal, Sébastien et. al.
Discovery of nor-seco himbacine analogs as thrombin receptor antagonists
score: 1.5396074, Bioorganic & Medicinal Chemistry Letters, 2012, Chelliah, Mariappan V. et. al.
Predicting multiple drugs side effects with a general drug-target interaction thermodynamic Markov model
score: 1.5395812, Bioorganic & Medicinal Chemistry, 2005, González-Dı́az, Humberto et. al.
Brønsted acid-catalyzed Nazarov cyclization of pyrrole derivatives accelerated by microwave irradiation
score: 1.5393936, Bioorganic & Medicinal Chemistry Letters, 2009, Bachu, Prabhakar; Akiyama, Takahiko
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents
score: 1.5393923, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ting et. al.
Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors
score: 1.5391622, Bioorganic & Medicinal Chemistry, 2006, Salameh, B.A.; Sundin, A.; Leffler, H.; Nilsson, U.J.
Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7 H-benz[ de]anthracene, 7-oxo-7 H-naphtho[1,2,3- de]quinoline, and 7-oxo-7 H-benzo[ e]perimidine
score: 1.5391233, Bioorganic & Medicinal Chemistry, 2005, Bu, Xianyong et. al.
Design, synthesis and antiviral activity of novel pyridazines
score: 1.5390453, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
Design, synthesis and antiviral activity of novel pyridazines
score: 1.5390453, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
Design, synthesis and antiviral activity of novel pyridazines
score: 1.5390453, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides
score: 1.539022, Bioorganic & Medicinal Chemistry, 2004, Sun, Hongmao et. al.
Nonsteroidal progesterone receptor ligands (I): Synthesis and SAR of new tetrahydronaphthofuranone derivatives
score: 1.5388225, Bioorganic & Medicinal Chemistry, 2006, Shinei, Rie et. al.
Chemical reactivity and microbicidal action of bethoxazin
score: 1.5383712, Bioorganic & Medicinal Chemistry, 2012, Chee, Gaik-Lean et. al.
Activity Landscape Modeling of PPAR ligands with Dual-Activity Difference Maps
score: 1.5381985, Bioorganic & Medicinal Chemistry, 2012, Méndez-Lucio, Oscar et. al.
Juglone derivatives as antitubercular agents: A rationale for the activity profile
score: 1.5380845, European Journal of Medicinal Chemistry, 2009, Sharma, Smriti; Sharma, Brij K.; Prabhakar, Yenamandra S.
Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
score: 1.5378824, European Journal of Medicinal Chemistry, 2012, Mourad, Mai A.E. et. al.
A synthetic entry to pladienolide B and FD-895
score: 1.5378702, Bioorganic & Medicinal Chemistry Letters, 2007, Mandel, Alexander L. et. al.
Discovery and Evolution of Phenoxypiperidine Hydroxyamide Dual CCR3/H1 Antagonists. Part II: Optimising in vivo Clearance
score: 1.5378064, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
Novel 3-hydroxy vinylboronates influence sphingolipid metabolism, cause apoptosis in Jurkat cells and prevent tumor development in nude mice
score: 1.5377857, Bioorganic & Medicinal Chemistry Letters, 2013, Botvinik Livshits, Alina et. al.
Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles
score: 1.5376443, Bioorganic & Medicinal Chemistry Letters, 1998, Xu, Wei; Mohan, Raju; Morrissey, Michael M.
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2
score: 1.5375882, Bioorganic & Medicinal Chemistry Letters, 2012, Bakmiwewa, Supun M. et. al.
Design, synthesis and QSAR studies on N-aryl heteroarylisopropanolamines, a new class of non-peptidic HIV-1 protease inhibitors
score: 1.5374239, Bioorganic & Medicinal Chemistry, 2002, Di Santo, Roberto et. al.
Synthesis and anti-inflammatory evaluation of 4-anilinofuro[2,3- b]quinoline and 4-phenoxyfuro[2,3- b]quinoline derivatives. Part 3
score: 1.5372582, Bioorganic & Medicinal Chemistry, 2004, Chen, Yeh-Long et. al.
Non-peptidic, non-prenylic bisubstrate farnesyltransferase inhibitors. Part 3: structural requirements of the central moiety for farnesyltransferase inhibitory activity
score: 1.537243, Bioorganic & Medicinal Chemistry, 2000, Schlitzer, Martin; Böhm, Markus; Sattler, Isabel
Biaryl modification of the 5′-terminus of one strand of a microRNA duplex induces strand specificity
score: 1.537207, Bioorganic & Medicinal Chemistry Letters, 2010, Ogata, Aya et. al.
Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives
score: 1.5371284, European Journal of Medicinal Chemistry, 2012, Liu, Jingbao et. al.
Identification of a methotrexate-binding peptide from a T7 phage display screen using a QCM device
score: 1.5369849, Bioorganic & Medicinal Chemistry, 2008, Takakusagi, Yoichi et. al.
Synthesis of a ratiometric fluorescent peptide sensor for the highly selective detection of Cd2+
score: 1.5369506, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Yan et. al.
Chemical and enzymatic synthesis of fructose analogues as probes for import studies by the hexose transporter in parasites
score: 1.5368373, Bioorganic & Medicinal Chemistry, 2000, Azéma, Laurent et. al.
Elucidating inhibitory models of the inhibitors of epidermal growth factor receptor by docking and 3D-QSAR
score: 1.5367988, Bioorganic & Medicinal Chemistry, 2004, Chen, Gang et. al.
Synthesis and immobilization of ceramide analogs on silica particles
score: 1.5367965, Bioorganic & Medicinal Chemistry Letters, 1998, Yin, Jianming; Liu, Hanlan; Pidgeon, Charles
Synthesis and analysis of urea and carbamate prodrugs as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT)
score: 1.5365559, Bioorganic & Medicinal Chemistry, 2002, Jordan, Allan M. et. al.
Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta
score: 1.5364333, Bioorganic & Medicinal Chemistry Letters, 2008, Liu, Yongsheng et. al.
Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents
score: 1.5362933, European Journal of Medicinal Chemistry, 2012, Ponaire, Sarah et. al.
Synthesis and Antimycobacterial Activity of Some Phthalimid Derivatives
score: 1.536179, Bioorganic & Medicinal Chemistry, 2012, Akgün, Hülya et. al.
Prediction of hERG potassium channel affinity by the CODESSA approach
score: 1.5360022, Bioorganic & Medicinal Chemistry, 2006, Coi, Alessio et. al.
New fluorinated derivatives as esterase inhibitors. Synthesis, hydration and crossed specificity studies
score: 1.5358999, Bioorganic & Medicinal Chemistry, 2003, Quero, Carmen et. al.
A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid
score: 1.5358582, Bioorganic & Medicinal Chemistry, 2013, Setoguchi, Masaki et. al.
Xanthone derivatives as potential inhibitors of miRNA processing by human Dicer: Targeting secondary structures of pre-miRNA by small molecules
score: 1.5357842, Bioorganic & Medicinal Chemistry Letters, 2013, Murata, Asako et. al.
Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues
score: 1.5357646, European Journal of Medicinal Chemistry, 2012, Kozic, Ján et. al.
Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues
score: 1.5357646, European Journal of Medicinal Chemistry, 2012, Kozic, Ján et. al.
Synthesis and biological evaluations of pyrazolo[3,4- d]pyrimidines as cyclin-dependent kinase 2 inhibitors
score: 1.5356936, European Journal of Medicinal Chemistry, 2003, Kim, Dong Chan et. al.
Comparative molecular similarity indices analysis (CoMSIA) studies of 1,2-naphthoquinone derivatives as PTP1B inhibitors
score: 1.5353901, Bioorganic & Medicinal Chemistry, 2005, Sobhia, M. Elizabeth; Bharatam, Prasad V.
Syntheses of phosphatidyl-β- d-glucoside analogues to probe antigen selectivity of monoclonal antibody ‘DIM21’
score: 1.5353796, Bioorganic & Medicinal Chemistry, 2008, Greimel, Peter et. al.
Synthesis of dihydronaphthofurandiones and dihydrofuroquinolinediones with trypanocidal activity and analysis of their stereoelectronic properties
score: 1.5353524, Bioorganic & Medicinal Chemistry, 2004, Tapia, Ricardo A. et. al.
Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists
score: 1.5353086, Bioorganic & Medicinal Chemistry, 2006, Gillman, Kevin W. et. al.
Stereoselective synthesis of Alpinoid-C and its analogues and study of their cytotoxic activity against cancer cell lines
score: 1.5349979, Bioorganic & Medicinal Chemistry Letters, 2012, Purushotham Reddy, S. et. al.
Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists
score: 1.5349841, Bioorganic & Medicinal Chemistry Letters, 2012, Cherney, Robert J. et. al.
Synthesis and evaluation of fructose analogues as inhibitors of the d-fructose transporter GLUT5
score: 1.534846, Bioorganic & Medicinal Chemistry, 2000, Tatibouët, Arnaud et. al.
Synthesis of 2,4-Diamino-6-(thioarylmethyl)pyrido[2,3- d]pyrimidines as dihydrofolate reductase inhibitors
score: 1.5348337, Bioorganic & Medicinal Chemistry, 2001, Gangjee, Aleem; Adair, Ona; Queener, Sherry F.
Volsurf analysis of carbapenem antibiotics
score: 1.5348202, Bioorganic & Medicinal Chemistry, 2005, Doddareddy, Munikumar Reddy et. al.
Novel SHV-derived extended-spectrum beta-lactamase, SHV-57, that confers resistance to ceftazidime but not cefazolin.
score: 1.5347727, Antimicrobial agents and chemotherapy, 2005, Ma, Ling et. al.
Leishmanicidal activities and cytotoxicities of bisnaphthoquinone analogues and naphthol derivatives from Burman Diospyros burmanica
score: 1.5345074, Bioorganic & Medicinal Chemistry, 2012, Mori-Yasumoto, Kanami et. al.
Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents
score: 1.5344536, European Journal of Medicinal Chemistry, 2012, Jiang, Nan et. al.
Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents
score: 1.5344536, European Journal of Medicinal Chemistry, 2012, Jiang, Nan et. al.
Synthesis of a small library of phenylalkylamide derivatives as melatoninergic ligands for human mt 1 and MT 2 receptors
score: 1.534345, Bioorganic & Medicinal Chemistry, 2000, Pégurier, Cécile et. al.
New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides
score: 1.5342635, Bioorganic & Medicinal Chemistry Letters, 2012, Jervis, Peter J. et. al.
New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides
score: 1.5342635, Bioorganic & Medicinal Chemistry Letters, 2012, Jervis, Peter J. et. al.
Discovery of novel sulfonated small molecules that inhibit vascular tube formation
score: 1.5342532, Bioorganic & Medicinal Chemistry Letters, 2012, Raman, Karthik et. al.
Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units
score: 1.5338959, Bioorganic & Medicinal Chemistry, 1998, Angiolini, Mauro et. al.
Synthesis and characterisation of a new pH-sensitive amphotericin B—poly(ethylene glycol)- b-poly( l-lysine) conjugate
score: 1.5338194, Bioorganic & Medicinal Chemistry Letters, 2007, Sedlák, Miloš et. al.
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors
score: 1.5338068, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Xue Zhi et. al.
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors
score: 1.5338068, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Xue Zhi et. al.
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors
score: 1.5338068, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Xue Zhi et. al.
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
score: 1.5335169, Antimicrobial agents and chemotherapy, 2012, Lu, Meiqing et. al.
Disubstituted thiourea derivatives and their activity on CNS: Synthesis and biological evaluation
score: 1.5334486, European Journal of Medicinal Chemistry, 2012, Stefanska, Joanna et. al.
Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.
score: 1.5334245, Antimicrobial agents and chemotherapy, 2011, Shih, I-Hung et. al.
A convenient method for the computer-Aided molecular design of carborane containing compounds
score: 1.5333743, Bioorganic & Medicinal Chemistry Letters, 2003, Johnsamuel, Jayaseharan et. al.
Synthesis and immunomodulatory properties of selected oxazolone derivatives
score: 1.533079, Bioorganic & Medicinal Chemistry, 2004, Mesaik, Muhammad A et. al.
Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria
score: 1.533078, Bioorganic & Medicinal Chemistry, 2003, Radin, Norman S.
QSAR study on competition binding of rodenticides (PATs) to H 1 receptor in rat and guinea pig brain
score: 1.5330671, Bioorganic & Medicinal Chemistry, 2002, Agrawal, Vijay K.; Karmarkar, Sanjay; Khadikar, Padmakar V.
Facile and improved synthesis of 4β-aminopodophyllotoxin congeners
score: 1.5330557, Bioorganic & Medicinal Chemistry Letters, 1998, Kamal, Ahmed; Lakshmi Gayatri, N.; Venugopal Rao, N.
Wake Promoting Agents: Search for Next Generation Modafinil, Lessons Learned: Part III
score: 1.533019, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Parallel solid-phase synthesis and characterization of new sulfonamide and carboxamide proline derivatives as potential CNS agents
score: 1.5329593, Bioorganic & Medicinal Chemistry, 2005, Zajdel, Paweł et. al.
η 4-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)
score: 1.532786, Bioorganic & Medicinal Chemistry Letters, 2006, Fairlamb, Ian J.S. et. al.
Antiproliferative activity of salinomycin and its derivatives
score: 1.5327824, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam et. al.
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents
score: 1.532733, Bioorganic & Medicinal Chemistry, 2012, Gangjee, Aleem et. al.
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents
score: 1.532733, Bioorganic & Medicinal Chemistry, 2012, Gangjee, Aleem et. al.
QSAR study for mycobacterial promoters with low sequence homology
score: 1.5325698, Bioorganic & Medicinal Chemistry Letters, 2006, González-Díaz, Humberto et. al.
Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives
score: 1.5324325, European Journal of Medicinal Chemistry, 2012, Shulaeva, M.M. et. al.
Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives
score: 1.5324325, European Journal of Medicinal Chemistry, 2012, Shulaeva, M.M. et. al.
Unique anti-human immunodeficiency virus activities of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide, and dihydrocostatolide.
score: 1.5324261, Antimicrobial agents and chemotherapy, 1999, Buckheit, R W et. al.
Synthesis and BZR affinity of pyrazolo[1,5- a]pyrimidine derivatives. part 1: study of the structural features for BZR recognition
score: 1.5319842, Bioorganic & Medicinal Chemistry, 1999, Selleri, Silvia et. al.
Alstiphyllanines I – O, Ajmaline Type Alkaloids from Alstonia macrophylla showing Vasorelaxant Activity
score: 1.5319601, Bioorganic & Medicinal Chemistry, 2012, Arai, Hiroko et. al.
Discovery of a new antileishmanial hit in 8-nitroquinoline series
score: 1.5319474, European Journal of Medicinal Chemistry, 2012, Paloque, Lucie et. al.
Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir.
score: 1.5316039, Antimicrobial agents and chemotherapy, 2001, Bantia, S et. al.
Lead optimization through VLAK protocol: New annelated pyrrolo-pyrimidine derivatives as antitumor agents
score: 1.5315361, European Journal of Medicinal Chemistry, 2012, Lauria, Antonino et. al.
1,8-Naphthyridines V. Novel N-substituted 5-amino- N, N-diethyl-9-isopropyl [1,2,4]triazolo[4,3- a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity
score: 1.5315073, European Journal of Medicinal Chemistry, 2005, Grossi, Giancarlo et. al.
Site-specific incorporation of PEGylated amino acids into proteins using nonnatural amino acid mutagenesis
score: 1.531277, Bioorganic & Medicinal Chemistry Letters, 2009, Shozen, Naoki; Iijima, Issei; Hohsaka, Takahiro
Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids
score: 1.5311728, European Journal of Medicinal Chemistry, 2012, Bortolini, Olga et. al.
Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids
score: 1.5311728, European Journal of Medicinal Chemistry, 2012, Bortolini, Olga et. al.
How cyclodextrins can mask their toxic effect on the blood–brain barrier
score: 1.5311312, Bioorganic & Medicinal Chemistry Letters, 2006, Binkowski-Machut, Cécile et. al.
Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity
score: 1.5310024, European Journal of Medicinal Chemistry, 2012, Yang, Xiao-Zhi et. al.
Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity
score: 1.5310024, European Journal of Medicinal Chemistry, 2012, Yang, Xiao-Zhi et. al.
Discovery of a new antileishmanial hit in 8-nitroquinoline series
score: 1.5307548, European Journal of Medicinal Chemistry, 2012, Paloque, Lucie et. al.
Discovery of a new antileishmanial hit in 8-nitroquinoline series
score: 1.5307548, European Journal of Medicinal Chemistry, 2012, Paloque, Lucie et. al.
Discovery of a new antileishmanial hit in 8-nitroquinoline series
score: 1.5307548, European Journal of Medicinal Chemistry, 2012, Paloque, Lucie et. al.
Antitumor agents—CLXVII. Synthesis and structure-activity correlations of the cytotoxic anthraquinone 1,4-bis-(2,3-epoxypropylamino)-9,10-anthracenedione, and of related compounds
score: 1.5307268, Bioorganic & Medicinal Chemistry, 1997, Johnson, Mary G. et. al.
Antitumor agents—CLXVII. Synthesis and structure-activity correlations of the cytotoxic anthraquinone 1,4-bis-(2,3-epoxypropylamino)-9,10-anthracenedione, and of related compounds
score: 1.5307268, Bioorganic & Medicinal Chemistry, 1997, Johnson, Mary G. et. al.
Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.
score: 1.5306709, Antimicrobial agents and chemotherapy, 2012, Lorenzón, E N et. al.
Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARα
score: 1.5305716, European Journal of Medicinal Chemistry, 2012, Ammazzalorso, Alessandra et. al.
Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARα
score: 1.5305716, European Journal of Medicinal Chemistry, 2012, Ammazzalorso, Alessandra et. al.
Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARα
score: 1.5305716, European Journal of Medicinal Chemistry, 2012, Ammazzalorso, Alessandra et. al.
QSAR study on some pyridoacridine ascididemin analogues as anti-tumor agents
score: 1.5302877, Bioorganic & Medicinal Chemistry, 2003, Debnath, Bikash et. al.
Proteins QSAR with Markov average electrostatic potentials
score: 1.5301451, Bioorganic & Medicinal Chemistry Letters, 2005, González-Díaz, Humberto; Uriarte, Eugenio
4-Substituted-2-phenylquinazolines as inhibitors of BCRP
score: 1.5298694, Bioorganic & Medicinal Chemistry Letters, 2012, Juvale, Kapil; Wiese, Michael
4-Substituted-2-phenylquinazolines as inhibitors of BCRP
score: 1.5298694, Bioorganic & Medicinal Chemistry Letters, 2012, Juvale, Kapil; Wiese, Michael
Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors
score: 1.5298353, Bioorganic & Medicinal Chemistry, 2006, Xiao, Kun et. al.
Synthesis and characterization of some new quinoline based derivatives endowed with broad spectrum antimicrobial potency
score: 1.5294972, Bioorganic & Medicinal Chemistry Letters, 2012, Desai, Nisheeth C.; Rajpara, Kiran M.; Joshi, Vivek V.
Synthesis and characterization of some new quinoline based derivatives endowed with broad spectrum antimicrobial potency
score: 1.5294972, Bioorganic & Medicinal Chemistry Letters, 2012, Desai, Nisheeth C.; Rajpara, Kiran M.; Joshi, Vivek V.
Synthesis and characterization of some new quinoline based derivatives endowed with broad spectrum antimicrobial potency
score: 1.5294972, Bioorganic & Medicinal Chemistry Letters, 2012, Desai, Nisheeth C.; Rajpara, Kiran M.; Joshi, Vivek V.
Orally active cephalosporins. Part 3: synthesis, structure–activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins
score: 1.5294805, Bioorganic & Medicinal Chemistry, 2001, Yamamoto, Hirofumi et. al.
Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
score: 1.5293761, Bioorganic & Medicinal Chemistry Letters, 2007, Matsuoka, Koji et. al.
N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration
score: 1.5290701, Bioorganic & Medicinal Chemistry Letters, 2012, Wei, Zhongyong et. al.
N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration
score: 1.5290701, Bioorganic & Medicinal Chemistry Letters, 2012, Wei, Zhongyong et. al.
N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration
score: 1.5290701, Bioorganic & Medicinal Chemistry Letters, 2012, Wei, Zhongyong et. al.
The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study
score: 1.5287735, European Journal of Medicinal Chemistry, 2012, Chapelat, Julien et. al.
The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study
score: 1.5287735, European Journal of Medicinal Chemistry, 2012, Chapelat, Julien et. al.
Stereoselective synthesis and antifungal activity of ( Z)- trans-3-azolyl-2-methylchromanone oxime ethers
score: 1.5286412, Bioorganic & Medicinal Chemistry, 2004, Emami, Saeed et. al.
Synthesis and in vitro muscarinic activities of a Series of 1,3-diazacycloalkyl carboxaldehyde oxime derivatives
score: 1.5284892, Bioorganic & Medicinal Chemistry, 2002, Plate, Ralf et. al.
Synthesis and nuclease stability of trilysyl dendrimer–oligodeoxyribonucleotide hybrids
score: 1.5283555, Bioorganic & Medicinal Chemistry Letters, 2001, Sarracino, David A; Richert, Clemens
Selective cytotoxicity of azatyrosinamides against ras-transformed NIH 3T3 cells
score: 1.5283089, Bioorganic & Medicinal Chemistry Letters, 2005, Wang, H.P. et. al.
Structure–activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription
score: 1.52806, Bioorganic & Medicinal Chemistry, 2012, Li, Bingbing X.; Yamanaka, Kinrin; Xiao, Xiangshu
Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action
score: 1.527958, Bioorganic & Medicinal Chemistry Letters, 2012, Thur, Yithachu et. al.
Synthesis, antitumor activity and SAR study of novel [1,2,4]Triazino[4,5-a]benzimidazole derivatives
score: 1.5279534, European Journal of Medicinal Chemistry, 2012, El-Nassan, Hala Bakr
Synthesis of a ratiometric fluorescent peptide sensor for the highly selective detection of Cd2+
score: 1.5279531, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Yan et. al.
Synthesis of a ratiometric fluorescent peptide sensor for the highly selective detection of Cd2+
score: 1.5279531, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Yan et. al.
First synthesis of optically active benzocyclobutene and biphenylene-based unusual α-amino acid derivatives
score: 1.5279527, Bioorganic & Medicinal Chemistry Letters, 1999, Kotha, Sambasivarao et. al.
First synthesis of optically active benzocyclobutene and biphenylene-based unusual α-amino acid derivatives
score: 1.5279527, Bioorganic & Medicinal Chemistry Letters, 1999, Kotha, Sambasivarao et. al.
Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones
score: 1.5279067, European Journal of Medicinal Chemistry, 2009, Pagano, Mariana et. al.
CoMFA and CoMSIA 3D QSAR analysis on N 1-arylsulfonylindole compounds as 5-HT 6 antagonists
score: 1.527849, Bioorganic & Medicinal Chemistry, 2004, Doddareddy, Munikumar Reddy et. al.
Preparation of dopaminergic N-alkyl-benzyltetrahydro-isoquinolines using a ‘one-pot’ procedure in acid medium
score: 1.5277752, Bioorganic & Medicinal Chemistry, 2000, Andreu, Inmaculada et. al.
Adenosine receptor modelling. A 1/A 2a selectivity
score: 1.527731, European Journal of Medicinal Chemistry, 2006, Tuccinardi, Tiziano et. al.
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors
score: 1.5277305, Bioorganic & Medicinal Chemistry, 2006, Loriga, Giovanni et. al.
Design, structural and spectroscopic elucidation, and the in vitro biological activities of new diorganotin dithiocarbamates
score: 1.5277108, European Journal of Medicinal Chemistry, 2012, Ferreira, Isabella P. et. al.
Design, structural and spectroscopic elucidation, and the in vitro biological activities of new diorganotin dithiocarbamates
score: 1.5277108, European Journal of Medicinal Chemistry, 2012, Ferreira, Isabella P. et. al.
Structure–activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase
score: 1.5276515, Bioorganic & Medicinal Chemistry, 2005, Ebdrup, Søren et. al.
Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells
score: 1.5273921, Bioorganic & Medicinal Chemistry Letters, 2012, Dandawate, Prasad et. al.
Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells
score: 1.5273921, Bioorganic & Medicinal Chemistry Letters, 2012, Dandawate, Prasad et. al.
Isolation and stomatal opening activity of two oxylipins from Ipomoea tricolor
score: 1.5272908, Bioorganic & Medicinal Chemistry Letters, 2005, Ohashi, Teruhisa et. al.
Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1 H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups
score: 1.5272168, Bioorganic & Medicinal Chemistry, 2005, Özden, Seçkin; Atabey, Dilek; Yıldız, Sulhiye; Göker, Hakan
Thieno[3,2-d]pyrimidin-4(3H)-one Derivatives as PDK1 Inhibitors Discovered by Fragment-based Screening
score: 1.5269586, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Angeline C.-H. et. al.
2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1
score: 1.5268847, Bioorganic & Medicinal Chemistry Letters, 2012, Blanchard, Stéphanie et. al.
Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A 1 and A 2A adenosine receptor antagonists
score: 1.5268614, Bioorganic & Medicinal Chemistry, 2006, Massip, Stéphane et. al.
Synthesis of oxysterols and nitrogenous sterols with antileishmanial and trypanocidal activities
score: 1.5267377, European Journal of Medicinal Chemistry, 2006, Bazin, Marc-Antoine et. al.
Zizimauritic acids A–C, three novel nortriterpenes from Ziziphus mauritiana
score: 1.5266765, Bioorganic & Medicinal Chemistry Letters, 2012, Ji, Chang-Jiu et. al.
Quantitative structure activity relationship studies of aryl heterocycle-based thrombin inhibitors
score: 1.5264683, European Journal of Medicinal Chemistry, 2006, Deswal, Sumit; Roy, Nilanjan
Synthesis and benzodiazepine receptor (ω receptor) affinities of 3-substituted derivatives of pyrrolo[2,3- c]pyridine-5-carboxylate, a novel class of ω 1 selective ligands 1 This article is dedicated to the memory of our friend and colleague, Sir Derek Barton. 1
score: 1.5262407, Bioorganic & Medicinal Chemistry, 1999, Doisy, Xavier et. al.
Design, Solvent free Synthesis, and antimicrobial evaluation of 1, 4 Dihydropyridines
score: 1.5257048, Bioorganic & Medicinal Chemistry Letters, 2012, Murthy, Y.L.N. et. al.
γ-Butyrobetaine Hydroxylase Catalyses a Stevens Type Rearrangement
score: 1.5256903, Bioorganic & Medicinal Chemistry Letters, 2012, Henry, Luc et. al.
Synthesis and biological evaluations of A-ring isomers of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D 3
score: 1.5256719, Bioorganic & Medicinal Chemistry, 2000, Ikeda, Masahiko et. al.
Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in vivo.
score: 1.5256691, Antimicrobial agents and chemotherapy, 2004, Alymova, Irina V et. al.
Synthesis of 13C-dehydrocoelenterazine and model studies on Symplectoteuthis squid bioluminescence
score: 1.5254701, Bioorganic & Medicinal Chemistry Letters, 1998, Isobe, Minoru et. al.
An improved synthesis of psammaplin A
score: 1.5254219, Bioorganic & Medicinal Chemistry Letters, 2006, Godert, Amy M. et. al.
Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents
score: 1.5253146, European Journal of Medicinal Chemistry, 2012, Shaaban, Saad et. al.
Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K
score: 1.5251218, Bioorganic & Medicinal Chemistry, 1999, Marquis, Robert W et. al.
The antibacterial activity of 4,4′-bipyridinium amphiphiles with conventional, bicephalic and gemini architectures
score: 1.5249631, Bioorganic & Medicinal Chemistry Letters, 2012, Grenier, Melissa C. et. al.
Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA 4 and enzymatic conversion to the LTC 4 analogue
score: 1.5248779, Bioorganic & Medicinal Chemistry Letters, 2000, Vidal, Agnès et. al.
Isoflavones inhibit the clonogenicity of human colon cancer cells
score: 1.5248547, Bioorganic & Medicinal Chemistry Letters, 2012, Hyun, Jiye et. al.
The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives
score: 1.52477, Bioorganic & Medicinal Chemistry Letters, 2013, Nemoto, Toru et. al.
Experimental and theoretical study on the structure and electronic spectra of imiquimod and its synthetic intermediates
score: 1.5247313, Bioorganic & Medicinal Chemistry Letters, 2007, Zhao, Bo; Rong, Yu-Zhi; Huang, Xiao-Hua; Shen, Jing-Shan
Theoretical structure-activity studies of adenosine A 1 ligands: requirements for receptor affinity
score: 1.5246763, Bioorganic & Medicinal Chemistry, 1996, Dooley, Michael J.; Kono, Motomichi; Suzuki, Fumio
First pharmacophoric hypothesis for T-type calcium channel blockers
score: 1.5246097, Bioorganic & Medicinal Chemistry, 2004, Doddareddy, Munikumar Reddy et. al.
Anti-AIDS agents—XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives
score: 1.5245994, Bioorganic & Medicinal Chemistry, 1997, Hashimoto, Fumio et. al.
Synthesis and inhibitory activity of dimethylamino-chalcone derivatives on the induction of nitric oxide synthase
score: 1.5245616, European Journal of Medicinal Chemistry, 2002, Rojas, Javier et. al.
2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine–entecavir resistant triple mutant and its mechanism of action
score: 1.5244913, Bioorganic & Medicinal Chemistry Letters, 2013, Rawal, Ravindra K. et. al.
Synthesis and antiproliferative activity of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles
score: 1.524252, Bioorganic & Medicinal Chemistry, 2006, Matysiak, Joanna; Opolski, Adam
Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives
score: 1.5242408, European Journal of Medicinal Chemistry, 2012, Raimondi, Maria Valeria et. al.
Depigmenting activity of new kojic acid derivative obtained as a side product in the synthesis of cinnamate of kojic acid
score: 1.5241208, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Jun-Cheol et. al.
New 3- and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents
score: 1.5239946, Bioorganic & Medicinal Chemistry, 2005, Weber, Valérie et. al.
A mechanistic study on the nuclease activities of some hydroxystilbenes
score: 1.5239576, Bioorganic & Medicinal Chemistry, 2004, Subramanian, Mahesh et. al.
Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers
score: 1.5238852, Bioorganic & Medicinal Chemistry, 2005, Sanmartín, Carmen et. al.
Computer-aided analysis of the interactions of glutamine synthetase with its inhibitors
score: 1.5238377, Bioorganic & Medicinal Chemistry, 2006, Berlicki, Łukasz; Kafarski, Paweł
Design and synthesis of low molecular weight compounds with complement inhibition activity
score: 1.5238044, Bioorganic & Medicinal Chemistry, 2005, Master, Hoshang E.; Khan, Shabana I.; Poojari, Krishna A.
Studies on the porcine liver esterase-catalyzed hydrolysis of pentaacetyl catechin and epicatechin: Application to the synthesis of novel dimers and trimers
score: 1.5236332, Bioorganic & Medicinal Chemistry Letters, 2008, Basak, Amit; Das, Sanket; Bisai, Shrabani
Discovery and Evolution of Phenoxypiperidine Hydroxyamide Dual CCR3/H1 Antagonists. Part I
score: 1.523535, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
Quantitative structure–activity relationship analysis of aryl alkanol piperazine derivatives with antidepressant activities
score: 1.5232497, European Journal of Medicinal Chemistry, 2009, Chen, Ke-Xian et. al.
2′- O,4′- C-methylene bridged nucleic acid (2′,4′-BNA)
score: 1.5232105, Bioorganic & Medicinal Chemistry, 2001, Obika, Satoshi et. al.
Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells
score: 1.523209, Bioorganic & Medicinal Chemistry Letters, 2013, Helal, Muath et. al.
A specific molecular beacon probe for the detection of human prostate cancer cells
score: 1.5231983, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Yu Lin et. al.
A specific molecular beacon probe for the detection of human prostate cancer cells
score: 1.5231983, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Yu Lin et. al.
A specific molecular beacon probe for the detection of human prostate cancer cells
score: 1.5231983, Bioorganic & Medicinal Chemistry Letters, 2012, Jiang, Yu Lin et. al.
Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator.
score: 1.5231855, Antimicrobial agents and chemotherapy, 2003, Cain, Cody C et. al.
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol
score: 1.5231343, Bioorganic & Medicinal Chemistry, 2012, Cho, Suengmok et. al.
Synthesis of novel substituted tetrazoles having antifungal activity
score: 1.5230874, European Journal of Medicinal Chemistry, 2004, Upadhayaya, Ram Shankar et. al.
Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol
score: 1.5230787, Bioorganic & Medicinal Chemistry Letters, 2012, Vijai Kumar Reddy, T. et. al.
One-Electron reduction characteristics of N(3)-Substituted 5-fluorodeoxyuridines synthesized as radiation-Activated prodrugs
score: 1.5230705, Bioorganic & Medicinal Chemistry, 2003, Tanabe, Kazuhito et. al.
Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2′-deoxyuridines
score: 1.5229459, Bioorganic & Medicinal Chemistry, 2010, Andersen, Nicolai Krog et. al.
Structural Modifications of a 3-Methoxy-2-Aminopyridine Compound to Reduce Potential for Mutagenicity and Time-Dependent Drug-Drug Interaction
score: 1.5228712, Bioorganic & Medicinal Chemistry Letters, 2012, Palmer, Cynthia et. al.
In vitro and in vivo antibacterial activities of OPC-20011, a novel parenteral broad-spectrum 2-oxaisocephem antibiotic.
score: 1.5228217, Antimicrobial agents and chemotherapy, 1998, Matsumoto, M; Tamaoka, H; Ishikawa, H; Kikuchi, M
Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta
score: 1.5226996, Bioorganic & Medicinal Chemistry Letters, 2004, Hangeland, Jon J. et. al.
Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors
score: 1.5226117, Bioorganic & Medicinal Chemistry, 2012, Mane, U.R. et. al.
Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors
score: 1.5226117, Bioorganic & Medicinal Chemistry, 2012, Mane, U.R. et. al.
Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors
score: 1.5226117, Bioorganic & Medicinal Chemistry, 2012, Mane, U.R. et. al.
The influence of molecular conformation upon the self-assembly of cyclohexane diamide diacids
score: 1.5225539, Bioorganic & Medicinal Chemistry, 1997, Bergeron, Raymond J. et. al.
Synthesis and biological evaluation of homoserine lactone derived ureas as antagonists of bacterial quorum sensing
score: 1.5225355, Bioorganic & Medicinal Chemistry, 2006, Frezza, Marine et. al.
Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya
score: 1.5224866, Bioorganic & Medicinal Chemistry, 2005, Dijoux, Marie-Geneviève et. al.
A versatile access to new macrocyclic oligoheterocycles (MOH)
score: 1.5224165, Bioorganic & Medicinal Chemistry Letters, 2006, Nefzi, Adel; Santos, Rodegar T.
Synthesis of Feruloyl- myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and esptein–barr virus activation
score: 1.5221779, Bioorganic & Medicinal Chemistry, 2002, Hosoda, Asao et. al.
Labdane-type Diterpenes with Inhibitory Effects on Increase in Vascular Permeability and Nitric Oxide Production from Hedychium coronarium
score: 1.5221043, Bioorganic & Medicinal Chemistry, 2002, Matsuda, Hisashi et. al.
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
score: 1.5220998, Bioorganic & Medicinal Chemistry, 2012, Chen, Di et. al.
Quantifying Biogenic Bias in Screening Libraries
score: 1.5218652, Nature chemical biology, 2009, Hert, Jérôme et. al.
Synthesis and antiangiogenic activity of thioacetal artemisinin derivatives
score: 1.5217735, Bioorganic & Medicinal Chemistry, 2004, Oh, Sangtae et. al.
Design, synthesis, and evaluation of a novel class of 2,3-disubstituted-tetrahydro-β-carboline derivatives
score: 1.5216694, Bioorganic & Medicinal Chemistry Letters, 2012, Zeng, Li; Zhang, Jianwei
Design, synthesis, and evaluation of a novel class of 2,3-disubstituted-tetrahydro-β-carboline derivatives
score: 1.5216694, Bioorganic & Medicinal Chemistry Letters, 2012, Zeng, Li; Zhang, Jianwei
Design, synthesis, and evaluation of a novel class of 2,3-disubstituted-tetrahydro-β-carboline derivatives
score: 1.5216694, Bioorganic & Medicinal Chemistry Letters, 2012, Zeng, Li; Zhang, Jianwei
Synthesis of novel chromene derivatives of expected antitumor activity
score: 1.5216565, European Journal of Medicinal Chemistry, 2013, Kandeel, Manal M. et. al.
Synthesis of novel chromene derivatives of expected antitumor activity
score: 1.5216565, European Journal of Medicinal Chemistry, 2013, Kandeel, Manal M. et. al.
Synthesis of thiophenyl substituted cyclohexa-2,4-dien-1-one and its photocleavage coupling reaction with amines
score: 1.5216539, Bioorganic & Medicinal Chemistry Letters, 2000, Kwon, Tae Woo et. al.
New quinazolinone-pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies
score: 1.521648, European Journal of Medicinal Chemistry, 2012, Abbas, Safinaz E. et. al.
UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety
score: 1.5216152, Bioorganic & Medicinal Chemistry, 2012, Ginsburg-Shmuel, Tamar et. al.
A two-step, one-pot synthesis of diverse N-pyruvoyl amino acid derivatives using the Ugi reaction
score: 1.521546, Bioorganic & Medicinal Chemistry Letters, 2000, Nakamura, Masayuki; Inoue, Jun; Yamada, Takashi
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata
score: 1.5215395, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Yunjiang; Bowden, Bruce F.; Kapoor, Vimal
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata
score: 1.5215395, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Yunjiang; Bowden, Bruce F.; Kapoor, Vimal
Quantitative Structure–Activity Analyses of Novel Hydroxyphenylurea Derivatives as Antioxidants
score: 1.5215152, Bioorganic & Medicinal Chemistry, 1998, Nakao, Kazuya et. al.
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance
score: 1.5214416, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
Fosfomycin Enhances the Active Transport of Tobramycin in Pseudomonas aeruginosa.
score: 1.5214416, Antimicrobial agents and chemotherapy, 2012, Macleod, David L et. al.
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance
score: 1.5214416, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
Synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the CB1 and CB2 receptors
score: 1.5213368, Bioorganic & Medicinal Chemistry, 2003, Nadipuram, Asha K et. al.
Peroxidase catalyzed formation of azine pigments—a convenient and sensitive method for the identification of human cells with positive myeloperoxidase reactivity
score: 1.5211955, Bioorganic & Medicinal Chemistry Letters, 2004, Bodtke, Anja et. al.
2-(Acyloxy)ethylphosphonate analogues of prenyl pyrophosphates: synthesis and biological characterization
score: 1.5211225, Bioorganic & Medicinal Chemistry, 2000, Cermak, Diana M. et. al.
Palladium-catalyzed synthesis of [ E]-6-(2-acylvinyl)uracils and [ E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils—their antiviral and cytotoxic activities
score: 1.520971, Bioorganic & Medicinal Chemistry, 1997, Kundu, Nitya G.; Das, Palas; Balzarini, Jan; De Clercq, Erik
A novel biotinylated diazirinyl ceramide analogue for photoaffinity labeling
score: 1.5209359, Bioorganic & Medicinal Chemistry Letters, 2008, Hashimoto, Makoto; Hatanaka, Yasumaru
2,5-Diarylisothiazolone: novel inhibitors of cytokine-induced cartilage destruction
score: 1.5207892, Bioorganic & Medicinal Chemistry, 1996, Wright, Stephen W. et. al.
Unify QSAR approach to antimicrobials. Part 1: Predicting antifungal activity against different species
score: 1.5207751, Bioorganic & Medicinal Chemistry, 2006, González-Díaz, Humberto et. al.
Design, synthesis and glutathione peroxidase-Like properties of ovothiol-Derived diselenides
score: 1.5205539, Bioorganic & Medicinal Chemistry, 2003, Bailly, Fabrice; Azaroual, Nathalie; Bernier, Jean-Luc
A novel tetrahydrobenzoangelicin with dark and photo biological activity
score: 1.5204921, Bioorganic & Medicinal Chemistry, 2012, Dalla Via, Lisa et. al.
A novel tetrahydrobenzoangelicin with dark and photo biological activity
score: 1.5204921, Bioorganic & Medicinal Chemistry, 2012, Dalla Via, Lisa et. al.
A novel tetrahydrobenzoangelicin with dark and photo biological activity
score: 1.5204921, Bioorganic & Medicinal Chemistry, 2012, Dalla Via, Lisa et. al.
In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens.
score: 1.5204705, Antimicrobial agents and chemotherapy, 2011, Pucci, Michael J et. al.
Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites
score: 1.5203693, Bioorganic & Medicinal Chemistry, 2005, De Angelis, Meri et. al.
9-Oxime-3-ketolides: Modification at the C-11,12-diol moiety and antibacterial activities against key respiratory pathogens
score: 1.5202144, Bioorganic & Medicinal Chemistry, 2005, Nomura, Takashi et. al.
N4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: Cytotoxicity against human tumor cells, structure–activity relationship studies and investigation on the mechanism of action
score: 1.5200302, Bioorganic & Medicinal Chemistry, 2012, Soares, Marcella A. et. al.
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance
score: 1.5199414, Bioorganic & Medicinal Chemistry Letters, 2012, Furber, Mark et. al.
Synthesis and antioxidant activities of 2-oxo-quinoline-3-carbaldehyde Schiff-base derivatives
score: 1.5198582, Bioorganic & Medicinal Chemistry Letters, 2013, Zhang, Ye et. al.
Chiral anthracene and anthrone templates as stereocontrolling elements in Diels–Alder/retro Diels–Alder sequences
score: 1.5198562, Bioorganic & Medicinal Chemistry, 2005, Burgess, Kerrie L. et. al.
Photoinduced DNA cleavage by anthracene based hydroxamic acids
score: 1.519641, Bioorganic & Medicinal Chemistry Letters, 2012, Chowdhury, Nilanjana; Dasgupta, Swagata; Pradeep Singh, N.D.
Photoinduced DNA cleavage by anthracene based hydroxamic acids
score: 1.519641, Bioorganic & Medicinal Chemistry Letters, 2012, Chowdhury, Nilanjana; Dasgupta, Swagata; Pradeep Singh, N.D.
Photoinduced DNA cleavage by anthracene based hydroxamic acids
score: 1.519641, Bioorganic & Medicinal Chemistry Letters, 2012, Chowdhury, Nilanjana; Dasgupta, Swagata; Pradeep Singh, N.D.
New water-soluble prodrugs of HIV protease inhibitors based on O→ N intramolecular acyl migration
score: 1.5196279, Bioorganic & Medicinal Chemistry, 2002, Hamada, Yoshio et. al.
Synthesis and structure–Activity relationships of 2-Amino-8-hydroxyadenines as orally active interferon inducing agents
score: 1.5195141, Bioorganic & Medicinal Chemistry, 2003, Kurimoto, Ayumu et. al.
Synthesis, Characterization and in vitro Anti-tumor Activities of Matrine Derivatives
score: 1.5192369, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lisheng et. al.
Azole derivatives of 1,4-benzothiazine as antifungal agents
score: 1.5190546, Bioorganic & Medicinal Chemistry, 1998, Fringuelli, Renata et. al.
Rational design, Synthesis and antiproliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold
score: 1.519032, European Journal of Medicinal Chemistry, 2012, Manera, Clementina et. al.
A comparative binding study of BIV Tat peptide against its TAR RNA duplex, RNA–DNA heteroduplex and DNA duplex
score: 1.5186822, Bioorganic & Medicinal Chemistry Letters, 2005, Tok, Jeffrey B.-H.; Bi, Lanrong
New potent C 2-Symmetric malaria plasmepsin I and II inhibitors
score: 1.5186814, Bioorganic & Medicinal Chemistry, 2003, Oscarsson, Karin et. al.
Design, Synthesis and Anticancer activity of Nitric oxide donating /Chalcone Hybrids
score: 1.5185093, European Journal of Medicinal Chemistry, 2012, Mourad, Mai A.E. et. al.
Synthesis of glycopeptides with phytoalexin elicitor activity — III. Syntheses of hexaglycosyl hexapeptides and a nonaglycosyl hexapeptide
score: 1.518467, Bioorganic & Medicinal Chemistry, 1996, Takeda, Tadahiro; Kanemitsu, Takuya; Ogihara, Yukio
SAR studies of brasilicardin A for immunosuppressive and cytotoxic activities
score: 1.5184268, Bioorganic & Medicinal Chemistry, 2005, Komatsu, Kazusei et. al.
Synthesis and Evaluation of Taxol–Folic Acid Conjugates as Targeted Antineoplastics † † See ref 1.
score: 1.5182928, Bioorganic & Medicinal Chemistry, 2002, Lee, Jae Wook; Lu, June Y; Low, P.S; Fuchs, P.L
Synthesis and biological evaluation of benzo[ d]isothiazole, benzothiazole and thiazole Schiff bases
score: 1.5182807, Bioorganic & Medicinal Chemistry, 2003, Vicini, Paola et. al.
The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product
score: 1.5181591, Bioorganic & Medicinal Chemistry Letters, 2012, Sivaramakrishnan, Santhosh et. al.
The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product
score: 1.5181591, Bioorganic & Medicinal Chemistry Letters, 2012, Sivaramakrishnan, Santhosh et. al.
The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product
score: 1.5181591, Bioorganic & Medicinal Chemistry Letters, 2012, Sivaramakrishnan, Santhosh et. al.
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid
score: 1.5181175, Bioorganic & Medicinal Chemistry Letters, 2012, Persch, Elke et. al.
Synthesis and anti-inflammatory evaluation of 9-phenoxyacridine and 4-phenoxyfuro[2,3- b]quinoline derivatives. Part 2
score: 1.5181105, Bioorganic & Medicinal Chemistry, 2003, Chen, Yeh-Long et. al.
Synthesis of fluorinated 1-(3-Morpholin-4-yl-phenyl)-Ethylamines
score: 1.5179368, Bioorganic & Medicinal Chemistry Letters, 2003, Wu, Yong-Jin et. al.
Design, synthesis, and biological evaluation of novel 4-alkylamino-1-hydroxymethylimidazo[1,2- a]quinoxalines as adenosine A 1 receptor antagonists
score: 1.5179116, Bioorganic & Medicinal Chemistry, 2004, Liu, Chun-He et. al.
Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin
score: 1.5178802, Bioorganic & Medicinal Chemistry Letters, 2006, Qiu, Wen-Wei et. al.
Structural chemistry and In vitro antitubercular activity of acetylpyridine benzoyl hydrazone and its copper complex against Mycobacterium smegmatis
score: 1.5177732, Bioorganic & Medicinal Chemistry Letters, 2003, Patole, Jayendra et. al.
Synthesis of compounds with antiproliferative activity as analogues of prenylated natural products existing in Brazilian propolis
score: 1.5175709, European Journal of Medicinal Chemistry, 2006, Pisco, Laura et. al.
Indolizines as novel potent inhibitors of 15-Lipoxygenase
score: 1.5175683, Bioorganic & Medicinal Chemistry, 2003, Gundersen, Lise-Lotte et. al.
Synthesis and enzymatic activation of N-[ N α-(4-amino-4-deoxypteroyl)- N δ-hemiphthaloyl- l-ornithiny]- l-phenylalanine, a candidate for antibody-directed enzyme prodrug therapy (ADEPT)
score: 1.5175225, Bioorganic & Medicinal Chemistry, 2002, Wright, Joel E; Rosowsky, Andre
Synthesis, molecular structure, and in vitro antitumor activity of new 4-chloro-2-mercaptobenzenesulfonamide derivatives
score: 1.5175198, European Journal of Medicinal Chemistry, 2005, Sławiński, Jarosław; Gdaniec, Maria
Simultaneous binding of mouse monoclonal antibody and streptavidin to heterobifunctional dendritic l-lysine core bearing T-antigen tumor marker and biotin
score: 1.5174504, Bioorganic & Medicinal Chemistry, 2001, Baek, Myung-Gi; Roy, René
Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases
score: 1.5173611, Bioorganic & Medicinal Chemistry, 2000, Yokomatsu, Tsutomu et. al.
Syntheses of 1,2-diamino and 1,2-aminoalcohol derivatives in the piperidine and pyrrolidine series as anti-amnesic agents
score: 1.517209, Bioorganic & Medicinal Chemistry, 1999, Zhao, Shikai et. al.
Synthesis and antibiofilm activity of marine natural product-based 4-thiazolidinones derivatives
score: 1.5172025, Bioorganic & Medicinal Chemistry Letters, 2012, Rane, Rajesh A.; Sahu, Niteshkumar U.; Shah, Chetan P.
Synthesis and antibiofilm activity of marine natural product-based 4-thiazolidinones derivatives
score: 1.5172025, Bioorganic & Medicinal Chemistry Letters, 2012, Rane, Rajesh A.; Sahu, Niteshkumar U.; Shah, Chetan P.
Alstiphyllanines I–O, ajmaline type alkaloids from Alstonia macrophylla showing vasorelaxant activity
score: 1.5169276, Bioorganic & Medicinal Chemistry, 2012, Arai, Hiroko et. al.
Alstiphyllanines I–O, ajmaline type alkaloids from Alstonia macrophylla showing vasorelaxant activity
score: 1.5169276, Bioorganic & Medicinal Chemistry, 2012, Arai, Hiroko et. al.
Alstiphyllanines I–O, ajmaline type alkaloids from Alstonia macrophylla showing vasorelaxant activity
score: 1.5169276, Bioorganic & Medicinal Chemistry, 2012, Arai, Hiroko et. al.
Synthesis and antibacterial activity of some new 1-heteroaryl-5-amino-4-phenyl-3-trifluoromethylpyrazoles
score: 1.516913, European Journal of Medicinal Chemistry, 2005, Kumar, Vinod et. al.
Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter
score: 1.5164057, Bioorganic & Medicinal Chemistry Letters, 2012, Qiao, Hongwen et. al.
Enzymatic synthesis of sialyl-Lewis a-libraries with two non-natural monosaccharide units
score: 1.5163789, Bioorganic & Medicinal Chemistry Letters, 1998, Baisch, Gabi et. al.
Palladium(II) complexes with R 2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R 2eddip esters and palladium(II) complexes
score: 1.5162164, European Journal of Medicinal Chemistry, 2009, Zmejkovski, Bojana B. et. al.
A Novel Approach towards Studying Non-Genotoxic Enediynes as Potential Anticancer Therapeutics
score: 1.5160886, Bioorganic & Medicinal Chemistry, 2002, Hakimelahi, Gholam Hossein et. al.
Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives
score: 1.5160054, Bioorganic & Medicinal Chemistry, 2005, Khalafi-Nezhad, A. et. al.
Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.
score: 1.5160047, Antimicrobial agents and chemotherapy, 2011, Scarth, Brian J et. al.
Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type K ATP-channel openers
score: 1.5159969, Bioorganic & Medicinal Chemistry, 2005, Carosati, Emanuele et. al.
Discovery of novel sulfonated small molecules that inhibit vascular tube formation
score: 1.5159924, Bioorganic & Medicinal Chemistry Letters, 2012, Raman, Karthik et. al.
Discovery of novel sulfonated small molecules that inhibit vascular tube formation
score: 1.5159924, Bioorganic & Medicinal Chemistry Letters, 2012, Raman, Karthik et. al.
Discovery of novel sulfonated small molecules that inhibit vascular tube formation
score: 1.5159924, Bioorganic & Medicinal Chemistry Letters, 2012, Raman, Karthik et. al.
Synthesis and antitumor activity of novel 2-amino-4-(3,5,5-trimethyl-2-pyrazolino)-1,3,5-triazine derivatives
score: 1.5159724, European Journal of Medicinal Chemistry, 2002, Brzozowski, Z; Sączewski, F
Perturbing pro-survival proteins using quinoxaline derivatives: A structure–activity relationship study
score: 1.5159642, Bioorganic & Medicinal Chemistry, 2012, Rajule, Rajkumar et. al.
Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD38
score: 1.515901, Bioorganic & Medicinal Chemistry Letters, 2003, Hara-Yokoyama, Miki et. al.
Quantitative structure–Activity studies of octopaminergic agonists and antagonists against nervous system of Locusta migratoria
score: 1.5158802, Bioorganic & Medicinal Chemistry, 1998, Hirashima, Akinori et. al.
Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe
score: 1.515856, Bioorganic & Medicinal Chemistry, 2005, Malolanarasimhan, Krishnan et. al.
Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.
score: 1.5158312, Nature chemical biology, 2011, Stelzer, Andrew C et. al.
Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia
score: 1.5157605, Bioorganic & Medicinal Chemistry, 2004, Kuo, Ping-Chung et. al.
Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope
score: 1.5156873, Bioorganic & Medicinal Chemistry Letters, 2009, Simerska, Pavla; Lu, Hao; Toth, Istvan
Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: synthesis, antitumor activity and molecular modeling investigations
score: 1.5156156, European Journal of Medicinal Chemistry, 2004, Zink, Mario; Lanig, Harald; Troschütz, Reinhard
Application quantum and physico chemical molecular descriptors utilizing principal components to study mode of anticoagulant activity of pyridyl chromen-2-one derivatives
score: 1.5155725, Bioorganic & Medicinal Chemistry, 2009, Bhatia, M.S. et. al.
Design and synthesis of novel antimicrobial pseudopeptides with selective membrane-perturbation activity
score: 1.5154783, Bioorganic & Medicinal Chemistry, 2000, Lee, Keun-Hyeung; Oh, Jong-Eun
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases
score: 1.5151992, Bioorganic & Medicinal Chemistry, 2006, Gu, Wenxin et. al.
Wake promoting agents: Search for next generation modafinil, lessons learned: Part III
score: 1.5151539, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Wake promoting agents: Search for next generation modafinil, lessons learned: Part III
score: 1.5151539, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Wake promoting agents: Search for next generation modafinil, lessons learned: Part III
score: 1.5151539, Bioorganic & Medicinal Chemistry Letters, 2012, Dunn, Derek et. al.
Guanidinium and aminoimidazolinium derivatives of N-(4-piperidyl)propanamides as potential ligands for μ opioid and I 2-imidazoline receptors: synthesis and pharmacological screening
score: 1.5150575, Bioorganic & Medicinal Chemistry, 2002, Montero, Ana et. al.
Pyrrolo[2,3- h]quinolinones: A new ring system with potent photoantiproliferative activity
score: 1.5149942, Bioorganic & Medicinal Chemistry, 2006, Barraja, Paola et. al.
Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein
score: 1.5147988, Bioorganic & Medicinal Chemistry Letters, 2013, Zentner, Isaac et. al.
Identification of novel small-Molecule Ulex europaeus I mimetics for targeted drug delivery
score: 1.5147081, Bioorganic & Medicinal Chemistry, 2003, Hamashin, Christa et. al.
Synthesis of amino acid derived seven-membered lactams by RCM and their evaluation against HIV protease
score: 1.514681, Bioorganic & Medicinal Chemistry, 2006, Zaman, Shazia; Campaner, Pietro; Abell, Andrew D.
Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor
score: 1.514648, Bioorganic & Medicinal Chemistry Letters, 2005, Bonnefous, Céline et. al.
Novel jadomycins: incorporation of non-natural and natural amino acids
score: 1.5146382, Bioorganic & Medicinal Chemistry Letters, 2005, Jakeman, David L. et. al.
TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates.
score: 1.5146269, Antimicrobial agents and chemotherapy, 2005, De Meyer, Sandra et. al.
Anticancer activity of small amphipathic β2,2-amino acid derivatives
score: 1.5145642, European Journal of Medicinal Chemistry, 2012, Hansen, Terkel et. al.
Synthesis and QSAR Studies in 2-( N-aryl- N-aroyl)amino-4,5-dihydrothiazole Derivatives as Potential Antithrombotic Agents
score: 1.5145032, Bioorganic & Medicinal Chemistry, 2001, Saxena, Anil K. et. al.
Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives
score: 1.5144832, Bioorganic & Medicinal Chemistry, 2005, Silva, Tania M.S. et. al.
Mutation of Cysteine-295 to Alanine in Secondary Alcohol Dehydrogenase from Thermoanaerobacter ethanolicus Affects the Enantioselectivity and Substrate Specificity of Ketone Reductions
score: 1.5139315, Bioorganic & Medicinal Chemistry, 2001, Heiss, Christian et. al.
Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach
score: 1.5139314, European Journal of Medicinal Chemistry, 2012, Aggarwal, Saurabh et. al.
Functional assay for shiga-like toxin via detection by antibody capture and multivalent galabiose binding
score: 1.5139106, Bioorganic & Medicinal Chemistry Letters, 2012, van Hattum, Hilde et. al.
Functional assay for shiga-like toxin via detection by antibody capture and multivalent galabiose binding
score: 1.5139106, Bioorganic & Medicinal Chemistry Letters, 2012, van Hattum, Hilde et. al.
Functional assay for shiga-like toxin via detection by antibody capture and multivalent galabiose binding
score: 1.5139106, Bioorganic & Medicinal Chemistry Letters, 2012, van Hattum, Hilde et. al.
Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors
score: 1.5138455, Bioorganic & Medicinal Chemistry, 2013, Zhao, Xueqing et. al.
Dipeptide-based highly potent doxorubicin antibody conjugates
score: 1.5138267, Bioorganic & Medicinal Chemistry Letters, 2006, Jeffrey, Scott C. et. al.
Synthesis of a ratiometric fluorescent peptide sensor for the highly selective detection of Cd2+
score: 1.5138019, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Yan et. al.
Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors
score: 1.5136764, European Journal of Medicinal Chemistry, 2012, Shi, Zhi-Hao et. al.
Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors
score: 1.5136764, European Journal of Medicinal Chemistry, 2012, Shi, Zhi-Hao et. al.
3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents
score: 1.5135743, Bioorganic & Medicinal Chemistry, 2012, Kelley, Cody et. al.
3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents
score: 1.5135743, Bioorganic & Medicinal Chemistry, 2012, Kelley, Cody et. al.
γ-(Monophenyl)phosphono glutamate analogues as mechanism-based inhibitors of γ-glutamyl transpeptidase
score: 1.5135492, Bioorganic & Medicinal Chemistry, 2006, Han, Liyou et. al.
New α-( N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity
score: 1.5134496, European Journal of Medicinal Chemistry, 2004, Savini, Luisa et. al.
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes
score: 1.5134287, European Journal of Medicinal Chemistry, 2012, Ferraz, Karina S.O. et. al.
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes
score: 1.5134287, European Journal of Medicinal Chemistry, 2012, Ferraz, Karina S.O. et. al.
Pharmacophore identification and bioactivity prediction for triaminotriazine derivatives by electron conformational-genetic algorithm QSAR method
score: 1.513426, European Journal of Medicinal Chemistry, 2010, Sarıpınar, Emin; Geçen, Nazmiye; Şahin, Kader; Yanmaz, Ersin
DNA-Cleavage studies on N-substituted monocyclic enediynes: enhancement of potency by incorporation of intercalating or electron poor aromatic ring and subsequent design of a novel phototriggerable acyclic enediyne
score: 1.5133989, Bioorganic & Medicinal Chemistry Letters, 2000, Basak, Amit et. al.
Thieno[3,2-b]thiophene-2-carboxylic Acid Derivatives as GPR35 Agonists
score: 1.513369, Bioorganic & Medicinal Chemistry Letters, 2012, Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir.
score: 1.5132569, Antimicrobial agents and chemotherapy, 2004, Ray, Adrian S; Olson, Loren; Fridland, Arnold
Novel K540N mutation in Plasmodium falciparum dihydropteroate synthetase confers a lower level of sulfa drug resistance than does a K540E mutation.
score: 1.5132028, Antimicrobial agents and chemotherapy, 2011, Lumb, Vanshika; Sharma, Yagya D
Application of QSAR analysis to organic anion transporting polypeptide 1a5 (Oatp1a5) substrates
score: 1.513018, Bioorganic & Medicinal Chemistry, 2005, Yarim, Mine et. al.
A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins
score: 1.5129462, Bioorganic & Medicinal Chemistry Letters, 2010, Leggans, Erick K. et. al.
Synthesis and antimicrobial evaluation of l-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone
score: 1.5127478, European Journal of Medicinal Chemistry, 2012, Jin, Xin et. al.
Synthesis and antimicrobial evaluation of l-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone
score: 1.5127478, European Journal of Medicinal Chemistry, 2012, Jin, Xin et. al.
Synthesis, biological activity and structure–activity relationship of endomorphin-1/substance P derivatives
score: 1.5126984, Bioorganic & Medicinal Chemistry, 2012, Varamini, Pegah et. al.
Synthesis, biological activity and structure–activity relationship of endomorphin-1/substance P derivatives
score: 1.5126984, Bioorganic & Medicinal Chemistry, 2012, Varamini, Pegah et. al.
Structure-activity Relationship Studies of Naphthol AS-E and Its Derivatives as Anticancer Agents by Inhibiting CREB-mediated Gene Transcription
score: 1.512688, Bioorganic & Medicinal Chemistry, 2012, Li, Bingbing X.; Yamanaka, Kinrin; Xiao, Xiangshu
Synthesis of 4-methylcoumarin derivatives containing 4,5-dihydropyrazole moiety to scavenge radicals and to protect DNA
score: 1.5126785, European Journal of Medicinal Chemistry, 2012, Xiao, Chuan et. al.
Synthesis of 4-methylcoumarin derivatives containing 4,5-dihydropyrazole moiety to scavenge radicals and to protect DNA
score: 1.5126785, European Journal of Medicinal Chemistry, 2012, Xiao, Chuan et. al.
Synthesis of 4-methylcoumarin derivatives containing 4,5-dihydropyrazole moiety to scavenge radicals and to protect DNA
score: 1.5126785, European Journal of Medicinal Chemistry, 2012, Xiao, Chuan et. al.
Analogues of N-terminal truncated synthetic peptide fragments derived from RANTES inhibit HIV-1 infectivity
score: 1.51245, Bioorganic & Medicinal Chemistry Letters, 2006, Ramnarine, Emabelle J. et. al.
Comparative quantitative structure–activity study of radical scavengers
score: 1.5119167, Bioorganic & Medicinal Chemistry, 2000, Vajragupta, Opa; Boonchoong, Preecha; Wongkrajang, Yuvadee
Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activities
score: 1.51175, Bioorganic & Medicinal Chemistry Letters, 2012, Lalut, Julien et. al.
Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activities
score: 1.51175, Bioorganic & Medicinal Chemistry Letters, 2012, Lalut, Julien et. al.
3,5-Dibenzoyl-1,4-dihydropyridines: Synthesis and MDR Reversal in Tumor Cells
score: 1.5117033, Bioorganic & Medicinal Chemistry, 2002, Kawase, Masami et. al.
Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives
score: 1.5116171, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Taejung et. al.
Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives
score: 1.5116171, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Taejung et. al.
Stereoselective synthesis of alpinoid-C and its analogues and study of their cytotoxic activity against cancer cell lines
score: 1.5115559, Bioorganic & Medicinal Chemistry Letters, 2012, Purushotham Reddy, S. et. al.
Stereoselective synthesis of alpinoid-C and its analogues and study of their cytotoxic activity against cancer cell lines
score: 1.5115559, Bioorganic & Medicinal Chemistry Letters, 2012, Purushotham Reddy, S. et. al.
Stereoselective synthesis of alpinoid-C and its analogues and study of their cytotoxic activity against cancer cell lines
score: 1.5115559, Bioorganic & Medicinal Chemistry Letters, 2012, Purushotham Reddy, S. et. al.
N-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide.
score: 1.5115426, Antimicrobial agents and chemotherapy, 2001, Chicharro, C; Granata, C; Lozano, R; Andreu, D; Rivas, L
Enhancement of fluorescence quenching and exciplex formation in DNA major groove by double incorporation of modified fluorescent deoxyuridines
score: 1.5114355, Bioorganic & Medicinal Chemistry Letters, 2012, Tanaka, Makiko; Oguma, Kazuhiro; Saito, Yoshio; Saito, Isao
Enhancement of fluorescence quenching and exciplex formation in DNA major groove by double incorporation of modified fluorescent deoxyuridines
score: 1.5114355, Bioorganic & Medicinal Chemistry Letters, 2012, Tanaka, Makiko; Oguma, Kazuhiro; Saito, Yoshio; Saito, Isao
Enhancement of fluorescence quenching and exciplex formation in DNA major groove by double incorporation of modified fluorescent deoxyuridines
score: 1.5114355, Bioorganic & Medicinal Chemistry Letters, 2012, Tanaka, Makiko; Oguma, Kazuhiro; Saito, Yoshio; Saito, Isao
Synthesis of a library of benzoindolizines using poly(ethylene glycol) as soluble support
score: 1.5114317, Bioorganic & Medicinal Chemistry Letters, 2005, Yue, Guizhou et. al.
Formation of 4,4′-dimethoxytrityl- C-phosphonate oligonucleotides
score: 1.5111677, Bioorganic & Medicinal Chemistry Letters, 2004, Capaldi, Daniel C. et. al.
Synthesis of nitrile derivatives of estrogens
score: 1.5110353, Bioorganic & Medicinal Chemistry Letters, 2002, Ali, Hasrat; van Lier, Johan E
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase
score: 1.5108939, Bioorganic & Medicinal Chemistry, 2013, Catto, Marco et. al.
Synthesis of perylene bisimide-centered glycodendrimer and its interactions with concanavalin A
score: 1.5107925, Bioorganic & Medicinal Chemistry Letters, 2013, Wang, Ke-Rang et. al.
Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides
score: 1.51072, Bioorganic & Medicinal Chemistry, 2006, Sriram, Dharmarajan et. al.
Rationally designed cyclic analogues of Luteinizing Hormone – Releasing Hormone: Enhanced enzymatic stability and biological properties
score: 1.5106698, European Journal of Medicinal Chemistry, 2012, Laimou, Despina et. al.
Atom-Based Enumeration: New Eribulin Analogues with Low Susceptibility to P-Glycoprotein-Mediated Drug Efflux
score: 1.5106529, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Melvin J.; Zheng, Wanjun; Tendyke, Karen
Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis
score: 1.5105891, Bioorganic & Medicinal Chemistry Letters, 2012, Shen, Tao et. al.
Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis
score: 1.5105891, Bioorganic & Medicinal Chemistry Letters, 2012, Shen, Tao et. al.
Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis
score: 1.5105891, Bioorganic & Medicinal Chemistry Letters, 2012, Shen, Tao et. al.
Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes
score: 1.5103809, Bioorganic & Medicinal Chemistry, 2012, Kvasnica, Miroslav et. al.
Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes
score: 1.5103809, Bioorganic & Medicinal Chemistry, 2012, Kvasnica, Miroslav et. al.
Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes
score: 1.5103809, Bioorganic & Medicinal Chemistry, 2012, Kvasnica, Miroslav et. al.
Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V
score: 1.5103346, European Journal of Medicinal Chemistry, 2012, Marques, Emerson F. et. al.
Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V
score: 1.5103346, European Journal of Medicinal Chemistry, 2012, Marques, Emerson F. et. al.
Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V
score: 1.5103346, European Journal of Medicinal Chemistry, 2012, Marques, Emerson F. et. al.
Synthesis of MRI contrast agents derived from DOTAM-Gly- l-Phe-OH incorporating a disulfide bridge: Conjugation to a cell penetrating peptide and preparation of a dimeric agent
score: 1.5102144, Bioorganic & Medicinal Chemistry Letters, 2010, Suchý, Mojmír et. al.
Synthesis, characterisation and cytotoxicity of chloro derivatives of prenylnaphthohydroquinone
score: 1.5101663, Bioorganic & Medicinal Chemistry, 2005, Molinari, Aurora et. al.
Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones)
score: 1.5100605, Bioorganic & Medicinal Chemistry, 1998, Romo, Daniel et. al.
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani
score: 1.5099003, Bioorganic & Medicinal Chemistry Letters, 2012, Carballeira, Néstor M. et. al.
Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate
score: 1.5097198, Bioorganic & Medicinal Chemistry, 2005, Wang, Yuqiang; Li, Lianfa; Jiang, Wei; Larrick, James W.
Facile synthesis of 7-amino-4-carbamoylmethylcoumarin (ACC)-containing solid supports and Their corresponding fluorogenic protease substrates
score: 1.5094829, Bioorganic & Medicinal Chemistry Letters, 2003, Zhu, Qing; Li, Dong B; Uttamchandani, Mahesh; Yao, Shao Q
Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture
score: 1.5094269, Bioorganic & Medicinal Chemistry, 2006, Annedi, Subhash C. et. al.
Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071.
score: 1.5092584, Antimicrobial agents and chemotherapy, 1998, Tai, C Y et. al.
Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials
score: 1.5092533, European Journal of Medicinal Chemistry, 2006, Swamy, S. Nanjunda et. al.
Stereoselective synthesis of nicotinamide β-riboside and nucleoside analogs
score: 1.5092345, Bioorganic & Medicinal Chemistry Letters, 2004, Franchetti, Palmarisa et. al.
New synthetic heparin mimetics able to inhibit thrombin and factor Xa
score: 1.509091, Bioorganic & Medicinal Chemistry Letters, 1999, Petitou, Maurice et. al.
Glycosidation of alkylamino-alkan-1-ol. A simple and convenient synthesis of glycosylated cationic lipids
score: 1.5089102, Bioorganic & Medicinal Chemistry Letters, 2002, Jacopin, Christophe et. al.
Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine
score: 1.5088808, Bioorganic & Medicinal Chemistry Letters, 2007, Mercer, Susan L. et. al.
Proteomic signature of fatty acid biosynthesis inhibition available for in vivo mechanism-of-action studies.
score: 1.5088422, Antimicrobial agents and chemotherapy, 2011, Wenzel, Michaela et. al.
Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino
score: 1.508702, Bioorganic & Medicinal Chemistry, 2005, Oh, Hyun-Mi et. al.
Design, synthesis and evaluation of N-(substituted benzothiazol-2-yl)amides as anticonvulsant and neuroprotective
score: 1.5084477, European Journal of Medicinal Chemistry, 2012, Hassan, Mohd. Zaheen; Khan, Suroor A.; Amir, Mohd.
Design, synthesis and evaluation of N-(substituted benzothiazol-2-yl)amides as anticonvulsant and neuroprotective
score: 1.5084477, European Journal of Medicinal Chemistry, 2012, Hassan, Mohd. Zaheen; Khan, Suroor A.; Amir, Mohd.
Coumarin 1,4-Dihydropyridine Derivatives
score: 1.5084163, Bioorganic & Medicinal Chemistry, 1998, Valenti, P.; Rampa, A.; Budriesi, R.; Bisi, A.; Chiarini, A.
Synthesis and preliminary analysis of a P-glycoprotein-specific [ 3H]-benzophenone photoaffinity label based on (−)-stipiamide
score: 1.5084097, Bioorganic & Medicinal Chemistry Letters, 2000, Andrus, Merritt B et. al.
Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives
score: 1.5083944, Bioorganic & Medicinal Chemistry, 2006, Huang, Li; Ho, Phong; Lee, Kuo-Hsiung; Chen, Chin-Ho
Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2
score: 1.5083315, Bioorganic & Medicinal Chemistry Letters, 2000, Walker, Clive V et. al.
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: Synthesis and evaluation of anti-infective, β-hematin inhibition and cytotoxic activities
score: 1.508245, European Journal of Medicinal Chemistry, 2012, Kaur, Kirandeep et. al.
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata
score: 1.5080736, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Yunjiang; Bowden, Bruce F.; Kapoor, Vimal
Novel cyano- and amidino-substituted derivatives of thieno[2,3- b]- and thieno[3,2- b]thiophene-2-carboxanilides and thieno[3′,2′:4,5]thieno- and thieno[2′,3′:4,5]thieno [2,3- c]quinolones: Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation
score: 1.507949, Bioorganic & Medicinal Chemistry, 2006, Jarak, Ivana et. al.
2-Arylpyrazolo[1,5- a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands
score: 1.5077375, Bioorganic & Medicinal Chemistry, 2001, Selleri, Silvia et. al.
Resistance to human immunodeficiency virus type 1 protease inhibitors.
score: 1.5077351, Antimicrobial agents and chemotherapy, 1998, Boden, D; Markowitz, M
Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening
score: 1.507703, Bioorganic & Medicinal Chemistry Letters, 2012, Geldenhuys, Werner J.; Talasila, Phani K.; Sadana, Prabodh
Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide
score: 1.5076172, Bioorganic & Medicinal Chemistry, 2005, Sano, Hiroko et. al.
Armeniaspiroles, a new class of antibacterials: antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A
score: 1.5073931, Bioorganic & Medicinal Chemistry Letters, 2012, Couturier, Cédric et. al.
Rational design, synthesis and biological evaluation of thiadiazinoacridines: A new class of antitumor agents
score: 1.5073748, Bioorganic & Medicinal Chemistry, 2003, Antonini, Ippolito et. al.
Interstrand photocrosslinking of DNA via p-carbamoylvinyl phenol nucleoside
score: 1.507207, Bioorganic & Medicinal Chemistry Letters, 2005, Yoshimura, Yoshinaga; Ito, Yoshiaki; Fujimoto, Kenzo
Synthesis and structure–Activity relationships of a new set of 1,2,4-triazolo[4,3- a]quinoxalin-1-one derivatives as adenosine receptor antagonists
score: 1.5070056, Bioorganic & Medicinal Chemistry, 2003, Colotta, Vittoria et. al.
Discovery of potent antimicrobial peptide analogs of Ixosin-B
score: 1.5068978, Bioorganic & Medicinal Chemistry Letters, 2012, Lung, Feng-Di T. et. al.
Discovery of potent antimicrobial peptide analogs of Ixosin-B
score: 1.5068978, Bioorganic & Medicinal Chemistry Letters, 2012, Lung, Feng-Di T. et. al.
Discovery of potent antimicrobial peptide analogs of Ixosin-B
score: 1.5068978, Bioorganic & Medicinal Chemistry Letters, 2012, Lung, Feng-Di T. et. al.
Controllable selective synthesis of a polymerizable prodrug of cytarabine by enzymatic and chemical methods
score: 1.5067802, Bioorganic & Medicinal Chemistry Letters, 2005, Wang, Na; Chen, Zhi Chun; Lu, De Shui; Lin, Xian Fu
Synthesis of a major mitomycin C DNA adduct via a triaminomitosene
score: 1.5066974, Bioorganic & Medicinal Chemistry Letters, 2012, Champeil, Elise et. al.
Synthesis of a major mitomycin C DNA adduct via a triaminomitosene
score: 1.5066974, Bioorganic & Medicinal Chemistry Letters, 2012, Champeil, Elise et. al.
Synthesis of a major mitomycin C DNA adduct via a triaminomitosene
score: 1.5066974, Bioorganic & Medicinal Chemistry Letters, 2012, Champeil, Elise et. al.
Influence of stereoisomer of dispiro-1,2,4,5-tetraoxanes on their binding mode with heme and on antimalarial activity: molecular docking studies
score: 1.5066293, Bioorganic & Medicinal Chemistry, 2004, Tonmunphean, Somsak et. al.
Synthesis and antiproliferative evaluation of some new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine
score: 1.5065028, European Journal of Medicinal Chemistry, 2012, Racané, Livio et. al.
Synthesis and antitubercular activities of bis-glycosylated diamino alcohols
score: 1.5064198, Bioorganic & Medicinal Chemistry, 2005, Tripathi, R.P. et. al.
Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors
score: 1.5063531, European Journal of Medicinal Chemistry, 2012, Makatini, Maya M. et. al.
Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors
score: 1.5063531, European Journal of Medicinal Chemistry, 2012, Makatini, Maya M. et. al.
An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol
score: 1.5062867, Bioorganic & Medicinal Chemistry Letters, 2012, Beattie, David et. al.
Synthesis and melanin biosynthesis inhibitory activity of (±)-terrein produced by Penicillium sp. 20135
score: 1.5062703, Bioorganic & Medicinal Chemistry Letters, 2005, Lee, Sangku et. al.
Synthesis and antibacterial activity of littorachalcone and related diphenyl ethers
score: 1.5061538, Bioorganic & Medicinal Chemistry Letters, 2008, Kraus, George A. et. al.
Detection of galectin-3 by novel peptidic photoprobes
score: 1.5061341, Bioorganic & Medicinal Chemistry Letters, 2007, van Scherpenzeel, Monique et. al.
Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site
score: 1.5061104, Bioorganic & Medicinal Chemistry Letters, 2008, Torbeev, Vladimir Yu. et. al.
Reprint of “Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site” [Bioorg. Med. Chem. Lett. 18 (2008) 4554-4557]
score: 1.5061104, Bioorganic & Medicinal Chemistry Letters, 2008, Torbeev, Vladimir Yu. et. al.
N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration
score: 1.505979, Bioorganic & Medicinal Chemistry Letters, 2012, Wei, Zhongyong et. al.
Synthesis of β-substituted cationic porphyrins and their interactions with DNA
score: 1.5058494, Bioorganic & Medicinal Chemistry Letters, 2003, Chen, Bo et. al.
Indole-5-phenylcarbamate derivatives as human non-pancreatic secretory phospholipase A2 inhibitor
score: 1.5057395, Bioorganic & Medicinal Chemistry Letters, 2005, Liu, Ying et. al.
Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor
score: 1.5055896, Bioorganic & Medicinal Chemistry, 2012, Komiya, Masafumi et. al.
Efficient syntheses of chiral myo-inositol derivatives—key intermediates in glycosylphosphatidylinositol (GPI) syntheses
score: 1.505577, Bioorganic & Medicinal Chemistry Letters, 2009, Yu, Fei; Guo, Zhongwu
Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity
score: 1.5055061, Bioorganic & Medicinal Chemistry, 2001, Pathak, Ashish K et. al.
Characterization of poliovirus variants selected for resistance to the antiviral compound v-073.
score: 1.5054712, Antimicrobial agents and chemotherapy, 2012, Liu, Hong-Mei et. al.
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata
score: 1.5054254, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Yunjiang; Bowden, Bruce F.; Kapoor, Vimal
Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M
score: 1.5051655, Bioorganic & Medicinal Chemistry, 1999, Dallanoce, Clelia et. al.
Stereoselective Synthesis of Ψ[CH 2O] Pseudodipeptides and Conformational Analysis of a PheΨ[CH 2O]Ala Containing Analogue of the Drug Desmopressin
score: 1.5049747, Bioorganic & Medicinal Chemistry Letters, 2002, Hedenström, Mattias et. al.
α-1- C-Octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease
score: 1.5048365, Bioorganic & Medicinal Chemistry, 2006, Yu, Liang et. al.
Three-dimensional pharmacophore hypotheses of octopamine/tyramine agonists which inhibit [1- 14C]acetate incorporation in Plodia interpunctella
score: 1.5047881, Bioorganic & Medicinal Chemistry, 2003, Hirashima, Akinori et. al.
Synthesis of 13C 7-labeled iodoacetanilide and application to quantitative analysis of peptides and a protein by isotope differential mass spectrometry
score: 1.5047703, Bioorganic & Medicinal Chemistry Letters, 2009, Niwayama, Satomi et. al.
Design, synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors
score: 1.5046654, Bioorganic & Medicinal Chemistry, 2013, Xie, Ruliang et. al.
Identification of bis-quindolines as new antiinfective agents
score: 1.504606, Bioorganic & Medicinal Chemistry, 2005, Mardenborough, Leroy G. et. al.
Efficacy of proton pump inhibitor drugs against Plasmodium falciparum in vitro and their probable pharmacophores.
score: 1.5043476, Antimicrobial agents and chemotherapy, 2002, Riel, Michael A et. al.
Azo-reductase activated budesodine prodrugs for colon targeting
score: 1.5042856, Bioorganic & Medicinal Chemistry Letters, 2012, Marquez Ruiz, Juan F. et. al.
Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ
score: 1.5042732, Bioorganic & Medicinal Chemistry, 2012, Cassel, Joel A. et. al.
Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ
score: 1.5042732, Bioorganic & Medicinal Chemistry, 2012, Cassel, Joel A. et. al.
Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ
score: 1.5042732, Bioorganic & Medicinal Chemistry, 2012, Cassel, Joel A. et. al.
Synthesis of N-(1-methyl-1H-indol-3-yl)methyleneamines and 3,3-diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones as potential antileishmanial agents
score: 1.5041917, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Girija S. et. al.
Crystal structures, antioxidation and DNA binding properties of Dy(III) complexes with Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxaldehyde and four aroylhydrazines
score: 1.5040067, European Journal of Medicinal Chemistry, 2009, Liu, Yong-chun; Yang, Zheng-yin
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione
score: 1.5039987, European Journal of Medicinal Chemistry, 2006, Conchon, Elisabeth et. al.
Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors
score: 1.503834, European Journal of Medicinal Chemistry, 2012, Loidreau, Yvonnick et. al.
A genetic algorithm optimized fuzzy neural network analysis of the affinity of inhibitors for HIV-1 protease
score: 1.5038337, Bioorganic & Medicinal Chemistry, 2008, Fabry-Asztalos, Levente et. al.
Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae
score: 1.5038272, Bioorganic & Medicinal Chemistry Letters, 2012, Nair, Jerald J. et. al.
Simple, fast and efficient synthesis of β–keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines
score: 1.5036027, Bioorganic & Medicinal Chemistry Letters, 2012, Venkat Ragavan, R. et. al.
Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica
score: 1.5034417, Bioorganic & Medicinal Chemistry Letters, 2012, Kato, Eisuke et. al.
Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry
score: 1.503302, European Journal of Medicinal Chemistry, 2012, Zhang, Yikai et. al.
Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry
score: 1.503302, European Journal of Medicinal Chemistry, 2012, Zhang, Yikai et. al.
Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol
score: 1.5032594, Bioorganic & Medicinal Chemistry Letters, 2005, Hand, Christine E.; Taylor, Nicholas J.; Honek, John F.
Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings.
score: 1.5031809, Antimicrobial agents and chemotherapy, 2012, Johnson, Todd J et. al.
Novel derivatives of methyl and ethyl 2-(4-oxo-8-aryl-2 H-3,4,6,7-tetrahydroimidazo[2,1- c][1,2,4]triazin-3-yl)acetates from biologically active 1-aryl-2-hydrazinoimidazolines: Synthesis, crystal structure and antiproliferative activity
score: 1.5031767, European Journal of Medicinal Chemistry, 2006, Sztanke, Krzysztof et. al.
An alternative synthesis of peptidyl α-keto-2-oxazolines
score: 1.5029492, Bioorganic & Medicinal Chemistry Letters, 1998, Dunn, Derek; Chatterjee, Sankar
Triterpenes from Alisma orientalis act as farnesoid X receptor agonists
score: 1.5029444, Bioorganic & Medicinal Chemistry Letters, 2012, Lin, Hsiang-Ru
Design and synthesis of a vialinin A analog with a potent inhibitory activity of TNF-α production and its transformation into a couple of bioprobes
score: 1.5027772, Bioorganic & Medicinal Chemistry Letters, 2012, Ye, Yue Qi et. al.
Synthesis, characterisation and cytotoxic properties of the N 1, N 4-diarylidene- S-methyl-thiosemicarbazone chelates with Fe(III) and Ni(II)
score: 1.5027289, European Journal of Medicinal Chemistry, 2007, Bal, Tülay et. al.
One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation
score: 1.5024826, European Journal of Medicinal Chemistry, 2012, Zhao, Pei-Liang et. al.
Disproportionation reaction of disulfides promoted by nitric oxide (NO) in the presence of oxygen
score: 1.5023412, Bioorganic & Medicinal Chemistry Letters, 1999, Itoh, Takashi; Tsutsumi, Nozomi; Ohsawa, Akio
Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives
score: 1.5023411, European Journal of Medicinal Chemistry, 2012, Hernández-Covarrubias, Carlos et. al.
In vitro cytotoxicity study on platinum (II) complexes with epoxysuccinates as leaving groups
score: 1.5022733, Bioorganic & Medicinal Chemistry Letters, 2007, Liu, Xia; Shen, Hong; Zhu, Haibin; Cui, Kai; Gou, Shaohua
Comparative molecular field analysis of some pyridazinone-containing α 1-Antagonists
score: 1.502079, Bioorganic & Medicinal Chemistry, 1999, Cinone, N. et. al.
Synthesis of new piperazine–pyridazinone derivatives and their binding affinity toward α 1-, α 2-adrenergic and 5-HT 1A serotoninergic receptors
score: 1.502037, Bioorganic & Medicinal Chemistry, 2006, Betti, Laura et. al.
Network pharmacology: the next paradigm in drug discovery.
score: 1.501924, Nature chemical biology, 2008, Hopkins, Andrew L
Amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins.
score: 1.5018953, Antimicrobial agents and chemotherapy, 2002, Hujer, Andrea M et. al.
Non-canonical regioisomerizations and a ‘Diels–Alderase’ are likely essential in the biosynthesis of Spiculoic acid A
score: 1.5016478, Bioorganic & Medicinal Chemistry Letters, 2012, Pinto, Atahualpa; Boddy, Christopher N.
Hole filling and library optimization: Application to commercially available fragment libraries
score: 1.50162, Bioorganic & Medicinal Chemistry, 2012, An, Yuling; Sherman, Woody; Dixon, Steven L.
Hole filling and library optimization: Application to commercially available fragment libraries
score: 1.50162, Bioorganic & Medicinal Chemistry, 2012, An, Yuling; Sherman, Woody; Dixon, Steven L.
Hole filling and library optimization: Application to commercially available fragment libraries
score: 1.50162, Bioorganic & Medicinal Chemistry, 2012, An, Yuling; Sherman, Woody; Dixon, Steven L.
Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity
score: 1.5015561, Bioorganic & Medicinal Chemistry, 2003, Hermoso, Alicia et. al.
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling
score: 1.5014583, Bioorganic & Medicinal Chemistry, 2006, Ishida, Junya et. al.
Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.
score: 1.5011617, Antimicrobial agents and chemotherapy, 2012, Papp-Wallace, Krisztina M et. al.
Softening the Rule of Five—where to draw the line?
score: 1.5011214, Bioorganic & Medicinal Chemistry, 2012, Petit, Joachim et. al.
Scabronine M, a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells from the fungus Sarcodon scabrosus
score: 1.5009791, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Li et. al.
Chemo-enzymatic synthesis of tetra- N-acetyl-chitotetraosyl allosamizoline
score: 1.5009676, Bioorganic & Medicinal Chemistry Letters, 2006, Huang, Gang-Liang et. al.
Synthesis and testing of azaglutamine derivatives as inhibitors of Hepatitis A Virus (HAV) 3C proteinase
score: 1.500767, Bioorganic & Medicinal Chemistry, 1999, Huang, Yanting; Malcolm, Bruce A; Vederas, John C
Optically active 2-benzyl-3-methanesulfinylpropanoic acid: Synthesis and evaluation as inhibitors for carboxypeptidase A
score: 1.500734, Bioorganic & Medicinal Chemistry, 2003, Jin, Jing-Yi; Tian, Guan Rong; Kim, Dong H
Novel inhibitors of the hepatitis C virus NS3 proteinase
score: 1.5006188, Bioorganic & Medicinal Chemistry Letters, 2005, Bennett, Frank et. al.
Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd( C 2, N-dmba)(Br)(tu)] (dmba = N, N-dimethylbenzylamine, tu = thiourea)
score: 1.500496, European Journal of Medicinal Chemistry, 2009, Moro, Antonio C. et. al.
Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)- N′-(5-nitro-1,3-thiazol-2-yl)urea ([ 11C]AR-A014418): A radiolabelled glycogen synthase kinase-3β specific inhibitor for PET studies
score: 1.5004821, Bioorganic & Medicinal Chemistry Letters, 2005, Vasdev, Neil et. al.
Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-Metastatic murine colon 26-L5 carcinoma cell line
score: 1.5001014, Bioorganic & Medicinal Chemistry, 2002, Nagaoka, Takema et. al.
Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists
score: 1.5000529, Bioorganic & Medicinal Chemistry, 2012, Xiao, Bin et. al.
Synthesis of chiral hydroxylated enones as potential anti-tumor agents
score: 1.5000131, Bioorganic & Medicinal Chemistry Letters, 2012, Shing, Tony K.M.; Wu, Ho T.; Kwok, H.F.; Lau, Clara B.S.
Synthesis of chiral hydroxylated enones as potential anti-tumor agents
score: 1.5000131, Bioorganic & Medicinal Chemistry Letters, 2012, Shing, Tony K.M.; Wu, Ho T.; Kwok, H.F.; Lau, Clara B.S.
Synthesis of chiral hydroxylated enones as potential anti-tumor agents
score: 1.5000131, Bioorganic & Medicinal Chemistry Letters, 2012, Shing, Tony K.M.; Wu, Ho T.; Kwok, H.F.; Lau, Clara B.S.
Toward a rational design of selective multi-trypanosomatid inhibitors: A computational docking study
score: 1.4999646, Bioorganic & Medicinal Chemistry Letters, 2006, Espinoza-Fonseca, L. Michel; Trujillo-Ferrara, José G.
Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis
score: 1.4998742, Bioorganic & Medicinal Chemistry, 2012, Manzoni, Leonardo et. al.
Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis
score: 1.4998742, Bioorganic & Medicinal Chemistry, 2012, Manzoni, Leonardo et. al.
Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors
score: 1.4997786, European Journal of Medicinal Chemistry, 2012, Loidreau, Yvonnick et. al.
Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability
score: 1.4997452, European Journal of Medicinal Chemistry, 2003, Kawanaka, Yasufumi et. al.
Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride ( 8018)
score: 1.4995979, Bioorganic & Medicinal Chemistry Letters, 2005, Han, Xiang-Yu et. al.
Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles
score: 1.4995376, Bioorganic & Medicinal Chemistry Letters, 2009, Milinkevich, Kristin A. et. al.
Solid-phase synthesis of backbone-modified DNA analogs by the boranophosphotriester method using new protecting groups for nucleobases
score: 1.499434, Bioorganic & Medicinal Chemistry Letters, 2008, Kawanaka, Toshihide et. al.
Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins
score: 1.4994255, Bioorganic & Medicinal Chemistry Letters, 2013, Zhang, Xiao-Shu et. al.
Novel 1,3-dicarbonyl compounds having 2(3 H)-benzazolonic heterocycles as PPARγ agonists
score: 1.4991771, Bioorganic & Medicinal Chemistry, 2006, Blanc-Delmas, Elodie et. al.
Enhanced activity or resistance of adenosine derivatives towards adenosine deaminase-catalyzed deamination: Influence of ribose modifications
score: 1.4991614, Bioorganic & Medicinal Chemistry Letters, 2009, Vistoli, Giulio et. al.
Determination of 6 s -trans conformation of retinal chromophore in sensory rhodopsin I and phoborhodopsin
score: 1.4991042, Bioorganic & Medicinal Chemistry Letters, 1998, Wada, Akimori et. al.
Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors
score: 1.4990601, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Liping et. al.
Key analogues of the tetrapeptide subunit of RA-VII and deoxybouvardin
score: 1.4989787, Bioorganic & Medicinal Chemistry, 1996, Boger, Dale L.; Zhou, Jiacheng
Synthesis, reactions and structure–activity relationships of 1-hydroxyspiro[2.5]cyclooct-4-en-3-ones: Illudin analogs with in vitro cytotoxic activity
score: 1.4988369, Bioorganic & Medicinal Chemistry, 2006, Bose, Gopal et. al.
Steroidal C-21 heteroaryl thioethers. Part 3: Pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids)
score: 1.498832, Bioorganic & Medicinal Chemistry Letters, 2012, Biju, Purakkattle et. al.
Steroidal C-21 heteroaryl thioethers. Part 3: Pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids)
score: 1.498832, Bioorganic & Medicinal Chemistry Letters, 2012, Biju, Purakkattle et. al.
New calcium antagonists: synthesis, X-ray analysis, and smooth muscle relaxing effect of 3-[ O-(Benzyl-substituted)-oximino-ethers]-hexahydroazepin-2,3-diones
score: 1.4987928, Bioorganic & Medicinal Chemistry, 1999, El From, Hayat et. al.
Sequence selective formation of 1, N 6-ethenoadenine in DNA by furan-conjugated probe
score: 1.4987685, Bioorganic & Medicinal Chemistry Letters, 2009, Kobori, Akio et. al.
Phenazine-1-carboxylic acid derivatives: Design, synthesis and biological evaluation against Rhizoctonia solani Kuhn
score: 1.4987023, Bioorganic & Medicinal Chemistry Letters, 2010, Ye, Long et. al.
Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors
score: 1.4984312, European Journal of Medicinal Chemistry, 2012, Krishnaiah, Maddeboina et. al.
Synthesis, biological evaluation, and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors
score: 1.4983379, Bioorganic & Medicinal Chemistry, 2012, You, Zhong-Lu et. al.
A novel tetrahydrobenzoangelicin with dark and photo biological activity
score: 1.4982852, Bioorganic & Medicinal Chemistry, 2012, Dalla Via, Lisa et. al.
Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy
score: 1.4981924, Bioorganic & Medicinal Chemistry, 2005, Johnsamuel, Jayaseharan et. al.
GAsDock: a new approach for rapid flexible docking based on an improved multi-population genetic algorithm
score: 1.4980227, Bioorganic & Medicinal Chemistry Letters, 2004, Li, Honglin et. al.
Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms
score: 1.4979175, Bioorganic & Medicinal Chemistry Letters, 2003, Li, Yonggang; Xu, Yufang; Qian, Xuhong; Qu, Baoyuan
An antitumor compound julibroside J 28 from Albizia julibrissin
score: 1.4978042, Bioorganic & Medicinal Chemistry Letters, 2005, Liang, Hong et. al.
Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives
score: 1.4977595, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Vijay S. et. al.
Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives
score: 1.4977595, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Vijay S. et. al.
Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives
score: 1.4977595, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Vijay S. et. al.
Design and synthesis of a selective EP4-receptor agonist. Part 4: practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist
score: 1.4976795, Bioorganic & Medicinal Chemistry, 2002, Maruyama, Toru et. al.
Identification of pharmacophore in bioactive metal complexes: Synthesis, spectroscopic characterization and application
score: 1.4976316, European Journal of Medicinal Chemistry, 2012, Mehrotra, Ripul et. al.
Design, synthesis, and conformational analysis of eight-membered cyclic peptidomimetics prepared using ring closing metathesis
score: 1.4976033, Bioorganic & Medicinal Chemistry, 2004, Creighton, Christopher J. et. al.
Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers
score: 1.4975284, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng; Miller, Marvin J.
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
score: 1.4974089, Antimicrobial agents and chemotherapy, 2011, Lansdon, Eric B et. al.
Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study
score: 1.4970971, European Journal of Medicinal Chemistry, 2012, Sharma, Aditya; Pan, Archana
Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents
score: 1.4970286, European Journal of Medicinal Chemistry, 2012, Jiang, Nan et. al.
Anticancer and radio-sensitizing evaluation of some new pyranothiazole-schiff bases bearing the biologically active sulfonamide moiety
score: 1.4969964, European Journal of Medicinal Chemistry, 2012, Ghorab, Mostafa M. et. al.
Preparation of alkylation agents for bulged DNA microenvironments
score: 1.4969896, Bioorganic & Medicinal Chemistry Letters, 2004, Fouad, Farid S. et. al.
Synthesis and biological evaluation of 1β-methylcarbapenems having guanidino moieties
score: 1.4968861, European Journal of Medicinal Chemistry, 2006, Oh, Chang-Hyun; Cho, Jung-Hyuck
Novel potent 5-HT 3 receptor ligands based on the pyrrolidone structure. effects of the quaternization of the basic nitrogen on the interaction with 5-HT 3 receptor
score: 1.4967714, Bioorganic & Medicinal Chemistry, 2002, Cappelli, Andrea et. al.
Cyclobutane carboxamide inhibitors of fungal melanin: biosynthesis and their evaluation as fungicides
score: 1.4967059, Bioorganic & Medicinal Chemistry, 2000, Jennings, Lee D. et. al.
Carbocyclic analogues of d-ribose-5-phosphate: Synthesis and behavior with 5-phosphoribosyl α-1-pyrophosphate synthetases
score: 1.4965445, Bioorganic & Medicinal Chemistry, 1996, Parry, Ronald J. et. al.
Discovery of non-peptidic P 2–P 3 butanediamide renin inhibitors with high oral efficacy
score: 1.496498, Bioorganic & Medicinal Chemistry, 1999, Simoneau, Bruno et. al.
Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-Hydroxy-17,17-trimethylene 9β-chloro PGF derivatives
score: 1.496268, Bioorganic & Medicinal Chemistry, 2002, Tani, Kousuke et. al.
Synthesis and biological activity of tricyclic analogues of 9-{[ cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine
score: 1.4962322, Bioorganic & Medicinal Chemistry, 2006, Ostrowski, Tomasz et. al.
Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071.
score: 1.4961994, Antimicrobial agents and chemotherapy, 1998, Li, W et. al.
Bis(5-hydroxy-2-hydroxymethyl-pyran-4-one-6-yl)methane: A novel ligand for the intracellular mobilisation of ferritin-bound iron
score: 1.4960624, Bioorganic & Medicinal Chemistry Letters, 1998, Fox, Raymond C.; Taylor, Paul D.
Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors
score: 1.4960325, Bioorganic & Medicinal Chemistry, 2012, Moran, Matthew D. et. al.
Fluorescent ligands for the histamine H 2 receptor: synthesis and preliminary characterization
score: 1.4958374, Bioorganic & Medicinal Chemistry, 2004, Malan, Sarel F. et. al.
Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors
score: 1.4958113, European Journal of Medicinal Chemistry, 2012, Shi, Zhi-Hao et. al.
Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain
score: 1.4957835, Bioorganic & Medicinal Chemistry, 2012, Akdemir, Atilla et. al.
Substituted 3-amino and/or 3-aminomethyl-3,4-dihydro-2 H-1-benzopyrans: synthesis and biological activity
score: 1.4957775, Bioorganic & Medicinal Chemistry, 2000, Comoy, Corinne et. al.
Synthetic approaches to 2-(4-hydroxy-7-chromanyl)benzoic acids as antagonists of leukotriene B 4
score: 1.4955696, Bioorganic & Medicinal Chemistry Letters, 1998, Chambers, R.J.; Koch, K.; Biggers, M.S.; Ramchandani, M.
Scintillation proximity assay for inhibitors of Escherichia coli MurG and, optionally, MraY.
score: 1.4953764, Antimicrobial agents and chemotherapy, 2005, Ravishankar, Sudha et. al.
Syntheses of tetrahydroxyazepanes from chiro-inositols and their evaluation as glycosidase inhibitors
score: 1.4952828, Bioorganic & Medicinal Chemistry, 2004, Painter, Gavin F; Eldridge, Paul J; Falshaw, Andrew
Customized versus universal scoring functions
score: 1.495156, Bioorganic & Medicinal Chemistry Letters, 2001, Logean, Antoine; Sette, Alessandro; Rognan, Didier
CP0569, A New Broad-Spectrum Injectable Carbapenem. Part 1: Synthesis and Structure–Activity Relationships
score: 1.4950755, Bioorganic & Medicinal Chemistry, 2003, Aihara, Kazuhiro et. al.
Scaffold composition and biological relevance of screening libraries.
score: 1.4950255, Nature chemical biology, 2007, Shelat, Anang A; Guy, R Kiplin
Unnatural base pairs mediate the site-specific incorporation of an unnatural hydrophobic component into RNA transcripts
score: 1.4947776, Bioorganic & Medicinal Chemistry Letters, 2004, Endo, Masayuki et. al.
Activity of pleconaril against enteroviruses.
score: 1.4946413, Antimicrobial agents and chemotherapy, 1999, Pevear, D C; Tull, T M; Seipel, M E; Groarke, J M
Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer–Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv
score: 1.4946383, Bioorganic & Medicinal Chemistry Letters, 2006, Snajdrova, Radka; Grogan, Gideon; Mihovilovic, Marko D.
Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl- l-prolyl- l-glutamic acid (GPE)
score: 1.4945193, Bioorganic & Medicinal Chemistry, 2005, Brimble, Margaret A. et. al.
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists
score: 1.4942909, European Journal of Medicinal Chemistry, 2003, Frølund, Bente et. al.
Chemical characterization and biological properties of NVC-422, a novel, stable N-chlorotaurine analog.
score: 1.494239, Antimicrobial agents and chemotherapy, 2011, Wang, Lu et. al.
A prodrug system for hydroxylamines based on esterase catalysis
score: 1.4941557, Bioorganic & Medicinal Chemistry Letters, 2005, Conejo-Garcia, Ana; Schofield, Christopher J.
Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases
score: 1.4938264, Bioorganic & Medicinal Chemistry Letters, 2012, Hoque, Md. Ashraful et. al.
Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases
score: 1.4938264, Bioorganic & Medicinal Chemistry Letters, 2012, Hoque, Md. Ashraful et. al.
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents
score: 1.4937585, European Journal of Medicinal Chemistry, 2012, Peng, Fei et. al.
Effect of C-ring modifications in benzo[ c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1
score: 1.4935249, Bioorganic & Medicinal Chemistry, 2001, Guarna, Antonio et. al.
Makomotindoline from Makomotake, Zizania latifolia infected with Ustilago esculenta
score: 1.4933731, Bioorganic & Medicinal Chemistry Letters, 2012, Suzuki, Tomohiro et. al.
Makomotindoline from Makomotake, Zizania latifolia infected with Ustilago esculenta
score: 1.4933731, Bioorganic & Medicinal Chemistry Letters, 2012, Suzuki, Tomohiro et. al.
Natural and synthetic G-quadruplex interactive berberine derivatives
score: 1.4932097, Bioorganic & Medicinal Chemistry Letters, 2006, Franceschin, Marco et. al.
Syntheses of photolabile novobiocin analogues
score: 1.4931886, Bioorganic & Medicinal Chemistry Letters, 2004, Shen, Gang; Yu, Xiao ming; Blagg, Brian S.J.
Affinity identification of δ-opioid receptors using latex nanoparticles
score: 1.4931705, Bioorganic & Medicinal Chemistry Letters, 2006, Hasegawa, Makoto et. al.
Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids
score: 1.4931274, European Journal of Medicinal Chemistry, 2012, Bortolini, Olga et. al.
Stereoselective synthesis of bio-hybrid amphiphiles of coumarin derivatives by Ugi–Mannich triazole randomization using copper catalyzed alkyne azide click chemistry
score: 1.4929648, Bioorganic & Medicinal Chemistry Letters, 2012, Pramitha, P.; Bahulayan, D.
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity
score: 1.4929288, European Journal of Medicinal Chemistry, 2012, Masurier, Nicolas et. al.
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity
score: 1.4929288, European Journal of Medicinal Chemistry, 2012, Masurier, Nicolas et. al.
Inhibitory effects of lapachol derivatives on epstein-barr virus activation
score: 1.4928176, Bioorganic & Medicinal Chemistry, 2003, Sacau, Elisa Pérez et. al.
Dihydropyrimidin-(2 H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents
score: 1.4927031, European Journal of Medicinal Chemistry, 2006, Stefani, Hélio A. et. al.
Synthesis and pharmacological investigation of azaphthalazinone human histamine H1 receptor antagonists
score: 1.4926598, Bioorganic & Medicinal Chemistry, 2012, Procopiou, Panayiotis A. et. al.
Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293.
score: 1.4926445, Antimicrobial agents and chemotherapy, 2002, Betz, Ulrich A K et. al.
Perylene Diimide G-Quadruplex DNA Binding Selectivity is Mediated by Ligand Aggregation
score: 1.4925739, Bioorganic & Medicinal Chemistry Letters, 2002, Kerwin, Sean M. et. al.
Bioactive conformation of a potent stromelysin inhibitor determined by X-nucleus filtered and multidimensional NMR spectroscopy
score: 1.4925374, Bioorganic & Medicinal Chemistry, 1997, Gonnella, Nina C. et. al.
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin
score: 1.4925239, Bioorganic & Medicinal Chemistry, 2006, Tangirala, Raghuram S. et. al.
Selective cross-linking to the adenine of the TA interrupting site within the triple helix
score: 1.4924787, Bioorganic & Medicinal Chemistry Letters, 2002, Nagatsugi, Fumi et. al.
Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity
score: 1.4924755, Bioorganic & Medicinal Chemistry Letters, 2012, Jia, Qiyan et. al.
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits
score: 1.4923801, Bioorganic & Medicinal Chemistry, 2012, Cho, Jung Keun et. al.
Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives
score: 1.492244, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Taejung et. al.
Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives
score: 1.492244, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Taejung et. al.
Synthesis of lipopolyhydroxylalkyleneamines for gene delivery
score: 1.4921599, Bioorganic & Medicinal Chemistry Letters, 2006, Li, Qun et. al.
Probing the receptor interactions of an H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands
score: 1.4921404, Bioorganic & Medicinal Chemistry, 2007, Barclay, Wendy S. et. al.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
score: 1.4921021, Bioorganic & Medicinal Chemistry, 2012, Nishida, Haruyuki et. al.
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065
score: 1.492004, Bioorganic & Medicinal Chemistry, 2003, Parrish, Jay P. et. al.
Synthesis of a coumarin-based europium complex for bioanalyte labeling
score: 1.4919821, Bioorganic & Medicinal Chemistry Letters, 2007, Féau, Clémentine; Klein, Emmanuel; Kerth, Paul; Lebeau, Luc
Binding of tryptamine analogs at h5-HT 1E receptors: a structure–affinity investigation
score: 1.4917478, Bioorganic & Medicinal Chemistry, 2004, Dukat, Małgorzata et. al.
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer
score: 1.4916821, Bioorganic & Medicinal Chemistry, 2006, Hwang, Dong Jin et. al.
Development and evaluation of multifunctional agents for potential treatment of Alzheimer’s disease: Application to a pyrimidine-2,4-diamine template
score: 1.4916771, Bioorganic & Medicinal Chemistry Letters, 2012, Mohamed, Tarek et. al.
Development and evaluation of multifunctional agents for potential treatment of Alzheimer’s disease: Application to a pyrimidine-2,4-diamine template
score: 1.4916771, Bioorganic & Medicinal Chemistry Letters, 2012, Mohamed, Tarek et. al.
Development and evaluation of multifunctional agents for potential treatment of Alzheimer’s disease: Application to a pyrimidine-2,4-diamine template
score: 1.4916771, Bioorganic & Medicinal Chemistry Letters, 2012, Mohamed, Tarek et. al.
Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A
score: 1.4915672, Bioorganic & Medicinal Chemistry Letters, 2006, Torikai, Kohei et. al.
Bioengineering functional copolymers. XIV. Synthesis and interaction of poly( N-isopropylacrylamide- co-3,4-dihydro-2 H-pyran- alt-maleic anhydride)s with SCLC cancer cells
score: 1.4913756, Bioorganic & Medicinal Chemistry, 2010, Türk, Mustafa; Rzayev, Zakir M.O.; Khalilova, Sevda A.
Chiral, nonracemic (piperazin-2-yl)methanol derivatives with σ-receptor affinity
score: 1.4912623, Bioorganic & Medicinal Chemistry, 2004, Bedürftig, Stephan; Wünsch, Bernhard
Synthesis and Structure–Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl)glycines as High-Affinity Group II Metabotropic Glutamate Receptor Ligands
score: 1.4911805, Bioorganic & Medicinal Chemistry, 2003, Sørensen, Ulrik S et. al.
Chemoselective synthesis of erythromycin A ketolides substituted in the C10-methyl group
score: 1.4911535, Bioorganic & Medicinal Chemistry, 2007, Gunnes, Sølvi; Undheim, Kjell
N-DEVD-N′-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay
score: 1.4911392, Bioorganic & Medicinal Chemistry Letters, 2005, Wang, Zhi-Qiang; Liao, Jinfang; Diwu, Zhenjun
Anticancer and superoxide scavenging activities of p-alkylaminophenols having various length alkyl chains
score: 1.4910665, Bioorganic & Medicinal Chemistry, 2006, Takahashi, Noriko; Honda, Toshio; Ohba, Toshihiro
Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides
score: 1.4910185, European Journal of Medicinal Chemistry, 2012, Pradère, Ugo et. al.
Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides
score: 1.4910185, European Journal of Medicinal Chemistry, 2012, Pradère, Ugo et. al.
Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides
score: 1.4910185, European Journal of Medicinal Chemistry, 2012, Pradère, Ugo et. al.
Synthesis and biological evaluation of new 4 H-pyrano[2,3- b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals
score: 1.4909867, European Journal of Medicinal Chemistry, 2006, Marco-Contelles, José et. al.
Development of novel linkers to conjugate pharmacophores to a carrier antibody
score: 1.4908613, Bioorganic & Medicinal Chemistry Letters, 2012, Palanki, Moorthy S.S. et. al.
Development of novel linkers to conjugate pharmacophores to a carrier antibody
score: 1.4908613, Bioorganic & Medicinal Chemistry Letters, 2012, Palanki, Moorthy S.S. et. al.
Development of novel linkers to conjugate pharmacophores to a carrier antibody
score: 1.4908613, Bioorganic & Medicinal Chemistry Letters, 2012, Palanki, Moorthy S.S. et. al.
Aminoglycosides: activity and resistance.
score: 1.4907618, Antimicrobial agents and chemotherapy, 1999, Mingeot-Leclercq, M P; Glupczynski, Y; Tulkens, P M
Activities and conformational fitting of 1,4-naphthoquinone derivatives and other cyclic 1,4-diones tested in vitro against Pneumocystis carinii.
score: 1.4907525, Antimicrobial agents and chemotherapy, 2001, Ball, M D et. al.
The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5- a]-pyrimidine: A corticotropin-releasing factor (hCRF 1) antagonist
score: 1.4906686, Bioorganic & Medicinal Chemistry, 2000, Gilligan, Paul J. et. al.
Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors
score: 1.4906331, Bioorganic & Medicinal Chemistry, 2012, Qiu, Ke-Ming et. al.
Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors
score: 1.4906331, Bioorganic & Medicinal Chemistry, 2012, Qiu, Ke-Ming et. al.
Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis.
score: 1.4906008, Antimicrobial agents and chemotherapy, 2012, Grau, Thomas et. al.
3D-Chiral quadratic indices of the ‘molecular pseudograph’s atom adjacency matrix’ and their application to central chirality codification: classification of ACE inhibitors and prediction of σ-receptor antagonist activities
score: 1.4905412, Bioorganic & Medicinal Chemistry, 2004, Marrero Ponce, Yovani et. al.
Synthesis and anti-tuberculosis activity of new hetero(Mn, Co, Ni)trinuclear iron(III) furoates
score: 1.490415, European Journal of Medicinal Chemistry, 2010, Melnic, Silvia et. al.
New potential inhibitors of cyclin-dependent kinase 4: Design and synthesis of pyrido[2,3- d]pyrimidine derivatives under microwave irradiation
score: 1.4903887, Bioorganic & Medicinal Chemistry Letters, 2006, Tu, Shujiang et. al.
Stereoselective synthesis of novel cyclopropyl analogues of known cysteine protease inhibitors
score: 1.4903841, Bioorganic & Medicinal Chemistry Letters, 1999, Ravi Kumar, Jalluri S.; Roy, Subho; Datta, Apurba
Catalyst-free tandem aldol condensation/Michael addition of 1,3-cyclohexanediones with enolizable aldehydes
score: 1.490259, Bioorganic & Medicinal Chemistry Letters, 2009, Rohr, Kerstin; Mahrwald, Rainer
Analysis of antimalarial synergy between bestatin and endoprotease inhibitors using statistical response-surface modelling.
score: 1.4900736, Antimicrobial agents and chemotherapy, 2001, Gavigan, C S; Machado, S G; Dalton, J P; Bell, A
Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives
score: 1.4899819, Bioorganic & Medicinal Chemistry, 2006, Amr, Abdel-Galil E. et. al.
Novel α-aminophosphonic acids. Design, characterization, and biological activity
score: 1.4898716, Bioorganic & Medicinal Chemistry, 2006, Naydenova, Emilia et. al.
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential
score: 1.4897796, Bioorganic & Medicinal Chemistry Letters, 2012, Sams, Anette Graven et. al.
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential
score: 1.4897796, Bioorganic & Medicinal Chemistry Letters, 2012, Sams, Anette Graven et. al.
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential
score: 1.4897796, Bioorganic & Medicinal Chemistry Letters, 2012, Sams, Anette Graven et. al.
Corifungin, a New Drug Lead against Naegleria, Identified from a High-Throughput Screen.
score: 1.4895763, Antimicrobial agents and chemotherapy, 2012, Debnath, Anjan et. al.
Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens.
score: 1.4895412, Antimicrobial agents and chemotherapy, 2011, Jabés, Daniela et. al.
New ionic derivatives of betulinic acid as highly potent anti-cancer agents
score: 1.4894183, Bioorganic & Medicinal Chemistry Letters, 2012, Suresh, Challa et. al.
Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum
score: 1.4893774, Bioorganic & Medicinal Chemistry, 1997, Beutler, John A. et. al.
Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum
score: 1.4893774, Bioorganic & Medicinal Chemistry, 1997, Beutler, John A. et. al.
Effect of adenosine modified with a boron cluster pharmacophore on reactive oxygen species production by human neutrophils
score: 1.4892921, Bioorganic & Medicinal Chemistry, 2012, Bednarska, Katarzyna et. al.
Effect of adenosine modified with a boron cluster pharmacophore on reactive oxygen species production by human neutrophils
score: 1.4892921, Bioorganic & Medicinal Chemistry, 2012, Bednarska, Katarzyna et. al.
In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates
score: 1.4892679, Bioorganic & Medicinal Chemistry, 2012, Dang, Hung The et. al.
In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates
score: 1.4892679, Bioorganic & Medicinal Chemistry, 2012, Dang, Hung The et. al.
Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1
score: 1.4892382, Bioorganic & Medicinal Chemistry Letters, 2012, De Luca, Viviana et. al.
Protease inhibitors. Part 8: synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated l-alanine hydroxamate moieties
score: 1.4891729, Bioorganic & Medicinal Chemistry, 2000, Scozzafava, Andrea; Supuran, Claudiu T.
Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1
score: 1.4891518, Bioorganic & Medicinal Chemistry, 2002, Kumar, Devinder et. al.
Solid-phase synthesis of acridine-based threading intercalator peptides
score: 1.4890263, Bioorganic & Medicinal Chemistry Letters, 2000, Carlson, Coby B; Beal, Peter A
Studies on n-Octyl-5-(α- d-arabinofuranosyl)-β- d-galactofuranosides for Mycobacterial Glycosyltransferase Activity
score: 1.4888899, Bioorganic & Medicinal Chemistry, 2002, Pathak, Ashish K et. al.
Synthesis and biological evaluation of new derivatives of emodin
score: 1.4887401, Bioorganic & Medicinal Chemistry, 2004, Teich, Lars et. al.
Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c
score: 1.4884753, Bioorganic & Medicinal Chemistry Letters, 2012, Yamaguchi, Yoshinobu et. al.
Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library
score: 1.4883338, Bioorganic & Medicinal Chemistry, 2003, Thutewohl, Michael et. al.
Copper-mediated DNA photocleavage by a tetrapyridoacridine (tpac) ligand
score: 1.4883249, Bioorganic & Medicinal Chemistry Letters, 2008, Marta González-Álvarez, et. al.
5′-[2-(2-Nitrophenyl)-2-methylpropionyl]-2′-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: synthesis, stability and reductive activation
score: 1.4882934, Bioorganic & Medicinal Chemistry Letters, 2000, Hu, Longqin; Liu, Bin; Hacking, Douglas R
Design and synthesis of thiol-reactive lipopeptides
score: 1.4882723, Bioorganic & Medicinal Chemistry Letters, 1998, Boeckler, Christophe; Frisch, Benoît; Schuber, Francis
Synthetic studies on himbacine, a potent antagonist of the muscarinic M 2 subtype receptor. Part 2: Synthesis and muscarinic M 2 subtype antagonistic activity of the novel himbacine congeners modified at the C-3 position of lactone moiety
score: 1.488219, Bioorganic & Medicinal Chemistry, 2003, Takadoi, Masanori; Yamaguchi, Kentaro; Terashima, Shiro
Sesterterpenoids and an alkaloid from a Thorectandra sp. as inhibitors of the phosphatase Cdc25B
score: 1.488202, Bioorganic & Medicinal Chemistry, 2005, Cao, Shugeng et. al.
Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors
score: 1.4880543, Bioorganic & Medicinal Chemistry Letters, 2012, Xiang, Yang-Fei et. al.
Novel antiallergic and antiinflammatory agents. Part II: Synthesis and pharmacology of TYB-2285 and its related compounds
score: 1.4880453, Bioorganic & Medicinal Chemistry, 1998, Ban, Masakazu et. al.
Synthesis of nucleoside phosphosulfates
score: 1.4878738, Bioorganic & Medicinal Chemistry Letters, 2012, Kowalska, Joanna et. al.
Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity
score: 1.4878212, Bioorganic & Medicinal Chemistry, 2006, Matsuda, Hisashi et. al.
Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists
score: 1.4877769, Bioorganic & Medicinal Chemistry Letters, 2012, Xiao, Dong et. al.
Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists
score: 1.4877769, Bioorganic & Medicinal Chemistry Letters, 2012, Xiao, Dong et. al.
Discovery and structural development of small molecules that enhancetransportactivityof bile salt export pump mutant associated withprogressive familial intrahepatic cholestasis type 2
score: 1.4876894, Bioorganic & Medicinal Chemistry, 2012, Misawa, Takashi et. al.
2-Azetidinone cholesterol absorption inhibitors: increased potency by substitution of the C-4 phenyl ring
score: 1.4875173, Bioorganic & Medicinal Chemistry, 1998, Vaccaro, Wayne D.; Sher, Rosy; Davis, Harry R.
Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds
score: 1.4875003, European Journal of Medicinal Chemistry, 2006, Gilleron, P. et. al.
Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.
score: 1.4874731, Antimicrobial agents and chemotherapy, 2002, Gerum, A'Lissa B et. al.
An efficient approach to N-acetyl- d-glucosaminuronic acid-based sialylmimetics as potential sialidase inhibitors
score: 1.4874706, Bioorganic & Medicinal Chemistry Letters, 2004, Mann, Maretta C.; Thomson, Robin J.; von Itzstein, Mark
Synthesis of 13C-Labeled iodoacetanilide and application to quantitative peptide analysis by isotope differential mass spectrometry
score: 1.4874292, Bioorganic & Medicinal Chemistry Letters, 2003, Niwayama, Satomi; Kurono, Sadamu; Matsumoto, Hiroyuki
HL 752: A potent and long-acting antispasmodic agent
score: 1.4874245, Bioorganic & Medicinal Chemistry, 1997, Bal-Tembe, Swati et. al.
Prediction of binding affinities to β 1 isoform of human thyroid hormone receptor by genetic algorithm and projection pursuit regression
score: 1.4873548, Bioorganic & Medicinal Chemistry Letters, 2007, Ren, Yueying et. al.
Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease
score: 1.4873145, European Journal of Medicinal Chemistry, 2012, Pawar, Sachin A. et. al.
Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease
score: 1.4873145, European Journal of Medicinal Chemistry, 2012, Pawar, Sachin A. et. al.
Prostaglandin E 2-bisphosphonate conjugates: potential agents for treatment of osteoporosis
score: 1.4872604, Bioorganic & Medicinal Chemistry, 1999, Gil, Laurent et. al.
Two non-racemic preparations of a piperidine-based NMDA antagonist with analgesic activity
score: 1.4871828, Bioorganic & Medicinal Chemistry, 1997, Swahn, Britt-Marie et. al.
Halohydrin and Oxime Derivatives of Radicicol: Synthesis and Antitumor Activities
score: 1.4871604, Bioorganic & Medicinal Chemistry, 2002, Agatsuma, Tsutomu et. al.
Synthesis and evaluation of amino acid esters of 6-deoxypenciclovir as potential prodrugs of penciclovir
score: 1.4871528, Bioorganic & Medicinal Chemistry, 1999, Kim, Dae-Kee et. al.
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels−Alder reaction
score: 1.4863691, Bioorganic & Medicinal Chemistry, 2012, Ji, Cheng et. al.
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses
score: 1.4862637, Bioorganic & Medicinal Chemistry Letters, 2012, Dao, Trong Tuan et. al.
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses
score: 1.4862637, Bioorganic & Medicinal Chemistry Letters, 2012, Dao, Trong Tuan et. al.
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses
score: 1.4862637, Bioorganic & Medicinal Chemistry Letters, 2012, Dao, Trong Tuan et. al.
Development of 3D-QSAR models for 5-Lipoxygenase antagonists: chalcones
score: 1.4861939, Bioorganic & Medicinal Chemistry, 2002, Arockia Babu, M et. al.
Chemoenzymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with a γ-polyglutamic acid backbone and their effect on inhibition of infection by influenza viruses
score: 1.485979, Bioorganic & Medicinal Chemistry, 2007, Ogata, Makoto et. al.
New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation
score: 1.4858615, Bioorganic & Medicinal Chemistry Letters, 2004, Tu, Shujiang et. al.
Oxidative and reductive transformations of epothilone A
score: 1.4857497, Bioorganic & Medicinal Chemistry Letters, 1998, Sefkow, Michael et. al.
Synthesis and characterization of water-soluble free-base, zinc and copper porphyrin–oligonucleotide conjugates
score: 1.4857497, Bioorganic & Medicinal Chemistry, 2008, Mammana, Angela et. al.
Estrogenic activity of B-fluorinated o-carborane-1,2-bisphenol synthesized via SNAr reaction
score: 1.4857128, Bioorganic & Medicinal Chemistry Letters, 2012, Ohta, Kiminori; Ogawa, Takumi; Endo, Yasuyuki
New amino and acetamido monomethine cyanine dyes for the detection of DNA in agarose gels
score: 1.4856985, Bioorganic & Medicinal Chemistry, 2007, El-Shishtawy, Reda M. et. al.
A new and efficient synthesis of substituted 6-[(2′-Dialkylamino)ethyl] pyrimidine and 4- N,N-Dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-Rubella activity
score: 1.4856888, Bioorganic & Medicinal Chemistry, 2002, Saladino, Raffaele et. al.
Structure–activity relationship study on small peptidic GPR54 agonists
score: 1.4856418, Bioorganic & Medicinal Chemistry, 2006, Tomita, Kenji et. al.
Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound
score: 1.4855054, Bioorganic & Medicinal Chemistry, 2012, Sakamoto, Satoshi et. al.
New 3-piperonylcoumarins as inhibitors of glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) from Trypanosoma cruzi
score: 1.4854192, Bioorganic & Medicinal Chemistry, 2004, de Marchi, Anderson Aparecido et. al.
Design, synthesis and preliminary biological evaluations of novel amphiphilic drug carriers
score: 1.4853924, Bioorganic & Medicinal Chemistry Letters, 2006, Périno, Sandrine et. al.
Bicyclic peptidomimetic tetrahydrofuro[3,2- b]pyrrol-3-one and hexahydrofuro[3,2- b]pyridine-3-one based scaffolds: synthesis and cysteinyl proteinase inhibition
score: 1.4853306, Bioorganic & Medicinal Chemistry, 2004, Quibell, Martin et. al.
Cosubstrate Tolerance of the Aminoglycoside Resistance Enzyme Eis from Mycobacterium tuberculosis.
score: 1.4853167, Antimicrobial agents and chemotherapy, 2012, Chen, Wenjing; Green, Keith D; Garneau-Tsodikova, Sylvie
5-Substituted-2,3-diphenyltetrahydrofurans: A new class of moderately selective COX-2 inhibitors
score: 1.4852474, Bioorganic & Medicinal Chemistry, 2006, Singh, Palwinder et. al.
Eicosapentaenoic-acid-derived isoprostanes: Synthesis and discovery of two major isoprostanes
score: 1.484906, Bioorganic & Medicinal Chemistry Letters, 2008, Chang, Chih-Tsung et. al.
In silico binding free energy predictability with π–π interaction energy-augmented scoring function: Benzimidazole Raf inhibitors as a case study
score: 1.4848438, Bioorganic & Medicinal Chemistry Letters, 2012, Chung, Jae Yoon; Cho, Seung Joo; Cho, Art E.; Hah, Jung-Mi
In silico binding free energy predictability with π–π interaction energy-augmented scoring function: Benzimidazole Raf inhibitors as a case study
score: 1.4848438, Bioorganic & Medicinal Chemistry Letters, 2012, Chung, Jae Yoon; Cho, Seung Joo; Cho, Art E.; Hah, Jung-Mi
In silico binding free energy predictability with π–π interaction energy-augmented scoring function: Benzimidazole Raf inhibitors as a case study
score: 1.4848438, Bioorganic & Medicinal Chemistry Letters, 2012, Chung, Jae Yoon; Cho, Seung Joo; Cho, Art E.; Hah, Jung-Mi
Synthesis and structure-activity relationships of dual histamine H 2 and gastrin receptor antagonists with noncyclic gastrin receptor antagonistic moieties
score: 1.4848395, Bioorganic & Medicinal Chemistry, 1997, Kawanishi, Yasuyuki et. al.
Organic synthesis in pursuit of immunology: Large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine
score: 1.484792, Bioorganic & Medicinal Chemistry, 2005, Cho, Young Shin; Wan, Qian; Danishefsky, Samuel J.
Antitrypanosomal activities of proteasome inhibitors.
score: 1.4847371, Antimicrobial agents and chemotherapy, 2002, Nkemngu, Njinkeng Joseph et. al.
Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3
score: 1.484642, Bioorganic & Medicinal Chemistry Letters, 2013, Ye, Long et. al.
Synthesis, characterization and reactions of 2-deoxo-5-deazaalloxazines
score: 1.4845374, Bioorganic & Medicinal Chemistry, 2001, Sarhan, Abd El-Wareth A.O. et. al.
A highly sensitive fluorescent viscosity sensor
score: 1.4843121, Bioorganic & Medicinal Chemistry Letters, 2012, Yusop, Rahimi M.; Unciti-Broceta, Asier; Bradley, Mark
Small kinase assay panels can provide a measure of selectivity
score: 1.484223, Bioorganic & Medicinal Chemistry Letters, 2009, Brandt, Peter; Jensen, Annika Jenmalm; Nilsson, Jonas
Synthesis and antinociceptive activity of chimonanthines and pyrrolidinoindoline-Type alkaloids
score: 1.484176, Bioorganic & Medicinal Chemistry, 2002, Verotta, L et. al.
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment
score: 1.484114, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Dong-Hwan et. al.
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment
score: 1.484114, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Dong-Hwan et. al.
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment
score: 1.484114, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Dong-Hwan et. al.
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties
score: 1.4840548, European Journal of Medicinal Chemistry, 2005, Dias, Nathalie et. al.
Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species
score: 1.4840205, European Journal of Medicinal Chemistry, 2012, Vianna, D.R. et. al.
Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species
score: 1.4840205, European Journal of Medicinal Chemistry, 2012, Vianna, D.R. et. al.
Design and synthesis of Rhodamine 110 derivative and Caspase-3 substrate for enzyme and cell-based fluorescent assay
score: 1.48394, Bioorganic & Medicinal Chemistry Letters, 2001, Cai, Sui Xiong et. al.
Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: Enhanced enzymatic stability and biological properties
score: 1.4839127, European Journal of Medicinal Chemistry, 2012, Laimou, Despina et. al.
Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II–trithiocarbonate adduct—An inhibitor mimicking the sulfonamide and urea binding to the enzyme
score: 1.4838916, Bioorganic & Medicinal Chemistry Letters, 2010, Temperini, Claudia; Scozzafava, Andrea; Supuran, Claudiu T.
A new 9,11-secosterol from the soft coral Sinularia granosa
score: 1.4837318, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Chiung-Yao et. al.
A new 9,11-secosterol from the soft corals Sinularia granosa
score: 1.4837318, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Chiung-Yao et. al.
A new 9,11-secosterol from the soft coral Sinularia granosa
score: 1.4837318, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Chiung-Yao et. al.
Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria
score: 1.483716, European Journal of Medicinal Chemistry, 2013, Li, Xin; Ma, Siti; Yan, Mi; Wang, Yuanze; Ma, Shutao
Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria
score: 1.483716, European Journal of Medicinal Chemistry, 2013, Li, Xin; Ma, Siti; Yan, Mi; Wang, Yuanze; Ma, Shutao
Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly.
score: 1.4836574, Antimicrobial agents and chemotherapy, 2001, Bonnet, R et. al.
Optimizing phenylethylphosphonamidates for the inhibition of prostate-specific membrane antigen
score: 1.4835415, Bioorganic & Medicinal Chemistry, 2006, Wone, David W.G. et. al.
Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V
score: 1.4833846, European Journal of Medicinal Chemistry, 2012, Marques, Emerson F. et. al.
Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles
score: 1.4833722, Bioorganic & Medicinal Chemistry, 1997, Hori, Hitoshi et. al.
Norbornyllactone-substituted xanthines as adenosine A 1 receptor antagonists
score: 1.4833156, Bioorganic & Medicinal Chemistry, 2006, Kiesman, William F. et. al.
Non-isosteric C-glycosyl analogues of natural nucleotide diphosphate sugars as glycosyltransferase inhibitors
score: 1.4832748, Bioorganic & Medicinal Chemistry, 2006, Vidal, Sébastien et. al.
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1’-biphenyl]-4-ylethyl) analogues of 8-CAC
score: 1.4832218, Bioorganic & Medicinal Chemistry Letters, 2012, Wentland, Mark P. et. al.
Design, synthesis and binding properties of novel and selective 5-HT 3 and 5-HT 4 receptor ligands
score: 1.4830566, European Journal of Medicinal Chemistry, 2001, Modica, Maria et. al.
Nonsteroidal progesterone receptor ligands (II); synthesis and SAR of new tetrahydrobenzindolone derivatives
score: 1.4830097, Bioorganic & Medicinal Chemistry, 2006, Kurihara, Ken-ichi et. al.
Simple one-pot synthesis of a 2′-tritium labeled C-deoxynucleoside
score: 1.4830051, Bioorganic & Medicinal Chemistry Letters, 1999, Lutz, Stefan; Benner, Steven A.
Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists
score: 1.482945, Bioorganic & Medicinal Chemistry Letters, 2012, Zulli, Allison L. et. al.
EASY-HIT: HIV full-replication technology for broad discovery of multiple classes of HIV inhibitors.
score: 1.4828908, Antimicrobial agents and chemotherapy, 2010, Kremb, Stephan et. al.
Steric interactions and the activity of fentanyl analogs at the μ-opioid receptor
score: 1.4828407, Bioorganic & Medicinal Chemistry, 2006, Dosen-Micovic, Ljiljana; Ivanovic, Milovan; Micovic, Vuk
Synthesis of (1 S,2 R)-1-Phenyl-2-[( S)-1-aminopropyl] -N,N-diethylcyclopropanecarboxamide (PPDC) Derivatives Modified at the Carbamoyl Moiety As a New Class of NMDA Receptor Antagonists
score: 1.482739, Bioorganic & Medicinal Chemistry, 2002, Kazuta, Yuji et. al.
Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives
score: 1.4826181, European Journal of Medicinal Chemistry, 2006, Nagaoka, Y. et. al.
Molecular structure and dynamics of some potent 5-HT 3 receptor antagonists. Insight into the interaction with the receptor
score: 1.4825631, Bioorganic & Medicinal Chemistry, 1996, Cappelli, Andrea et. al.
The existence of a second allosteric site on the M 1 muscarinic acetylcholine receptor and its implications for drug design
score: 1.4824212, Bioorganic & Medicinal Chemistry Letters, 2006, Espinoza-Fonseca, L. Michel; Trujillo-Ferrara, José G.
Synthesis and immunological activity of water-soluble Thalidomide prodrugs
score: 1.4824072, Bioorganic & Medicinal Chemistry, 2001, Hess, Sonja et. al.
Binding of an aminoacridine derivative to a GAAA RNA tetraloop
score: 1.4823188, Bioorganic & Medicinal Chemistry Letters, 2004, Yan, Zhaohui; Baranger, Anne M.
Synthesis and antibiofilm activity of marine natural product-based 4-thiazolidinones derivatives
score: 1.4822858, Bioorganic & Medicinal Chemistry Letters, 2012, Rane, Rajesh A.; Sahu, Niteshkumar U.; Shah, Chetan P.
Chemo-enzymatic synthesis of 1,4-oxazepanyl sugar as potent inhibitor of chitinase
score: 1.4820678, Bioorganic & Medicinal Chemistry, 2006, Huang, Gang-Liang et. al.
Novel oxa-spermine homologues: synthesis and cytotoxic properties
score: 1.482009, Bioorganic & Medicinal Chemistry, 2002, Kuksa, Vladimir A.; Pavlov, Valentin A.; Thoo Lin, Paul Kong
On the topological evidences for modelling lipophilicity
score: 1.4819987, Bioorganic & Medicinal Chemistry, 2002, Agrawal, Vijay K.; Singh, Jyoti; Khadikar, Padmakar V.
Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N 3) 2(isn) 2]
score: 1.4819682, European Journal of Medicinal Chemistry, 2010, de Souza, Rodrigo A. et. al.
Preparation and biochemical evaluation of fluorenone-containing lipid analogs
score: 1.4818857, Bioorganic & Medicinal Chemistry Letters, 2006, Spencer, Thomas A. et. al.
5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides
score: 1.4818338, Bioorganic & Medicinal Chemistry Letters, 2007, Deglane, Gaëlle et. al.
Bio-inspired synthesis and biological evaluation of a colchicine-related compound library
score: 1.4817401, Bioorganic & Medicinal Chemistry Letters, 2012, Nicolaou, K.C. et. al.
Bio-inspired synthesis and biological evaluation of a colchicine-related compound library
score: 1.4817401, Bioorganic & Medicinal Chemistry Letters, 2012, Nicolaou, K.C. et. al.
Bio-inspired synthesis and biological evaluation of a colchicine-related compound library
score: 1.4817401, Bioorganic & Medicinal Chemistry Letters, 2012, Nicolaou, K.C. et. al.
DNA binding acridine–thiazolidinone agents affecting intracellular glutathione
score: 1.4816935, Bioorganic & Medicinal Chemistry, 2012, Paulíková, Helena et. al.
DNA binding acridine–thiazolidinone agents affecting intracellular glutathione
score: 1.4816935, Bioorganic & Medicinal Chemistry, 2012, Paulíková, Helena et. al.
Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I.
score: 1.4816833, Antimicrobial agents and chemotherapy, 2012, Therien, Alex G et. al.
Utilization of [11C]phosgene for radiosynthesis of N-(2-{3-[3,5-bis(trifluoromethyl)]phenyl[11C]ureido}ethyl)glycyrrhetinamide, an inhibitory agent for proteasome and kinase in tumors
score: 1.4816392, Bioorganic & Medicinal Chemistry Letters, 2012, Asakawa, Chiharu et. al.
Utilization of [11C]phosgene for radiosynthesis of N-(2-{3-[3,5-bis(trifluoromethyl)]phenyl[11C]ureido}ethyl)glycyrrhetinamide, an inhibitory agent for proteasome and kinase in tumors
score: 1.4816392, Bioorganic & Medicinal Chemistry Letters, 2012, Asakawa, Chiharu et. al.
Utilization of [11C]phosgene for radiosynthesis of N-(2-{3-[3,5-bis(trifluoromethyl)]phenyl[11C]ureido}ethyl)glycyrrhetinamide, an inhibitory agent for proteasome and kinase in tumors
score: 1.4816392, Bioorganic & Medicinal Chemistry Letters, 2012, Asakawa, Chiharu et. al.
Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase.
score: 1.4815906, Antimicrobial agents and chemotherapy, 2000, Alovero, F L; Pan, X S; Morris, J E; Manzo, R H; Fisher, L M
Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT2C agonists
score: 1.4815226, Bioorganic & Medicinal Chemistry Letters, 2012, Conway, Richard J. et. al.
Identification of novel 3,5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents
score: 1.4814525, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Qing-Shan et. al.
Identification of novel 3,5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents
score: 1.4814525, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Qing-Shan et. al.
Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives
score: 1.4814222, Bioorganic & Medicinal Chemistry Letters, 2007, Ye, Qing-Song et. al.
An alternative synthesis of 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, an intermediate in sterol biosynthesis and a reported activator of meiosis and of nuclear orphan receptor LXRα
score: 1.481388, Bioorganic & Medicinal Chemistry Letters, 1998, Ruan, B; Wilson, W.K; Schroepfer, G.J
Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability
score: 1.4813461, Bioorganic & Medicinal Chemistry, 2012, Scherman, Michael S. et. al.
Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability
score: 1.4813461, Bioorganic & Medicinal Chemistry, 2012, Scherman, Michael S. et. al.
Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability
score: 1.4813461, Bioorganic & Medicinal Chemistry, 2012, Scherman, Michael S. et. al.
A practical and green approach towards synthesis of dihydropyrimidinones: Using heteropoly acids as efficient catalysts
score: 1.4813096, Bioorganic & Medicinal Chemistry Letters, 2006, Rafiee, Ezzat; Jafari, Hadi
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits
score: 1.4813093, Bioorganic & Medicinal Chemistry, 2012, Cho, Jung Keun et. al.
Synthesis and biological evaluation of a novel 99mTc cyclopentadienyl tricarbonyl complex ([(Cp-R)99mTc(CO)3]) for sigma-2 receptor tumor imaging
score: 1.4810743, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Xin et. al.
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase
score: 1.4810606, Bioorganic & Medicinal Chemistry Letters, 2013, Powell, Noel A. et. al.
Synthesis and structural modeling of the amphiphilic siderophore rhizobactin-1021 and its analogs
score: 1.4810294, Bioorganic & Medicinal Chemistry Letters, 2005, Fadeev, Evgeny A.; Luo, Minkui; Groves, John T.
QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1
score: 1.4809077, Bioorganic & Medicinal Chemistry, 2006, Frecer, Vladimir
Substrate spectrum extension of PenA in Burkholderia thailandensis with a single amino acid deletion, Glu168del.
score: 1.4808357, Antimicrobial agents and chemotherapy, 2012, Yi, Hyojeong et. al.
Structural basis of the dynamic mechanism of ligand binding to cyclooxygenase
score: 1.4807014, Bioorganic & Medicinal Chemistry Letters, 1999, Llorens, Oriol et. al.
Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications
score: 1.4806015, Bioorganic & Medicinal Chemistry Letters, 2006, Kim, Moon Suk; Diamond, Scott L.
Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola
score: 1.4801558, Bioorganic & Medicinal Chemistry Letters, 2009, Minami, Atsushi et. al.
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
score: 1.480059, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
score: 1.480059, European Journal of Medicinal Chemistry, 2012, Samadi, Abdelouahid et. al.
A radial distribution function approach to predict A 2B agonist effect of adenosine analogues
score: 1.4799371, Bioorganic & Medicinal Chemistry, 2005, González, Maykel Pérez et. al.
Design, synthesis and binding at cloned muscarinic receptors of N-[5-(1′-substituted-acetoxymethyl)-3-oxadiazolyl] and N-[4-(1′-substituted-acetoxymethyl)-2-dioxolanyl] dialkyl amines
score: 1.4798846, Bioorganic & Medicinal Chemistry, 2000, Manfredini, Stefano et. al.
Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.
score: 1.4797012, Antimicrobial agents and chemotherapy, 2006, Widmer, Fred et. al.
β-Carboline–Carbohydrate hybrids: molecular design, chemical synthesis and evaluation of novel DNA photocleavers
score: 1.4795975, Bioorganic & Medicinal Chemistry Letters, 2002, Toshima, Kazunobu et. al.
Selection, optimization, and pharmacokinetic properties of a novel, potent antiviral locked nucleic acid-based antisense oligomer targeting hepatitis C virus internal ribosome entry site.
score: 1.4794395, Antimicrobial agents and chemotherapy, 2011, Laxton, Carl et. al.
A molecular docking study of estrogenically active compounds with 1,2-diarylethane and 1,2-diarylethene pharmacophores
score: 1.4792319, Bioorganic & Medicinal Chemistry, 2004, Kekenes-Huskey, Peter M. et. al.
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs
score: 1.4791518, Bioorganic & Medicinal Chemistry, 2008, Hanessian, Stephen et. al.
Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania
score: 1.47908, Bioorganic & Medicinal Chemistry Letters, 2012, Caballero, Esther et. al.
New N 6- or N(9)-hydroxyalkyl substituted 8-azaadenines or adenines as effective A 1 adenosine receptor ligands
score: 1.4790344, European Journal of Medicinal Chemistry, 2003, Biagi, Giuliana et. al.
Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane
score: 1.4790199, Bioorganic & Medicinal Chemistry Letters, 2006, Yu, Chun-Wing et. al.
In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class.
score: 1.4789769, Antimicrobial agents and chemotherapy, 2006, Mani, Nagraj et. al.
Classification of dopamine, serotonin, and dual antagonists by decision trees
score: 1.4789011, Bioorganic & Medicinal Chemistry, 2006, Kim, Hye-Jung et. al.
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.
score: 1.4788626, Antimicrobial agents and chemotherapy, 2012, Jakobsen, Tim Holm et. al.
Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A
score: 1.4787115, Bioorganic & Medicinal Chemistry, 2004, Park, Jung Dae; Kim, Dong H.
In vitro aldose reductase inhibitory activity of 5-benzyl-2,4-thiazolidinediones
score: 1.4787095, Bioorganic & Medicinal Chemistry, 2006, Rakowitz, Dietmar et. al.
Palladium(II) complexes with R 2edda derived ligands. Part IV. O,O′-dialkyl esters of ( S,S)-ethylenediamine- N,N′-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral activity against chronic lymphocytic leukemia (CLL) cells
score: 1.4786706, European Journal of Medicinal Chemistry, 2010, Vujić, Jelena M. et. al.
Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging
score: 1.4785331, Bioorganic & Medicinal Chemistry Letters, 2007, Dhimitruka, Ilirian et. al.
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: Possible confounding effects on in vivo and in vitro studies
score: 1.4782838, Bioorganic & Medicinal Chemistry Letters, 2012, McElhinny, Charles J. et. al.
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: Possible confounding effects on in vivo and in vitro studies
score: 1.4782838, Bioorganic & Medicinal Chemistry Letters, 2012, McElhinny, Charles J. et. al.
Synthesis of S 6-(2,4-dinitrophenyl)-6-thioguanosine phosphoramidite and its incorporation into oligoribonucleotides
score: 1.4782344, Bioorganic & Medicinal Chemistry Letters, 2003, Zheng, Qinguo; Wang, Yang; Lattmann, Eric
The conjugates of uracil–cyclen Zn(II) complexes: Synthesis, characterization, and their interaction with plasmid DNA
score: 1.4782332, Bioorganic & Medicinal Chemistry, 2006, Xia, Chuan-Qin et. al.
Antitumor agents 251: Synthesis, cytotoxic evaluation, and structure–activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents
score: 1.4782027, Bioorganic & Medicinal Chemistry, 2006, Wei, Linyi et. al.
S1 subsite in snake venom thrombin-like enzymes: can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors?
score: 1.4781875, Bioorganic & Medicinal Chemistry, 2004, Silva, Floriano P.; De-Simone, Salvatore G.
Facile synthesis of a dimeric dipyrrole–polyamide and synergetic DNA-cleaving activity of its Cu(II) complex
score: 1.478099, Bioorganic & Medicinal Chemistry Letters, 2012, Zhou, Chun-Qiong et. al.
Coupling of Isoprenoid Triflates with Organoboron Nucleophiles: Synthesis and Biological Evaluation of Geranylgeranyl Diphosphate Analogues
score: 1.4778603, Bioorganic & Medicinal Chemistry, 2002, Mu, YongQi et. al.
Antitumor agents 210. synthesis and evaluation of taxoid–epipodophyllotoxin conjugates as novel cytotoxic agents
score: 1.4777589, Bioorganic & Medicinal Chemistry, 2001, Shi, Qian et. al.
New substrates and inhibitors of γ-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: Design, synthesis, and biological activity
score: 1.4773543, Bioorganic & Medicinal Chemistry, 2006, Yuan, Hai; Silverman, Richard B.
Expedient synthesis of a series of N-acetyllactosamines
score: 1.4771434, Bioorganic & Medicinal Chemistry Letters, 1999, M , J.C.; Fukuda, M.; Hindsgaul, O.
Synthesis of a N-acylsulfamide linked dinucleoside and its incorporation into an oligonucleotide
score: 1.476945, Bioorganic & Medicinal Chemistry Letters, 1999, Zhang, Jiancun; Matteucci, Mark D.
Self-organizing molecular field analysis of NSAIDs: Assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach
score: 1.476918, European Journal of Medicinal Chemistry, 2012, Honey, ; Thareja, Suresh; Kumar, Manoj; Sinha, V.R.
Self-organizing molecular field analysis of NSAIDs: Assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach
score: 1.476918, European Journal of Medicinal Chemistry, 2012, Honey, ; Thareja, Suresh; Kumar, Manoj; Sinha, V.R.
Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives
score: 1.4768887, European Journal of Medicinal Chemistry, 2012, He, Xianran et. al.
Conformational analysis of rhazinilam and three-dimensional quantitative structure–activity relationships of rhazinilam analogues
score: 1.4767682, Bioorganic & Medicinal Chemistry Letters, 2005, Morita, Hiroshi et. al.
Targeting the DNA minor groove with fused ring dicationic compounds: Comparison of in silico screening and a high-resolution crystal structure
score: 1.4767205, Bioorganic & Medicinal Chemistry Letters, 2006, Campbell, Nancy H. et. al.
Odorless benzenethiols in synthesis of thioglycosides and its application for glycosylation reactions
score: 1.4765931, Bioorganic & Medicinal Chemistry Letters, 2006, Kajimoto, Tetsuya et. al.
Spectrophotometric and ESI-MS/HPLC studies reveal a common mechanism for the reaction of various artemisinin analogues with hemin
score: 1.4765647, Bioorganic & Medicinal Chemistry Letters, 2003, Messori, Luigi et. al.
Identification of GIYWHHY as a novel peptide substrate for human p60 c-src protein tyrosine kinase
score: 1.4763971, Bioorganic & Medicinal Chemistry, 1996, Lou, Qiang; Leftwich, Margaret E.; Lam, Kit S.
Effect of the oligo(ethylene glycol) group on the antioxidant activity of manganese salen complexes
score: 1.4763718, Bioorganic & Medicinal Chemistry Letters, 2009, Park, Wonchoul; Lim, Dongyeol
Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles
score: 1.475963, European Journal of Medicinal Chemistry, 2012, Kozic, Ján et. al.
Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles
score: 1.475963, European Journal of Medicinal Chemistry, 2012, Kozic, Ján et. al.
Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients.
score: 1.4758763, Antimicrobial agents and chemotherapy, 2012, Troke, Philip J F et. al.
Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer
score: 1.4756148, European Journal of Medicinal Chemistry, 2012, Virgilio, Antonella et. al.
Synthesis and biological activity of new 1,4-benzodioxan-arylpiperazine derivatives. Further validation of a pharmacophore model for α 1-adrenoceptor antagonists
score: 1.4755958, Bioorganic & Medicinal Chemistry, 2002, Barbaro, Roberta et. al.
Antiproliferative activity of salinomycin and its derivatives
score: 1.4755289, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam et. al.
Antiproliferative activity of salinomycin and its derivatives
score: 1.4755289, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam et. al.
Antiproliferative activity of salinomycin and its derivatives
score: 1.4755289, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam et. al.
3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate
score: 1.4754408, Bioorganic & Medicinal Chemistry, 2012, Camacho, Luz et. al.
3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate
score: 1.4754408, Bioorganic & Medicinal Chemistry, 2012, Camacho, Luz et. al.
3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate
score: 1.4754408, Bioorganic & Medicinal Chemistry, 2012, Camacho, Luz et. al.
Benzothiazoles: Search for anticancer agents
score: 1.4753821, European Journal of Medicinal Chemistry, 2012, Noolvi, Malleshappa N.; Patel, Harun M.; Kaur, Manpreet
Contemporary paradigms for cholinergic ligand design guided by biological structure
score: 1.4752292, Bioorganic & Medicinal Chemistry Letters, 2004, Taylor, Palmer et. al.
Design and total synthesis of a fluorescent phorboxazole a analog for cellular studies
score: 1.4750337, Bioorganic & Medicinal Chemistry Letters, 2006, Chen, Jiehao et. al.
CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: Reduction of CNS side effects by introducing polar functional groups
score: 1.4749651, Bioorganic & Medicinal Chemistry Letters, 2012, Odan, Masahide et. al.
Anti-formyl peptide antibodies
score: 1.4748404, Bioorganic & Medicinal Chemistry Letters, 2007, Tanaka, Fujie et. al.
Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans.
score: 1.474785, Antimicrobial agents and chemotherapy, 2005, Toenjes, Kurt A et. al.
Synthesis and structure–Activity relationships of 5,6,7,8-Tetrahydropyrido[3,4- b]pyrazine-based hydroxamic acids as HB-EGF shedding inhibitors
score: 1.4746872, Bioorganic & Medicinal Chemistry, 2003, Yoshiizumi, Kazuya et. al.
Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol
score: 1.4746869, Bioorganic & Medicinal Chemistry Letters, 2012, Khaybullin, Ravil N. et. al.
Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol
score: 1.4746869, Bioorganic & Medicinal Chemistry Letters, 2012, Khaybullin, Ravil N. et. al.
Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol
score: 1.4746869, Bioorganic & Medicinal Chemistry Letters, 2012, Khaybullin, Ravil N. et. al.
Possible ligand-receptor interactions for NK 1 antagonists as observed in their crystal structures
score: 1.4746825, Bioorganic & Medicinal Chemistry, 1997, Boks, Gertjan J.; Tollenaere, Jan P.; Kroon, Jan
d-Proline-based peptidomimetic inhibitors of anthrax lethal factor
score: 1.474669, European Journal of Medicinal Chemistry, 2012, Calugi, Chiara et. al.
d-Proline-based peptidomimetic inhibitors of anthrax lethal factor
score: 1.474669, European Journal of Medicinal Chemistry, 2012, Calugi, Chiara et. al.
Validation of a histamine H 3 receptor model through structure–activity relationships for classical H 3 antagonists
score: 1.4744996, Bioorganic & Medicinal Chemistry, 2005, Lorenzi, Simone et. al.
Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase
score: 1.4744198, Bioorganic & Medicinal Chemistry, 2005, Boa, Andrew N. et. al.
Quantitative structure-activity relationships of nicotine analogues as neuronal nicotinic acetylcholine receptor ligands
score: 1.4742283, Bioorganic & Medicinal Chemistry, 1996, Ki Hwan Kim, ; Lin, Nan-Horng; Anderson, David J.
Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-Substituent
score: 1.4741766, Bioorganic & Medicinal Chemistry, 2002, Weidner-Wells, Michele A. et. al.
Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents
score: 1.4741278, Bioorganic & Medicinal Chemistry, 2006, Lin, Li et. al.
Nonsteroidal antiinflammatory agents—part 2 antiinflammatory, analgesic and antipyretic activity of some substituted 3-pyrazolin-5-ones and 1,2,4,5,6,7-3 H-hexahydroindazol-3-ones
score: 1.4740582, European Journal of Medicinal Chemistry, 2006, El-Hawash, Soad A.M. et. al.
Sinularioside, a triacetylated glycolipid from the Indonesian soft coral Sinularia sp., is an inhibitor of NO release
score: 1.4740016, Bioorganic & Medicinal Chemistry Letters, 2012, Putra, Masteria Yunovilsa et. al.
Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors
score: 1.4738879, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Kevin K.-C. et. al.
Synthesis of carbamate-type caged derivatives of a novel glutamate transporter blocker
score: 1.4738797, Bioorganic & Medicinal Chemistry, 2004, Takaoka, Kiyo et. al.
Stereoselective syntheses of phosphorylated and sulfated glycosyl serines in glycosaminoglycan for biological probes
score: 1.4738238, Bioorganic & Medicinal Chemistry Letters, 1999, Tamura, Jun-ichi; Nishihara, Junko
Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase
score: 1.473653, Bioorganic & Medicinal Chemistry, 2003, Masubuchi, Miyako et. al.
Binding free energy calculations of adenosine deaminase inhibitors
score: 1.4736326, Bioorganic & Medicinal Chemistry, 2006, Coi, Alessio et. al.
Identification of Spirocyclic Piperidine-Azetidine Inverse Agonists of the Ghrelin Receptor
score: 1.4734558, Bioorganic & Medicinal Chemistry Letters, 2012, Kung, Daniel W. et. al.
Design, synthesis, and biological evaluation of a cephalosporin–monohydroguaiaretic acid prodrug activated by a monoclonal antibody–β-lactamase conjugate
score: 1.4734436, Bioorganic & Medicinal Chemistry, 2002, Hakimelahi, Gholam Hossein et. al.
The influence of aromatic residues in hydraphile spacer units: assay by ion selective electrode methods and in bacteria
score: 1.4733986, Bioorganic & Medicinal Chemistry, 2005, Meyer, Adam E. et. al.
Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors
score: 1.473311, Bioorganic & Medicinal Chemistry, 2005, Kalgutkar, Amit S. et. al.
Detection of 1270 nm emission from singlet oxygen and photocytotoxic property of sugar-Pendant [60] fullerenes
score: 1.473231, Bioorganic & Medicinal Chemistry Letters, 2003, Mikata, Yuji et. al.
Novel ligands for the opioid receptors: synthesis and structure–activity relationships among 5′-aryl and 5′-heteroaryl 17-cyclopropylmethyl-4,5α-epoxypyrido[2′,3′:6,7]morphinans
score: 1.4730286, Bioorganic & Medicinal Chemistry, 2003, Ananthan, Subramaniam et. al.
Structural assignment of 2,6- and 2,7-disubstituted naphthalenes and prediction of 13C nuclear magnetic resonance chemical shifts: applications of topology and two-dimensional NMR spectroscopy
score: 1.4728442, Bioorganic & Medicinal Chemistry Letters, 2002, Khadikar, Padmakar V et. al.
Natural biflavones as novel inhibitors of cathepsin B and K
score: 1.4728429, European Journal of Medicinal Chemistry, 2006, Zeng, G.-Z.; Pan, X.-L.; Tan, N.-H.; Xiong, J.; Zhang, Y.-M.
p K a and Volume of residue one influence δ/μ opioid binding: QSAR analysis of tyrosine replacement in a nonselective deltorphin analogue
score: 1.4728202, Bioorganic & Medicinal Chemistry, 2003, Heyl, Deborah L et. al.
Dihydropyrido[2,3- d]pyrimidines as a new class of antileishmanial agents
score: 1.4727892, Bioorganic & Medicinal Chemistry, 2005, Agarwal, Anu et. al.
3-Deoxy-3,4-dehydro Analogs of XM462. Preparation and Activity on Sphingolipid Metabolism and Cell Fate
score: 1.4726083, Bioorganic & Medicinal Chemistry, 2012, Camacho, Luz et. al.
Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids – Highly potent antibacterial agents
score: 1.4723918, European Journal of Medicinal Chemistry, 2012, Sangaraiah, Nagarajan et. al.
Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids – Highly potent antibacterial agents
score: 1.4723918, European Journal of Medicinal Chemistry, 2012, Sangaraiah, Nagarajan et. al.
The design, synthesis, and initial evaluation of benzophenone-containing peptides as potential photoaffinity labels of oligosaccharyltransferase
score: 1.4723453, Bioorganic & Medicinal Chemistry, 1998, Xu, Tong; Khanna, Hemant; Coward, James K.
Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative
score: 1.4723427, Bioorganic & Medicinal Chemistry, 2007, Hattori, Yoshihide et. al.
2 H-Thieno[3,2- e]- and [2,3- e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit
score: 1.4721732, Bioorganic & Medicinal Chemistry, 2000, Chen, Hwang-Hsing et. al.
Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile
score: 1.472167, Bioorganic & Medicinal Chemistry, 2012, Toba, Tetsuya et. al.
9-Carboxymethyl-5 H,10 H-imidazo[1,2- a]indeno[1,2- e]pyrazin-4-one-2-carbocylic Acid (RPR117824): Selective Anticonvulsive and Neuroprotective AMPA Antagonist
score: 1.4720413, Bioorganic & Medicinal Chemistry, 2002, Mignani, Serge et. al.
BioProfile—Extract knowledge from corporate databases to assess cross-reactivities of compounds
score: 1.471915, Bioorganic & Medicinal Chemistry, 2012, Beck, Bernd
Identification and characterization of small molecule modulators of KChIP/Kv4 function
score: 1.4718789, Bioorganic & Medicinal Chemistry, 2005, Bowlby, Mark R. et. al.
Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A 2A adenosine receptor homodimer
score: 1.4718648, Bioorganic & Medicinal Chemistry Letters, 2008, Ivanov, Andrei A.; Jacobson, Kenneth A.
Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors
score: 1.4714834, European Journal of Medicinal Chemistry, 2012, Gu, Xiaoke et. al.
Non-stochastic and stochastic linear indices of the ‘molecular pseudograph’s atom adjacency matrix’: application to ‘in silico’ studies for the rational discovery of new antimalarial compounds
score: 1.4713927, Bioorganic & Medicinal Chemistry, 2005, Marrero Ponce, Yovani et. al.
Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity
score: 1.4713712, European Journal of Medicinal Chemistry, 2012, Abonia, Rodrigo et. al.
Copper(I) mediated facile synthesis of potent tubulin polymerization inhibitor, 9-amino-α-noscapine from natural α-noscapine
score: 1.4713373, Bioorganic & Medicinal Chemistry Letters, 2012, Manchukonda, Naresh K. et. al.
Synthesis, characterization and potent DNA-cleaving activity of copper(II)-complexed berberine carboxylate
score: 1.471328, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jin-Xiang et. al.
Modified PNAs: A simple method for the synthesis of monomeric building blocks
score: 1.4713198, Bioorganic & Medicinal Chemistry Letters, 1999, Maison, Wolfgang et. al.
Interpreting the effect of methyl group at the three carbon bridge of (−)-huperzine a on its anticholinesterase activity by molecular dynamics method
score: 1.4713151, Bioorganic & Medicinal Chemistry Letters, 1998, DongXiang Liu, et. al.
Pharmacology of ionotropic glutamate receptors: A structural perspective
score: 1.4712667, Bioorganic & Medicinal Chemistry, 2010, Stawski, Philipp; Janovjak, Harald; Trauner, Dirk
Synthesis of N-substituted Clausenamide analogues
score: 1.4711385, European Journal of Medicinal Chemistry, 2010, Li, XingZhou et. al.
A carbosilane dendrimer and a silacyclopentadiene analog carrying peripheral lactoses as drug-delivery systems
score: 1.4710829, Bioorganic & Medicinal Chemistry Letters, 2012, Aizawa, Hiroaki et. al.
A carbosilane dendrimer and a silacyclopentadiene analog carrying peripheral lactoses as drug-delivery systems
score: 1.4710829, Bioorganic & Medicinal Chemistry Letters, 2012, Aizawa, Hiroaki et. al.
A carbosilane dendrimer and a silacyclopentadiene analog carrying peripheral lactoses as drug-delivery systems
score: 1.4710829, Bioorganic & Medicinal Chemistry Letters, 2012, Aizawa, Hiroaki et. al.
Design, synthesis, and evaluation of (E)-N-substituted benzylidene–aniline derivatives as tyrosinase inhibitors
score: 1.4710271, European Journal of Medicinal Chemistry, 2012, Bae, Sung Jin et. al.
Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis
score: 1.4709931, Bioorganic & Medicinal Chemistry Letters, 2012, Shen, Tao et. al.
Plant-based anticancer molecules: A chemical and biological profile of some important leads
score: 1.4707559, Bioorganic & Medicinal Chemistry, 2005, Srivastava, Vandana et. al.
Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance.
score: 1.4704903, Antimicrobial agents and chemotherapy, 2001, Hammond, J L et. al.
Synthesis and biological evaluation of new fluorine substituted derivatives as angiotensin II receptor antagonists with anti-hypertension and anti-tumor effects
score: 1.4700184, Bioorganic & Medicinal Chemistry, 2012, Da, Ya-jing et. al.
Analysis of the binding specificities of oligomannoside-binding proteins using methylated monosaccharides
score: 1.4699842, Bioorganic & Medicinal Chemistry, 1996, Chervenak, Mary C.; Toone, Eric J.
Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr
score: 1.469939, Bioorganic & Medicinal Chemistry Letters, 2012, Efdi, Mai et. al.
Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr
score: 1.469939, Bioorganic & Medicinal Chemistry Letters, 2012, Efdi, Mai et. al.
Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr
score: 1.469939, Bioorganic & Medicinal Chemistry Letters, 2012, Efdi, Mai et. al.
Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcome.
score: 1.4698732, Antimicrobial agents and chemotherapy, 2011, Wong, Rina P M et. al.
Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents
score: 1.4698451, Bioorganic & Medicinal Chemistry, 2012, Yao, Jianwen; Chen, Jing; He, Zuopeng; Sun, Wei; Xu, Wenfang
Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site
score: 1.4698381, Bioorganic & Medicinal Chemistry, 2006, Viger, Anne; Dervan, Peter B.
Synthesis of N-substituted N-nitrosohydroxylamines as inhibitors of Mushroom Tyrosinase
score: 1.4698334, Bioorganic & Medicinal Chemistry, 2001, Shiino, Mitsuhiro; Watanabe, Yumi; Umezawa, Kazuo
A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis.
score: 1.4697158, Antimicrobial agents and chemotherapy, 2012, Xu, Tao et. al.
Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides
score: 1.4695769, Bioorganic & Medicinal Chemistry, 1999, Dragovich, Peter S. et. al.
Orally active cephalosporins. Part 2: Synthesis, structure–activity relationships and oral absorption of cephalosporins having a C-3 pyridyl side chain
score: 1.4692204, Bioorganic & Medicinal Chemistry, 2000, Yamamoto, Hirofumi et. al.
Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands
score: 1.4691329, Bioorganic & Medicinal Chemistry, 2001, Mor, Marco et. al.
Formaldehyde-mediated modification of natural deoxyguanosine with amines: one-pot cyclization as a molecular model for genotoxicity
score: 1.4690964, Bioorganic & Medicinal Chemistry Letters, 2001, Takahashi, Hiroyasu; Hashimoto, Yuichi
Tobramycin-edta conjugate: A noninnocent affinity-cleaving reagent
score: 1.4689652, Bioorganic & Medicinal Chemistry Letters, 1998, Wang, Hai; Tor, Yitzhak
Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1 H-benzimidazole- N-alkylated-5-carboxamidines
score: 1.4689455, European Journal of Medicinal Chemistry, 2005, Göker, Hakan et. al.
Evaluations of substrate specificity and inhibition at PR/p3 cleavage site of HTLV-1 protease
score: 1.4685403, Bioorganic & Medicinal Chemistry Letters, 2006, Naka, Hiromi et. al.
New quinazolinone–pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies
score: 1.4684916, European Journal of Medicinal Chemistry, 2012, Abbas, Safinaz E. et. al.
Inhibition of the ser-thr phosphatases PP1 and PP2A by naturally occurring toxins
score: 1.4684835, Bioorganic & Medicinal Chemistry, 1997, Sheppeck, James E. et. al.
A simple procedure for the derivation of electron density based surfaces of drug-receptor complexes from a combination of X-ray data and theoretical calculations
score: 1.4683859, Bioorganic & Medicinal Chemistry, 2010, Mebs, Stefan; Lüth, Anja; Luger, Peter
New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides
score: 1.4683386, Bioorganic & Medicinal Chemistry, 2005, Janjic, Jelena M. et. al.
The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential.
score: 1.4683116, Antimicrobial agents and chemotherapy, 2009, François, Katrien O et. al.
A rationale for the activity profile of arylpiperazinylthioalkyls as 5-HT 1A-serotonin and α 1-adrenergic receptor ligands
score: 1.4681812, European Journal of Medicinal Chemistry, 2010, Sharma, Brij Kishore; Sarbhai, Kirti; Singh, Prithvi
QSAR study on narcotic mechanism of action and toxicity: a molecular connectivity approach to Vibrio fischeri toxicity testing
score: 1.4681745, Bioorganic & Medicinal Chemistry, 2002, Agrawal, Vijay K.; Khadikar, Padmakar V.
Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase
score: 1.4681191, Bioorganic & Medicinal Chemistry Letters, 2000, Dunsdon, Rachel M et. al.
cis-Gigantrionenin and 4-acetyl gigantetrocin A, two new bioactive annonaceous acetogenins from Goniothalamus giganteus, and the stereochemistries of acetogenin 1,2,5-triols
score: 1.4679627, Bioorganic & Medicinal Chemistry, 1996, Zeng, Lu et. al.
Cationic hydrophobic peptides with antimicrobial activity.
score: 1.4679055, Antimicrobial agents and chemotherapy, 2002, Stark, Margareta; Liu, Li-Ping; Deber, Charles M
Efficient Synthesis of ‘Redox-Switched’ Naphthoquinone Thiol-Crown Ethers and Their Biological Activity Evaluation
score: 1.4678796, Bioorganic & Medicinal Chemistry, 2002, Huang, Sheng-Tung et. al.
Benzothiazoles: Search for anticancer agents
score: 1.4678666, European Journal of Medicinal Chemistry, 2012, Noolvi, Malleshappa N.; Patel, Harun M.; Kaur, Manpreet
Solution-phase generation of tetraurea libraries
score: 1.4678379, Bioorganic & Medicinal Chemistry, 1996, Shipps, Gerald W.; Spitz, Urs P.; Julius, Rebek
CoMSIA and POM analyses of anti-malarial activity of synthetic prodiginines
score: 1.4677491, Bioorganic & Medicinal Chemistry Letters, 2012, Mahajan, Devidas T. et. al.
New synthesis of ( S)-dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethenedioxy-biphenyl-2,2′-dicarboxylate by configuration transform
score: 1.4675622, Bioorganic & Medicinal Chemistry Letters, 2004, Cheng, Sen-Xiang et. al.
Discovery of inhibitors of brassinin oxidase based on the scaffolds of the phytoalexins brassilexin and wasalexin
score: 1.4672495, Bioorganic & Medicinal Chemistry, 2010, Pedras, M. Soledade C. et. al.
Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase
score: 1.4672339, Bioorganic & Medicinal Chemistry, 2004, Hejaz, Hatem A.M et. al.
Avermectins and flea control: structure–activity relationships and the selection of selamectin for development as an endectocide for companion animals
score: 1.4671399, Bioorganic & Medicinal Chemistry, 2000, Banks, B.J. et. al.
Protein degradation with photoactivated enediyne-amino acid conjugates
score: 1.4669894, Bioorganic & Medicinal Chemistry Letters, 2002, Plourde, II, Gary et. al.
Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues
score: 1.4669577, Bioorganic & Medicinal Chemistry, 2006, Mavromoustakos, T. et. al.
Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety
score: 1.466906, Bioorganic & Medicinal Chemistry, 2005, Khatib, Soliman et. al.
Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H 3 receptor antagonists
score: 1.4668392, Bioorganic & Medicinal Chemistry, 2006, Łażewska, Dorota et. al.
Identification of the ability of highly charged nanomolar inhibitors of protein kinases to cross plasma membranes and carry a protein into cells
score: 1.4667336, Bioorganic & Medicinal Chemistry Letters, 2002, Uri, Asko et. al.
Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.
score: 1.466727, Antimicrobial agents and chemotherapy, 1999, Markham, P N et. al.
Tandem ligation at X-Cys and Gly-Gly positions via an orthogonally protected auxiliary group
score: 1.4666809, Bioorganic & Medicinal Chemistry, 2007, Spetzler, Jane C.; Hoeg-Jensen, Thomas
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.
score: 1.466645, Antimicrobial agents and chemotherapy, 2002, Balzarini, J et. al.
Antiproliferative and apoptotic effects of the oxidative dimerization product of methyl caffeate on human breast cancer cells
score: 1.4666218, Bioorganic & Medicinal Chemistry Letters, 2013, Bailly, Fabrice et. al.
New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms
score: 1.4664486, Bioorganic & Medicinal Chemistry, 2012, Carneiro, Paula F. et. al.
Cristatumins A–D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220
score: 1.4663673, Bioorganic & Medicinal Chemistry Letters, 2012, Du, Feng-Yu et. al.
Diboronic acids as fluorescent probes for cells expressing sialyl lewis X
score: 1.4663404, Bioorganic & Medicinal Chemistry Letters, 2002, Yang, Wenqian et. al.
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
score: 1.4663394, Bioorganic & Medicinal Chemistry, 2012, Okaecwe, Thokozile et. al.
Synthesis, Characterization and Biological Studies of Diosgenyl Analogues
score: 1.4661703, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Baozhan et. al.
Syntheses of glucose analogues of E5564 as a highly potent anti-sepsis drug candidate
score: 1.4661641, Bioorganic & Medicinal Chemistry, 2006, Shiozaki, Masao et. al.
Novel thiocoumarins as inhibitors of TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation
score: 1.4661262, Bioorganic & Medicinal Chemistry, 2005, Kumar, Sarvesh et. al.
Substrate specificity of galactokinase from Streptococcus pneumoniae TIGR4 towards galactose, glucose, and their derivatives
score: 1.4661131, Bioorganic & Medicinal Chemistry Letters, 2012, Zou, Yang et. al.
Substrate specificity of galactokinase from Streptococcus pneumoniae TIGR4 towards galactose, glucose, and their derivatives
score: 1.4661131, Bioorganic & Medicinal Chemistry Letters, 2012, Zou, Yang et. al.
Substrate specificity of galactokinase from Streptococcus pneumoniae TIGR4 towards galactose, glucose, and their derivatives
score: 1.4661131, Bioorganic & Medicinal Chemistry Letters, 2012, Zou, Yang et. al.
CP6679, a new injectable cephalosporin. Part1: Synthesis and structure–activity relationships
score: 1.4659955, Bioorganic & Medicinal Chemistry, 2000, Tsushima, Masaki et. al.
Synthesis and antimycobacterial activity of calpinactam derivatives
score: 1.4659812, Bioorganic & Medicinal Chemistry Letters, 2012, Nagai, Kenichiro et. al.
Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate
score: 1.4658594, Bioorganic & Medicinal Chemistry Letters, 2004, Shukla, Ruchi; Barve, Vivek; Padhye, Subhash; Bhonde, Ramesh
Synthesis and biological evaluation of PEG-tirofiban conjugates
score: 1.4658437, Bioorganic & Medicinal Chemistry Letters, 2008, Désaubry, Laurent et. al.
Isolation of 3′- O-Acetylchloramphenicol: A possible intermediate in chloramphenicol biosynthesis
score: 1.4658068, Bioorganic & Medicinal Chemistry Letters, 2002, Groß, Frank et. al.
Dendrimers in solution can have their remote catalytic groups folded back into the core: Enantioselective transaminations by dendritic enzyme mimics-II
score: 1.4657908, Bioorganic & Medicinal Chemistry Letters, 2009, Wei, Sujun et. al.
Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety
score: 1.4657047, Bioorganic & Medicinal Chemistry, 2003, Anizon, Fabrice et. al.
3-Azido-3-deoxy-glycopyranoside derivatives as scaffolds for the synthesis of carbohydrate-Based universal pharmacophore mapping libraries
score: 1.4655828, Bioorganic & Medicinal Chemistry Letters, 2003, Jain, Rakesh et. al.
Synthesis and pharmacological assessment of derivatives of isoxazolo[4,5- d]pyrimidine
score: 1.465582, Bioorganic & Medicinal Chemistry, 2004, Wagner, Edwin; Becan, Lilianna; Nowakowska, El
Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3- a]quinoxalin-1-one derivatives as potent A 2A adenosine receptor antagonists
score: 1.4655477, Bioorganic & Medicinal Chemistry, 2003, Colotta, Vittoria et. al.
Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor
score: 1.4655236, European Journal of Medicinal Chemistry, 2008, Kiss, Róbert et. al.
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors
score: 1.4655172, Bioorganic & Medicinal Chemistry, 2012, Marriott, Karla-Sue C. et. al.
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors
score: 1.4655172, Bioorganic & Medicinal Chemistry, 2012, Marriott, Karla-Sue C. et. al.
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors
score: 1.4655172, Bioorganic & Medicinal Chemistry, 2012, Marriott, Karla-Sue C. et. al.
The design of potent, non-peptidic inhibitors of hepatitis C protease
score: 1.4653036, European Journal of Medicinal Chemistry, 2003, Andrews, David M. et. al.
In vitro oxidative metabolism study of (−)-rhazinilam
score: 1.4652503, Bioorganic & Medicinal Chemistry, 2006, Décor, Anne et. al.
Synthesis and biological evaluation of 99mTc, Re-monoamine-monoamide conjugated to 2-(4-aminophenyl)benzothiazole as potential probes for β-amyloid plaques in the brain
score: 1.4652244, Bioorganic & Medicinal Chemistry Letters, 2008, Chen, Xiangji; Yu, Pingrong; Zhang, Lianfeng; Liu, Boli
In silico studies for the rational discovery of anticonvulsant compounds
score: 1.4650696, Bioorganic & Medicinal Chemistry, 2000, Estrada, Ernesto; Peña, Alfredo
Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles
score: 1.4650244, Nature chemical biology, 2011, Georghiou, George et. al.
Synthesis and ESR study of new dihydroxamic acid siderophores S as scavengers of hydroxyl radicals
score: 1.4649534, Bioorganic & Medicinal Chemistry Letters, 1998, Nguyen, M.V.D.; Nicolas, L.; Gaudemer, A.; Brik, M.E.
A new class of bioactivable self-immolative N,O-ligands
score: 1.4645812, European Journal of Medicinal Chemistry, 2012, Kuźnik, Nikodem et. al.
Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine mollusk
score: 1.4644216, Bioorganic & Medicinal Chemistry Letters, 2012, Umehara, Masahiro et. al.
Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium
score: 1.4644197, Bioorganic & Medicinal Chemistry, 2007, Núñez-Vergara, Luis J. et. al.
New bis-aminomercaptotriazoles and bis-triazolothiadiazoles as possible anticancer agents
score: 1.4642617, European Journal of Medicinal Chemistry, 2002, Shivarama Holla, B et. al.
O-(Fluoresceinylmethyl)hydroxylamine (OFMHA): A fluorescent reagent for detection of damaged nucleic acids
score: 1.4642565, Bioorganic & Medicinal Chemistry Letters, 1998, Adamczyk, Maciej; Mattingly, Phillip G; Moore, Jeffrey A
Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
score: 1.4642349, Bioorganic & Medicinal Chemistry, 2012, Herth, Matthias M. et. al.
Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil
score: 1.4640766, European Journal of Medicinal Chemistry, 2005, Omran, Ziad et. al.
Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones
score: 1.464076, European Journal of Medicinal Chemistry, 2004, Raffa, Demetrio et. al.
Antitumor activity of diethynylfluorene derivatives of gold(I)
score: 1.4640301, Bioorganic & Medicinal Chemistry, 2009, Chui, Chung-Hin et. al.
Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase
score: 1.4639914, Bioorganic & Medicinal Chemistry, 2012, Hawker, Dustin D.; Silverman, Richard B.
Quantitative structure–polarization relationships (QSPR) study of BTEX tracers for the formation of antibody–BTEX–EDF complex
score: 1.4639288, Bioorganic & Medicinal Chemistry Letters, 2004, Moon, Taesung et. al.
Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish
score: 1.4637209, European Journal of Medicinal Chemistry, 2012, Liu, Guang-Lu; Hao, Bing; Liu, Shao-Peng; Wang, Gao-Xue
Benzenesulfonamide analogs of fluoroquinolones. Antibacterial activity and QSAR studies
score: 1.4635549, European Journal of Medicinal Chemistry, 2005, Nieto, M.J.; Alovero, F.L.; Manzo, R.H.; Mazzieri, Maria R.
Sequence-selectivity of 5,11-dimethyl-5 H-indolo[2,3- b]quinoline binding to DNA. Footprinting and molecular modeling studies
score: 1.463516, Bioorganic & Medicinal Chemistry, 2000, Osiadacz, Jarosław et. al.
1,4-Anhydrogalactopyranose is not an intermediate of the mutase catalyzed UDP-galactopyranose/furanose interconversion
score: 1.4634582, Bioorganic & Medicinal Chemistry Letters, 2006, Caravano, Audrey; Sinaÿ, Pierre; Vincent, Stéphane P.
Synthesis and activities of oxidative metabolites of the anti-arthritic drug candidate S-2474
score: 1.4632361, Bioorganic & Medicinal Chemistry, 2003, Inagaki, Masanao et. al.
Combination of porphyrins and DNA-alkylation agents: Synthesis and tumor cell apoptosis induction
score: 1.4631582, Bioorganic & Medicinal Chemistry, 2006, He, Hanping et. al.
Synthesis, characterization and potent DNA-cleaving activity of copper(II)-complexed berberine carboxylate
score: 1.4631134, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jin-Xiang et. al.
Synthesis, characterization and potent DNA-cleaving activity of copper(II)-complexed berberine carboxylate
score: 1.4631134, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jin-Xiang et. al.
Synthesis, characterization and potent DNA-cleaving activity of copper(II)-complexed berberine carboxylate
score: 1.4631134, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jin-Xiang et. al.
Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
score: 1.4630011, Bioorganic & Medicinal Chemistry Letters, 2012, Srikanth Reddy, T. et. al.
The Discovery of Potent and Selective Pyridopyrimidin-7-one Based Inhibitors of B-RafV600E Kinase
score: 1.4628178, Bioorganic & Medicinal Chemistry Letters, 2012, Ren, Li et. al.
QSAR modeling of globulin binding affinity of corticosteroids using AM1 calculations
score: 1.4626842, Bioorganic & Medicinal Chemistry, 2004, De, Kakali; Sengupta, Chandana; Roy, Kunal
Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents
score: 1.4624936, Bioorganic & Medicinal Chemistry, 2012, Wiley, Jenny L. et. al.
Use of whole cell culture of Aeromonas sp. as enantioselective scavenger: A facile preparation of l-amino acid derivatives in high enantiomeric excess
score: 1.4624666, Bioorganic & Medicinal Chemistry Letters, 2009, Zhang, Zizhang
Synthesis, σ1, σ2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes
score: 1.4624118, Bioorganic & Medicinal Chemistry, 2012, Riganas, Stefanos et. al.
Synthesis, σ1, σ2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes
score: 1.4624118, Bioorganic & Medicinal Chemistry, 2012, Riganas, Stefanos et. al.
A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolidines as anti mycobacterial agents
score: 1.4622811, Bioorganic & Medicinal Chemistry Letters, 2012, Almansour, Abdulrahman I. et. al.
A new boronic acid based fluorescent reporter for catechol
score: 1.4619173, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Zhongyu; Li, Minyong; Fang, Hao; Wang, Binghe
A new boronic acid based fluorescent reporter for catechol
score: 1.4619173, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Zhongyu; Li, Minyong; Fang, Hao; Wang, Binghe
A new boronic acid based fluorescent reporter for catechol
score: 1.4619173, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Zhongyu; Li, Minyong; Fang, Hao; Wang, Binghe
Topological designing of 4-piperazinylquinazolines as antagonists of PDGFR tyrosine kinase family
score: 1.4618645, Bioorganic & Medicinal Chemistry Letters, 2003, Khadikar, Padmakar V. et. al.
Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors
score: 1.4618361, Bioorganic & Medicinal Chemistry, 2012, Moran, Matthew D. et. al.
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor
score: 1.4617733, Bioorganic & Medicinal Chemistry Letters, 2012, Kung, Daniel W. et. al.
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor
score: 1.4617733, Bioorganic & Medicinal Chemistry Letters, 2012, Kung, Daniel W. et. al.
Synthesis of chalcone derivatives as potential anti-diabetic agents
score: 1.4616737, Bioorganic & Medicinal Chemistry Letters, 2012, Hsieh, Chi-Ting et. al.
Synthesis of chalcone derivatives as potential anti-diabetic agents
score: 1.4616737, Bioorganic & Medicinal Chemistry Letters, 2012, Hsieh, Chi-Ting et. al.
Synthesis of chalcone derivatives as potential anti-diabetic agents
score: 1.4616737, Bioorganic & Medicinal Chemistry Letters, 2012, Hsieh, Chi-Ting et. al.
Development of novel 19F NMR pH indicators: synthesis and evaluation of a series of fluorinated vitamin B 6 analogues
score: 1.4616603, Bioorganic & Medicinal Chemistry, 1998, He, Sha et. al.
Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents
score: 1.4615743, Bioorganic & Medicinal Chemistry, 2003, Isobe, Yoshiaki et. al.
Deconstructing 14-phenylpropyloxymetopon: Minimal requirements for binding to mu opioid receptors
score: 1.4615219, Bioorganic & Medicinal Chemistry, 2012, Stavitskaya, Lidiya et. al.
Deconstructing 14-phenylpropyloxymetopon: Minimal requirements for binding to mu opioid receptors
score: 1.4615219, Bioorganic & Medicinal Chemistry, 2012, Stavitskaya, Lidiya et. al.
Synthesis of DNA oligonucleotides containing 5-(mercaptomethyl)-2′-deoxyuridine moieties
score: 1.4612221, Bioorganic & Medicinal Chemistry, 2006, Bornemann, Benjamin; Marx, Andreas
Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants
score: 1.461199, Bioorganic & Medicinal Chemistry, 2012, Duskova, Katerina et. al.
Aminocarbonylation route to tolvaptan
score: 1.4611824, Bioorganic & Medicinal Chemistry Letters, 2007, Torisawa, Yasuhiro et. al.
Reactive DNA. 2. Thioguanine used as a peg site for direct and specific introduction of biologically useful functional groups
score: 1.4610527, Bioorganic & Medicinal Chemistry Letters, 1998, Xu, Yao-Zhong
Singly and doubly labeled base-discriminating fluorescent oligonucleotide probes containing oxo-pyrene chromophore
score: 1.4610341, Bioorganic & Medicinal Chemistry Letters, 2010, Bag, Subhendu Sekhar et. al.
QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index
score: 1.460987, Bioorganic & Medicinal Chemistry, 2004, Thakur, Abhilash et. al.
Synthesis and hybridization property of novel 2′,5′-isoDNA mimic chiral peptide nucleic acids
score: 1.4607374, Bioorganic & Medicinal Chemistry Letters, 2003, Abdel-Aziz, Mohamed; Yamasaki, Tetsuo; Otsuka, Masami
Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives
score: 1.4606916, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Zhenhua et. al.
CoMFA of Artemisinin derivatives: effect of location and size of lattice
score: 1.4606437, Bioorganic & Medicinal Chemistry Letters, 2001, Jung, Mankil; Kim, Hanjo
Bisubstrate analogue structure–activity relationships for p300 histone acetyltransferase inhibitors
score: 1.4605898, Bioorganic & Medicinal Chemistry, 2004, Sagar, Vatsala et. al.
Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.
score: 1.460559, Antimicrobial agents and chemotherapy, 1998, Takei, M; Fukuda, H; Yasue, T; Hosaka, M; Oomori, Y
Synthesis of Chalcone Derivatives as Potential Anti-diabetic Agents
score: 1.4605484, Bioorganic & Medicinal Chemistry Letters, 2012, Hsieh, Chi-Ting et. al.
Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents
score: 1.4603326, Bioorganic & Medicinal Chemistry, 2004, Adams, Brian K. et. al.
A carbon–carbon-coupled dimeric bergenin derivative biotransformed by Pleurotus ostreatus
score: 1.4603226, Bioorganic & Medicinal Chemistry Letters, 2005, Wang, Dong; Zhu, Hong-Tao; Zhang, Ying-Jun; Yang, Chong-Ren
Conformational analysis of a covalently cross-linked Watson–Crick base pair model
score: 1.4602486, Bioorganic & Medicinal Chemistry Letters, 2008, Jensen, Erik A. et. al.
Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones
score: 1.4600462, Bioorganic & Medicinal Chemistry, 2006, Drabczyńska, Anna et. al.
Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells
score: 1.4600278, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Rui et. al.
Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells
score: 1.4600278, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Rui et. al.
Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells
score: 1.4600278, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Ying-Rui et. al.
Efficient system for the preparation of [ 13N]labeled nitrosamines
score: 1.4599856, Bioorganic & Medicinal Chemistry Letters, 2009, Gómez-Vallejo, Vanessa et. al.
Structure–activity relationships of epolactaene analogs as DNA polymerases inhibitors
score: 1.4599599, Bioorganic & Medicinal Chemistry, 2004, Kuramochi, Kouji et. al.
ortho Substituent effects on the anticonvulsant properties of 4-hydroxy-trifluoroethyl phenols
score: 1.4598915, Bioorganic & Medicinal Chemistry Letters, 2012, Mishra, Rajesh K.; Baker, Max T.
In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates
score: 1.4598311, Bioorganic & Medicinal Chemistry, 2012, Dang, Hung The et. al.
Synthesis, characterization and cytotoxicity of platinum(II)/palladium(II) complexes with 1,3-diaminopropane and 4-toluensulfonyl-l-amino acid dianion
score: 1.4598193, European Journal of Medicinal Chemistry, 2012, Zhang, Jinchao et. al.
Synthesis, characterization and cytotoxicity of platinum(II)/palladium(II) complexes with 1,3-diaminopropane and 4-toluensulfonyl-l-amino acid dianion
score: 1.4598193, European Journal of Medicinal Chemistry, 2012, Zhang, Jinchao et. al.
Synthesis, characterization and cytotoxicity of platinum(II)/palladium(II) complexes with 1,3-diaminopropane and 4-toluensulfonyl-l-amino acid dianion
score: 1.4598193, European Journal of Medicinal Chemistry, 2012, Zhang, Jinchao et. al.
Anti-aids agents—XXVI. Structure-activity correlations of Gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues
score: 1.4597166, Bioorganic & Medicinal Chemistry, 1997, Chen, Dao-Feng et. al.
Anti-aids agents—XXVI. Structure-activity correlations of Gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues
score: 1.4597166, Bioorganic & Medicinal Chemistry, 1997, Chen, Dao-Feng et. al.
TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity
score: 1.4596816, Bioorganic & Medicinal Chemistry, 2002, Hori, Hitoshi et. al.
Alteration of cross-linking selectivity with the 2′-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects
score: 1.4596443, Bioorganic & Medicinal Chemistry Letters, 2010, Imoto, Shuhei et. al.
A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2- 2H 3]-salvinorin A
score: 1.4593865, Bioorganic & Medicinal Chemistry Letters, 2004, Tidgewell, Kevin et. al.
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist
score: 1.4593763, European Journal of Medicinal Chemistry, 2012, Fumagalli, Laura et. al.
QSAR Studies on Carbonic Anhydrase Inhibitors: A Case of Ureido and Thioureido Derivatives of Aromatic/Heterocyclic Sulfonamides
score: 1.4592952, Bioorganic & Medicinal Chemistry, 2002, Agrawal, Vijay K.; Sharma, Ruchi; Khadikar, Padmakar V.
Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia
score: 1.4589859, Bioorganic & Medicinal Chemistry, 2006, Su, Bao-Ning et. al.
Drug Guru: A computer software program for drug design using medicinal chemistry rules
score: 1.4589219, Bioorganic & Medicinal Chemistry, 2006, Stewart, Kent D.; Shiroda, Melisa; James, Craig A.
Synthesis, toxicity and biodistribution of two 5,15-di[3,5-( nido-carboranylmethyl)phenyl]porphyrins in EMT-6 tumor bearing mice
score: 1.4588634, Bioorganic & Medicinal Chemistry, 2003, Vicente, M.Graça H et. al.
Organotin(IV) complexes of 2-pyridineformamide-derived thiosemicarbazones: Antimicrobial and cytotoxic effects
score: 1.4586641, European Journal of Medicinal Chemistry, 2008, Mendes, Isolda C. et. al.
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: Introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents
score: 1.4583898, Bioorganic & Medicinal Chemistry Letters, 2012, Deskus, Jeffrey A. et. al.
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: Introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents
score: 1.4583898, Bioorganic & Medicinal Chemistry Letters, 2012, Deskus, Jeffrey A. et. al.
8-Quinolinamines conjugated with amino acids are exhibiting potent blood-schizontocidal antimalarial activities
score: 1.4583426, Bioorganic & Medicinal Chemistry, 2004, Vangapandu, Suryanarayana et. al.
Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against Adenovirus
score: 1.4581421, European Journal of Medicinal Chemistry, 2004, Uckun, Fatih M. et. al.
Synthesis of chalcone analogues with increased antileishmanial activity
score: 1.4580838, Bioorganic & Medicinal Chemistry, 2006, Boeck, Paula et. al.
Potassium channel activators based on the benzopyran substructure: synthesis and activity of the C-8 substituent
score: 1.4578728, Bioorganic & Medicinal Chemistry, 2003, Thompson, Rona; Doggrell, Sheila; Hoberg, John O
Interaction of bulged DNA with leucine-containing mimics of NCS-chrom
score: 1.4578527, Bioorganic & Medicinal Chemistry Letters, 2006, Xi, Zhen; Ouyang, Di; Mu, Hong-Tao
Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives
score: 1.4576869, European Journal of Medicinal Chemistry, 2003, Na, Young-Min et. al.
Synthesis, characterization and biological studies of diosgenyl analogues
score: 1.4574336, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Baozhan et. al.
Synthesis, characterization and biological studies of diosgenyl analogues
score: 1.4574336, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Baozhan et. al.
Synthesis, characterization and biological studies of diosgenyl analogues
score: 1.4574336, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Baozhan et. al.
Nuclease resistant hammerhead motif: From ‘5-ribo’ to ‘3-ribo’ model
score: 1.4566997, Bioorganic & Medicinal Chemistry Letters, 1999, Matulic-Adamic, Jasenka et. al.
Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-Labeled ligand for diagnostic imaging
score: 1.4566355, Bioorganic & Medicinal Chemistry, 2002, Lashley, Matthew R et. al.
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea
score: 1.4566242, Bioorganic & Medicinal Chemistry Letters, 2012, Youn, Ui Joung et. al.
( S)-Camphorsulfonic acid catalyzed highly stereoselective synthesis of pseudoglycosides
score: 1.4565996, Bioorganic & Medicinal Chemistry Letters, 2009, Gorityala, Bala Kishan et. al.
Synthesis, acute toxicities, and antitumor effects of novel 9-substituted β-carboline derivatives
score: 1.4565735, Bioorganic & Medicinal Chemistry, 2004, Cao, Rihui et. al.
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists
score: 1.4563532, Bioorganic & Medicinal Chemistry Letters, 2012, Chakka, Nagasree et. al.
New palladium(II) complexes of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones
score: 1.4559038, Bioorganic & Medicinal Chemistry, 2003, Bharti, Neelam et. al.
Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents
score: 1.4558469, European Journal of Medicinal Chemistry, 2012, Shaaban, Saad et. al.
Design and synthesis of biotin-tagged photoaffinity probes of jasmonates
score: 1.4556124, Bioorganic & Medicinal Chemistry, 2010, Gu, Min et. al.
Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish
score: 1.4553818, European Journal of Medicinal Chemistry, 2012, Liu, Guang-Lu; Hao, Bing; Liu, Shao-Peng; Wang, Gao-Xue
Simplified bicyclic pyridinol analogues protect mitochondrial function
score: 1.4553753, Bioorganic & Medicinal Chemistry, 2012, Cai, Xiaoqing et. al.
InChI-based optimal descriptors: QSAR analysis of fullerene[C60]-based HIV-1 PR inhibitors by correlation balance
score: 1.455174, European Journal of Medicinal Chemistry, 2010, Toropov, Andrey A. et. al.
In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity.
score: 1.4550459, Antimicrobial agents and chemotherapy, 2004, Barnard, D L et. al.
Potent small molecule Hedgehog agonists induce VEGF expression in vitro
score: 1.4548911, Bioorganic & Medicinal Chemistry, 2012, Seifert, Katrin et. al.
Potent small molecule Hedgehog agonists induce VEGF expression in vitro
score: 1.4548911, Bioorganic & Medicinal Chemistry, 2012, Seifert, Katrin et. al.
Molecular orbital differentiation of agonist and antagonist activity in the Glycine B-iGluR-NMDA receptor
score: 1.4546495, European Journal of Medicinal Chemistry, 2009, Yosa, J.; Blanco, M.; Acevedo, O.; Lareo, L.R.
Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2
score: 1.4545969, Bioorganic & Medicinal Chemistry, 2010, Splain, Rebecca A.; Kiessling, Laura L.
Assessment of new 2′- O-acetalester protecting groups for regular RNA synthesis and original 2′-modified proRNA
score: 1.4544247, Bioorganic & Medicinal Chemistry Letters, 2009, Martin, Anthony R. et. al.
Interaction of heterocyclic thiols/thiones eliminated from cephalosporins with iodine and its biological implications
score: 1.4544182, Bioorganic & Medicinal Chemistry Letters, 2010, Tamilselvi, A.; Mugesh, Govindasamy
Synthesis and structure–activity relationships of the halovirs, antiviral natural products from a marine-derived fungus
score: 1.4542973, Bioorganic & Medicinal Chemistry, 2004, Rowley, David C. et. al.
2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the parp inhibitor 5-bromoisoquinolinone
score: 1.4542694, Bioorganic & Medicinal Chemistry Letters, 1999, Parveen, Ifat et. al.
Small molecule functional analogs of peptides that inhibit λ site-specific recombination and bind Holliday junctions
score: 1.4540139, Bioorganic & Medicinal Chemistry Letters, 2010, Ranjit, Dev K. et. al.
Synthesis, structure and anticancer activity of novel alkenyl-1,3,5-triazine derivatives
score: 1.4539868, European Journal of Medicinal Chemistry, 2006, Sączewski, F.; Bułakowska, A.
Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT
score: 1.4539849, Bioorganic & Medicinal Chemistry, 2008, Easson, Michael W. et. al.
Novel isoxazole polycyclic aromatic hydrocarbons as DNA-intercalating agents
score: 1.4539633, European Journal of Medicinal Chemistry, 2012, Rescifina, Antonio et. al.
Piperidino-Hydrocarbon compounds as novel non-Imidazole histamine H 3-Receptor antagonists
score: 1.4539614, Bioorganic & Medicinal Chemistry, 2002, Meier, Galina et. al.
Recent developments and biological activities of thiazolidinone derivatives: A review
score: 1.4539092, Bioorganic & Medicinal Chemistry, 2012, Jain, Abhishek Kumar et. al.
Recent developments and biological activities of thiazolidinone derivatives: A review
score: 1.4539092, Bioorganic & Medicinal Chemistry, 2012, Jain, Abhishek Kumar et. al.
Recent developments and biological activities of thiazolidinone derivatives: A review
score: 1.4539092, Bioorganic & Medicinal Chemistry, 2012, Jain, Abhishek Kumar et. al.
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as cysteine conformationally restricted analogue. synthetic protocol for Adt containing peptides
score: 1.4537753, Bioorganic & Medicinal Chemistry Letters, 2000, Morera, Enrico et. al.
Impact of protein binding cavity volume (PCV) and ligand volume (LV) in rigid and flexible docking of protein–ligand complexes
score: 1.4537249, Bioorganic & Medicinal Chemistry Letters, 2012, Saranya, N.; Jeyakanthan, J.; Selvaraj, S.
Impact of protein binding cavity volume (PCV) and ligand volume (LV) in rigid and flexible docking of protein–ligand complexes
score: 1.4537249, Bioorganic & Medicinal Chemistry Letters, 2012, Saranya, N.; Jeyakanthan, J.; Selvaraj, S.
Impact of protein binding cavity volume (PCV) and ligand volume (LV) in rigid and flexible docking of protein–ligand complexes
score: 1.4537249, Bioorganic & Medicinal Chemistry Letters, 2012, Saranya, N.; Jeyakanthan, J.; Selvaraj, S.
Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptor
score: 1.4535949, Bioorganic & Medicinal Chemistry, 2012, Qian, Wangke et. al.
Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptor
score: 1.4535949, Bioorganic & Medicinal Chemistry, 2012, Qian, Wangke et. al.
A facile route to dynamic glycopeptide libraries based on disulfide-linked sugar–peptide coupling
score: 1.4535049, Bioorganic & Medicinal Chemistry Letters, 2004, Sando, Shinsuke; Narita, Atsushi; Aoyama, Yasuhiro
Phe and Asn side chains in DNA double strands
score: 1.4532289, Bioorganic & Medicinal Chemistry Letters, 2000, Diederichsen, Ulf; Biro, Claudia M
Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme.
score: 1.4530505, Antimicrobial agents and chemotherapy, 2005, Uchiyama, Nahoko et. al.
Studies on synthesis and activation mechanism of mitomycin dimers connected by 1,2-dithiolane and diol linkers
score: 1.4530364, Bioorganic & Medicinal Chemistry, 2012, Kim, Hyoung Rae et. al.
Studies on quinones. Part 39: Synthesis and leishmanicidal activity of acylchloroquinones and hydroquinones
score: 1.4527853, Bioorganic & Medicinal Chemistry, 2005, Valderrama, Jaime A. et. al.
Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives
score: 1.4525928, Bioorganic & Medicinal Chemistry, 2012, Zhang, Li-Rong et. al.
Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives
score: 1.4525928, Bioorganic & Medicinal Chemistry, 2012, Zhang, Li-Rong et. al.
Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives
score: 1.4525928, Bioorganic & Medicinal Chemistry, 2012, Zhang, Li-Rong et. al.
Synthesis of Isomeric 3-Piperidinyl and 3-Pyrrolidinyl Benzo[5,6]cyclohepta[1,2-b]pyridines: Sulfonamido Derivatives as Inhibitors of Ras Prenylation
score: 1.4524467, Bioorganic & Medicinal Chemistry, 1998, Kelly, Joseph et. al.
Polymer-Assisted horner–Emmons olefination using PASSflow reactors: pure products without purification
score: 1.4522878, Bioorganic & Medicinal Chemistry Letters, 2002, Solodenko, Wladimir et. al.
Novel fluorescent ceramide derivatives for probing ceramidase substrate specificity
score: 1.4522619, Bioorganic & Medicinal Chemistry, 2012, Bhabak, Krishna P. et. al.
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress
score: 1.4522328, European Journal of Medicinal Chemistry, 2012, Chavarría, Cecilia et. al.
Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues
score: 1.4520892, Bioorganic & Medicinal Chemistry, 2005, León, Rafael et. al.
Synthesis and antitrichinellosis activity of some 2-substituted-[1,3]thiazolo[3,2- a]benzimidazol-3(2 H)-ones
score: 1.4520438, Bioorganic & Medicinal Chemistry, 2005, Mavrova, Anelia Ts. et. al.
Structure–activity studies with ring E analogues of methyllycaconitine. Synthesis and evaluation of enantiopure isomers of selective antagonist at the α3 nicotinic receptor
score: 1.4520285, European Journal of Medicinal Chemistry, 2002, Ismail, K.A; Bergmeier, S.C
Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione
score: 1.4519713, European Journal of Medicinal Chemistry, 2004, Kim, Bok Young et. al.
Methyltrioxorhenium: a new catalyst for the activation of hydrogen peroxide to the oxidation of lignin and lignin model compounds
score: 1.4519677, Bioorganic & Medicinal Chemistry, 2005, Crestini, Claudia et. al.
An antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus.
score: 1.4519361, Antimicrobial agents and chemotherapy, 2012, Campbell, Jennifer et. al.
Design, synthesis and antiviral activity of novel pyridazines
score: 1.4517752, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
Synthesis and in vitro biological evaluation of lipophilic cation conjugated photosensitizers for targeting mitochondria
score: 1.4517675, Bioorganic & Medicinal Chemistry, 2013, Rajaputra, Pallavi et. al.
Penicillin inhibitors of purple acid phosphatase
score: 1.4517562, Bioorganic & Medicinal Chemistry Letters, 2012, Faridoon, et. al.
In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride
score: 1.4512941, Bioorganic & Medicinal Chemistry Letters, 2004, Zsila, Ferenc et. al.
Synthesis and antitumor acitivity of novel quinazoline derivatives containing thiosemicarbazide moiety
score: 1.4512643, European Journal of Medicinal Chemistry, 2012, He, Junbo et. al.
Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons
score: 1.4512383, Bioorganic & Medicinal Chemistry, 1996, Makhey, Darshan et. al.
Chemiluminescent acridinium-9-carboxamide boronic acid probes: Application to a homogeneous glycated hemoglobin assay
score: 1.4512068, Bioorganic & Medicinal Chemistry Letters, 2006, Adamczyk, Maciej et. al.
Synthesis and biological evaluation of new 1,5-diazaanthraquinones with cytotoxic activity
score: 1.4511251, Bioorganic & Medicinal Chemistry, 2004, Manzanaro, Sonia et. al.
The aggregation and G-quadruplex DNA selectivity of charged 3,4,9,10-perylenetetracarboxylic acid diimides
score: 1.4510522, Bioorganic & Medicinal Chemistry Letters, 2002, Kern, Jonathan T.; Kerwin, Sean M.
Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors
score: 1.4507968, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Kevin K.-C. et. al.
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities
score: 1.4504485, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Sheo B. et. al.
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities
score: 1.4504485, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Sheo B. et. al.
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities
score: 1.4504485, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Sheo B. et. al.
Sentulic acid: a cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr
score: 1.4503725, Bioorganic & Medicinal Chemistry Letters, 2012, Efdi, Mai et. al.
Rapid synthesis of a 5′-fluorinated oligodeoxy-nucleotide: A model antisense probe for use in imaging with positron emission tomography (PET)
score: 1.4502161, Bioorganic & Medicinal Chemistry Letters, 1998, Pan, Dongfeng et. al.
A selective ‘ Off–On’ fluorescent sensor for Zn 2+ based on hydrazone–pyrene derivative and its application for imaging of intracellular Zn 2+
score: 1.450139, Bioorganic & Medicinal Chemistry Letters, 2010, Zhou, Ying; Kim, Ha Na; Yoon, Juyoung
Novel use of a guanosine prodrug approach to convert 2',3'-didehydro-2',3'-dideoxyguanosine into a viable antiviral agent.
score: 1.4501119, Antimicrobial agents and chemotherapy, 2002, Ray, Adrian S et. al.
Synthesis and cytotoxic activity evaluation of indolo-, pyrrolo-, and benzofuro-quinolin-2(1 H)-ones and 6-anilinoindoloquinoline derivatives
score: 1.4500925, Bioorganic & Medicinal Chemistry, 2002, Chen, Yeh-Long et. al.
Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N′-[(4-Y-phenyl)methylene]-1 H-pyrazole-4-carbohydrazides
score: 1.4500811, European Journal of Medicinal Chemistry, 2006, Bernardino, Alice M.R. et. al.
α1-Adrenoceptor subtype selectivity: Molecular modelling and theoretical quantitative structure—affinity relationships
score: 1.4500343, Bioorganic & Medicinal Chemistry, 1997, De Benedetti, P.G. et. al.
Evaluation of rat intestinal absorption data and correlation with human intestinal absorption
score: 1.4499977, European Journal of Medicinal Chemistry, 2003, Zhao, Yuan H et. al.
Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities
score: 1.4499938, Bioorganic & Medicinal Chemistry Letters, 2004, Ahn, Chan Mug et. al.
A new approach to the synthesis of efaroxan
score: 1.4499426, Bioorganic & Medicinal Chemistry Letters, 1999, Couture, K.; Gouverneur, V.; Mioskowski, C.
Syntheses of two enantiomeric pairs of myo-inositol(1,2,4,5,6) and -(1,2,3,4,5) pentakisphosphate
score: 1.4497973, Bioorganic & Medicinal Chemistry Letters, 1998, Chung, Sung-Kee et. al.
3-(1′,1′-Dimethylbutyl)-1-deoxy-Δ 8-THC and related compounds: synthesis of selective ligands for the CB 2 receptor
score: 1.4497259, Bioorganic & Medicinal Chemistry, 1999, Huffman, John W. et. al.
Solution-phase synthesis of novel Δ 2-isoxazoline libraries via 1,3-dipolar cycloaddition and their antifungal properties
score: 1.4495035, Bioorganic & Medicinal Chemistry, 2003, Basappa, et. al.
Structure–activity relationships for dipeptide prodrugs of acyclovir: Implications for prodrug design
score: 1.4494978, European Journal of Medicinal Chemistry, 2009, Santos, Cledir R. et. al.
Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro.
score: 1.4494406, Antimicrobial agents and chemotherapy, 2012, Lepist, Eve-Irene et. al.
Total synthesis of a biotinylated derivative of phorboxazole A via sonogashira coupling
score: 1.4493452, Bioorganic & Medicinal Chemistry Letters, 2003, Hansen, T.Matthew; Engler, Mary M.; Forsyth, Craig J.
Genetic Environment and Stability of cfr in Methicillin-Resistant Staphylococcus aureus CM05.
score: 1.4493421, Antimicrobial agents and chemotherapy, 2012, Locke, Jeffrey B et. al.
The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.
score: 1.4493211, Antimicrobial agents and chemotherapy, 2004, Dow, Geoffrey S et. al.
Asymmetric synthesis of novel α-amino acids with β-branched side chains
score: 1.4492748, Bioorganic & Medicinal Chemistry Letters, 2007, Zhang, Minsheng et. al.
Synthetic menthyl α/β-(1→6)-diglucopyranosides-induced cell death in human leukemia cells is dependent on caspases
score: 1.4491248, Bioorganic & Medicinal Chemistry Letters, 2012, Marrero, María Teresa et. al.
Synthetic menthyl α/β-(1→6)-diglucopyranosides-induced cell death in human leukemia cells is dependent on caspases
score: 1.4491248, Bioorganic & Medicinal Chemistry Letters, 2012, Marrero, María Teresa et. al.
Synthetic menthyl α/β-(1→6)-diglucopyranosides-induced cell death in human leukemia cells is dependent on caspases
score: 1.4491248, Bioorganic & Medicinal Chemistry Letters, 2012, Marrero, María Teresa et. al.
Screening and characterization of a chemical regulator for plant disease resistance
score: 1.44909, Bioorganic & Medicinal Chemistry Letters, 2012, Seo, Eun-Kyung et. al.
1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety
score: 1.4490616, Bioorganic & Medicinal Chemistry, 2005, Budriesi, Roberta et. al.
Synthesis of Norlignans and in vitro Inhibitory Activity of Antigen-Induced Degranulation
score: 1.4489994, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Eonjeong et. al.
Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages
score: 1.4489772, Bioorganic & Medicinal Chemistry Letters, 2012, Efthymiou, Tim C. et. al.
New 1,2,3,9-tetrahydro-4 H-carbazol-4-one derivatives: Analogues of HEAT as ligands for the α 1-adrenergic receptor subtypes
score: 1.4487481, Bioorganic & Medicinal Chemistry, 2006, Romeo, Giuseppe et. al.
Synthesis and antitumor activity of formononetin nitrogen mustard derivatives
score: 1.4487462, European Journal of Medicinal Chemistry, 2012, Ren, Jie et. al.
Computational evidence for the ligand selectivity to the α4β2 and α3β4 nicotinic acetylcholine receptors
score: 1.4487135, Bioorganic & Medicinal Chemistry, 2006, Yuan, Hongbin; Petukhov, Pavel A.
Comparative QSAR studies on bibenzimidazoles and terbenzimidazoles inhibiting topoisomerase I
score: 1.448355, Bioorganic & Medicinal Chemistry, 2001, Mekapati, Suresh Babu; Hansch, Corwin
Design and synthesis of an orally active matrix metalloproteinase inhibitor
score: 1.4482461, Bioorganic & Medicinal Chemistry, 2006, Yamamoto, Shingo et. al.
Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-amyloid plaques in brain
score: 1.4481999, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xuedan et. al.
Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-amyloid plaques in brain
score: 1.4481999, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xuedan et. al.
Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-amyloid plaques in brain
score: 1.4481999, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xuedan et. al.
Inhibitory mode of indole-2-carboxamide derivatives against HLGPa: molecular docking and 3D-QSAR analyses
score: 1.4481896, Bioorganic & Medicinal Chemistry, 2004, Liu, Guixia et. al.
Synthesis and antimycobacterial evaluation of various 7-substituted ciprofloxacin derivatives
score: 1.448119, Bioorganic & Medicinal Chemistry, 2005, Sriram, Dharmarajan et. al.
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists
score: 1.4480328, Bioorganic & Medicinal Chemistry, 2006, Chiba, Jun et. al.
Design and synthesis of a selective EP4-Receptor agonist. Part 1: discovery of 3,7-DithiaPGE 1 derivatives and identification of Their ω chains
score: 1.4479453, Bioorganic & Medicinal Chemistry, 2002, Maruyama, Toru et. al.
Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites
score: 1.4479249, Bioorganic & Medicinal Chemistry, 2002, Pizarro, Nieves et. al.
Synthesis and biological evaluation of some 6-arylamidomorphines as analogues of morphine-6-glucuronide
score: 1.4477648, Bioorganic & Medicinal Chemistry, 2004, MacDougall, James M. et. al.
Discovery of 4′-azido-2′-deoxy-2′-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication
score: 1.4477632, Bioorganic & Medicinal Chemistry Letters, 2012, Nilsson, Magnus et. al.
Functionalization of a viscosity-sensitive fluorophore for probing of biological systems
score: 1.447614, Bioorganic & Medicinal Chemistry Letters, 1998, Petrič, Andrej; Jacobson, Andrew F.; Barrio, Jorge R.
Synthesis and anticancer activity of 2-amino-8-chloro-5,5-dioxo[1,2,4]triazolo[2,3- b][1,4,2]benzodithiazine derivatives
score: 1.4473937, Bioorganic & Medicinal Chemistry, 2003, Pomarnacka, Elżbieta; Gdaniec, Maria
Predicting stability of Arc repressor mutants with protein stochastic moments
score: 1.4473481, Bioorganic & Medicinal Chemistry, 2005, González-Díaz, Humberto et. al.
Effect of stereochemistry on the transport of Aca-linked β-turn peptidomimetics across a human intestinal cell line
score: 1.4472806, Bioorganic & Medicinal Chemistry, 1997, Tamura, Kiyoshi et. al.
Genetic and biochemical characterization of FUS-1 (OXA-85), a narrow-spectrum class D beta-lactamase from Fusobacterium nucleatum subsp. polymorphum.
score: 1.4472481, Antimicrobial agents and chemotherapy, 2006, Voha, Christine et. al.
Stereoselective inhibition of glutamate carboxypeptidase by chiral phosphonothioic acids
score: 1.4472359, Bioorganic & Medicinal Chemistry, 2001, Lu, Haiyan; Berkman, Clifford E
Synthesis and antiandrogenic activity of some new 3-substituted androstano[17,16- c]-5′-aryl-pyrazoline and their derivatives
score: 1.4471325, Bioorganic & Medicinal Chemistry, 2006, Amr, Abd El-Galil E. et. al.
Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation
score: 1.4471164, Bioorganic & Medicinal Chemistry Letters, 2006, Gouda, Hiroaki et. al.
Synthesis and evaluation of uterine relaxant activity for a novel series of substituted p-hydroxyphenylethanolamines
score: 1.4470645, Bioorganic & Medicinal Chemistry, 2006, Viswanathan, C.L.; Chaudhari, A.S.
Fluorescent nitrile-based inhibitors of cysteine cathepsins
score: 1.4469819, Bioorganic & Medicinal Chemistry Letters, 2012, Frizler, Maxim; Mertens, Matthias D.; Gütschow, Michael
Fluorescent nitrile-based inhibitors of cysteine cathepsins
score: 1.4469819, Bioorganic & Medicinal Chemistry Letters, 2012, Frizler, Maxim; Mertens, Matthias D.; Gütschow, Michael
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule
score: 1.4466858, Bioorganic & Medicinal Chemistry Letters, 2013, Melancon, Bruce J. et. al.
Suppressive effects of coumarins from Mammea siamensis on inducible nitric oxide synthase expression in RAW264.7 cells
score: 1.4466851, Bioorganic & Medicinal Chemistry, 2012, Morikawa, Toshio et. al.
Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor.
score: 1.446643, Antimicrobial agents and chemotherapy, 2012, Kaplan, Nachum et. al.
Synthesis of new series of 1-Aryl-1,4-dihydro-4-oxo-6-methyl pyridazine-3-carboxylic acid as potential antibacterial agents
score: 1.4465202, European Journal of Medicinal Chemistry, 2005, Nagawade, Rahul R. et. al.
The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia
score: 1.44652, Bioorganic & Medicinal Chemistry Letters, 2012, Ho, Ginny D. et. al.
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases
score: 1.4465024, Bioorganic & Medicinal Chemistry, 1999, Lee, Younghee et. al.
Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine-5-carbonitrile derivatives
score: 1.44634, Bioorganic & Medicinal Chemistry, 2006, Cocco, Maria T. et. al.
Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O→ N intramolecular acyl migration: Design, synthesis and kinetic study
score: 1.4462934, Bioorganic & Medicinal Chemistry, 2004, Hamada, Yoshio et. al.
Synthesis of neplanocin F analogues as potential antiviral agents
score: 1.4462218, Bioorganic & Medicinal Chemistry, 2006, Zhang, Hongwang; Schinazi, Raymond F.; Chu, Chung K.
Role of the C8gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity
score: 1.4460862, Bioorganic & Medicinal Chemistry Letters, 2012, Keck, Gary E. et. al.
Synthesis and structure–antifungal activity Relationships of 3-Aryl-5-alkyl-2,5-dihydrofuran-2-ones and Their Carbanalogues: further refinement of tentative pharmacophore group
score: 1.4459288, Bioorganic & Medicinal Chemistry, 2003, Pour, Milan et. al.
Molecular modeling of non-covalent binding of homochiral (3 S,3′ S)-astaxanthin to matrix metalloproteinase-13 (MMP-13)
score: 1.4457992, Bioorganic & Medicinal Chemistry, 2006, Bikádi, Zsolt et. al.
Pharmacokinetic evaluation of the penetration of antituberculosis agents in rabbit pulmonary lesions.
score: 1.4457967, Antimicrobial agents and chemotherapy, 2012, Kjellsson, Maria C et. al.
Synthesis and optimization of hyaluronic acid–methotrexate conjugates to maximize benefit in the treatment of osteoarthritis
score: 1.4457053, Bioorganic & Medicinal Chemistry, 2010, Homma, Akie et. al.
Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.
score: 1.4456929, Antimicrobial agents and chemotherapy, 1998, Del Poeta, M et. al.
Identifying inhibitors of the SARS coronavirus proteinase
score: 1.4456753, Bioorganic & Medicinal Chemistry Letters, 2003, Jenwitheesuk, Ekachai; Samudrala, Ram
Natural products-based insecticidal agents 7. Semisynthesis and insecticidal activity of novel 4α-alkyloxy-2-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo
score: 1.445431, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Hui; Xiao, Xiao; Wang, Qing-tian
Design, Synthesis and Antiviral Activity of Novel Quinazolinones
score: 1.4453492, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
Liquid phase synthesis of arylamines and its application to the benzimidazolone via nucleophilic aryl substitution
score: 1.4453008, Bioorganic & Medicinal Chemistry Letters, 1999, Pi-Chi Pan, ; Chung-Ming Sun,
Resistance to glycopeptide antibiotics in the teicoplanin producer is mediated by van gene homologue expression directing the synthesis of a modified cell wall peptidoglycan.
score: 1.4452874, Antimicrobial agents and chemotherapy, 2007, Beltrametti, Fabrizio et. al.
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
score: 1.4450481, Antimicrobial agents and chemotherapy, 2006, Prichard, Mark N et. al.
Syntheses of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents
score: 1.4448452, Bioorganic & Medicinal Chemistry, 1999, Zhao, Shikai et. al.
Synthesis of reduced collagen crosslinks
score: 1.4447312, Bioorganic & Medicinal Chemistry Letters, 1999, van den Nieuwendijk, Adrianus M.C.H et. al.
Synthesis and histamine H 3 receptor activity of 4-( n-alkyl)-1 H-imidazoles and 4-(ω-phenylalkyl)-1 H-imidazoles
score: 1.4445251, Bioorganic & Medicinal Chemistry, 1999, De Esch, Iwan J.P et. al.
Antimicrobial peptides containing unnatural amino acid exhibit potent bactericidal activity against ESKAPE pathogens
score: 1.4443697, Bioorganic & Medicinal Chemistry, 2013, Hicks, R.P.; Abercrombie, J.J.; Wong, R.K.; Leung, K.P.
Antimicrobial and antitumor activity of n-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines
score: 1.4443509, Bioorganic & Medicinal Chemistry, 2002, Baraldi, Pier Giovanni et. al.
Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections
score: 1.4442912, Bioorganic & Medicinal Chemistry, 2003, Fakhfakh, Mohammed A. et. al.
Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype typhimurium DT104 from French patients.
score: 1.4442602, Antimicrobial agents and chemotherapy, 1999, Poirel, L; Guibert, M; Bellais, S; Naas, T; Nordmann, P
Synthesis and pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT
score: 1.4441146, Bioorganic & Medicinal Chemistry, 1999, Homan, Evert J. et. al.
5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4
score: 1.4440855, European Journal of Medicinal Chemistry, 2012, Vitale, Gabriella et. al.
Anti-human immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives.
score: 1.4440605, Antimicrobial agents and chemotherapy, 2012, Ordonez, Paula et. al.
Novel substituted 9-norbornylpurines and their activities against RNA viruses
score: 1.4440207, Bioorganic & Medicinal Chemistry Letters, 2012, Šála, Michal et. al.
Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety
score: 1.443992, European Journal of Medicinal Chemistry, 2012, Adhikari, Adithya et. al.
Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria
score: 1.443912, Bioorganic & Medicinal Chemistry Letters, 2007, De Lamo Marin, Sandra et. al.
Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.
score: 1.4438248, Antimicrobial agents and chemotherapy, 2003, Koh, Yasuhiro et. al.
1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives
score: 1.4437691, European Journal of Medicinal Chemistry, 2002, Rathelot, Pascal et. al.
Structural bases for the inhibition of aldose reductase by phenolic compounds
score: 1.4436087, Bioorganic & Medicinal Chemistry, 2000, Rastelli, Giulio et. al.
Synthesis of ODNs Containing 4-Methylamino-1,8-naphthalimide as a fluorescence probe in DNA
score: 1.4434912, Bioorganic & Medicinal Chemistry Letters, 2002, Kawai, Kiyohiko et. al.
A novel spirocyclic tropanyl-Δ2-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake
score: 1.4434203, Bioorganic & Medicinal Chemistry, 2012, Dallanoce, Clelia et. al.
A novel spirocyclic tropanyl-Δ2-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake
score: 1.4434203, Bioorganic & Medicinal Chemistry, 2012, Dallanoce, Clelia et. al.
Synthesis and cytotoxicity of new heterocyclic terpenylnaphthoquinones
score: 1.4432795, Bioorganic & Medicinal Chemistry, 2006, Miguel del Corral, José M. et. al.
Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/FcεRI receptor mediated mast cell leukotriene release
score: 1.4431241, Bioorganic & Medicinal Chemistry, 2003, Venkatachalam, T.K; Qazi, S; Samuel, P; Uckun, F.M
Hantzsch pyrrole synthesis on solid support
score: 1.4431188, Bioorganic & Medicinal Chemistry Letters, 1998, Trautwein, Axel W.; Süßmuth, Roderich D.; Jung, Günther
New strategies for the synthesis of A 3 adenosine receptor antagonists
score: 1.4430017, Bioorganic & Medicinal Chemistry, 2003, Baraldi, Pier Giovanni et. al.
GETAWAY descriptors to predicting A 2A adenosine receptors agonists
score: 1.4429368, European Journal of Medicinal Chemistry, 2005, González, M.P.; Terán, C.; Teijeira, M.; González-Moa, M.J.
Convergent solution-phase synthesis of a nucleopeptide using a protected oligonucleotide
score: 1.4425724, Bioorganic & Medicinal Chemistry Letters, 1999, McMinn, Dustin L.; Greenberg, Marc M.
Antimycobacterial activities of novel levofloxacin analogues.
score: 1.4424439, Antimicrobial agents and chemotherapy, 2000, Kawakami, K et. al.
Novel (bisarylmethoxy)butylpiperidine analogues as neurotransmitter transporter inhibitors with activity at dopamine receptor sites
score: 1.4424125, Bioorganic & Medicinal Chemistry, 2002, Choi, Sung-Woon et. al.
Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane
score: 1.4423856, Bioorganic & Medicinal Chemistry Letters, 2007, Ban, Shizuka et. al.
A facile solid phase synthesis of tetramic acid
score: 1.4423362, Bioorganic & Medicinal Chemistry Letters, 2003, Liu, Zhanxiang; Ruan, Xiuxiu; Huang, Xian
Quantitative structure–activity relationship studies of HIV-1 integrase inhibition. 1. GETAWAY descriptors
score: 1.4422871, European Journal of Medicinal Chemistry, 2007, Saíz-Urra, Liane et. al.
Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents
score: 1.4422468, Bioorganic & Medicinal Chemistry Letters, 2006, Patole, Jayendra et. al.
Synthesis of benzofuran based 1,3,5-substituted pyrazole derivatives: As a new class of potent antioxidants and antimicrobials-A novel accost to amend biocompatibility
score: 1.4421951, Bioorganic & Medicinal Chemistry Letters, 2012, Rangaswamy, Javarappa et. al.
Novel estimation of lipophilicity using 13C NMR chemical shifts as molecular descriptor
score: 1.442012, Bioorganic & Medicinal Chemistry Letters, 2005, Khadikar, Padmakar V.; Sharma, Vimukta; Varma, R.G.
Fully flexible docking models of the complex between α7 nicotinic receptor and a potent heptapeptide inhibitor of the β-amyloid peptide binding
score: 1.4419504, Bioorganic & Medicinal Chemistry Letters, 2006, Espinoza-Fonseca, L. Michel; Trujillo-Ferrara, José G.
Inhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation
score: 1.4419115, Bioorganic & Medicinal Chemistry, 2004, Jeong, Tae-Sook et. al.
RGD–cyclam conjugate: Synthesis and potential application for positron emission tomography
score: 1.4418833, Bioorganic & Medicinal Chemistry Letters, 2010, Galibert, Mathieu et. al.
Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: chemical hydrolysis and anti-bacterial activity
score: 1.4418457, Bioorganic & Medicinal Chemistry, 2000, Iley, Jim et. al.
Metalloantimalarials: Synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone
score: 1.4418411, Bioorganic & Medicinal Chemistry Letters, 2006, Gokhale, Nikhil H. et. al.
Activities of dicationic compounds against Trichomonas vaginalis.
score: 1.4418184, Antimicrobial agents and chemotherapy, 2004, Crowell, Andrea L et. al.
Development of novel linkers to conjugate pharmacophores to a carrier antibody
score: 1.4416868, Bioorganic & Medicinal Chemistry Letters, 2012, Palanki, Moorthy S.S. et. al.
‘Click’ synthesis of a triazole-based inhibitor of Met functions in cancer cells
score: 1.4415999, Bioorganic & Medicinal Chemistry Letters, 2012, Colombo, Francesco et. al.
16alpha-bromoepiandrosterone, an antimalarial analogue of the hormone dehydroepiandrosterone, enhances phagocytosis of ring stage parasitized erythrocytes: a novel mechanism for antimalarial activity.
score: 1.4415925, Antimicrobial agents and chemotherapy, 2002, Ayi, Kodjo et. al.
Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture
score: 1.4413156, Bioorganic & Medicinal Chemistry, 2003, Li, Zhuorong et. al.
Novel mechanism for nisin resistance via proteolytic degradation of nisin by the nisin resistance protein NSR.
score: 1.4412839, Antimicrobial agents and chemotherapy, 2009, Sun, Zhizeng et. al.
In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
score: 1.4412428, Antimicrobial agents and chemotherapy, 2008, Shi, Stephanie T et. al.
Design and synthesis of isoxazole and isoxazoline linkage for replacement of nucleotide phosphodiester
score: 1.4412106, Bioorganic & Medicinal Chemistry Letters, 1998, Kim, Su Jeong; Lee, Ju Young; Kim, Byeang Hyean
Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
score: 1.4410995, European Journal of Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
score: 1.4410995, European Journal of Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Estimation of hERG inhibition of drug candidates using multivariate property and pharmacophore SAR
score: 1.4410879, Bioorganic & Medicinal Chemistry, 2007, Johnson, Stephen R. et. al.
Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress.
score: 1.4410504, Antimicrobial agents and chemotherapy, 2004, Koshkin, Aleksey et. al.
Clozapine derived 2,3-dihydro-1 H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing
score: 1.4409876, Bioorganic & Medicinal Chemistry, 2004, Hussenether, Thomas et. al.
Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents
score: 1.4406342, European Journal of Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells
score: 1.4406262, Bioorganic & Medicinal Chemistry, 2006, Wang, Xinyu et. al.
Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides
score: 1.4405507, Bioorganic & Medicinal Chemistry, 2006, Qin, Xinrong et. al.
Selection of a 2-azabicyclo[2.2.2]octane-based α 4β 1 integrin antagonist as an inhaled anti-asthmatic agent
score: 1.4405503, Bioorganic & Medicinal Chemistry, 2006, Lawson, Edward C. et. al.
Synthesis and cytotoxic activity of novel C7-Functionalized spongiane diterpenes
score: 1.4405342, Bioorganic & Medicinal Chemistry, 2003, Arnó, Manuel et. al.
Rationalization of physicochemical characters of oxazolyl thiosemicarbazone analogs towards multi-drug resistant tuberculosis: A QSAR approach
score: 1.4405144, European Journal of Medicinal Chemistry, 2007, Gupta, Revathi A. et. al.
Design and synthesis of DNA-intercalating 9-fluoren-β- O-glycosides as potential IFN-inducers, and antiviral and cytostatic agents
score: 1.4404608, Bioorganic & Medicinal Chemistry, 2004, Alcaro, S et. al.
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3 H)ones as anti-inflammatory and analgesic agents
score: 1.440382, Bioorganic & Medicinal Chemistry, 2001, Schenone, Silvia et. al.
A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.
score: 1.4403263, Antimicrobial agents and chemotherapy, 2004, Olsen, David B et. al.
Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles
score: 1.4403078, Bioorganic & Medicinal Chemistry, 2004, Cottrell, Denise M et. al.
Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-yl] piperazinyl quinolones
score: 1.4401967, European Journal of Medicinal Chemistry, 2003, Foroumadi, Alireza et. al.
Search for the pharmacophore in prazosin for Transport-P
score: 1.4401288, Bioorganic & Medicinal Chemistry, 2005, Zunszain, Patricia A. et. al.
Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities
score: 1.4401005, Bioorganic & Medicinal Chemistry Letters, 2012, Sipos, Attila et. al.
Antimalarial 9-anilinoacridine compounds directed at hematin.
score: 1.4398202, Antimicrobial agents and chemotherapy, 2003, Auparakkitanon, Saranya et. al.
Synthesis of a transition state analogue for the hydrolysis of cocaine: Assistance to phosphonylation of a 3β-hydroxytropane by a neighbouring amide group
score: 1.4395831, Bioorganic & Medicinal Chemistry Letters, 1999, Hagi-Pavli, Eleni P et. al.
Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism
score: 1.4394, Bioorganic & Medicinal Chemistry, 2003, Yoon, Kyoung Jin P et. al.
Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Vα19 NKT cell with α-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit
score: 1.439264, European Journal of Medicinal Chemistry, 2006, Shimamura, Michio et. al.
The first synthesis of glucosylgalactosyl hydroxylysine (Glu-Gal-Hyl) an important biological indicator of collagen turnover
score: 1.4389949, Bioorganic & Medicinal Chemistry Letters, 2004, Allevi, Pietro et. al.
Two novel bioactive glucosinolates from Broccoli (Brassica oleracea L. var. italica) florets
score: 1.4388972, Bioorganic & Medicinal Chemistry Letters, 2012, Survay, Nazneen Shaik et. al.
Selective interaction between tylophorine B and bulged DNA
score: 1.4388555, Bioorganic & Medicinal Chemistry Letters, 2005, Xi, Zhen et. al.
Synthesis of benzo-annulated tryptanthrins and their biological properties
score: 1.4388209, Bioorganic & Medicinal Chemistry, 2012, Liang, Jing Lu et. al.
Molecular characterization of OXA-20, a novel class D beta-lactamase, and its integron from Pseudomonas aeruginosa.
score: 1.4387768, Antimicrobial agents and chemotherapy, 1998, Naas, T; Sougakoff, W; Casetta, A; Nordmann, P
N-(3-Triethoxysilylpropyl)-4-( N′-maleimidylmethyl)cyclohexanamide (TPMC): A heterobifunctional reagent for immobilization of oligonucleotides on glass surface
score: 1.4387548, Bioorganic & Medicinal Chemistry Letters, 2007, Misra, Arvind
Synthesis and antiproliferative activity of triazenoindazoles and triazenopyrazoles: a comparative study
score: 1.4386511, European Journal of Medicinal Chemistry, 2004, Daidone, Giuseppe et. al.
Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography
score: 1.4385465, Bioorganic & Medicinal Chemistry, 2012, Matijssen, Cornelis et. al.
Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography
score: 1.4385465, Bioorganic & Medicinal Chemistry, 2012, Matijssen, Cornelis et. al.
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors
score: 1.4383104, Bioorganic & Medicinal Chemistry, 2006, Beauchard, Anne et. al.
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the μ-opioid receptor and I 2–imidazoline binding sites
score: 1.4381955, Bioorganic & Medicinal Chemistry, 2006, Dardonville, Christophe et. al.
A short synthesis of antimalarial peroxides
score: 1.4381943, Bioorganic & Medicinal Chemistry, 2003, Cointeaux, L et. al.
Synthesis, resolution and anticonvulsant activity of chiral N-1′-ethyl,N-3′-(1-phenylethyl)-(R,S)-2′H,3H,5′H-spiro-(2-benzofuran-1,4′-imidazolidine)-2′,3,5′-trione diastereomers
score: 1.4380261, Bioorganic & Medicinal Chemistry Letters, 2012, Sadarangani, Ishwar R. et. al.
Chiral multinuclear macrocyclic polyamine complexes: Synthesis, characterization and their interaction with plasmid DNA
score: 1.4379305, Bioorganic & Medicinal Chemistry, 2007, Fang, Yu-Guo et. al.
Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation
score: 1.437635, Bioorganic & Medicinal Chemistry, 1997, Mallams, A.K. et. al.
Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues
score: 1.4374615, Bioorganic & Medicinal Chemistry, 2003, Wang, Yuqiang et. al.
Exploration of Cathepsin S Inhibitors Characterized by a Triazole P1-P2 Amide Replacement
score: 1.4374243, Bioorganic & Medicinal Chemistry Letters, 2012, Moss, Neil et. al.
A convenient and efficient protocol for oxidative aromatization of Hantzsch 1,4-dihydropyridines using benzyltriphenylphosphonium peroxymonosulfate under almost neutral reaction conditions
score: 1.4373576, Bioorganic & Medicinal Chemistry Letters, 2007, Adibi, Hadi; Hajipour, Abdol Reza
Green route for the heterocyclization of 2-mercaptobenzimidazole into β-lactum segment derivatives containing –CONH– bridge with benzimidazole: Screening in vitro antimicrobial activity with various microorganisms
score: 1.4373052, Bioorganic & Medicinal Chemistry, 2006, Desai, Krunal G.; Desai, Kishor R.
Effect of polycyclic cage amines on the transmembrane potential of neuronal cells
score: 1.437271, Bioorganic & Medicinal Chemistry, 2006, Grobler, Erika et. al.
Synthesis and cytotoxic activity of benzo[ c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine
score: 1.4371542, Bioorganic & Medicinal Chemistry, 2004, Prado, Soizic et. al.
Effect of hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 on growth and pathogenicity of Sendai/human parainfluenza type 3 chimera virus in mice.
score: 1.4371479, Antimicrobial agents and chemotherapy, 2009, Watanabe, Makiko et. al.
Synthesis, characterization and in vitro antitumour activity of a series of novel platinum(II) complexes bearing Schiff base ligands
score: 1.4371218, European Journal of Medicinal Chemistry, 2012, Proetto, Maria et. al.
Synthesis, characterization and in vitro antitumour activity of a series of novel platinum(II) complexes bearing Schiff base ligands
score: 1.4371218, European Journal of Medicinal Chemistry, 2012, Proetto, Maria et. al.
Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.
score: 1.4370932, Antimicrobial agents and chemotherapy, 2012, Watanabe, Takafumi et. al.
Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist.
score: 1.4370483, Antimicrobial agents and chemotherapy, 2005, Takashima, Katsunori et. al.
Synthesis and antiproliferative activity of [1,2,3,5]tetrazino[5,4- a]indoles, a new class of azolo-tetrazinones
score: 1.4369942, Bioorganic & Medicinal Chemistry, 2005, Barraja, Paola et. al.
5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel.
score: 1.4368928, Antimicrobial agents and chemotherapy, 2003, Locher, Christopher P et. al.
QSAR Studies on Antimalarial Substituted Phenyl Analogues and Their N ω-Oxides
score: 1.436865, Bioorganic & Medicinal Chemistry, 2002, Agrawal, Vijay K.; Sharma, Ruchi; Khadikar, Padmakar V.
Technetium-99m labelled integrated tropane–BAT as a potential dopamine transporter tracer
score: 1.4365268, Bioorganic & Medicinal Chemistry, 2005, Cleynhens, Bernard J. et. al.
Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro
score: 1.4364668, Bioorganic & Medicinal Chemistry, 2012, Schneider, Carolin C. et. al.
Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro
score: 1.4364668, Bioorganic & Medicinal Chemistry, 2012, Schneider, Carolin C. et. al.
Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro
score: 1.4364668, Bioorganic & Medicinal Chemistry, 2012, Schneider, Carolin C. et. al.
Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor
score: 1.4364664, Bioorganic & Medicinal Chemistry, 2010, Chen, Chao-Nan et. al.
Aromatic analogues of DNA minor groove binders—synthesis and biological evaluation
score: 1.4364569, European Journal of Medicinal Chemistry, 2004, Pućkowska, Anna et. al.
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist
score: 1.436391, Bioorganic & Medicinal Chemistry Letters, 2012, Epifano, Francesco et. al.
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist
score: 1.436391, Bioorganic & Medicinal Chemistry Letters, 2012, Epifano, Francesco et. al.
A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes
score: 1.4361201, Bioorganic & Medicinal Chemistry Letters, 2012, Pham, The Hien et. al.
A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes
score: 1.4361201, Bioorganic & Medicinal Chemistry Letters, 2012, Pham, The Hien et. al.
Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps.
score: 1.4360751, Antimicrobial agents and chemotherapy, 2005, Bohnert, Jürgen A; Kern, Winfried V
Resistance to beta-lactamase inhibitor protein does not parallel resistance to clavulanic acid in TEM beta-lactamase mutants.
score: 1.4359028, Antimicrobial agents and chemotherapy, 2002, Schroeder, William A; Locke, Troy R; Jensen, Susan E
New palladium(II) complexes bearing pyrazole-based Schiff base ligands: Synthesis, characterization and cytotoxicity
score: 1.4358215, European Journal of Medicinal Chemistry, 2010, Abu-Surrah, Adnan S. et. al.
Homogeneous gold-catalyzed efficient oxidative dimerization of propargylic acetates
score: 1.4357085, Bioorganic & Medicinal Chemistry Letters, 2009, Cui, Li; Zhang, Guozhu; Zhang, Liming
Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability
score: 1.4354781, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Sungwoon et. al.
Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT 1B receptor
score: 1.4353991, European Journal of Medicinal Chemistry, 2004, Moloney, Gerard P. et. al.
Probing the aglycon binding site of a β-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino- d-mannitol derivatives and their structure–activity relationships as competitive inhibitors
score: 1.4353479, Bioorganic & Medicinal Chemistry, 2004, Wrodnigg, Tanja M. et. al.
Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease
score: 1.4352631, Bioorganic & Medicinal Chemistry Letters, 2009, Chen, Xiaoqiang et. al.
New apratoxins of marine cyanobacterial origin from guam and palau
score: 1.4352496, Bioorganic & Medicinal Chemistry, 2002, Luesch, Hendrik et. al.
Effects of mutations in ribosomal protein L16 on susceptibility and accumulation of evernimicin.
score: 1.4352433, Antimicrobial agents and chemotherapy, 2001, McNicholas, P M et. al.
Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere
score: 1.4351904, Bioorganic & Medicinal Chemistry Letters, 2013, Downey, Jason D. et. al.
Tracermer TM signal generators: An arborescent approach to the incorporation of multiple chemiluminescent labels
score: 1.4351521, Bioorganic & Medicinal Chemistry Letters, 1998, Adamczyk, Maciej et. al.
Iminosugars as glycosyltransferase inhibitors: synthesis of polyhydroxypyrrolidines and their evaluation on chitin synthase activity
score: 1.4350236, European Journal of Medicinal Chemistry, 2005, Gautier-Lefebvre, Isabelle et. al.
Fluorinated phenylcyclopropylamines. Part 4: Effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro-cyclopropylamines
score: 1.4348776, Bioorganic & Medicinal Chemistry, 2005, Ye, Song et. al.
A concise synthesis of the 6- o- and 6′- o-sulfated analogues of the sialyl lewis X tetrasaccharide
score: 1.4348595, Bioorganic & Medicinal Chemistry Letters, 2000, Misra, Anup Kumar; Ding, Yili; Lowe, John B; Hindsgaul, Ole
Targeting integrins: Insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids
score: 1.4345257, Bioorganic & Medicinal Chemistry, 2006, Belvisi, Laura et. al.
Species marker for developing novel and safe pesticides
score: 1.4344367, Bioorganic & Medicinal Chemistry Letters, 2007, Pang, Yuan-Ping
Positively coded photoaffinity label for altering isoelectric points of proteins
score: 1.4342866, Bioorganic & Medicinal Chemistry Letters, 2006, Hashimoto, Makoto; Hatanaka, Yasumaru
Synthesis and characterization of a carboranyl-tetrabenzoporphyrin
score: 1.4342421, Bioorganic & Medicinal Chemistry Letters, 2005, Ongayi, Owendi et. al.
Synthesis of indomethacin analogues for evaluation as modulators of MRP activity
score: 1.4341929, Bioorganic & Medicinal Chemistry, 2001, Maguire, Anita R. et. al.
Design of N-acetyl-6-sulfo-β- d-glucosaminide-based inhibitors of influenza virus sialidase
score: 1.4341472, Bioorganic & Medicinal Chemistry, 2004, Sasaki, Kenji et. al.
Synthesis of 1- O-monoacyl or 12- O-monoacyl, 1-,12- O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity
score: 1.433975, Bioorganic & Medicinal Chemistry, 2006, Aoyagi, Yutaka et. al.
Synthesis and hybridization property of an oligonucleotide containing a 3′-thioformcetal linked pentathymidylate
score: 1.4339567, Bioorganic & Medicinal Chemistry Letters, 1999, Zhang, Jiancun; Shaw, Jared T.; Matteucci, Mark D.
Identification of small molecule inhibitors against SecA of Candidatus Liberibacter asiaticus by structure based design
score: 1.4339016, European Journal of Medicinal Chemistry, 2012, Akula, Nagaraju; Trivedi, Pankaj; Han, Frank Q.; Wang, Nian
Identification of small molecule inhibitors against SecA of Candidatus Liberibacter asiaticus by structure based design
score: 1.4339016, European Journal of Medicinal Chemistry, 2012, Akula, Nagaraju; Trivedi, Pankaj; Han, Frank Q.; Wang, Nian
Structure–activity relationships in nitrothiophenes
score: 1.4336481, Bioorganic & Medicinal Chemistry, 2006, Morley, John O.; Matthews, Thomas P.
Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties
score: 1.433603, Bioorganic & Medicinal Chemistry, 1998, Nadler, Guy et. al.
Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: Cytotoxicity against human leukemia cell lines
score: 1.4333094, European Journal of Medicinal Chemistry, 2010, Reis, Débora C. et. al.
Study on noncovalent complexes of cytotoxic protoberberine alkaloids with double-stranded DNA by using electrospray ionization mass spectrometry
score: 1.4332892, Bioorganic & Medicinal Chemistry Letters, 2004, Chen, Wen-Hua et. al.
Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents
score: 1.4332707, European Journal of Medicinal Chemistry, 2012, Rashid, Mohd; Husain, Asif; Mishra, Ravinesh
Synthesis, crystal structure, DNA-binding and cytotoxicity in vitro of novel cis-Pt(II) and trans-Pd(II) pyridine carboxamide complexes
score: 1.4332283, Bioorganic & Medicinal Chemistry Letters, 2010, Shi, Chun-Yue et. al.
Design and synthesis of complementing ligands for mutant thyroid hormone receptor TRβ(R320H): a tailor-made approach toward the treatment of resistance to thyroid hormone
score: 1.4331384, Bioorganic & Medicinal Chemistry, 2005, Hashimoto, Atsushi et. al.
Topological approach to quantifying molecular lipophilicity of heterogeneous set of organic compounds
score: 1.433086, Bioorganic & Medicinal Chemistry, 2003, Agrawal, Vijay K.; Bano, Shahnaz; Khadikar, Padmakar V.
5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4
score: 1.4330698, European Journal of Medicinal Chemistry, 2012, Vitale, Gabriella et. al.
5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4
score: 1.4330698, European Journal of Medicinal Chemistry, 2012, Vitale, Gabriella et. al.
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe
score: 1.4329797, Bioorganic & Medicinal Chemistry Letters, 2012, Delpire, Eric et. al.
Convenient synthesis of novel 4-substitutedamino-5-trifluoromethyl–2,7-disubstituted pyrido[2,3- d] pyrimidines and their antibacterial activity
score: 1.4329289, European Journal of Medicinal Chemistry, 2006, Ravi Kanth, S. et. al.
An unnatural hydrophobic base, 4-propynylpyrrole-2-carbaldehyde, as an efficient pairing partner of 9-methylimidazo[(4,5)- b]pyridine
score: 1.432491, Bioorganic & Medicinal Chemistry Letters, 2003, Mitsui, Tsuneo et. al.
(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H 3 receptors
score: 1.4324516, Bioorganic & Medicinal Chemistry, 2000, Sasse, Astrid et. al.
New highly active taxoids from 9β-Dihydrobaccatin-9,10-acetals. Part 4
score: 1.4324153, Bioorganic & Medicinal Chemistry, 2003, Takeda, Yasuyuki et. al.
Preparation and properties of 2′,5′-linked oligonucleotide analogues containing 3′- O,4′- C-methyleneribonucleosides
score: 1.4323861, Bioorganic & Medicinal Chemistry Letters, 1999, Obika, Satoshi et. al.
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2’-deoxyadenosine 5’-triphosphate as inhibitors of HIV-1 reverse transcriptase
score: 1.432311, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Jiae et. al.
α- and β-Homogalactonojirimycins (α- and β-Homogalactostatins)
score: 1.4322957, Bioorganic & Medicinal Chemistry, 2001, Martin, Olivier R. et. al.
Kinetic resolution of aliphatic acyclic β-hydroxyketones by recombinant whole-cell Baeyer–Villiger monooxygenases—Formation of enantiocomplementary regioisomeric esters
score: 1.4322862, Bioorganic & Medicinal Chemistry Letters, 2009, Rehdorf, Jessica et. al.
A novel d-glucose derivative radiolabeled with technetium-99m: Synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor
score: 1.4321659, Bioorganic & Medicinal Chemistry Letters, 2010, de Barros, André Luís Branco et. al.
Synthesis and biological activity of new 2-amino-8-chloro-5,5-dioxo[1,2,4]triazolo[2,3- b][1,4,2]benzodithiazines
score: 1.4321442, European Journal of Medicinal Chemistry, 2006, Pomarnacka, Elżbieta et. al.
Donepezil–tacrine hybrid related derivatives as new dual binding site inhibitors of AChE
score: 1.4320114, Bioorganic & Medicinal Chemistry, 2005, Alonso, D. et. al.
A simple and efficient approach to the synthesis of 4 H-furo[3,4- b]pyrans via a three-component reaction of isocyanides
score: 1.431995, Bioorganic & Medicinal Chemistry Letters, 2008, Shaabani, Ahmad et. al.
Quantitative structure–activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents
score: 1.4319367, Bioorganic & Medicinal Chemistry, 1998, Kim, Jung Sun et. al.
Synthesis and evaluation of homofarnesoyl-substituted CAAX-peptidomimetics as farnesyltransferase inhibitors and antiproliferative agents
score: 1.4317768, Bioorganic & Medicinal Chemistry, 1999, Schlitzer, Martin; Sattler, Isabel; Dahse, Hans-Martin
Overcoming acquired resistance to kinase inhibition: The cases of EGFR, ALK and BRAF
score: 1.4317719, Bioorganic & Medicinal Chemistry Letters, 2013, Giroux, Simon
Use of the PI Index in Predicting Toxicity of Nitrobenzene Derivatives
score: 1.4316618, Bioorganic & Medicinal Chemistry, 2002, Khadikar, Padmakar V. et. al.
Insecticidal lead identification by screening benzopyrano[4,3- c] pyrazol-3(2 H)-ones library constructed from multiple-parallel synthesis under microwave irradiation
score: 1.4315709, Bioorganic & Medicinal Chemistry, 2006, Zhou, Zhong-Zheng; Yang, Guang-Fu
Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents
score: 1.4313141, Bioorganic & Medicinal Chemistry, 2004, Ismail, Mohamed A. et. al.
TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors.
score: 1.4311179, Antimicrobial agents and chemotherapy, 2011, Dierynck, Inge et. al.
Synthesis and structure–Activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents
score: 1.4311123, Bioorganic & Medicinal Chemistry, 2003, Neogi, Partha et. al.
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
score: 1.4309622, Bioorganic & Medicinal Chemistry, 2012, Cloete, Theunis T. et. al.
Enhancement of DNA cleavage activity of an unnatural ferrocene-amino acid conjugate
score: 1.4308991, Bioorganic & Medicinal Chemistry Letters, 2009, Higgins, Pamela J.; Gellett, Amanda M.
Synthesis of β-ionone derived chalcones as potent antimicrobial agents
score: 1.4304441, Bioorganic & Medicinal Chemistry Letters, 2012, Sharma, Vishal et. al.
X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist
score: 1.4303661, Bioorganic & Medicinal Chemistry Letters, 1998, Quéré, Luc et. al.
Synthesis and biological evaluation of novel T-type Ca 2+ channel blockers
score: 1.4302475, Bioorganic & Medicinal Chemistry, 2004, Jung, Hee Kyung et. al.
Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives
score: 1.4301483, Bioorganic & Medicinal Chemistry Letters, 2012, Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives
score: 1.4301483, Bioorganic & Medicinal Chemistry Letters, 2012, Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives
score: 1.4301483, Bioorganic & Medicinal Chemistry Letters, 2012, Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Synthesis and biological activity of 1β-methyl-2-[5-(2- N-substituted aminoethylcarbamoyl)pyrrolidin-3-ylthio]carbapenem derivatives
score: 1.4301191, European Journal of Medicinal Chemistry, 2003, Oh, Chang-Hyun; Lee, Su-Chul; Cho, Jung-Hyuck
An efficient conversion of 5-nitroisatin into 5-nitroindole derivative
score: 1.4301127, Bioorganic & Medicinal Chemistry Letters, 2001, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-Ichi
The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.
score: 1.4300727, Antimicrobial agents and chemotherapy, 2012, Skinner-Adams, Tina S et. al.
Development and Evaluation of Multifunctional Agents for Potential Treatment of Alzheimer’s Disease: Application to a Pyrimidine-2,4-Diamine Template
score: 1.4300157, Bioorganic & Medicinal Chemistry Letters, 2012, Mohamed, Tarek et. al.
Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters.
score: 1.4298675, Antimicrobial agents and chemotherapy, 1998, Srinivas, R V; Middlemas, D; Flynn, P; Fridland, A
(Z)-1,4-Diamino-2-butene as a vector of boron, fluorine, or iodine for cancer therapy and imaging: synthesis and biological evaluation
score: 1.4298302, Bioorganic & Medicinal Chemistry, 2002, Martin, Bénédicte et. al.
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation
score: 1.4297981, Bioorganic & Medicinal Chemistry Letters, 2012, Banerjee, Abhisek et. al.
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation
score: 1.4297981, Bioorganic & Medicinal Chemistry Letters, 2012, Banerjee, Abhisek et. al.
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation
score: 1.4297981, Bioorganic & Medicinal Chemistry Letters, 2012, Banerjee, Abhisek et. al.
Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl] fluoroquinolonic derivatives
score: 1.4297891, European Journal of Medicinal Chemistry, 2006, Talath, S.; Gadad, A.K.
Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine mollusk
score: 1.42978, Bioorganic & Medicinal Chemistry Letters, 2012, Umehara, Masahiro et. al.
Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine mollusk
score: 1.42978, Bioorganic & Medicinal Chemistry Letters, 2012, Umehara, Masahiro et. al.
Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine mollusk
score: 1.42978, Bioorganic & Medicinal Chemistry Letters, 2012, Umehara, Masahiro et. al.
Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2- c]pyrazol-based Ligands for CB 1and CB 2 Cannabinoid Receptors
score: 1.4297084, Bioorganic & Medicinal Chemistry, 2003, Mussinu, Jean-Mario et. al.
Conformational analysis of trimeric maleimide substituted 1,5,9-triazacyclododecane HIV fusion scaffolds
score: 1.4296556, Bioorganic & Medicinal Chemistry, 2009, Remmert, Sarah; Hollis, Heather; Parish, Carol A.
The Antibacterial Activity of 4,4’-Bipyridinium Amphiphiles with Conventional, Bicephalic and Gemini Architectures
score: 1.429635, Bioorganic & Medicinal Chemistry Letters, 2012, Grenier, Melissa C. et. al.
Synthesis and in vitro microbiological evaluation of imidazo(4,5-b)pyridinylethoxypiperidones
score: 1.429606, European Journal of Medicinal Chemistry, 2006, Aridoss, G.; Balasubramanian, S.; Parthiban, P.; Kabilan, S.
Synthesis, σ1, σ2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes
score: 1.4294821, Bioorganic & Medicinal Chemistry, 2012, Riganas, Stefanos et. al.
Uronosyl phosphonate-based sialidase inhibitor synthesis and conformational analysis
score: 1.4294713, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Beenu; Thomson, Robin J.; von Itzstein, Mark
Uronosyl phosphonate-based sialidase inhibitor synthesis and conformational analysis
score: 1.4294713, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Beenu; Thomson, Robin J.; von Itzstein, Mark
Uronosyl phosphonate-based sialidase inhibitor synthesis and conformational analysis
score: 1.4294713, Bioorganic & Medicinal Chemistry Letters, 2012, Bhatt, Beenu; Thomson, Robin J.; von Itzstein, Mark
The study on the interaction between seryl-histidine dipeptide and proteins by circular dichroism and molecular modeling
score: 1.4294432, Bioorganic & Medicinal Chemistry, 2005, Zeng, Qing; Yin, Qiang; Zhao, Yufen
Synthesis and antiamoebic activity of new 1- N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives and their Pd(II) complexes
score: 1.4292165, European Journal of Medicinal Chemistry, 2006, Budakoti, Asha; Abid, Mohammad; Azam, Amir
Synthesis and antiproliferative activity of novel sugiol β-amino alcohol analogs
score: 1.4291065, European Journal of Medicinal Chemistry, 2006, Córdova, I. et. al.
Syntheses of 3-carbomethoxy-4-(aryl)piperidines and In vitro and In vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter
score: 1.428945, Bioorganic & Medicinal Chemistry, 2003, Feng, Xianqi et. al.
Synthesis and stereochemistry of the terminal spiroketal domain of the phosphatase inhibitor dinophysistoxin-2
score: 1.4289388, Bioorganic & Medicinal Chemistry Letters, 2008, Forsyth, Craig J.; Wang, Ce
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor
score: 1.4288299, Bioorganic & Medicinal Chemistry Letters, 2012, Salovich, James M. et. al.
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor
score: 1.4288299, Bioorganic & Medicinal Chemistry Letters, 2012, Salovich, James M. et. al.
Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates
score: 1.4287887, Bioorganic & Medicinal Chemistry, 2009, LaBeaume, Paul et. al.
Characterization of TAE684 as a potent LRRK2 kinase inhibitor
score: 1.4285669, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Jinwei et. al.
2,5-Bis-(2-hydroxybenzoylamino)pentanoic acid, a salicylic acid-metabolite isolated from chicken: characterization and independent synthesis
score: 1.4285, Bioorganic & Medicinal Chemistry Letters, 2003, Hillaert, Ulrik et. al.
Deconstructing 14-phenylpropyloxymetopon: Minimal requirements for binding to mu opioid receptors
score: 1.4284293, Bioorganic & Medicinal Chemistry, 2012, Stavitskaya, Lidiya et. al.
Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells
score: 1.4283109, Bioorganic & Medicinal Chemistry Letters, 2009, Suhara, Yoshitomo; Wada, Akimori; Okano, Toshio
Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor
score: 1.4282527, Bioorganic & Medicinal Chemistry Letters, 2010, Kakuta, Hiroki et. al.
Recent developments in the field of A 2A and A 3 adenosine receptor antagonists
score: 1.4282186, European Journal of Medicinal Chemistry, 2003, Baraldi, Pier Giovanni et. al.
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents
score: 1.4282172, Bioorganic & Medicinal Chemistry, 2004, Bekhit, Adnan A.; Abdel-Aziem, Tarek
Diaryl ester prodrugs of fR900098 with improved in vivo antimalarial activity
score: 1.4281028, Bioorganic & Medicinal Chemistry Letters, 2001, Reichenberg, Armin et. al.
Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation
score: 1.4278783, Bioorganic & Medicinal Chemistry Letters, 2012, Volkova, Maria S. et. al.
Synthesis and antimycobacterial activity of 3,5-disubstituted thiadiazine thiones
score: 1.4278727, Bioorganic & Medicinal Chemistry, 2003, Katiyar, D. et. al.
Role of the C8gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity
score: 1.4278254, Bioorganic & Medicinal Chemistry Letters, 2012, Keck, Gary E. et. al.
Role of the C8gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity
score: 1.4278254, Bioorganic & Medicinal Chemistry Letters, 2012, Keck, Gary E. et. al.
Role of the C8gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity
score: 1.4278254, Bioorganic & Medicinal Chemistry Letters, 2012, Keck, Gary E. et. al.
Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors
score: 1.4276912, European Journal of Medicinal Chemistry, 2012, N'gompaza-Diarra, Joannah et. al.
Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-κB and Akt signalling
score: 1.4273831, European Journal of Medicinal Chemistry, 2012, Zuo, Yinglin et. al.
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones
score: 1.4273551, European Journal of Medicinal Chemistry, 2012, Point, Vanessa et. al.
Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities
score: 1.427346, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Ki Hyun et. al.
Synthesis and antitumor activity of duocarmycin derivatives
score: 1.4273301, Bioorganic & Medicinal Chemistry, 2000, Amishiro, Nobuyoshi et. al.
Solvent free microwave synthesis and evaluation of antimicrobial activity of pyrimido[4,5- b]- and pyrazolo[3,4- b]quinolines
score: 1.4273203, Bioorganic & Medicinal Chemistry, 2006, Selvi, Senniappan Thamarai et. al.
Synthesis and evaluation of fluorine-substituted 1 H-pyrrolo[2,3- b]pyridine derivatives for dopamine D 4 receptor imaging
score: 1.4272941, Bioorganic & Medicinal Chemistry, 2004, Oh, Seung-Jun et. al.
Triterpenoids. Part 21: Oleanolic acid azaderivatives as percutaneous transport promoters
score: 1.4268804, Bioorganic & Medicinal Chemistry Letters, 2004, Zaprutko, Lucjusz et. al.
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
score: 1.4268251, Bioorganic & Medicinal Chemistry, 2012, Ohashi, Tomohiro et. al.
Glucose-specific poly(allylamine) hydrogels—A reassessment
score: 1.4267898, Bioorganic & Medicinal Chemistry Letters, 2007, Fazal, Furqan M.; Hansen, David E.
Antibody against a novel, myriocin (ISP-I)-Based immunosuppressant, FTY720
score: 1.4267396, Bioorganic & Medicinal Chemistry Letters, 2000, Fujita, Tetsuro et. al.
2″-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons
score: 1.4266511, Bioorganic & Medicinal Chemistry, 2000, Rangarajan, Meera et. al.
Chemical modification of β-glucocerebrosidase inhibitor N-octyl-β-valienamine: synthesis and biological evaluation of N-alkanoyl and N-alkyl derivatives
score: 1.4263143, Bioorganic & Medicinal Chemistry, 1998, Ogawa, Seiichiro et. al.
A neural network based classification scheme for cytotoxicity predictions:Validation on 30,000 compounds
score: 1.4263093, Bioorganic & Medicinal Chemistry Letters, 2006, Molnár, László et. al.
Kibdelomycin A, A Congener of Kibdelomycin, Derivatives and Their Antibacterial Activities
score: 1.4262224, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Sheo B. et. al.
Prevention of infection due to Pneumocystis carinii.
score: 1.426152, Antimicrobial agents and chemotherapy, 1998, Fishman, J A
Triterpenoid saponins from Xanthoceras sorbifolia Bunge and their inhibitory activity on human cancer cell lines
score: 1.4261076, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Lili et. al.
Antimicrobial effects of novel siderophores linked to β-lactam antibiotics
score: 1.426082, Bioorganic & Medicinal Chemistry, 2000, Kline, T et. al.
Antileishmanial activities of several classes of aromatic dications.
score: 1.4259229, Antimicrobial agents and chemotherapy, 2002, Brendle, James J et. al.
Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity
score: 1.4258281, Bioorganic & Medicinal Chemistry, 2005, Dodou, Kalliopi et. al.
The hydrogen peroxide induced enhancement of DNA cleavage in the ambient light photolysis of CpFe(CO) 2Ph: A potential strategy for targeting cancer cells
score: 1.4257828, Bioorganic & Medicinal Chemistry Letters, 2005, Mohler, Debra L.; Shell, Thomas A.
2,4,6-Trisubstituted pyrimidine derivatives as pregnancy interceptive agents
score: 1.4257506, Bioorganic & Medicinal Chemistry, 2005, Agarwal, Anu et. al.
Understanding the antifungal activity of terbinafine analogues using quantitative structure–activity relationship (qsar) models
score: 1.4254903, Bioorganic & Medicinal Chemistry, 2000, Gokhale, Vijay M; Kulkarni, Vithal M
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity.
score: 1.4254749, Antimicrobial agents and chemotherapy, 2010, Scudiero, Olga et. al.
The synthesis and biological evaluation of novel Danshensu–cysteine analog conjugates as cardiovascular-protective agents
score: 1.4254382, European Journal of Medicinal Chemistry, 2012, Jia, Yaoling et. al.
Chemical modulators working at pharmacological interface of target proteins
score: 1.4254346, Bioorganic & Medicinal Chemistry, 2012, Jeon, Young Ho; Lee, Jin Young; Kim, Sunghoon
In vitro growth inhibition of human cancer cells by novel honokiol analogs
score: 1.425345, Bioorganic & Medicinal Chemistry, 2012, Lin, Jyh Ming et. al.
Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones
score: 1.4252227, Bioorganic & Medicinal Chemistry, 2006, Ullah Mughal, Ehsan et. al.
Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen
score: 1.4251469, Bioorganic & Medicinal Chemistry Letters, 2004, Vichier-Guerre, Sophie et. al.
Tryptanthrin derivatives asToxoplasma gondiiinhibitors—structure–activity-relationship of the 6-position
score: 1.4251271, Bioorganic & Medicinal Chemistry Letters, 2013, Krivogorsky, Bogdana et. al.
Synthesis of 2-deoxy-2-fluoro-phosphatidylinositol-4,5-bisphosphate and analogues: Probes and modulators of the mammalian PI-PLCS
score: 1.4250724, Bioorganic & Medicinal Chemistry Letters, 1998, Aneja, Sarla G.; Ivanova, Pavlina T.; Aneja, Rajindra
Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties
score: 1.4250524, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties
score: 1.4250524, Bioorganic & Medicinal Chemistry Letters, 2012, Keche, Ashish P. et. al.
Catalytic antibodies: hapten design strategies and screening methods
score: 1.4250188, Bioorganic & Medicinal Chemistry, 2004, Xu, Yang; Yamamoto, Noboru; Janda, Kim D.
Novel antiviral benzofuran-transition metal complexes
score: 1.4249741, European Journal of Medicinal Chemistry, 2010, Galal, Shadia A. et. al.
Novel antiviral benzofuran-transition metal complexes
score: 1.4249741, European Journal of Medicinal Chemistry, 2010, Galal, Shadia A. et. al.
Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity
score: 1.4249173, Bioorganic & Medicinal Chemistry, 2003, Bergemann, Silke et. al.
TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans.
score: 1.4247326, Antimicrobial agents and chemotherapy, 2005, Baba, Masanori et. al.
Selection of a DNA aptamer that binds 8-OHdG using GMP-agarose
score: 1.4245706, Bioorganic & Medicinal Chemistry Letters, 2009, Miyachi, Yusuke et. al.
Novel robust hepatitis C virus mouse efficacy model.
score: 1.4245617, Antimicrobial agents and chemotherapy, 2006, Zhu, Qing et. al.
Tigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii
score: 1.4243367, Bioorganic & Medicinal Chemistry Letters, 2012, Pei, Yi-Hua et. al.
Synthesis and biological applications of two novel fluorescent proteins-labeling probes
score: 1.424286, Bioorganic & Medicinal Chemistry Letters, 2009, Wu, Xiang-long et. al.
Hole Filling and Library Optimization: Application to Commercially Available Fragment Libraries
score: 1.424189, Bioorganic & Medicinal Chemistry, 2012, An, Yuling; Sherman, Woody; Dixon, Steven L.
Iodine-catalyzed condensation of isatin with indoles: A facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity
score: 1.4241646, Bioorganic & Medicinal Chemistry Letters, 2012, Subba Reddy, B.V. et. al.
New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production
score: 1.4241625, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Jing et. al.
Structure–activity relationships of xanthene carboxamides, novel CCR1 receptor antagonists
score: 1.4241605, Bioorganic & Medicinal Chemistry, 2003, Naya, Akira et. al.
Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes
score: 1.4241214, Bioorganic & Medicinal Chemistry, 2006, Gu, Keli et. al.
Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages
score: 1.4240717, Bioorganic & Medicinal Chemistry, 2005, Česnek, Michal et. al.
Transport of the highly charged myo-inositol hexakisphosphate molecule across the red blood cell membrane: a phase transfer and biological study
score: 1.4239249, Bioorganic & Medicinal Chemistry, 2002, Vincent, Stéphane P et. al.
Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors
score: 1.4238101, European Journal of Medicinal Chemistry, 2012, Hasabelnaby, Sherifa et. al.
Synthesis and anti-HIV-1 activity of 4-[4-(4,6-bisphenylamino- [1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenylazo]-5-hydroxynaphthalene-2,7-disulfonic acid and its derivatives
score: 1.4237646, Bioorganic & Medicinal Chemistry, 2004, Naicker, Kannan P et. al.
Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.
score: 1.423762, Antimicrobial agents and chemotherapy, 2011, Guo, Haitao et. al.
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold
score: 1.4236053, Bioorganic & Medicinal Chemistry Letters, 2005, Yan, Liang Z. et. al.
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C6 position
score: 1.4235131, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Sun Ea; Pflum, Mary Kay H.
Pharmacophoric features and Ca 2+ ion holding capacity of verapamil
score: 1.4234988, Bioorganic & Medicinal Chemistry Letters, 2005, Awasthi, Anamika; Yadav, Arpita
New orally active enkephalinase inhibitors: their synthesis, biological activity, and analgesic properties
score: 1.4234489, Bioorganic & Medicinal Chemistry, 1998, Senokuchi, Kazuhiko et. al.
Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone
score: 1.4234346, European Journal of Medicinal Chemistry, 2012, Nithinchandra, ; Kalluraya, B.; Aamir, S.; Shabaraya, A.R.
Identification, characterization, and recombinant expression of epidermicin NI01, a novel unmodified bacteriocin produced by Staphylococcus epidermidis that displays potent activity against Staphylococci.
score: 1.4233518, Antimicrobial agents and chemotherapy, 2012, Sandiford, Stephanie; Upton, Mathew
A short synthesis of troglitazone: An antidiabetic drug for treating insulin resistance
score: 1.4233013, Bioorganic & Medicinal Chemistry Letters, 1999, Cossy, Janine et. al.
Effect of silver content on the structure and antibacterial activity of silver-doped phosphate-based glasses.
score: 1.4232573, Antimicrobial agents and chemotherapy, 2007, Valappil, Sabeel P et. al.
1,2,4-Triazolo mercapto and aminonitriles as potent antifungal agents
score: 1.4231088, Bioorganic & Medicinal Chemistry Letters, 2003, Collin, Xavier; Sauleau, Armelle; Coulon, Joël
Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance
score: 1.4229472, Bioorganic & Medicinal Chemistry, 2000, Rastelli, Giulio et. al.
Design, synthesis, biological evaluation and molecular modeling of novel 1,3,4-oxadiazole derivatives based on Vanillic acid as potential immunosuppressive agents
score: 1.4228648, Bioorganic & Medicinal Chemistry, 2012, Tang, Jian-Feng et. al.
Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups
score: 1.4228069, Bioorganic & Medicinal Chemistry Letters, 2005, Wels, Bas et. al.
Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase fromCryptosporidium parvum
score: 1.4227655, Bioorganic & Medicinal Chemistry Letters, 2013, Johnson, Corey R. et. al.
Correlation of LUMO localization with the α-amylase inhibition constant in a Tendamistat-based series of linear and cyclic peptides
score: 1.4225292, Bioorganic & Medicinal Chemistry, 2005, Heyl, Deborah L. et. al.
Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans
score: 1.4222573, Bioorganic & Medicinal Chemistry, 2005, Miert, Sabine Van et. al.
Probing the physicochemical and structural requirements for glycogen synthase kinase-3α inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides
score: 1.422201, Bioorganic & Medicinal Chemistry, 2006, Sivaprakasam, Prasanna; Xie, Aihua; Doerksen, Robert J.
Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters
score: 1.4219819, Bioorganic & Medicinal Chemistry, 2004, Sandham, David A. et. al.
Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole
score: 1.421894, Bioorganic & Medicinal Chemistry, 2006, Chackal-Catoen, Sarah et. al.
Synthesis and biological activities of three sulfated sialyl Le x ganglioside analogues for clarifying the real carbohydrate ligand structure of L-selectin
score: 1.4217676, Bioorganic & Medicinal Chemistry, 1996, Komba, Shiro et. al.
N-Methylthio β-lactam antibacterials: Effects of the C 3/C 4 ring substituents on anti-MRSA activity
score: 1.4210395, Bioorganic & Medicinal Chemistry, 2005, Turos, Edward et. al.
Identification of carbon-centred radicals derived from linalyl hydroperoxide, a strong skin sensitizer: a possible route for protein modifications
score: 1.420857, Bioorganic & Medicinal Chemistry, 2005, Bezard, Michael et. al.
Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases
score: 1.4205275, European Journal of Medicinal Chemistry, 2008, Bagihalli, Gangadhar B. et. al.
Hydroxyl radicals scavenging activity of N-substituted chitosan and quaternized chitosan
score: 1.4204465, Bioorganic & Medicinal Chemistry Letters, 2006, Guo, Zhanyong et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity
score: 1.4203386, Bioorganic & Medicinal Chemistry, 2012, Li, Xi et. al.
Azabenzthiazole Inhibitors of Leukotriene A4 Hydrolase
score: 1.4202925, Bioorganic & Medicinal Chemistry Letters, 2012, Tanis, Virginia M. et. al.
Synthesis and in vivo evaluation of [ 11C]SN003 as a PET ligand for CRF 1 receptors
score: 1.4199369, Bioorganic & Medicinal Chemistry, 2006, Kumar, J.S. Dileep et. al.
Understanding the unique mechanism of l-FMAU (Clevudine) against hepatitis B virus: molecular dynamics studies
score: 1.4198795, Bioorganic & Medicinal Chemistry Letters, 2002, Chong, Youhoon; Chu, Chung K
QSAR of the inhibition of angiogenesis by TNP-470 and ovalicin analogues: another example of an allosteric interaction
score: 1.4198402, Bioorganic & Medicinal Chemistry, 2001, Mekapati, Suresh Babu; Hansch, Corwin
Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids
score: 1.4197754, Bioorganic & Medicinal Chemistry Letters, 2012, He, Yong et. al.
Synthesis of α-helix mimetics with four side-chains
score: 1.4196928, Bioorganic & Medicinal Chemistry Letters, 2008, Restorp, Per; Rebek, Julius
Study on anti-proliferative effect of benzoxathiole derivatives through inactivation of NF-κB in human cancer cells
score: 1.4195564, Bioorganic & Medicinal Chemistry Letters, 2012, Venkateswararao, Eeda et. al.
Study on anti-proliferative effect of benzoxathiole derivatives through inactivation of NF-κB in human cancer cells
score: 1.4195564, Bioorganic & Medicinal Chemistry Letters, 2012, Venkateswararao, Eeda et. al.
Synthesis of 2,6-Dioxo-(1 H,3 H)-9- N-ribitylpurine and 2,6-Dioxo-(1 H,3 H)-8-aza-9- N-ribitylpurine as inhibitors of lumazine synthase and riboflavin synthase
score: 1.4195135, Bioorganic & Medicinal Chemistry, 1998, Cushman, Mark et. al.
Activity of a novel cyclic lipopeptide, CB-183,315, against resistant Clostridium difficile and other Gram-positive aerobic and anaerobic intestinal pathogens.
score: 1.4192603, Antimicrobial agents and chemotherapy, 2012, Snydman, D R; Jacobus, N V; McDermott, L A
Stereospecific deuteration of α-furanosyl azomycin nucleosides: A model reaction for tritium radiolabeling
score: 1.4192396, Bioorganic & Medicinal Chemistry Letters, 2008, Kumar, Piyush et. al.
Synthesis and biological evaluation of a folate-targeted rhaponticin conjugate
score: 1.4191159, Bioorganic & Medicinal Chemistry, 2013, Liang, Xuhua et. al.
Synthesis and DNA binding properties of dioxime–peptide nucleic acids
score: 1.419004, Bioorganic & Medicinal Chemistry Letters, 2004, Mokhir, Andriy et. al.
Synthesis and photocytotoxic activity of new α-methylene-γ-butyrolactone-psoralen heterodimers
score: 1.4189265, Bioorganic & Medicinal Chemistry, 2004, Ropp, Sandrine et. al.
Synthesis and biology of new thyrotropin-Releasing hormone (TRH) analogues
score: 1.4188883, Bioorganic & Medicinal Chemistry, 2002, Jain, Rahul et. al.
Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action
score: 1.4186394, Bioorganic & Medicinal Chemistry Letters, 1999, Player, Mark R.; Torrence, Paul F.
DNA triplex structures are stabilized by the incorporation of 3′- endo blocked pyrimidine nucleosides in the hoogsteen strand
score: 1.418579, Bioorganic & Medicinal Chemistry Letters, 2000, Savy, Pascal et. al.
Antiprotozoal activities of symmetrical bishydroxamic acids
score: 1.4185699, Bioorganic & Medicinal Chemistry, 2003, Hua, Duy H et. al.
Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity
score: 1.4184817, European Journal of Medicinal Chemistry, 2012, Cui, Yanli et. al.
Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity
score: 1.4184817, European Journal of Medicinal Chemistry, 2012, Cui, Yanli et. al.
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation
score: 1.4184379, Bioorganic & Medicinal Chemistry, 2012, Parmenopoulou, Vanessa et. al.
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation
score: 1.4184379, Bioorganic & Medicinal Chemistry, 2012, Parmenopoulou, Vanessa et. al.
Evaluation of Pharmacokinetic/Pharmacodynamic Relationships of PD-0162819, a Biotin Carboxylase Inhibitor Representing a New Class of Antibacterial Compounds, Using In Vitro Infection Models.
score: 1.4183842, Antimicrobial agents and chemotherapy, 2012, Ogden, Adam et. al.
Discovery of Potent Antimicrobial Peptide Analogs of Ixosin-B
score: 1.4183064, Bioorganic & Medicinal Chemistry Letters, 2012, Lung, Feng-Di T. et. al.
Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity
score: 1.418151, Bioorganic & Medicinal Chemistry, 2005, Ahmed, Hanaa H. et. al.
Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d]thiazole derivatives
score: 1.4180319, European Journal of Medicinal Chemistry, 2012, Cohen, Anita et. al.
The Importance of the 4′-Hydroxyl Hydrogen for the Anti-trypanosomal and Antiviral Properties of (+)-5′-Noraristeromycin and Two 7-Deaza Analogues
score: 1.4179421, Bioorganic & Medicinal Chemistry, 1998, Seley, Katherine L. et. al.
Some new 2,3,6-trisubstituted quinazolinones as potent anti-inflammatory, analgesic and COX-II inhibitors
score: 1.4179142, Bioorganic & Medicinal Chemistry, 2003, Kumar, Ashok et. al.
Conversion of indanone oximes into isocarbostyrils
score: 1.4178898, Bioorganic & Medicinal Chemistry Letters, 2007, Torisawa, Yasuhiro; Aki, Shinji; Minamikawa, Jun-ichi
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds
score: 1.4178414, European Journal of Medicinal Chemistry, 2006, Das, Umashankar et. al.
Substituted oxygenated heterocycles and thio-analogues: synthesis and biological evaluation as melatonin ligands
score: 1.4178318, Bioorganic & Medicinal Chemistry, 2000, Charton, Isabelle et. al.
Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives
score: 1.4177758, BMC Chemical Biology, 2012, Sadashiva, Maralinganadoddi Panchegowda et. al.
Biologically active phenols from Saussurea medusa
score: 1.4177524, Bioorganic & Medicinal Chemistry, 2003, Fan, Cheng-Qi; Yue, Jian-Min
Design, synthesis and biological activity of amidinobicyclic compounds (derivatives of DX-9065a) as factor Xa inhibitors: SAR study of S1 and aryl binding sites
score: 1.4177339, Bioorganic & Medicinal Chemistry, 2004, Komoriya, Satoshi et. al.
Reassessing the melatonin pharmacophore—Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue
score: 1.4176149, Bioorganic & Medicinal Chemistry, 2006, Rivara, Silvia et. al.
Triple Helical Stabilities of Guest–Host Collagen Mimetic Structures
score: 1.4175448, Bioorganic & Medicinal Chemistry, 1999, Kwak, Juliann et. al.
Explaining cyclodextrin–mycotoxin interactions using a ‘natural’ force field
score: 1.417491, Bioorganic & Medicinal Chemistry, 2007, Amadasi, Alessio et. al.
QSAR investigation of NaV1.7 active compounds using the SVM/Signature approach and the Bioclipse Modeling platform
score: 1.4174091, Bioorganic & Medicinal Chemistry Letters, 2013, Norinder, Ulf; Ek, Maria E.
Heterocondensed quinazolones: synthesis and protein-tyrosine kinase inhibitory activity of 3,4-dihydro-1 H,6 H-[1,4]oxazino-[3,4- b]quinazolin-6-one derivatives
score: 1.4172747, Bioorganic & Medicinal Chemistry, 1996, Ôrfi, Lászlo et. al.
Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase
score: 1.4171169, Bioorganic & Medicinal Chemistry, 2012, Yang, Yu-Shun et. al.
Synthesis and antibacterial activity of conjugates between norfloxacin and analogues of the siderophore vanchrobactin
score: 1.4170784, Bioorganic & Medicinal Chemistry, 2013, Souto, Alba et. al.
Discovery of novel tricyclic compounds as squalene synthase inhibitors
score: 1.417014, Bioorganic & Medicinal Chemistry, 2012, Ichikawa, Masanori et. al.
Discovery of novel tricyclic compounds as squalene synthase inhibitors
score: 1.417014, Bioorganic & Medicinal Chemistry, 2012, Ichikawa, Masanori et. al.
Discovery of novel tricyclic compounds as squalene synthase inhibitors
score: 1.417014, Bioorganic & Medicinal Chemistry, 2012, Ichikawa, Masanori et. al.
Synthesis of [ O-methyl- 11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1 H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB 1 receptors
score: 1.416989, Bioorganic & Medicinal Chemistry Letters, 2004, Kumar, J.S.Dileep et. al.
A new lipophilic fluorescent probe for interaction studies of bioactive lipopeptides with membrane models
score: 1.4169165, Bioorganic & Medicinal Chemistry Letters, 2002, Peroni, Elisa et. al.
Participation of the β-hydroxyketone part for potent cytotoxicity of callystatin A, a spongean polyketide
score: 1.4166713, Bioorganic & Medicinal Chemistry, 2001, Murakami, Nobutoshi; Sugimoto, Masanori; Kobayashi, Motomasa
Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation
score: 1.416545, Bioorganic & Medicinal Chemistry Letters, 2012, Volkova, Maria S. et. al.
Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation
score: 1.416545, Bioorganic & Medicinal Chemistry Letters, 2012, Volkova, Maria S. et. al.
Preparation of classical Re/ 99mTc(CO) 3 + and novel 99mTc(CO) 2(NO) 2+ cores complexed with flavonol derivatives and their binding characteristics for Aβ (1–40) aggregates
score: 1.4162619, Bioorganic & Medicinal Chemistry Letters, 2010, Yang, Yang et. al.
Stereocontrolled synthesis of LNA Dinucleoside phosphorothioate by the oxathiaphospholane approach
score: 1.4161753, Bioorganic & Medicinal Chemistry Letters, 2001, Karwowski, Bolesław et. al.
Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids
score: 1.4161234, European Journal of Medicinal Chemistry, 2012, Bortolini, Olga et. al.
Myxobacteria versus sponge-derived alkaloids: The bengamide family identified as potent immune modulating agents by scrutiny of LC–MS/ELSD libraries
score: 1.4160317, Bioorganic & Medicinal Chemistry, 2012, Johnson, Tyler A. et. al.
Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques
score: 1.4159933, Bioorganic & Medicinal Chemistry Letters, 2011, Noha, Stefan M. et. al.
Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity
score: 1.415953, European Journal of Medicinal Chemistry, 2012, Yang, Xiao-Zhi et. al.
Chemical and enzymatic synthesis of glycoconjugates 5: One-pot regioselective synthesis of bioactive galactobiosides using a CLONEZYME TM thermophilic glycosidase library
score: 1.4159074, Bioorganic & Medicinal Chemistry Letters, 1999, Li, Jun; Robertson, Dan E.; Short, Jay M.; Wang, Peng George
Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH2
score: 1.4158869, Bioorganic & Medicinal Chemistry Letters, 2012, Somlai, Csaba et. al.
Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects
score: 1.4158832, European Journal of Medicinal Chemistry, 2012, Khurana, Jitender M. et. al.
Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects
score: 1.4158832, European Journal of Medicinal Chemistry, 2012, Khurana, Jitender M. et. al.
Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects
score: 1.4158832, European Journal of Medicinal Chemistry, 2012, Khurana, Jitender M. et. al.
Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing
score: 1.4155968, Bioorganic & Medicinal Chemistry Letters, 2009, Bernard, Sylvain et. al.
Synthesis and biological evaluation of aryl azide derivatives of combretastatin a-4 as molecular probes for tubulin
score: 1.4154841, Bioorganic & Medicinal Chemistry, 2000, Pinney, Kevin G et. al.
Studies on (β,1→5) and (β,1→6) linked octyl Gal f disaccharides as substrates for mycobacterial galactosyltransferase activity
score: 1.4154219, Bioorganic & Medicinal Chemistry, 2001, Pathak, Ashish K et. al.
Assessment of the steric tolerance of the P sector in the catalytic site of porcine liver esterase
score: 1.4154092, Bioorganic & Medicinal Chemistry Letters, 1998, Rojas-Garbanzo, Raúl E; Mata-Segreda, Julio F
Cyclopropenone-containing cysteine proteinase inhibitors. Synthesis and enzyme inhibitory activities
score: 1.4153723, Bioorganic & Medicinal Chemistry, 1999, Ando, Ryoichi et. al.
Penoxsulam—Structure–activity relationships of triazolopyrimidine sulfonamides
score: 1.4153049, Bioorganic & Medicinal Chemistry, 2009, Johnson, Timothy C. et. al.
Newly designed six-membered azasugar nucleotide-containing phosphorothioate oligonucleotides as potent human immunodeficiency virus type 1 inhibitors.
score: 1.4152606, Antimicrobial agents and chemotherapy, 2005, Lee, Dong-Seong et. al.
The synthesis and nicotinic binding activity of (±)-epiquinamide and (±)- C(1)- epiepiquinamide
score: 1.4152542, Bioorganic & Medicinal Chemistry Letters, 2006, Kanakubo, Akira et. al.
Novel cephalosporin derivatives possessing a substituted cinnamoyl moiety at the 7β-position. Synthesis, structural characterization and antibacterial activity of 3-acetoxymethyl cephalosporin derivatives
score: 1.4152538, European Journal of Medicinal Chemistry, 2004, López, Miguel A et. al.
Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis
score: 1.4152453, Bioorganic & Medicinal Chemistry, 2005, Hashimoto, Yuichi; Miyachi, Hiroyuki
Desketoneoenactin-siderophore conjugates for Candida: evidence of iron transport-dependent species selectivity.
score: 1.4151687, Antimicrobial agents and chemotherapy, 2005, Bernier, Geneviève et. al.
CoMFA-SIMCA Model for antichagasic nitrofurazone derivatives
score: 1.415071, Bioorganic & Medicinal Chemistry, 2001, Martinez-Merino, Victor; Cerecetto, Hugo
High-throughput assays for promiscuous inhibitors.
score: 1.4150533, Nature chemical biology, 2005, Feng, Brian Y et. al.
Anti-Helicobacter pylori potential of artemisinin and its derivatives.
score: 1.4150102, Antimicrobial agents and chemotherapy, 2012, Goswami, Suchandra et. al.
Diamination by N-coupling using a commercial laccase
score: 1.4149025, Bioorganic & Medicinal Chemistry, 2010, Wellington, Kevin W.; Steenkamp, Paul; Brady, Dean
In silico ADME modelling: prediction models for blood–brain barrier permeation using a systematic variable selection method
score: 1.4148989, Bioorganic & Medicinal Chemistry, 2005, Narayanan, Ramamurthi; Gunturi, Sitarama B.
Novel imidazo[1,2- a]pyrazine derivatives as potent reversible inhibitors of the gastric H +/K +-ATPase
score: 1.4148676, Bioorganic & Medicinal Chemistry, 2008, Zimmermann, Peter Jan et. al.
Synthesis and antimicrobial activity of erythromycin-A oxime analogs
score: 1.4147442, Bioorganic & Medicinal Chemistry, 2004, Pandey, Deepa; Katti, S.B; Haq, W; Tripathi, C.K.M
Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity
score: 1.4147298, European Journal of Medicinal Chemistry, 2012, Chen, Kuen-Feng et. al.
Reactivity of reduced [2Fe-2S] ferredoxins parallels host susceptibility to nitroimidazoles.
score: 1.4146913, Antimicrobial agents and chemotherapy, 2003, Vidakovic, Momcilo et. al.
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents
score: 1.4145589, Bioorganic & Medicinal Chemistry, 2005, Ismail, Mohamed A. et. al.
Synthesis and biological activity of high-affinity retinoic acid receptor antagonists
score: 1.4142927, Bioorganic & Medicinal Chemistry, 1999, Johnson, Alan T. et. al.
Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052.
score: 1.4142814, Antimicrobial agents and chemotherapy, 2012, Wang, Chunfu et. al.
Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors
score: 1.4141902, European Journal of Medicinal Chemistry, 2012, Krishnaiah, Maddeboina et. al.
Antimalarial activities and therapeutic properties of febrifugine analogs.
score: 1.4141168, Antimicrobial agents and chemotherapy, 2005, Jiang, Suping et. al.
A model of photoprobe docking with β1,4-galactosyltransferase identifies a possible carboxylate involved in glycosylation steps
score: 1.4140395, Bioorganic & Medicinal Chemistry Letters, 2001, Hatanaka, Yasumaru et. al.
Synthesis and evaluation of 2-tosylamino and 2-tosyliminopyrimidine derivatives as inhibitors of some leukocyte functions
score: 1.4139826, European Journal of Medicinal Chemistry, 2003, Fernandez-Ferri, Patricia et. al.
Carbapenem derivatives as potential inhibitors of various beta-lactamases, including class B metallo-beta-lactamases.
score: 1.4139521, Antimicrobial agents and chemotherapy, 1999, Nagano, R et. al.
Clinical status of duplex RNA
score: 1.4138174, Bioorganic & Medicinal Chemistry Letters, 2010, Watts, Jonathan K.; Corey, David R.
The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study
score: 1.4137241, European Journal of Medicinal Chemistry, 2012, Chapelat, Julien et. al.
N-(4-Bromobenzoyl)- S, S-dimethyliminosulfurane, a potent dermal penetration enhancer
score: 1.4136684, Bioorganic & Medicinal Chemistry Letters, 1999, Strekowski, Lucjan et. al.
Synthesis and antibacterial activity of 5-substituted oxazolidinones
score: 1.4135685, Bioorganic & Medicinal Chemistry, 2003, Phillips, O.A; Udo, E.E; Ali, A.A.M; Al-Hassawi, N
Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain
score: 1.4135668, European Journal of Medicinal Chemistry, 1999, Andrews, David M et. al.
Synthesis of novel mono and bis-indole conduritol derivatives and their α/β-glycosidase inhibitory effects
score: 1.4134978, Bioorganic & Medicinal Chemistry Letters, 2012, Çavdar, Hüseyin; Talaz, Oktay; Ekinci, Deniz
Synthesis of novel mono and bis-indole conduritol derivatives and their α/β-glycosidase inhibitory effects
score: 1.4134978, Bioorganic & Medicinal Chemistry Letters, 2012, Çavdar, Hüseyin; Talaz, Oktay; Ekinci, Deniz
Synthesis of novel mono and bis-indole conduritol derivatives and their α/β-glycosidase inhibitory effects
score: 1.4134978, Bioorganic & Medicinal Chemistry Letters, 2012, Çavdar, Hüseyin; Talaz, Oktay; Ekinci, Deniz
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
score: 1.4133635, Antimicrobial agents and chemotherapy, 2001, Furman, P A et. al.
Synthesis of oligodeoxyribonucleoside phosphorothioates using Lawesson's Reagent for the Sulfur Transfer Step
score: 1.4132284, Bioorganic & Medicinal Chemistry Letters, 2002, Ju, Jingyue; McKenna, Charles E.
Leishmanicidal activity of phenylene bridged C 2 symmetric glycosyl ureides
score: 1.4131558, Bioorganic & Medicinal Chemistry Letters, 2004, Tewari, Neetu et. al.
Enzymatic activation of hydrophobic self-immolative dendrimers: The effect of reporters with ionizable functional groups
score: 1.4131128, Bioorganic & Medicinal Chemistry Letters, 2009, Avital-Shmilovici, Michal; Shabat, Doron
Use of libraries to access new chemical space: Applications to CRTH2
score: 1.413101, Bioorganic & Medicinal Chemistry Letters, 2012, Abid Masood, M. et. al.
Use of libraries to access new chemical space: Applications to CRTH2
score: 1.413101, Bioorganic & Medicinal Chemistry Letters, 2012, Abid Masood, M. et. al.
Use of libraries to access new chemical space: Applications to CRTH2
score: 1.413101, Bioorganic & Medicinal Chemistry Letters, 2012, Abid Masood, M. et. al.
Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di- N-oxide derivatives
score: 1.4130245, Bioorganic & Medicinal Chemistry, 2004, Zarranz, Belén et. al.
Inhibitors of the tissue factor/factor VIIa-induced coagulation: synthesis and in vitro evaluation of novel specific 2-aryl substituted 4 H-3,1-benzoxazin-4-ones
score: 1.4127795, Bioorganic & Medicinal Chemistry, 2000, Jakobsen, Palle; Ritsmar Pedersen, Bo; Persson, Egon
Quinolone-DNA interaction: sequence-dependent binding to single-stranded DNA reflects the interaction within the gyrase-DNA complex.
score: 1.4127251, Antimicrobial agents and chemotherapy, 2003, Noble, Christian G; Barnard, Faye M; Maxwell, Anthony
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1
score: 1.4126845, Bioorganic & Medicinal Chemistry Letters, 2012, Han, Xiaojun et. al.
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1
score: 1.4126845, Bioorganic & Medicinal Chemistry Letters, 2012, Han, Xiaojun et. al.
Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted β-carboline derivatives
score: 1.4126834, European Journal of Medicinal Chemistry, 2005, Cao, Rihui et. al.
Antitumor agents. Part 186: 1 1 For part 185, see ref. [1]. Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors
score: 1.4126692, Bioorganic & Medicinal Chemistry, 1998, Guan, Jian et. al.
Design, structural and spectroscopic elucidation, and the in vitro biological activities of new diorganotin dithiocarbamates
score: 1.4126613, European Journal of Medicinal Chemistry, 2012, Ferreira, Isabella P. et. al.
Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents
score: 1.412611, Bioorganic & Medicinal Chemistry Letters, 2012, Shelke, Shivaji H. et. al.
Synthesis, dopamine D 2 receptor binding studies and docking analysis of 5-[3-(4-arylpiperazin-1-yl)propyl]-1 H-benzimidazole, 5-[2-(4-arylpiperazin-1-yl)ethoxy]-1 H-benzimidazole and their analogs
score: 1.4124578, European Journal of Medicinal Chemistry, 2005, Šukalović, V. et. al.
Eco-friendly and efficient one-pot synthesis of alkyl- or aryl-14 H-dibenzo[ a, j]xanthenes in water
score: 1.4121341, Bioorganic & Medicinal Chemistry Letters, 2008, Dabiri, Minoo et. al.
Is the anomeric effect an important factor in the rate of adenosine deaminase catalyzed hydrolysis of purine nucleosides? A direct comparison of nucleoside analogues constructed on ribose and carbocyclic templates with equivalent heterocyclic bases selected to promote hydration
score: 1.4119957, Bioorganic & Medicinal Chemistry, 2002, Hernandez, Susana; Ford, Harry; Marquez, Victor E
Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[( Z)-2′-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate
score: 1.4119843, Bioorganic & Medicinal Chemistry, 2000, Wang, Xueqing; Silverman, Richard B
Solid phase synthesis of selective caspase-3 peptide inhibitors
score: 1.4119666, Bioorganic & Medicinal Chemistry, 2004, Grimm, Erich L et. al.
N-(3-Triethoxysilylpropyl)-4-(isothiocyanatomethyl)-cyclohexane-1-carboxamide (TPICC): A heterobifunctional reagent for immobilization of biomolecules on glass surface
score: 1.4119615, Bioorganic & Medicinal Chemistry Letters, 2008, Misra, Arvind; Shahid, Mohammad; Dwivedi, Pratibha
Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol- S-conjugate amidase by natural product inhibitors
score: 1.4119266, Bioorganic & Medicinal Chemistry, 2003, Nicholas, Gillian M. et. al.
How hydrogen bonds impact P-glycoprotein transport and permeability
score: 1.4118541, Bioorganic & Medicinal Chemistry Letters, 2012, Desai, Prashant V.; Raub, Thomas J.; Blanco, Maria-Jesus
How hydrogen bonds impact P-glycoprotein transport and permeability
score: 1.4118541, Bioorganic & Medicinal Chemistry Letters, 2012, Desai, Prashant V.; Raub, Thomas J.; Blanco, Maria-Jesus
A novel QSAR model for predicting induction of apoptosis by 4-aryl-4 H-chromenes
score: 1.4118147, Bioorganic & Medicinal Chemistry, 2006, Afantitis, Antreas et. al.
New aromatic inhibitors of EPSP synthase incorporating hydroxymalonates as novel 3-phosphate replacements
score: 1.411701, Bioorganic & Medicinal Chemistry, 1997, Shah, Ajit et. al.
OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain.
score: 1.4116012, Antimicrobial agents and chemotherapy, 2000, Bou, G; Oliver, A; Martínez-Beltrán, J
Identification of Myricetin and Scutellarein as Novel Chemical Inhibitors of the SARS coronavirus helicase, nsP13
score: 1.4114833, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Mi-Sun et. al.
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa
score: 1.4114228, Bioorganic & Medicinal Chemistry, 2006, Aiello, Anna et. al.
Fluorescent nitrile-based inhibitors of cysteine cathepsins
score: 1.4113058, Bioorganic & Medicinal Chemistry Letters, 2012, Frizler, Maxim; Mertens, Matthias D.; Gütschow, Michael
2-[4,5-Difluoro-2-(2-Fluorobenzoylamino)-Benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2.
score: 1.4112115, Antimicrobial agents and chemotherapy, 2012, Strand, Mårten et. al.
Synthesis and antimicrobial studies of a new series of 2-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-5-substituted-1,3,4-oxadiazoles
score: 1.4111631, European Journal of Medicinal Chemistry, 2006, Gaonkar, S.L.; Rai, K.M.L.; Prabhuswamy, B.
Photoinduced cross-linking of RNA by cis-Rh(phen) 2Cl 2 + and cis-Rh(phen)(phi)Cl 2 +: A new family of light activatable nucleic acid cross-linking agents
score: 1.4104706, Bioorganic & Medicinal Chemistry Letters, 1999, Mohammad, Taj; Chen, Chaoping; Guo, Peixuan; Morrison, Harry
Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho- d-glyceric acid (1,3-diPG) analogues
score: 1.4104365, Bioorganic & Medicinal Chemistry, 2001, Ladame, Sylvain et. al.
Biodegradable cyclen-based linear and cross-linked polymers as non-viral gene vectors
score: 1.4102445, Bioorganic & Medicinal Chemistry, 2012, Li, Shuo et. al.
Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography
score: 1.4101387, Bioorganic & Medicinal Chemistry, 2010, Shetty, Dinesh et. al.
Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells
score: 1.4100776, Bioorganic & Medicinal Chemistry, 2006, Lindenmeyer, Maja T. et. al.
Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives
score: 1.410045, Bioorganic & Medicinal Chemistry, 2012, Göktaş, Füsun et. al.
Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives
score: 1.410045, Bioorganic & Medicinal Chemistry, 2012, Göktaş, Füsun et. al.
Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives
score: 1.410045, Bioorganic & Medicinal Chemistry, 2012, Göktaş, Füsun et. al.
Antimicrobial properties of MX-2401, an expanded-spectrum lipopeptide active in the presence of lung surfactant.
score: 1.409828, Antimicrobial agents and chemotherapy, 2011, Dugourd, Dominique et. al.
Synthesis and SAR of N-Benzoyl- l-Biphenylalanine Derivatives: Discovery of TR-14035, A Dual α 4β 7/α 4β 1 Integrin Antagonist
score: 1.4097311, Bioorganic & Medicinal Chemistry, 2002, Sircar, Ila et. al.
Synthesis of labelled PNA oligomers by a post-synthetic modification approach
score: 1.4097217, Bioorganic & Medicinal Chemistry Letters, 2003, de la Torre, Beatriz G; Eritja, Ramon
Emerging trends in molecular recognition: Utility of weak aromatic interactions
score: 1.4096186, Bioorganic & Medicinal Chemistry, 2008, Tewari, Ashish Kumar; Dubey, Rashmi
Synthesis and evaluation of bifunctional nitrocatechol inhibitors of pig liver catechol- O-methyltransferase
score: 1.4095858, Bioorganic & Medicinal Chemistry, 2005, Bailey, Karl; Tan, Eng Wui
An evaluation of automated in silico ligand docking of amino acid ligands to Family C G-protein coupled receptors
score: 1.4095277, Bioorganic & Medicinal Chemistry, 2006, Wang, Minghua; Hampson, David R.
Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA C receptors
score: 1.409492, Bioorganic & Medicinal Chemistry, 2006, Crittenden, Deborah L. et. al.
The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.
score: 1.4094607, Antimicrobial agents and chemotherapy, 2011, Daliry, A et. al.
Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD–NMR spectroscopy
score: 1.4094569, Bioorganic & Medicinal Chemistry Letters, 2006, Milton, Mark J.; Thomas Williamson, R.; Koehn, Frank E.
Synthesis and antimicrobial activity of new (E)-4-[piperidino (4'-methylpiperidino-, morpholino-) N-alkoxy]stilbenes
score: 1.4094385, European Journal of Medicinal Chemistry, 2006, Wyrzykiewicz, Elżbieta; Wendzonka, Monika; Kędzia, Bogdan
Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7)
score: 1.4094194, European Journal of Medicinal Chemistry, 2013, Sharma, Abhinay et. al.
Synthesis and characterization of some new complexes of Cu(II), Ni(II) and V(IV) with Schiff base derived from indole-3-carboxaldehyde. Biological activity on prokaryotes and eukaryotes
score: 1.4092372, European Journal of Medicinal Chemistry, 2012, Rosu, Tudor et. al.
Synthesis and characterization of some new complexes of Cu(II), Ni(II) and V(IV) with Schiff base derived from indole-3-carboxaldehyde. Biological activity on prokaryotes and eukaryotes
score: 1.4092372, European Journal of Medicinal Chemistry, 2012, Rosu, Tudor et. al.
Synthesis and characterization of some new complexes of Cu(II), Ni(II) and V(IV) with Schiff base derived from indole-3-carboxaldehyde. Biological activity on prokaryotes and eukaryotes
score: 1.4092372, European Journal of Medicinal Chemistry, 2012, Rosu, Tudor et. al.
A crowdsourcing evaluation of the NIH chemical probes.
score: 1.409232, Nature chemical biology, 2009, Oprea, Tudor I et. al.
A benzothiazole alkyne fluorescent sensor for Cu detection in living cell
score: 1.4092167, Bioorganic & Medicinal Chemistry Letters, 2012, Qi, Jianjun; Han, Myung Shin; Tung, Ching-Hsuan
Myxobacteria versus sponge-derived alkaloids: The bengamide family identified as potent immune modulating agents by scrutiny of LC–MS/ELSD libraries
score: 1.4091403, Bioorganic & Medicinal Chemistry, 2012, Johnson, Tyler A. et. al.
Myxobacteria versus sponge-derived alkaloids: The bengamide family identified as potent immune modulating agents by scrutiny of LC–MS/ELSD libraries
score: 1.4091403, Bioorganic & Medicinal Chemistry, 2012, Johnson, Tyler A. et. al.
Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin.
score: 1.4090074, Antimicrobial agents and chemotherapy, 2001, Shimizu, M et. al.
2′-Deoxy-2′( S)-ethinyl oligonucleotides: A modification which selectively stabilizes oligoadenylate pairing to DNA complements
score: 1.4089911, Bioorganic & Medicinal Chemistry Letters, 1998, Buff, Rolf; Hunziker, Jürg
An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae.
score: 1.4089338, Antimicrobial agents and chemotherapy, 2012, Agnew, Christopher R J et. al.
Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue
score: 1.4088234, Bioorganic & Medicinal Chemistry, 2006, Wang, Yuqiang et. al.
Piericidins C 5 and C 6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.
score: 1.4086438, Bioorganic & Medicinal Chemistry, 2003, Kubota, Natsuki K et. al.
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases
score: 1.4084761, Bioorganic & Medicinal Chemistry, 2006, Deschamps, Joshua D.; Kenyon, Victor A.; Holman, Theodore R.
Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs.
score: 1.4083912, Antimicrobial agents and chemotherapy, 2008, Nakata, Hirotomo et. al.
Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.
score: 1.408313, Antimicrobial agents and chemotherapy, 2006, Zhang, Zhijun et. al.
Vascular barrier protective effects of eckol and its derivatives
score: 1.4082097, Bioorganic & Medicinal Chemistry Letters, 2012, Hoon Kim, Tae; Lee, Taeho; Ku, Sae-Kwang; Bae, Jong-Sup
Cooperative lectin recognition of periodical glycoclusters along DNA duplexes: alternate hybridization and full hybridization
score: 1.4081026, Bioorganic & Medicinal Chemistry, 2005, Yamada, Yoshinao; Matsuura, Kazunori; Kobayashi, Kazukiyo
Studies on the antimicrobial properties of N-acylated ciprofloxacins
score: 1.4080025, Bioorganic & Medicinal Chemistry Letters, 2012, Cormier, Ryan et. al.
Improvement of base selectivity and binding affinity by controlling hydrogen bonding motifs between nucleobases and isoxanthopterin: Application to the detection of T/C mutation
score: 1.4079831, Bioorganic & Medicinal Chemistry Letters, 2007, Rajendar, Burki et. al.
Quantitative structure activity relationship of benzoxazinone derivatives as neuropeptide Y Y5 receptor antagonists
score: 1.4077933, European Journal of Medicinal Chemistry, 2006, Deswal, S.; Roy, N.
Insight into 2-phenylpyrazolo[1,5- a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation
score: 1.4075971, Bioorganic & Medicinal Chemistry, 2005, Selleri, Silvia et. al.
Synthesis and biology of 3′- N-acyl- N-debenzoylpaclitaxel analogues
score: 1.407362, Bioorganic & Medicinal Chemistry, 1999, Roh, Eun Joo et. al.
Radical scavenging activity of dicaffeoyloxycyclohexanes: Contribution of an intramolecular interaction of two caffeoyl residues
score: 1.4072393, Bioorganic & Medicinal Chemistry, 2005, Saito, Shizuka et. al.
Isolation of new bioactive annonaceous acetogenins from Rollinia mucosa guided by liquid chromatography/mass spectrometry
score: 1.4071439, Bioorganic & Medicinal Chemistry, 1997, Gu, Zhe-ming et. al.
Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
score: 1.4070838, Bioorganic & Medicinal Chemistry, 2006, Mosley, Sylvester L. et. al.
New quinazolinone–pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies
score: 1.4070137, European Journal of Medicinal Chemistry, 2012, Abbas, Safinaz E. et. al.
New quinazolinone–pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies
score: 1.4070137, European Journal of Medicinal Chemistry, 2012, Abbas, Safinaz E. et. al.
Triketones active against antibiotic-resistant bacteria: Synthesis, structure–activity relationships, and mode of action
score: 1.4069489, Bioorganic & Medicinal Chemistry, 2005, van Klink, John W. et. al.
Discovery of a muscarinic M 3 receptor antagonist with high selectivity for M 3 over M 2 receptors among 2-[(1 S,3 S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives
score: 1.4068888, Bioorganic & Medicinal Chemistry, 2000, Mitsuya, Morihiro et. al.
Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo.
score: 1.4067297, Antimicrobial agents and chemotherapy, 2011, Brackman, Gilles et. al.
Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives
score: 1.4066494, European Journal of Medicinal Chemistry, 2012, He, Xianran et. al.
Structural–activity relationship study on C-4 carbon atom of the CB 1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides
score: 1.4066443, European Journal of Medicinal Chemistry, 2006, Jagerovic, Nadine et. al.
Syntheses, biological evaluation and QSAR study on antitumor activity of 1,5- N, N′-disubstituted-2-(substituted benzenesulphonyl) glutamamides
score: 1.4063027, Bioorganic & Medicinal Chemistry, 2002, Srikanth, K.; Debnath, Bikash; Jha, Tarun
An efficient chemical approach to bispecific antibodies and antibodies of high valency
score: 1.4062963, Bioorganic & Medicinal Chemistry Letters, 2009, Gavrilyuk, Julia I. et. al.
Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses.
score: 1.4062429, Antimicrobial agents and chemotherapy, 2012, Muratore, Giulia et. al.
Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum
score: 1.4061828, Bioorganic & Medicinal Chemistry, 2006, Anderson, Marc O. et. al.
Efficient microwave-assisted direct radiosynthesis of [ 18F]PR04.MZ and [ 18F]LBT999: Selective dopamine transporter ligands for quantitative molecular imaging by means of PET
score: 1.4061504, Bioorganic & Medicinal Chemistry, 2009, Riss, Patrick J.; Roesch, Frank
Diaryl naphthyl methanes a novel class of anti-implantation agents
score: 1.4061352, Bioorganic & Medicinal Chemistry, 2004, Srivastava, Neeta et. al.
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones
score: 1.4061091, European Journal of Medicinal Chemistry, 2003, Dimmock, Jonathan R et. al.
Nicorandil analogues containing NO-donor furoxans and related furazans
score: 1.4060349, Bioorganic & Medicinal Chemistry, 2000, Boschi, Donatella et. al.
Investigating the structural basis of arylamides to improve potency against M. tuberculosis strain through molecular dynamics simulations
score: 1.4058716, European Journal of Medicinal Chemistry, 2010, Punkvang, Auradee et. al.
2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone
score: 1.40583, Bioorganic & Medicinal Chemistry, 2004, Costi, Roberta et. al.
Oligonucleotides with strongly fluorescent groups π-Conjugated to a nucleobase: syntheses, melting temperatures, and conformation
score: 1.4057797, Bioorganic & Medicinal Chemistry Letters, 2003, Jiao, Guan-Sheng; Burgess, Kevin
Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein
score: 1.4057662, Bioorganic & Medicinal Chemistry Letters, 2005, Manna, Fedele et. al.
Design, synthesis, photochemical properties and cytotoxic activities of water-Soluble caged l-Leucyl- l-leucine methyl esters that control apoptosis of immune cells
score: 1.4055782, Bioorganic & Medicinal Chemistry, 2002, Mizuta, Hironori et. al.
Hydrazones of 1,2-benzisothiazole hydrazides: synthesis, antimicrobial activity and QSAR investigations
score: 1.4053444, European Journal of Medicinal Chemistry, 2002, Vicini, Paola et. al.
On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors
score: 1.4053237, Bioorganic & Medicinal Chemistry, 2006, Robins, Lori I. et. al.
Solid phase synthesis of N-carboxy alkyl-containing peptides derived from enantiopure αketo-β-aminoacids
score: 1.4052997, Bioorganic & Medicinal Chemistry Letters, 1998, Fermández-García, Concepción et. al.
Exploring distal regions of the A 3 adenosine receptor binding site: sterically constrained N 6-(2-phenylethyl)adenosine derivatives as potent ligands
score: 1.4051832, Bioorganic & Medicinal Chemistry, 2004, Tchilibon, Susanna et. al.
An Efficient Protocol for Solution- and Solid-Phase End-Group Differentiation of Spermidine
score: 1.4051642, Bioorganic & Medicinal Chemistry Letters, 2002, Silva, Emerson T; Cunha, Andréa S; Lima, Edson L.S
Synthesis and characterization of pH-sensitive conjugate of isoniazid – methoxypoly(ethylene glycol)-b-poly(l-lysine)
score: 1.4050854, Bioorganic & Medicinal Chemistry Letters, 2012, Imramovský, Aleš et. al.
Synthesis, characterization and pharmacological properties of some 4-arylhydrazono-2-pyrazoline-5-one derivatives obtained from heterocyclic amines
score: 1.4049318, European Journal of Medicinal Chemistry, 2000, Güniz Küçükgüzel, Ş et. al.
From Heptahelical Bundle to Hits from the Haystack-Chapter Fifteen:Structure-Based Virtual Screening for GPCR Ligands
score: 1.4048621, Methods in Enzymology, 2013, Kooistra, Albert J. et. al.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
score: 1.4047857, Bioorganic & Medicinal Chemistry Letters, 2012, Davies, Christopher W. et. al.
C 2-Symmetric inhibitors of Plasmodium falciparum plasmepsin II: synthesis and theoretical predictions
score: 1.4047305, Bioorganic & Medicinal Chemistry, 2003, Ersmark, Karolina et. al.
Synthesis and Cytotoxic Activities of Estrone and Estradiol cis-Dichloroplatinum(II) Complexes
score: 1.4046984, Bioorganic & Medicinal Chemistry, 2012, Kvasnica, Miroslav et. al.
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives
score: 1.4046405, Bioorganic & Medicinal Chemistry, 2005, Doláková, Petra et. al.
Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli.
score: 1.4044629, Antimicrobial agents and chemotherapy, 2005, Gauthier, Annick et. al.
Synthesis, characterization and DNA-binding properties of four Zn(II) complexes with bis(pyrrol-2-yl-methyleneamine) ligands
score: 1.4043755, Bioorganic & Medicinal Chemistry Letters, 2008, Wang, Yuan; Yang, Zheng-Yin; Chen, Zhong-Ning
Exploration of ring size in a series of cyclic vicinal diamines with σ1 receptor affinity
score: 1.4042461, Bioorganic & Medicinal Chemistry Letters, 2012, Moussa, Iman A. et. al.
A convenient one-step synthesis of l-aminotryptophans and improved synthesis of 5-fluorotryptophan
score: 1.4042199, Bioorganic & Medicinal Chemistry Letters, 2008, Winn, Michael et. al.
In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria.
score: 1.4041813, Antimicrobial agents and chemotherapy, 2004, Braunstein, Amir; Papo, Niv; Shai, Yechiel
Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening
score: 1.4041324, Bioorganic & Medicinal Chemistry Letters, 2009, McLean, Larry R. et. al.
Metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro.
score: 1.4040724, Antimicrobial agents and chemotherapy, 1998, Dutschman, G E et. al.
Synthesis of 3-hydroxypyrid-2-ones from furfural for treatment against iron overload and iron deficiency
score: 1.4040346, European Journal of Medicinal Chemistry, 2008, Samant, Bhupesh S.
Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety
score: 1.4038985, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Chuan et. al.
Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety
score: 1.4038985, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Chuan et. al.
Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety
score: 1.4038985, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Chuan et. al.
Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid
score: 1.403578, Bioorganic & Medicinal Chemistry Letters, 2010, Seshime, Yasuyo et. al.
Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents
score: 1.4033894, Bioorganic & Medicinal Chemistry, 2006, Shin, Dae-Seop et. al.
Naphtho[2,1- b][1,5] and [1,2- f][1,4]oxazocines as selective NK 1 antagonists
score: 1.4032419, Bioorganic & Medicinal Chemistry, 2004, Ohnmacht, Cyrus J. et. al.
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C6 position
score: 1.4032226, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Sun Ea; Pflum, Mary Kay H.
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C6 position
score: 1.4032226, Bioorganic & Medicinal Chemistry Letters, 2012, Choi, Sun Ea; Pflum, Mary Kay H.
Structural analysis of chloroquine resistance reversal by imipramine analogs.
score: 1.4031627, Antimicrobial agents and chemotherapy, 2001, Bhattacharjee, A K; Kyle, D E; Vennerstrom, J L
Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin
score: 1.4031127, Bioorganic & Medicinal Chemistry, 2013, Handzlik, Jadwiga et. al.
Comparative molecular field analysis and QSAR on substrates binding to cytochrome P450 2D6
score: 1.4030674, Bioorganic & Medicinal Chemistry, 2003, Haji-Momenian, Shahriar et. al.
Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity.
score: 1.4028104, Antimicrobial agents and chemotherapy, 2007, Caughey, Winslow S et. al.
Facile preparation of DNA-tagged carbohydrates
score: 1.4027642, Bioorganic & Medicinal Chemistry Letters, 2003, Sando, Shinsuke et. al.
Isoxazolo-[3,4- d]-pyridazin-7-(6 H)-ones and their Corresponding 4,5-Disubstituted-3-(2 H)-pyridazinone Analogues as New Substrates for α 1-Adrenoceptor Selective Antagonists: Synthesis, Modeling, and Binding Studies
score: 1.4026528, Bioorganic & Medicinal Chemistry, 1998, Montesano, Federica et. al.
A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors
score: 1.4026457, European Journal of Medicinal Chemistry, 2007, Deswal, Sumit; Roy, Nilanjan
Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides
score: 1.4025823, Bioorganic & Medicinal Chemistry Letters, 1998, Weiner, Warren S; Hamilton, Andrew D
A dimeric form of N-methoxycarbonyl-2-amino-1,8-naphthyridine bound to the A–A mismatch in the CAG/CAG base triad in dsRNA
score: 1.402581, Bioorganic & Medicinal Chemistry Letters, 2013, Nakatani, Kazuhiko; Toda, Mariko; He, Hanping
Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities
score: 1.4025385, European Journal of Medicinal Chemistry, 2012, Sipos, Attila et. al.
Synthesis and cytotoxic activity of tetracenomycin d and of saintopin analogues
score: 1.4023907, Bioorganic & Medicinal Chemistry, 2002, Martin, Philippe et. al.
Efficient synthesis of rhodamine conjugates through the 2′-position
score: 1.4022754, Bioorganic & Medicinal Chemistry Letters, 2000, Adamczyk, Maciej; Grote, Jonathan
Modulation of the Cs 2CO 3-promoted catalytic amination by a crown ether
score: 1.402216, Bioorganic & Medicinal Chemistry Letters, 2000, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Potent activity of a PK/PBAN analog with an ( E)-alkene, trans-Pro mimic identifies the Pro orientation and core conformation during interaction with HevPBANR-C receptor
score: 1.4021903, Bioorganic & Medicinal Chemistry, 2009, Nachman, Ronald J. et. al.
Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents
score: 1.4019699, European Journal of Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents
score: 1.4019699, European Journal of Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology
score: 1.4017783, Bioorganic & Medicinal Chemistry Letters, 2005, Takakusagi, Yoichi et. al.
Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A2 activity
score: 1.4017005, Bioorganic & Medicinal Chemistry, 2012, Pedersen, Palle J. et. al.
Synthesis and hybridization property of an oligonucleotide analog containing A 1′,3′-DI- O-methylene-α- D-fructose backbone
score: 1.4016135, Bioorganic & Medicinal Chemistry Letters, 1998, Zou, Ruiming; Matteucci, Mark D.
Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori.
score: 1.4015806, Antimicrobial agents and chemotherapy, 2002, Sisson, Gary et. al.
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes
score: 1.4014157, European Journal of Medicinal Chemistry, 2012, Ferraz, Karina S.O. et. al.
In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model.
score: 1.4013525, Antimicrobial agents and chemotherapy, 2011, Louie, Arnold; Liu, Weiguo; Kulawy, Robert; Drusano, G L
Mannich reaction: an approach for the synthesis of water soluble mulundocandin analogues
score: 1.4010707, Bioorganic & Medicinal Chemistry, 2004, Lal, Bansi et. al.
Investigation of the Binding Pocket of Human Hematopoietic Prostaglandin (PG) D2 Synthase (hH-PGDS): A Tale of Two Waters
score: 1.4009937, Bioorganic & Medicinal Chemistry Letters, 2012, Trujillo, John I. et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity
score: 1.4009655, Bioorganic & Medicinal Chemistry, 2012, Li, Xi et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity
score: 1.4009655, Bioorganic & Medicinal Chemistry, 2012, Li, Xi et. al.
A Co(III) complex cleaving soluble oligomers of h-IAPP in the presence of polymeric aggregates of h-IAPP
score: 1.4009325, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Tae Yeon et. al.
A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues
score: 1.4006132, European Journal of Medicinal Chemistry, 2003, Wellendorph, Petrine et. al.
2D-QSAR in hydroxamic acid derivatives as peptide deformylase inhibitors and antibacterial agents
score: 1.4005346, Bioorganic & Medicinal Chemistry, 2002, Gupta, Manish K et. al.
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2
score: 1.4004954, Bioorganic & Medicinal Chemistry, 2007, Zheng, Fang et. al.
Arylmethyl substituted derivatives of Fosmidomycin: Synthesis and antimalarial activity
score: 1.4004607, European Journal of Medicinal Chemistry, 2006, Schlüter, Katrin et. al.
2-Amino-α-2′-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate α-Oligodeoxynucleotides with RNA target
score: 1.4004281, Bioorganic & Medicinal Chemistry Letters, 2002, Naval, Magali et. al.
Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation
score: 1.4004032, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Eonjeong et. al.
Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation
score: 1.4004032, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Eonjeong et. al.
Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation
score: 1.4004032, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Eonjeong et. al.
Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents
score: 1.4003992, Bioorganic & Medicinal Chemistry, 2004, Micale, Nicola et. al.
Synthesis and biological evaluation of 18F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging
score: 1.4003865, Bioorganic & Medicinal Chemistry, 2013, Wang, Xia et. al.
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.
score: 1.4003862, Antimicrobial agents and chemotherapy, 2003, Choudhry, Anthony E et. al.
Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid
score: 1.4003499, Bioorganic & Medicinal Chemistry, 2000, Valenti, Piero et. al.
O–N Intramolecular acyl migration strategy in water-soluble prodrugs of taxoids
score: 1.4001375, Bioorganic & Medicinal Chemistry Letters, 2003, Skwarczynski, Mariusz et. al.
Inhibitors of the glycine transporter type-2 (GlyT-2): synthesis and biological activity of benzoylpiperidine derivatives
score: 1.3999311, Bioorganic & Medicinal Chemistry, 2004, Wolin, Ronald L et. al.
Antioxidant activity of novel chitin derivative
score: 1.399856, Bioorganic & Medicinal Chemistry Letters, 2006, Je, Jae-Young; Kim, Se-Kwon
Activity of ceftaroline-avibactam tested against Gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various staphylococcal cassette chromosome mec types.
score: 1.3998422, Antimicrobial agents and chemotherapy, 2012, Castanheira, Mariana et. al.
Dual action spirobicycloimidazolidine-2,4-diones: Antidiabetic agents and inhibitors of aldose reductase-an enzyme involved in diabetic complications
score: 1.3997517, Bioorganic & Medicinal Chemistry Letters, 2013, Iqbal, Zafar et. al.
Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells
score: 1.3997436, Bioorganic & Medicinal Chemistry, 2006, Prabhakar, B.T. et. al.
Site-specific conjugation of oligonucleotides to the C-terminus of recombinant protein by expressed protein ligation
score: 1.3997208, Bioorganic & Medicinal Chemistry Letters, 2004, Takeda, Shuji; Tsukiji, Shinya; Nagamune, Teruyuki
Novel substrates for nitric oxide synthases
score: 1.3997091, Bioorganic & Medicinal Chemistry, 2002, Xian, Ming et. al.
A new boronic acid based fluorescent reporter for catechol
score: 1.399652, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Zhongyu; Li, Minyong; Fang, Hao; Wang, Binghe
New 1,2,3-triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors. II
score: 1.3996205, European Journal of Medicinal Chemistry, 2002, Biagi, Giuliana et. al.
Heterocyclic rimantadine analogues with antiviral activity
score: 1.399606, Bioorganic & Medicinal Chemistry, 2006, Zoidis, Grigoris et. al.
Bisquaternary dimers of strychnine and brucine. A new class of potent enhancers of antagonist binding to muscarinic M 2 receptors
score: 1.3995989, Bioorganic & Medicinal Chemistry, 2003, Zlotos, D.P.; Buller, S.; Holzgrabe, U.; Mohr, K.
Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action
score: 1.399583, Bioorganic & Medicinal Chemistry, 2000, Nakano, Hiroyuki et. al.
Anticancer activity of small amphipathic β2,2-amino acid derivatives
score: 1.3995148, European Journal of Medicinal Chemistry, 2012, Hansen, Terkel et. al.
Anticancer activity of small amphipathic β2,2-amino acid derivatives
score: 1.3995148, European Journal of Medicinal Chemistry, 2012, Hansen, Terkel et. al.
Structure–activity relationship study on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge Mycale adhaerens
score: 1.3993435, Bioorganic & Medicinal Chemistry, 2005, Nishimura, Shinichi et. al.
Quantitative structure–activity relationship of spirosuccinimide type aldose reductase inhibitors diminishing sorbitol accumulation in vivo
score: 1.3992586, Bioorganic & Medicinal Chemistry, 2006, Ko, Kwangseok; Won, Hoshik; Won, Youngdo
Solid-phase synthesis of c(RGDfK) derivatives: on-resin cyclisation and lysine functionalisation
score: 1.3992304, Bioorganic & Medicinal Chemistry Letters, 2002, McCusker, Catherine F et. al.
Synthesis, DNA-binding affinities, and binding mode of berberine dimers
score: 1.3992239, Bioorganic & Medicinal Chemistry, 2006, Qin, Yong et. al.
Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria.
score: 1.3990385, Antimicrobial agents and chemotherapy, 2000, McNicholas, P M et. al.
Discovery of new chemical leads for selective EP1 receptor antagonists
score: 1.3989926, Bioorganic & Medicinal Chemistry, 2006, Naganawa, Atsushi et. al.
Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing Sydnone
score: 1.3988622, European Journal of Medicinal Chemistry, 2012, Nithinchandra, ; Kalluraya, B.; Aamir, S.; Shabaraya, A.R.
Synthesis and evaluation of antiproliferative activity of a geldanamycin–Herceptin™ immunoconjugate
score: 1.3988412, Bioorganic & Medicinal Chemistry Letters, 2000, Mandler, Raya et. al.
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring
score: 1.3988043, Bioorganic & Medicinal Chemistry, 2006, Messaoudi, Samir et. al.
Anticancer activity of small amphipathic β2,2-amino acid derivatives
score: 1.3987995, European Journal of Medicinal Chemistry, 2012, Hansen, Terkel et. al.
Quantitative Proteome–Property Relationships (QPPRs). Part 1: Finding biomarkers of organic drugs with mean Markov connectivity indices of spiral networks of blood mass spectra
score: 1.398792, Bioorganic & Medicinal Chemistry, 2008, Cruz-Monteagudo, Maykel et. al.
Structural characteristics of novel symmetrical diaryl derivatives with nitrogenated functions. Requirements for cytotoxic activity
score: 1.3987792, Bioorganic & Medicinal Chemistry, 2006, Font, María et. al.
Novel adenosine A 1 receptor antagonists. Synthesis and structure–activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5- a]pyridines
score: 1.3986718, Bioorganic & Medicinal Chemistry, 2000, Kuroda, Satoru et. al.
New targeting system for antimycotic drugs: β-Glucosidase sensitive Amphotericin B–star poly(ethylene glycol) conjugate
score: 1.3986252, Bioorganic & Medicinal Chemistry Letters, 2008, Sedlák, Miloš et. al.
Synthesis and biological evaluation of new vinyl ester pseudotripeptide proteasome inhibitors
score: 1.3985032, European Journal of Medicinal Chemistry, 2006, Marastoni, M. et. al.
[ 3H]-MRE 2029-F20, a selective antagonist radioligand for the human A 2B adenosine receptors
score: 1.3983503, Bioorganic & Medicinal Chemistry Letters, 2004, Baraldi, Pier Giovanni et. al.
Rational design, synthesis, and pharmacological Properties of pyranochalcone derivatives as potent anti-inflammatory agents
score: 1.3982295, European Journal of Medicinal Chemistry, 2012, Peng, Fei et. al.
A frame shifted disulfide bridged analogue of angiotensin II
score: 1.3981509, Bioorganic & Medicinal Chemistry, 2003, Schmidt, Boris et. al.
Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile
score: 1.3981114, Bioorganic & Medicinal Chemistry, 2012, Toba, Tetsuya et. al.
Design, synthesis and antiviral activity of novel quinazolinones
score: 1.3980936, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
Design, synthesis and antiviral activity of novel quinazolinones
score: 1.3980936, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
Design, synthesis and antiviral activity of novel quinazolinones
score: 1.3980936, European Journal of Medicinal Chemistry, 2012, Wang, Ziwen et. al.
In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir.
score: 1.3980374, Antimicrobial agents and chemotherapy, 2000, Colledge, D; Civitico, G; Locarnini, S; Shaw, T
Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition.
score: 1.397924, Antimicrobial agents and chemotherapy, 2010, Miethke, Marcus; Skerra, Arne
Synthesis of biologically active biotinylated muramyl dipeptides
score: 1.3978988, Bioorganic & Medicinal Chemistry Letters, 2010, Grimes, Catherine Leimkuhler et. al.
Novel fluoropeptidomimetics: synthesis, stability studies and protease inhibition
score: 1.3978723, Bioorganic & Medicinal Chemistry, 2005, Annedi, Subhash C. et. al.
Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors
score: 1.3978478, Bioorganic & Medicinal Chemistry, 2012, Li, Yao et. al.
Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors
score: 1.3978478, Bioorganic & Medicinal Chemistry, 2012, Li, Yao et. al.
Synthesis of novel mono and bis-indole conduritol derivatives and their α/β-glycosidase inhibitory effects
score: 1.3978357, Bioorganic & Medicinal Chemistry Letters, 2012, Çavdar, Hüseyin; Talaz, Oktay; Ekinci, Deniz
Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40
score: 1.3978247, Bioorganic & Medicinal Chemistry Letters, 2012, Peng, Jixing et. al.
Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40
score: 1.3978247, Bioorganic & Medicinal Chemistry Letters, 2012, Peng, Jixing et. al.
Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40
score: 1.3978247, Bioorganic & Medicinal Chemistry Letters, 2012, Peng, Jixing et. al.
Enzymatic synthesis of l-6-hydroxynorleucine
score: 1.397821, Bioorganic & Medicinal Chemistry, 1999, Hanson, Ronald L. et. al.
Discovery of selective, small-molecule inhibitors of RNA complexes—II. Self-splicing group I intron ribozyme
score: 1.3977574, Bioorganic & Medicinal Chemistry, 1997, Mei, Houng-Yau et. al.
Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with β-cyclodextrin
score: 1.3977291, European Journal of Medicinal Chemistry, 2004, Kadri, Mekki et. al.
Synthesis of imidazoline and imidazo[2,1- c][1,2,4]triazole aryl derivatives containing the methylthio group as possible antibacterial agents
score: 1.397678, Bioorganic & Medicinal Chemistry, 2006, Sztanke, Krzysztof et. al.
Synthesis, antiviral, and anti-HIV-1 integrase activities of 3-aroyl-1,1-dioxo-1,4,2-benzodithiazines
score: 1.3972572, Bioorganic & Medicinal Chemistry, 2004, Brzozowski, Zdzislaw et. al.
Pharmacodynamics of TD-1792, a novel glycopeptide-cephalosporin heterodimer antibiotic used against Gram-positive bacteria, in a neutropenic murine thigh model.
score: 1.3971705, Antimicrobial agents and chemotherapy, 2012, Hegde, Sharath S et. al.
Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines
score: 1.3971131, Bioorganic & Medicinal Chemistry, 2006, Tripathi, R.P. et. al.
New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells
score: 1.3970839, Bioorganic & Medicinal Chemistry Letters, 2012, Ding, Liqin et. al.
New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells
score: 1.3970839, Bioorganic & Medicinal Chemistry Letters, 2012, Ding, Liqin et. al.
New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells
score: 1.3970839, Bioorganic & Medicinal Chemistry Letters, 2012, Ding, Liqin et. al.
Structure–activity relationship of Aza-steroids as PI-PLC inhibitors
score: 1.3970647, Bioorganic & Medicinal Chemistry, 2001, Xie, Wenge et. al.
Novel milrinone analogs of pyridine-3-carbonitrile derivatives as promising cardiotonic agents
score: 1.3966916, European Journal of Medicinal Chemistry, 2005, Bekhit, Adnan A.; Baraka, Azza M.
Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β
score: 1.3966835, Bioorganic & Medicinal Chemistry, 2013, Kuriyama, Isoko et. al.
Synthesis and properties of 2′- O,4′- C-methyleneoxymethylene bridged nucleic acid
score: 1.396592, Bioorganic & Medicinal Chemistry, 2006, Hari, Yoshiyuki et. al.
Three-dimensional quantitative structure activity relationships (3-D-QSAR) of antihyperglycemic agents
score: 1.3965383, Bioorganic & Medicinal Chemistry, 1999, Kulkarni, Santosh S; Gediya, Lalji K; Kulkarni, Vithal M
Synthesis and in vitro activity of a series 1β-methylcarbapenem derivatives
score: 1.3964146, European Journal of Medicinal Chemistry, 2006, Jeon, H.C.; Kim, J.-W.; Hong, J.H.; Cho, J.-H.; Oh, C.-H.
Synthesis and biodistribution of [ 11C]R107474, a new radiolabeled α 2-adrenoceptor antagonist
score: 1.3963719, Bioorganic & Medicinal Chemistry, 2006, Van der Mey, M. et. al.
Catalysis of imido group hydrolysis in a maleimide conjugate
score: 1.3961749, Bioorganic & Medicinal Chemistry Letters, 2007, Kalia, Jeet; Raines, Ronald T.
Triarylethylene bisphenols with a novel cycle are ligands for the estrogen receptor
score: 1.3961085, Bioorganic & Medicinal Chemistry, 2000, Kim, Sung-Hoon; Katzenellenbogen, John A.
Convenient and highly effective fluorescence sensing for Hg 2+ in aqueous solution and thin film
score: 1.3960264, Bioorganic & Medicinal Chemistry, 2009, Liu, Yu; Yu, Miao; Chen, Yong; Zhang, Ning
Synthesis and evaluation of novel 8-oxo-8 H-cyclopenta[ a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor
score: 1.3960256, Bioorganic & Medicinal Chemistry Letters, 2006, Liu, Yan et. al.
Mechanism of active renal tubular efflux of tenofovir.
score: 1.3959318, Antimicrobial agents and chemotherapy, 2006, Ray, Adrian S et. al.
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098
score: 1.3959129, Bioorganic & Medicinal Chemistry, 2006, Kurz, Thomas et. al.
Carbohydrate transition state mimics: synthesis of imidazolo-Pyrrolidinoses as potential nectrisine surrogates
score: 1.3955366, Bioorganic & Medicinal Chemistry, 2003, Tschamber, Théophile et. al.
Syntheses and biological activity of bisdaunorubicins
score: 1.3954872, Bioorganic & Medicinal Chemistry, 2006, Zhang, Guisheng et. al.
Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase
score: 1.3953628, Bioorganic & Medicinal Chemistry, 2008, Zhang, Lixia et. al.
Metronidazole thiosalicylate conjugates: Synthesis, crystal structure, docking studies and antiamoebic activity
score: 1.3953182, Bioorganic & Medicinal Chemistry Letters, 2012, Salahuddin, Attar et. al.
Molecular beacon-based quantitiation of epithelial tumor marker mucin 1
score: 1.395296, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Seonmi et. al.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
score: 1.395292, Bioorganic & Medicinal Chemistry Letters, 2012, Davies, Christopher W. et. al.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
score: 1.395292, Bioorganic & Medicinal Chemistry Letters, 2012, Davies, Christopher W. et. al.
Synthesis and biological evaluation of aromatic enones related to curcumin
score: 1.3951722, Bioorganic & Medicinal Chemistry, 2005, Robinson, Thomas Philip et. al.
Stereocontrolled synthesis of anticancer β-lactams via the Staudinger reaction
score: 1.3950146, Bioorganic & Medicinal Chemistry, 2005, Banik, Bimal K.; Banik, Indrani; Becker, Frederick F.
Microwave assisted synthesis of fragrant jasmone heterocyclic analogues
score: 1.3949291, European Journal of Medicinal Chemistry, 2006, Pawełczyk, Anna; Zaprutko, Lucjusz
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.
score: 1.3949272, Antimicrobial agents and chemotherapy, 2005, Lee, William A et. al.
A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2′-dithiobisbenzamides
score: 1.3948882, Bioorganic & Medicinal Chemistry, 1997, Domagala, John M. et. al.
2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: Synthesis and pharmacological evaluation
score: 1.394668, Bioorganic & Medicinal Chemistry, 2006, Thirumurugan, Rathinasabapathy et. al.
Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571.
score: 1.3946058, Antimicrobial agents and chemotherapy, 2012, Leeds, J A et. al.
Studies on β- d-Gal f -(1→4)-α- l-Rha p octyl analogues as substrates for mycobacterial galactosyl transferase activity
score: 1.3945779, Bioorganic & Medicinal Chemistry, 1999, Pathak, Ashish K. et. al.
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines
score: 1.3945441, Bioorganic & Medicinal Chemistry Letters, 2012, Vullo, Daniela et. al.
Comparative Pharmacodynamics of the New Oxazolidinone Tedizolid Phosphate and Linezolid in a Neutropenic Murine Staphylococcus aureus Pneumonia Model.
score: 1.3944194, Antimicrobial agents and chemotherapy, 2012, Lepak, Alexander J et. al.
Synthesis and antibacterial activity of 1β-methyl-2-[5-( N-substituted-2-hydroxy iminoethyl)pyrrolidin-3-ylthio]carbapenem derivatives
score: 1.3943998, European Journal of Medicinal Chemistry, 2003, Oh, Chang-Hyun; Lee, Su-Chul; Cho, Jung-Hyuck
Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators
score: 1.394295, Bioorganic & Medicinal Chemistry, 2006, Charton, Julie et. al.
Fluorogenic assay of alkaline phosphatase activity based on the modulation of excited-state intramolecular proton transfer
score: 1.3942688, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Jihye; Helal, Aasif; Kim, Hong-Seok; Kim, Youngmi
In vitro and in vivo effects of soluble, monovalent globotriose on bacterial attachment and colonization.
score: 1.3942659, Antimicrobial agents and chemotherapy, 2005, Leach, James L et. al.
Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase
score: 1.3941811, Bioorganic & Medicinal Chemistry, 2005, Chand, Pooran et. al.
Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors
score: 1.3941625, Bioorganic & Medicinal Chemistry, 2003, Frick, Wendelin et. al.
Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity
score: 1.3940018, Bioorganic & Medicinal Chemistry, 1997, Takusagawa, Fusao et. al.
In vitro activities of novel oxapenems, alone and in combination with ceftazidime, against gram-positive and gram-negative organisms.
score: 1.3939986, Antimicrobial agents and chemotherapy, 2003, Jamieson, Conor E; Lambert, Peter A; Simpson, Iain N
The high affinity melatonin binding site probed with conformationally restricted ligands—II. Homology modeling of the receptor
score: 1.3939629, Bioorganic & Medicinal Chemistry, 1996, Grol, Cor J.; Jansen, Johanna M.
3′- N-Alkylamino-3′-deoxy- ara-uridines: A new class of potential inhibitors of ribonuclease A and angiogenin
score: 1.393857, Bioorganic & Medicinal Chemistry, 2006, Maiti, Tushar K. et. al.
ANN multiplexing model of drugs effect on macrophages; theoretical and flow cytometry study on the cytotoxicity of the anti-microbial drug G1 in spleen
score: 1.393852, Bioorganic & Medicinal Chemistry, 2012, Tenorio-Borroto, Esvieta et. al.
Synthesis and structure–activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects
score: 1.3937562, Bioorganic & Medicinal Chemistry, 2003, Isobe, Yoshiaki et. al.
Total synthesis of (+)-crocacin C
score: 1.3937063, Bioorganic & Medicinal Chemistry, 2010, Sirasani, Gopal; Paul, Tapas; Andrade, Rodrigo B.
Antibacterial properties of some cyclic organobismuth(III) compounds.
score: 1.3937026, Antimicrobial agents and chemotherapy, 2005, Kotani, Toshiaki et. al.
A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.
score: 1.3935623, Antimicrobial agents and chemotherapy, 2002, Jackowski, Suzanne et. al.
Reactions of 7- and 9-aminoadenines with 2,4-pentanedione. Formation of new ring systems, pyridazino[6,1- f]purine and pyridazino[1,6- e]purine
score: 1.3935458, Bioorganic & Medicinal Chemistry Letters, 1998, Kaiya, Toyo; Saga, Tetsuya; Yamagata, Yuriko; Kohda, Kohfuku
Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation
score: 1.3935413, Bioorganic & Medicinal Chemistry, 2006, Hosoda, Shinnosuke et. al.
A new class of bioactivable self-immolative N,O-ligands
score: 1.3934547, European Journal of Medicinal Chemistry, 2012, Kuźnik, Nikodem et. al.
Design, synthesis and evaluation of N-(substituted benzothiazol-2-yl)amides as anticonvulsant and neuroprotective
score: 1.3933982, European Journal of Medicinal Chemistry, 2012, Hassan, Mohd. Zaheen; Khan, Suroor A.; Amir, Mohd.
Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription.
score: 1.3933731, Antimicrobial agents and chemotherapy, 2004, Kutsch, Olaf et. al.
Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants
score: 1.393034, Bioorganic & Medicinal Chemistry Letters, 2007, Notter, Robert H. et. al.
Intact glycation end products containing carboxymethyl-lysine and glyoxal lysine dimer obtained from synthetic collagen model peptide
score: 1.3930224, Bioorganic & Medicinal Chemistry Letters, 2004, Yamada, Hiroaki et. al.
Tailoring structure–function and targeting properties of ceramides by site-specific cationization
score: 1.3928603, Bioorganic & Medicinal Chemistry, 2006, Szulc, Zdzislaw M. et. al.
The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica.
score: 1.3927196, Antimicrobial agents and chemotherapy, 2011, Circello, Benjamin T et. al.
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities
score: 1.3925459, Bioorganic & Medicinal Chemistry, 2005, Thomas, Brian F. et. al.
Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
score: 1.3925432, Antimicrobial agents and chemotherapy, 1999, Ma, L et. al.
Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/ glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides
score: 1.3923429, Bioorganic & Medicinal Chemistry Letters, 2012, Stokes, Suzanne S. et. al.
Use of ionically tagged glycosyl donors in the synthesis of oligosaccharide libraries
score: 1.3922207, Bioorganic & Medicinal Chemistry Letters, 2009, Kim, Eun Ju; Gray, Gary R.
Pharmacodynamics of a novel des-F(6)-quinolone, BMS-284756, against Streptococcus pneumoniae in the thigh infection model.
score: 1.3921197, Antimicrobial agents and chemotherapy, 2003, Nicolau, David P et. al.
Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.
score: 1.3921176, Bioorganic & Medicinal Chemistry, 2006, Anuradha, V. et. al.
Evaluation of nitroalkenes as nitric oxide donors
score: 1.3920749, Bioorganic & Medicinal Chemistry Letters, 2007, Gorczynski, Michael J. et. al.
Syntheses of 3-Ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: enzyme inhibition and effects on plasma lipid levels
score: 1.3918599, Bioorganic & Medicinal Chemistry, 2003, Ishihara, Tsukasa et. al.
Synthesis, radiosynthesis and in vivo preliminary evaluation of [ 11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET
score: 1.3915384, Bioorganic & Medicinal Chemistry, 2006, Dollé, Frédéric et. al.
Ester and carbamate ester derivatives of Biochanin A: Synthesis and in vitro evaluation of estrogenic and antiproliferative activities
score: 1.3915038, Bioorganic & Medicinal Chemistry, 2012, Fokialakis, Nikolas et. al.
Ester and carbamate ester derivatives of Biochanin A: Synthesis and in vitro evaluation of estrogenic and antiproliferative activities
score: 1.3915038, Bioorganic & Medicinal Chemistry, 2012, Fokialakis, Nikolas et. al.
Ligand Discovery from a Dopamine D 3 Receptor Homology Model and Crystal Structure
score: 1.391442, Nature Chemical Biology, 2011, Carlsson, Jens et. al.
Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics
score: 1.3914077, Bioorganic & Medicinal Chemistry, 2005, Lorente, Silvia Orenes et. al.
Bridge-linked bis-quaternary ammonium anti-microbial agents: relationship between cytotoxicity and anti-bacterial activity of 5,5′-[2,2′-(tetramethylenedicarbonyldioxy)-diethyl]bis(3-alkyl-4-methylthiazonium iodide)s
score: 1.3913454, Bioorganic & Medicinal Chemistry, 2005, Ohkura, Kazuto et. al.
Synthesis and biological evaluation of novel thioapio dideoxynucleosides
score: 1.3913058, Bioorganic & Medicinal Chemistry, 2002, Moon, Hyung Ryong et. al.
Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum.
score: 1.391205, Antimicrobial agents and chemotherapy, 2012, Vale-Costa, Sílvia et. al.
[ 68Ga]Ga-DO 2A-(OBu- l -tyr) 2: Synthesis, 68Ga-radiolabeling and in vitro studies of a novel 68Ga-DO 2A-tyrosine conjugate as potential tumor tracer for PET
score: 1.3911216, Bioorganic & Medicinal Chemistry Letters, 2009, Burchardt, Carsten et. al.
Utilizing the intramolecular Fukuyama–Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for peptidomimetic drug design
score: 1.3910315, Bioorganic & Medicinal Chemistry Letters, 2005, Zapf, Christoph W.; Del Valle, Juan R.; Goodman, Murray
1-Phenylpyrazolo[3,4- d]pyrimidines; structure–activity relationships for C6 substituents at A 1 and A 2A adenosine receptors
score: 1.3909098, Bioorganic & Medicinal Chemistry, 2000, Chebib, Mary; McKeveney, Declan; Quinn, Ronald J.
2D Autocorrelation modeling of the negative inotropic activity of calcium entry blockers using Bayesian-regularized genetic neural networks
score: 1.3907481, Bioorganic & Medicinal Chemistry, 2006, Caballero, Julio; Garriga, Miguel; Fernández, Michael
Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1
score: 1.3906726, European Journal of Medicinal Chemistry, 2012, Ventosa-Andrés, Pilar et. al.
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction
score: 1.390665, Bioorganic & Medicinal Chemistry, 2004, Jennings, Lee D. et. al.
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis
score: 1.3906356, Bioorganic & Medicinal Chemistry, 2006, Huang, Xiaoqin et. al.
Solution-phase combinatorial synthesis of ureas using nitrophenylcarbamates
score: 1.39035, Bioorganic & Medicinal Chemistry Letters, 1998, Raju, B.; Kassir, Jamal M.; Kogan, Timothy P.
N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers
score: 1.3903199, Bioorganic & Medicinal Chemistry, 2002, Liang, Pi-Hui; Hsin, Ling-Wei; Cheng, Chen-Yu
Development of acetaminophen proline prodrug
score: 1.3902801, Bioorganic & Medicinal Chemistry Letters, 2010, Wu, Zhiqian; Patel, Ashish; Dave, Rutesh; Yuan, Xudong
A new approach to the synthesis of polyunsaturated deuterated isoprostanes: Total synthesis of d 4-5- epi-8,12- iso-iPF 3α-VI and d 4-8,12- iso-iPF 3α-VI
score: 1.3902442, Bioorganic & Medicinal Chemistry Letters, 2009, Chang, Chih-Tsung et. al.
Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties
score: 1.3902399, European Journal of Medicinal Chemistry, 2012, Das, Swagatika et. al.
Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-Position. Part II: Synthesis and antibacterial activity of 3-(5-Methylthiazolo[4,5- c]pyridinium-2-yl)thiomethylcephalosporin derivatives and related compounds
score: 1.3901529, Bioorganic & Medicinal Chemistry, 1998, Tsushima, Masaki et. al.
Efficacy of NZ2114, a novel plectasin-derived cationic antimicrobial peptide antibiotic, in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
score: 1.3901492, Antimicrobial agents and chemotherapy, 2011, Xiong, Yan Q et. al.
Nucleosides with self-complementary hydrogen-bonding motifs: Synthesis and base-pairing studies of two nucleosides containing the imidazo[4,5- d]pyridazine ring system
score: 1.390098, Bioorganic & Medicinal Chemistry, 2006, Ujjinamatada, Ravi K. et. al.
Energetic effects for observed and unobserved HIV-1 reverse transcriptase mutations of residues L100, V106, and Y181 in the presence of nevirapine and efavirenz
score: 1.3900253, Bioorganic & Medicinal Chemistry Letters, 2008, Kroeger Smith, Marilyn B. et. al.
New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production
score: 1.3899147, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Jing et. al.
New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production
score: 1.3899147, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Jing et. al.
New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production
score: 1.3899147, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Jing et. al.
A plausible role of salivary copper in antimicrobial activity of histatin-5 —Metal binding and oxidative activity of its copper complex
score: 1.3898448, Bioorganic & Medicinal Chemistry Letters, 2009, Tay, William M. et. al.
Synthesis and Antirheumatic Activity of the Metabolites of Esonarimod
score: 1.3897566, Bioorganic & Medicinal Chemistry, 2002, Noguchi, Toshiya et. al.
Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies
score: 1.3897546, Bioorganic & Medicinal Chemistry Letters, 2010, Greene, Nigel et. al.
Liver cell specific targeting of peptide nucleic acid oligomers
score: 1.3897263, Bioorganic & Medicinal Chemistry Letters, 2001, Zhang, Xiao; Simmons, Carla G; Corey, David R
From SAR to comparative QSAR: role of hydrophobicity in the design of 4-hydroxy-5,6-dihydropyran-2-ones HIV-1 protease inhibitors
score: 1.3897025, Bioorganic & Medicinal Chemistry, 2005, Bhhatarai, Barun; Garg, Rajni
Trypsin resistance of a decapeptide KISS1R agonist containing an Nω-methylarginine substitution
score: 1.3896778, Bioorganic & Medicinal Chemistry Letters, 2012, Asami, Taiji et. al.
A structure–activity study of nociceptin-(1–13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10
score: 1.3895354, European Journal of Medicinal Chemistry, 2003, Bobrova, Irina et. al.
1,3-Dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase [1]
score: 1.3894245, Bioorganic & Medicinal Chemistry, 1999, Grunewald, Gary L. et. al.
Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl)
score: 1.3893175, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Sai-Yang et. al.
Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl)
score: 1.3893175, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Sai-Yang et. al.
Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives
score: 1.3892109, European Journal of Medicinal Chemistry, 2012, Hernández-Covarrubias, Carlos et. al.
Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity
score: 1.3890554, Bioorganic & Medicinal Chemistry, 2005, Kvasnica, Miroslav et. al.
Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone
score: 1.3890435, Bioorganic & Medicinal Chemistry Letters, 1998, Lin, Peishan; Ganesan, A.
Specificity of human trans-sialidase as probed with gangliosides
score: 1.3889291, Bioorganic & Medicinal Chemistry Letters, 2004, Nikonova, E.Yu. et. al.
Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl)
score: 1.3889062, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Sai-Yang et. al.
Synthesis and biological evaluation of new dipyrrolo[3,4- a:3,4- c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions
score: 1.3887125, Bioorganic & Medicinal Chemistry, 2006, Hénon, Hélène et. al.
β-Cyclodextrin/epoxysuccinyl peptide conjugates: a new drug targeting system for tumor cells
score: 1.388697, Bioorganic & Medicinal Chemistry Letters, 2000, Schaschke, Norbert et. al.
Synthesis Pharmacological Evaluation and Docking Studies of Pyrimidine Derivatives
score: 1.3886303, European Journal of Medicinal Chemistry, 2012, Giles, D. et. al.
Non-thiol farnesyltransferase inhibitors: structure–activity relationships of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors
score: 1.3885533, Bioorganic & Medicinal Chemistry, 2002, Schlitzer, Martin; Böhm, Markus; Sattler, Isabel
N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’
score: 1.3885336, Bioorganic & Medicinal Chemistry, 2004, Lee, Jeewoo et. al.
A new ligand binding to G–G mismatch having improved thermal and alkaline stability
score: 1.3885107, Bioorganic & Medicinal Chemistry Letters, 2005, Peng, Tao et. al.
Effects of azithromycin in combination with vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on Staphylococcus epidermidis biofilms.
score: 1.3883236, Antimicrobial agents and chemotherapy, 2009, Presterl, Elisabeth et. al.
Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone
score: 1.388267, Bioorganic & Medicinal Chemistry, 2003, Fossa, Paola et. al.
Synthesis and evaluation of peptidomimetics that bind DNA
score: 1.3881638, Bioorganic & Medicinal Chemistry, 2003, Turk, Jeffrey A; Smithrud, David B
Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis
score: 1.3879523, Bioorganic & Medicinal Chemistry, 2004, Wang, Jinhua et. al.
Anti-Malarial activity of N 6-Substituted adenosine derivatives. Part I
score: 1.3876634, Bioorganic & Medicinal Chemistry, 2002, Golisade, Abolfasl et. al.
Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers
score: 1.3874018, Bioorganic & Medicinal Chemistry Letters, 2012, Séro, Luc et. al.
Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers
score: 1.3874018, Bioorganic & Medicinal Chemistry Letters, 2012, Séro, Luc et. al.
Synthesis of symmetrical thiol-adenosine conjugate and 5′ thiol-RNA preparation by efficient one-step transcription
score: 1.3873924, Bioorganic & Medicinal Chemistry Letters, 2010, Huang, Faqing; Shi, Yongliang
Structure–activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling
score: 1.3871737, Bioorganic & Medicinal Chemistry, 2013, Lee, Ill-Young et. al.
Enantioselective synthesis of (+)-4-Demethoxy-1,4-Dimethyldaunomycinone
score: 1.3871183, Bioorganic & Medicinal Chemistry, 2002, Kotha, Sambasivarao; Stoodley, Richard J.
Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure–activity, spectroscopic, and computational studies
score: 1.3871024, Bioorganic & Medicinal Chemistry, 1999, Ceruso, Marco A. et. al.
Synthesis of linear-B saccharopeptides via enzymatic galactosylation of non-natural glucosamide acceptors
score: 1.3870488, Bioorganic & Medicinal Chemistry, 2001, Schwardt, Oliver; Baisch, Gabi; Öhrlein, Reinhold
In vitro activity of TD-6424 against Staphylococcus aureus.
score: 1.3868535, Antimicrobial agents and chemotherapy, 2003, Pace, John L et. al.
New cytotoxic furoquinones obtained from terpenyl-1,4-naphthoquinones and 1,4-anthracenediones
score: 1.3866296, Bioorganic & Medicinal Chemistry, 2006, Miguel del Corral, José M. et. al.
Synthesis, cytotoxicity, and DNA-topoisomerase inhibitory activity of new asymmetric ureas and thioureas
score: 1.3865338, Bioorganic & Medicinal Chemistry, 2006, Esteves-Souza, Andressa et. al.
Crystallographic and NMR studies of antiinfective tricyclic guanidine alkaloids from the sponge Monanchora unguifera
score: 1.3865231, Bioorganic & Medicinal Chemistry, 2004, Hua, Hui-ming et. al.
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds
score: 1.38652, European Journal of Medicinal Chemistry, 2002, Dimmock, Jonathan R et. al.
Absolute configurations of isoflavan-4-ol stereoisomers
score: 1.3863151, Bioorganic & Medicinal Chemistry Letters, 2008, Won, Dongho et. al.
Novel bidentate complexes of Cu(II) derived from 5-nitrofuran-2-carboxaldehyde thiosemicarbazones with antiamoebic activity against E. histolytica
score: 1.3862257, European Journal of Medicinal Chemistry, 2005, Sharma, Sangita et. al.
Structure-based design of non-peptide, carbohydrazide-based cathepsin K inhibitors
score: 1.3862202, Bioorganic & Medicinal Chemistry, 1999, Thompson, Scott K et. al.
QSAR studies on psychotomimetic phenylalkylamines
score: 1.3860891, Bioorganic & Medicinal Chemistry, 2004, Thakur, Mamta; Thakur, Abhilash; Khadikar, Padmakar V.
Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons
score: 1.386045, Bioorganic & Medicinal Chemistry, 2012, Matsuya, Yuji et. al.
Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue
score: 1.3860097, Bioorganic & Medicinal Chemistry, 2002, Damen, Eric W.P. et. al.
Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis
score: 1.38583, Bioorganic & Medicinal Chemistry, 2013, Csuk, René et. al.
Synthesis and biochemical properties of Z- and E-4,5-dehydrodethiobiotin
score: 1.38581, Bioorganic & Medicinal Chemistry, 1996, Jestin, Eric et. al.
Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens
score: 1.385671, Bioorganic & Medicinal Chemistry, 2012, Shi, Qian et. al.
Crystal structure of the mobile metallo-β-lactamase AIM-1 from Pseudomonas aeruginosa: insights into antibiotic binding and the role of Gln157.
score: 1.3856662, Antimicrobial agents and chemotherapy, 2012, Leiros, Hanna-Kirsti S et. al.
Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity
score: 1.3856488, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Zhi Kai et. al.
Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity
score: 1.3856488, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Zhi Kai et. al.
Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity
score: 1.3856488, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Zhi Kai et. al.
Artemisinin and a series of novel endoperoxide antimalarials exert early effects on digestive vacuole morphology.
score: 1.3853375, Antimicrobial agents and chemotherapy, 2008, del Pilar Crespo, Maria et. al.
High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization
score: 1.3852605, Bioorganic & Medicinal Chemistry Letters, 2005, Zhou, Tao et. al.
In vitro growth inhibition of human cancer cells by novel honokiol analogs
score: 1.3851999, Bioorganic & Medicinal Chemistry, 2012, Lin, Jyh Ming et. al.
In vitro growth inhibition of human cancer cells by novel honokiol analogs
score: 1.3851999, Bioorganic & Medicinal Chemistry, 2012, Lin, Jyh Ming et. al.
Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro.
score: 1.3850035, Antimicrobial agents and chemotherapy, 2002, Delmas, Julien et. al.
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammation agents
score: 1.3846653, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Wukun et. al.
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents
score: 1.3846653, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Wukun et. al.
Development of a new enzyme-responsive self-immolative spacer conjugate applicable to the controlled drug release
score: 1.3846058, Bioorganic & Medicinal Chemistry, 2012, Jin, Hui-juan; Lu, Jing; Wu, Xue
Development of a new enzyme-responsive self-immolative spacer conjugate applicable to the controlled drug release
score: 1.3846058, Bioorganic & Medicinal Chemistry, 2012, Jin, Hui-juan; Lu, Jing; Wu, Xue
Development of a new enzyme-responsive self-immolative spacer conjugate applicable to the controlled drug release
score: 1.3846058, Bioorganic & Medicinal Chemistry, 2012, Jin, Hui-juan; Lu, Jing; Wu, Xue
Synthesis, antiviral and contraceptive activities of nucleoside–sodium cellulose sulfate acetate and succinate conjugates
score: 1.3845738, Bioorganic & Medicinal Chemistry Letters, 2010, Agarwal, Hitesh K. et. al.
New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro
score: 1.3845389, Bioorganic & Medicinal Chemistry, 2006, Ueda, Jun-ya et. al.
N-Caffeoyl serotonin as selective COX-2 inhibitor
score: 1.3845133, Bioorganic & Medicinal Chemistry Letters, 2012, Takahashi, Toshiyuki; Miyazawa, Mitsuo
Synthesis and biological evaluation of new non-imidazole H 3-receptor antagonists of the 2-aminobenzimidazole series
score: 1.3844382, Bioorganic & Medicinal Chemistry, 2006, Rivara, Mirko et. al.
Combinatorial mixture synthesis and biological evaluation of dihydrophenyl triazine antifolates
score: 1.384429, Bioorganic & Medicinal Chemistry, 1999, Lee, Hong-Kee; Chui, Wai-Keung
Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs
score: 1.3843614, Bioorganic & Medicinal Chemistry, 2012, Nandurdikar, Rahul S. et. al.
Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs
score: 1.3843614, Bioorganic & Medicinal Chemistry, 2012, Nandurdikar, Rahul S. et. al.
Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents
score: 1.3842947, Bioorganic & Medicinal Chemistry, 2004, Abdel-Rahman, A.H.; Keshk, E.M.; Hanna, M.A.; El-Bady, Sh.M.
Estrogen pyrazoles: defining the pyrazole core structure and the orientation of substituents in the ligand binding pocket of the estrogen receptor
score: 1.3841745, Bioorganic & Medicinal Chemistry, 2001, Stauffer, Shaun R et. al.
The posttranslocational chaperone lipoprotein PrsA is involved in both glycopeptide and oxacillin resistance in Staphylococcus aureus.
score: 1.3841618, Antimicrobial agents and chemotherapy, 2012, Jousselin, Ambre et. al.
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
score: 1.3839074, Bioorganic & Medicinal Chemistry, 2012, Su, Li et. al.
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
score: 1.3839074, Bioorganic & Medicinal Chemistry, 2012, Su, Li et. al.
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
score: 1.3839074, Bioorganic & Medicinal Chemistry, 2012, Su, Li et. al.
A novel type of fluorescent boronic acid that shows large fluorescence intensity changes upon binding with a carbohydrate in aqueous solution at physiological pH
score: 1.3838997, Bioorganic & Medicinal Chemistry Letters, 2003, Yang, Wenqian et. al.
QSAR studies on 1-phenylbenzimidazoles as inhibitors of the platelet-derived growth factor
score: 1.3838577, Bioorganic & Medicinal Chemistry, 2005, Katritzky, Alan R. et. al.
Glucose uptake stimulatory effect of 4-hydroxypipecolic acid by increased GLUT 4 translocation in skeletal muscle cells
score: 1.3838509, Bioorganic & Medicinal Chemistry Letters, 2012, Naresh, G. et. al.
Antitumor agents 216. Synthesis and evaluation of paclitaxel–camptothecin conjugates as novel cytotoxic agents 1
score: 1.3838322, Bioorganic & Medicinal Chemistry, 2003, Ohtsu, Hironori et. al.
Transcription inhibition using modified pentanucleotides
score: 1.3838075, Bioorganic & Medicinal Chemistry, 2003, Hwang, Jae-Taeg et. al.
Design, structural and spectroscopic elucidation, and the in vitro biological activities of new diorganotin dithiocarbamates
score: 1.3835858, European Journal of Medicinal Chemistry, 2012, Ferreira, Isabella P. et. al.
On the preparative use of recombinant pig α(1–3)galactosyl-transferase
score: 1.3833163, Bioorganic & Medicinal Chemistry Letters, 1998, Baisch, Gabi et. al.
QSAR by LFER model of cytotoxicity data of anti-HIV 5-phenyl-1-phenylamino-1 H-imidazole derivatives using principal component factor analysis and genetic function approximation
score: 1.3831787, Bioorganic & Medicinal Chemistry, 2005, Roy, Kunal; Leonard, J. Thomas
A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes
score: 1.3829856, Bioorganic & Medicinal Chemistry Letters, 2012, Pham, The Hien et. al.
Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents
score: 1.3829265, Bioorganic & Medicinal Chemistry, 2002, Xu, Guozhang et. al.
Design and synthesis of a β-amino phosphotyrosyl mimetic suitably protected for peptide synthesis
score: 1.3825762, Bioorganic & Medicinal Chemistry Letters, 2002, Lee, Kyeong; Zhang, Manchao; Yang, Dajun; Burke, Terrence R
Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2
score: 1.3824861, Bioorganic & Medicinal Chemistry, 2006, Jiang, Yu Lin et. al.
An improved synthesis of α,β-unsaturated nitrones relevant to the stephacidins and analogs thereof
score: 1.3824446, Bioorganic & Medicinal Chemistry Letters, 2009, Hafensteiner, Benjamin D. et. al.
Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity
score: 1.3824315, Bioorganic & Medicinal Chemistry, 2006, Gul, Waseem et. al.
Synthesis and antifilarial evaluation of N 1 ,N n - xylofuranosylated diaminoalkanes
score: 1.3823982, Bioorganic & Medicinal Chemistry, 2003, Tiwari, V.K et. al.
Synthesis and study of cyclic pronucleotides of 5-fluoro-2′-deoxyuridine
score: 1.3822576, Bioorganic & Medicinal Chemistry Letters, 2012, Jain, Harsh V.; Kalman, Thomas I.
Nick-containing oligonucleotides as human topoisomerase I inhibitors
score: 1.3822161, Bioorganic & Medicinal Chemistry Letters, 2009, Chua, Sock Teng et. al.
Regioselective hydrolysis of peracetylated α-D-glucopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis
score: 1.3822119, Bioorganic & Medicinal Chemistry Letters, 1999, Bastida, Agatha et. al.
1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) and related derivatives: chemistry and biochemical effects on catecholamine biosynthesis
score: 1.3821983, Bioorganic & Medicinal Chemistry, 2002, Bringmann, Gerhard et. al.
Production of truncated protein by the crosslink formation of mRNA with 2’-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
score: 1.3817698, Bioorganic & Medicinal Chemistry Letters, 2012, Hagihara, Shinya et. al.
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors
score: 1.3817333, European Journal of Medicinal Chemistry, 2013, Helguera, Aliuska Morales et. al.
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors
score: 1.3817333, European Journal of Medicinal Chemistry, 2013, Helguera, Aliuska Morales et. al.
Dolastatin 11 conformations, analogues and pharmacophore
score: 1.3817185, Bioorganic & Medicinal Chemistry, 2005, Ali, Md. Ahad et. al.
Synthesis and Antibiofilm Activity of Marine Natural Product-Based 4-Thiazolidinones Derivatives
score: 1.3817101, Bioorganic & Medicinal Chemistry Letters, 2012, Rane, Rajesh A.; Sahu, Niteshkumar U.; Shah, Chetan P.
Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients
score: 1.3816925, Bioorganic & Medicinal Chemistry Letters, 2010, Rak, Jakub; Kaplánek, Robert; Král, Vladimír
Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics.
score: 1.3816345, Antimicrobial agents and chemotherapy, 2012, McGillivray, Shauna M et. al.
Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry
score: 1.3816077, European Journal of Medicinal Chemistry, 2012, Zhang, Yikai et. al.
[ 3H]8-Ethyl-4-methyl-2-phenyl-(8 R)-4,5,7,8-tetrahydro-1 H-imidazo[2,1- i]-purin-5-one ([ 3H]PSB-11), a Novel High-Affinity Antagonist Radioligand for Human A 3 Adenosine Receptors
score: 1.3814682, Bioorganic & Medicinal Chemistry Letters, 2002, Müller, Christa E. et. al.
Aptamers containing thymidine 3′-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB
score: 1.3814172, Bioorganic & Medicinal Chemistry Letters, 1999, Yang, Xianbin et. al.
Combined NMR and molecular modeling study of an iduronic acid-containing trisaccharide related to antithrombotic heparin fragments
score: 1.3814093, Bioorganic & Medicinal Chemistry, 1997, Cros, Soizic et. al.
Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist
score: 1.381397, Bioorganic & Medicinal Chemistry Letters, 2012, Epifano, Francesco et. al.
Tetrapeptides as potent protease inhibitors of hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase)
score: 1.3813938, Bioorganic & Medicinal Chemistry, 2002, Johansson, Anja et. al.
Synthesis and Biological Evaluation of MAO-A Selective 1,4-Disubstituted-1,2,3,6-tetrahydropyridinyl Substrates
score: 1.3812961, Bioorganic & Medicinal Chemistry, 2002, Bissel, Philippe et. al.
In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum.
score: 1.3812588, Antimicrobial agents and chemotherapy, 2011, Jordão, Fabiana Morandi et. al.
Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells
score: 1.3812273, European Journal of Medicinal Chemistry, 2012, Khelili, Smail et. al.
Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells
score: 1.3812273, European Journal of Medicinal Chemistry, 2012, Khelili, Smail et. al.
In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication.
score: 1.3812237, Antimicrobial agents and chemotherapy, 2005, Kern, Earl R et. al.
Griffithsin has antiviral activity against hepatitis C virus.
score: 1.3812091, Antimicrobial agents and chemotherapy, 2011, Meuleman, Philip et. al.
Loss of antagonistic activity of tamoxifen by replacement of one N-methyl of its side chain by fluorinated residues
score: 1.3811444, Bioorganic & Medicinal Chemistry, 2006, Agouridas, Vangelis et. al.
Oligomers of glycamino acid
score: 1.3811138, Bioorganic & Medicinal Chemistry, 2002, Suhara, Yoshitomo et. al.
Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells
score: 1.3811081, European Journal of Medicinal Chemistry, 2013, Li, Dahong et. al.
Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells
score: 1.3811081, European Journal of Medicinal Chemistry, 2013, Li, Dahong et. al.
Synthesis of β-lactam nucleoside chimera via Kinugasa reaction and evaluation of their antibacterial activity
score: 1.3810272, Bioorganic & Medicinal Chemistry Letters, 2005, Basak, Amit; Pal, Runa
Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum
score: 1.381017, Bioorganic & Medicinal Chemistry Letters, 2012, Sugiura, Reiko et. al.
Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum
score: 1.381017, Bioorganic & Medicinal Chemistry Letters, 2012, Sugiura, Reiko et. al.
Synthesis, characterization and antimicrobial activity of some substituted 1,2,3-triazoles
score: 1.3809633, European Journal of Medicinal Chemistry, 2005, Holla, Bantwal Shivarama et. al.
Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques.
score: 1.3809554, Antimicrobial agents and chemotherapy, 2012, Malcolm, R Karl et. al.
Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ET A receptor radioligands
score: 1.3809197, Bioorganic & Medicinal Chemistry, 2006, Höltke, Carsten et. al.
Potential antitumor agents. part 29 1: synthesis and potential coanthracyclinic activity of Imidazo[2,1-b]thiazole guanylhydrazones
score: 1.3808717, Bioorganic & Medicinal Chemistry, 2000, Andreani, Aldo et. al.
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13
score: 1.3808524, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Mi-Sun et. al.
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13
score: 1.3808524, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Mi-Sun et. al.
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13
score: 1.3808524, Bioorganic & Medicinal Chemistry Letters, 2012, Yu, Mi-Sun et. al.
Selective photolabeling of Lck kinase in complex proteome
score: 1.3807641, Bioorganic & Medicinal Chemistry Letters, 2006, Hindi, Sagit et. al.
Design of peptides derived from anti-IgE antibody for allergic treatment
score: 1.3807257, Bioorganic & Medicinal Chemistry Letters, 1999, Takahashi, Mizuki et. al.
In vitro and in vivo studies of the utility of dimethyl and diethyl carbaporphyrin ketals in treatment of cutaneous leishmaniasis.
score: 1.3806141, Antimicrobial agents and chemotherapy, 2011, Taylor, Viviana M et. al.
Functionalized nucleoside 5′-triphosphates for in vitro selection of new catalytic ribonucleic acids
score: 1.3805691, Bioorganic & Medicinal Chemistry Letters, 2000, Matulic-Adamic, Jasenka et. al.
Towards the identification of unknown neuropeptide precursor-processing enzymes: Design and synthesis of a new family of dipeptidyl phosphonate activity probes for substrate-based protease identification
score: 1.3805261, Bioorganic & Medicinal Chemistry, 2010, Sabidó, Eduard; Tarragó, Teresa; Giralt, Ernest
Synthesis and neuroprotective activity of analogues of glycyl- l-prolyl- l-glutamic acid (GPE) modified at the α-carboxylic acid
score: 1.3804082, Bioorganic & Medicinal Chemistry, 2005, Trotter, Nicholas S. et. al.
Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479.
score: 1.3802986, Antimicrobial agents and chemotherapy, 2008, Ali, Samir et. al.
Microfluidic technology: An economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET)
score: 1.3801671, Bioorganic & Medicinal Chemistry Letters, 2012, Bouvet, Vincent et. al.
Xylo-Configured oligonucleotides (XNA, xylo nucleic acid): synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements
score: 1.3801623, Bioorganic & Medicinal Chemistry Letters, 2003, Poopeiko, Nicolai E. et. al.
Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers
score: 1.3800139, Bioorganic & Medicinal Chemistry Letters, 1998, Dreef-Tromp, C.M. et. al.
Lincomycin and clindamycin conformations. A fragment shared by macrolides, ketolides and lincosamides determined from TRNOE ribosome-bound conformations
score: 1.3800105, Bioorganic & Medicinal Chemistry, 2000, Verdier, Laurent et. al.
Synthesis and antibacterial activities of new 1β-methylcarbapenems having aminopyrimidinylthioether moiety
score: 1.3799574, European Journal of Medicinal Chemistry, 2006, Lee, K.S. et. al.
The anticonvulsant activities of N-benzyl 3-methoxypropionamides
score: 1.3799523, Bioorganic & Medicinal Chemistry, 1999, Andurkar, Shridhar V.; Stables, James P.; Kohn, Harold
Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones
score: 1.3798444, European Journal of Medicinal Chemistry, 2005, Balasubramanian, S. et. al.
QSAR Study on Some p-Arylthio Cinnamides as Antagonists of Biochemical ICAM-1/LFA-1 Interaction and ICAM-1/JY-8 Cell Adhesion in Relation to Anti-inflammatory Activity
score: 1.3795973, Bioorganic & Medicinal Chemistry, 2003, Debnath, Bikash; Samanta, Soma; Roy, Kunal; Jha, Tarun
In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi.
score: 1.3794171, Antimicrobial agents and chemotherapy, 2000, Urbina, J A; Lira, R; Visbal, G; Bartrolí, J
Pharmacodynamics of the new fluoroquinolone gatifloxacin in murine thigh and lung infection models.
score: 1.3793859, Antimicrobial agents and chemotherapy, 2002, Andes, D; Craig, W A
Conserved water molecules stabilize the Omega-loop in class A beta-lactamases.
score: 1.3793777, Antimicrobial agents and chemotherapy, 2008, Bös, Fabian; Pleiss, Jürgen
Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains.
score: 1.3793386, Antimicrobial agents and chemotherapy, 2011, Schanzer, Jürgen et. al.
Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures.
score: 1.3793062, Antimicrobial agents and chemotherapy, 2005, Dal Pozzo, F et. al.
High-affinity aptamers to subtype 3a hepatitis C virus polymerase display genotypic specificity.
score: 1.3792824, Antimicrobial agents and chemotherapy, 2006, Jones, Louisa A et. al.
Oxadiazole synthesis on solid supports
score: 1.3791163, Bioorganic & Medicinal Chemistry Letters, 1999, Liang, Gui-Bai; Qian, Xiaoxia
Novel Inhibitors of Heat Shock Protein Hsp70-Mediated Luciferase Refolding that Bind to DnaJ
score: 1.3790393, Bioorganic & Medicinal Chemistry, 2012, Cassel, Joel A. et. al.
Antimicrobial activity of euplotin C, the sesquiterpene taxonomic marker from the marine ciliate Euplotes crassus.
score: 1.3789374, Antimicrobial agents and chemotherapy, 2004, Savoia, Dianella et. al.
Evaluation of ceftobiprole activity against a variety of gram-negative pathogens, including Escherichia coli, Haemophilus influenzae (β-lactamase positive and β-lactamase negative), and Klebsiella pneumoniae, in a rabbit meningitis model.
score: 1.37891, Antimicrobial agents and chemotherapy, 2012, Stucki, A et. al.
Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors
score: 1.3788222, Bioorganic & Medicinal Chemistry, 1999, Eummer, Jeffrey T et. al.
Synthesis of [ 18F]SU11248, a new potential PET tracer for imaging cancer tyrosine kinase
score: 1.378792, Bioorganic & Medicinal Chemistry Letters, 2005, Wang, Ji-Quan et. al.
Efficient synthesis of lactosaminylated core-2 O-glycans
score: 1.3787307, Bioorganic & Medicinal Chemistry Letters, 2001, Misra, Anup Kumar; Fukuda, Minoru; Hindsgaul, Ole
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents
score: 1.3787091, European Journal of Medicinal Chemistry, 2012, Peng, Fei et. al.
Synthesis and chemiluminescent high throughput screening for inhibition of acetylcholinesterase activity by imidazo[2,1- b]thiazole derivatives
score: 1.3786697, European Journal of Medicinal Chemistry, 2005, Andreani, Aldo et. al.
In vitro activity and single-step mutational analysis of rifamycin SV tested against enteropathogens associated with traveler's diarrhea and Clostridium difficile.
score: 1.3786629, Antimicrobial agents and chemotherapy, 2011, Farrell, David J et. al.
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor
score: 1.378632, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Shang-Ke et. al.
Oligonucleotides containing 4′- C-aminomethyl-2′-modified thymidines show increased binding affinity towards DNA and RNA
score: 1.3785574, Bioorganic & Medicinal Chemistry Letters, 1999, Pfundheller, Henrik M.; Wengel, Jesper
Structural requirement of isoflavonones for the inhibitory activity of interleukin-5
score: 1.3784708, European Journal of Medicinal Chemistry, 2003, Jung, Sang-Hun et. al.
High-affinity and selective dopamine D3 receptor full agonists
score: 1.3784688, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jianyong; Levant, Beth; Wang, Shaomeng
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases
score: 1.3784502, Bioorganic & Medicinal Chemistry, 2005, Kim, Jin-Wook et. al.
Design, Synthesis and Pharmacological evaluation of 4-(Piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 Receptor Ligands
score: 1.3784368, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
Anti-Hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke ( Cynara scolymus L.): structure requirement and mode of action
score: 1.3780458, Bioorganic & Medicinal Chemistry Letters, 2003, Shimoda, Hiroshi et. al.
Cristatumins A–D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220
score: 1.3779855, Bioorganic & Medicinal Chemistry Letters, 2012, Du, Feng-Yu et. al.
Cristatumins A–D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220
score: 1.3779855, Bioorganic & Medicinal Chemistry Letters, 2012, Du, Feng-Yu et. al.
Renin inhibition activity by chitooligosaccharides
score: 1.3779685, Bioorganic & Medicinal Chemistry Letters, 2008, Park, Pyo-Jam; Ahn, Chang-Bum; Jeon, You-Jin; Je, Jae-Young
Applying Mosher's method to acetogenins bearing vicinal diols. The absolute configurations of muricatetrocin C and rollidecins A and B, new bioactive acetogenins from Rollinia mucosa
score: 1.3779582, Bioorganic & Medicinal Chemistry, 1996, Shi, Guoen et. al.
Synthesis and biological evaluation of C-3′NH/C-10 and C-2/C-10 modified paclitaxel analogues
score: 1.3778742, Bioorganic & Medicinal Chemistry, 2003, Baloglu, Erkan et. al.
Chemical synthesis of S-ribosyl- l-homocysteine and activity assay as a LuxS substrate
score: 1.3778335, Bioorganic & Medicinal Chemistry Letters, 2003, Zhao, Gang et. al.
In vitro interactions between aspirin and amphotericin B against planktonic cells and biofilm cells of Candida albicans and C. parapsilosis.
score: 1.3777762, Antimicrobial agents and chemotherapy, 2012, Zhou, Yabin et. al.
Inhibition of dipeptidyl peptidase IV (DPP IV) by 2-(2-amino-1-fluoro-propylidene)-cyclopentanecarbonitrile, a fluoroolefin containing peptidomimetic
score: 1.3777476, Bioorganic & Medicinal Chemistry, 2003, Zhao, Kake; Lim, Dong Sung; Funaki, Takashi; Welch, John T.
Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing mice
score: 1.3777293, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yong et. al.
Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing mice
score: 1.3777293, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Yong et. al.
Production of truncated protein by the crosslink formation of mRNA with 2′-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
score: 1.3777262, Bioorganic & Medicinal Chemistry Letters, 2012, Hagihara, Shinya et. al.
Production of truncated protein by the crosslink formation of mRNA with 2′-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
score: 1.3777262, Bioorganic & Medicinal Chemistry Letters, 2012, Hagihara, Shinya et. al.
Production of truncated protein by the crosslink formation of mRNA with 2′-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
score: 1.3777262, Bioorganic & Medicinal Chemistry Letters, 2012, Hagihara, Shinya et. al.
Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates
score: 1.3777152, Bioorganic & Medicinal Chemistry, 2008, Yang, Xin-Bin et. al.
15N NMR and electronic properties of S-nitrosothiols
score: 1.3776957, Bioorganic & Medicinal Chemistry Letters, 1999, Kun Wang, et. al.
4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replication.
score: 1.377609, Antimicrobial agents and chemotherapy, 2011, Vu, B Christie et. al.
Synthesis, photochemical synthesis, DNA binding and antitumor evaluation of novel cyano- and amidino-substituted derivatives of naphtho-furans, naphtho-thiophenes, thieno-benzofurans, benzo-dithiophenes and their acyclic precursors
score: 1.3773813, European Journal of Medicinal Chemistry, 2006, Starčević, Kristina et. al.
Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase
score: 1.3773649, Bioorganic & Medicinal Chemistry Letters, 2006, He, Weiguo; Wu, Jiaquan; Khosla, Chaitan; Cane, David E.
Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system.
score: 1.3772453, Antimicrobial agents and chemotherapy, 2000, Alksne, L E et. al.
Coumarin-based prodrugs. Part 3: Structural effects on the release kinetics of esterase-sensitive prodrugs of amines 1 1 Part of this work was performed at the University of Oklahoma Health Sciences Center, College of Pharmacy.
score: 1.3771655, Bioorganic & Medicinal Chemistry, 1998, Wang, Binghe; Zhang, Huijuan; Zheng, Ailian; Wang, Wei
Antibacterial and antifungal activities of new pyrazolo[3,4- d]pyridazin derivatives
score: 1.3769865, European Journal of Medicinal Chemistry, 2005, Akbas, Esvet; Berber, Ismet
Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues
score: 1.376984, Bioorganic & Medicinal Chemistry, 1996, Marek Golebiewski, W.; Keyes, Robert F.; Cushman, Mark
Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants
score: 1.3768394, Bioorganic & Medicinal Chemistry, 1999, Parmar, Virinder S et. al.
Synthesis, antimicrobial, and anti-HIV-1 activity of certain 5-(1-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminomethyl-1,3,4-oxadiazoline-2-thiones
score: 1.3767846, Bioorganic & Medicinal Chemistry, 2004, El-Emam, Ali A. et. al.
Novel fluorescent probe for detecting hydroperoxides with strong emission in the visible range
score: 1.3767571, Bioorganic & Medicinal Chemistry Letters, 2006, Soh, Nobuaki et. al.
Hypocrellin derivative with improvements of red absorption and active oxygen species generation
score: 1.376749, Bioorganic & Medicinal Chemistry Letters, 2004, Xu, Shangjie; Chen, Shen; Zhang, Manhua; Shen, Tao
Stereospecific synthesis and mass spectrometry of 5,6- trans-epoxy-8 Z,11 Z,14 Z-eicosatrienoic acid
score: 1.3766405, Bioorganic & Medicinal Chemistry Letters, 2005, Roy, Uzzal et. al.
Novel epoxide formation in the reaction of 2-bromo-3-methyl-1,4-naphthoquinone with 1,3-propanedithiol
score: 1.3765281, Bioorganic & Medicinal Chemistry Letters, 2010, Lam, Tom M. et. al.
Oxidative aromatization of 1,4-dihydropyridines and pyrazolines using HbA–H 2O 2: An efficient biomimetic catalyst system providing metabolites of drug candidates
score: 1.3765053, Bioorganic & Medicinal Chemistry Letters, 2009, Kumar, Atul; Maurya, Ram Awatar; Sharma, Siddharth
Synthesis and cytotoxic activity of 2-acyl-1 H-indole-4,7-diones on human cancer cell lines
score: 1.3764587, European Journal of Medicinal Chemistry, 2005, Mahboobi, Siavosh et. al.
Syntheses and antibacterial activity of a series of 3-(pyridine-3-yl)-2-oxazolidinone
score: 1.3763563, European Journal of Medicinal Chemistry, 2005, Cui, Yingjie et. al.
Pharmacodynamics of a new cephalosporin, PPI-0903 (TAK-599), active against methicillin-resistant Staphylococcus aureus in murine thigh and lung infection models: identification of an in vivo pharmacokinetic-pharmacodynamic target.
score: 1.3762808, Antimicrobial agents and chemotherapy, 2006, Andes, D; Craig, W A
Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids
score: 1.3761691, Bioorganic & Medicinal Chemistry, 2005, Coro, Julieta et. al.
A simple method for monitoring protein–DNA interactions
score: 1.3761598, Bioorganic & Medicinal Chemistry Letters, 2009, Fülöp, Annabelle et. al.
From a total synthesis of cepabactin and its 3:1 ferric complex to the isolation of a 1:1:1 mixed complex between iron (III), cepabactin and pyochelin
score: 1.3761492, Bioorganic & Medicinal Chemistry Letters, 2005, Klumpp, Cédric et. al.
Synthetic glycolipids for glioma growth inhibition developed from neurostatin and NF115 compound
score: 1.3760755, Bioorganic & Medicinal Chemistry Letters, 2013, Doncel-Pérez, Ernesto et. al.
Design, synthesis and structure–affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands
score: 1.3760268, Bioorganic & Medicinal Chemistry, 2004, Okubo, Taketoshi et. al.
An image contrast agent selectively activated by prostate specific antigen
score: 1.3757369, Bioorganic & Medicinal Chemistry, 2006, Jones, Graham B. et. al.
4-Alkylidene-azetidin-2-ones: novel inhibitors of leukocyte elastase and gelatinase
score: 1.3757096, Bioorganic & Medicinal Chemistry, 2003, Cainelli, Gianfranco et. al.
N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)
score: 1.3756008, Bioorganic & Medicinal Chemistry, 2012, Sabbah, Dima A. et. al.
N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)
score: 1.3756008, Bioorganic & Medicinal Chemistry, 2012, Sabbah, Dima A. et. al.
N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)
score: 1.3756008, Bioorganic & Medicinal Chemistry, 2012, Sabbah, Dima A. et. al.
Synthesis and cytotoxicity evaluation of 6,11-dihydro-pyridazo- and 6,11-dihydro-pyrido[2,3- b]phenazine-6,11-diones
score: 1.3754636, Bioorganic & Medicinal Chemistry, 2004, Lee, Hyun-Jung et. al.
Synthesis of multisubstituted quinolines from Baylis–Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity
score: 1.3753815, Bioorganic & Medicinal Chemistry, 2006, Narender, P. et. al.
Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor
score: 1.3753009, Bioorganic & Medicinal Chemistry, 2001, Matsumoto, Hikaru et. al.
Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.
score: 1.3752811, Antimicrobial agents and chemotherapy, 2003, Enanga, Bertin et. al.
Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.
score: 1.3752698, Antimicrobial agents and chemotherapy, 2002, Vakulenko, Sergei; Golemi, Dasantila
Development of a Purine-Scaffold Novel Class of Hsp90 Binders that Inhibit the Proliferation of Cancer Cells and Induce the Degradation of Her2 Tyrosine Kinase
score: 1.3751752, Bioorganic & Medicinal Chemistry, 2002, Chiosis, Gabriela et. al.
Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors
score: 1.3751301, Bioorganic & Medicinal Chemistry Letters, 2012, Scott, James S. et. al.
Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors
score: 1.3751301, Bioorganic & Medicinal Chemistry Letters, 2012, Scott, James S. et. al.
Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors
score: 1.3749731, European Journal of Medicinal Chemistry, 2012, Yao, Chun-Hsu et. al.
Inhibitors of Reactive Oxygen Species Accumulation Delay and/or Reduce the Lethality of Several Antistaphylococcal Agents.
score: 1.37496, Antimicrobial agents and chemotherapy, 2012, Liu, Yuanli et. al.
Synthesis of glycosylated β-Amino hydroxamates as new class of antimalarials
score: 1.3749072, Bioorganic & Medicinal Chemistry, 2003, Mishra, R.C. et. al.
The effects of ascorbic acid on homolytic processes involving α-hydroxyl-containing carbon-centered radicals
score: 1.374856, Bioorganic & Medicinal Chemistry Letters, 2008, Brinkevich, S.D.; Shadyro, O.I.
6-Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-onessubstituted with ibuprofen: synthesis, characterizationand evaluation of anti-inflammatory activity
score: 1.3748406, European Journal of Medicinal Chemistry, 2000, Tozkoparan, Birsen et. al.
Synthesis, resolution, and determination of the absolute configuration of the enantiomers of cis-4,5-dihydroxy-1,2-dithiane 1,1-dioxide, an HIV-1 NCp7 inhibitor
score: 1.3748167, Bioorganic & Medicinal Chemistry, 2003, Mayasundari, Anand et. al.
Novel 2-substituted nitronyl nitroxides as free radical scavengers: Synthesis, biological evaluation and structure–activity relationship
score: 1.3745886, Bioorganic & Medicinal Chemistry, 2006, Wu, Yihui et. al.
Synthesis and preliminary pharmacological evaluation of new (±) 1,4-naphthoquinones structurally related to lapachol
score: 1.3745783, Bioorganic & Medicinal Chemistry, 2002, da Silva, Alcides J.M et. al.
Synthetic and novel biocatalytic resolution studies on (±)-5/6/7-acetoxy-4-aryl-3,4-dihydrocoumarins
score: 1.3744457, Bioorganic & Medicinal Chemistry, 2003, Singh, Ishwar et. al.
Efficient synthesis of γ -DDB
score: 1.3743108, Bioorganic & Medicinal Chemistry Letters, 2004, Chang, Junbiao et. al.
Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists
score: 1.3742536, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II
score: 1.374153, Bioorganic & Medicinal Chemistry, 2012, Obniska, Jolanta; Rzepka, Sabina; Kamiński, Krzysztof
Synthesis and olfactoric activity of side-chain modified β-santalol analogues
score: 1.3741183, European Journal of Medicinal Chemistry, 2001, Buchbauer, Gerhard et. al.
Substituted Indoloquinolines as New Antifungal Agents
score: 1.3740566, Bioorganic & Medicinal Chemistry, 2002, Ablordeppey, Seth Y et. al.
Properties of analogues of an intermediate in the process of mechanism-based inactivation of carboxypeptidase A
score: 1.3739801, Bioorganic & Medicinal Chemistry, 1996, Ghosh, Soumitra S. et. al.
High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.
score: 1.373847, Antimicrobial agents and chemotherapy, 2001, Pérez-Victoria, J M et. al.
Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.
score: 1.3738003, Antimicrobial agents and chemotherapy, 2006, Wang, Feng; Cassidy, Craig; Sacchettini, James C
Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.
score: 1.3737915, Antimicrobial agents and chemotherapy, 2011, Aminake, Makoah N et. al.
Second-generation dimeric inhibitors of chitin synthase
score: 1.3737182, Bioorganic & Medicinal Chemistry, 2004, Yeager, Adam R.; Finney, Nathaniel S.
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities
score: 1.3736413, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Jun-Cheol et. al.
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities
score: 1.3736413, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Jun-Cheol et. al.
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities
score: 1.3736413, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Jun-Cheol et. al.
Bioactivity landscape modeling: Chemoinformatic characterization of structure–activity relationships of compounds tested across multiple targets
score: 1.3735406, Bioorganic & Medicinal Chemistry, 2012, Waddell, Jacob; Medina-Franco, José L.
Studies on the interactions between some flavonols and cyclodextrins
score: 1.3733506, Bioorganic & Medicinal Chemistry Letters, 2007, Bergonzi, Maria Camilla et. al.
A fluorescent reporter of ATP binding-competent receptor kinases
score: 1.3733306, Bioorganic & Medicinal Chemistry Letters, 2012, Sicard, Renaud et. al.
Design, synthesis and in vitro antitumor activity of new trans 2-[2-(heteroaryl)vinyl]-1,3-dimethylimidazolium iodides
score: 1.3731718, Bioorganic & Medicinal Chemistry, 2004, Ballistreri, Francesco P. et. al.
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.
score: 1.3730238, Antimicrobial agents and chemotherapy, 2008, Zhang, Xiujun et. al.
Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies
score: 1.3729756, Bioorganic & Medicinal Chemistry, 2002, Fossa, Paola et. al.
New triple-helix DNA stabilizing agents
score: 1.3729465, Bioorganic & Medicinal Chemistry Letters, 2005, Strekowski, Lucjan et. al.
Synthesis, characterization and antiproliferative studies of the enantiomers of cis-[(1,2-camphordiamine)dichloro]platinum(II) complexes
score: 1.3729413, Bioorganic & Medicinal Chemistry, 2008, Montaña, Ángel M. et. al.
Synthesis of dimeric acridine derived antivirals
score: 1.3728505, Bioorganic & Medicinal Chemistry Letters, 2004, Csuk, René et. al.
DNA damaging activity of ellagic acid derivatives
score: 1.3728022, Bioorganic & Medicinal Chemistry, 2003, Xu, Ya-ming et. al.
Chemical synthesis and calcium release activity of N 1-ether strand substituted cADPR mimic
score: 1.3727428, Bioorganic & Medicinal Chemistry Letters, 2002, Huang, Li-Jun et. al.
Design and synthesis of glycosidase inhibitor 5-amino-1,2,3,4-cyclohexanetetrol derivatives from (−)- vibo-quercitol
score: 1.3727384, Bioorganic & Medicinal Chemistry, 2005, Ogawa, Seiichiro et. al.
Novel fluorescent risedronates: Synthesis, photodynamic inactivation and imaging ofBacillus subtilis
score: 1.3726459, Bioorganic & Medicinal Chemistry Letters, 2013, Zhou, Li-Sheng et. al.
Novel fluorescent risedronates: Synthesis, photodynamic inactivation and imaging ofBacillus subtilis
score: 1.3726459, Bioorganic & Medicinal Chemistry Letters, 2013, Zhou, Li-Sheng et. al.
Novel fluorescent risedronates: Synthesis, photodynamic inactivation and imaging ofBacillus subtilis
score: 1.3726459, Bioorganic & Medicinal Chemistry Letters, 2013, Zhou, Li-Sheng et. al.
Small molecule activators of proteasome-related HslV peptidase
score: 1.3726109, Bioorganic & Medicinal Chemistry Letters, 2012, Rashid, Yasmeen et. al.
An efficient synthesis and biological activity of substituted p-benzoquinones
score: 1.3724877, Bioorganic & Medicinal Chemistry, 2006, Batra, Manoj; Kriplani, Prashant; Batra, Chhavi; Ojha, K.G.
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells
score: 1.3724367, Bioorganic & Medicinal Chemistry Letters, 2012, Hoang, Minh-Hien et. al.
The 4′,4′-difluoro analog of 5′-noraristeromycin: A new structural prototype for possible antiviral drug development toward orthopoxvirus and cytomegalovirus
score: 1.3724071, Bioorganic & Medicinal Chemistry, 2005, Roy, Atanu et. al.
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
score: 1.3722736, European Journal of Medicinal Chemistry, 2012, Altıntop, Mehlika Dilek et. al.
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
score: 1.3722736, European Journal of Medicinal Chemistry, 2012, Altıntop, Mehlika Dilek et. al.
Synthesis and biological evaluation of technetium-labeled d-glucose-MAG 3 derivative as agent for tumor diagnosis
score: 1.3722529, Bioorganic & Medicinal Chemistry Letters, 2009, de Barros, André Luís Branco et. al.
Zanamivir susceptibility monitoring and characterization of influenza virus clinical isolates obtained during phase II clinical efficacy studies.
score: 1.3720299, Antimicrobial agents and chemotherapy, 2000, Barnett, J M et. al.
Polymer-supported ferrocenyl oxazolines for the catalyzed highly enantioselective phenyl transfer to aldehydes
score: 1.3719621, Bioorganic & Medicinal Chemistry Letters, 2002, Bolm, Carsten; Hermanns, Nina; Claßen, Arno; Muñiz, Kilian
A practical post-modification synthesis of oligodeoxynucleotides containing 4,7-diaminoimidazo[5’,4’:4,5]pyrido[2,3-d]pyrimidine nucleoside
score: 1.3718776, Bioorganic & Medicinal Chemistry, 2012, Tarashima, Noriko et. al.
Visualizing antibody-Catalyzed retro-Aldol-Retro-Michael reactions
score: 1.3716705, Bioorganic & Medicinal Chemistry Letters, 2001, Tanaka, Fujie et. al.
A colorimetric titration method for quantification of millimolar glucose in a pH 7.4 aqueous phosphate buffer
score: 1.371631, Bioorganic & Medicinal Chemistry Letters, 2005, Boduroglu, Serhan et. al.
Induction of efflux-mediated macrolide resistance in Streptococcus pneumoniae.
score: 1.3716183, Antimicrobial agents and chemotherapy, 2011, Chancey, Scott T et. al.
Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency.
score: 1.3714706, Antimicrobial agents and chemotherapy, 2011, Pathak, Sarika; Chauhan, Virander Singh
QSAR study of 4-phenylpiperidine derivatives as μ opioid agonists by neural network method
score: 1.3714361, European Journal of Medicinal Chemistry, 2006, Wang, Xing-hai; Tang, Yun; Xie, Qiong; Qiu, Zhui-bai
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
score: 1.3714261, European Journal of Medicinal Chemistry, 2012, Thapa, Pritam et. al.
Facile and efficient one-pot synthesis of 4β-arylaminopodophyllotoxins: synthesis of DNA topoisomerase II inhibitors (NPF and W-68)
score: 1.3714083, Bioorganic & Medicinal Chemistry Letters, 2000, Kamal, Ahmed; Laxman, N.; Ramesh, G.
Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K ATP channel openers
score: 1.371253, Bioorganic & Medicinal Chemistry, 2004, Drizin, Irene et. al.
Synthesis of a folate functionalized PEGylated poly(propylene imine) dendrimer as prospective targeted drug delivery system
score: 1.3711163, Bioorganic & Medicinal Chemistry Letters, 2010, Sideratou, Zili et. al.
Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of dibenzofluorene derivatives
score: 1.3710976, Bioorganic & Medicinal Chemistry, 2000, Becker, Frederick F et. al.
How do antibodies and lectins recognize histo-blood group antigens? A 3D-QSAR study by comparative molecular field analysis (CoMFA)
score: 1.3710447, Bioorganic & Medicinal Chemistry, 1996, Imberty, Anne et. al.
Synthesis and antibacterial activity of some 5-(4-biphenylyl)-7-aryl[3,4-d] [1,2,3]-benzothiadiazoles
score: 1.3709536, European Journal of Medicinal Chemistry, 2005, Balasankar, T.; Gopalakrishnan, M.; Nagarajan, S.
Scaleable and efficient synthesis of 2′-deoxy-2′- N-phthaloyl nucleoside phosphoramidites for oligonucleotide synthesis
score: 1.3708832, Bioorganic & Medicinal Chemistry Letters, 2002, Karpeisky, Alexander et. al.
Complete sequence of a novel 178-kilobase plasmid carrying bla(NDM-1) in a Providencia stuartii strain isolated in Afghanistan.
score: 1.3705447, Antimicrobial agents and chemotherapy, 2012, McGann, Patrick et. al.
Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation
score: 1.370488, Bioorganic & Medicinal Chemistry Letters, 2005, Chung, Hwa-Jin et. al.
Analogs of Eu 3+ DOTAM-Gly-Phe-OH and Tm 3+ DOTAM-Gly-Lys-OH: Synthesis and magnetic properties of potential PARACEST MRI contrast agents
score: 1.3704473, Bioorganic & Medicinal Chemistry, 2008, Suchý, Mojmír et. al.
Syntheses and biological activity of C-3′-difluoromethyl-taxoids
score: 1.3702709, Bioorganic & Medicinal Chemistry, 2000, Ojima, Iwao et. al.
Synthesis and properties of 2′- O,4′- C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides
score: 1.3701632, Bioorganic & Medicinal Chemistry, 2003, Morita, Koji et. al.
Azide-alkyne cycloaddition en route to novel 1H-1,2,3-triazole tethered isatin conjugates with in vitro cytotoxic evaluation
score: 1.370069, European Journal of Medicinal Chemistry, 2012, Singh, Pardeep et. al.
Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors.
score: 1.3700252, Antimicrobial agents and chemotherapy, 2002, Maguire, Michael et. al.
Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors
score: 1.3697976, Bioorganic & Medicinal Chemistry, 2004, Nakamura, Toshio et. al.
Azithromycin–sulfonamide conjugates as inhibitors of resistant Streptococcus pyogenes strains
score: 1.3697141, European Journal of Medicinal Chemistry, 2007, Bukvić Krajačić, Mirjana et. al.
Synthesis of glycoporphyrin derivatives and their antiviral activity against herpes simplex virus types 1 and 2
score: 1.3696042, Bioorganic & Medicinal Chemistry, 2005, Tomé, João P.C. et. al.
Synthesis and cellular uptake of a fluorescently labeled cyclic PNA-based compound
score: 1.3694794, Bioorganic & Medicinal Chemistry Letters, 2004, Caldarelli, Sergio et. al.
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment
score: 1.369293, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Dong-Hwan et. al.
Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide.
score: 1.3692886, Antimicrobial agents and chemotherapy, 2006, Eckert, Randal et. al.
Modification of the butenyl-spinosyns utilizing cross-metathesis
score: 1.3692667, Bioorganic & Medicinal Chemistry, 2009, Daeuble, John et. al.
Antibiotic coresistance in extended-spectrum-beta-lactamase-producing Enterobacteriaceae and in vitro activity of tigecycline.
score: 1.3692458, Antimicrobial agents and chemotherapy, 2006, Morosini, María-Isabel et. al.
Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline
score: 1.3692302, Bioorganic & Medicinal Chemistry Letters, 2003, Goodyer, Claire L.M. et. al.
Enzyme-catalyzed prodrug approaches for the histamine H 3-receptor agonist ( R)-α-methylhistamine
score: 1.3692295, Bioorganic & Medicinal Chemistry, 2001, Stark, Holger et. al.
Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species
score: 1.368971, European Journal of Medicinal Chemistry, 2012, Vianna, D.R. et. al.
Tumor necrosis factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study
score: 1.368954, Bioorganic & Medicinal Chemistry, 1997, Miyachi, Hiroyuki et. al.
Development of triazene prodrugs for ADEPT strategy: New insights into drug delivery system based on carboxypeptidase G2 activation
score: 1.3689518, Bioorganic & Medicinal Chemistry Letters, 2012, Capucha, Verónica et. al.
Development of triazene prodrugs for ADEPT strategy: New insights into drug delivery system based on carboxypeptidase G2 activation
score: 1.3689518, Bioorganic & Medicinal Chemistry Letters, 2012, Capucha, Verónica et. al.
Development of triazene prodrugs for ADEPT strategy: New insights into drug delivery system based on carboxypeptidase G2 activation
score: 1.3689518, Bioorganic & Medicinal Chemistry Letters, 2012, Capucha, Verónica et. al.
Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity
score: 1.3689248, European Journal of Medicinal Chemistry, 2012, Cui, Yanli et. al.
Design, synthesis and photobiological properties of 3,4-cyclopentenepsoralens
score: 1.368924, Bioorganic & Medicinal Chemistry, 2005, Gia, Ornella et. al.
Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives
score: 1.3688607, European Journal of Medicinal Chemistry, 2012, Giles, D. et. al.
Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives
score: 1.3688607, European Journal of Medicinal Chemistry, 2012, Giles, D. et. al.
Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives
score: 1.3688607, European Journal of Medicinal Chemistry, 2012, Giles, D. et. al.
l-Prolinol as a highly enantioselective catalyst for Michael addition of cyclohexanone to nitroolefins
score: 1.3688477, Bioorganic & Medicinal Chemistry Letters, 2009, Chua, Pei Juan; Tan, Bin; Zeng, Xiaofei; Zhong, Guofu
Structure-Based 3-D-QSAR Analysis of Marine Indole Alkaloids
score: 1.368728, Bioorganic & Medicinal Chemistry, 2002, Jiang, Biao et. al.
Total and local (atom and atom type) molecular quadratic indices: significance interpretation, comparison to other molecular descriptors, and QSPR/QSAR applications
score: 1.3686192, Bioorganic & Medicinal Chemistry, 2004, Marrero Ponce, Yovani
Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
score: 1.3685846, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
score: 1.3685846, European Journal of Medicinal Chemistry, 2012, Puthiyapurayil, Pushpan et. al.
Exploring DNA topoisomerase I inhibition by the benzo[ c]phenanthridines fagaronine and ethoxidine using steered molecular dynamics
score: 1.3685538, Bioorganic & Medicinal Chemistry, 2007, Clark, Rachel L. et. al.
New phenolic inhibitors of yeast homoserine dehydrogenase
score: 1.3685526, Bioorganic & Medicinal Chemistry, 2004, Ejim, Linda et. al.
Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations
score: 1.368444, Bioorganic & Medicinal Chemistry, 2012, Wittine, Karlo et. al.
Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations
score: 1.368444, Bioorganic & Medicinal Chemistry, 2012, Wittine, Karlo et. al.
Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457
score: 1.3683826, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Fa-Zuo et. al.
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors
score: 1.3683342, Bioorganic & Medicinal Chemistry, 2012, Marriott, Karla-Sue C. et. al.
In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi.
score: 1.3683273, Antimicrobial agents and chemotherapy, 2008, da Silva, Cristiane França et. al.
Docking dinucleotides to HIV-1 integrase carboxyl-terminal domain to find possible DNA binding sites
score: 1.3682952, Bioorganic & Medicinal Chemistry Letters, 2005, Zhu, Hai Mei; Chen, Wei Zu; Wang, Cun Xin
LIV-3D-QSAR models for PGI 2 receptor ligands using multiple conformations
score: 1.3679616, European Journal of Medicinal Chemistry, 2004, Azevedo Martins, Rita Cristina et. al.
Synthesis of betaglycan-type tetraosyl hexapeptide: a possible precursor regulating enzymatic elongation toward heparin
score: 1.3679271, Bioorganic & Medicinal Chemistry Letters, 2002, Tamura, Jun-ichi; Yamaguchi, Akihiro; Tanaka, Junko
Investigating highly crosslinked macroporous resins for solid-phase synthesis
score: 1.3679179, Bioorganic & Medicinal Chemistry Letters, 1998, Hori, Manabu et. al.
Novel mutations in a patient isolate of Streptococcus agalactiae with reduced penicillin susceptibility emerging after long-term oral suppressive therapy.
score: 1.3678887, Antimicrobial agents and chemotherapy, 2011, Longtin, Jean et. al.
Solid-phase synthesis of a pepticinnamin E Library
score: 1.3678864, Bioorganic & Medicinal Chemistry, 2003, Thutewohl, Michael; Waldmann, Herbert
A practical post-modification synthesis of oligodeoxynucleotides containing 4,7-diaminoimidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidine nucleoside
score: 1.3678339, Bioorganic & Medicinal Chemistry, 2012, Tarashima, Noriko et. al.
A practical post-modification synthesis of oligodeoxynucleotides containing 4,7-diaminoimidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidine nucleoside
score: 1.3678339, Bioorganic & Medicinal Chemistry, 2012, Tarashima, Noriko et. al.
A practical post-modification synthesis of oligodeoxynucleotides containing 4,7-diaminoimidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidine nucleoside
score: 1.3678339, Bioorganic & Medicinal Chemistry, 2012, Tarashima, Noriko et. al.
On the preparative use of recombinant β(1–3)galactosyl-transferase
score: 1.3678098, Bioorganic & Medicinal Chemistry Letters, 1998, Baisch, Gabi et. al.
d- myo-Inositol-1,4,5-trisphosphate and Adenophostin Mimics: Importance of the Spatial Orientation of a Phosphate Group on the Biological Activity
score: 1.3677739, Bioorganic & Medicinal Chemistry, 2002, Roussel, Fabien et. al.
Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells
score: 1.3677587, Bioorganic & Medicinal Chemistry Letters, 2012, Ikeda, Mamiko et. al.
Shape selective recognition of T·A base pairs by hairpin polyamides containing N-Terminal 3-Methoxy (and 3-Chloro) thiophene residues
score: 1.367682, Bioorganic & Medicinal Chemistry, 2003, Foister, Shane et. al.
Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation
score: 1.3675711, Bioorganic & Medicinal Chemistry, 2005, Shen, Yuehai et. al.
Effects of bromide upon reaction of nucleosides with hydrogen peroxide induced by ultraviolet light
score: 1.3675655, Bioorganic & Medicinal Chemistry Letters, 2009, Suzuki, Toshinori et. al.
Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH 2) 3CO-His- d-Phe-Arg-Trp-NH 2]. An additional binding site within the human melanocortin receptor 1?
score: 1.3674942, Bioorganic & Medicinal Chemistry Letters, 2004, Koikov, L.N et. al.
Selective G-quadruplex ligands: The significant role of side chain charge density in a series of perylene derivatives
score: 1.3674813, Bioorganic & Medicinal Chemistry Letters, 2009, Micheli, Emanuela et. al.
Solid-phase synthesis of muramyl dipeptide (mdp) derivatives using a multipin method
score: 1.3674733, Bioorganic & Medicinal Chemistry Letters, 2000, Liu, Gang; Zhang, Shuo-De; Xia, Shu-Quan; Ding, Zhen-Kai
Synthesis and biological evaluation of novel anticancer bivalent colchicine–tubulizine hybrids
score: 1.3674431, Bioorganic & Medicinal Chemistry, 2012, Malysheva, Yulia B. et. al.
Synthesis and biological evaluation of novel anticancer bivalent colchicine–tubulizine hybrids
score: 1.3674431, Bioorganic & Medicinal Chemistry, 2012, Malysheva, Yulia B. et. al.
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition
score: 1.367307, Bioorganic & Medicinal Chemistry Letters, 2013, Nishimori, Isao et. al.
An investigation of the N-demethylation of 3-deoxymorphine and the affinity of the alkylation products to μ, δ, and κ receptors
score: 1.3672564, Bioorganic & Medicinal Chemistry, 2004, Csutoras, Csaba et. al.
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring
score: 1.3672509, European Journal of Medicinal Chemistry, 2012, Mohammed Iqbal, A.K. et. al.
Novel c-4 heteroaromatic kainoid analogues: a parallel synthesis approach
score: 1.3672451, Bioorganic & Medicinal Chemistry Letters, 2000, Baldwin, Jack E.; Fryer, Andrew M.; Pritchard, Gareth J.
Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase
score: 1.3671906, Bioorganic & Medicinal Chemistry, 1998, Holstein, Sarah A et. al.
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.
score: 1.3670804, Antimicrobial agents and chemotherapy, 2006, Gros, Ludovic et. al.
Genetic basis for differential activities of fluconazole and voriconazole against Candida krusei.
score: 1.3669082, Antimicrobial agents and chemotherapy, 2003, Fukuoka, Takashi et. al.
Synthesis of C3-arylated -3-deazauridine derivatives with potent anti-HSV-1 activities
score: 1.3668739, Bioorganic & Medicinal Chemistry Letters, 2012, Lalut, Julien et. al.
Biotin sulfone tagged oligomannosides as immunogens for eliciting antibodies against specific mannan epitopes
score: 1.366867, Bioorganic & Medicinal Chemistry, 2012, Despras, Guillaume et. al.
A straightforward synthetic approach for roxindole
score: 1.3668212, Bioorganic & Medicinal Chemistry Letters, 1999, Lange, Jos H.M et. al.
Specific binding capacity of β-cyclodextrin with cis and trans enalapril: Physicochemical characterization and structural studies by molecular modeling
score: 1.366761, Bioorganic & Medicinal Chemistry, 2008, Zoppi, Ariana; Quevedo, Mario A.; Longhi, Marcela R.
Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5- O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands
score: 1.3667116, European Journal of Medicinal Chemistry, 2004, Lee, Jeewoo et. al.
A New α,β,γ,δ-Unsaturated carboxylic acid and three new cyclic peroxides from the marine sponge, Monotria japonica, which selectively lyse starfish oocytes without affecting nuclear morphology
score: 1.3667109, Bioorganic & Medicinal Chemistry, 2003, Yanai, Mihoko et. al.
3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3- f]indole-5,10-dione for circumvention of anticancer drug resistance
score: 1.3666053, Bioorganic & Medicinal Chemistry, 2005, Shchekotikhin, Andrey E. et. al.
The cruciferous phytoalexins brassinin and cyclobrassinin are intermediates in the biosynthesis of brassilexin
score: 1.3663229, Bioorganic & Medicinal Chemistry Letters, 1998, Soledade, M.; Pedras, C.; Loukaci, Ali; Okanga, Francis I.
Velnacrine thiaanalogues as potential agents for treating alzheimer's disease
score: 1.3662922, Bioorganic & Medicinal Chemistry, 2001, Tabarrini, Oriana et. al.
Design, synthesis, and evaluation of a novel series of α-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) α/δ dual agonists for the treatment of metabolic syndrome
score: 1.3661957, Bioorganic & Medicinal Chemistry, 2006, Kasuga, Jun-ichi et. al.
Novel route to chaetomellic acid A and analogues: Serendipitous discovery of a more competent FTase inhibitor
score: 1.3661755, Bioorganic & Medicinal Chemistry, 2013, Bellesia, Franco et. al.
Efficient double-strand scission of plasmid DNA by quaternized-chitosan zinc complex
score: 1.3658354, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Qi et. al.
Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase–dihydropteroate synthase
score: 1.3658062, Bioorganic & Medicinal Chemistry, 2006, de Beer, Tjaart A.P.; Louw, Abraham I.; Joubert, Fourie
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3
score: 1.3657199, Chemmedchem, 2011, Cleghorn, Laura A T et. al.
Simultaneous tritium labelling of two potent 5-HT 4 ligands
score: 1.3655102, European Journal of Medicinal Chemistry, 2010, Sobrio, Franck et. al.
Modifications of the α,β-Double bond in chalcones only Marginally affect the antiprotozoal activities
score: 1.3654236, Bioorganic & Medicinal Chemistry, 1998, Nielsen, Simon Feldbæk et. al.
Synthesis of protected guanidinium linked dinucleoside incorporable into an oligonucleotide using solid phase DNA methodology
score: 1.3654183, Bioorganic & Medicinal Chemistry Letters, 1998, Barawkar, Dinesh A.; Linkletter, Barry; Bruice, Thomas C.
Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem derivatives
score: 1.365411, European Journal of Medicinal Chemistry, 2002, Oh, Chang-Hyun; Cho, Han-Won; Baek, Daejin; Cho, Jung-Hyuck
Synthesis and fungicidal activity of enantiomerically pure ( R)- and ( S)-silicon-containing azole fungicides
score: 1.3653796, Bioorganic & Medicinal Chemistry, 2004, Itoh, Hiroyuki et. al.
Determination of the enantiomeric purity of the phytoalexins spirobrassinins by 1H NMR using chiral solvation
score: 1.3651636, Bioorganic & Medicinal Chemistry Letters, 2004, Pedras, M.S.C.; Hossain, M.; Sarwar, M.G.; Montaut, S.
Diamine preparation for synthesis of a water soluble Ni(II) salen complex
score: 1.3651198, Bioorganic & Medicinal Chemistry Letters, 1999, Shearer, Jason M.; Rokita, Steven E.
Properties of mutant SHV-5 beta-lactamases constructed by substitution of isoleucine or valine for methionine at position 69.
score: 1.3650953, Antimicrobial agents and chemotherapy, 1998, Giakkoupi, P et. al.
N,N-Dimethylsphingosine conjugates of poly- l-glutamic acid: Synthesis, characterization, and initial biological evaluation
score: 1.36493, Bioorganic & Medicinal Chemistry Letters, 2009, Ghosh, Sukhen C. et. al.
Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase
score: 1.3648548, Bioorganic & Medicinal Chemistry Letters, 2002, Alcaro, Stefano et. al.
Self-calibrating viscosity probes: Design and subcellular localization
score: 1.3648123, Bioorganic & Medicinal Chemistry, 2012, Dakanali, Marianna et. al.
Self-calibrating viscosity probes: Design and subcellular localization
score: 1.3648123, Bioorganic & Medicinal Chemistry, 2012, Dakanali, Marianna et. al.
Self-calibrating viscosity probes: Design and subcellular localization
score: 1.3648123, Bioorganic & Medicinal Chemistry, 2012, Dakanali, Marianna et. al.
A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells
score: 1.3647733, Bioorganic & Medicinal Chemistry, 2012, Ikeuchi, Hideyuki et. al.
Chemo-enzymatic synthesis of glycosylated insulin using a GlcNAc tag
score: 1.3647705, Bioorganic & Medicinal Chemistry, 2010, Tomabechi, Yusuke et. al.
Pharmacological properties of a new antimalarial bisthiazolium salt, T3, and a corresponding prodrug, TE3.
score: 1.3646658, Antimicrobial agents and chemotherapy, 2005, Nicolas, Olivier et. al.
Influence of methoxy groups on the antiproliferative effects of [Fe III(salophene-OMe)Cl] complexes
score: 1.3646445, European Journal of Medicinal Chemistry, 2010, Hille, Annegret; Gust, Ronald
Multisubstrate analogue based on 5,8,10-trideazafolate
score: 1.3645762, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L. et. al.
Synthesis and cytotoxic activity of N-(2-Diethylamino)ethylcarboxamide and other derivatives of 10 H-Quindoline
score: 1.3645432, Bioorganic & Medicinal Chemistry, 2002, Chen, Junjie et. al.
Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance.
score: 1.3643543, Antimicrobial agents and chemotherapy, 2005, Fritsche, Thomas R et. al.
Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis.
score: 1.3643269, Antimicrobial agents and chemotherapy, 2006, Gruppo, Veronica et. al.
Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening
score: 1.3642668, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Xing Wen; Mai, Jun Hua; Xu, Yu Hong
Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals
score: 1.3640537, Bioorganic & Medicinal Chemistry Letters, 2008, Masuda, Yuichi et. al.
6-Carboxy-5,7-diarylcyclopenteno[1,2- b]pyridine derivatives
score: 1.3639968, Bioorganic & Medicinal Chemistry, 2002, Niiyama, Kenji et. al.
Photochemical DNA cleavage by novel water-soluble sulfonated dihydroxy phosphorus(V) tetrabenzotriazacorrole
score: 1.3638614, Bioorganic & Medicinal Chemistry Letters, 2008, Huang, Lei; Zhong, Cheng; Zhang, Fushi; Tung, Chen-Ho
Eponemycin analogues: syntheses and use as probes of angiogenesis
score: 1.3637992, Bioorganic & Medicinal Chemistry, 1998, Sin, Ny; Meng, Lihao; Auth, Hak; Crews, Craig M.
Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one
score: 1.3636758, Bioorganic & Medicinal Chemistry, 2012, Więckowski, Krzysztof et. al.
Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one
score: 1.3636758, Bioorganic & Medicinal Chemistry, 2012, Więckowski, Krzysztof et. al.
Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ring
score: 1.363651, European Journal of Medicinal Chemistry, 2003, Castro, M.Angeles et. al.
Glycosyl-transferase catalyzed assemblage of sialyl-lewis x-saccharopeptides
score: 1.3636121, Bioorganic & Medicinal Chemistry, 1998, Baisch, Gabi; Öhrlein, Reinhold
Effect of Modification of 6-[(Aminoalkyl)amino]-7 H-benzo[ e]-perimidin-7-ones on Their Cytotoxic Activity Toward Sensitive and Multidrug Resistant Tumor Cell Lines. Synthesis and Biological Evaluation
score: 1.3635472, Bioorganic & Medicinal Chemistry, 2002, Dzieduszycka, Maria et. al.
Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective α 1D-adrenergic receptor ligand
score: 1.363528, Bioorganic & Medicinal Chemistry, 2004, McGinty, Susan J. et. al.
Synthesis and 31P NMR characterization of new low toxic highly sensitive pH probes designed for in vivo acidic pH studies
score: 1.363473, Bioorganic & Medicinal Chemistry, 2002, Martel, Sophie et. al.
Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity
score: 1.3634432, Bioorganic & Medicinal Chemistry Letters, 2012, Guo, Zhi Kai et. al.
Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay
score: 1.3634275, Bioorganic & Medicinal Chemistry, 2004, Zhang, Han-Zhong et. al.
Synthesis, antitumor activity and SAR study of novel [1,2,4]triazino[4,5-a]benzimidazole derivatives
score: 1.3633681, European Journal of Medicinal Chemistry, 2012, El-Nassan, Hala Bakr
Synthesis, antitumor activity and SAR study of novel [1,2,4]triazino[4,5-a]benzimidazole derivatives
score: 1.3633681, European Journal of Medicinal Chemistry, 2012, El-Nassan, Hala Bakr
Synthesis of (3 R)-carboxy pyrrolidine (a β-proline analogue) and its oligomer
score: 1.3632229, Bioorganic & Medicinal Chemistry Letters, 2000, Kim, Yong Jip et. al.
Relationship between structure and P-glycoprotein inhibitory activity of dimeric peptides related to the Dmt-Tic pharmacophore
score: 1.3631735, Bioorganic & Medicinal Chemistry Letters, 2012, Ambo, Akihiro et. al.
Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo
score: 1.3631194, Bioorganic & Medicinal Chemistry, 2005, Chand, Pooran et. al.
Synthesis, structure, toxicological and pharmacological investigations of 4-hydroxycoumarin derivatives
score: 1.3630668, European Journal of Medicinal Chemistry, 2006, Manolov, Ilia; Maichle-Moessmer, Caecilia; Danchev, Nicolay
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii
score: 1.3628115, Bioorganic & Medicinal Chemistry Letters, 2012, Quang, Tran Hong et. al.
Synthesis of 4-aryl-3,4-dihydropyrimidin-2(1 H)-thione derivatives as potential calcium channel blockers
score: 1.3628017, Bioorganic & Medicinal Chemistry, 2006, Zorkun, İnci Selin et. al.
Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.
score: 1.3626942, Antimicrobial agents and chemotherapy, 2011, Mitchell, Gabriel et. al.
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
score: 1.3625124, Bioorganic & Medicinal Chemistry Letters, 2010, de Sá, Arsénio et. al.
Identification and evaluation of twin-arginine translocase inhibitors.
score: 1.36244, Antimicrobial agents and chemotherapy, 2012, Vasil, Michael L; Tomaras, Andrew P; Pritchard, Arthur E
Toward an HDAC6 inhibitor: synthesis and conformational analysis of cyclic hexapeptide hydroxamic acid designed from α-tubulin sequence
score: 1.3623506, Bioorganic & Medicinal Chemistry, 2004, Jose, Binoy et. al.
Site-specific PEGylation of proteins containing unnatural amino acids
score: 1.3623433, Bioorganic & Medicinal Chemistry Letters, 2004, Deiters, Alexander et. al.
The alkaloids and other constituents from the root and stem of Aristolochia elegans
score: 1.3623395, Bioorganic & Medicinal Chemistry, 2004, Shi, Li-Shian et. al.
Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides
score: 1.36226, Bioorganic & Medicinal Chemistry, 2001, Matsuda, Hisashi et. al.
99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques
score: 1.3622443, Bioorganic & Medicinal Chemistry Letters, 2010, Ono, Masahiro et. al.
Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans
score: 1.362207, Bioorganic & Medicinal Chemistry, 2004, Sagar, Kadali S et. al.
Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes.
score: 1.3619576, Antimicrobial agents and chemotherapy, 2005, von Eiff, Christof et. al.
Ceftobiprole Efficacy In Vitro against Panton-Valentine Leukocidin Production and In Vivo against Community-Associated Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rabbits.
score: 1.3618896, Antimicrobial agents and chemotherapy, 2012, Saleh-Mghir, Azzam et. al.
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
score: 1.3618791, European Journal of Medicinal Chemistry, 2012, Barbosa, Luiz Carlos Bertucci et. al.
Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives
score: 1.3618393, European Journal of Medicinal Chemistry, 2012, He, Xianran et. al.
Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase
score: 1.3618358, Bioorganic & Medicinal Chemistry Letters, 2013, Powell, Noel A. et. al.
Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone.
score: 1.361758, Antimicrobial agents and chemotherapy, 2004, Shih, Shin-Ru et. al.
Synthesis of nucleoside phosphosulfates
score: 1.3614647, Bioorganic & Medicinal Chemistry Letters, 2012, Kowalska, Joanna et. al.
Synthesis of nucleoside phosphosulfates
score: 1.3614647, Bioorganic & Medicinal Chemistry Letters, 2012, Kowalska, Joanna et. al.
Synthesis of nucleoside phosphosulfates
score: 1.3614647, Bioorganic & Medicinal Chemistry Letters, 2012, Kowalska, Joanna et. al.
A mercapto analogue of 5′-noraristeromycin
score: 1.3614573, Bioorganic & Medicinal Chemistry, 2002, Das, Subha R et. al.
S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase
score: 1.3612683, Bioorganic & Medicinal Chemistry, 2010, Casida, John E. et. al.
Synthesis of dopamine transporter selective 3-diarylmethoxymethyl-8-arylalkyl-8-azabicyclo[3.2.1]octane derivatives
score: 1.361045, Bioorganic & Medicinal Chemistry, 2006, Zhang, Suhong et. al.
Development of a new enzyme-responsive self-immolative spacer conjugate applicable to the controlled drug release
score: 1.3610147, Bioorganic & Medicinal Chemistry, 2012, Jin, Hui-juan; Lu, Jing; Wu, Xue
Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus.
score: 1.3609344, Antimicrobial agents and chemotherapy, 2003, Kaatz, Glenn W et. al.
GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
score: 1.3608773, Bioorganic & Medicinal Chemistry Letters, 2012, Reith, Alastair D. et. al.
Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones
score: 1.3605324, Bioorganic & Medicinal Chemistry, 2012, Brackman, Gilles et. al.
Estrogenic Activity of B-Fluorinated o-Carborane-1,2-Bisphenol Synthesized via SNAr Reaction
score: 1.3604789, Bioorganic & Medicinal Chemistry Letters, 2012, Ohta, Kiminori; Ogawa, Takumi; Endo, Yasuyuki
Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates
score: 1.3604716, Bioorganic & Medicinal Chemistry Letters, 2007, Koseki, Koichi et. al.
Top-down mass spectrometry on low-resolution instruments: Characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways
score: 1.3603917, Bioorganic & Medicinal Chemistry Letters, 2008, Meluzzi, Dario et. al.
Transformations of bioactive peptides in the presence of sugars—Characterization and stability studies of the adducts generated via the Maillard reaction
score: 1.3603024, Bioorganic & Medicinal Chemistry, 2006, Roščić, Maja; Horvat, Štefica
One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents
score: 1.3602274, European Journal of Medicinal Chemistry, 2005, Khan, Imthyaz A.; Kulkarni, Manohar V.; Sun, Chung-Ming
Integracides: tetracyclic triterpenoid inhibitors of HIV-1 integrase produced by Fusarium sp.
score: 1.3601563, Bioorganic & Medicinal Chemistry, 2003, Singh, Sheo B et. al.
Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction
score: 1.3600828, Bioorganic & Medicinal Chemistry Letters, 1998, Neel, David A.; Jirousek, Michael R.; McDonald, John H.
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II
score: 1.3600787, Bioorganic & Medicinal Chemistry Letters, 2006, Menchise, Valeria et. al.
Synthesis and characterization of new and potent α-lipoic acid derivatives
score: 1.3599464, Bioorganic & Medicinal Chemistry, 2004, Gruzman, Arie et. al.
Novel Tween® 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma
score: 1.3598509, Bioorganic & Medicinal Chemistry Letters, 2010, Masotti, Andrea et. al.
Stereospecificity of hydrogen transfer by the NAD +-linked alcohol dehydrogenase from the Antarctic psychrophile Moraxella sp. TAE123
score: 1.3597772, Bioorganic & Medicinal Chemistry Letters, 1999, Velonia, Kelly et. al.
Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands
score: 1.359715, Bioorganic & Medicinal Chemistry Letters, 2000, Mohler, Debra L; Shen, Gang; Dotse, Anthony K
A comparative study on the inhibition of human and bacterial kynureninase by novel bicyclic kynurenine analogues
score: 1.3595734, Bioorganic & Medicinal Chemistry, 2001, Fitzgerald, Deirdre H. et. al.
Identification of small molecule inhibitors against SecA of Candidatus Liberibacter asiaticus by structure based design
score: 1.3595497, European Journal of Medicinal Chemistry, 2012, Akula, Nagaraju; Trivedi, Pankaj; Han, Frank Q.; Wang, Nian
A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity
score: 1.3595407, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Dao-Ping et. al.
A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity
score: 1.3595407, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Dao-Ping et. al.
A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity
score: 1.3595407, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Dao-Ping et. al.
Synthesis, cytotoxic and antioxidant evaluations of amino derivatives from perezone
score: 1.3594749, Bioorganic & Medicinal Chemistry, 2012, Concepción Lozada, M. et. al.
Ophiobolin M and analogues, noncompetitive inhibitors of ivermectin binding with nematocidal activity
score: 1.3592443, Bioorganic & Medicinal Chemistry, 1996, Tsipouras, Athanasios et. al.
Synthesis of phenanthridinium–bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumour activity of mono- and bis-nucleobase conjugates
score: 1.3592442, European Journal of Medicinal Chemistry, 2006, Tumir, L.-M. et. al.
Synthesis and binding affinities of methylvesamicol analogs for the acetylcholine transporter and sigma receptor
score: 1.359217, Bioorganic & Medicinal Chemistry, 2006, Shiba, Kazuhiro et. al.
Solid-Phase synthesis of diamine and polyamine amino acid derivatives as HIV-1 tat-TAR binding inhibitors
score: 1.3591428, Bioorganic & Medicinal Chemistry, 2003, Jimenez Bueno, G; Klimkait, T; Gilbert, I.H; Simons, C
Facile synthesis of peptide–porphyrin conjugates: Towards artificial catalase
score: 1.3587266, Bioorganic & Medicinal Chemistry, 2010, Umezawa, Naoki et. al.
Dynamic kinetic asymmetric transfer hydrogenation of racemic 2,4-diaryl-2,3-dihydrobenzo[ b][1,4]diazepines catalyzed by chiral phosphoric acids
score: 1.3585989, Bioorganic & Medicinal Chemistry Letters, 2009, Han, Zhi-Yong; Xiao, Han; Gong, Liu-Zhu
Downsizing of an HIV–cell fusion inhibitor, T22 ([Tyr 5, 12, Lys 7]-Polyphemusin II), with the maintenance of anti-HIV activity and solution structure 1
score: 1.3585129, Bioorganic & Medicinal Chemistry, 1998, Tamamura, Hirokazu et. al.
A proposed molecular basis for the selective resveratrol inhibition of the PGHS-1 peroxidase activity
score: 1.3584776, Bioorganic & Medicinal Chemistry, 2005, Kümmerle, Arthur E. et. al.
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents
score: 1.3584726, Bioorganic & Medicinal Chemistry Letters, 2012, Kumbhare, Ravindra M. et. al.
Simplified bicyclic pyridinol analogues protect mitochondrial function
score: 1.3584276, Bioorganic & Medicinal Chemistry, 2012, Cai, Xiaoqing et. al.
Simplified bicyclic pyridinol analogues protect mitochondrial function
score: 1.3584276, Bioorganic & Medicinal Chemistry, 2012, Cai, Xiaoqing et. al.
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
score: 1.3584166, Antimicrobial agents and chemotherapy, 2005, Hernandez-Santiago, Brenda I et. al.
Synthesis of a water-soluble analog of 6-methyl-3-N-alkyl catechol labeled with carbon 13: NMR approach to the reactivity of poison ivy/oak sensitizers toward proteins
score: 1.3583512, Bioorganic & Medicinal Chemistry Letters, 1999, Goetz, Gilles; Meschkat, Emmanuel; Lepoittevin, Jean-Pierre
A molecular model for cocaine binding by the immunotherapeutic human/mouse chimeric monoclonal antibody 2E2
score: 1.3582883, European Journal of Medicinal Chemistry, 2010, Lape, Michael; Paula, Stefan; Ball, William J.
Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives
score: 1.3581837, Bioorganic & Medicinal Chemistry, 2012, Zhang, Li-Rong et. al.
Solid state photochemistry of 1,4-dihydropyridines
score: 1.3581818, Bioorganic & Medicinal Chemistry Letters, 2005, Memarian, Hamid R.; Mirjafari, Arsalan
Conformational analyses of thiirane-based gelatinase inhibitors
score: 1.3581631, Bioorganic & Medicinal Chemistry Letters, 2008, Lee, Mijoon et. al.
1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT 1A, 5-HT 2A, 5-HT 7), α 1-adrenergic, and dopaminergic D 2 receptors, and in vivo 5-HT 1A functional characteristics
score: 1.3581396, Bioorganic & Medicinal Chemistry, 2005, Bojarski, Andrzej J. et. al.
Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds
score: 1.3580864, Bioorganic & Medicinal Chemistry, 1999, Biot, C. et. al.
Cytotoxic isoprenylated xanthones from Cudrania tricuspidata
score: 1.3580093, Bioorganic & Medicinal Chemistry, 2004, Zou, Ying-Shu et. al.
2-Acetylpyridine- and 2-benzoylpyridine-derived hydrazones and their gallium(III) complexes are highly cytotoxic to glioma cells
score: 1.3579952, European Journal of Medicinal Chemistry, 2012, Despaigne, Angel A.R. et. al.
Synthesis and antiviral activity of prodrugs of the nucleoside 1-[2′,3′-Dideoxy-3′-C-(hydroxymethyl)-β- d-erythropentofuranosyl] cytosine
score: 1.3579127, Bioorganic & Medicinal Chemistry, 1998, Mauldin, Scott C. et. al.
Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification
score: 1.3578679, Bioorganic & Medicinal Chemistry Letters, 2010, Bruyère, Hélène; Westwell, Andrew D.; Jones, Arwyn T.
p–Aminobenzoic acid derivatives as acetylcholinesterase inhibitors
score: 1.357867, European Journal of Medicinal Chemistry, 2005, Correa-Basurto, José et. al.
Potent in vitro antimalarial activity of metacycloprodigiosin isolated from Streptomyces spectabilis BCC 4785.
score: 1.3577453, Antimicrobial agents and chemotherapy, 2002, Isaka, Masahiko et. al.
Highly efficient selective oxidation of alcohols to carbonyl compounds catalyzed by ruthenium (III) meso-tetraphenylporphyrin chloride in the presence of molecular oxygen
score: 1.3577249, Bioorganic & Medicinal Chemistry Letters, 2007, Ji, Hong-Bing et. al.
Descriptor-free molecular discovery in large libraries by adaptive substituent reordering
score: 1.3576529, Bioorganic & Medicinal Chemistry Letters, 2008, McAllister, Scott R. et. al.
The C 19 position of 25-Hydroxyvitamin D 3 faces outward in the vitamin D sterol-Binding pocket of vitamin D-Binding protein
score: 1.3575125, Bioorganic & Medicinal Chemistry Letters, 2002, Addo, James K; Swamy, Narasimha; Ray, Rahul
Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models.
score: 1.3574074, Antimicrobial agents and chemotherapy, 1999, Benoit-Vical, F; Robert, A; Meunier, B
Synthesis and binding studies of epibatidine analogues as ligands for the nicotinic acetylcholine receptors
score: 1.3574049, European Journal of Medicinal Chemistry, 2006, Mu, Linjing et. al.
Chalcones and flavonoids as anti-Tuberculosis agents
score: 1.357384, Bioorganic & Medicinal Chemistry, 2002, Lin, Yuh-Meei et. al.
Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids – Highly potent antibacterial agents
score: 1.3573424, European Journal of Medicinal Chemistry, 2012, Sangaraiah, Nagarajan et. al.
Synthesis by microwave irradiation of a substituted benzoxazine parallel library with preferential relaxant activity for guinea pig trachealis
score: 1.3573206, European Journal of Medicinal Chemistry, 2004, Caliendo, Giuseppe et. al.
Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci.
score: 1.3572662, Antimicrobial agents and chemotherapy, 2006, Jones, Ronald N et. al.
Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells
score: 1.3571988, European Journal of Medicinal Chemistry, 2012, Yuan, Jian et. al.
Synthesis and cytotoxic activity of some 17-picolyl and 17-picolinylidene androstane derivatives
score: 1.3570582, European Journal of Medicinal Chemistry, 2012, Djurendić, Evgenija A. et. al.
Synthesis of chlorinated fluoresceins for labeling proteins
score: 1.356931, Bioorganic & Medicinal Chemistry Letters, 2008, Tian, Min et. al.
An Analysis of the Binding of Cocaine Analogues to the Monoamine Transporters Using Tensor Decomposition 3-D QSAR
score: 1.3569177, Bioorganic & Medicinal Chemistry, 2002, Appell, Michael et. al.
A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity
score: 1.3567082, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Dao-Ping et. al.
Synthesis and evaluation of novel multimeric neurotensin(8–13) analogs
score: 1.3566213, Bioorganic & Medicinal Chemistry, 2006, Hultsch, Christina et. al.
Brasilicardins B–D, new tricyclic terpernoids from actinomycete Nocardia brasiliensis
score: 1.3565714, Bioorganic & Medicinal Chemistry, 2004, Komatsu, Kazusei et. al.
The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages
score: 1.356534, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Jin-Hui; Lan, Xiang-Peng; Liu, Yonghong; Jia, Ai-Qun
Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens.
score: 1.3564429, Antimicrobial agents and chemotherapy, 2000, Stevens, D A
3-D QSAR studies of triazolinone based balanced AT 1/AT 2 receptor antagonists
score: 1.3563875, Bioorganic & Medicinal Chemistry, 2001, Pandya, Trupti et. al.
Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor
score: 1.3563759, Bioorganic & Medicinal Chemistry, 2003, Li, Jie Jack et. al.
Modified Tetrahalogenated Benzimidazoles with CK2 Inhibitory Activity Are Active Against Human Prostate Cancer Cells LNCaP in vitro
score: 1.3562695, Bioorganic & Medicinal Chemistry, 2012, Schneider, Carolin C. et. al.
Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing
score: 1.3562521, Bioorganic & Medicinal Chemistry Letters, 2007, Yu, Pengzhan et. al.
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies
score: 1.3560324, European Journal of Medicinal Chemistry, 2012, Colotta, Vittoria et. al.
A comparative binding study of modified Bovine Immunodeficiency Virus TAR RNA against its TAT peptide
score: 1.3560216, Bioorganic & Medicinal Chemistry Letters, 2004, Tok, Jeffrey B.-H.; Bi, Lanrong; Huang, Shuying
Robust fuzzy mappings for QSAR studies
score: 1.3558797, European Journal of Medicinal Chemistry, 2007, Kumar, Mohit; Thurow, Kerstin; Stoll, Norbert; Stoll, Regina
Total synthesis of grassystatin A, a probe for cathepsin E function
score: 1.3558081, Bioorganic & Medicinal Chemistry, 2012, Yang, Siming et. al.
Total synthesis of grassystatin A, a probe for cathepsin E function
score: 1.3558081, Bioorganic & Medicinal Chemistry, 2012, Yang, Siming et. al.
Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes.
score: 1.3557949, Antimicrobial agents and chemotherapy, 2006, Yan, Kang et. al.
Gene therapeutic approach for inhibiting hepatitis C virus replication using a recombinant protein that controls interferon expression.
score: 1.3557706, Antimicrobial agents and chemotherapy, 2010, Joo, Chul Hyun et. al.
Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro.
score: 1.3555647, Antimicrobial agents and chemotherapy, 2004, Delaney, William E et. al.
The synthesis and antimicrobial activity of some new methyl N-arylthiocarbamates, dimethyl N-aryldithiocarbonimidates and 2-arylamino-2-imidazolines
score: 1.3553856, European Journal of Medicinal Chemistry, 2005, Servi, Süleyman; Genc, Murat; Gür, Seher; Koca, Murat
Correlations between the benzene character of acenes or helicenes and simple molecular descriptors
score: 1.3552645, Bioorganic & Medicinal Chemistry Letters, 2004, Khadikar, Padmakar V. et. al.
Prospective acetylcholinesterase inhibitory activity of indole and its analogs
score: 1.3551438, Bioorganic & Medicinal Chemistry Letters, 2012, Khorana, Nantaka et. al.
Designing dendrimers for ocular drug delivery
score: 1.3551153, European Journal of Medicinal Chemistry, 2010, Spataro, Grégory et. al.
The role of molecular size in ligand efficiency
score: 1.3546015, Bioorganic & Medicinal Chemistry Letters, 2007, Reynolds, Charles H.; Bembenek, Scott D.; Tounge, Brett A.
In-silico drug screening method based on the protein–compound affinity matrix using the factor selection technique
score: 1.354572, European Journal of Medicinal Chemistry, 2007, Murali, Sukumaran et. al.
Substituted benzo[ i]phenanthridines as mammalian topoisomerase-Targeting agents
score: 1.3545687, Bioorganic & Medicinal Chemistry, 2003, Makhey, Darshan et. al.
Synthesis and dopamine receptor binding of sulfur-containing aporphines
score: 1.3545088, Bioorganic & Medicinal Chemistry, 2006, Tóth, Miklós et. al.
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors
score: 1.3542849, Bioorganic & Medicinal Chemistry, 2012, Ikuma, Yohei et. al.
Development of hypoxia-sensitive Gd3+-based MRI contrast agents
score: 1.3542509, Bioorganic & Medicinal Chemistry Letters, 2012, Iwaki, Shimpei et. al.
Synthesis of constrained α-amino acid derivatives via ring-closing olefin metathesis
score: 1.3541315, Bioorganic & Medicinal Chemistry Letters, 1998, Kotha, Sambasivarao; Sreenivasachary, Nampally
Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic.
score: 1.3539627, Antimicrobial agents and chemotherapy, 2012, Grossman, Trudy H et. al.
Correlation of blood–brain penetration using structural descriptors
score: 1.3539605, Bioorganic & Medicinal Chemistry, 2006, Katritzky, Alan R. et. al.
Regioselective synthesis and estrogenicity of (±)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins
score: 1.3537605, European Journal of Medicinal Chemistry, 2005, Roelens, Frederik et. al.
DNA sequence recognition in the minor groove by hairpin microgonotropens
score: 1.3535714, Bioorganic & Medicinal Chemistry Letters, 2006, Kahane, Alexandra L.; Bruice, Thomas C.
Artemisinin derivatives bearing Mannich base group: synthesis and antimalarial activity
score: 1.3534385, Bioorganic & Medicinal Chemistry, 2003, Li, Ying et. al.
Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics
score: 1.353424, Bioorganic & Medicinal Chemistry, 2006, Lundt, Inge et. al.
Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents
score: 1.3533787, European Journal of Medicinal Chemistry, 2010, Zhu, Shuren et. al.
Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.
score: 1.3533559, Antimicrobial agents and chemotherapy, 1998, Hawley, S R et. al.
Potent and Specific Inhibition of Human Leukocyte Elastase, Cathepsin G and Proteinase 3 by Sulfone Derivatives Employing the 1,2,5-Thiadiazolidin-3-one 1,1 Dioxide Scaffold
score: 1.3532198, Bioorganic & Medicinal Chemistry, 1998, Groutas, William C. et. al.
Binding analysis of glycyrrhetinic acid to human serum albumin: Fluorescence spectroscopy, FTIR, and molecular modeling
score: 1.3531696, Bioorganic & Medicinal Chemistry, 2006, Tang, Jianghong; Luan, Feng; Chen, Xingguo
Syntheses of [12]aneN3-oligopeptide conjugates as effective DNA condensation agents
score: 1.3531502, Bioorganic & Medicinal Chemistry, 2012, Li, Zhi-Fen et. al.
Evaluation of novel dipeptide-bound α,β-unsaturated amides and epoxides as irreversible inhibitors of guinea pig liver transglutaminase
score: 1.3530708, Bioorganic & Medicinal Chemistry, 2001, Marrano, Claudio; de Macédo, Pierre; Keillor, Jeffrey W.
A fast and robust 19F NMR-based method for finding new HIV-1 protease inhibitors
score: 1.3529452, Bioorganic & Medicinal Chemistry Letters, 2006, Frutos, Silvia; Tarrago, Teresa; Giralt, Ernest
[ 11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice
score: 1.3529282, Bioorganic & Medicinal Chemistry, 2005, Nabulsi, Nabeel B.; Smith, David E.; Kilbourn, Michael R.
Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines
score: 1.3529264, Bioorganic & Medicinal Chemistry, 2004, Satyanarayana, M et. al.
Valacyclovir
score: 1.3527228, Bioorganic & Medicinal Chemistry, 1996, Shinkai, Ichiro; Ohta, Yukari
The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite.
score: 1.3527149, Antimicrobial agents and chemotherapy, 1998, Rogers, M J; Cundliffe, E; McCutchan, T F
AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains.
score: 1.3526987, Antimicrobial agents and chemotherapy, 2011, Zamorano, Laura et. al.
Beta-carboline alkaloids derived from the ascidian Synoicum sp.
score: 1.3526082, Bioorganic & Medicinal Chemistry, 2012, Won, Tae Hyung et. al.
Beta-carboline alkaloids derived from the ascidian Synoicum sp.
score: 1.3526082, Bioorganic & Medicinal Chemistry, 2012, Won, Tae Hyung et. al.
The trifluoromethyl transformation synthesis, crystal structure and insecticidal activities of novel 2-pyrrolecarboxamide and 2-pyrrolecarboxlate
score: 1.3523984, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Yongqiang et. al.
Tyrosine analogues as alternative substrates for protein tyrosine kinase Csk: Insights into substrate selectivity and catalytic mechanism
score: 1.3523216, Bioorganic & Medicinal Chemistry, 2000, Kim, Kyonghee et. al.
Synthesis and biodistribution of a novel 99mTcN complex of ciprofloxacin dithiocarbamate as a potential agent for infection imaging
score: 1.3520952, Bioorganic & Medicinal Chemistry Letters, 2008, Zhang, Junbo et. al.
DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants.
score: 1.351929, Antimicrobial agents and chemotherapy, 2001, Kaltenbach, R F et. al.
Prediction of relative potency of ketone protease inhibitors using molecular orbital theory
score: 1.351802, Bioorganic & Medicinal Chemistry, 1996, Edith Chan, A.W.; Golec, Julian M.C.
Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains.
score: 1.3515323, Antimicrobial agents and chemotherapy, 2005, Sader, Helio S et. al.
Synthesis and biological evaluation of 2-(4-fluorophenoxy)-2-phenyl-ethyl piperazines as serotonin-selective reuptake inhibitors with a potentially improved adverse reaction profile
score: 1.351401, Bioorganic & Medicinal Chemistry, 2004, Dorsey, James M et. al.
Dual surface selection methodology for the identification of thrombin binding epitopes from hotspot biased phage-display libraries
score: 1.3513849, Bioorganic & Medicinal Chemistry Letters, 2004, Rajagopal, Srivats; Meza-Romero, Roberto; Ghosh, Indraneel
The crystal structure, self-assembly, DNA-binding and cleavage studies of the [2]pseudorotaxane composed of cucurbit[6]uril
score: 1.3513757, Bioorganic & Medicinal Chemistry Letters, 2007, Huo, Fang-Jun; Yin, Cai-Xia; Yang, Pin
Impurity analysis of retinoic acid samples
score: 1.3513589, Bioorganic & Medicinal Chemistry Letters, 2005, Allegrone, Gianna et. al.
Synthesis of PECAM-1-specific 64Cu PET imaging agent: Evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse
score: 1.3513122, Bioorganic & Medicinal Chemistry Letters, 2012, Xiao, Li et. al.
Synthesis of PECAM-1-specific 64Cu PET imaging agent: Evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse
score: 1.3513122, Bioorganic & Medicinal Chemistry Letters, 2012, Xiao, Li et. al.
Synthesis of PECAM-1-specific 64Cu PET imaging agent: Evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse
score: 1.3513122, Bioorganic & Medicinal Chemistry Letters, 2012, Xiao, Li et. al.
Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance.
score: 1.3511341, Antimicrobial agents and chemotherapy, 2003, Gross, Christian H et. al.
Preparation and fluorescence properties of fluorophore-labeled avidin–biotin system immobilized on Fe 3O 4 nanoparticles through functional indolequinone linker
score: 1.350977, Bioorganic & Medicinal Chemistry, 2009, Hirata, Nao et. al.
A preliminary investigation of Mesoionic Xanthine analogues as inhibitors of platelet aggregation
score: 1.3509478, Bioorganic & Medicinal Chemistry, 2000, Hellberg, Mark; Stubbins, James F.; Glennon, Richard A.
Novel potassium channel openers. Part 4: transformation of the 1,4-benzoxazine skeleton into 1,4-benzothiazine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroquinoxaline, indoline, and 1,5-benzoxazepine
score: 1.3508978, Bioorganic & Medicinal Chemistry, 2000, Matsumoto, Yuzo et. al.
Synthesis and antitumor activity of lapathoside D and its analogs
score: 1.3507912, European Journal of Medicinal Chemistry, 2012, Panda, Parthasarathi et. al.
Synthesis and antitumor activity of lapathoside D and its analogs
score: 1.3507912, European Journal of Medicinal Chemistry, 2012, Panda, Parthasarathi et. al.
Inhibition of myo-inositol monophosphatase isoforms by aromatic phosphonates
score: 1.3507061, Bioorganic & Medicinal Chemistry, 1998, Ganzhorn, Axel J. et. al.
Insights through AM1 calculations into the structural requirement of 3,4,6-substituted-2-quinolone analogs towards FMS kinase inhibitory activity
score: 1.3506169, European Journal of Medicinal Chemistry, 2010, Gupta, Arun Kumar et. al.
Oxinobactin, a siderophore analogue to enterobactin involving 8-hydroxyquinoline subunits: Synthesis and iron binding ability
score: 1.3506148, Bioorganic & Medicinal Chemistry Letters, 2008, du Moulinet d’Hardemare, Amaury et. al.
Structure–activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines
score: 1.3505353, Bioorganic & Medicinal Chemistry, 2010, Suhara, Yoshitomo et. al.
Anticonvulsant activity of artificial sweeteners: A structural link between sweet-taste receptor T1R3 and brain glutamate receptors
score: 1.350432, Bioorganic & Medicinal Chemistry Letters, 2012, Talevi, Alan; Enrique, Andrea; Bruno-Blanch, Luis E.
Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors
score: 1.350432, Bioorganic & Medicinal Chemistry Letters, 2012, Talevi, Alan; Enrique, Andrea; Bruno-Blanch, Luis E.
Anticonvulsant activity of artificial sweeteners: A structural link between sweet-taste receptor T1R3 and brain glutamate receptors
score: 1.350432, Bioorganic & Medicinal Chemistry Letters, 2012, Talevi, Alan; Enrique, Andrea V.; Bruno-Blanch, Luis E.
Anticonvulsant activity of artificial sweeteners: A structural link between sweet-taste receptor T1R3 and brain glutamate receptors
score: 1.350432, Bioorganic & Medicinal Chemistry Letters, 2012, Talevi, Alan; Enrique, Andrea V.; Bruno-Blanch, Luis E.
A novel 3D-QSAR comparative molecular field analysis (CoMFA) model of imidazole and quinazolinone functionalized p38 MAP kinase inhibitors
score: 1.3502782, Bioorganic & Medicinal Chemistry, 2004, Sperandio da Silva, Gilberto M. et. al.
Docking and quantum mechanic studies on cholinesterases and their inhibitors
score: 1.3502264, European Journal of Medicinal Chemistry, 2007, Correa-Basurto, José et. al.
Phenylhomophthalimide-type NOS inhibitors derived from thalidomide
score: 1.3501018, Bioorganic & Medicinal Chemistry Letters, 2004, Noguchi, Tomomi et. al.
Resin-supported catalytic dendrimers as multivalent artificial metallonucleases
score: 1.3499442, Bioorganic & Medicinal Chemistry Letters, 2009, Zaupa, Giovanni; Prins, Leonard J.; Scrimin, Paolo
Biphenyls as potential mimetics of protein α-helix
score: 1.3499052, Bioorganic & Medicinal Chemistry Letters, 2002, Jacoby, Edgar
Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine
score: 1.3497871, Bioorganic & Medicinal Chemistry Letters, 2005, Cadena-Amaro, Claudio; Delepierre, Muriel; Pochet, Sylvie
Conformational studies on resiniferatoxin (RTX), an ultrapotent vanilloid agonist
score: 1.3497769, Bioorganic & Medicinal Chemistry, 1998, Victory, Sam F; Appendino, Giovanni; Velde, David G.Vander
Bacterial diaminopimelate metabolism as a target for antibiotic design
score: 1.3497619, Bioorganic & Medicinal Chemistry, 2000, Cox, Russell J.; Sutherland, Andrew; Vederas, John C.
Degradation of target protein in living cells by small-molecule proteolysis inducer
score: 1.3496127, Bioorganic & Medicinal Chemistry Letters, 2004, Zhang, Dong; Baek, Sun-Hee; Ho, Abby; Kim, Kyungbo
Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide
score: 1.3496046, Bioorganic & Medicinal Chemistry Letters, 2006, Seridi, Achour et. al.
Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1 H-dihydropyrrolizine type
score: 1.3493785, European Journal of Medicinal Chemistry, 2002, Ulbrich, Holger; Fiebich, Bernd; Dannhardt, Gerd
Ptaquiloside Z, a new toxic unstable sesquiterpene glucoside from the neotropical bracken fern pteridium aquilinum var. caudatum
score: 1.3493735, Bioorganic & Medicinal Chemistry, 1998, Castillo, Uvidelio Francisco et. al.
An Artificial Cu II complex with intriguing oxygen radical-quenching profile. X-ray structure, cytochrome C assay, and ESR study
score: 1.3490862, Bioorganic & Medicinal Chemistry, 1996, Otsuka, Masami et. al.
Synthesis, Characterization and Biological Evaluation of 7α-Perfluoroalkylestradiol Derivatives
score: 1.3490303, Bioorganic & Medicinal Chemistry, 2003, Blazejewski, Jean-C1aude et. al.
Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457
score: 1.3490082, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Fa-Zuo et. al.
Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457
score: 1.3490082, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Fa-Zuo et. al.
Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457
score: 1.3490082, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Fa-Zuo et. al.
Trypanocidal activity of 5,6-dihydropyran-2-ones against free trypomastigotes forms of Trypanosoma cruzi
score: 1.3489312, European Journal of Medicinal Chemistry, 2006, de Fátima, Ângelo et. al.
Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax
score: 1.3488782, Bioorganic & Medicinal Chemistry, 2002, Jiang, Ren-Wang et. al.
Carnosic acid, a new class of lipid absorption inhibitor from sage
score: 1.3488329, Bioorganic & Medicinal Chemistry Letters, 2004, Ninomiya, Kiyofumi et. al.
Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics
score: 1.3488135, Bioorganic & Medicinal Chemistry Letters, 1999, Petitou, Maurice et. al.
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
score: 1.3487317, Bioorganic & Medicinal Chemistry, 2012, Ohtake, Yoshihito et. al.
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
score: 1.3487317, Bioorganic & Medicinal Chemistry, 2012, Ohtake, Yoshihito et. al.
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
score: 1.3487317, Bioorganic & Medicinal Chemistry, 2012, Ohtake, Yoshihito et. al.
Anti-inflammatory norditerpenoids from the soft coral Sinularia maxima
score: 1.3487091, Bioorganic & Medicinal Chemistry Letters, 2013, Thao, Nguyen Phuong et. al.
Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies
score: 1.3486068, Bioorganic & Medicinal Chemistry Letters, 2012, Gildersleeve, Jeffrey C. et. al.
Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies
score: 1.3486068, Bioorganic & Medicinal Chemistry Letters, 2012, Gildersleeve, Jeffrey C. et. al.
Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies
score: 1.3486068, Bioorganic & Medicinal Chemistry Letters, 2012, Gildersleeve, Jeffrey C. et. al.
Syntheses of [12]aneN3–oligopeptide conjugates as effective DNA condensation agents
score: 1.3483191, Bioorganic & Medicinal Chemistry, 2012, Li, Zhi-Fen et. al.
Syntheses of [12]aneN3–oligopeptide conjugates as effective DNA condensation agents
score: 1.3483191, Bioorganic & Medicinal Chemistry, 2012, Li, Zhi-Fen et. al.
A stable analog of isochorismate for the study of MenD and other isochorismate-utilizing enzymes
score: 1.3481517, Bioorganic & Medicinal Chemistry Letters, 2010, Fang, Maohai; Langman, Blaine M.; Palmer, David R.J.
A quantitative structure–activity relationship study on Clostridium histolyticum collagenase inhibitors
score: 1.3481161, Bioorganic & Medicinal Chemistry, 2003, Gupta, S.P.; Kumaran, S.
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A
score: 1.3481097, Bioorganic & Medicinal Chemistry Letters, 2013, Dolušić, Eduard et. al.
Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles
score: 1.3480487, European Journal of Medicinal Chemistry, 2012, Moineaux, Laurence et. al.
Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles
score: 1.3480487, European Journal of Medicinal Chemistry, 2012, Moineaux, Laurence et. al.
Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis.
score: 1.3480316, Antimicrobial agents and chemotherapy, 2011, Kapoor, Rinki et. al.
Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains.
score: 1.3479529, Antimicrobial agents and chemotherapy, 1998, Srinivas, R V; Fridland, A
Quantitative structure–activity relationship studies on HEPTs by supervised stochastic resonance
score: 1.3478842, Bioorganic & Medicinal Chemistry Letters, 2006, Guo, Weimin; Hu, Xiaofang; Chu, Ningping; Yin, Chunsheng
A novel method for the preparation of amino-substituted hypocrellin B
score: 1.3477948, Bioorganic & Medicinal Chemistry Letters, 2001, Xu, Shangjie; Chen, Shen; Zhang, Manhua; Shen, Tao
The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets
score: 1.3474804, Bioorganic & Medicinal Chemistry, 2006, Legraverend, Michel; Grierson, David S.
Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents
score: 1.3474628, Bioorganic & Medicinal Chemistry Letters, 2012, Bacharaju, Keerthana et. al.
Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents
score: 1.3474628, Bioorganic & Medicinal Chemistry Letters, 2012, Bacharaju, Keerthana et. al.
Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents
score: 1.3474628, Bioorganic & Medicinal Chemistry Letters, 2012, Bacharaju, Keerthana et. al.
Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China.
score: 1.3474027, Antimicrobial agents and chemotherapy, 2003, Wang, Minggui et. al.
Solution conformations of amphidinolide H
score: 1.3473673, Bioorganic & Medicinal Chemistry, 2005, Shimbo, Kazutaka et. al.
Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin–dextran as a novel MRI contrast agent
score: 1.3473051, Bioorganic & Medicinal Chemistry Letters, 2009, Zhang, Zhi et. al.
5′-Amino-5′-deoxyaristeromycin and its antiviral properties
score: 1.347193, Bioorganic & Medicinal Chemistry, 2003, Rajappan, Vasanthakumar P; Schneller, Stewart W
Single bead ir monitoring of a novel benzimidazole synthesis
score: 1.3471821, Bioorganic & Medicinal Chemistry Letters, 1998, Sun, Qun; Yan, Bing
Self-calibrating viscosity probes: Design and subcellular localization
score: 1.3471427, Bioorganic & Medicinal Chemistry, 2012, Dakanali, Marianna et. al.
Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome.
score: 1.3471157, Antimicrobial agents and chemotherapy, 2011, Newman, Zachary L et. al.
Polymer supported carbodiimide strategy for the synthesis of N-acylated derivatives of deoxy- and ribo purinenucleosides using active esters
score: 1.3470314, Bioorganic & Medicinal Chemistry Letters, 2005, Tripathi, Snehlata; Misra, Krishna; Sanghvi, Yogesh S.
Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: generating an antibiotic bar code.
score: 1.3469052, Antimicrobial agents and chemotherapy, 2010, Liu, Anne et. al.
Synthesis and aldose reductase inhibitory activities of novel N-nitromethylsulfonanilide derivatives
score: 1.3468849, Bioorganic & Medicinal Chemistry, 2000, Inoue, Jun et. al.
Design, synthesis, biological evaluation and molecular modeling of novel 1,3,4-oxadiazole derivatives based on Vanillic acid as potential immunosuppressive agents
score: 1.3468817, Bioorganic & Medicinal Chemistry, 2012, Tang, Jian-Feng et. al.
Design, synthesis, biological evaluation and molecular modeling of novel 1,3,4-oxadiazole derivatives based on Vanillic acid as potential immunosuppressive agents
score: 1.3468817, Bioorganic & Medicinal Chemistry, 2012, Tang, Jian-Feng et. al.
Physicochemical prediction of a brain–blood distribution profile in polycyclic amines
score: 1.3467921, Bioorganic & Medicinal Chemistry, 2003, Zah, Jaco et. al.
Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat
score: 1.3467322, Bioorganic & Medicinal Chemistry, 2006, Zhou, Longhu et. al.
Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil–isatin conjugates and their cytotoxic evaluation
score: 1.3467295, European Journal of Medicinal Chemistry, 2012, Kumar, Kewal et. al.
Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil–isatin conjugates and their cytotoxic evaluation
score: 1.3467295, European Journal of Medicinal Chemistry, 2012, Kumar, Kewal et. al.
Modification of constrained peptides by ring-closing metathesis reaction
score: 1.3466847, Bioorganic & Medicinal Chemistry Letters, 2001, Kotha, Sambasivarao et. al.
G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay
score: 1.3466394, Bioorganic & Medicinal Chemistry, 2012, Schoonover, Michelle; Kerwin, Sean M.
G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay
score: 1.3466394, Bioorganic & Medicinal Chemistry, 2012, Schoonover, Michelle; Kerwin, Sean M.
G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay
score: 1.3466394, Bioorganic & Medicinal Chemistry, 2012, Schoonover, Michelle; Kerwin, Sean M.
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells
score: 1.3464965, Bioorganic & Medicinal Chemistry Letters, 2012, Hoang, Minh-Hien et. al.
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells
score: 1.3464965, Bioorganic & Medicinal Chemistry Letters, 2012, Hoang, Minh-Hien et. al.
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells
score: 1.3464965, Bioorganic & Medicinal Chemistry Letters, 2012, Hoang, Minh-Hien et. al.
Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim.
score: 1.346427, Antimicrobial agents and chemotherapy, 2004, Barrow, Esther W; Bourne, Philip C; Barrow, William W
Pharmacophore modeling, resistant mutant isolation, docking, and MM-PBSA analysis: Combined experimental/computer-assisted approaches to identify new inhibitors of the bovine viral diarrhea virus (BVDV)
score: 1.3463813, Bioorganic & Medicinal Chemistry, 2010, Tonelli, Michele et. al.
Syntheses and Biological Evaluations of α- d-Mannosyl [60]fullerenols
score: 1.3461464, Bioorganic & Medicinal Chemistry Letters, 2001, Kato, Haruhito et. al.
MR contrast agent composed of cholesterol and peptide nucleic acids: Design, synthesis and cellular uptake
score: 1.3461152, Bioorganic & Medicinal Chemistry Letters, 2010, Joshi, Rajendra et. al.
Utilization of [11C]phosgene for radiosynthesis of N-(2-{3-[3,5-bis(trifluoromethyl)]phenyl[11C]ureido}ethyl)glycyrrhetinamide, an inhibitory agent for proteasome and kinase in tumors
score: 1.3461031, Bioorganic & Medicinal Chemistry Letters, 2012, Asakawa, Chiharu et. al.
P-selectin blocking potency of multimeric tyrosine sulfates in vitro and in vivo
score: 1.3460049, Bioorganic & Medicinal Chemistry Letters, 2003, Pochechueva, Tatyana V et. al.
Small molecules that regulate zymosan phagocytosis of macrophage through deactivation of Rho GTPases
score: 1.3459686, Bioorganic & Medicinal Chemistry, 2012, Bang, Joon Seok et. al.
Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia
score: 1.3459036, Bioorganic & Medicinal Chemistry Letters, 2002, Zheng, Gang et. al.
A carbosilane dendrimer and a silacyclopentadiene analog carrying peripheral lactoses as drug-delivery systems
score: 1.345849, Bioorganic & Medicinal Chemistry Letters, 2012, Aizawa, Hiroaki et. al.
Synthesis and antiviral activity evaluation of novel 2-phenyl-4-( d- arabino-4′-cycloaminobutyl)triazoles: acyclonucleosides containing unnatural bases
score: 1.345835, Bioorganic & Medicinal Chemistry, 2002, Himanshu, ?. et. al.
Fatty acid amide signaling molecules
score: 1.3458213, Bioorganic & Medicinal Chemistry Letters, 2010, Ezzili, Cyrine; Otrubova, Katerina; Boger, Dale L.
Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY prepared via Click Chemistry: Synthesis and biological evaluation
score: 1.3457653, Bioorganic & Medicinal Chemistry, 2012, Papst, Stefanie et. al.
A double catgrip mixed l and d mini protein only 20 residues long
score: 1.3457621, Bioorganic & Medicinal Chemistry, 2007, Rana, Soumendra; Kundu, Bijoy; Durani, Susheel
Anucleate cell blue assay: a useful tool for identifying novel type II topoisomerase inhibitors.
score: 1.3455945, Antimicrobial agents and chemotherapy, 2006, Oyamada, Yoshihiro et. al.
Fluorinated phenylcyclopropylamines. Part 3: Inhibition of monoamine oxidase A and B
score: 1.3455924, Bioorganic & Medicinal Chemistry, 2004, Yoshida, Shinichi et. al.
ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity
score: 1.3455198, Bioorganic & Medicinal Chemistry, 2003, Ghelli, Stefano et. al.
QSAR and kinetics of the inhibition of benzaldehyde derivatives against Sacrophaga neobelliaria phenoloxidase
score: 1.3455005, Bioorganic & Medicinal Chemistry, 2004, Li, Wei; Kubo, Isao
Effect of change in nucleoside structure on the activation and antiviral activity of phosphoramidate derivatives
score: 1.3454426, Bioorganic & Medicinal Chemistry, 2005, Venkatachalam, T.K.; Samuel, P.; Qazi, S.; Uckun, F.M.
Glucose-6-phosphatase Catalytic Enzyme Inhibitors: Synthesis and In Vitro Evaluation of Novel 4,5,6,7-Tetrahydrothieno[3,2- c]- and -[2,3- c]pyridines
score: 1.3453173, Bioorganic & Medicinal Chemistry, 2000, Madsen, Peter et. al.
Synthesis and structure activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents
score: 1.3451156, Bioorganic & Medicinal Chemistry, 2012, Yamazaki, Yuri et. al.
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.
score: 1.3450315, Antimicrobial agents and chemotherapy, 2006, Biagini, Giancarlo A et. al.
Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage
score: 1.3446971, Bioorganic & Medicinal Chemistry, 2004, Ru Hwu, Jih et. al.
Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[ g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents
score: 1.3446588, Bioorganic & Medicinal Chemistry, 2006, Tandon, Vishnu K. et. al.
Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
score: 1.3446028, Bioorganic & Medicinal Chemistry, 2012, Mokale, Santosh N.; Lokwani, Deepak; Shinde, Devanand B.
Synthesis and in vivo evaluation of Tc-99m-labeled cyclic C isoDGRC peptide conjugates for targeting α vβ 3 integrin expression
score: 1.344583, Bioorganic & Medicinal Chemistry Letters, 2010, Pathuri, Gopal et. al.
Lipid A structures containing novel lipid moieties: synthesis and adjuvant properties
score: 1.3443074, Bioorganic & Medicinal Chemistry Letters, 2002, Jiang, Zi-Hua et. al.
MK-4815, a potential new oral agent for treatment of malaria.
score: 1.3442933, Antimicrobial agents and chemotherapy, 2012, Powles, Mary Ann et. al.
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents
score: 1.3442673, Bioorganic & Medicinal Chemistry Letters, 2005, Kim, Tae-Hyuk; Kuca, Kamil; Jun, Daniel; Jung, Young-Sik
Continuing efforts on the improvement of Beckmann rearrangement of indanone oxime
score: 1.3440025, Bioorganic & Medicinal Chemistry Letters, 2007, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-Fused area and the difference in spectra, photochemistry and photobiological activity
score: 1.3438687, Bioorganic & Medicinal Chemistry, 2003, Xu, Yufang; Qian, Xuhong; Yao, Wei; Mao, Ping; Cui, Jingnan
Synthesis and antibacterial activity of novel C 12 ethyl ketolides
score: 1.3438656, Bioorganic & Medicinal Chemistry, 2006, Burger, Matthew T. et. al.
2- C-Methyluridine modified hammerhead ribozyme against the estrogen receptor
score: 1.3437905, Bioorganic & Medicinal Chemistry Letters, 2010, Pontiggia, Rodrigo et. al.
Synthesis and biological evaluation of α-methylidene-δ-lactones with 3,4-dihydrocoumarin skeleton
score: 1.3437706, Bioorganic & Medicinal Chemistry, 2012, Modranka, Jakub et. al.
High transfection efficiency and low toxicity cationic lipids with aminoglycerol–diamine conjugate
score: 1.3437487, Bioorganic & Medicinal Chemistry, 2009, Yingyongnarongkul, Boon-ek et. al.
Synthesis of Tc-99m labeled glucosamino-Asp-cyclic(Arg-Gly-Asp- d-Phe-Lys) as a potential angiogenesis imaging agent
score: 1.3436611, Bioorganic & Medicinal Chemistry, 2007, Lee, Byung Chul et. al.
Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: Their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations
score: 1.3436245, Bioorganic & Medicinal Chemistry, 2006, André, Sabine et. al.
Antimalarial activities of peptide antibiotics isolated from fungi.
score: 1.3435661, Antimicrobial agents and chemotherapy, 2001, Nagaraj, G; Uma, M V; Shivayogi, M S; Balaram, H
Tachykinin NK-1 receptor probed with constrained analogues of substance P
score: 1.343534, Bioorganic & Medicinal Chemistry, 1996, Sagan, Sandrine et. al.
Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4
score: 1.3434139, Bioorganic & Medicinal Chemistry, 2006, Row, E.C.; Brown, S.A.; Stachulski, A.V.; Lennard, M.S.
Clinical pharmacokinetics of alamifovir and its metabolites.
score: 1.3433093, Antimicrobial agents and chemotherapy, 2005, Chan, Clark et. al.
Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group
score: 1.3432791, European Journal of Medicinal Chemistry, 2001, Ciobanu, Liviu C et. al.
Synthesis and carbohydrate binding studies of fluorescent α-amidoboronic acids and the corresponding bisboronic acids
score: 1.343242, Bioorganic & Medicinal Chemistry, 2010, Jin, Shan et. al.
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine
score: 1.3431537, Bioorganic & Medicinal Chemistry, 2012, Brunhofer, Gerda et. al.
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine
score: 1.3431537, Bioorganic & Medicinal Chemistry, 2012, Brunhofer, Gerda et. al.
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine
score: 1.3431537, Bioorganic & Medicinal Chemistry, 2012, Brunhofer, Gerda et. al.
Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors
score: 1.3431122, European Journal of Medicinal Chemistry, 2010, Chen, Wu et. al.
Identification of benzoylisoquinolines as potential anti-Chagas agents
score: 1.343058, Bioorganic & Medicinal Chemistry, 2012, Byler, Kendall G. et. al.
Engineering non-natural inhibitor sensitivity in protein tyrosine phosphatase H1
score: 1.3428434, Bioorganic & Medicinal Chemistry, 2006, Blair, Elizabeth R.; Hoffman, Hillary E.; Bishop, Anthony C.
In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum.
score: 1.3428247, Antimicrobial agents and chemotherapy, 2012, Joanny, Fanny; Held, Jana; Mordmüller, Benjamin
Antiviral activity of (+)-sattabacin against varicella zoster
score: 1.3427388, Bioorganic & Medicinal Chemistry Letters, 2013, Mancha, Serena R. et. al.
Synergistic effects between aminoethyl-chitosans and β-lactams against methicillin-resistant Staphylococcus aureus (MRSA)
score: 1.3426432, Bioorganic & Medicinal Chemistry Letters, 2010, Lee, Dae-Sung et. al.
Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors
score: 1.3426057, Bioorganic & Medicinal Chemistry, 2005, Abe, Masatoshi et. al.
Oligonucleotides bearing 5-Formyl-2′- O-methyluridine: Preference in binding affinity to the NF-κB (p50) 2 homo- and p50/p65 heterodimers
score: 1.3424946, Bioorganic & Medicinal Chemistry Letters, 1998, Kittaka, Atsushi et. al.
A simple method for predicting serum protein binding of compounds from IC 50 shift analysis for in vitro assays
score: 1.3424525, Bioorganic & Medicinal Chemistry Letters, 2004, Rusnak, David W. et. al.
The synthesis of three 4-substitutedbenzo[ b]thiophene-2-carboxamidines as potent and selective inhibitors of urokinase
score: 1.3424018, Bioorganic & Medicinal Chemistry, 1993, Bridges, Alexander J. et. al.
Heterocyclic analogues of l-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N δ-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor
score: 1.3422148, Bioorganic & Medicinal Chemistry, 1999, Ulhaq, Saraj et. al.
Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities
score: 1.3420938, Bioorganic & Medicinal Chemistry, 2006, Akamatsu, Masao et. al.
Anti-leukemia selectivity in actinomycin analogues
score: 1.3420356, Bioorganic & Medicinal Chemistry, 2001, Takusagawa, Fusao; Carlson, Robert G; Weaver, Robert F
[1,2,4]Triazole derivatives as 5-HT 1A serotonin receptor ligands
score: 1.3420204, Bioorganic & Medicinal Chemistry, 2002, Sarvà, Maria Concetta et. al.
Syntheses of 1- deoxy-3-S-(1- thio-α- d-glucopyranosyl)-mannojirimycin and 1- deoxy-3-O-(5- thio-α- d-glucopyranosyl)-mannojirimycin as potential inhibitors of endo-α- d-mannosidase
score: 1.3417408, Bioorganic & Medicinal Chemistry Letters, 1998, Ding, Yili; Hindsgaul, Ole
Quantitative structure–activity relationship analyses of antioxidant and free radical scavenging activities for hydroxybenzalacetones
score: 1.3416858, Bioorganic & Medicinal Chemistry Letters, 2004, Yamagami, Chisako et. al.
Specific interactions between adenosine and streptavidin/avidin
score: 1.3416812, Bioorganic & Medicinal Chemistry Letters, 2012, Bing, Tao et. al.
Specific interactions between adenosine and streptavidin/avidin
score: 1.3416812, Bioorganic & Medicinal Chemistry Letters, 2012, Bing, Tao et. al.
Specific interactions between adenosine and streptavidin/avidin
score: 1.3416812, Bioorganic & Medicinal Chemistry Letters, 2012, Bing, Tao et. al.
Highly hydroxylated or γ-cyclodextrin-bicapped water-soluble derivative of fullerene: The antioxidant ability assessed by electron spin resonance method and β-carotene bleaching assay
score: 1.3414776, Bioorganic & Medicinal Chemistry Letters, 2009, Kato, Shinya et. al.
Polymerase incorporation of pyrene-nucleoside triphosphates
score: 1.3414223, Bioorganic & Medicinal Chemistry Letters, 2012, Hollenstein, Marcel et. al.
Polymerase incorporation of pyrene-nucleoside triphosphates
score: 1.3414223, Bioorganic & Medicinal Chemistry Letters, 2012, Hollenstein, Marcel et. al.
Polymerase incorporation of pyrene-nucleoside triphosphates
score: 1.3414223, Bioorganic & Medicinal Chemistry Letters, 2012, Hollenstein, Marcel et. al.
Conformationally restricted TRH analogues
score: 1.3413943, Bioorganic & Medicinal Chemistry, 2002, Simpson, Jill C. et. al.
Synthesis, immunomodulating activity and 1H NMR studies of 7-oxo-9,11-ethano-13-azaprostanoids
score: 1.3413403, European Journal of Medicinal Chemistry, 2004, Bondar, Natalia F. et. al.
Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy- D- arabino-heptulosonate 7-phosphate synthase
score: 1.3412497, Bioorganic & Medicinal Chemistry Letters, 2005, Williamson, Rachel M. et. al.
Benzofuran based PDE4 inhibitors
score: 1.3409356, Bioorganic & Medicinal Chemistry, 1999, McGarry, D.G et. al.
Importance of position 170 in the inhibition of GES-type β-lactamases by clavulanic acid.
score: 1.3407796, Antimicrobial agents and chemotherapy, 2011, Frase, Hilary et. al.
Synthesis and biological activities of fluorinated chalcone derivatives
score: 1.3406326, Bioorganic & Medicinal Chemistry, 2002, Nakamura, Chika et. al.
Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles
score: 1.3406113, Bioorganic & Medicinal Chemistry Letters, 2013, Kasten, Benjamin B. et. al.
The synthesis and antibacterial activity of totarol derivatives. part 2: modifications at C-12 and O-13
score: 1.3405482, Bioorganic & Medicinal Chemistry, 2000, Evans, Gary B; Furneaux, Richard H
Nucleotide libraries as a source of biologically relevant chemical diversity: solution-phase synthesis
score: 1.3404729, Bioorganic & Medicinal Chemistry Letters, 2000, Zhou, Wenqiang et. al.
Impact of granulocytes on the antimicrobial effect of tedizolid in a mouse thigh infection model.
score: 1.3403776, Antimicrobial agents and chemotherapy, 2011, Drusano, G L; Liu, Weiguo; Kulawy, Robert; Louie, Arnold
The controlled introduction of multiple negative charge at single amino acid sites in subtilisin Bacillus lentus
score: 1.3403398, Bioorganic & Medicinal Chemistry, 1999, Davis, Benjamin G. et. al.
N γ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site
score: 1.3402719, Bioorganic & Medicinal Chemistry, 2005, Esslinger, C. Sean et. al.
Development of pH-responsive core–shell nanocarriers for delivery of therapeutic and diagnostic agents
score: 1.3402371, Bioorganic & Medicinal Chemistry Letters, 2009, Xu, Shangjie et. al.
Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation
score: 1.3400812, Bioorganic & Medicinal Chemistry, 2006, Tao, Haiyan et. al.
Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b
score: 1.3399792, Bioorganic & Medicinal Chemistry, 2006, Liu, Haitian; Wong, Chi-Huey
Synthesis of 9-oxime-11,12-carbamate ketolides Through a novel N-deamination reaction of 11,12-hydrazonocarbamate ketolide
score: 1.3397349, Bioorganic & Medicinal Chemistry, 2003, Denis, Alexis et. al.
2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazoles: Search for anticancer agents
score: 1.3396965, European Journal of Medicinal Chemistry, 2012, Noolvi, Malleshappa N. et. al.
2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazoles: Search for anticancer agents
score: 1.3396965, European Journal of Medicinal Chemistry, 2012, Noolvi, Malleshappa N. et. al.
Synthesis and biological activities of some new dibenzopyranones and dibenzopyrans: search for potential oestrogen receptor agonists and antagonists
score: 1.3394407, Bioorganic & Medicinal Chemistry, 2004, Pandey, Jaya; Jha, Ashok K; Hajela, K
An enantioselective synthesis of (+)-( S)-[ n]-gingerols via the l-proline-catalyzed aldol reaction
score: 1.3393553, Bioorganic & Medicinal Chemistry Letters, 2009, Ma, Shichao; Zhang, Shilei; Duan, Wenhu; Wang, Wei
Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine
score: 1.339303, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Soon Goo; Alpert, Tara D.; Jez, Joseph M.
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.
score: 1.3392698, Antimicrobial agents and chemotherapy, 2010, Llano-Sotelo, Beatriz et. al.
N-phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)
score: 1.3392439, Bioorganic & Medicinal Chemistry, 2012, Sabbah, Dima A. et. al.
Synthesis and properties of 2′- O-Methyl-2-thiouridine and oligoribonucleotides containing 2′- O-Methyl-2-thiouridine
score: 1.3391967, Bioorganic & Medicinal Chemistry Letters, 2000, Shohda, Koh-ichiroh et. al.
Synthesis, Characterization and Antiamoebic Activity of Benzimidazole Derivatives and Their Vanadium and Molybdenum Complexes
score: 1.3391502, Bioorganic & Medicinal Chemistry Letters, 2002, Bharti, Neelam et. al.
Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library
score: 1.3391189, Bioorganic & Medicinal Chemistry Letters, 2012, Whitby, Landon R. et. al.
Synthesis, characterization and in vitro anti-amoebic activity of new palladium(II) complexes with 5-nitrothiophene-2-carboxaldehyde N(4)-substituted thiosemicarbazones
score: 1.3390508, Bioorganic & Medicinal Chemistry, 2004, Bharti, Neelam et. al.
Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[18F]fluoro-myo-inositol
score: 1.3390461, Bioorganic & Medicinal Chemistry Letters, 2012, Carroll, Laurence et. al.
Synthesis, crystal structure and anticancer activity of novel derivatives of ethyl 1-(4-oxo-8-aryl-4,6,7,8-tetrahydroimidazo[2,1- c][1,2,4]triazin-3-yl)formate
score: 1.3389749, European Journal of Medicinal Chemistry, 2006, Sztanke, Krzysztof et. al.
3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents
score: 1.3388254, European Journal of Medicinal Chemistry, 2012, Plsikova, Jana et. al.
Synthesis, spectroscopic properties and protein labeling of water soluble 3,5-disubstituted boron dipyrromethenes
score: 1.338703, Bioorganic & Medicinal Chemistry Letters, 2009, Dilek, Özlem; Bane, Susan L.
Perchlorotrityl radical-fluorophore conjugates as dual fluorescence and EPR probes for superoxide radical anion
score: 1.338687, Bioorganic & Medicinal Chemistry, 2010, Wang, Jinhua et. al.
Hexose keto-C-glycoside conjugates: design, synthesis, cytotoxicity, and evaluation of their affinity for the glucose transporter glut-1
score: 1.338622, Bioorganic & Medicinal Chemistry, 1996, Uriel, Clara et. al.
Synthesis of 9-β- d-arabinofuranosylguanine by combined use of two whole cell biocatalysts
score: 1.3385736, Bioorganic & Medicinal Chemistry Letters, 2009, Médici, Rosario et. al.
Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic Probes for glycosyltransferases
score: 1.3385477, Bioorganic & Medicinal Chemistry, 2000, Burkart, Michael D et. al.
Newly synthesized dihydropyridine derivatives as modulators of P-Glycoprotein-mediated multidrug resistance
score: 1.3383012, Bioorganic & Medicinal Chemistry, 1998, Tanabe, Hirokazu et. al.
Synthesis, and biological evaluation of new 1,3,4-thiadiazolium-2-phenylamine derivatives against Leishmania amazonensis promastigotes and amastigotes
score: 1.3380931, European Journal of Medicinal Chemistry, 2002, da Silva, Edson F et. al.
Alcohol absorption inhibitors from bay leaf ( Laurus nobilis): structure-requirements of sesquiterpenes for the activity
score: 1.3379819, Bioorganic & Medicinal Chemistry, 2000, Yoshikawa, Masayuki et. al.
Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands (( R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons
score: 1.337964, Bioorganic & Medicinal Chemistry, 2005, Lin, Kuo-Shyan; Ding, Yu-Shin
Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor
score: 1.3379312, European Journal of Medicinal Chemistry, 2012, Leal, Carla Moreira et. al.
Cytotoxic activity of aminoderivatized cationic chitosan derivatives
score: 1.337643, Bioorganic & Medicinal Chemistry Letters, 2002, Lee, Jung-Kul; Lim, Hyun-Soo; Kim, Jung-Hoe
Antimycoplasmal activity of hydroxytyrosol.
score: 1.3375739, Antimicrobial agents and chemotherapy, 2004, Furneri, Pio Maria et. al.
Potent bacteriolytic activity of ritipenem associated with a characteristic profile of affinities for penicillin-binding proteins of Haemophilus influenzae.
score: 1.3375602, Antimicrobial agents and chemotherapy, 1999, Inui, T; Oshida, T; Endo, T; Matsushita, T
Inhibitory effect of novel S,N-bisphosphonates on some carcinoma cell lines, osteoarthritis, and chronic inflammation
score: 1.3374492, European Journal of Medicinal Chemistry, 2012, Kamel, Azza A.; Geronikaki, Athina; Abdou, Wafaa M.
Inhibitory effect of novel S,N-bisphosphonates on some carcinoma cell lines, osteoarthritis, and chronic inflammation
score: 1.3374492, European Journal of Medicinal Chemistry, 2012, Kamel, Azza A.; Geronikaki, Athina; Abdou, Wafaa M.
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 Integrase Inhibitors
score: 1.3373753, Bioorganic & Medicinal Chemistry Letters, 2012, Zhao, Xue Zhi et. al.
Structural determinants of substrates and inhibitors: probing glutamate transporters with 2,4-methanopyrroldidine-2,4-dicarboxylate
score: 1.337365, Bioorganic & Medicinal Chemistry Letters, 1998, Sean Esslinger, C. et. al.
Coomassie blue is sufficient for specific protein detection of aptamer-conjugated chips
score: 1.3372487, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Gwan-Ho; Hah, Sang Soo
Synthesis of five enantiomerically pure haptens designed for in vitro evolution of antibodies with peptidase activity
score: 1.3369085, Bioorganic & Medicinal Chemistry, 1996, Wagner, Jürgen; Lerner, Richard A.; Barbas, Carlos F.
Voltage-dependent ion channel formation by rigid rod-shaped polyols in planar lipid bilayers
score: 1.3367994, Bioorganic & Medicinal Chemistry Letters, 1998, Sakai, Naomi et. al.
Single-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers.
score: 1.3367567, Antimicrobial agents and chemotherapy, 2004, Schmitt-Hoffmann, Anne et. al.
Nucleic acid triggered catalytic drug and probe release: A new concept for the design of chemotherapeutic and diagnostic agents
score: 1.3367369, Bioorganic & Medicinal Chemistry, 2001, Ma, Zhaochun; Taylor, John-Stephen
Synthesis and in vitro antimicrobial activities of 2-hydroxy-6-methyl-7-(arylamino)-1,7-dihydropurin-8-ones
score: 1.3367263, Bioorganic & Medicinal Chemistry, 2004, Sharma, Pratibha; Sharma, Shikha; Rane, Nilesh
Synthesis and Cytotoxicity of Methyl-4,8-dihydrobenzo[1,2- b:5,4- b′]dithiophene-4,8-dione Derivatives
score: 1.3367146, Bioorganic & Medicinal Chemistry, 1999, Chao, Yu-Hua et. al.
Ester and carbamate ester derivatives of Biochanin A: Synthesis and in vitro evaluation of estrogenic and antiproliferative activities
score: 1.3365081, Bioorganic & Medicinal Chemistry, 2012, Fokialakis, Nikolas et. al.
A minimalistic approach to identify substrate binding features in B1 Metallo-β-lactamases
score: 1.3363496, Bioorganic & Medicinal Chemistry Letters, 2007, Poeylaut-Palena, Andrés A. et. al.
In vitro antibacterial activity of LJC 11,036, an active metabolite of L-084, a new oral carbapenem antibiotic with potent antipneumococcal activity.
score: 1.3361899, Antimicrobial agents and chemotherapy, 1999, Hikida, M; Itahashi, K; Igarashi, A; Shiba, T; Kitamura, M
Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation
score: 1.3360503, Bioorganic & Medicinal Chemistry, 2004, Demin, Peter et. al.
Stereoselective inhibition of glutamate carboxypeptidase by organophosphorus derivatives of glutamic acid
score: 1.3359816, Bioorganic & Medicinal Chemistry, 2004, Mallari, Jeremy P. et. al.
Synthesis of stable isotope labelled internal standards for drug–drug interaction (DDI) studies
score: 1.3359803, Bioorganic & Medicinal Chemistry, 2012, Atzrodt, J. et. al.
Thiophilic ring-opening and rearrangement reactions of epoxyketone natural products
score: 1.3359434, Bioorganic & Medicinal Chemistry Letters, 1998, Wipf, Peter; Jeger, Patrick; Kim, Yuntae
Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds.
score: 1.335911, Antimicrobial agents and chemotherapy, 2006, Nosanchuk, Joshua D; Casadevall, Arturo
Synthetic libraries of tyrosine-derived bacterial metabolites
score: 1.3358085, Bioorganic & Medicinal Chemistry Letters, 2008, Georgiades, Savvas N.; Clardy, Jon
Proof that the actVI genetic region of Streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin
score: 1.3357181, Bioorganic & Medicinal Chemistry Letters, 1999, Ichinose, Koji et. al.
Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity
score: 1.3356877, Bioorganic & Medicinal Chemistry, 2012, Li, Xi et. al.
A micromethod for the stereochemical analysis of fatty acid desaturase-mediated sulfoxidation reactions
score: 1.3356844, Bioorganic & Medicinal Chemistry Letters, 2005, Lao, Kim Y.Y. et. al.
Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro.
score: 1.3356802, Antimicrobial agents and chemotherapy, 2002, Levine, S et. al.
Liquid-Phase combinatorial synthesis of aminobenzimidazoles
score: 1.335651, Bioorganic & Medicinal Chemistry Letters, 2002, Huang, Kuo-Ting; Sun, Chung-Ming
Antiinflammatory Property of 3-Aryl-5-( n-propyl)-1,2,4-oxadiazoles and Antimicrobial Property of 3-Aryl-5-( n-propyl)-4,5-dihydro-1,2,4-oxadiazoles: Their Syntheses and Spectroscopic Studies
score: 1.3355537, Bioorganic & Medicinal Chemistry, 2003, Srivastava, Rajendra M et. al.
Trypanocidal agents with low cytotoxicity to mammalian cell line: A comparison of the theoretical and biological features of lapachone derivatives
score: 1.3354957, Bioorganic & Medicinal Chemistry, 2006, Ferreira, Vitor F. et. al.
Acenaphtho[1,2- b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity
score: 1.3353743, Bioorganic & Medicinal Chemistry, 2006, Zhang, Zhichao et. al.
Recognition of 2′-deoxy isoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases
score: 1.3353203, Bioorganic & Medicinal Chemistry Letters, 1998, Lutz, Michael J.; Horlacher, Jennifer; Benner, Steven A.
Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers
score: 1.3352284, Bioorganic & Medicinal Chemistry, 1998, Gordeev, Mikhail F. et. al.
Imidazo[2,1- b]thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding
score: 1.3352216, European Journal of Medicinal Chemistry, 2004, Kieć-Kononowicz, Katarzyna et. al.
Methoxychalcone inhibitors of androgen receptor translocation and function
score: 1.3351542, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Yeong Sang et. al.
Alkoxyamino glycoside acceptors for the regioselective synthesis of oligosaccharides using glycosynthases and transglycosidases
score: 1.3347854, Bioorganic & Medicinal Chemistry Letters, 2013, Teze, David et. al.
Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variants.
score: 1.3343797, Antimicrobial agents and chemotherapy, 2012, García-Fernández, Aurora et. al.
A facile synthesis of d-glucose-type gem-diamine 1- N-iminosugars: a new family of glucosidase inhibitors
score: 1.3343618, Bioorganic & Medicinal Chemistry, 1999, Shitara, Eiki et. al.
Synthesis of aminoglycoside–DNA conjugates
score: 1.3343276, Bioorganic & Medicinal Chemistry Letters, 2002, Charles, I.; Xue, Liang; Arya, Dev P.
A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells
score: 1.3342676, Bioorganic & Medicinal Chemistry Letters, 2008, Albers, Aaron E. et. al.
Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis.
score: 1.3341876, Antimicrobial agents and chemotherapy, 2011, Akshay, Subramanian et. al.
Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands
score: 1.3341858, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands
score: 1.3341858, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands
score: 1.3341858, Bioorganic & Medicinal Chemistry Letters, 2012, Nirogi, Ramakrishna V.S. et. al.
Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists
score: 1.3338241, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Lingyun et. al.
Antimalarial sulfide, sulfone, and sulfonamide trioxanes
score: 1.3337347, Bioorganic & Medicinal Chemistry, 2000, Posner, Gary H. et. al.
Biological activity studies on metal complexes of novel tridentate Schiff base ligand. Spectroscopic and thermal characterization
score: 1.3336317, European Journal of Medicinal Chemistry, 2009, Mohamed, Gehad G.; Omar, M.M.; Ibrahim, Amr A.
Synthesis of Novel Octa-cationic and Non-ionic 1, 2-ethanediamine Substituted Zinc (Ⅱ) Phthalocyanines and Their In Vitro Anti-cancer Activity Comparison
score: 1.3336203, European Journal of Medicinal Chemistry, 2012, Wang, Ao et. al.
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.
score: 1.3335437, Antimicrobial agents and chemotherapy, 2011, Ward, Christopher P et. al.
Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy.
score: 1.3334875, Antimicrobial agents and chemotherapy, 2002, Nare, Bakela et. al.
A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent simulant
score: 1.3334702, Bioorganic & Medicinal Chemistry Letters, 2012, Wu, Zhisheng et. al.
20-Amino and 20,21-aziridinyl pregnene steroids: Development of potent inhibitors of 17α-hydroxylase/C17,20-lyase (P450 17)
score: 1.3334111, Bioorganic & Medicinal Chemistry, 1996, Njar, Vincent C.O.; Hector, Markus; Hartmann, Rolf W.
Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.
score: 1.3333263, Antimicrobial agents and chemotherapy, 2005, Nitanda, Takao et. al.
Design, synthesis and biological evaluation of 10-CF 3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway
score: 1.3333054, Bioorganic & Medicinal Chemistry, 2003, Desharnais, Joel et. al.
Rigid 5′-6-locked phenanthroline-derived nucleosides chelated to ruthenium and europium ions
score: 1.3332336, Bioorganic & Medicinal Chemistry Letters, 2013, Gislason, Kristmann; Sigurdsson, Snorri Th.
Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines
score: 1.3332051, Bioorganic & Medicinal Chemistry, 2004, Sadashiva, M.P.; Mallesha, H.; Hitesh, N.A.; Rangappa, K.S.
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. † † Part 2. See ref 1. A potential 5-HT transporter imaging agent, 3-(3-[ 18F]fluoropropyl)-6-nitroquipazine
score: 1.3330617, Bioorganic & Medicinal Chemistry, 2003, Lee, Byoung Se et. al.
1. Endothelin antagonists: Search for surrogates of methylendioxyphenyl by means of a kohonen neural network
score: 1.3330614, Bioorganic & Medicinal Chemistry Letters, 1998, Anzali, Soheila et. al.
Quantitative structure–activity relationships for small non-peptide antagonists of CXCR2: Indirect 3D approach using the frontal polygon method
score: 1.3329946, Bioorganic & Medicinal Chemistry, 2006, Khlebnikov, Andrei I.; Schepetkin, Igor A.; Quinn, Mark T.
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
score: 1.3328756, Bioorganic & Medicinal Chemistry, 2012, Wang, Jiangbo et. al.
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
score: 1.3328756, Bioorganic & Medicinal Chemistry, 2012, Wang, Jiangbo et. al.
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
score: 1.3328756, Bioorganic & Medicinal Chemistry, 2012, Wang, Jiangbo et. al.
Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity
score: 1.3328546, Bioorganic & Medicinal Chemistry, 2005, Urban, Milan et. al.
Ultrashort Peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B.
score: 1.3327682, Antimicrobial agents and chemotherapy, 2012, Arnusch, Christopher J et. al.
Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide
score: 1.3327587, Bioorganic & Medicinal Chemistry, 2006, Walker, Joel R. et. al.
Synthesis and preliminary biological evaluation of O 6-[4-(2-[ 18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O 6-alkylguanine-DNA alkyltransferase in cancer chemotherapy
score: 1.3326881, Bioorganic & Medicinal Chemistry, 2005, Wang, Ji-Quan et. al.
Discovery of the butenyl-spinosyn insecticides: Novel macrolides from the new bacterial strain Saccharopolyspora pogona
score: 1.3326622, Bioorganic & Medicinal Chemistry, 2009, Lewer, Paul et. al.
Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents
score: 1.3326571, European Journal of Medicinal Chemistry, 2012, Rashid, Mohd; Husain, Asif; Mishra, Ravinesh
Quinupristin-dalfopristin resistance in Streptococcus pneumoniae: novel L22 ribosomal protein mutation in two clinical isolates from the SENTRY antimicrobial surveillance program.
score: 1.3326026, Antimicrobial agents and chemotherapy, 2003, Jones, Ronald N; Farrell, David J; Morrissey, Ian
Role of a mutation at position 167 of CTX-M-19 in ceftazidime hydrolysis.
score: 1.3325498, Antimicrobial agents and chemotherapy, 2004, Kimura, Soichiro et. al.
Diaryloxy methano phenanthrenes: a new class of antituberculosis agents
score: 1.332539, Bioorganic & Medicinal Chemistry, 2004, Panda, Gautam et. al.
Theoretical calculation of the binding free energies for pyruvate dehydrogenase E1 binding with ligands
score: 1.332504, Bioorganic & Medicinal Chemistry Letters, 2007, Xiong, Ying; Li, Yongjian; He, Hongwu; Zhan, Chang-Guo
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry
score: 1.3323794, Bioorganic & Medicinal Chemistry, 2006, Perreira, Melissa et. al.
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity
score: 1.3323321, Bioorganic & Medicinal Chemistry, 2013, Nag, S. et. al.
Design of mechanism-based carboxypeptidase A inactivators on the basis of the X-ray crystal structure and catalytic reaction pathway [1]
score: 1.3323289, Bioorganic & Medicinal Chemistry, 1998, Lee, Kyung Joo; Kim, Dong H.
Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
score: 1.3321675, Bioorganic & Medicinal Chemistry Letters, 2012, Morris, Kelly M. et. al.
Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
score: 1.3321675, Bioorganic & Medicinal Chemistry Letters, 2012, Morris, Kelly M. et. al.
Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
score: 1.3321675, Bioorganic & Medicinal Chemistry Letters, 2012, Morris, Kelly M. et. al.
Prediction of lipophilicity of polyacenes using quantitative structure–Activity relationships
score: 1.3319832, Bioorganic & Medicinal Chemistry, 2002, Khadikar, Padmakar V.; Agrawal, Vijay K.; Karmarkar, Sneha
Synthesis and biological evaluation of bifendate–chalcone hybrids as a new class of potential P-glycoprotein inhibitors
score: 1.3318878, Bioorganic & Medicinal Chemistry, 2012, Gu, Xiaoke et. al.
Design, synthesis, and biological evaluation of folic acid targeted tetraphenylporphyrin as novel photosensitizers for selective photodynamic therapy
score: 1.3317902, Bioorganic & Medicinal Chemistry, 2005, Schneider, Raphaël et. al.
New dimeric cyclodiphosph(V)azane complexes of Cr(III), Co(II), Ni(II), Cu(II), and Zn(II): Preparation, characterization and biological activity studies
score: 1.3317753, European Journal of Medicinal Chemistry, 2010, Alaghaz, Abdel-Nasser M.A.; Ammar, Reda A.
Derivatives of Plant Phenolic Compound Affect the Type III Secretion System of Pseudomonas aeruginosa via a GacS-GacA Two-Component Signal Transduction System.
score: 1.331753, Antimicrobial agents and chemotherapy, 2012, Yamazaki, Akihiro et. al.
Dendritic chain reaction: Responsive release of hydrogen peroxide upon generation and enzymatic oxidation of methanol
score: 1.3315852, Bioorganic & Medicinal Chemistry, 2010, Avital-Shmilovici, Michal; Shabat, Doron
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
score: 1.3314803, Antimicrobial agents and chemotherapy, 2012, Lam, Angela M et. al.
Positional linker effects in haptens for cocaine immunopharmacotherapy
score: 1.3313806, Bioorganic & Medicinal Chemistry Letters, 2007, Ino, Akira; Dickerson, Tobin J.; Janda, Kim D.
An efficient one-pot synthesis of octahydroquinazolinone derivatives using catalytic amount of H 2SO 4 in water
score: 1.3313634, Bioorganic & Medicinal Chemistry Letters, 2006, Hassani, Zahra; Islami, Mohammad Reza; Kalantari, Maryam
Antitrypanosomal activities of tryptanthrins.
score: 1.3313276, Antimicrobial agents and chemotherapy, 2002, Scovill, John et. al.
Mapping the subunit interface of ribonucleotide reductase (RNR) using photo cross-linking
score: 1.3313225, Bioorganic & Medicinal Chemistry Letters, 2008, Hassan, A. Quamrul; Stubbe, JoAnne
Characteristic resistance mechanism of Mycobacterium tuberculosis to DC-159a, a new respiratory quinolone.
score: 1.3312968, Antimicrobial agents and chemotherapy, 2011, Sekiguchi, Jun-ichiro et. al.
Glycosyl bis-porphyrin conjugates: Synthesis and potential application in PDT
score: 1.3311858, Bioorganic & Medicinal Chemistry, 2006, Sol, V. et. al.
Folacin C 60 derivative exerts a protective activity against oxidative stress-induced apoptosis in rat pheochromocytoma cells
score: 1.3310161, Bioorganic & Medicinal Chemistry Letters, 2010, Hu, Zhen; Guan, Wenchao; Wang, Wei; Zhu, Zhou; Wang, Yanhong
In Silico Binding Free Energy Predictability with π-π interaction energy-augmented scoring function: Benzimidazole Raf Inhibitors as a Case Study
score: 1.3309581, Bioorganic & Medicinal Chemistry Letters, 2012, Chung, Jae Yoon; Cho, Seung Joo; Cho, Art E.; Hah, Jung-Mi
Support for small molecule inhibition of aquaporin 4
score: 1.3308377, Bioorganic & Medicinal Chemistry, 2009, Huber, Vincent J.
The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents
score: 1.3307787, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Yan et. al.
Formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine under anaerobic conditions by reductively activated nitro 5-deazaflavin derivatives
score: 1.3307457, Bioorganic & Medicinal Chemistry Letters, 1999, Mikata, Yuji et. al.
4-Anilinoquinazolines with Lavendustin A subunit as inhibitors of epidermal growth factor receptor tyrosine kinase: syntheses, chemical and pharmacological properties
score: 1.330697, European Journal of Medicinal Chemistry, 2004, Albuschat, Rica et. al.
Docking and 3D-QSAR studies of influenza neuraminidase inhibitors using three-dimensional holographic vector of atomic interaction field analysis
score: 1.3304942, European Journal of Medicinal Chemistry, 2010, Sun, Jiaying; Cai, Shaoxi; Yan, Ning; Mei, Hu
New potent and selective A 1 adenosine receptor agonists
score: 1.3302858, Bioorganic & Medicinal Chemistry, 2004, Hutchinson, Sally A. et. al.
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2 H-1,4-benzodiazepin-2-one (TBO) derivatives. truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1- jk][1,4]benzodiazepin-2(1 H)-ones (TIBO) analogues
score: 1.3301963, Bioorganic & Medicinal Chemistry, 1999, Breslin, Henry J. et. al.
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe
score: 1.3300047, Bioorganic & Medicinal Chemistry Letters, 2012, Delpire, Eric et. al.
Iridium-catalyzed oxidative lactonization and intramolecular Tishchenko reaction of δ-ketoaldehydes for the synthesis of isocoumarins and 3,4-dihydroisocoumarins
score: 1.329946, Bioorganic & Medicinal Chemistry Letters, 2005, Suzuki, Takeyuki et. al.
Identification of a UDP-Gal: GlcNAc-R galactosyltransferase activity in Escherichia coli VW187
score: 1.3299219, Bioorganic & Medicinal Chemistry Letters, 2005, Montoya-Peleaz, Pedro J. et. al.
Non-antibiotic antibacterial activity of dodecyl gallate
score: 1.3298693, Bioorganic & Medicinal Chemistry, 2003, Kubo, Isao et. al.
Phomalairdenone: A new host-selective phytotoxin from a virulent type of the blackleg fungus Phoma lingam
score: 1.3296191, Bioorganic & Medicinal Chemistry Letters, 1999, Pedras, M.Soledade C. et. al.
Ceftaroline versus ceftriaxone in a highly penicillin-resistant pneumococcal pneumonia rabbit model using simulated human dosing.
score: 1.3295971, Antimicrobial agents and chemotherapy, 2011, Croisier-Bertin, Delphine et. al.
Higher order iminodiacetic acid libraries for probing protein-protein interactions
score: 1.3295283, Bioorganic & Medicinal Chemistry Letters, 1998, Boger, Dale L. et. al.
Chemical screening of an inhibitor for gibberellin receptors based on a yeast two-hybrid system
score: 1.3294281, Bioorganic & Medicinal Chemistry Letters, 2013, Yoon, Jung-Min et. al.
New photoantimicrobial films composed of porphyrinated lipophilic cellulose esters
score: 1.329324, Bioorganic & Medicinal Chemistry Letters, 2006, Krouit, Mohammed et. al.
Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues
score: 1.3288675, Bioorganic & Medicinal Chemistry, 2003, Valgeirsson, Jon et. al.
Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2
score: 1.3288649, Bioorganic & Medicinal Chemistry, 2013, Tsukuda, Senko et. al.
In vitro antiviral interaction of lopinavir with other protease inhibitors.
score: 1.3286868, Antimicrobial agents and chemotherapy, 2002, Molla, Akhteruzzaman et. al.
The β-glucuronyl-based prodrug strategy allows for its application on β-glucuronyl-platinum conjugates
score: 1.3286, Bioorganic & Medicinal Chemistry Letters, 2004, Tromp, Reynier A et. al.
In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans.
score: 1.328558, Antimicrobial agents and chemotherapy, 2006, Hasenoehrl, Andreja et. al.
Synthesis of novel morphiceptin analogues modified in position 3 and their binding to μ-opioid receptors in experimental mammary adenocarcinoma
score: 1.328414, Bioorganic & Medicinal Chemistry, 2003, Janecka, A; Fichna, J; Wiercioch, R; Mirowski, M
Synthesis of derivatives of (1 S,2 R)-1-phenyl-2-[( S)-1-aminopropyl] -N,N-diethylcyclopropanecarboxamide (PPDC) modified at the 1-aromatic moiety as novel NMDA receptor antagonists: the aromatic group is essential for the activity
score: 1.3282482, Bioorganic & Medicinal Chemistry, 2002, Kazuta, Yuji et. al.
Activities of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells.
score: 1.3282113, Antimicrobial agents and chemotherapy, 2011, Topalis, D; Lebeau, I; Krecmerová, M; Andrei, G; Snoeck, R
Contrasting fates for 6-α-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS)
score: 1.328193, Bioorganic & Medicinal Chemistry Letters, 2001, Hamilton, Christopher S et. al.
2′-deoxy-8-(propyn-1-yl)adenosine-containing oligonucleotides: effects on stability of duplex and quadruplex structures
score: 1.3281827, Bioorganic & Medicinal Chemistry Letters, 2000, Catalanotti, Bruno et. al.
Synthesis and pharmacology of pyrido[2,3- d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists
score: 1.3280749, Bioorganic & Medicinal Chemistry, 2006, Bulicz, Jacek et. al.
An Escherichia coli expression assay and screen for human immunodeficiency virus protease variants with decreased susceptibility to indinavir.
score: 1.3280531, Antimicrobial agents and chemotherapy, 1998, Melnick, L; Yang, S S; Rossi, R; Zepp, C; Heefner, D
Biochemical Characterization of the TEM-107 Extended-Spectrum β-Lactamase in a Klebsiella pneumoniae Isolate from South Korea.
score: 1.3280043, Antimicrobial agents and chemotherapy, 2011, Lee, Kyungwon et. al.
A Laccase-Catalysed One-Pot Synthesis of Aminonaphthoquinones and their Anticancer activity
score: 1.3279622, Bioorganic & Medicinal Chemistry, 2012, Wellington, Kevin W.; Kolesnikova, Natasha I.
Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities
score: 1.3278984, Bioorganic & Medicinal Chemistry Letters, 2012, Chang, Minsun et. al.
Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities
score: 1.3278984, Bioorganic & Medicinal Chemistry Letters, 2012, Chang, Minsun et. al.
Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase
score: 1.3278247, Bioorganic & Medicinal Chemistry, 2005, Xu, Ya-ming; Johnson, Randall K.; Hecht, Sidney M.
Synthesis and antimicrobial activity of pyranobenzoquinones related to the pyranonaphthoquinone antibiotics
score: 1.3278106, European Journal of Medicinal Chemistry, 2006, Lagorio, S.H.; Bianchi, D.A.; Sutich, E.G.; Kaufman, T.S.
Synthesis and preliminary biochemical assessment of ethyl-terminated perfluoroalkylamine oxide surfactants
score: 1.3277896, Bioorganic & Medicinal Chemistry Letters, 2002, Chaudier, Yann et. al.
Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein Kinase D
score: 1.3277133, Bioorganic & Medicinal Chemistry Letters, 1999, Irie, Kazuhiro et. al.
Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein Kinase D
score: 1.3277133, Bioorganic & Medicinal Chemistry Letters, 1999, Irie, Kazuhiro et. al.
Synthesis and structure–activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity
score: 1.3276618, Bioorganic & Medicinal Chemistry, 2006, Neighbors, Jeffrey D. et. al.
Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist
score: 1.3276268, Bioorganic & Medicinal Chemistry, 1994, Bondinell, William E. et. al.
Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles
score: 1.3275344, Bioorganic & Medicinal Chemistry Letters, 2012, Lal, Kashmiri; Kumar, Ashwani; Pavan, M.S.; Kaushik, C.P.
Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles
score: 1.3275344, Bioorganic & Medicinal Chemistry Letters, 2012, Lal, Kashmiri; Kumar, Ashwani; Pavan, M.S.; Kaushik, C.P.
Unified drug–target interaction thermodynamic Markov model using stochastic entropies to predict multiple drugs side effects
score: 1.3275071, European Journal of Medicinal Chemistry, 2005, Cruz-Monteagudo, Maykel; González-Díaz, Humberto
Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery
score: 1.3271648, Bioorganic & Medicinal Chemistry Letters, 2010, Thomas, Thommey P. et. al.
An expedient synthesis of N α-protected- l-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease
score: 1.3271075, Bioorganic & Medicinal Chemistry Letters, 2002, Rajesh, S. et. al.
Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats.
score: 1.3270422, Antimicrobial agents and chemotherapy, 2002, Song, Heng et. al.
Iminosugars: potential inhibitors of liver glycogen phosphorylase
score: 1.3270361, Bioorganic & Medicinal Chemistry, 2001, Jakobsen, Palle et. al.
2′- O,4′- C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug
score: 1.3269989, Bioorganic & Medicinal Chemistry Letters, 2002, Morita, Koji et. al.
SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei").
score: 1.3269014, Antimicrobial agents and chemotherapy, 2000, Al-Abdely, H M et. al.
Synthesis and evaluation of the permeability transition inhibitory characteristics of paramagnetic and diamagnetic amiodarone derivatives
score: 1.3268102, Bioorganic & Medicinal Chemistry, 2005, Kálai, Tamás et. al.
Synthesis and antimalarial activities of novel 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes
score: 1.3267703, Bioorganic & Medicinal Chemistry, 2006, Žmitek, Katja et. al.
Development of New Carbon-11 Labelled Radiotracers for Imaging GABAA- and GABAB-Benzodiazepine Receptors
score: 1.326665, Bioorganic & Medicinal Chemistry, 2012, Moran, Matthew D. et. al.
Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA
score: 1.3266512, Bioorganic & Medicinal Chemistry, 2009, Taniguchi, Yosuke et. al.
Synthesis and biological properties of a new series of anti-MRSA β-lactams; 2-(thiazol-2-ylthio)carbapenems
score: 1.3266298, Bioorganic & Medicinal Chemistry, 1997, Shinagawa, Hisatoshi et. al.
Synthesis and studies on some new fluorine containing triazolothiadiazines as possible antibacterial, antifungal and anticancer agents
score: 1.3266255, European Journal of Medicinal Chemistry, 2006, Shivarama Holla, B. et. al.
N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases
score: 1.3265085, Bioorganic & Medicinal Chemistry Letters, 2012, Santana, Ana Bela et. al.
Preparation of chitosan–copper complexes and their antitumor activity
score: 1.3264656, Bioorganic & Medicinal Chemistry Letters, 2006, Zheng, Yong et. al.
Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents
score: 1.3264244, European Journal of Medicinal Chemistry, 2012, Zhang, Feng et. al.
Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT 1A, 5-HT 2A, and D 2 receptor activity
score: 1.3263123, Bioorganic & Medicinal Chemistry, 2005, Paluchowska, Maria H. et. al.
N-Demethylation of nocathiacin I via photo-oxidation
score: 1.3262546, Bioorganic & Medicinal Chemistry Letters, 2008, Li, Wenying et. al.
Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m
score: 1.3261125, Bioorganic & Medicinal Chemistry Letters, 2010, de Barros, André Luís Branco et. al.
Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
score: 1.3260501, European Journal of Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
The trifluoromethyl transformation synthesis, crystal structure and insecticidal activities of novel 2-pyrrolecarboxamide and 2-pyrrolecarboxlate
score: 1.3258562, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Yongqiang et. al.
The trifluoromethyl transformation synthesis, crystal structure and insecticidal activities of novel 2-pyrrolecarboxamide and 2-pyrrolecarboxlate
score: 1.3258562, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Yongqiang et. al.
Synthesis, further biological evaluation and pharmacodynamics of newly discovered inhibitors of TNF-α production
score: 1.3257706, Bioorganic & Medicinal Chemistry, 2003, Matsui, Toshiaki et. al.
Synthesis of characteristic lipopeptides of the human N- Ras protein and their evaluation as possible inhibitors of protein farnesyl transferase
score: 1.3255913, Bioorganic & Medicinal Chemistry, 1997, Stöber, Paul et. al.
NBS–DMSO as a nonaqueous nonbasic oxidation reagent for the synthesis of oligonucleotides
score: 1.3255774, Bioorganic & Medicinal Chemistry Letters, 2003, Uzagare, Matthew C. et. al.
A fluorescein-containing, small-molecule, water-soluble receptor for cytosine free bases
score: 1.3255116, Bioorganic & Medicinal Chemistry, 2010, Jiang, Yu Lin; Patel, Puneet; Klein, Suzane M.
Requirement of the glycosyl parts in platycodin D to stimulate pancreatic exocrine secretion
score: 1.3254863, Bioorganic & Medicinal Chemistry Letters, 1998, Ida, Yoshiteru et. al.
In vitro activity of ceftobiprole against aerobic and anaerobic strains isolated from diabetic foot infections.
score: 1.3254726, Antimicrobial agents and chemotherapy, 2006, Goldstein, Ellie J C et. al.
3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents
score: 1.3254579, European Journal of Medicinal Chemistry, 2012, Plsikova, Jana et. al.
3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents
score: 1.3254579, European Journal of Medicinal Chemistry, 2012, Plsikova, Jana et. al.
Synthesis of carbamate-linked lipids for gene delivery
score: 1.325291, Bioorganic & Medicinal Chemistry Letters, 2005, Liu, Dongliang et. al.
Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae
score: 1.32522, Bioorganic & Medicinal Chemistry, 2006, Aguirre, María C. et. al.
A hierarchical method for molecular docking using cloud computing
score: 1.3251605, Bioorganic & Medicinal Chemistry Letters, 2012, Kang, Ling; Guo, Quan; Wang, Xicheng
A hierarchical method for molecular docking using cloud computing
score: 1.3251605, Bioorganic & Medicinal Chemistry Letters, 2012, Kang, Ling; Guo, Quan; Wang, Xicheng
In vitro evaluation of novel compounds against selected resistant Pseudomonas aeruginosa isolates.
score: 1.3251253, Antimicrobial agents and chemotherapy, 2012, Housman, Seth T; Sutherland, Christina; Nicolau, David P
ssDNA aptamers that selectively bind oxytetracycline
score: 1.3248955, Bioorganic & Medicinal Chemistry, 2008, Niazi, Javed H.; Lee, Su Jin; Kim, Yeon Seok; Gu, Man Bock
Synthesis and cytotoxic activity of N, N-bis-{3-[ N-(4-chlorobenzo[ g]-phthalazin-1-yl)]aminopropyl}- N-methylamine: a new potential DNA bisintercalator
score: 1.3244595, Bioorganic & Medicinal Chemistry, 2003, Rodrı́guez-Ciria, Marinela et. al.
Synthesis and biological evaluation of new 4-arylpiperidines and 4-aryl-4-piperidinols: dual Na + and Ca 2+ channel blockers with reduced affinity for dopamine D 2 receptors
score: 1.3244546, Bioorganic & Medicinal Chemistry, 2002, Annoura, Hirokazu et. al.
Computational modeling study of functional microdomains in cannabinoid receptor type 1
score: 1.3243371, Bioorganic & Medicinal Chemistry, 2008, Gonzalez, Angel et. al.
Antagonists of myo-inositol 3,4,5,6-tetrakisphosphate allow repeated epithelial chloride secretion
score: 1.3241517, Bioorganic & Medicinal Chemistry, 2003, Rudolf, Marco T et. al.
Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effects
score: 1.3240528, Bioorganic & Medicinal Chemistry Letters, 2012, Woo, Kyeong Wan et. al.
Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives
score: 1.3239713, Bioorganic & Medicinal Chemistry, 2004, Parrish, Jay P. et. al.
Difluoropalmitic acids as potential inhibitors of the biosynthesis of the sex pheromone of the Egyptian armyworm Spodoptera littoralis—IV
score: 1.3239248, Bioorganic & Medicinal Chemistry, 1996, Bosch, M.P. et. al.
Synthesis of galactosyl compounds for targeted gene delivery
score: 1.3238351, Bioorganic & Medicinal Chemistry, 2001, Ren, Tan; Zhang, Guisheng; Liu, Dexi
Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance.
score: 1.3237535, Antimicrobial agents and chemotherapy, 2005, Wetzstein, H-G
Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds
score: 1.3235744, Bioorganic & Medicinal Chemistry, 1998, Huang, Li-Jiau et. al.
Synthesis and Cytotoxicity of Novel Ursolic Acid Derivatives Containing an Acyl Piperazine Moiety
score: 1.3235172, European Journal of Medicinal Chemistry, 2012, Liu, Ming-Chuan et. al.
Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging
score: 1.323404, Bioorganic & Medicinal Chemistry, 2009, Nakata, Eiji et. al.
Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.
score: 1.3232579, Antimicrobial agents and chemotherapy, 1999, Poirel, L et. al.
Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell-mediated human immunodeficiency virus transfer.
score: 1.3232327, Antimicrobial agents and chemotherapy, 2008, Teleshova, Natalia et. al.
A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors
score: 1.3232046, European Journal of Medicinal Chemistry, 2003, Michaux, Catherine et. al.
An anionic inositol phosphate glycan pseudotetrasaccharide exhibits high insulin-mimetic activity in rat adipocytes
score: 1.3231994, Bioorganic & Medicinal Chemistry, 2005, Chakraborty, Nilanjana; d’Alarcao, Marc
Reaction of guanosine with glucose under oxidative conditions
score: 1.3231373, Bioorganic & Medicinal Chemistry Letters, 1998, Seidel, Wolfgang; Pischetsrieder, Monika
Electron-conformational study for the structure–hallucinogenic activity relationships of phenylalkylamines
score: 1.3231259, Bioorganic & Medicinal Chemistry, 2003, Altun, Ahmet et. al.
In vitro evaluation of a new treatment for urinary tract infections caused by nitrate-reducing bacteria.
score: 1.3230954, Antimicrobial agents and chemotherapy, 2003, Carlsson, S et. al.
Discovery of 6-[4-(6-nitroxyhexanoyl)piperazin-1-yl)]-9H-purine, as pharmacological post-conditioning agent
score: 1.3230279, Bioorganic & Medicinal Chemistry, 2012, Koufaki, Maria et. al.
Synthesis of 13C- and 14C-labeled dinucleotide mRNA cap analogues for structural and biochemical studies
score: 1.3227482, Bioorganic & Medicinal Chemistry Letters, 2012, Piecyk, Karolina et. al.
Synthesis of 13C- and 14C-labeled dinucleotide mRNA cap analogues for structural and biochemical studies
score: 1.3227482, Bioorganic & Medicinal Chemistry Letters, 2012, Piecyk, Karolina et. al.
Synthesis and biological activities of 2′-deoxy-2′-fluoro-4′-thioarabinofuranosylpyrimidine and -purine nucleosides
score: 1.3227139, Bioorganic & Medicinal Chemistry, 2000, Yoshimura, Yuichi et. al.
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
score: 1.3226451, Bioorganic & Medicinal Chemistry, 2012, Kniess, Torsten et. al.
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
score: 1.3226451, Bioorganic & Medicinal Chemistry, 2012, Kniess, Torsten et. al.
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
score: 1.3226451, Bioorganic & Medicinal Chemistry, 2012, Kniess, Torsten et. al.
Simplified bicyclic pyridinol analogues protect mitochondrial function
score: 1.3225622, Bioorganic & Medicinal Chemistry, 2012, Cai, Xiaoqing et. al.
The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations
score: 1.3225187, Bioorganic & Medicinal Chemistry, 1996, Dörner, Barbara et. al.
Modeling the antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides using different chemometrics methods
score: 1.3224668, European Journal of Medicinal Chemistry, 2010, Garkani-Nejad, Zahra; Ahmadi-Roudi, Behzad
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins
score: 1.3224607, Bioorganic & Medicinal Chemistry Letters, 2008, Brustad, Eric et. al.
Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae.
score: 1.3224247, Antimicrobial agents and chemotherapy, 2000, Lunde, C S; Kubo, I
Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis.
score: 1.3223905, Antimicrobial agents and chemotherapy, 2010, Harmon, Dana E et. al.
Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37.
score: 1.3222482, Antimicrobial agents and chemotherapy, 2009, Epand, Raquel F et. al.
A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans
score: 1.3221684, Bioorganic & Medicinal Chemistry, 2004, Kim, In Jong et. al.
Synthesis and DNA binding properties of 1-(3-aminopropyl)-imidazole-containing triamide f-Im∗PyIm: A novel diamino polyamide designed to target 5′-ACGCGT-3′
score: 1.3221302, Bioorganic & Medicinal Chemistry Letters, 2012, Satam, Vijay et. al.
Synthesis, characterization and in vitro antitumour activity of a series of novel platinum(II) complexes bearing Schiff base ligands
score: 1.3220723, European Journal of Medicinal Chemistry, 2012, Proetto, Maria et. al.
YM-254890 analogues, novel cyclic depsipeptides with Gα q/11 inhibitory activity from Chromobacterium sp. QS3666
score: 1.3219054, Bioorganic & Medicinal Chemistry, 2004, Taniguchi, Masatoshi et. al.
DNA triplex stabilization by a δ-carboline derivative tethered to third strand oligonucleotides
score: 1.3218774, Bioorganic & Medicinal Chemistry Letters, 2006, Todorović, Nina et. al.
Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug
score: 1.3217728, Bioorganic & Medicinal Chemistry, 2004, Sekine, Mitsuo et. al.
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.
score: 1.3217504, Antimicrobial agents and chemotherapy, 2009, Oppegard, Lisa M et. al.
Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging
score: 1.3217481, Bioorganic & Medicinal Chemistry Letters, 2010, Xiao, Li et. al.
Antitumor agents. Part 227: Studies on novel 4′- O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II
score: 1.321621, Bioorganic & Medicinal Chemistry, 2004, Xiao, Zhiyan et. al.
Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays
score: 1.3216008, Bioorganic & Medicinal Chemistry, 2003, Soulère, Laurent et. al.
Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).
score: 1.3215962, Antimicrobial agents and chemotherapy, 2005, Sekiguchi, Jun-ichiro et. al.
XH-14 analogues as adenosine antagonists
score: 1.3215854, Bioorganic & Medicinal Chemistry, 1998, Scammells, Peter J. et. al.
Role of solution conformation and flexibility of short peptide ligands that bind to the p56 lck SH2 domain
score: 1.3215241, Bioorganic & Medicinal Chemistry, 2003, Dekker, Frank J et. al.
Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent
score: 1.3212078, Bioorganic & Medicinal Chemistry, 2004, Lohray, Braj Bhushan et. al.
Synthesis and incorporation of an α-hexofuranosyl thymidine into oligodeoxynucleotides via its two exocyclic OH-groups
score: 1.321061, Bioorganic & Medicinal Chemistry Letters, 2004, Filichev, Vyacheslav V.; Pedersen, Erik B.
Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M 2 receptors
score: 1.3209696, Bioorganic & Medicinal Chemistry, 2000, Martin, Juliette et. al.
Multistep resistance development studies of ceftaroline in gram-positive and -negative bacteria.
score: 1.320779, Antimicrobial agents and chemotherapy, 2011, Clark, Catherine et. al.
Microbial biotransformation as a source of chemical diversity in cane toad steroid toxins
score: 1.3207784, Bioorganic & Medicinal Chemistry Letters, 2009, Hayes, R. Andrew et. al.
Molecular modeling of ( E)-1-alkyl-4(3)-[2-(1 H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase
score: 1.3207488, Bioorganic & Medicinal Chemistry, 1997, Alcalde, Ermitas et. al.
Topoisomerase I inhibition and cytotoxicity of 5-Bromo- and 5-Phenylterbenzimidazoles
score: 1.3206634, Bioorganic & Medicinal Chemistry, 2000, Rangarajan, Meera et. al.
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
score: 1.3204647, Nature Chemical Biology, 2011, White, Tina R. et. al.
Molecular design, chemical synthesis, and evaluation of cytosine–carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA
score: 1.3203475, Bioorganic & Medicinal Chemistry Letters, 2005, Idutsu, Yusuke et. al.
Antihelminthic activity of some newly synthesized 5(6)-(un)substituted-1 H-benzimidazol-2-ylthioacetylpiperazine derivatives
score: 1.3203446, European Journal of Medicinal Chemistry, 2006, Mavrova, Anelia Ts. et. al.
Design, Synthesis and Biological Evaluation of New 5,5-Diarylhydantoin Derivatives as Selective Cyclooxygenase-2 Inhibitors
score: 1.3203317, Scientia Pharmaceutica, 2011, Zarghi, Afshin et. al.
Structural requirements of dictyopyrones isolated from Dictyostelium spp. in the regulation of Dictyostelium development and in anti-leukemic activity
score: 1.3202137, Bioorganic & Medicinal Chemistry, 2004, Kikuchi, Haruhisa et. al.
Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.
score: 1.3202084, Antimicrobial agents and chemotherapy, 2004, Ewart, Gary D et. al.
Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates
score: 1.3201656, Bioorganic & Medicinal Chemistry, 2006, Liang, Fu-Sen et. al.
New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris
score: 1.3201068, Bioorganic & Medicinal Chemistry, 2001, Wu, Tian-Shung et. al.
Effect of O-glycosilation on the antioxidant activity and free radical reactions of a plant flavonoid, chrysoeriol
score: 1.320069, Bioorganic & Medicinal Chemistry, 2003, Mishra, Beena et. al.
DNA sequence recognition by an imidazole-containing isopropyl-substituted thiazole polyamide (thiazotropsin B)
score: 1.3200153, Bioorganic & Medicinal Chemistry Letters, 2006, Hampshire, Andrew J. et. al.
Plant sterols as selective DNA polymerase β lyase inhibitors and potentiators of bleomycin cytotoxicity
score: 1.319947, Bioorganic & Medicinal Chemistry, 2004, Li, Shi-Sheng et. al.
RGD mounted on an L-proline scaffold
score: 1.3199316, Bioorganic & Medicinal Chemistry Letters, 2005, Enholm, Eric; Bharadwaj, Ashwin
Photoinduced DNA cleavage by anthracene based hydroxamic acids
score: 1.3197022, Bioorganic & Medicinal Chemistry Letters, 2012, Chowdhury, Nilanjana; Dasgupta, Swagata; Pradeep Singh, N.D.
In vitro activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia species.
score: 1.3196489, Antimicrobial agents and chemotherapy, 2012, Cynamon, Michael et. al.
Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α,25-dihydroxyvitamin D 3: cis-perhydrindane CE-ring analogues
score: 1.3195535, Bioorganic & Medicinal Chemistry Letters, 2004, Demin, Samuël et. al.
Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites.
score: 1.3194243, Antimicrobial agents and chemotherapy, 2007, Lüscher, Alexandra et. al.
Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[ 11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2′,2′-diphenylpropionoxymethyl)pyridinium
score: 1.3193994, Bioorganic & Medicinal Chemistry Letters, 2005, Wang, Ji-Quan et. al.
Synthesis and electrochemical studies of a new iron tetra-catecholamide complex
score: 1.3193909, Bioorganic & Medicinal Chemistry Letters, 1999, Cheraïti, N. et. al.
Identification of Selective Inhibitors of Indoleamine 2,3-Dioxygenase 2
score: 1.3193886, Bioorganic & Medicinal Chemistry Letters, 2012, Bakmiwewa, Supun M. et. al.
The synthesis and screening of 1,4,5,8-naphthalenetetracarboxylic diimide–peptide conjugates with antibacterial activity
score: 1.3192784, Bioorganic & Medicinal Chemistry, 2001, Miller, Chandra T et. al.
Prediction of the evolution of ceftazidime resistance in extended-spectrum beta-lactamase CTX-M-9.
score: 1.3192546, Antimicrobial agents and chemotherapy, 2006, Delmas, J; Robin, F; Carvalho, F; Mongaret, C; Bonnet, R
Alternative pathway of metronidazole activation in Trichomonas vaginalis hydrogenosomes.
score: 1.3192291, Antimicrobial agents and chemotherapy, 2005, Hrdý, Ivan et. al.
Iridoid glucosides and a C13-norisoprenoid from Lamiophlomis rotata and their effects on NF-κB activation
score: 1.3191894, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Feng et. al.
Iridoid glucosides and a C13-norisoprenoid from Lamiophlomis rotata and their effects on NF-κB activation
score: 1.3191894, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Feng et. al.
Iridoid glucosides and a C13-norisoprenoid from Lamiophlomis rotata and their effects on NF-κB activation
score: 1.3191894, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Feng et. al.
Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus.
score: 1.3191295, Antimicrobial agents and chemotherapy, 1999, Mosher, R H et. al.
Synthesis and structure–activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities
score: 1.319081, Bioorganic & Medicinal Chemistry, 2006, Moon, Myoung Ju et. al.
γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement
score: 1.319052, Bioorganic & Medicinal Chemistry Letters, 2012, Henry, Luc et. al.
Myrosinase-generated isothiocyanate from glucosinolates: Isolation, characterization and in vitro antiproliferative studies
score: 1.3190446, Bioorganic & Medicinal Chemistry, 1997, Leoni, O. et. al.
Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands
score: 1.318937, Bioorganic & Medicinal Chemistry, 2003, Menegatti, Ricardo et. al.
Synthesis and antimalarial activity of a new series of trioxaquines
score: 1.3189049, Bioorganic & Medicinal Chemistry, 2004, Singh, Chandan; Malik, Heetika; Puri, Sunil K
Identification of small molecule inhibitors against SecA of Candidatus Liberibacter asiaticus by structure based design
score: 1.3188522, European Journal of Medicinal Chemistry, 2012, Akula, Nagaraju; Trivedi, Pankaj; Han, Frank Q.; Wang, Nian
Docking experiments in the flexible non-nucleoside inhibitor binding pocket of HIV-1 reverse transcriptase
score: 1.3188004, Bioorganic & Medicinal Chemistry, 1999, Titmuss, Stephen J; Keller, Paul A; Griffith, Renate
Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition
score: 1.3187616, Bioorganic & Medicinal Chemistry, 2006, Parekh, Harendra S. et. al.
Synthesis of ethylenediamine linked β-cyclodextrin dimer and its analytical application for tranilast determination by spectrofluorimetry
score: 1.3187593, Bioorganic & Medicinal Chemistry, 2006, Tang, Bo; Liang, Hui-ling; Tong, Li-li; Li, Ping
Enantiomeric N-methyl-4-piperidyl benzilates as muscarinic receptor ligands: Radioligand binding studies and docking studies to models of the three muscarinic receptors M1, M2 and M3
score: 1.3187389, Bioorganic & Medicinal Chemistry, 2006, Selent, Jana et. al.
Antifungal activities and cytotoxicity studies of six new azasordarins.
score: 1.3187184, Antimicrobial agents and chemotherapy, 2001, Herreros, E et. al.
Synthesis and cytotoxic activity of novel quinazolino-β-carboline-5-one derivatives
score: 1.3187121, Bioorganic & Medicinal Chemistry, 2004, Baruah, Bipul et. al.
Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling
score: 1.318698, Bioorganic & Medicinal Chemistry, 2006, Gal, Julien Le et. al.
Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus.
score: 1.3186704, Antimicrobial agents and chemotherapy, 2006, Wang, Wen; White, Richard; Yuan, Zhengyu
Synthesis and characterization of novel azo-morphine derivatives for possible use in abused drugs analysis
score: 1.3186224, European Journal of Medicinal Chemistry, 2008, Alnajjar, Ahmed O.; El-Zaria, Mohamed E.
Effects of 4,4-Dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-Dimethyl-5,8-dihydroxytetralone derivatives on tumor cell respiration
score: 1.3185776, Bioorganic & Medicinal Chemistry, 2002, Araya-Maturana, Ramiro et. al.
Triplex forming ability of oligonucleotides containing 2′- O-methyl-2-thiouridine or 2-thiothymidine
score: 1.318508, Bioorganic & Medicinal Chemistry Letters, 2006, Okamoto, Itaru; Seio, Kohji; Sekine, Mitsuo
Carbonic anhydrase inhibitors: Sulfonamides as antitumor agents?
score: 1.318506, Bioorganic & Medicinal Chemistry, 2001, Supuran, Claudiu T et. al.
Optimization of xanthones for antimalarial activity: the 3,6-bis-omega-diethylaminoalkoxyxanthone series.
score: 1.318498, Antimicrobial agents and chemotherapy, 2002, Kelly, Jane Xu et. al.
Comparative binding study of steroidal adenine with flavin and uracil derivatives
score: 1.3184688, Bioorganic & Medicinal Chemistry Letters, 2005, Rai, Roopali; Pandey, Pramod S.
Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay
score: 1.318465, Bioorganic & Medicinal Chemistry, 2004, Zhang, Han-Zhong et. al.
β-Lapachone analogs with enhanced antiproliferative activity
score: 1.3184379, European Journal of Medicinal Chemistry, 2012, Ríos-Luci, Carla et. al.
β-Lapachone analogs with enhanced antiproliferative activity
score: 1.3184379, European Journal of Medicinal Chemistry, 2012, Ríos-Luci, Carla et. al.
β-Lapachone analogs with enhanced antiproliferative activity
score: 1.3184379, European Journal of Medicinal Chemistry, 2012, Ríos-Luci, Carla et. al.
Synthesis and characterization of folic acid modified water-soluble chitosan derivatives for folate-receptor-mediated targeting
score: 1.3184186, Bioorganic & Medicinal Chemistry Letters, 2012, Jing, Huihui et. al.
Synthesis and characterization of folic acid modified water-soluble chitosan derivatives for folate-receptor-mediated targeting
score: 1.3184186, Bioorganic & Medicinal Chemistry Letters, 2012, Jing, Huihui et. al.
Synthesis and characterization of folic acid modified water-soluble chitosan derivatives for folate-receptor-mediated targeting
score: 1.3184186, Bioorganic & Medicinal Chemistry Letters, 2012, Jing, Huihui et. al.
Assamicin I and II, Novel Triterpenoid Saponins with Insulin-Like Activity from Aesculus assamica Griff.
score: 1.3183889, Bioorganic & Medicinal Chemistry Letters, 2002, Sakurai, Takashi et. al.
Solid-Phase synthesis of 4-substituted imidazoles using a scaffold approach
score: 1.3183543, Bioorganic & Medicinal Chemistry Letters, 2000, Gelens, E. et. al.
The use of power ultrasound coupled with magnetic separation for the solid phase synthesis of compound libraries
score: 1.3182846, Bioorganic & Medicinal Chemistry Letters, 2000, Perez, J.Manuel; Wilhelm, Eric J.; Sucholeiki, Irving
Malassezin—a novel agonist of the Arylhydrocarbon receptor from the yeast Malassezia furfur
score: 1.3182754, Bioorganic & Medicinal Chemistry, 2001, Wille, Gregor et. al.
Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties
score: 1.3182589, Bioorganic & Medicinal Chemistry, 2003, Marminon, Christelle et. al.
Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents
score: 1.3182213, European Journal of Medicinal Chemistry, 2012, Rashid, Mohd; Husain, Asif; Mishra, Ravinesh
Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effects
score: 1.318105, Bioorganic & Medicinal Chemistry Letters, 2012, Woo, Kyeong Wan et. al.
Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effects
score: 1.318105, Bioorganic & Medicinal Chemistry Letters, 2012, Woo, Kyeong Wan et. al.
Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effects
score: 1.318105, Bioorganic & Medicinal Chemistry Letters, 2012, Woo, Kyeong Wan et. al.
A convergent synthesis of core 2 branched sialylated and sulfated oligosaccharides
score: 1.3180056, Bioorganic & Medicinal Chemistry, 2002, Xia, Jie et. al.
Pharmacophore-based small molecule CXCR4 ligands
score: 1.3179567, Bioorganic & Medicinal Chemistry Letters, 2012, Narumi, Tetsuo et. al.
C-3 halo and 3-methyl substituted 5′-nor-3-deazaaristeromycins: Synthesis and antiviral properties
score: 1.3178568, Bioorganic & Medicinal Chemistry, 2013, Liu, Chong; Chen, Qi; Yang, Minmin; Schneller, Stewart W.
Low level of cross-resistance to amprenavir (141W94) in samples from patients pretreated with other protease inhibitors.
score: 1.3178506, Antimicrobial agents and chemotherapy, 2000, Schmidt, B et. al.
Anti-HIV coumarins from calophyllum seed oil
score: 1.3177695, Bioorganic & Medicinal Chemistry Letters, 1998, Spino, Claude; Dodier, Marco; Sotheeswaran, Subramaniam
Synthesis and characterization of oligonucleotide conjugates bearing electroactive labels
score: 1.3177623, Bioorganic & Medicinal Chemistry Letters, 2013, Moreau, Julie et. al.
Synthesis and characterization of oligonucleotide conjugates bearing electroactive labels
score: 1.3177623, Bioorganic & Medicinal Chemistry Letters, 2013, Moreau, Julie et. al.
Synthesis of 11C-labeled 2-aminoethanol via a nitroaldol reaction using nitro[ 11C]methane
score: 1.3176709, Bioorganic & Medicinal Chemistry Letters, 2009, Kato, Koichi et. al.
Binding to δ and μ opioid receptors by deltorphin I/II analogues modified at the Phe 3 and Asp 4/Glu 4 side chains: a report of 32 new analogues and a QSAR study
score: 1.3176185, Bioorganic & Medicinal Chemistry, 1997, Schullery, Stephen E. et. al.
‘ O-Acyl isopeptide method’ for the efficient preparation of amyloid β peptide 1–42 mutants
score: 1.3175975, Bioorganic & Medicinal Chemistry, 2005, Sohma, Youhei et. al.
OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins.
score: 1.3175853, Antimicrobial agents and chemotherapy, 2011, Poirel, Laurent et. al.
Systems biology and combination therapy in the quest for clinical efficacy.
score: 1.317538, Nature chemical biology, 2006, Fitzgerald, Jonathan B et. al.
A chimeric peptide composed of a dermaseptin derivative and an RNA III-inhibiting peptide prevents graft-associated infections by antibiotic-resistant staphylococci.
score: 1.3174859, Antimicrobial agents and chemotherapy, 2004, Balaban, Naomi et. al.
Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus.
score: 1.317453, Antimicrobial agents and chemotherapy, 2003, Ince, Dilek et. al.
Positional effects of monofluorinated phenylalanines on histone acetyltransferase stability and activity
score: 1.3172208, Bioorganic & Medicinal Chemistry Letters, 2009, Voloshchuk, Natalya et. al.
Synthesis of an antitumor active endoperoxide from 11-keto-β-boswellic acid
score: 1.3170222, European Journal of Medicinal Chemistry, 2010, Csuk, René et. al.
Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dichloro-8-quinolinolato-lanthanides
score: 1.3169185, European Journal of Medicinal Chemistry, 2013, Chen, Zhen-Feng et. al.
Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dichloro-8-quinolinolato-lanthanides
score: 1.3169185, European Journal of Medicinal Chemistry, 2013, Chen, Zhen-Feng et. al.
Insecticidal activity of proteinous venom from tentacle of jellyfish Rhopilema esculentum Kishinouye
score: 1.3168905, Bioorganic & Medicinal Chemistry Letters, 2005, Yu, Huahua et. al.
Synthesis and fluorescence studies of thiazole orange tethered onto oligonucleotide: development of a self-contained DNA biosensor on a fiber optic surface
score: 1.3168848, Bioorganic & Medicinal Chemistry Letters, 2005, Wang, Xiaofeng; Krull, Ulrich J.
Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
score: 1.3168605, Antimicrobial agents and chemotherapy, 2006, Chau, Andrew S et. al.
Rational drug design for anti-cancer chemotherapy: Multi-target QSAR models for the in silico discovery of anti-colorectal cancer agents
score: 1.3167988, Bioorganic & Medicinal Chemistry, 2012, Speck-Planche, Alejandro et. al.
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay.
score: 1.316673, Antimicrobial agents and chemotherapy, 2011, Yang, Chi-Chen et. al.
Studies of interaction of trichloro{η 2- cis- N, N-dimethyl-1-[6-( N′, N′-dimethyl-ammoniummethyl)-cyclohex-3-ene-1-yl]-methylammonium}platinum(II) chloride with DNA: Effects on secondary and tertiary structures of DNA. Cytotoxic assays on human ovarian cancer cell lines, resistant and non-resistant to cisplatin
score: 1.3166083, Bioorganic & Medicinal Chemistry, 2006, Gay, Marina et. al.
Chemo-enzymatic synthesis of allyl penta- N-acetyl-chitopentaose
score: 1.3165449, Bioorganic & Medicinal Chemistry Letters, 2006, Huang, Gang-Liang et. al.
Interaction of the new ketolide ABT-773 (cethromycin) with human polymorphonuclear neutrophils and the phagocytic cell line PLB-985 in vitro.
score: 1.3164533, Antimicrobial agents and chemotherapy, 2004, Labro, Marie Thérèse et. al.
Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu
score: 1.3163274, Bioorganic & Medicinal Chemistry Letters, 2013, Eid, Assaad A. et. al.
Microbial transformation of baccatin VI and 1β-Hydroxy baccatin I by aspergillus niger
score: 1.3162678, Bioorganic & Medicinal Chemistry Letters, 2003, Shen, Ya-Ching et. al.
Synthesis, characterization and cytotoxicity of platinum(II)/palladium(II) complexes with 1, 3-diaminopropane and 4-toluensulfonyl-L-amino acid dianion
score: 1.3162491, European Journal of Medicinal Chemistry, 2012, Zhang, Jinchao et. al.
Semisynthesis and cytotoxicity of amino acetogenins and derivatives
score: 1.3162054, Bioorganic & Medicinal Chemistry, 1999, Duret, Philippe et. al.
Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations.
score: 1.3161816, Antimicrobial agents and chemotherapy, 2002, Carryn, Stéphane et. al.
Tetrahedron Young Investigator Award 2008
score: 1.3161382, Bioorganic & Medicinal Chemistry Letters, 2008, Cravatt, Benjamin F.
Quantitative structure–Activity relationship studies on some nonbenzodiazepine series of compounds acting at the benzodiazepine receptor
score: 1.3160959, Bioorganic & Medicinal Chemistry, 1998, Gupta, S.P.; Paleti, Anitha
Has the Emergence of Community-Associated Methicillin-Resistant Staphylococcus aureus Increased Trimethoprim-Sulfamethoxazole Use and Resistance?: a 10-Year Time Series Analysis.
score: 1.3160083, Antimicrobial agents and chemotherapy, 2012, Wood, Jameson B et. al.
Catechol derivatives of aminopyrazine and cell protection against uvb-induced mortality
score: 1.3160029, Bioorganic & Medicinal Chemistry, 2001, Cavalier, Jean-François et. al.
In vitro antibacterial activities of DQ-113, a potent quinolone, against clinical isolates.
score: 1.3158903, Antimicrobial agents and chemotherapy, 2002, Tanaka, Mayumi et. al.
A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca
score: 1.3157893, Bioorganic & Medicinal Chemistry Letters, 2012, Awakawa, Takayoshi et. al.
A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca
score: 1.3157893, Bioorganic & Medicinal Chemistry Letters, 2012, Awakawa, Takayoshi et. al.
A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca
score: 1.3157893, Bioorganic & Medicinal Chemistry Letters, 2012, Awakawa, Takayoshi et. al.
Inhibition of class D beta-lactamases by acyl phosphates and phosphonates.
score: 1.3157215, Antimicrobial agents and chemotherapy, 2005, Adediran, S A et. al.
Staphylococcus aureus cell extract transcription-translation assay: firefly luciferase reporter system for evaluating protein translation inhibitors.
score: 1.3156567, Antimicrobial agents and chemotherapy, 2001, Murray, R W; Melchior, E P; Hagadorn, J C; Marotti, K R
Highly potent inhibitors of tnf- α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer
score: 1.3156244, Bioorganic & Medicinal Chemistry, 2002, Matsui, Toshiaki et. al.
Haemophilus influenzae bla(ROB-1) mutations in hypermutagenic deltaampC Escherichia coli conferring resistance to cefotaxime and beta-lactamase inhibitors and increased susceptibility to cefaclor.
score: 1.3155965, Antimicrobial agents and chemotherapy, 2003, Galán, Juan-Carlos et. al.
Synthesis and application of a new 2′,3′-isopropylidene guanosine substituted cap analog
score: 1.3154774, Bioorganic & Medicinal Chemistry Letters, 2008, Kore, Anilkumar R. et. al.
A combined NMR and molecular dynamics simulation study to determine the conformational properties of agonists and antagonists against experimental autoimmune encephalomyelitis
score: 1.3154244, Bioorganic & Medicinal Chemistry, 2008, Mantzourani, Efthimia D. et. al.
Synthesis and study of antibacterial and antifungal activities of novel 1-[2-(benzoxazol-2-yl)ethoxy]- 2,6-diarylpiperidin-4-ones
score: 1.315313, European Journal of Medicinal Chemistry, 2004, Ramalingan, C. et. al.
In vivo activities of peptidic prodrugs of novel aminomethyl tetrahydrofuranyl-1 beta-methylcarbapenems.
score: 1.3152902, Antimicrobial agents and chemotherapy, 1999, Weiss, W J et. al.
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of iminoacid residues
score: 1.3152527, Bioorganic & Medicinal Chemistry, 1996, Le, Hoang-Thanh et. al.
Solution NMR analysis of the binding mechanism of DIVS6 model peptides of voltage-gated sodium channels and the lipid soluble alkaloid veratridine
score: 1.3152067, Bioorganic & Medicinal Chemistry, 2012, Yoshinaka-Niitsu, Ai et. al.
Solution NMR analysis of the binding mechanism of DIVS6 model peptides of voltage-gated sodium channels and the lipid soluble alkaloid veratridine
score: 1.3152067, Bioorganic & Medicinal Chemistry, 2012, Yoshinaka-Niitsu, Ai et. al.
Solution NMR analysis of the binding mechanism of DIVS6 model peptides of voltage-gated sodium channels and the lipid soluble alkaloid veratridine
score: 1.3152067, Bioorganic & Medicinal Chemistry, 2012, Yoshinaka-Niitsu, Ai et. al.
Hsp90 inhibition: Elimination of shock and stress
score: 1.3151438, Bioorganic & Medicinal Chemistry Letters, 2010, Duerfeldt, Adam S.; Blagg, Brian S.J.
Synthesis of methyl (5 S,6 R,7 E,9 E,11 Z,13 E,15 S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15 R-Lipoxin A 4
score: 1.3151231, Bioorganic & Medicinal Chemistry Letters, 2003, Phillips, Eifion D et. al.
The anandamide membrane transporter. Structure–activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region
score: 1.3151226, Bioorganic & Medicinal Chemistry, 2004, Di Marzo, Vincenzo et. al.
G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay
score: 1.3151038, Bioorganic & Medicinal Chemistry, 2012, Schoonover, Michelle; Kerwin, Sean M.
In vitro study of some medicinally important Mannich bases derived from antitubercular agent
score: 1.315099, Bioorganic & Medicinal Chemistry, 2004, Joshi, Sheela; Khosla, Navita; Tiwari, Prapti
Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureus.
score: 1.3150426, Antimicrobial agents and chemotherapy, 1997, Entenza, J M; Vouillamoz, J; Glauser, M P; Moreillon, P
Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294A2 Biosynthetic Gene Cluster from Lysobacter enzymogenes OH11.
score: 1.3150345, Antimicrobial agents and chemotherapy, 2011, Zhang, Wei et. al.
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production
score: 1.3149709, Bioorganic & Medicinal Chemistry Letters, 2012, Pham, Tuan-Ahn. N. et. al.
A novel method to highly versatile monomeric PNA building blocks by multi component reactions
score: 1.3149262, Bioorganic & Medicinal Chemistry Letters, 1999, Dömling, Alexander; Chi, Kai-Zu; Barrère, Mathieux
Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding
score: 1.3147771, Bioorganic & Medicinal Chemistry, 2005, Burnett, James C. et. al.
Syntheses and Cytotoxicities of Four Stereoisomers of Muricatacin from d-Glucose
score: 1.3145058, Bioorganic & Medicinal Chemistry, 1998, Yoon, Sung-Hwa et. al.
Synthesis and biological evaluation of penam sulfones as inhibitors of β-lactamases
score: 1.3144496, Bioorganic & Medicinal Chemistry, 2005, Phillips, Oludotun A. et. al.
Exploring the molecular mechanism of karrikins and strigolactones
score: 1.3143794, Bioorganic & Medicinal Chemistry Letters, 2012, Scaffidi, Adrian et. al.
Exploring the molecular mechanism of karrikins and strigolactones
score: 1.3143794, Bioorganic & Medicinal Chemistry Letters, 2012, Scaffidi, Adrian et. al.
Synthesis, molecular modeling and QSAR studies in chiral 2,3-disubstituted-1,2,3,4-tetrahydro-9H-pyrido(3,4-b)indoles as potential modulators of opioid antinociception
score: 1.3143284, Bioorganic & Medicinal Chemistry, 2001, Saxena, Anil K et. al.
Synthesis and pharmacological characterization of a new benzoxazole derivative as a potent 5-HT 3 receptor agonist
score: 1.314311, Bioorganic & Medicinal Chemistry, 2003, López-Tudanca, Pedro Luis et. al.
Enzymatic fucosylations of non-natural sialylated type-I trisaccharides with recombinant fucosyl-transferase-III
score: 1.3142382, Bioorganic & Medicinal Chemistry Letters, 1998, Baisch, Gabi; Öhrlein, Reinhold; Streiff, Markus
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities
score: 1.3142084, Bioorganic & Medicinal Chemistry Letters, 2012, Cho, Jun-Cheol et. al.
Chemo- and enzymatic synthesis of partially and fully N-deacetylated 4-methylumbelliferyl chitobiosides: Fluorogenic substrates for chitinase
score: 1.3141815, Bioorganic & Medicinal Chemistry Letters, 2000, Honda, Yuji et. al.
A mechanism based protein crosslinker for acyl carrier protein dehydratases
score: 1.3141628, Bioorganic & Medicinal Chemistry Letters, 2010, Meier, Jordan L.; Haushalter, Robert W.; Burkart, Michael D.
Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus.
score: 1.3141349, Antimicrobial agents and chemotherapy, 2011, Naughtin, M et. al.
Fluorescence ‘on-off-on’ chemosensor for sequential recognition of Fe3+ and Hg2+ in water based on tetraphenylethylene motif
score: 1.313986, Bioorganic & Medicinal Chemistry, 2013, Yan, Yuanyuan et. al.
Antistaphylococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents.
score: 1.3139581, Antimicrobial agents and chemotherapy, 2004, Credito, Kim et. al.
Synthesis and antibacterial evaluation of [1,3]benzothiazino[3,2- a]quinoline- and [3,1]benzothiazino[1,2- a]quinoline-6-carboxylic acid derivatives
score: 1.3138485, Bioorganic & Medicinal Chemistry, 1997, Cecchetti, Violetta et. al.
The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines
score: 1.313781, European Journal of Medicinal Chemistry, 2009, Chan, Sau Hing et. al.
In vitro activity of gallium maltolate against Staphylococci in logarithmic, stationary, and biofilm growth phases: comparison of conventional and calorimetric susceptibility testing methods.
score: 1.3137761, Antimicrobial agents and chemotherapy, 2010, Baldoni, Daniela et. al.
Peroxides as oxidative enzyme inhibitors: Mechanism-based inhibition of a cysteine protease by an amino acid ozonide
score: 1.3137407, Bioorganic & Medicinal Chemistry Letters, 1999, Dussault, Patrick H.; Denise George, A.; Trullinger, Tony K.
Dicationic pyridium porphyrins appending different peripheral substituents: Synthesis and studies for their interactions with DNA
score: 1.3137152, Bioorganic & Medicinal Chemistry, 2006, Wu, Song et. al.
Facile regioselective synthesis of novel bioactive thiazolyl-pyrazoline derivatives via a three-component reaction and their antimicrobial activity
score: 1.3135196, Bioorganic & Medicinal Chemistry Letters, 2013, Sharifzadeh, Bahman et. al.
Fluorescent analysis of excess electron transfer through DNA
score: 1.3134716, Bioorganic & Medicinal Chemistry Letters, 2010, Takada, Tadao et. al.
Synthesis and binding properties of novel selective 5-HT 3 receptor ligands
score: 1.3132681, Bioorganic & Medicinal Chemistry, 2004, Modica, Maria et. al.
[3-(1 H-Imidazol-4-yl)propyl]guanidines containing furoxan moieties
score: 1.3131395, Bioorganic & Medicinal Chemistry, 2003, Bertinaria, Massimo et. al.
DNA-interaction and in vitro antimicrobial studies of some mixed-ligand complexes of cobalt(II) with fluoroquinolone antibacterial agent ciprofloxacin and some neutral bidentate ligands
score: 1.313118, Bioorganic & Medicinal Chemistry Letters, 2009, Patel, M.N.; Chhasatia, M.R.; Gandhi, D.S.
Mechanistic aspects of transport antibiotics
score: 1.3130501, European Journal of Medicinal Chemistry, 2010, Banerjee, A.; Yadav, A.
Pharmacodynamics of a new streptogramin, XRP 2868, in murine thigh and lung infection models.
score: 1.3129154, Antimicrobial agents and chemotherapy, 2006, Andes, D; Craig, W A
Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists
score: 1.312911, Bioorganic & Medicinal Chemistry Letters, 2012, Dzierba, Carolyn D. et. al.
QSAR analysis of diaryl COX-2 inhibitors: Comparison of feature selection and train-test data selection methods
score: 1.312836, European Journal of Medicinal Chemistry, 2010, Soltani, Somaieh et. al.
QSAR analysis of diaryl COX-2 inhibitors: Comparison of feature selection and train-test data selection methods
score: 1.312836, European Journal of Medicinal Chemistry, 2010, Soltani, Somaieh et. al.
Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups
score: 1.3127962, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Qi et. al.
Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups
score: 1.3127962, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Qi et. al.
Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups
score: 1.3127962, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Qi et. al.
Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups
score: 1.3127962, Bioorganic & Medicinal Chemistry Letters, 2012, Jin, Qi et. al.
Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors
score: 1.3126418, European Journal of Medicinal Chemistry, 2012, N'gompaza-Diarra, Joannah et. al.
Synthesis and topoisomerase I inhibitory properties of luotonin A analogues
score: 1.3125902, Bioorganic & Medicinal Chemistry, 2004, Cagir, Ali et. al.
Identification of C10 biotinylated camptothecin (CPT-10-B) binding peptides using T7 phage display screen on a QCM device
score: 1.3124137, Bioorganic & Medicinal Chemistry, 2007, Takakusagi, Yoichi et. al.
Paraoxonases as potential antibiofilm agents: their relationship with quorum-sensing signals in Gram-negative bacteria.
score: 1.3124106, Antimicrobial agents and chemotherapy, 2011, Camps, Jordi et. al.
Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants
score: 1.3123691, Bioorganic & Medicinal Chemistry, 2005, Bhandari, Kalpana et. al.
Studies on the cytochrome P450 catalyzed oxidation of 13C labeled 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine by 13C NMR
score: 1.3121213, Bioorganic & Medicinal Chemistry, 2005, Bissel, Philippe; Castagnoli, Neal
Synthesis and evaluation of antifungal activity of naphthoquinone derivatives
score: 1.312119, European Journal of Medicinal Chemistry, 2006, Errante, Giaccomo et. al.
Precursor-Directed polyketide biosynthesis in Escherichia coli
score: 1.3121076, Bioorganic & Medicinal Chemistry Letters, 2003, Kinoshita, Kenji et. al.
Simultaneous detection of alkaline phosphatase and β-galactosidase activity using SERRS
score: 1.3120695, Bioorganic & Medicinal Chemistry Letters, 2009, Ingram, Andrew; Moore, Barry D.; Graham, Duncan
Synthesis of new arylalkoxy amido derivatives as melatoninergic ligands
score: 1.3118108, Bioorganic & Medicinal Chemistry, 2003, Pégurier, Cécile et. al.
New inhibitors of the malaria aspartyl proteases plasmepsin I and II
score: 1.3117504, Bioorganic & Medicinal Chemistry, 2003, Dahlgren, Anders et. al.
Absolute Stereostructure of Potent α-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata
score: 1.3116261, Bioorganic & Medicinal Chemistry, 2002, Yoshikawa, Masayuki et. al.
Novel class A beta-lactamase Sed-1 from Citrobacter sedlakii: genetic diversity of beta-lactamases within the Citrobacter genus.
score: 1.3115694, Antimicrobial agents and chemotherapy, 2001, Petrella, S; Clermont, D; Casin, I; Jarlier, V; Sougakoff, W
Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin
score: 1.3115144, Bioorganic & Medicinal Chemistry Letters, 2001, Sharma, Sanjay K. et. al.
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.
score: 1.3115036, Antimicrobial agents and chemotherapy, 2006, Magarvey, Nathan A et. al.
A method for the synthesis of an oseltamivir PET tracer
score: 1.3113704, Bioorganic & Medicinal Chemistry Letters, 2008, Morita, Masataka et. al.
Chemoenzymatic deacylation of ramoplanin
score: 1.3112393, Bioorganic & Medicinal Chemistry Letters, 2012, Gandolfi, Raffaella et. al.
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors
score: 1.3111393, Bioorganic & Medicinal Chemistry Letters, 2012, Mangin, Floriane et. al.
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1Aversus D4 receptors
score: 1.3111393, Bioorganic & Medicinal Chemistry Letters, 2012, Mangin, Floriane et. al.
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors
score: 1.3111393, Bioorganic & Medicinal Chemistry Letters, 2012, Mangin, Floriane et. al.
3D QSAR study of hypolipidemic asarones by comparative molecular surface analysis
score: 1.3110158, Bioorganic & Medicinal Chemistry, 2006, Magdziarz, Tomasz et. al.
Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide.
score: 1.3109037, Antimicrobial agents and chemotherapy, 2012, de la Fuente-Núñez, César et. al.
Preparation and photophysical properties of a caged kynurenine
score: 1.310814, Bioorganic & Medicinal Chemistry Letters, 2012, Maitrani, Chandan et. al.
Enzymatic syntheses of 6-(4H-Selenolo[3,2- b]pyrrolyl)-L-alanine, 4-(6H-selenolo[2,3- b]pyrrolyl)-L-alanine, and 6-(4H-furo[3,2- b]pyrrolyl)-L-alanine
score: 1.3108098, Bioorganic & Medicinal Chemistry Letters, 1999, Welch, Michael; Phillips, Robert S.
Synthesis of some novel benzoxazole derivatives as anticancer, anti-HIV-1 and antimicrobial agents
score: 1.3107744, European Journal of Medicinal Chemistry, 2005, Rida, Samia M. et. al.
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.
score: 1.3107472, Antimicrobial agents and chemotherapy, 2011, Gregory, Matthew A et. al.
Discovery of diaminobutane derivatives as Ca 2+-permeable AMPA receptor antagonists
score: 1.3107052, Bioorganic & Medicinal Chemistry, 2002, Yoneda, Yoshiyuki et. al.
Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1
score: 1.3106495, Bioorganic & Medicinal Chemistry, 2012, De Simone, Rosa et. al.
Regiospecific Synthesis of 2,3-Disubstituted- l-Histidines and Histamines
score: 1.3104158, Bioorganic & Medicinal Chemistry Letters, 2001, Narayanan, Sanju; Vangapandu, Suryanarayana; Jain, Rahul
Synthesis and biological activity of isoprenoid bisphosphonates
score: 1.3101554, Bioorganic & Medicinal Chemistry, 2006, Shull, Larry W. et. al.
Synthesis and receptor binding studies of 3-substituted piperazine derivatives
score: 1.3101426, European Journal of Medicinal Chemistry, 2006, Bedürftig, Stephan; Wünsch, Bernhard
β 3-Adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-{[(1 S,2 R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionic acid
score: 1.3101366, Bioorganic & Medicinal Chemistry, 2001, Tanaka, Nobuyuki et. al.
In vitro activity of ceftaroline against a broad spectrum of recent clinical anaerobic isolates.
score: 1.3100993, Antimicrobial agents and chemotherapy, 2011, Snydman, David R; Jacobus, Nilda V; McDermott, Laura A
Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives
score: 1.3100282, European Journal of Medicinal Chemistry, 2006, Saitoh, Toshiaki et. al.
Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells
score: 1.309994, European Journal of Medicinal Chemistry, 2012, Khelili, Smail et. al.
Protection of a single-cysteine redox switch from oxidative destruction: On the functional role of sulfenyl amide formation in the redox-regulated enzyme PTP1B
score: 1.309842, Bioorganic & Medicinal Chemistry Letters, 2010, Sivaramakrishnan, Santhosh et. al.
Synthesis and antagonistic activity at muscarinic receptor subtypes of some 2-carbonyl derivatives of diphenidol
score: 1.3097488, Bioorganic & Medicinal Chemistry, 1999, Varoli, Lucilla et. al.
Engineered production of iso-migrastatin in heterologous Streptomyces hosts
score: 1.3097095, Bioorganic & Medicinal Chemistry, 2009, Feng, Zhiyang et. al.
Determination of intracellular pH using sensitive, clickable fluorescent probes
score: 1.3096135, Bioorganic & Medicinal Chemistry Letters, 2012, Yapici, Nazmiye B. et. al.
Pharmacophore-based small molecule CXCR4 ligands
score: 1.3095682, Bioorganic & Medicinal Chemistry Letters, 2012, Narumi, Tetsuo et. al.
Pharmacophore-based small molecule CXCR4 ligands
score: 1.3095682, Bioorganic & Medicinal Chemistry Letters, 2012, Narumi, Tetsuo et. al.
Macrocyclic proteoglycan mimics. Potent inhibition of cell adhesion by a bundle of chondroitin sulfate chains assembled on the calix[4]resorcarene platform
score: 1.3094418, Bioorganic & Medicinal Chemistry Letters, 2004, Tomita, Naotoshi et. al.
Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides
score: 1.3094253, Bioorganic & Medicinal Chemistry, 2013, Pastore, Valentina et. al.
An orthogonal purification strategy for isolating crosslinked domains of modular synthases
score: 1.3093935, Bioorganic & Medicinal Chemistry Letters, 2008, Haushalter, Robert W. et. al.
Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I
score: 1.30939, Bioorganic & Medicinal Chemistry Letters, 2007, Li, Xinming et. al.
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme
score: 1.3093433, European Journal of Medicinal Chemistry, 2012, Biava, Mariangela et. al.
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme
score: 1.3093433, European Journal of Medicinal Chemistry, 2012, Biava, Mariangela et. al.
Construction of saccharide-modified DNAs by DNA polymerase
score: 1.3090556, Bioorganic & Medicinal Chemistry Letters, 2007, Matsui, Masayuki et. al.
Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles
score: 1.3090436, European Journal of Medicinal Chemistry, 2012, Moineaux, Laurence et. al.
Model system to evaluate the effect of ampD mutations on AmpC-mediated beta-lactam resistance.
score: 1.3090014, Antimicrobial agents and chemotherapy, 2006, Schmidtke, Amber J; Hanson, Nancy D
Gallium(III) complexes of methyl pyropheophorbide- a as synthetic models for investigation of diastereomerically controlled axial ligation towards chlorophylls
score: 1.308854, Bioorganic & Medicinal Chemistry Letters, 2006, Sasaki, Shin-ichi; Mizoguchi, Tadashi; Tamiaki, Hitoshi
Synthesis of a new fluorogenic substrate for the continuous assay of mammalian phosphoinositide-specific phospholipase C
score: 1.3087154, Bioorganic & Medicinal Chemistry Letters, 1999, Rukavishnikov, Aleksey V. et. al.
Lipase-mediated stereoselective hydrolysis of stampidine and other phosphoramidate derivatives of stavudine
score: 1.308682, Bioorganic & Medicinal Chemistry, 2004, Venkatachalam, T.K et. al.
Assessment of the sequence dependency for the binding of 2-aminonaphthyridine to the guanine bulge
score: 1.3086738, Bioorganic & Medicinal Chemistry, 2003, Nakatani, Kazuhiko et. al.
Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents
score: 1.3085691, European Journal of Medicinal Chemistry, 2006, Cope, H. et. al.
A mechanistic study of 3-aminoindazole cyclic urea HIV-1 protease inhibitors using comparative QSAR
score: 1.3084655, Bioorganic & Medicinal Chemistry, 2004, Garg, Rajni; Bhhatarai, Barun
Target identification of bioactive compounds
score: 1.3083668, Bioorganic & Medicinal Chemistry, 2012, Tashiro, Etsu; Imoto, Masaya
A new family of potential oncostatics: 2-chloroethylnitrososulfamides (CENS)—I. Synthesis, structure, and pharmacological evaluation (preliminary results)
score: 1.3082588, Bioorganic & Medicinal Chemistry, 1996, Abdaoui, Mohamed et. al.
Synthesis and pharmacology of Alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor
score: 1.3082397, Bioorganic & Medicinal Chemistry, 1996, Villarroya, Mercedes et. al.
Impact of protein binding cavity volume (PCV) and ligand volume (LV) in rigid and flexible docking of Protein-ligand complexes
score: 1.3082005, Bioorganic & Medicinal Chemistry Letters, 2012, Saranya, N.; Jeyakanthan, J.; Selvaraj, S.
Hydrolysis spectrum extension of CMY-2-like β-lactamases resulting from structural alteration in the Y-X-N loop.
score: 1.3081887, Antimicrobial agents and chemotherapy, 2012, Dahyot, Sandrine; Mammeri, Hedi
Synthetic inhibitors of regulatory proteins involved in the signaling pathway of the replication of human immunodeficiency virus 1
score: 1.3080161, Bioorganic & Medicinal Chemistry, 1997, Otsuka, Masami et. al.
Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA)
score: 1.3079924, Bioorganic & Medicinal Chemistry, 2012, Nozaki, Emi et. al.
Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA)
score: 1.3079924, Bioorganic & Medicinal Chemistry, 2012, Nozaki, Emi et. al.
Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA)
score: 1.3079924, Bioorganic & Medicinal Chemistry, 2012, Nozaki, Emi et. al.
A fluorogenic and chromogenic probe that detects the esterase activity of trace copper(II)
score: 1.3079664, Bioorganic & Medicinal Chemistry Letters, 2005, Kierat, Radoslaw M.; Krämer, Roland
Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases
score: 1.3079637, Bioorganic & Medicinal Chemistry, 2005, Ganesh, Vannakambadi K. et. al.
Synthesis and biological activities of phenylahistin derivatives
score: 1.307932, Bioorganic & Medicinal Chemistry, 1999, Kanoh, Kaneo et. al.
Experimental chemotherapy against Trypanosoma cruzi infection using ruthenium nitric oxide donors.
score: 1.307924, Antimicrobial agents and chemotherapy, 2009, Silva, Jean Jerley N et. al.
Synthesis and in vitro biological evaluation of fluoro-substituted-4-phenyl-1,2,3,6-tetrahydropyridines as monoamine oxidase B substrates
score: 1.3078787, Bioorganic & Medicinal Chemistry, 2003, Beeler, Aaron B et. al.
Anticancer activity of dinuclear gallium(III) carboxylate complexes
score: 1.3078694, European Journal of Medicinal Chemistry, 2010, Kaluđerović, Milena R. et. al.
Binding of oxalyl derivatives of β- d-glucopyranosylamine to muscle glycogen phosphorylase b
score: 1.307821, Bioorganic & Medicinal Chemistry, 2006, Hadjiloi, Theodoros et. al.
Preparation and in vitro photodynamic activity of amphiphilic zinc(II) phthalocyanines substituted with 2-(dimethylamino)ethylthio moieties and their N-alkylated derivatives
score: 1.307719, Bioorganic & Medicinal Chemistry, 2010, Duan, Wubiao et. al.
Caulerpenyne–colchicine hybrid: Synthesis and biological evaluation
score: 1.3074306, Bioorganic & Medicinal Chemistry, 2006, Bourdron, Julien et. al.
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D 3 receptor ligands
score: 1.3072724, Bioorganic & Medicinal Chemistry, 2005, Chu, Wenhua et. al.
Polymorphism in plasmodium falciparum drug transporter proteins and reversal of in vitro chloroquine resistance by a 9,10-dihydroethanoanthracene derivative.
score: 1.3072396, Antimicrobial agents and chemotherapy, 2004, Millet, Julie et. al.
Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors.
score: 1.3072259, Antimicrobial agents and chemotherapy, 2000, Henry, K W; Nickels, J T; Edlind, T D
Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl-methylenecyclopentanone hydrochlorides and related compounds
score: 1.3071689, Bioorganic & Medicinal Chemistry, 2005, Wang, Jingli et. al.
Antimalarial activity of allicin, a biologically active compound from garlic cloves.
score: 1.3070596, Antimicrobial agents and chemotherapy, 2006, Coppi, Alida et. al.
MupB, a new high-level mupirocin resistance mechanism in Staphylococcus aureus.
score: 1.3070378, Antimicrobial agents and chemotherapy, 2012, Seah, Christine et. al.
Antibiotic inhibitors of the peptidyl transferase center. 1. clindamycin as a composite analogue of the transfer RNA fragments L-Pro-Met and the D-ribosyl ring of adenosine
score: 1.3070102, Bioorganic & Medicinal Chemistry Letters, 1998, Fitzhugh, Anthony L
A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src
score: 1.3069948, Bioorganic & Medicinal Chemistry, 1998, Liu, Y.; Shah, K.; Yang, F.; Witucki, L.; Shokat, K.M.
Development of siRNA for therapeutics: Efficient synthesis of phosphorothioate RNA utilizing phenylacetyl disulfide (PADS)
score: 1.3068686, Bioorganic & Medicinal Chemistry Letters, 2006, Ravikumar, Vasulinga T. et. al.
Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles
score: 1.3067223, European Journal of Medicinal Chemistry, 2012, Moineaux, Laurence et. al.
Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure–activity relationship of potent inhibitory activity against DNA topoisomerase I
score: 1.3063456, Bioorganic & Medicinal Chemistry, 2006, Zhang, Shixuan et. al.
Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats
score: 1.3062938, Bioorganic & Medicinal Chemistry Letters, 2004, Lugar, Charles W. et. al.
Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives
score: 1.3062697, Bioorganic & Medicinal Chemistry Letters, 2009, Cai, Li et. al.
Specific sensing between inositol epimers by a bis(boronate)
score: 1.3061914, Bioorganic & Medicinal Chemistry Letters, 2005, Gray, Charles W. et. al.
Homology modeling and docking study of cyclin-dependent kinase (CDK) 10
score: 1.3061779, Bioorganic & Medicinal Chemistry Letters, 2005, Sun, Miao et. al.
Synthesis and biological activity of novel mycophenolic acid conjugates containing Nitro-acridine/acridone derivatives
score: 1.3061464, European Journal of Medicinal Chemistry, 2012, Malachowska-Ugarte, Magdalena et. al.
S-Adenosyl-L-methionine inhibitors delta(24)-sterol methyltransferase and delta(24(28))-sterol methylreductase as possible agents against Paracoccidioides brasiliensis.
score: 1.3061463, Antimicrobial agents and chemotherapy, 2003, Visbal, Gonzalo et. al.
Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207
score: 1.3061413, Bioorganic & Medicinal Chemistry, 2003, Crasto, Curtis F et. al.
A TOPS-MODE approach to predict affinity for A 1 adenosine receptors. 2-(Arylamino)adenosine analogues
score: 1.3061004, Bioorganic & Medicinal Chemistry, 2004, González, Maykel Pérez; del Carmen Terán Moldes, Maria
Synthesis and vasorelaxing evaluation of α-methylidene-γ-butyrolactone bearing quinolin-2(1 H)-one and 3,4-dihydroquinolin-2(1 H)-one derivatives
score: 1.3060094, European Journal of Medicinal Chemistry, 2001, Wang, Tai-Chi; Zhao, Yue-Ling; Kuo, Daih-Huang
Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants
score: 1.3059971, European Journal of Medicinal Chemistry, 2012, Perković, I. et. al.
Pyrene-labeled deoxyguanosine as a fluorescence sensor to discriminate single and double stranded DNA structures: Design of ends free molecular beacons
score: 1.3059119, Bioorganic & Medicinal Chemistry Letters, 2009, Matsumoto, Katsuhiko et. al.
Synthesis, properties, and photodynamic properties in vitro of heavy-chalcogen analogues of tetramethylrosamine
score: 1.3058964, Bioorganic & Medicinal Chemistry, 2004, Detty, Michael R et. al.
Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use.
score: 1.3058719, Antimicrobial agents and chemotherapy, 2006, Monto, Arnold S et. al.
In vivo efficacy and pharmacokinetics of AC98-6446, a novel cyclic glycopeptide, in experimental infection models.
score: 1.3058153, Antimicrobial agents and chemotherapy, 2004, Weiss, William J et. al.
Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis
score: 1.3058072, Bioorganic & Medicinal Chemistry, 2005, Su, Jing et. al.
Identification of BPR3P0128 as an inhibitor of cap-snatching activities of influenza virus.
score: 1.3056435, Antimicrobial agents and chemotherapy, 2012, Hsu, John T-A et. al.
A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5)
score: 1.3056163, European Journal of Medicinal Chemistry, 2008, Ravna, Aina Westrheim; Sylte, Ingebrigt; Sager, Georg
Worldwide appraisal and update (2010) of telavancin activity tested against a collection of Gram-positive clinical pathogens from five continents.
score: 1.3055682, Antimicrobial agents and chemotherapy, 2012, Mendes, Rodrigo E et. al.
New anticancer bastadin alkaloids from the sponge Dendrilla cactos
score: 1.3054522, Bioorganic & Medicinal Chemistry, 2006, Reddy, A. Vijender et. al.
Specific Interactions between Adenosine and Streptavidin/Avidin
score: 1.3051332, Bioorganic & Medicinal Chemistry Letters, 2012, Bing, Tao et. al.
Design, synthesis and in vitro activities on anti-platelet aggregation of 4-methoxybenzene-1,3-isophthalamides
score: 1.304948, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Xiu Jie et. al.
Design, synthesis and in vitro activities on anti-platelet aggregation of 4-methoxybenzene-1,3-isophthalamides
score: 1.304948, Bioorganic & Medicinal Chemistry Letters, 2012, Liu, Xiu Jie et. al.
Studies on selectin blocker. 9. SARs of non-sugar selectin blocker against E-, P-, L-selectin bindings
score: 1.3049442, Bioorganic & Medicinal Chemistry, 2001, Moriyama, Hideki et. al.
Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease
score: 1.3049388, Bioorganic & Medicinal Chemistry Letters, 2012, Duan, Maosheng et. al.
Synthesis and DNA-binding affinities of monomodified berberines
score: 1.3049291, Bioorganic & Medicinal Chemistry, 2005, Pang, Ji-Yan et. al.
Synthesis and muscarinic M 3 pharmacological activities of 1-azabicyclo[2.2.2]octan-3-one oxime derivatives
score: 1.3047668, Bioorganic & Medicinal Chemistry, 1996, Plate, Ralf et. al.
Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon
score: 1.3047543, Bioorganic & Medicinal Chemistry, 2003, Saito, Yoshio et. al.
Type III collagen mimetic peptides designed with anti- or pro-aggregant activities on human platelets
score: 1.3046505, European Journal of Medicinal Chemistry, 2007, Pires, Viviane et. al.
Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials
score: 1.3046124, European Journal of Medicinal Chemistry, 2010, Ojha, Probir Kumar; Roy, Kunal
Novel glycosylation reactions using glycosyl thioimidates of N-acetylneuraminic acid as sialyl donors
score: 1.3044056, Bioorganic & Medicinal Chemistry Letters, 2006, Ikeda, Kiyoshi; Aizawa, Misato; Sato, Kazuki; Sato, Masayuki
An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues
score: 1.3042139, Bioorganic & Medicinal Chemistry Letters, 2002, Tanimori, Shinji; Ohta, Takeshi; Kirihata, Mitsunori
Novel hydroxyphenylurea dual inhibitor against Acyl-CoA
score: 1.3040862, Bioorganic & Medicinal Chemistry, 2001, Nakao, Kazuya et. al.
Efficacy of Telavancin in a rabbit model of aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus or vancomycin-intermediate Staphylococcus aureus.
score: 1.3039294, Antimicrobial agents and chemotherapy, 2005, Madrigal, Andres G; Basuino, Li; Chambers, Henry F
A convenient synthetic pathway for multivalent assembly of aminoglycoside antibiotics starting from amikacin
score: 1.3037785, Bioorganic & Medicinal Chemistry Letters, 2002, Tanaka, Hidehiko et. al.
Quinolone-mediated bacterial death.
score: 1.3037606, Antimicrobial agents and chemotherapy, 2008, Drlica, Karl; Malik, Muhammad; Kerns, Robert J; Zhao, Xilin
Synthesis, self-aggregation and bioactivity properties of a cationic aminoacyl surfactant, based on a new class of highly functionalized nucleolipids
score: 1.3037341, European Journal of Medicinal Chemistry, 2012, Simeone, Luca et. al.
Synthesis, self-aggregation and bioactivity properties of a cationic aminoacyl surfactant, based on a new class of highly functionalized nucleolipids
score: 1.3037341, European Journal of Medicinal Chemistry, 2012, Simeone, Luca et. al.
Study on synthesis, characterization and biological activity of some new nitrogen heterocycle porphyrins
score: 1.3037015, Bioorganic & Medicinal Chemistry, 2003, Guo, Can-Cheng; Li, He-Ping; Zhang, Xiao-Bing
Muscarinic thioligands with cyclopentane nucleus
score: 1.3036837, Bioorganic & Medicinal Chemistry, 1996, Piergentili, Alessandro et. al.
Studies on inhibition mechanism of transcription factor NF-κB and DNA binding by chelator pyrogallol red on the basis of its interaction with metal ions
score: 1.3036813, Bioorganic & Medicinal Chemistry, 2008, Sharma, R.K. et. al.
Cytotoxic activity of ( S)-goniothalamin and analogues against human cancer cells
score: 1.3035991, Bioorganic & Medicinal Chemistry, 2006, de Fátima, Ângelo et. al.
Synthesis of novel octa-cationic and non-ionic 1,2-ethanediamine substituted zinc (Ⅱ) phthalocyanines and their in vitro anti-cancer activity comparison
score: 1.3035945, European Journal of Medicinal Chemistry, 2012, Wang, Ao et. al.
Synthesis of novel octa-cationic and non-ionic 1,2-ethanediamine substituted zinc (Ⅱ) phthalocyanines and their in vitro anti-cancer activity comparison
score: 1.3035945, European Journal of Medicinal Chemistry, 2012, Wang, Ao et. al.
Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity
score: 1.3034323, European Journal of Medicinal Chemistry, 2012, Cui, Yanli et. al.
Total synthesis of grassystatin A, a probe for cathepsin E function
score: 1.3033913, Bioorganic & Medicinal Chemistry, 2012, Yang, Siming et. al.
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors
score: 1.3033908, European Journal of Medicinal Chemistry, 2012, Liu, Jingbao et. al.
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors
score: 1.3033908, European Journal of Medicinal Chemistry, 2012, Liu, Jingbao et. al.
Ring-substituted 11-oxo-11 H-indeno[1,2- b]quinoline-6-carboxamides with similar patterns of cytotoxicity to the dual topo I/II inhibitor DACA
score: 1.3033486, Bioorganic & Medicinal Chemistry, 1999, Deady, Leslie W. et. al.
QSAR Study on 13C NMR chemical shifts on carbinol carbon atoms
score: 1.3029971, Bioorganic & Medicinal Chemistry, 2004, Jaiswal, Mona; Khadikar, Padmakar
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter
score: 1.3029868, Bioorganic & Medicinal Chemistry, 2000, Meltzer, Peter C. et. al.
Antiviral activity and synthesis of quaternized promazine derivatives against HSV-1
score: 1.3029669, Bioorganic & Medicinal Chemistry Letters, 2012, Purohit, Akasha K. et. al.
Evaluation of resins for on-bead screening: A study of papain and chymotrypsin specificity using pega-bound combinatorial peptide libraries
score: 1.3028375, Bioorganic & Medicinal Chemistry Letters, 1998, Leon, Susanna; Quarrell, Rachel; Lowe, Gordon
Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.
score: 1.3027766, Antimicrobial agents and chemotherapy, 2002, Uckun, Fatih M et. al.
3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion
score: 1.3027561, Bioorganic & Medicinal Chemistry Letters, 2000, Girlanda-Junges, Céline et. al.
Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations.
score: 1.3027205, Antimicrobial agents and chemotherapy, 2005, Morgan, Sheila M et. al.
Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation
score: 1.3026444, Bioorganic & Medicinal Chemistry Letters, 2012, Volkova, Maria S. et. al.
LNA guanine and 2,6-diaminopurine. Synthesis, characterization and hybridization properties of LNA 2,6-diaminopurine containing oligonucleotides
score: 1.3025348, Bioorganic & Medicinal Chemistry, 2004, Rosenbohm, Christoph et. al.
Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.
score: 1.3023413, Antimicrobial agents and chemotherapy, 2004, Mendes, Rodrigo E et. al.
The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP.
score: 1.3021924, Antimicrobial agents and chemotherapy, 2012, Barrera, Borja et. al.
Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212
score: 1.3021242, Bioorganic & Medicinal Chemistry, 2003, Biava, Mariangela et. al.
Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus.
score: 1.3020579, Antimicrobial agents and chemotherapy, 2001, Delaney, W E et. al.
Quantitative structure–activity relationship to predict differential inhibition of aldose reductase by flavonoid compounds
score: 1.3020281, Bioorganic & Medicinal Chemistry, 2005, Fernández, Michael et. al.
In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.
score: 1.3020071, Antimicrobial agents and chemotherapy, 2011, Zhou, Nannan et. al.
Synthesis and microtubule binding of fluorescent paclitaxel derivatives
score: 1.3019809, Bioorganic & Medicinal Chemistry Letters, 2001, Baloglu, Erkan et. al.
Synthesis, Biological Activity, and Conformational Studies of Insect Allatostatin Neuropeptide Analogues Incorporating Turn-Promoting Moieties 1 Dedicated to Professor Stuart Schreiber on the occasion of his award of the Tetrahedron Prize. 1
score: 1.3018255, Bioorganic & Medicinal Chemistry, 1998, Nachman, Ronald J et. al.
Synthesis of DNA analogues with novel carboxamidomethyl phosphonamide and glycinamide internucleoside linkages
score: 1.3018191, Bioorganic & Medicinal Chemistry Letters, 1998, Efimov, V.A.; Buryakova, A.A.; Chakhmakhcheva, O.G.
Mixture-based heterocyclic combinatorial positional scanning libraries: discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans.
score: 1.3018129, Antimicrobial agents and chemotherapy, 1999, Blondelle, S E; Crooks, E; Ostresh, J M; Houghten, R A
Synthesis of novel 9-O-N-aryl/aryl–alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects
score: 1.3016644, Bioorganic & Medicinal Chemistry, 2012, Basu, Anirban et. al.
Discrimination between ribonuclease H- and ribonuclease L-mediated RNA degradation by 2′- O-methylated 2-5A-antisense oligonucleotides
score: 1.3016133, Bioorganic & Medicinal Chemistry Letters, 1999, Cramer, Hagen; Player, Mark R.; Torrence, Paul F.
Towards biomarker-dependent individualized chemotherapy: Exploring cell-specific differences in oxaliplatin–DNA adduct distribution using accelerator mass spectrometry
score: 1.3015536, Bioorganic & Medicinal Chemistry Letters, 2010, Hah, Sang Soo; Henderson, Paul T.; Turteltaub, Kenneth W.
Label-free fluorescent real-time monitoring of adenylyl cyclase
score: 1.3013091, Bioorganic & Medicinal Chemistry Letters, 2010, Rhee, Hyun-Woo et. al.
Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in taiwan.
score: 1.3012996, Antimicrobial agents and chemotherapy, 2011, Lin, Yi-Chun et. al.
Screen for inhibitors of the coupled transglycosylase-transpeptidase of peptidoglycan biosynthesis in Escherichia coli.
score: 1.3012698, Antimicrobial agents and chemotherapy, 2006, Ramachandran, Vasanthi et. al.
Versatile synthesis and biological evaluation of 1,3-diamino-substituted 1α,25-dihydroxyvitamin D 3 analogues
score: 1.3012417, Bioorganic & Medicinal Chemistry, 2006, Oves, Daniel et. al.
Daptomycin bactericidal activity and correlation between disk and broth microdilution method results in testing of Staphylococcus aureus strains with decreased susceptibility to vancomycin.
score: 1.3010988, Antimicrobial agents and chemotherapy, 2006, Sader, Helio S; Fritsche, Thomas R; Jones, Ronald N
Synthesis of a technetium-99m labeled tricyclic ganciclovir analog for non-invasive reporter gene expression imaging
score: 1.3010743, Bioorganic & Medicinal Chemistry Letters, 2007, Zhang, Yi; Lin, Jing; Pan, Dongfeng
Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution
score: 1.3010692, Bioorganic & Medicinal Chemistry Letters, 2006, Polidori, Ange et. al.
The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: rational modifications imparting PP1 selectivity
score: 1.3010199, Bioorganic & Medicinal Chemistry, 1999, Aggen, James B et. al.
Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens.
score: 1.3008691, Antimicrobial agents and chemotherapy, 2002, Farrow, Kylie A et. al.
ω-(Imidazol-4-yl)alkane-1-sulfonamides: a new series of potent histamine H 3 receptor antagonists
score: 1.3006819, Bioorganic & Medicinal Chemistry, 2002, Tozer, Matthew J. et. al.
Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt
score: 1.3005889, Bioorganic & Medicinal Chemistry Letters, 2008, Risbood, Prabhakar A. et. al.
Synthesis of oxorhenium(V) and oxotechnetium(V) [SN(R)S/S] mixed ligand complexes containing a phenothiazine moiety on the tridentate SN(R)S ligand
score: 1.3005738, Bioorganic & Medicinal Chemistry Letters, 2001, Pirmettis, Ioannis et. al.
The synthesis and in vitro antibacterial activity of conformationally restricted quinolone antibacterial agents
score: 1.3005244, Bioorganic & Medicinal Chemistry, 1996, Cooper, Curt S. et. al.
Delivering a hydrophobic anticancer drug for photodynamic therapy by amorphous formulation
score: 1.3005088, Bioorganic & Medicinal Chemistry Letters, 2010, Zhou, Lin et. al.
Comparison of three γ-turn mimetic scaffolds incorporated into angiotensin II
score: 1.3003989, Bioorganic & Medicinal Chemistry, 2000, Lindman, Susanna et. al.
Synthesis and structure-activity relationships of cephalosporins, 2-isocephems, and 2-oxaisocephems with C-3′ or C-7 catechol or related aromatics
score: 1.3003613, Bioorganic & Medicinal Chemistry, 1996, Tsuji, Koichi et. al.
Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs.
score: 1.3003528, Antimicrobial agents and chemotherapy, 2007, Nikonenko, Boris V et. al.
5-Substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase
score: 1.3001935, Bioorganic & Medicinal Chemistry Letters, 1999, Wouters, Johan; Herdewijn, Piet
Fungal cell wall septation and cytokinesis are inhibited by bleomycins.
score: 1.3001916, Antimicrobial agents and chemotherapy, 2003, Moore, Carol W et. al.
Synthesis and antimicrobial evaluation of new 2-substituted 5,7-di- tert-butylbenzoxazoles
score: 1.3001053, Bioorganic & Medicinal Chemistry, 2006, Vinsova, Jarmila et. al.
Membrane-Permeant derivatives of mannose-1-phosphate
score: 1.3001038, Bioorganic & Medicinal Chemistry, 2002, Rutschow, Synke et. al.
Atom, atom-type, and total nonstochastic and stochastic quadratic fingerprints: a promising approach for modeling of antibacterial activity
score: 1.2999957, Bioorganic & Medicinal Chemistry, 2005, Marrero-Ponce, Yovani et. al.
Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives
score: 1.299966, European Journal of Medicinal Chemistry, 2012, Garudachari, B. et. al.
Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes.
score: 1.2998491, Antimicrobial agents and chemotherapy, 2004, Bonnet, R
Noninvasive Determination of 2-[18F]-Fluoroisonicotinic Acid Hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis-Infected Mice.
score: 1.2998036, Antimicrobial agents and chemotherapy, 2012, Weinstein, E A et. al.
Hepatoprotective constituents from Zedoariae Rhizoma: absolute stereostructures of three new carabrane-type sesquiterpenes, curcumenolactones A, B, and C
score: 1.2997854, Bioorganic & Medicinal Chemistry, 2001, Matsuda, Hisashi et. al.
Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227).
score: 1.299651, Antimicrobial agents and chemotherapy, 2008, Seiwert, Scott D et. al.
Lead development: Validation and application of high throughput screening for determination of pharmacokinetic parameters for enzyme inhibitors
score: 1.299636, Bioorganic & Medicinal Chemistry, 1996, Singh, Jasbir et. al.
Ab initio calculations on ( Z)-5-decenyl acetate, a component of the pheromone complex of Agrotis segetum (Lepidoptera: Noctuidae) and electrophysiological studies with chain elongated analogues
score: 1.2995404, Bioorganic & Medicinal Chemistry, 1996, Bestmann, Hans Jürgen et. al.
In vitro and in vivo properties of BAL30376, a β-lactam and dual beta-lactamase inhibitor combination with enhanced activity against Gram-negative Bacilli that express multiple β-lactamases.
score: 1.2994208, Antimicrobial agents and chemotherapy, 2011, Page, Malcolm G P et. al.
Synthesis of a polymeric 4- N-linked sialoside which inhibits influenza virus hemagglutinin
score: 1.2993817, Bioorganic & Medicinal Chemistry Letters, 2000, Wu, Wen-Yang; Jin, Betty; Krippner, Guy Y.; Watson, Keith G.
Aromatic carboxylic acids as farnesyl surrogates in farnesylpyrophosphate-based farnesyltransferase inhibitors
score: 1.2992226, Bioorganic & Medicinal Chemistry, 1999, Schlitzer, Martin; Sattler, Isabel
Synthesis of novel pyrrolyl-indomethacin derivatives
score: 1.2992042, European Journal of Medicinal Chemistry, 2012, Serra Moreno, Judith et. al.
Synthesis of novel pyrrolyl-indomethacin derivatives
score: 1.2992042, European Journal of Medicinal Chemistry, 2012, Serra Moreno, Judith et. al.
Synthesis of β-( S-methyl)thioaspartic acid and derivatives
score: 1.2991074, Bioorganic & Medicinal Chemistry, 2008, Heredia-Moya, Jorge; Kirk, Kenneth L.
Inhibiting protein–amyloid interactions with small molecules: A surface chemistry approach
score: 1.2989828, Bioorganic & Medicinal Chemistry Letters, 2006, Inbar, Petra; Yang, Jerry
New cluster of plasmid-located class 1 integrons in Vibrio cholerae O1 and a dfrA15 cassette-containing integron in Vibrio parahaemolyticus isolated in Angola.
score: 1.2988913, Antimicrobial agents and chemotherapy, 2006, Ceccarelli, Daniela et. al.
Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.
score: 1.2988431, Antimicrobial agents and chemotherapy, 2004, North, Thomas W et. al.
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/ oxadiazole ring
score: 1.2988237, European Journal of Medicinal Chemistry, 2012, Mohammed Iqbal, A. K et. al.
Induction of fibronectin adhesins in quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin or by sigma B transcription factor activity is mediated by two separate pathways.
score: 1.2986743, Antimicrobial agents and chemotherapy, 2005, Li, Dongmei et. al.
Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates.
score: 1.2985099, Antimicrobial agents and chemotherapy, 2000, Meyer, P R et. al.
Design of peptidomimetic ligands for the pp60 src SH2 domain
score: 1.298299, Bioorganic & Medicinal Chemistry, 1997, Plummer, Mark S. et. al.
Antimelanomal activity of the copper(II) complexes of 1-substituted 5-amino-imidazole ligands against B16F10 mouse melanoma cells
score: 1.2982724, Bioorganic & Medicinal Chemistry Letters, 2004, Sandbhor, Uday et. al.
First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin
score: 1.2981162, Bioorganic & Medicinal Chemistry, 2000, Couture, Axel et. al.
Pharmacodynamics of vancomycin at simulated epithelial lining fluid concentrations against methicillin-resistant Staphylococcus aureus (MRSA): implications for dosing in MRSA pneumonia.
score: 1.2981023, Antimicrobial agents and chemotherapy, 2009, Harigaya, Yoriko et. al.
Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors
score: 1.2979827, Bioorganic & Medicinal Chemistry, 2006, Litzinger, Elizabeth A. et. al.
Synthesis of 6″-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands
score: 1.2977291, Bioorganic & Medicinal Chemistry, 2012, Pauwels, Nora et. al.
Synthesis of 6′′-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands
score: 1.2977291, Bioorganic & Medicinal Chemistry, 2012, Pauwels, Nora et. al.
Synthesis of 6″-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands
score: 1.2977291, Bioorganic & Medicinal Chemistry, 2012, Pauwels, Nora et. al.
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors
score: 1.2975579, Bioorganic & Medicinal Chemistry, 2012, He, Yantao et. al.
3-Carboxy-20-keto steroids are dual uncompetitive inhibitors of human steroid 5α-reductase types 1 and 2
score: 1.2975249, Bioorganic & Medicinal Chemistry, 1996, Yamashita, Dennis S. et. al.
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.
score: 1.2974753, Antimicrobial agents and chemotherapy, 2005, McAleese, Fionnuala et. al.
Annelated pyrrolo-pyrimidines from amino-cyanopyrroles and BMMAs as leads for new DNA-interactive ring systems
score: 1.297369, Bioorganic & Medicinal Chemistry, 2005, Lauria, Antonino et. al.
JNJ-Q2, a new fluoroquinolone with potent in vitro activity against Staphylococcus aureus, including methicillin- and fluoroquinolone-resistant strains.
score: 1.2973406, Antimicrobial agents and chemotherapy, 2011, Farrell, David J et. al.
Radial distribution function descriptors: an alternative for predicting A 2 A adenosine receptors agonists
score: 1.2973032, European Journal of Medicinal Chemistry, 2006, González, Maykel Pérez et. al.
Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin
score: 1.2972596, Bioorganic & Medicinal Chemistry, 2005, McGuigan, Christopher et. al.
The influence of substitution at aromatic part of 1,2,3,4-tetrahydroisoquinoline on in vitro and in vivo 5-HT 1A/5-HT 2A receptor activities of its 1-adamantoyloaminoalkyl derivatives
score: 1.2972487, Bioorganic & Medicinal Chemistry, 2002, Bojarski, Andrzej J et. al.
Antimicrobial characterization of human beta-defensin 3 derivatives.
score: 1.2971871, Antimicrobial agents and chemotherapy, 2003, Hoover, David M et. al.
Dicaffeoyl- or digalloyl pyrrolidine and furan derivatives as HIV integrase inhibitors
score: 1.2969913, Bioorganic & Medicinal Chemistry, 2001, Hwang, Dong Jin et. al.
Syntheses and antimicrobial activities of a series of new bis-quaternary ammonium compounds
score: 1.2969112, European Journal of Medicinal Chemistry, 2006, Kourai, Hiroki et. al.
C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I
score: 1.2969045, Bioorganic & Medicinal Chemistry Letters, 2008, Wang, Yifan et. al.
OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.
score: 1.2968129, Antimicrobial agents and chemotherapy, 2005, Poirel, Laurent et. al.
Synthesis and evaluation of the antioxidant and antiinflammatory activities of some benzo[l]khellactone derivatives and analogues
score: 1.2968016, European Journal of Medicinal Chemistry, 2004, Nicolaides, Demetrios N et. al.
Syntheses and preliminary biological studies of four meso-Tetra[( nido-carboranylmethyl)phenyl]porphyrins
score: 1.2967975, Bioorganic & Medicinal Chemistry, 2002, Vicente, M.Graça H. et. al.
Evaluation of DNA binding, antioxidant and cytotoxic activity of mononuclear Co(III) complexes of 2-oxo-1,2-dihydrobenzo[h]quinoline-3-carbaldehyde thiosemicarbazones
score: 1.2967605, European Journal of Medicinal Chemistry, 2012, Ramachandran, Eswaran et. al.
Synthesis, characterization and in vitro Antiamoebic Activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones and their Palladium (II) and Ruthenium (II) Complexes
score: 1.2967066, European Journal of Medicinal Chemistry, 2004, Singh, Shailendra et. al.
3- N, N-Dimethylamino-3-deoxy lincomycin: A structure-based hybrid between lincomycin and the desosamine unit of erythromycin
score: 1.2966236, Bioorganic & Medicinal Chemistry, 2005, Hanessian, Stephen; Kothakonda, Kiran Kumar
pH sensing in living cells using fluorescent microspheres
score: 1.2963218, Bioorganic & Medicinal Chemistry Letters, 2008, Bradley, Mark et. al.
Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.
score: 1.2962965, Antimicrobial agents and chemotherapy, 2002, Borowski, Peter et. al.
Synthesis and antitumour activity of new muricatacin and goniofufurone analogues
score: 1.296226, European Journal of Medicinal Chemistry, 2006, Popsavin, Velimir et. al.
In vitro and In vivo activities of LB 10827, a new oral cephalosporin, against respiratory pathogens.
score: 1.2961828, Antimicrobial agents and chemotherapy, 2000, Paek, K S; Kim, M Y; Lee, C S; Youn, H
Activity of ertapenem (MK-0826) versus Enterobacteriaceae with potent beta-lactamases.
score: 1.2961004, Antimicrobial agents and chemotherapy, 2001, Livermore, D M; Oakton, K J; Carter, M W; Warner, M
Trypanocidal and leishmanicidal properties of substitution-containing chalcones.
score: 1.2960879, Antimicrobial agents and chemotherapy, 2003, Lunardi, Fabiane et. al.
Protease-mediated enzymatic hydrolysis and activation of aryl phosphoramidate derivatives of stavudine
score: 1.2958835, European Journal of Medicinal Chemistry, 2005, Venkatachalam, T.K.; Samuel, P.; Qazi, S.; Uckun, F.M.
Synthesis of poly(maleimide-co-2-ethylacrylic acid) and its properties of suppressing metastasis and growth of carcinoma
score: 1.2958351, Bioorganic & Medicinal Chemistry Letters, 2002, Zhu, Zhongliang; Shi, Lianjun; Huang, Junlian
Synthesis and biological evaluations of C-23-modified 26,26,26,27,27,27-F 6-vitamin D 3 analogues
score: 1.2957696, Bioorganic & Medicinal Chemistry, 2000, Ikeda, Masahiko et. al.
Anthranilic acid based CCK 1 receptor antagonists: preliminary investigation on their second “touch point”
score: 1.2957636, European Journal of Medicinal Chemistry, 2005, Varnavas, Antonio et. al.
Synthesis of the cyclic and acyclic acetal derivatives of 1-(3- C-Ethynyl-β- d- ribo-pentofuranosyl)cytosine, a potent antitumor nucleoside. Design of prodrugs to be selectively activated in tumor tissues via the bio-Reduction–Hydrolysis mechanism
score: 1.2957499, Bioorganic & Medicinal Chemistry, 2003, Nomura, Makoto; Shuto, Satoshi; Matsuda, Akira
Genetic incorporation of an aliphatic keto-containing amino acid into proteins for their site-specific modifications
score: 1.2956624, Bioorganic & Medicinal Chemistry Letters, 2010, Huang, Ying et. al.
Potential tuberculostatic agents. Topliss application on benzoic acid [(5-Nitro-thiophen-2-yl)-methylene]-hydrazide series
score: 1.2955053, Bioorganic & Medicinal Chemistry, 2002, Rando, Daniela G et. al.
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases
score: 1.295471, Bioorganic & Medicinal Chemistry Letters, 2004, van Swieten, Paul F. et. al.
Hydroxyacyl derivatives of forskolin—their positive inotropic activity
score: 1.2954324, Bioorganic & Medicinal Chemistry, 1998, Lal, Bansi et. al.
Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in treatment and prevention of experimental invasive pulmonary aspergillosis: correlation with galactomannan antigenemia.
score: 1.2954053, Antimicrobial agents and chemotherapy, 2001, Petraitiene, R et. al.
QSAR modeling of anti-invasive activity of organic compounds using structural descriptors
score: 1.2953716, Bioorganic & Medicinal Chemistry, 2006, Katritzky, Alan R. et. al.
An automated image-based method for rapid analysis of Chlamydia infection as a tool for screening antichlamydial agents.
score: 1.2952492, Antimicrobial agents and chemotherapy, 2012, Osaka, Ichie et. al.
Photochemical control of FlAsH labeling of proteins
score: 1.2952208, Bioorganic & Medicinal Chemistry Letters, 2009, Wilkins, Bryan J.; Yang, Xu; Cropp, T. Ashton
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone.
score: 1.2952179, Antimicrobial agents and chemotherapy, 2002, Ince, Dilek et. al.
Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug
score: 1.2951871, Bioorganic & Medicinal Chemistry, 2003, Chung, Man-Chin et. al.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
score: 1.2950611, Nature chemical biology, 2011, Vedadi, Masoud et. al.
Microbial transformation of (−)-isolongifolol and butyrylcholinesterase inhibitory activity of transformed products
score: 1.2949326, Bioorganic & Medicinal Chemistry, 2005, Choudhary, M. Iqbal et. al.
Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to α-ketoamide inhibitors
score: 1.2948487, European Journal of Medicinal Chemistry, 2003, Bruton, Gordon et. al.
Antiherpesvirus activities of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine (A-5021) in cell culture.
score: 1.2946838, Antimicrobial agents and chemotherapy, 1998, Iwayama, S et. al.
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties
score: 1.2946164, Bioorganic & Medicinal Chemistry, 2004, Kupchinsky, Stanley et. al.
Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12
score: 1.2945501, Bioorganic & Medicinal Chemistry, 2006, Holas, Tomáš et. al.
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease
score: 1.2944221, Bioorganic & Medicinal Chemistry Letters, 2013, Li, Hongmei et. al.
Synthesis of a pentasaccharide corresponding to the repeating unit of the exopolysaccharide from cryptococcus neoformans serovar D
score: 1.294399, Bioorganic & Medicinal Chemistry, 1996, Zegelaar-Jaarsveld, Korien et. al.
DNA-binding peptides searched from the solid-phase combinatorial library with the use of the magnetic beads attaching the target duplex DNA
score: 1.2943936, Bioorganic & Medicinal Chemistry, 2000, Rowshon Alam, Md; Maeda, Minoru; Sasaki, Shigeki
Synthesis and in vitro analysis of atrial natriuretic peptide–albumin conjugates
score: 1.2941441, Bioorganic & Medicinal Chemistry Letters, 2003, Léger, Roger et. al.
Antimicrobial and anticoagulant activities of N-chlorotaurine, N,N-dichloro-2,2-dimethyltaurine, and N-monochloro-2,2-dimethyltaurine in human blood.
score: 1.2941424, Antimicrobial agents and chemotherapy, 2012, Martini, C et. al.
Designed potent multivalent chemoattractants for Escherichia coli
score: 1.2941226, Bioorganic & Medicinal Chemistry, 2001, Gestwicki, Jason E. et. al.
Carbonic anhydrase inhibitors: Inhibition of human and murine mitochondrial isozymes V with anions
score: 1.2940864, Bioorganic & Medicinal Chemistry Letters, 2003, Franchi, Marco et. al.
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.
score: 1.2939639, Antimicrobial agents and chemotherapy, 1998, Mungthin, M; Bray, P G; Ridley, R G; Ward, S A
Studies on the trypanocidal activity of semi-synthetic pyran[ b-4,3]naphtho[1,2- d]imidazoles from β-lapachone
score: 1.2938973, European Journal of Medicinal Chemistry, 2004, De Moura, Kelly C.G et. al.
A molecular modeling analysis of the binding interactions between the okadaic acid class of natural product inhibitors and the ser-thr phosphatases, PP1 and PP2A
score: 1.2938653, Bioorganic & Medicinal Chemistry, 1997, Gauss, Carla-Maria et. al.
Synthesis and biological evaluation of 99mTc(CO)3(His–CB) as a tumor imaging agent
score: 1.2938619, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Jianjun et. al.
Synthesis and biological evaluation of 99mTc(CO)3(His–CB) as a tumor imaging agent
score: 1.2938619, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Jianjun et. al.
Synthesis and biological evaluation of 99mTc(CO)3(His–CB) as a tumor imaging agent
score: 1.2938619, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Jianjun et. al.
Mechanisms mediating bactericidal properties and conditions that enhance the potency of a broad-spectrum oligo-acyl-lysyl.
score: 1.29382, Antimicrobial agents and chemotherapy, 2011, Sarig, Hadar; Goldfeder, Yair; Rotem, Shahar; Mor, Amram
In vitro activities of aminomethyl-substituted analogs of novel tetrahydrofuranyl carbapenems.
score: 1.2937771, Antimicrobial agents and chemotherapy, 1999, Weiss, W J et. al.
Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs
score: 1.2935376, European Journal of Medicinal Chemistry, 2010, Ouyang, Liang et. al.
Macrolide-resistant Streptococcus pneumoniae in Canada during 1998-1999: prevalence of mef(A) and erm(B) and susceptibilities to ketolides.
score: 1.293462, Antimicrobial agents and chemotherapy, 2001, Hoban, D J; Wierzbowski, A K; Nichol, K; Zhanel, G G
Cytotoxic activities of water-soluble chitosan derivatives with different degree of deacetylation
score: 1.2927261, Bioorganic & Medicinal Chemistry Letters, 2006, Je, Jae-Young; Cho, Young-Sook; Kim, Se-Kwon
Modelling, synthesis and biological evaluation of an ethidium–arginine conjugate linked to a ribonuclease mimic directed against TAR RNA of HIV-1
score: 1.2926382, European Journal of Medicinal Chemistry, 2002, Patino, Nadia et. al.
Inhibitory effects of metachromins L–Q and its related analogs against receptor tyrosine kinases EGFR and HER2
score: 1.2924946, Bioorganic & Medicinal Chemistry Letters, 2013, Takahashi, Yohei et. al.
Novel compounds active against Leishmania major.
score: 1.2921728, Antimicrobial agents and chemotherapy, 2006, St George, Stephanie et. al.
QSAR prediction of toxicity of nitrobenzenes
score: 1.2921418, Bioorganic & Medicinal Chemistry, 2001, Agrawal, V.K.; Khadikar, P.V.
QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors
score: 1.2920729, European Journal of Medicinal Chemistry, 2010, Ravichandran, Veerasamy et. al.
QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors
score: 1.2920729, European Journal of Medicinal Chemistry, 2010, Ravichandran, Veerasamy et. al.
Oncoepigenomics: Making histone lysine methylation count
score: 1.2916869, European Journal of Medicinal Chemistry, 2012, DeCarlo, Daniel; Hadden, M. Kyle
Oncoepigenomics: Making histone lysine methylation count
score: 1.2916869, European Journal of Medicinal Chemistry, 2012, DeCarlo, Daniel; Hadden, M. Kyle
Synthesis of pyrrolo[2,1- c][1,4]benzodiazepines and their conjugates by azido reductive cyclization strategy as potential DNA-binding agents
score: 1.2916182, Bioorganic & Medicinal Chemistry Letters, 2005, Kamal, Ahmed et. al.
Oligonucleotides tethered to a short polyguanylic acid stretch are targeted to macrophages: enhanced antiviral activity of a vesicular stomatitis virus-specific antisense oligonucleotide.
score: 1.2915086, Antimicrobial agents and chemotherapy, 1999, Prasad, V; Hashim, S; Mukhopadhyay, A; Basu, S K; Roy, R P
UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): Promising step in prediction of oligonucleotide analog properties?
score: 1.2913764, Bioorganic & Medicinal Chemistry Letters, 1998, Pressová, Martina et. al.
Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA.
score: 1.2913544, Antimicrobial agents and chemotherapy, 2006, Leung, E T Y et. al.
Chemoenzymatic synthesis of CD52 glycoproteins carrying native N-glycans
score: 1.2913108, Bioorganic & Medicinal Chemistry Letters, 2005, Li, Hengguang et. al.
Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr 5,12, Lys 7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection
score: 1.2912914, Bioorganic & Medicinal Chemistry, 1998, Tamamura, Hirokazu et. al.
Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation
score: 1.2911995, Bioorganic & Medicinal Chemistry, 2004, Gorczynski, Michael J. et. al.
Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes.
score: 1.2911203, Antimicrobial agents and chemotherapy, 2004, Paris, Caroline et. al.
Molecular determinants of non-specific recognition of δ, μ, and κ opioid receptors
score: 1.2911167, Bioorganic & Medicinal Chemistry, 2001, Filizola, Marta; Villar, Hugo O; Loew, Gilda H
Synthetic mannosides act as acceptors for mycobacterial α1-6 mannosyltransferase
score: 1.2910723, Bioorganic & Medicinal Chemistry, 2001, Brown, Jillian R et. al.
A new route to trihydroxamate-containing artificial siderophores and synthesis of a new fluorescent probe
score: 1.2909227, Bioorganic & Medicinal Chemistry, 2005, Ouchetto, H. et. al.
Peptide binding to the HLA-DRB1 supertype: A proteochemometrics analysis
score: 1.2908379, European Journal of Medicinal Chemistry, 2010, Dimitrov, Ivan et. al.
Synthesis and cytotoxicity of 6,11-Dihydro-pyrido- and 6,11-Dihydro-benzo[2,3- b]phenazine-6,11-dione derivatives
score: 1.290825, Bioorganic & Medicinal Chemistry, 2003, Kim, Young-Shin et. al.
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues
score: 1.2908167, Bioorganic & Medicinal Chemistry, 2012, Mostert, Samantha et. al.
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues
score: 1.2908167, Bioorganic & Medicinal Chemistry, 2012, Mostert, Samantha et. al.
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues
score: 1.2908167, Bioorganic & Medicinal Chemistry, 2012, Mostert, Samantha et. al.
Gametocytocidal activity and synergistic interactions of riboflavin with standard antimalarial drugs against growth of Plasmodium falciparum in vitro.
score: 1.2906019, Antimicrobial agents and chemotherapy, 2000, Akompong, T; Eksi, S; Williamson, K; Haldar, K
Preparation of a protected phosphoramidon precursor via an H-Phosphonate coupling strategy
score: 1.2905018, Bioorganic & Medicinal Chemistry Letters, 2006, Donahue, Matthew G.; Johnston, Jeffrey N.
Synthesis, antimicrobial activity and conformational analysis of novel substituted pyridines: BF 3-promoted reaction of hydrazine with 2-alkoxy pyridines
score: 1.2904171, Bioorganic & Medicinal Chemistry, 2004, Goda, Fatma E.; Abdel-Aziz, Alaa A.-M.; Attef, Omer A.
Bivalent peptides as PDZ domain ligands
score: 1.2902804, Bioorganic & Medicinal Chemistry Letters, 2007, Klosi, Edvin; Saro, Dorina; Spaller, Mark R.
Inactivation of medium-chain acyl-CoA dehydrogenase by oct-4-en-2-ynoyl-CoA
score: 1.2901708, Bioorganic & Medicinal Chemistry Letters, 2006, Zeng, Jia; Deng, Guisheng; Yu, Wenhua; Li, Ding
Carbapenems: past, present, and future.
score: 1.2901221, Antimicrobial agents and chemotherapy, 2011, Papp-Wallace, Krisztina M et. al.
Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States.
score: 1.2900941, Antimicrobial agents and chemotherapy, 2004, Wang, Minggui et. al.
Preparation of carbohydrate–oligonucleotide conjugates using the squarate spacer
score: 1.2900482, Bioorganic & Medicinal Chemistry Letters, 2007, Yan, Hongbin; Aguilar, Aimé López; Zhao, Yuyan
Sesquiterpenoids from Atractylodes macrocephala act as farnesoid X receptor and progesterone receptor modulators
score: 1.2900377, Bioorganic & Medicinal Chemistry Letters, 2012, Tsai, Chia-Jui; Liang, Jui-Wei; Lin, Hsiang-Ru
Deconvolution by omission libraries
score: 1.2900273, Bioorganic & Medicinal Chemistry Letters, 1998, Câmpian, Eugen et. al.
A synthetic congener modeled on a microbicidal domain of thrombin- induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native molecule.
score: 1.2899719, Antimicrobial agents and chemotherapy, 2006, Xiong, Yan Q et. al.
Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation.
score: 1.2898034, Antimicrobial agents and chemotherapy, 2004, Equils, Ozlem et. al.
New pH-dependent complexes, from mononuclear Pd(II) monomer to heteronuclear [Pd(II),K(I)]Polymer: DNA cleavage and cytotoxicity in vitro
score: 1.2896438, European Journal of Medicinal Chemistry, 2010, Gao, En-Jun et. al.
In vitro activity of cephalosporin RWJ-54428 (MC-02479) against multidrug-resistant gram-positive cocci.
score: 1.2896349, Antimicrobial agents and chemotherapy, 2002, Johnson, Alan P et. al.
Carbonic anhydrase inhibitors: Inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides
score: 1.2895157, Bioorganic & Medicinal Chemistry, 2005, Özensoy, Özen et. al.
In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine.
score: 1.289348, Antimicrobial agents and chemotherapy, 2011, van Belkum, Alex; Fahal, Ahmed H; van de Sande, Wendy W J
[18F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
score: 1.2891873, Bioorganic & Medicinal Chemistry, 2012, Philippe, Cécile et. al.
Synthesis of β-hydroxy-α-amino acids with a reengineered alanine racemase
score: 1.2889848, Bioorganic & Medicinal Chemistry Letters, 2008, Fesko, Kateryna; Giger, Lars; Hilvert, Donald
KPC-9, a Novel Carbapenemase from Clinical Specimens in Israel.
score: 1.2887258, Antimicrobial agents and chemotherapy, 2012, Hidalgo-Grass, Carlos et. al.
Morita–Baylis–Hillman adducts: Biological activities and potentialities to the discovery of new cheaper drugs
score: 1.2886842, Bioorganic & Medicinal Chemistry, 2012, Lima–Junior, Claudio G.; Vasconcellos, Mário L.A.A.
Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid
score: 1.288673, Bioorganic & Medicinal Chemistry Letters, 2004, Xu, Yong; Fang, Yimin; Chen, Jie; Prestwich, Glenn D.
Synthesis and in vitro antitumor evaluation of some indeno[1,2- c]pyrazol(in)es substituted with sulfonamide, sulfonylurea(-thiourea) pharmacophores, and some derived thiazole ring systems
score: 1.2886363, Bioorganic & Medicinal Chemistry, 2006, Rostom, Sherif A.F.
Synthesis and evaluation of a conformationally constrained pyridazinone PNA-monomer for recognition of thymine in triple-helix structures
score: 1.2886202, Bioorganic & Medicinal Chemistry Letters, 2004, Olsen, Anne Goldbech; Dahl, Otto; Nielsen, Peter E.
Noncovalent inhibition of 20S proteasome by pegylated dimerized inhibitors
score: 1.2884685, European Journal of Medicinal Chemistry, 2012, Maréchal, Xavier et. al.
Abscinazole-E2B, a practical and selective inhibitor of ABA 8’-hydroxylase CYP707A
score: 1.2884615, Bioorganic & Medicinal Chemistry, 2012, Okazaki, Mariko et. al.
Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites.
score: 1.2883812, Antimicrobial agents and chemotherapy, 2011, Beez, Dorothee et. al.
On the role of polarizability in QSAR
score: 1.2883568, Bioorganic & Medicinal Chemistry, 2005, Verma, Rajeshwar P.; Kurup, Alka; Hansch, Corwin
Synthesis and evaluation of nitro 5-deazaflavin-pyrrolecarboxamide(s) hybrid molecules as novel DNA targeted bioreductive antitumor agents
score: 1.2882616, Bioorganic & Medicinal Chemistry, 1998, Kanaoka, Yoshitomo et. al.
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management
score: 1.2882535, Bioorganic & Medicinal Chemistry Letters, 2012, Nelson, Derek W. et. al.
Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime.
score: 1.2881974, Antimicrobial agents and chemotherapy, 2002, Vakulenko, Sergei B et. al.
In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor
score: 1.2880493, Bioorganic & Medicinal Chemistry, 2005, Li, Jin et. al.
Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification
score: 1.287963, Bioorganic & Medicinal Chemistry Letters, 2010, de Barros, André Luís Branco et. al.
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters
score: 1.2879147, Bioorganic & Medicinal Chemistry Letters, 2012, Trujillo, John I. et. al.
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters
score: 1.2879147, Bioorganic & Medicinal Chemistry Letters, 2012, Trujillo, John I. et. al.
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters
score: 1.2879147, Bioorganic & Medicinal Chemistry Letters, 2012, Trujillo, John I. et. al.
Topological models for the prediction of anti-HIV activity of dihydro (alkylthio) (naphthylmethyl) oxopyrimidines
score: 1.287863, Bioorganic & Medicinal Chemistry, 2005, Lather, Viney; Madan, A.K.
Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
score: 1.2878301, Bioorganic & Medicinal Chemistry, 2012, Kamal, Ahmed et. al.
Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species
score: 1.2877905, Bioorganic & Medicinal Chemistry Letters, 2010, Ott, Ingo et. al.
Molecular characterization of extended-spectrum-β-lactamase-producing and plasmid-mediated AmpC β-lactamase-producing Escherichia coli isolated from stray dogs in South Korea.
score: 1.2877513, Antimicrobial agents and chemotherapy, 2012, Tamang, Migma Dorji et. al.
Novel imidazolyl and triazolyl substituted biphenyl compounds: synthesis and evaluation as nonsteroidal inhibitors of human 17α-hydroxylase-C17, 20-Lyase (P450 17)
score: 1.2876289, Bioorganic & Medicinal Chemistry, 2000, Zhuang, Yan; Wachall, Bertil G.; Hartmann, Rolf W.
New Method of Synthesis of Vinca Alkaloid Derivatives
score: 1.2875728, Bioorganic & Medicinal Chemistry Letters, 2002, Fahy, Jacques et. al.
An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli
score: 1.2875354, Bioorganic & Medicinal Chemistry, 2012, Blažek, Jiří et. al.
An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli
score: 1.2875354, Bioorganic & Medicinal Chemistry, 2012, Blažek, Jiří et. al.
In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae.
score: 1.2875322, Antimicrobial agents and chemotherapy, 2000, Strigl, S; Roblin, P M; Reznik, T; Hammerschlag, M R
Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities
score: 1.2874891, European Journal of Medicinal Chemistry, 2012, Sipos, Attila et. al.
Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities
score: 1.2874891, European Journal of Medicinal Chemistry, 2012, Sipos, Attila et. al.
Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents
score: 1.2873423, European Journal of Medicinal Chemistry, 2001, Madhavan, Gurram R et. al.
Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study
score: 1.2870826, Bioorganic & Medicinal Chemistry Letters, 2004, Yadav, Vikas; Chu, Chung K
Biofilm formation by the emerging fungal pathogen Trichosporon asahii: development, architecture, and antifungal resistance.
score: 1.2870803, Antimicrobial agents and chemotherapy, 2006, Di Bonaventura, Giovanni et. al.
Kinetic and Crystallographic Studies of Extended-Spectrum GES-11, GES-12, and GES-14 β-Lactamases.
score: 1.2869903, Antimicrobial agents and chemotherapy, 2012, Delbrück, Heinrich et. al.
‘Irreversible’ slow-onset inhibition of orotate phosphoribosyltransferase by an amidrazone phosphate transition-state mimic
score: 1.2869078, Bioorganic & Medicinal Chemistry Letters, 2006, Witte, John F. et. al.
Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis.
score: 1.2868835, Antimicrobial agents and chemotherapy, 2012, Balaña-Fouce, Rafael et. al.
Synthesis of amide compounds of ferulic acid, and their stimulatory effects on insulin secretion in vitro
score: 1.2868296, Bioorganic & Medicinal Chemistry, 2003, Nomura, Eisaku et. al.
Interaction between miltefosine and amphotericin B: consequences for their activities towards intestinal epithelial cells and Leishmania donovani promastigotes in vitro.
score: 1.2867223, Antimicrobial agents and chemotherapy, 2006, Ménez, Cécile et. al.
Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase
score: 1.286695, Bioorganic & Medicinal Chemistry Letters, 2004, Song, Aimin et. al.
Exploring the possible binding sites at the interface of triosephosphate isomerase dimer as a potential target for anti-tripanosomal drug design
score: 1.2866597, Bioorganic & Medicinal Chemistry Letters, 2004, Espinoza-Fonseca, L.Michel; Trujillo-Ferrara, José G.
Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2′-deoxycytidines
score: 1.286604, Bioorganic & Medicinal Chemistry Letters, 2008, Sumino, Masanori et. al.
Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87).
score: 1.2864621, Antimicrobial agents and chemotherapy, 2001, Barnard, F M; Maxwell, A
A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor
score: 1.2863154, Bioorganic & Medicinal Chemistry Letters, 2004, Montembault, Mickaël et. al.
Fe(II) phthalocyanine catalyzed oxidation of dGMP by molecular oxygen
score: 1.2862768, Bioorganic & Medicinal Chemistry Letters, 2009, Kuznetsova, Aleksandra A. et. al.
Chloroalkyl piperazine and nitrogen mustard porphyrins: synthesis and anticancer activity
score: 1.2862588, Bioorganic & Medicinal Chemistry, 2004, Guo, Can-Cheng; Tong, Rong-Biao; Li, Ke-Lai
Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.
score: 1.2862175, Antimicrobial agents and chemotherapy, 2007, Sluis-Cremer, Nicolas et. al.
Synthesis and cytotoxic activities of group 3 metal complexes having monoanionic tridentate ligands
score: 1.286177, European Journal of Medicinal Chemistry, 2010, Saturnino, Carmela et. al.
TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).
score: 1.2861337, Antimicrobial agents and chemotherapy, 2005, Robin, F et. al.
Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones
score: 1.2860166, Bioorganic & Medicinal Chemistry, 2003, Ram, Vishnu Ji et. al.
Synthesis of diacylamines and the preparation of α-amino-acylureas, a new type of α-amino acid derivatives
score: 1.2859841, Bioorganic & Medicinal Chemistry Letters, 1998, Weisz, Imre et. al.
Exploring QSAR on 3-aminopyrazoles as antitumor agents for their inhibitory activity of CDK2/cyclin A
score: 1.2859814, European Journal of Medicinal Chemistry, 2006, Samanta, Soma et. al.
Activation and stabilization of chymotrypsin in Microdomains of poly(ethylenimine) derivatives. A model of in vivo environment
score: 1.2859169, Bioorganic & Medicinal Chemistry Letters, 1998, Suh, Junghun; Lee, Young-sam; Han, Sanghwa
Synthesis of glycosyl phosphoramidates: novel isosteric analogues of glycosyl phosphates
score: 1.2858857, Bioorganic & Medicinal Chemistry Letters, 2001, Kannan, Thanukrishnan et. al.
Multiple catalytic aldolase antibodies suitable for chemical programming
score: 1.2858424, Bioorganic & Medicinal Chemistry Letters, 2009, Goswami, Rajib Kumar et. al.
In vitro activities of garenoxacin (BMS-284756) against Haemophilus influenzae isolates with different fluoroquinolone susceptibilities.
score: 1.2857937, Antimicrobial agents and chemotherapy, 2003, Pérez-Vázquez, María et. al.
Resistance to cefepime and cefpirome due to a 4-amino-acid deletion in the chromosome-encoded AmpC beta-lactamase of a Serratia marcescens clinical isolate.
score: 1.2857805, Antimicrobial agents and chemotherapy, 2004, Mammeri, Hedi et. al.
Non-thiol farnesyltransferase inhibitors: the concept of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors
score: 1.2857388, European Journal of Medicinal Chemistry, 2000, Schlitzer, Martin; Sattler, Isabel
Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor.
score: 1.2857316, Antimicrobial agents and chemotherapy, 2003, Nguyen, Tammy T et. al.
Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer
score: 1.2857032, Bioorganic & Medicinal Chemistry Letters, 2012, Mock, Jason N. et. al.
Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.
score: 1.2856174, Antimicrobial agents and chemotherapy, 2008, Wyles, David L; Kaihara, Kelly A; Schooley, Robert T
On the conversion of structural analogues of ( S)-2-hydroxypropylphosphonic acid to epoxides by the final enzyme of fosfomycin biosynthesis in S. fradiae
score: 1.2856164, Bioorganic & Medicinal Chemistry Letters, 2008, Schweifer, Anna; Hammerschmidt, Friedrich
Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140.
score: 1.2855869, Antimicrobial agents and chemotherapy, 1998, Bantia, S et. al.
Synthesis and conformational studies of the tyvelose capped, Lewis-x like tetrasaccharide epitope of Trichinella spiralis
score: 1.2854998, Bioorganic & Medicinal Chemistry, 1996, Zhang, Jian; Otter, Albin; Bundle, David R.
Toward antiviral strategies that resist viral escape.
score: 1.2854655, Antimicrobial agents and chemotherapy, 2000, Endy, D; Yin, J
Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs
score: 1.2854443, European Journal of Medicinal Chemistry, 2005, Sriram, Dharmarajan; Yogeeswari, Perumal; Gopal, Gayatri
Preparations of vitamin D analogs, spirostanols and furostanols from diosgenin and their cytotoxic activities
score: 1.2853272, European Journal of Medicinal Chemistry, 2005, Quan, Hong-Ji et. al.
Synthesis and structure–affinity relationships at the central benzodiazepine receptor of pyridazino[4,3- b]indoles and Indeno[1,2- c]pyridazines
score: 1.2853253, Bioorganic & Medicinal Chemistry, 1999, Campagna, F; Palluotto, F; Carotti, A; Casini, G; Genchi, G
Anti-androgen receptor activity of apoptotic CK2 inhibitor CX4945 in human prostate cancer LNCap cells
score: 1.2853216, Bioorganic & Medicinal Chemistry Letters, 2012, Ryu, Byung Jun et. al.
Abscinazole-E2B, a practical and selective inhibitor of ABA 8′-hydroxylase CYP707A
score: 1.2851796, Bioorganic & Medicinal Chemistry, 2012, Okazaki, Mariko et. al.
Abscinazole-E2B, a practical and selective inhibitor of ABA 8′-hydroxylase CYP707A
score: 1.2851796, Bioorganic & Medicinal Chemistry, 2012, Okazaki, Mariko et. al.
Abscinazole-E2B, a practical and selective inhibitor of ABA 8′-hydroxylase CYP707A
score: 1.2851796, Bioorganic & Medicinal Chemistry, 2012, Okazaki, Mariko et. al.
( E)- and ( Z)-1,2,4-Triazolylchromanone oxime ethers as conformationally constrained antifungals
score: 1.2851118, Bioorganic & Medicinal Chemistry, 2004, Emami, Saeed et. al.
Probing the N-5 Region of the Indoloquinoline Alkaloid, Cryptolepine for Anticryptococcal Activity
score: 1.2851077, Bioorganic & Medicinal Chemistry, 1999, Ablordeppey, Seth Y et. al.
Chiral polyamines from reduction of polypeptides: asymmetric pyridoxamine-mediated transaminations
score: 1.2850916, Bioorganic & Medicinal Chemistry Letters, 2005, Zhou, Wenjun et. al.
Synthesis and pharmacological characterisation of 2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists
score: 1.2849984, Bioorganic & Medicinal Chemistry, 2003, Micheli, Fabrizio et. al.
Synthesis and α-adrenoceptor blocking activity of the enantiomers of benzyl-(2-chloroethyl)-[2-(2-methoxyphenoxy)-1-methylethl]amine hydrochloride
score: 1.2849955, Bioorganic & Medicinal Chemistry, 1997, Giardinà, Dario et. al.
Stereoselective synthesis, structural characterization, and properties of 1,2- O-isopropylidene-3- C-(5-phenyl-1,2,4-oxadiazol-3-yl)-β- d-psicopyranose
score: 1.2849592, Bioorganic & Medicinal Chemistry, 2005, Yu, Jianxin et. al.
β-Turn secondary structure and melanocortin ligands
score: 1.2849569, Bioorganic & Medicinal Chemistry, 2009, Haslach, Erica M.; Schaub, Jay W.; Haskell-Luevano, Carrie
Structure based virtual screening of GSK-3β: Importance of protein flexibility and induced fit
score: 1.2849554, Bioorganic & Medicinal Chemistry Letters, 2009, Mishra, Nibha et. al.
Design and synthesis of novel imidazo[1,2- a]quinoxalines as PDE4 inhibitors
score: 1.284936, Bioorganic & Medicinal Chemistry, 2004, Deleuze-Masquéfa, Carine et. al.
A new class of bioactivable self-immolative N,O-ligands
score: 1.2847707, European Journal of Medicinal Chemistry, 2012, Kuźnik, Nikodem et. al.
Synthesis of 3-deaza-3-nitro-2′-deoxyadenosine
score: 1.2847492, Bioorganic & Medicinal Chemistry, 2006, Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Comparison of levofloxacin, alatrofloxacin, and vancomycin for prophylaxis and treatment of experimental foreign-body-associated infection by methicillin-resistant Staphylococcus aureus.
score: 1.284659, Antimicrobial agents and chemotherapy, 2002, Vaudaux, Pierre et. al.
Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates
score: 1.2846346, European Journal of Medicinal Chemistry, 2004, Bhattacharjee, Apurba K. et. al.
Screening of Antifungal Azole Drugs and Agrochemicals with an Adapted alamarBlue-Based Assay Demonstrates Antibacterial Activity of Croconazole against Mycobacterium ulcerans.
score: 1.2846126, Antimicrobial agents and chemotherapy, 2012, Scherr, Nicole et. al.
Conformational preference for segetalins G and H, cyclic peptides with estrogen-like activity from seeds of Vaccaria segetalis
score: 1.2845127, Bioorganic & Medicinal Chemistry, 1997, Morita, Hiroshi et. al.
A novel approach toward bacteriochlorophylls- e and f
score: 1.2844395, Bioorganic & Medicinal Chemistry Letters, 1999, Tamiaki, Hitoshi; Omoda, Miki; Kubo, Masanobu
Differential effects of synthesized 2′-oxygenated chalcone derivatives: modulation of human cell cycle phase distribution
score: 1.2844145, Bioorganic & Medicinal Chemistry, 2004, Rao, Yerra Koteswara; Fang, Shih-Hua; Tzeng, Yew-Min
Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening
score: 1.2843779, Bioorganic & Medicinal Chemistry Letters, 2012, Procházková, Eliška et. al.
Anti-invasive activity of alkaloids and polyphenolics in vitro
score: 1.2843135, Bioorganic & Medicinal Chemistry, 1997, Parmar, Virinder S. et. al.
Anti-invasive activity of alkaloids and polyphenolics in vitro
score: 1.2843135, Bioorganic & Medicinal Chemistry, 1997, Parmar, Virinder S. et. al.
DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences
score: 1.2842185, Bioorganic & Medicinal Chemistry, 2012, Viswesh, Velliyur et. al.
DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences
score: 1.2842185, Bioorganic & Medicinal Chemistry, 2012, Viswesh, Velliyur et. al.
DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences
score: 1.2842185, Bioorganic & Medicinal Chemistry, 2012, Viswesh, Velliyur et. al.
A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca
score: 1.2841567, Bioorganic & Medicinal Chemistry Letters, 2012, Awakawa, Takayoshi et. al.
Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in target specificity.
score: 1.2840731, Antimicrobial agents and chemotherapy, 2002, Morris, Julia E; Pan, Xiao-Su; Fisher, L Mark
β-Cyclodextrin derivatives that inhibit anthrax lethal toxin
score: 1.2840087, Bioorganic & Medicinal Chemistry, 2006, Karginov, Vladimir A. et. al.
Peptide-cleaving agents for human islet amyloid polypeptide containing substrate recognition site based on quinoxaline: Cleavage efficiency enhanced by lowering substrate concentration
score: 1.2840082, Bioorganic & Medicinal Chemistry Letters, 2012, Chei, Woosuk; Ju, Heeyeon; Suh, Junghun
Inhibition of beta-lactamase II of Bacillus cereus by penamaldic derivatives of penicillins.
score: 1.2840032, Antimicrobial agents and chemotherapy, 2004, Navarro, Pilar Gutiérrez et. al.
Quantitative structure–antioxidant activity relationship of trans-resveratrol oligomers, trans-4,4′-dihydroxystilbene dimer, trans-resveratrol-3-O-glucuronide, glucosides: Trans-piceid, cis-piceid, trans-astringin and trans-resveratrol-4′-O-β-D-glucopyranoside
score: 1.2838874, European Journal of Medicinal Chemistry, 2010, Mikulski, Damian; Molski, Marcin
Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C.
score: 1.2838335, Antimicrobial agents and chemotherapy, 2011, Eguchi, Yoko et. al.
Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors
score: 1.2837423, European Journal of Medicinal Chemistry, 2012, Bruel, Amélie et. al.
Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors
score: 1.2837423, European Journal of Medicinal Chemistry, 2012, Bruel, Amélie et. al.
2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats
score: 1.283736, Bioorganic & Medicinal Chemistry, 2003, Pan, Kevin et. al.
New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells
score: 1.2837292, European Journal of Medicinal Chemistry, 2005, Brault, Laurent et. al.
Unexpected carbohydrate cross-binding by Escherichia coli heat-labile enterotoxin. Recognition of human and rabbit target cell glycoconjugates in comparison with cholera toxin
score: 1.2836695, Bioorganic & Medicinal Chemistry, 1996, Karlsson, Karl-Anders et. al.
Lipase-catalyzed preparation of optically active 1′-acetoxychavicol acetates and their structure–activity relationships in apoptotic activity against human leukemia HL-60 cells
score: 1.2836468, Bioorganic & Medicinal Chemistry, 2006, Azuma, Hideki et. al.
Synthesis and anti-inflammatory activities of N 4, N 5-disubstituted-3-methyl-1H-pyrazolo[3,4 -c]pyridazines
score: 1.2836406, Bioorganic & Medicinal Chemistry, 2001, Tewari, Ashish Kumar; Mishra, Anil
Stereoselective synthesis of 9-β- d-arabianofuranosyl guanine and 2-amino-9-(β- d-arabianofuranosyl)purine
score: 1.2835956, Bioorganic & Medicinal Chemistry Letters, 2005, Yu, Xue-Jun; Li, Gai-Xia; Qi, Xiou-Xiang; Deng, You-Quan
Synthesis of phosphoantigens: Scalable accesses to enantiomers of BrHPP and studies on N-HDMAPP synthesis
score: 1.2835579, Bioorganic & Medicinal Chemistry Letters, 2012, Brégeon, Delphine et. al.
Transformation of 8-prenylnaringenin by Absidia coerulea and Beauveria bassiana
score: 1.2835285, Bioorganic & Medicinal Chemistry Letters, 2012, Bartmańska, Agnieszka; Tronina, Tomasz; Huszcza, Ewa
Synthesis and use of 4-peptidylhydrazido- N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I
score: 1.2835158, European Journal of Medicinal Chemistry, 2009, Ivanov, Ivaylo et. al.
A new insight on the hypochlorous acid scavenging mechanism of tryptamine and tryptophan derivatives
score: 1.2834188, Bioorganic & Medicinal Chemistry Letters, 2010, Carvalho, Luísa C. et. al.
Structure-analysis of the HIV-1 integrase Y143C/R raltegravir resistance mutation in association with the secondary mutation T97A.
score: 1.2834079, Antimicrobial agents and chemotherapy, 2011, Reigadas, S et. al.
Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine
score: 1.2833511, Bioorganic & Medicinal Chemistry Letters, 2005, Mitra, Sayantan; Barrios, Amy M.
Synthesis and antimycotic activity of N-azolyl-2,4-dihydroxythiobenzamides
score: 1.2833025, Bioorganic & Medicinal Chemistry, 2003, Matysiak, Joanna; Niewiadomy, Andrzej
PER-7, an extended-spectrum beta-lactamase with increased activity toward broad-spectrum cephalosporins in Acinetobacter baumannii.
score: 1.2831452, Antimicrobial agents and chemotherapy, 2011, Bonnin, Rémy A et. al.
A set of new amino acid descriptors applied in prediction of MHC class I binding peptides
score: 1.2829599, European Journal of Medicinal Chemistry, 2009, Liang, Guizhao et. al.
Screening of active compounds as neuromedin U2 receptor agonist from natural products
score: 1.2829134, Bioorganic & Medicinal Chemistry Letters, 2005, Zheng, Xuxu; Hu, Yinghe; Liu, Jianhui; Ouyang, Keqing
In vitro activity of DX-619, a novel des-fluoro(6) quinolone, against a panel of Streptococcus pneumoniae mutants with characterized resistance mechanisms.
score: 1.282809, Antimicrobial agents and chemotherapy, 2006, Wickman, Paul A et. al.
In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins.
score: 1.282598, Antimicrobial agents and chemotherapy, 2005, Akoachere, Monique et. al.
Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives
score: 1.2825729, Bioorganic & Medicinal Chemistry, 2012, Barros, Francisco W.A. et. al.
Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives
score: 1.2825729, Bioorganic & Medicinal Chemistry, 2012, Barros, Francisco W.A. et. al.
Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives
score: 1.2825729, Bioorganic & Medicinal Chemistry, 2012, Barros, Francisco W.A. et. al.
Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.
score: 1.2824997, Antimicrobial agents and chemotherapy, 2012, Sandoz, Kelsi M et. al.
CHIPS binds to the phosphorylated N-terminus of the C5a-receptor
score: 1.2824358, Bioorganic & Medicinal Chemistry Letters, 2010, Bunschoten, Anton et. al.
Design, synthesis, and evaluation of N-aroyloxy-2-thiopyridones as DNA photocleaving reagents
score: 1.2823939, Bioorganic & Medicinal Chemistry, 1999, Blom, Petra et. al.
Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde
score: 1.2823891, European Journal of Medicinal Chemistry, 2012, Cui, Yongming et. al.
Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde
score: 1.2823891, European Journal of Medicinal Chemistry, 2012, Cui, Yongming et. al.
Synthesis and application of a novel, crystalline phosphoramidite monomer with Thiol Terminus, suitable for the synthesis of DNA conjugates
score: 1.2823833, Bioorganic & Medicinal Chemistry, 2001, Kupihár, Zoltán et. al.
Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-Amyloid plaques in brain
score: 1.2823743, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Xuedan et. al.
Synthesis of novel 9-O-N-aryl/aryl–alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects
score: 1.2823491, Bioorganic & Medicinal Chemistry, 2012, Basu, Anirban et. al.
In vivo antitumor activity of chitosan nanoparticles
score: 1.282311, Bioorganic & Medicinal Chemistry Letters, 2006, Qi, Lifeng; Xu, Zirong
Identification and biosynthesis of (E,E)-10,12-tetradecadienyl acetate in Spodoptera littoralis female sex pheromone gland
score: 1.2823065, Bioorganic & Medicinal Chemistry, 1997, Navarro, Isabel et. al.
Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica
score: 1.2822311, European Journal of Medicinal Chemistry, 2013, Yue, Grace G.L. et. al.
Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated fromInula helianthus-aquatica
score: 1.2822311, European Journal of Medicinal Chemistry, 2013, Yue, Grace G.L. et. al.
Efficient conjugation of oligonucleotides through aromatic oxime formation
score: 1.2821214, Bioorganic & Medicinal Chemistry Letters, 2009, Murat, Pierre et. al.
d-Glucosamine propanedithioacetal, an efficient chiral auxiliary in β-Lactam chemistry 1 Dedicated to Professor Sir Derek H. R. Barton. 1
score: 1.2820205, Bioorganic & Medicinal Chemistry, 1999, Anaya, Josefa et. al.
Multiple-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers.
score: 1.2820068, Antimicrobial agents and chemotherapy, 2004, Schmitt-Hoffmann, Anne et. al.
Synthesis of LIAZAL TM, a retinoic acid metabolism blocking agent (ramba) with potential clinical applications in oncology and dermatology
score: 1.281903, Bioorganic & Medicinal Chemistry Letters, 1998, Freyne, E. et. al.
Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication.
score: 1.2817252, Antimicrobial agents and chemotherapy, 2012, Schinazi, Raymond F et. al.
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
score: 1.2816438, Antimicrobial agents and chemotherapy, 2010, Lai, Ming-Tain et. al.
An unusual functional group interaction and its potential to reproduce steric and electrostatic features of the transition states of peptidolysis
score: 1.2816093, Bioorganic & Medicinal Chemistry, 2006, Gautier, Arnaud; Pitrat, Delphine; Hasserodt, Jens
Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs
score: 1.2814268, Bioorganic & Medicinal Chemistry, 2005, Lee, Su-Lin et. al.
Synthesis of 9-acridinyl sulfur derivatives: sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells
score: 1.2813677, European Journal of Medicinal Chemistry, 2004, Santelli-Rouvier, Christiane et. al.
Design and synthesis of a Tat-related gene transporter: A tool for carrying the adenovirus vector into cells
score: 1.2811599, Bioorganic & Medicinal Chemistry Letters, 2006, Kida, Shinya et. al.
Exploring QSAR of thiazole and thiadiazole derivatives as potent and selective human adenosine A 3 receptor antagonists using FA and GFA techniques
score: 1.2811344, Bioorganic & Medicinal Chemistry, 2005, Bhattacharya, Prosenjit; Leonard, J. Thomas; Roy, Kunal
Synthesis and binding properties of cyclopentane analogues of myo-inositol 1,4,5-tris(phosphate)
score: 1.2811342, Bioorganic & Medicinal Chemistry, 2004, Moris, Marc-Antoine et. al.
New approach for high-throughput screening of drug activity on Plasmodium liver stages.
score: 1.2811289, Antimicrobial agents and chemotherapy, 2006, Gego, Audrey et. al.
Analysis of binding sites for the new small-molecule CCR5 antagonist TAK-220 on human CCR5.
score: 1.2809973, Antimicrobial agents and chemotherapy, 2005, Nishikawa, Masao et. al.
Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives
score: 1.2808509, Bioorganic & Medicinal Chemistry, 2003, Moreau, Pascale et. al.
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
score: 1.2806521, European Journal of Medicinal Chemistry, 2012, Thapa, Pritam et. al.
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
score: 1.2806521, European Journal of Medicinal Chemistry, 2012, Thapa, Pritam et. al.
Towards an understanding of drug resistance in malaria: Three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building
score: 1.2806042, Bioorganic & Medicinal Chemistry, 1999, Lemcke, Thomas et. al.
Synthesis of Chiral Hydroxylated Enones as Potential Anti-tumor Agents
score: 1.2805669, Bioorganic & Medicinal Chemistry Letters, 2012, Shing, Tony K.M.; Wu, Ho T.; Kwok, H.F.; Lau, Clara B.S.
Cobaltpolyoxometalate-catalyzed cyclization of glucal with aryl amines: Synthesis of 2,4-disubstituted tetrahydroquinolines
score: 1.2805594, Bioorganic & Medicinal Chemistry Letters, 2007, Rafiee, Ezzat; Azad, A.
Synthesis, cellular uptake and animal toxicity of a tetra(carboranylphenyl)-tetrabenzoporphyrin
score: 1.2805382, Bioorganic & Medicinal Chemistry, 2006, Gottumukkala, Vijay et. al.
Acyloxymethyl as a drug protecting group. Part 6
score: 1.2805103, Bioorganic & Medicinal Chemistry, 2000, Lopes, Francisca; Moreira, Rui; Iley, Jim
Synthesis and pharmacological evaluation of newer substituted benzoxazepine derivatives as potent anticonvulsant agents
score: 1.2805001, European Journal of Medicinal Chemistry, 2004, Bajaj, Kiran; Archana, ; Kumar, Ashok
Synthesis and evaluation of new 5-fluorouracil antitumor cell differentiating derivatives
score: 1.2801988, Bioorganic & Medicinal Chemistry, 2003, Domı́nguez, José F. et. al.
Synthesis of 1- d- and 1- l- myo-inosityl 2- N-acetamido-2-deoxy-α- d-glucopyranoside establishes substrate specificity of the Mycobacterium tuberculosis enzyme AcGI deacetylase
score: 1.2801791, Bioorganic & Medicinal Chemistry, 2003, Nicholas, Gillian M. et. al.
Functional expression of the Aspergillus flavus PKS–NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid
score: 1.2801736, Bioorganic & Medicinal Chemistry Letters, 2009, Seshime, Yasuyo et. al.
Asitrilobins C and D: two new cytotoxic mono-tetrahydrofuran annonaceous acetogenins from Asimina triloba seeds
score: 1.2801688, Bioorganic & Medicinal Chemistry, 2000, Woo, Mi-Hee; Chung, Soon-Ok; Kim, Dal-Hwan
Enantioselective Henry (nitroaldol) reaction catalyzed by axially chiral guanidines
score: 1.2801566, Bioorganic & Medicinal Chemistry Letters, 2009, Ube, Hitoshi; Terada, Masahiro
α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents
score: 1.2801467, Bioorganic & Medicinal Chemistry Letters, 2003, Jain, R. et. al.
Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists
score: 1.2799343, Bioorganic & Medicinal Chemistry, 2006, Naganawa, Atsushi et. al.
Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent
score: 1.2798839, Bioorganic & Medicinal Chemistry Letters, 2012, Rane, Rajesh A.; Gutte, Shweta D.; Sahu, Niteshkumar U.
Synthetic, structural and biochemical studies of polynuclear platinum(II) complexes with heterocyclic ligands
score: 1.2798765, European Journal of Medicinal Chemistry, 2009, Rubino, S. et. al.
CoMFA analysis of the human β 1-adrenoceptor binding affinity of a series of phenoxypropanolamines
score: 1.2798344, European Journal of Medicinal Chemistry, 2002, Louis, Simon N et. al.
Ceftaroline versus Isolates from Animal Bite Wounds: Comparative In Vitro Activities against 243 Isolates, Including 156 Pasteurella Species Isolates.
score: 1.2796841, Antimicrobial agents and chemotherapy, 2012, Goldstein, Ellie J C et. al.
Synthesis and anticonvulsant activity of enaminones
score: 1.2795791, European Journal of Medicinal Chemistry, 2003, Eddington, Natalie D et. al.
The aminoglycoside antibiotic kanamycin damages DNA bases in Escherichia coli: caffeine potentiates the DNA-damaging effects of kanamycin while suppressing cell killing by ciprofloxacin in Escherichia coli and Bacillus anthracis.
score: 1.2795636, Antimicrobial agents and chemotherapy, 2012, Kang, Tina Manzhu et. al.
The Co-crystal Structure of Ubiquitin Carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
score: 1.2795518, Bioorganic & Medicinal Chemistry Letters, 2012, Davies, Christopher W. et. al.
Non-covalent complexes between bis-β-carbolines and double-stranded DNA: A study by electrospray ionization FT-ICR mass spectrometry (I)
score: 1.2795267, Bioorganic & Medicinal Chemistry Letters, 2007, Dong, Xiaochun et. al.
Synthesis of a d-Ala- d-Ala peptide isostere via olefin cross-metathesis and evaluation of vancomycin binding
score: 1.279432, Bioorganic & Medicinal Chemistry Letters, 2010, Quinn, Ryan K. et. al.
In Vivo Comparison of CXA-101 (FR264205) with and without Tazobactam versus Piperacillin-Tazobactam Using Human Simulated Exposures against Phenotypically Diverse Gram-Negative Organisms.
score: 1.2793287, Antimicrobial agents and chemotherapy, 2012, Bulik, Catharine C et. al.
Antifungal activity of eupolauridine and its action on DNA topoisomerases.
score: 1.2793201, Antimicrobial agents and chemotherapy, 2002, Khan, Shabana I et. al.
Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6'-Ib' gene cassettes in Pseudomonas aeruginosa.
score: 1.2791608, Antimicrobial agents and chemotherapy, 2002, Dubois, Véronique et. al.
Antimicrobial activity of novel furanonaphthoquinone analogs.
score: 1.2789625, Antimicrobial agents and chemotherapy, 1998, Nagata, K; Hirai, K I; Koyama, J; Wada, Y; Tamura, T
In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone.
score: 1.2787968, Antimicrobial agents and chemotherapy, 1999, Takahata, M et. al.
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
score: 1.2787747, Antimicrobial agents and chemotherapy, 2012, Kirby, Karen A et. al.
The crystal structures of copper(II), manganese(II), and nickel(II) complexes of a ( Z)-2-hydroxy- N′-(2-oxoindolin-3-ylidene) benzohydrazide—potential antitumor agents
score: 1.2786973, Bioorganic & Medicinal Chemistry Letters, 2007, Zhong, Xia et. al.
Evaluation of anti-inflammatory and antioxidant activities of mixed-ligand Cu(II) complexes of dien and its Schiff dibases with heterocyclic aldehydes and 2-amino-2-thiazoline
score: 1.2786226, Bioorganic & Medicinal Chemistry Letters, 2006, Pontiki, E. et. al.
Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells
score: 1.2785814, Bioorganic & Medicinal Chemistry, 2006, Quang, Dang Ngoc et. al.
Chemoenzymatic synthesis of high-mannose type HIV-1 gp120 glycopeptides
score: 1.2785565, Bioorganic & Medicinal Chemistry Letters, 2003, Singh, Suddham; Ni, Jiahong; Wang, Lai-Xi
Synthesis and characterization of the monomer ruthenium complex of hypocrellin B
score: 1.2785409, Bioorganic & Medicinal Chemistry Letters, 2005, Zhou, Jiahong et. al.
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.
score: 1.2784219, Antimicrobial agents and chemotherapy, 2002, Fikkert, Valery et. al.
A new class of bioactivable self-immolative N,O-ligands
score: 1.2784053, European Journal of Medicinal Chemistry, 2012, Kuźnik, Nikodem et. al.
Trisubstituted benzene leukotriene B 4 receptor antagonists: Synthesis and structure-activity relationships
score: 1.2783892, Bioorganic & Medicinal Chemistry, 1997, Konno, Mitoshi et. al.
Trisubstituted benzene leukotriene B 4 receptor antagonists: Synthesis and structure-activity relationships
score: 1.2783892, Bioorganic & Medicinal Chemistry, 1997, Konno, Mitoshi et. al.
Carbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacter baumannii.
score: 1.2782901, Antimicrobial agents and chemotherapy, 2011, Bonnin, Rémy A et. al.
Poly(styrene- alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates
score: 1.2782548, Bioorganic & Medicinal Chemistry Letters, 2009, Fang, Weijun et. al.
Biosynthesis of 20-hydroxyecdysone in Ajuga hairy roots
score: 1.2782522, Bioorganic & Medicinal Chemistry, 1999, Ohyama, Kiyoshi et. al.
Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo
score: 1.2782156, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Ji-Quan et. al.
Carbamate-linked cationic lipids for gene delivery
score: 1.2781793, Bioorganic & Medicinal Chemistry, 2008, Liu, Dongliang et. al.
Mutagenesis of Zinc Ligand Residue Cys221 Reveals Plasticity in the IMP-1 Metallo-β-Lactamase Active Site.
score: 1.2781185, Antimicrobial agents and chemotherapy, 2012, Horton, Lori B et. al.
Synthesis, NMR characterization and in vitro cytotoxicity evaluation of new poly(oxyethylene aminophosphonate)s
score: 1.2781076, European Journal of Medicinal Chemistry, 2010, Kraicheva, I. et. al.
Schizophyllan–folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier
score: 1.2778857, Bioorganic & Medicinal Chemistry Letters, 2005, Hasegawa, Teruaki et. al.
Photoinduced cleavage of DNA by bromofluoroacetophenone–pyrrolecarboxamide conjugates
score: 1.2778606, Bioorganic & Medicinal Chemistry Letters, 2003, Wender, Paul A.; Jeon, Raok
A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors.
score: 1.2778572, Antimicrobial agents and chemotherapy, 2002, Motakis, Dimitrios; Parniak, Michael A
Therapeutic drug monitoring of piperacillin-tazobactam using spent dialysate effluent in patients receiving continuous venovenous hemodialysis.
score: 1.2778074, Antimicrobial agents and chemotherapy, 2011, Connor, Michael J et. al.
In vitro activities of two ketolides, HMR 3647 and HMR 3004, against gram-positive bacteria.
score: 1.2778052, Antimicrobial agents and chemotherapy, 1999, Malathum, K; Coque, T M; Singh, K V; Murray, B E
Synthesis of novel 2,3-dihydro-1,4-dioxino[2,3- g]quinoline derivatives as potential antitumor agents
score: 1.2776276, Bioorganic & Medicinal Chemistry, 2004, Vázquez, M.T; Romero, M; Pujol, M.D
Non-stochastic quadratic fingerprints and LDA-based QSAR models in hit and lead generation through virtual screening: theoretical and experimental assessment of a promising method for the discovery of new antimalarial compounds
score: 1.2775896, European Journal of Medicinal Chemistry, 2006, Montero-Torres, Alina et. al.
Novel A-ring homodimeric C-3-carbamate analogues of 1α,25-dihydroxyvitamin D 3: Synthesis and preliminary biological evaluation
score: 1.2773346, Bioorganic & Medicinal Chemistry, 2006, Oves, Daniel et. al.
1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIa phospholipase A 2: X-ray structure of the complex and interfacial selection of inhibitors from a structural library
score: 1.2773308, Bioorganic & Medicinal Chemistry Letters, 1999, Bryant, M.D. et. al.
Cellular uptake of two fluoroketolides, HMR 3562 and HMR 3787, by human polymorphonuclear neutrophils in vitro.
score: 1.2772476, Antimicrobial agents and chemotherapy, 2001, Abdelghaffar, H; Vazifeh, D; Labro, M T
Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafungin.
score: 1.2771472, Antimicrobial agents and chemotherapy, 2009, van de Sande, Wendy W J et. al.
Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action.
score: 1.2771374, Antimicrobial agents and chemotherapy, 2005, Scordi-Bello, Irini A et. al.
MMP inhibition by barbiturate homodimers
score: 1.2770885, Bioorganic & Medicinal Chemistry Letters, 2013, Wang, Jun et. al.
Design and synthesis of prodrugs of the rat selective toxicant norbormide
score: 1.2770813, Bioorganic & Medicinal Chemistry, 2012, Rennison, David et. al.
Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.
score: 1.2770462, Antimicrobial agents and chemotherapy, 2000, Onishi, J et. al.
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.
score: 1.2768031, Antimicrobial agents and chemotherapy, 2004, Ward, Shannon L et. al.
Successful long-term treatment of cerebral nocardiosis with unexpectedly low doses of linezolid in an immunocompromised patient receiving complex polytherapy.
score: 1.2767713, Antimicrobial agents and chemotherapy, 2012, Pea, Federico et. al.
Gene-silencing properties of siRNAs that contain internal amide-bond linkages
score: 1.2767519, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Wei; Desaulniers, Jean-Paul
Gene-silencing properties of siRNAs that contain internal amide-bond linkages
score: 1.2767519, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Wei; Desaulniers, Jean-Paul
Gene-silencing properties of siRNAs that contain internal amide-bond linkages
score: 1.2767519, Bioorganic & Medicinal Chemistry Letters, 2012, Gong, Wei; Desaulniers, Jean-Paul
Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation
score: 1.2766843, European Journal of Medicinal Chemistry, 2008, Sawicki, Marcin et. al.
Synthesis of β-difluorine-containing amino acids
score: 1.2766103, Bioorganic & Medicinal Chemistry Letters, 1998, Keqiang Li, ; Leriche, Caroline; Liu, Hung-wen
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds
score: 1.2765784, Bioorganic & Medicinal Chemistry, 2004, Hocková, Dana et. al.
Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids
score: 1.2765691, European Journal of Medicinal Chemistry, 2004, N’Goka, Victor et. al.
Reaction of Thiols with 7-Methylbenzopentathiepin
score: 1.2765631, Bioorganic & Medicinal Chemistry Letters, 2003, Chatterji, Tonika; Gates, Kent S.
Solid-phase synthesis of oligonucleotides containing a Bipyridine ligand at the 3′-3′ inversion of polarity site
score: 1.27627, Bioorganic & Medicinal Chemistry Letters, 2001, Galeone, Aldo et. al.
Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles
score: 1.2762421, Bioorganic & Medicinal Chemistry Letters, 2005, Qi, Lifeng; Xu, Zirong; Jiang, Xia; Li, Yan; Wang, Minqi
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK
score: 1.2761651, Bioorganic & Medicinal Chemistry, 2006, Smith, Jeffrey A. et. al.
High therapeutic index of factor C Sushi peptides: potent antimicrobials against Pseudomonas aeruginosa.
score: 1.2761524, Antimicrobial agents and chemotherapy, 2001, Yau, Y H; Ho, B; Tan, N S; Ng, M L; Ding, J L
Design, Synthesis, and Molecular Hybrids of Caudatin and Cinnamic Acids as Novel Anti-hepatitis B Virus Agents
score: 1.2759881, European Journal of Medicinal Chemistry, 2012, Wang, Li-Jun et. al.
Self-aggregation of zinc chlorophylls possessing perfluoroalkyl chains in fluorous solvents: Selective extraction of the self-aggregates with fluorous phase and accelerated formation of the ordered supramolecules in this phase
score: 1.2759335, Bioorganic & Medicinal Chemistry Letters, 2007, Tamiaki, Hitoshi; Nishiyama, Takashi; Shibata, Reiko
Activity-based fluorescent probes for monitoring sulfatase activity
score: 1.2757586, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Hyun-Joo; Rhee, Hyun-Woo; Hong, Jong-In
Chemoenzymatic synthesis of ( S) and ( R)-propranolol and sotalol employing one-pot lipase resolution protocol
score: 1.2753377, Bioorganic & Medicinal Chemistry Letters, 2004, Kamal, Ahmed; Sandbhor, Mahendra; Ali Shaik, Ahmad
2-Benzyl-2-methylsuccinic acid as inhibitor for carboxypeptidase A. synthesis and evaluation
score: 1.2752484, Bioorganic & Medicinal Chemistry, 1999, Lee, Mijoon; Jin, Yonghao; Kim, Dong H.
Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.
score: 1.2750566, Antimicrobial agents and chemotherapy, 2004, Petraitis, Vidmantas et. al.
N-(Phenoxyalkyl)amides as MT1and MT2ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II
score: 1.2750521, Bioorganic & Medicinal Chemistry, 2013, Carocci, Alessia et. al.
N-(Phenoxyalkyl)amides as MT1and MT2ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II
score: 1.2750521, Bioorganic & Medicinal Chemistry, 2013, Carocci, Alessia et. al.
In vitro activities of membrane-active peptides against gram-positive and gram-negative aerobic bacteria.
score: 1.2748729, Antimicrobial agents and chemotherapy, 1998, Giacometti, A et. al.
The antitumor agent doxorubicin binds to Fanconi anemia group F protein
score: 1.274814, Bioorganic & Medicinal Chemistry, 2012, Kusayanagi, Tomoe et. al.
The antitumor agent doxorubicin binds to Fanconi anemia group F protein
score: 1.274814, Bioorganic & Medicinal Chemistry, 2012, Kusayanagi, Tomoe et. al.
Development of a whole-cell assay for peptidoglycan biosynthesis inhibitors.
score: 1.2746204, Antimicrobial agents and chemotherapy, 2002, Barbosa, Maria D F S et. al.
A novel side-bridged hybrid phosphonate/acetate pendant cyclam: Synthesis, characterization, and 64Cu small animal PET imaging
score: 1.2746153, Bioorganic & Medicinal Chemistry, 2009, Boswell, C. Andrew et. al.
A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases
score: 1.2745948, Bioorganic & Medicinal Chemistry, 1997, Wang, Ruo et. al.
Structure of kainic acid totally elucidated by NMR and molecular modelling
score: 1.2745843, Bioorganic & Medicinal Chemistry, 1997, Todeschi, Nathalie et. al.
Synthesis, antiproliferative and antifungal activities of some 2-(2,4-dihydroxyphenyl)-4 H-3,1-benzothiazines
score: 1.2745396, Bioorganic & Medicinal Chemistry, 2006, Matysiak, Joanna
The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation
score: 1.2744872, Bioorganic & Medicinal Chemistry, 2005, Gazivoda, Tatjana et. al.
2,4-diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: a novel class of antimalarials.
score: 1.2743759, Antimicrobial agents and chemotherapy, 2005, Nduati, Eunice; Hunt, Sonya; Kamau, Eddy M; Nzila, Alexis
Binding of actinomycin C 1 (D) and actinomin to base-modified oligonucleotide duplexes with parallel chain orientation
score: 1.2741996, Bioorganic & Medicinal Chemistry, 2006, Li, Hong; Peng, Xiaohua; Leonard, Peter; Seela, Frank
Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives
score: 1.2741615, European Journal of Medicinal Chemistry, 2012, Hernández-Covarrubias, Carlos et. al.
Influence of the Protein Kinase C Activator Phorbol Myristate Acetate on the Intracellular Activity of Antibiotics against Hemin- and Menadione-Auxotrophic Small-Colony Variant Mutants of Staphylococcus aureus and Their Wild-Type Parental Strain in Human THP-1 Cells.
score: 1.274157, Antimicrobial agents and chemotherapy, 2012, Garcia, Laetitia G et. al.
Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm
score: 1.2741446, Bioorganic & Medicinal Chemistry, 2008, Brown, Toni et. al.
Synthesis of (2 S,3 R)- β-methyltyrosine catalyzed by tyrosine phenol-lyase
score: 1.2741198, Bioorganic & Medicinal Chemistry Letters, 1999, Kim, Kyonghee; Cole, Philip A.
Synthesis and antiproliferative activity of some 5-substituted 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles
score: 1.2740464, European Journal of Medicinal Chemistry, 2006, Matysiak, Joanna et. al.
Synthesis and antimicrobial activity of new 3-(1- R-3(5)-methyl-4-nitroso-1 H-5(3)-pyrazolyl)-5-methylisoxazoles
score: 1.2739575, Bioorganic & Medicinal Chemistry, 2000, Aiello, Enrico et. al.
Anthranilic acid based CCK 1 antagonists: the 2-indole moiety may represent a “needle” according to the recent homonymous concept
score: 1.2739028, European Journal of Medicinal Chemistry, 2004, Varnavas, Antonio et. al.
A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities
score: 1.2738526, Bioorganic & Medicinal Chemistry, 2006, Yang, Li et. al.
Synthesis of aminophosphonate haptens for an aminoacylation reaction between methyl glucoside and a β-alanyl ester
score: 1.2737926, Bioorganic & Medicinal Chemistry Letters, 2000, Lintunen, Timo; Yli-Kauhaluoma, Jari T
In vitro activity of ceftaroline against gram-positive and gram-negative pathogens isolated from patients in Canadian hospitals in 2009.
score: 1.2736378, Antimicrobial agents and chemotherapy, 2011, Karlowsky, James A et. al.
Novel curcumin analogs targeting TNF-induced NF-κB activation and proliferation in human leukemic KBM-5 cells
score: 1.2735958, Bioorganic & Medicinal Chemistry, 2006, Zambre, Ajit P. et. al.
Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi.
score: 1.2735656, Antimicrobial agents and chemotherapy, 2002, Saraiva, Victor B et. al.
Tethered phytic acid as a probe for measuring phytase activity
score: 1.2734974, Bioorganic & Medicinal Chemistry Letters, 2005, Berry, Duane F.; Berry, David A.
Non-electrostatic complexes with DNA: towards novel synthetic gene delivery systems
score: 1.2734711, Bioorganic & Medicinal Chemistry Letters, 2000, Soto, Javier et. al.
Stereochemical influence on lipase-mediated hydrolysis and biological activity of stampidine and other stavudine phosphoramidates
score: 1.2734512, Bioorganic & Medicinal Chemistry, 2005, Venkatachalam, T.K.; Samuel, P.; Uckun, F.M.
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs.
score: 1.2734508, Antimicrobial agents and chemotherapy, 2001, Maga, G et. al.
Synthesis of nucleoside 5′-boranophosphorothioate derivatives using an H-boranophosphonate monoester as a precursor
score: 1.2734115, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Natsuhisa; Takayama, Yuji; Ando, Kaori; Wada, Takeshi
Synthesis of nucleoside 5′-boranophosphorothioate derivatives using an H-boranophosphonate monoester as a precursor
score: 1.2734115, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Natsuhisa; Takayama, Yuji; Ando, Kaori; Wada, Takeshi
Characterization of the anticonvulsant profile of valpromide derivatives
score: 1.2732452, Bioorganic & Medicinal Chemistry, 2004, Tasso, Silvina M et. al.
Theoretical quantitative structure–activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes
score: 1.2732377, Bioorganic & Medicinal Chemistry, 2005, Iori, F.; Fonseca, R. da; Ramos, M. João; Menziani, M.C.
Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo [2,1-b]-thiazol-4-yliden) acetonitrile derivatives
score: 1.2732141, Bioorganic & Medicinal Chemistry Letters, 2012, Patil, Vijay S. et. al.
Trigoxyphins H and I: Two new Daphnane Diterpenoids from Trigonostemon xyphophylloides
score: 1.2731708, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Biao et. al.
Allylmagnolol, a novel magnolol derivative as potent antioxidant
score: 1.273138, Bioorganic & Medicinal Chemistry, 2003, Li, Chi-Yuan; Wang, Yvonne; Hu, Ming-Kuan
Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-γ-activated murine macrophages
score: 1.2729632, Bioorganic & Medicinal Chemistry, 2005, Fang, Shih-Hua; Rao, Yerra Koteswara; Tzeng, Yew-Min
Synthesis and biological activity of novel mycophenolic acid conjugates containing nitro-acridine/acridone derivatives
score: 1.2728977, European Journal of Medicinal Chemistry, 2012, Malachowska-Ugarte, Magdalena et. al.
Synthesis and biological activity of novel mycophenolic acid conjugates containing nitro-acridine/acridone derivatives
score: 1.2728977, European Journal of Medicinal Chemistry, 2012, Malachowska-Ugarte, Magdalena et. al.
Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series
score: 1.2728475, Bioorganic & Medicinal Chemistry, 2000, Bonnet, Béatrice et. al.
In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases.
score: 1.2728284, Antimicrobial agents and chemotherapy, 2009, Endimiani, Andrea; Choudhary, Yuvraj; Bonomo, Robert A
Kinetic study of the inflammatory response in Streptococcus pneumoniae experimental pneumonia treated with the ketolide HMR 3004.
score: 1.2727694, Antimicrobial agents and chemotherapy, 2001, Duong, M; Simard, M; Bergeron, Y; Bergeron, M G
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors
score: 1.2726654, Bioorganic & Medicinal Chemistry Letters, 2012, Gealageas, Ronan et. al.
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors
score: 1.2726654, Bioorganic & Medicinal Chemistry Letters, 2012, Gealageas, Ronan et. al.
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors
score: 1.2726654, Bioorganic & Medicinal Chemistry Letters, 2012, Gealageas, Ronan et. al.
Synthesis and anti-tubercular evaluation of 4-quinolylhydrazones
score: 1.2726203, Bioorganic & Medicinal Chemistry, 2002, Savini, Luisa et. al.
Synthesis and hybridization of 2′- O-methyl-RNAs incorporating 2′- O-carbamoyluridine and unique participation of the carbamoyl group in U–G base pair
score: 1.2726113, Bioorganic & Medicinal Chemistry, 2009, Seio, Kohji et. al.
In vitro activity of the new glycopeptide LY333328 against multiply resistant gram-positive clinical isolates.
score: 1.2725885, Antimicrobial agents and chemotherapy, 1998, García-Garrote, F; Cercenado, E; Alcalá, L; Bouza, E
TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.
score: 1.2725784, Antimicrobial agents and chemotherapy, 2004, Poirel, Laurent; Mammeri, Hedi; Nordmann, Patrice
Aza-THIP and related analogues of THIP as GABA C antagonists
score: 1.2724649, Bioorganic & Medicinal Chemistry, 2003, Krehan, Dorte et. al.
Automated synthesis, characterization, and structural analysis of oligonucleotide C-3′-radical precursors
score: 1.2723693, Bioorganic & Medicinal Chemistry, 2006, Lahoud, Georges et. al.
Triple helix stabilization properties of oligonucleotides containing 8-amino-2′-deoxyguanosine
score: 1.2721963, Bioorganic & Medicinal Chemistry Letters, 1998, García, Ramon Güimil et. al.
Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.
score: 1.2721756, Antimicrobial agents and chemotherapy, 1999, Talarico, C L et. al.
Preliminary mapping of a putative inhibitor-binding pocket for human immunodeficiency virus type 1 integrase inhibitors.
score: 1.2721543, Antimicrobial agents and chemotherapy, 2006, Lee, Deborah J; Robinson, W Edward
Synthesis of β-(1→6)-branched β-(1→3) glucohexaose and its analogues containing an α-(1→3) linked bond with antitumor activity
score: 1.2720154, Bioorganic & Medicinal Chemistry, 2003, Ning, Jun et. al.
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.
score: 1.2719788, Antimicrobial agents and chemotherapy, 2003, Stuyver, Lieven J et. al.
Prediction of milk/plasma concentration ratios of drugs and environmental pollutants
score: 1.2719289, European Journal of Medicinal Chemistry, 2009, Abraham, Michael H.; Gil-Lostes, Javier; Fatemi, Mohammad
Antimicrobial action of carbon monoxide-releasing compounds.
score: 1.271891, Antimicrobial agents and chemotherapy, 2007, Nobre, Lígia S et. al.
Characterization of l-glutamine:2-deoxy- scyllo-inosose aminotransferase ( tbmB) from Streptomyces tenebrarius
score: 1.2718275, Bioorganic & Medicinal Chemistry Letters, 2005, Kharel, Madan K. et. al.
Identification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazole.
score: 1.2718162, Antimicrobial agents and chemotherapy, 2012, Sionov, Edward et. al.
3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter
score: 1.2715487, Bioorganic & Medicinal Chemistry, 2006, Cini, Nicoletta et. al.
Adenosine receptors: new opportunities for future drugs
score: 1.2712889, Bioorganic & Medicinal Chemistry, 1998, Poulsen, Sally-Ann; Quinn, Ronald J
Stereospecific syntheses of trans-vinyldioxidosqualene and β-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors
score: 1.2712571, Bioorganic & Medicinal Chemistry, 2000, Viola, Franca et. al.
Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir.
score: 1.2711312, Antimicrobial agents and chemotherapy, 2006, Rameix-Welti, M A et. al.
Biguanide-atovaquone synergy against Plasmodium falciparum in vitro.
score: 1.2711173, Antimicrobial agents and chemotherapy, 2002, Jones, K; Ward, S A
Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances
score: 1.271029, Scientia Pharmaceutica, 2011, Paliwal, Sarvesh K. et. al.
Unnatural base pairs between 2- and 6-substituted purines and 2-oxo(1H)pyridine for expansion of the genetic alphabet
score: 1.2709087, Bioorganic & Medicinal Chemistry Letters, 2004, Hirao, Ichiro et. al.
Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives
score: 1.2708196, European Journal of Medicinal Chemistry, 2009, Kulkarni, Ajaykumar; Patil, Sangamesh A.; Badami, Prema S.
Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera D unal. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum
score: 1.2707795, Bioorganic & Medicinal Chemistry, 2001, Matsuda, Hisashi et. al.
Treatment and prevention of Staphylococcus epidermidis experimental biomaterial-associated infection by bactericidal peptide 2.
score: 1.2707332, Antimicrobial agents and chemotherapy, 2006, Kwakman, Paulus H S et. al.
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation
score: 1.2707299, Bioorganic & Medicinal Chemistry, 2012, Parmenopoulou, Vanessa et. al.
Synthetic studies on oligosaccharides composed of 5-thioglucopyranose units
score: 1.270641, Bioorganic & Medicinal Chemistry, 2005, Morii, Yasuharu et. al.
Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs.
score: 1.2705588, Antimicrobial agents and chemotherapy, 2004, Mellado, E et. al.
Positioning of 99mTc-chelators influences radiolabeling, stability and biodistribution of Affibody molecules
score: 1.2705521, Bioorganic & Medicinal Chemistry Letters, 2009, Ekblad, Torun et. al.
Photonuclease activity of Taylor's blue
score: 1.2705121, Bioorganic & Medicinal Chemistry Letters, 1999, Mohammad, Taj; Morrison, Harry
Adenine and Deazaadenine Nucleoside and Deoxynucleoside Analogues: Inhibition of Viral Replication of Sheep MVV (In Vitro Model for HIV) and Bovine BHV-1
score: 1.2704018, Bioorganic & Medicinal Chemistry, 2002, Salvatori, Daniela et. al.
Pharmacokinetic and pharmacodynamic study of the human immunodeficiency virus protease inhibitor amprenavir after multiple oral dosing.
score: 1.2703954, Antimicrobial agents and chemotherapy, 2001, Sadler, B M; Gillotin, C; Lou, Y; Stein, D S
Synthesis and SAR studies of 3-allyl-4-prenyloxyaniline amides as potent 15-lipoxygenase inhibitors
score: 1.2703888, Bioorganic & Medicinal Chemistry, 2012, Jabbari, Atena et. al.
Selection of a screening panel of rhinoviral serotypes
score: 1.2703533, Bioorganic & Medicinal Chemistry Letters, 2012, Tomkinson, Nick; Wenlock, Mark; McCrae, Christopher
Selection of a screening panel of rhinoviral serotypes
score: 1.2703533, Bioorganic & Medicinal Chemistry Letters, 2012, Tomkinson, Nick; Wenlock, Mark; McCrae, Christopher
Selection of a screening panel of rhinoviral serotypes
score: 1.2703533, Bioorganic & Medicinal Chemistry Letters, 2012, Tomkinson, Nick; Wenlock, Mark; McCrae, Chris
Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives
score: 1.2702414, Bioorganic & Medicinal Chemistry, 2005, Crnolatac, Ivo et. al.
Polymer-Supported reagents for methylphosphorylation and phosphorylation of carbohydrates
score: 1.2702382, Bioorganic & Medicinal Chemistry Letters, 2002, Parang, Keykavous
Long-Acting Fentanyl Analogues: Synthesis and Pharmacology of N-(1-Phenylpyrazolyl)- N-(1-phenylalkyl-4-piperidyl)propanamides
score: 1.2702096, Bioorganic & Medicinal Chemistry, 2002, Jagerovic, Nadine et. al.
Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720
score: 1.2702013, Bioorganic & Medicinal Chemistry, 2006, Matsumoto, Norimasa et. al.
Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies
score: 1.2700889, Bioorganic & Medicinal Chemistry Letters, 2006, Padmanabhan, Seetharamaiyer et. al.
An estradiol-conjugate for radiolabelling with 177Lu: an attempt to prepare a radiotherapeutic agent
score: 1.2700358, Bioorganic & Medicinal Chemistry, 2005, Banerjee, Sharmila et. al.
Application of comparative molecular field analysis to dopamine d 2 partial agonists
score: 1.2700157, Bioorganic & Medicinal Chemistry, 1999, McGaughey, Georgia B; Mewshaw, Richard E
Synthesis and primary cytotoxicity evaluation of 3-[[(3-phenyl-4(3H)-quinazolinone-2-yl)mercaptoacetyl]hydrazono]-1H-2-indolinones
score: 1.2700119, European Journal of Medicinal Chemistry, 2003, Gürsoy, Aysel; Karalı, Nilgün
Cyclosporin analogs inhibit in vitro growth of Cryptosporidium parvum.
score: 1.2699967, Antimicrobial agents and chemotherapy, 1998, Perkins, M E; Wu, T W; Le Blancq, S M
Design and synthesis of novel amino-substituted xanthenones and benzo[ b]xanthenones: Evaluation of their antiproliferative activity and their ability to overcome multidrug resistance toward MES-SA/D × 5 cells
score: 1.2699897, Bioorganic & Medicinal Chemistry, 2006, Kostakis, Ioannis K. et. al.
Generic Vancomycin Enriches Resistant Subpopulations of Staphylococcus aureus after Exposure in a Neutropenic Mouse Thigh Infection Model.
score: 1.269965, Antimicrobial agents and chemotherapy, 2012, Rodriguez, Carlos A et. al.
Investigation of the nucleotide triphosphate substrate specificity of Homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1)
score: 1.269852, Bioorganic & Medicinal Chemistry Letters, 2012, Xue, Mengyang et. al.
Investigation of the nucleotide triphosphate substrate specificity of Homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1)
score: 1.269852, Bioorganic & Medicinal Chemistry Letters, 2012, Xue, Mengyang et. al.
Investigation of the nucleotide triphosphate substrate specificity of Homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1)
score: 1.269852, Bioorganic & Medicinal Chemistry Letters, 2012, Xue, Mengyang et. al.
Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: Cell death mechanisms and determination of crystal structure
score: 1.2698002, European Journal of Medicinal Chemistry, 2013, Hranjec, Marijana et. al.
Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: Cell death mechanisms and determination of crystal structure
score: 1.2698002, European Journal of Medicinal Chemistry, 2013, Hranjec, Marijana et. al.
Synthesis and evaluation of novel chromogenic peptidase substrates based on 9-(4′-aminophenyl)-10-methylacridinium salts as diagnostic tools in clinical bacteriology
score: 1.26978, Bioorganic & Medicinal Chemistry Letters, 2008, Anderson, Rosaleen J. et. al.
Combining multiple classifications of chemical structures using consensus clustering
score: 1.2697512, Bioorganic & Medicinal Chemistry, 2012, Chu, Chia-Wei; Holliday, John D.; Willett, Peter
Combining multiple classifications of chemical structures using consensus clustering
score: 1.2697512, Bioorganic & Medicinal Chemistry, 2012, Chu, Chia-Wei; Holliday, John D.; Willett, Peter
Combining multiple classifications of chemical structures using consensus clustering
score: 1.2697512, Bioorganic & Medicinal Chemistry, 2012, Chu, Chia-Wei; Holliday, John D.; Willett, Peter
Two-photon uncaging: New prospects in neuroscience and cellular biology
score: 1.2697347, Bioorganic & Medicinal Chemistry, 2010, Warther, D. et. al.
Antimalarial activities of aminooxy compounds.
score: 1.2696886, Antimicrobial agents and chemotherapy, 2000, Berger, B J
Synthesis and characterization of copper(II) and zinc(II)-based potential chemotherapeutic compounds: Their biological evaluation viz. DNA binding profile, cleavage and antimicrobial activity
score: 1.2695663, European Journal of Medicinal Chemistry, 2012, Tabassum, Sartaj et. al.
Synthesis and characterization of copper(II) and zinc(II)-based potential chemotherapeutic compounds: Their biological evaluation viz. DNA binding profile, cleavage and antimicrobial activity
score: 1.2695663, European Journal of Medicinal Chemistry, 2012, Tabassum, Sartaj et. al.
Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme.
score: 1.2695538, Antimicrobial agents and chemotherapy, 2001, Wang, Y; Bruenn, J A; Queener, S F; Cody, V
Synthesis and antiproliferative activity of benzo[ d]isothiazole hydrazones
score: 1.2694151, European Journal of Medicinal Chemistry, 2006, Vicini, Paola et. al.
A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii
score: 1.2692955, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Wei-Quan; Song, Zhi-Jun; Xu, Han-Hong
Synthesis and biological activity of 3,3-Diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells
score: 1.2692293, Bioorganic & Medicinal Chemistry, 2003, Tagmose, Tina M et. al.
Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi
score: 1.2691481, Bioorganic & Medicinal Chemistry, 2001, Girault, Sophie et. al.
Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue.
score: 1.2690428, Antimicrobial agents and chemotherapy, 2004, Müller, Markus; dela Peña, Amparo; Derendorf, Hartmut
Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis
score: 1.268785, Bioorganic & Medicinal Chemistry Letters, 2009, Hashimoto, Makoto et. al.
Direct solid-phase synthesis of octreotide conjugates
score: 1.268758, Bioorganic & Medicinal Chemistry, 1999, Hsieh, Hsing-Pang et. al.
A quantitative structure–activity relationship study on some series of anthranilic acid-based matrix metalloproteinase inhibitors
score: 1.2687211, Bioorganic & Medicinal Chemistry, 2005, Gupta, S.P.; Kumaran, S.
Facile and efficient aromatization of 1,4-dihydropyridines with M(NO 3) 2· XH 2O, TNCB, TBAP and HMTAI and preparation of deuterium labeled dehydronifedipine from nifedipine- d 3
score: 1.2686191, Bioorganic & Medicinal Chemistry Letters, 2010, Shaikh, Ajam C.; Chen, Chinpiao
In vitro activities of LY333328 and comparative agents against nosocomial gram-positive pathogens collected in a 1997 global surveillance study.
score: 1.2685162, Antimicrobial agents and chemotherapy, 2000, Zeckel, M L; Preston, D A; Allen, B S
Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues
score: 1.2685149, Bioorganic & Medicinal Chemistry, 2004, Tardy, Christelle et. al.
Inhibitors of nitric oxide production from the bark of Myrica rubra: structures of new biphenyl type diarylheptanoid glycosides and taraxerane type triterpene
score: 1.2684994, Bioorganic & Medicinal Chemistry, 2002, Tao, Jing et. al.
A new efficient synthesis of efaroxan
score: 1.2684594, Bioorganic & Medicinal Chemistry Letters, 1999, Mayer, P.; Brunel, P.; Imbert, T.
Triple combination of oseltamivir, amantadine, and ribavirin displays synergistic activity against multiple influenza virus strains in vitro.
score: 1.2684511, Antimicrobial agents and chemotherapy, 2009, Nguyen, Jack T et. al.
Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure–activity relationship
score: 1.2684338, Bioorganic & Medicinal Chemistry, 2006, Kanbe, Yoshitake et. al.
Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target
score: 1.2682843, Bioorganic & Medicinal Chemistry, 2005, Capobianco, Massimo L. et. al.
Effects of acyl versus aminoacyl conjugation on the properties of antimicrobial peptides.
score: 1.2682835, Antimicrobial agents and chemotherapy, 2005, Radzishevsky, Inna S et. al.
Carbohydrate-centered maleimide cluster as a new type of templates for multivalent peptide assembling
score: 1.2680419, Bioorganic & Medicinal Chemistry, 2003, Wang, Lai-Xi; Ni, Jiahong; Singh, Suddham
Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a multidrug-resistant adenocarcinoma cell line
score: 1.2680341, Bioorganic & Medicinal Chemistry Letters, 1999, Al-Omar, Anouar et. al.
Measurement of effects of antibiotics in bioluminescent Staphylococcus aureus RN4220.
score: 1.2680326, Antimicrobial agents and chemotherapy, 2001, Tenhami, M; Hakkila, K; Karp, M
Hybrid liposomes affect cellular lipid constituents and caveolae structures
score: 1.2678792, Bioorganic & Medicinal Chemistry Letters, 2012, Cao, Ke et. al.
Novel synthetic ligands for targeted PET imaging and radiotherapy of copper
score: 1.2677036, Bioorganic & Medicinal Chemistry Letters, 2007, Chong, Hyun-Soon et. al.
Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues
score: 1.2676793, Bioorganic & Medicinal Chemistry, 2001, Marco, José L et. al.
Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation
score: 1.2676668, Bioorganic & Medicinal Chemistry, 2002, Sup Shim, Joong et. al.
The ODN probes conjugating the Cu(II) complex enhance the luminol chemiluminescence by assembling on the DNA template
score: 1.2675726, Bioorganic & Medicinal Chemistry, 2010, Taniguchi, Yosuke et. al.
Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-( N-phthalimidophenyl)} pyrimidines 1 1 Taken in part from the Ph.D. thesis (2003) of Emerson Peter da S. Falcão
score: 1.2675264, European Journal of Medicinal Chemistry, 2006, Falcão, Emerson Peter da S. et. al.
QSAR modeling of blood:air and tissue:air partition coefficients using theoretical descriptors
score: 1.2674521, Bioorganic & Medicinal Chemistry, 2005, Katritzky, Alan R. et. al.
Synthesis and anticancer evaluation of some new hydrazone derivatives of 2,6-dimethylimidazo[2,1- b][1,3,4]thiadiazole-5-carbohydrazide
score: 1.2673409, European Journal of Medicinal Chemistry, 2003, Terzioglu, Nalan; Gürsoy, Aysel
A new method for introducing amidate linkages in oligonucleotides using phosphoramidite chemistry
score: 1.2672307, Bioorganic & Medicinal Chemistry Letters, 1999, Davis, Peter W.; Osgood, Steven A.
Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity
score: 1.2672077, European Journal of Medicinal Chemistry, 2005, Jacquemard, Ulrich et. al.
8-(Sulfostyryl)xanthines: water-soluble A 2A-selective adenosine receptor antagonists 1 1 Preliminary results were presented at the International Symposium “Purines ’96” in Milan, Italy; abstract published in Drug Dev. Res. 1996, 37, 112.
score: 1.2671815, Bioorganic & Medicinal Chemistry, 1998, Müller, Christa E. et. al.
Synthesis and characterization of a DNA analogue stabilized by mercapto C-nucleoside induced disulfide bonding
score: 1.2671637, Bioorganic & Medicinal Chemistry Letters, 2004, Hatano, Akihiko; Makita, Seiji; Kirihara, Masayuki
Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents
score: 1.267108, Bioorganic & Medicinal Chemistry, 2012, Yang, Xian-Hui et. al.
Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents
score: 1.267108, Bioorganic & Medicinal Chemistry, 2012, Yang, Xian-Hui et. al.
In vitro and in vivo antibacterial activities of DW286, a new fluoronaphthyridone antibiotic.
score: 1.266943, Antimicrobial agents and chemotherapy, 2002, Yun, Hee-Jeong et. al.
Biophysical and biochemical properties of oligodeoxynucleotides containing 4′- C- and 5′- C-substituted thymidines
score: 1.2667848, Bioorganic & Medicinal Chemistry Letters, 1999, Wang, Guangyi et. al.
Two methylene groups in phospholipids distinguish between apoptosis and necrosis for tumor cells
score: 1.266696, Bioorganic & Medicinal Chemistry Letters, 2006, Nagami, Hideaki et. al.
Investigating the binding interactions of galantamine with β-amyloid peptide
score: 1.2666362, Bioorganic & Medicinal Chemistry Letters, 2013, Rao, Praveen P.N.; Mohamed, Tarek; Osman, Wesseem
Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists
score: 1.266624, Bioorganic & Medicinal Chemistry Letters, 2012, Dzierba, Carolyn D. et. al.
Incorporation of α- and β-LNA (Locked nucleic acid) monomers in oligodeoxynucleotides with polarity reversals
score: 1.2664304, Bioorganic & Medicinal Chemistry Letters, 2001, Christensen, Nanna K; Dahl, Britta M; Nielsen, Poul
Synthesis of (3,4) β-Methylenecepham and (3,4) β-Methylene-carbacepham via intramolecular carbene addition to double bond
score: 1.2664121, Bioorganic & Medicinal Chemistry, 2003, Korda, Anna; Winiarski, Jerzy
Binding properties of oligonucleotides containing a modified 2′-deoxyuridine with a thymine ended linker to pair with 2′-deoxyadenosine
score: 1.2664044, Bioorganic & Medicinal Chemistry Letters, 2002, Savy, Pascal et. al.
3D-QSAR, Synthesis, and antimicrobial activity of 1-Alkylpyridinium Compounds as Potential Agents to Improve Food Safety
score: 1.2662824, European Journal of Medicinal Chemistry, 2005, Rodríguez-Morales, Sergio et. al.
Picrodendrin and related terpenoid antagonists reveal structural differences between ionotropic GABA receptors of mammals and insects
score: 1.2662336, Bioorganic & Medicinal Chemistry, 1998, Ozoe, Yoshihisa et. al.
Synthesis and anti-HSV-1 evaluation of new 3 H -benzo[ b ]pyrazolo[3,4- h ]-1,6-naphthyridines and 3 H -pyrido[2,3- b ]pyrazolo[3,4- h ]-1,6-naphthyridines
score: 1.2662133, Organic and Medicinal Chemistry Letters, 2012, Bernardino, Alice MR et. al.
Neomycin improves cationic lipid-mediated transfection of DNA in human cells
score: 1.2661806, Bioorganic & Medicinal Chemistry Letters, 2005, Napoli, Sara et. al.
Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells
score: 1.2661779, European Journal of Medicinal Chemistry, 2012, Khelili, Smail et. al.
Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: Application to prediction of Caco-2 cell permeability
score: 1.2661498, Bioorganic & Medicinal Chemistry, 2005, Fujikawa, Masaaki et. al.
The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction
score: 1.2661144, Bioorganic & Medicinal Chemistry Letters, 2002, Ambroise, Yves; Boger, Dale L.
Design, synthesis, and evaluation of aza inhibitors of chorismate mutase
score: 1.2659048, Bioorganic & Medicinal Chemistry, 2004, Hediger, Mark E.
Development of a yeast assay for rapid screening of inhibitors of human-derived Pneumocystis carinii dihydrofolate reductase.
score: 1.2658576, Antimicrobial agents and chemotherapy, 2002, Ma, Liang; Jia, Qiuyao; Kovacs, Joseph A
5′-(2-Nitrophenylalkanoyl)-2′-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation
score: 1.2658464, Bioorganic & Medicinal Chemistry, 2003, Liu, Bin; Hu, Longqin
Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease
score: 1.2658345, Bioorganic & Medicinal Chemistry Letters, 2006, Yang, Qing et. al.
Rational construction of eukaryotic OFF-riboswitches that downregulate internal ribosome entry site-mediated translation in response to their ligands
score: 1.2658244, Bioorganic & Medicinal Chemistry Letters, 2012, Ogawa, Atsushi
Design of antineoplastic agents based on the ‘2-phenylnaphthalene-type’ structural pattern—synthesis and biological activity studies of 11 H-indolo[3.2- c]quinoline derivatives
score: 1.2656773, European Journal of Medicinal Chemistry, 2003, He, Ling et. al.
Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.
score: 1.265388, Antimicrobial agents and chemotherapy, 1999, Li, C et. al.
Investigation of the nucleotide triphosphate substrate specificity of Homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1)
score: 1.2653739, Bioorganic & Medicinal Chemistry Letters, 2012, Xue, Mengyang et. al.
In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus.
score: 1.2653266, Antimicrobial agents and chemotherapy, 2003, Firsov, Alexander A et. al.
Synthesis of highly selective fluorescent peptide probes for metal ions: Tuning selective metal monitoring with secondary structure
score: 1.2653212, Bioorganic & Medicinal Chemistry, 2008, Joshi, Bishnu Prasad; Lee, Keun-Hyeung
Phenotypic and molecular characterization of Mycobacterium tuberculosis isolates resistant to both isoniazid and ethambutol.
score: 1.2652346, Antimicrobial agents and chemotherapy, 2005, Parsons, Linda M et. al.
Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors
score: 1.2652336, Bioorganic & Medicinal Chemistry, 2000, Silvestri, Romano et. al.
The composition and sequence specificity of Pro-Ala-Lys-OH for the thrombolytic activities of P6A and related oligopeptides
score: 1.2649799, Bioorganic & Medicinal Chemistry, 2004, Zhao, Ming et. al.
Syntheses and receptor-binding studies of derivatives of the opioid antagonist naltrexone
score: 1.264939, Bioorganic & Medicinal Chemistry, 2004, Uwai, Koji et. al.
Development of rationally designed DNA N6 adenine methyltransferase inhibitors
score: 1.264852, Bioorganic & Medicinal Chemistry Letters, 2012, Hobley, Gerard et. al.
Development of rationally designed DNA N6 adenine methyltransferase inhibitors
score: 1.264852, Bioorganic & Medicinal Chemistry Letters, 2012, Hobley, Gerard et. al.
Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di- N-Oxide derivatives
score: 1.2648144, Bioorganic & Medicinal Chemistry, 2003, Zarranz, Belén et. al.
Self-organizing molecular field analysis on α 1a-adrenoceptor dihydropyridine antagonists
score: 1.2645453, Bioorganic & Medicinal Chemistry, 2003, Li, Minyong; Du, Lüpei; Wu, Bin; Xia, Lin
Binding of vancomycin group antibiotics to d-alanine and d-lactate presenting self-assembled monolayers
score: 1.2644869, Bioorganic & Medicinal Chemistry, 2000, Cooper, Matthew A. et. al.
A new generation of fluorescent chemosensors demonstrate improved analyte detection sensitivity and photobleaching resistance
score: 1.2644657, Bioorganic & Medicinal Chemistry Letters, 1999, Rothman, Jeffrey H.; Still, W.Clark
Design and synthesis of novel antihypertensive drugs
score: 1.2643521, Bioorganic & Medicinal Chemistry Letters, 2003, Moutevelis-Minakakis, P et. al.
Generation of a small library of cyclodepsipeptide PF1022A analogues using a cyclization-Cleavage method with oxime resin
score: 1.2642867, Bioorganic & Medicinal Chemistry Letters, 2002, Lee, Byung H et. al.
Synthesis and inotropic activity of hydroindene derivatives
score: 1.2642679, Bioorganic & Medicinal Chemistry, 1999, Sevillano, Luis G. et. al.
Exploring converse molecular mechanisms of anti-HIV-1 antibodies using a synthetic CXCR4 mimic
score: 1.2642424, Bioorganic & Medicinal Chemistry Letters, 2012, Haußner, Christina; Möbius, Kalle; Eichler, Jutta
Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8
score: 1.2641971, Bioorganic & Medicinal Chemistry, 2005, Bianchini, Gianluca et. al.
Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A 1 receptor
score: 1.2641744, European Journal of Medicinal Chemistry, 2004, Baraldi, Pier Giovanni et. al.
Epoxide-containing side chains enhance antiproliferative activity of paullones
score: 1.2641387, European Journal of Medicinal Chemistry, 2005, Xie, Xu et. al.
Small-molecule microarrays: Development of novel linkers and an efficient detection method for bound proteins
score: 1.2640918, Bioorganic & Medicinal Chemistry Letters, 2006, Kurosu, Michio; Mowers, Williams A.
Direct labelling of peptides with 2-[ 18F]fluoro-2-deoxy- d-glucose ([ 18F]FDG)
score: 1.2639632, Bioorganic & Medicinal Chemistry Letters, 2009, Wuest, Frank et. al.
New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT 3) receptor agonists for the treatment of constipation
score: 1.2639583, Bioorganic & Medicinal Chemistry, 2003, Imanishi, Naoki et. al.
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae
score: 1.2639442, Bioorganic & Medicinal Chemistry, 2012, Nguyen, Phi Hung et. al.
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae
score: 1.2639442, Bioorganic & Medicinal Chemistry, 2012, Nguyen, Phi Hung et. al.
Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer
score: 1.263934, Bioorganic & Medicinal Chemistry Letters, 2012, Antoon, James W.; Beckman, Barbara S.
Searching for allosteric effects via QSAR. Part II
score: 1.2637878, Bioorganic & Medicinal Chemistry, 2003, Garg, Rajni et. al.
Quantitative structure–activity relationship to predict toxicological properties of benzene derivative compounds
score: 1.2636867, Bioorganic & Medicinal Chemistry, 2005, González, Maykel Pérez et. al.
Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors
score: 1.263671, Bioorganic & Medicinal Chemistry, 2006, Chahboune, Nadia et. al.
Oxime bond formation for the covalent attachment of oligonucleotides on glass support
score: 1.2636313, Bioorganic & Medicinal Chemistry Letters, 2003, Defrancq, Eric et. al.
In vitro antimicrobial activity of MSI-78, a magainin analog.
score: 1.2636188, Antimicrobial agents and chemotherapy, 1998, Fuchs, P C; Barry, A L; Brown, S D
Two-color labeling of temporally defined protein populations in mammalian cells
score: 1.2635036, Bioorganic & Medicinal Chemistry Letters, 2008, Beatty, Kimberly E.; Tirrell, David A.
Comparison of the dark and light-induced toxicity of thio and seleno analogues of the thiopyrylium dye AA1
score: 1.2634393, Bioorganic & Medicinal Chemistry, 2004, Detty, Michael R; Gibson, Scott L; Hilf, Russell
A transesterification reaction is implicated in the covalent binding of benzo[ b]acronycine anticancer agents with DNA and glutathion
score: 1.2634067, Bioorganic & Medicinal Chemistry, 2004, David-Cordonnier, Marie-Hélène et. al.
Triple combinations of lower and longer alkyl gallates and oxacillin improve antibiotic synergy against methicillin-resistant Staphylococcus aureus.
score: 1.2633568, Antimicrobial agents and chemotherapy, 2009, Shibata, Hirofumi et. al.
Orally active cephalosporins: synthesis, structure–activity relationships and oral absorption of 3-[( E) and ( Z)-2-Substituted vinyl]-cephalosporins
score: 1.2633396, Bioorganic & Medicinal Chemistry, 2000, Yamamoto, Hirofumi et. al.
Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
score: 1.263193, Antimicrobial agents and chemotherapy, 2012, Horita, Yasuhiro et. al.
An effective method for the in situ synthesis of DNA–CPG conjugates using chemical ligation technology as tools for SNP analysis
score: 1.2631626, Bioorganic & Medicinal Chemistry Letters, 2007, Ohkubo, Akihiro et. al.
Ecological effects of perorally administered pivmecillinam on the normal vaginal microflora.
score: 1.2630505, Antimicrobial agents and chemotherapy, 2005, Sullivan, Asa et. al.
Evaluation of siRNAs that contain internal variable-length spacer linkages
score: 1.2629557, Bioorganic & Medicinal Chemistry Letters, 2012, Efthymiou, Tim C. et. al.
Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents
score: 1.2628622, Bioorganic & Medicinal Chemistry Letters, 2008, Park, Myunji; Canzio, Daniele; Bruice, Thomas C.
Conjugation of oligonucleotides via an electrophilic tether: N-chloroacetamidohexyl phosphoramidite reagent
score: 1.2628543, Bioorganic & Medicinal Chemistry Letters, 1998, Guzaev, Andrei; Manoharan, Muthiah
Recent Developments and Biological Activities of Thiazolidinone Derivatives: A Review
score: 1.2628381, Bioorganic & Medicinal Chemistry, 2012, Jain, Abhishek Kumar et. al.
Synthesis of a novel ester analog of nucleic acids bearing a serine backbone
score: 1.262746, Bioorganic & Medicinal Chemistry Letters, 2006, Murata, Asako; Wada, Takeshi
Population pharmacokinetics of pyrimethamine and sulfadoxine in children treated for congenital toxoplasmosis.
score: 1.2627334, Antimicrobial agents and chemotherapy, 2004, Corvaisier, Stéphane et. al.
Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria.
score: 1.2626962, Antimicrobial agents and chemotherapy, 2004, Pukrittayakamee, Sasithon et. al.
Pharmacodynamic assessment of cefprozil against Streptococcus pneumoniae: implications for breakpoint determinations.
score: 1.2625967, Antimicrobial agents and chemotherapy, 2000, Nicolau, D P et. al.
Novel fluorescent cephalosporins: Synthesis, antimicrobial activity and photodynamic inactivation of antibiotic resistant bacteria
score: 1.262501, European Journal of Medicinal Chemistry, 2013, Xiao, Jian-Min et. al.
A method for terminus proteomics: Selective isolation and labeling of N-terminal peptide from protein through transamination reaction
score: 1.2624328, Bioorganic & Medicinal Chemistry Letters, 2009, Sonomura, Kazuhiro et. al.
Tetrahydropyrrolo[3,2- c]azepin-4-ones as a new class of cytotoxic compounds
score: 1.2623828, Bioorganic & Medicinal Chemistry, 2006, Martínez, Roberto et. al.
The consequences of scoring docked ligand conformations using free energy correlations
score: 1.262357, European Journal of Medicinal Chemistry, 2007, Spyrakis, Francesca et. al.
Virtual inhibitory quotient predicts response to ritonavir boosting of indinavir-based therapy in human immunodeficiency virus-infected patients with ongoing viremia.
score: 1.2623335, Antimicrobial agents and chemotherapy, 2002, Shulman, Nancy et. al.
Site-selective glycosylation of subtilisin Bacillus lentus causes dramatic increases in esterase activity
score: 1.2622615, Bioorganic & Medicinal Chemistry, 2000, Lloyd, Richard C; Davis, Benjamin G; Jones, J.Bryan
Synthesis of New 3,4,5-Trisubstituted Isothiazoles as Effective Inhibitory Agents of Enteroviruses
score: 1.2621694, Bioorganic & Medicinal Chemistry, 1999, Cutrı̀, Christian C.C. et. al.
Design, synthesis and structure–Activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease
score: 1.2621678, Bioorganic & Medicinal Chemistry, 2003, Toda, Narihiro et. al.
New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain
score: 1.2621386, European Journal of Medicinal Chemistry, 2012, Hussain, Hidayat et. al.
Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists
score: 1.2617515, Bioorganic & Medicinal Chemistry, 2003, Zhou, Zhang-Lin et. al.
New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones with various substituents at position 1.
score: 1.2617397, Antimicrobial agents and chemotherapy, 2004, Hayashi, Norihiro; Nakata, Yoshihiro; Yazaki, Akira
Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae Isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22.
score: 1.2616868, Antimicrobial agents and chemotherapy, 2005, Reinert, Ralf René; Al-Lahham, Adnan
Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli
score: 1.26161, Bioorganic & Medicinal Chemistry Letters, 2003, Strauss, Erick; Begley, Tadhg P
Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis
score: 1.2615757, Bioorganic & Medicinal Chemistry, 2009, Marinec, Paul S. et. al.
Synthesis of fluorescence-Labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior
score: 1.261517, Bioorganic & Medicinal Chemistry Letters, 2003, Hakogi, Toshikazu et. al.
Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II)
score: 1.2614912, Bioorganic & Medicinal Chemistry, 2006, Fukuhara, Kiyoshi et. al.
A generic building block for C- and N-terminal protein-labeling and protein-immobilization
score: 1.2614832, Bioorganic & Medicinal Chemistry, 2006, Watzke, Anja et. al.
The interaction between tylophorine B and TMV RNA
score: 1.2613841, Bioorganic & Medicinal Chemistry Letters, 2006, Xi, Zhen; Zhang, Ruoyu; Yu, Zhihong; Ouyang, Di
One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation
score: 1.2613263, Bioorganic & Medicinal Chemistry, 2006, Li, Jian et. al.
Methylation of Imidazoline Related Compounds Leads to Loss of α2-Adrenoceptor Affinity. Synthesis and Biological Evaluation of Selective I1 Imidazoline Receptor Ligands
score: 1.2612972, Bioorganic & Medicinal Chemistry, 2012, Schann, Stephan et. al.
Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice.
score: 1.2612899, Antimicrobial agents and chemotherapy, 2000, Abruzzo, G K et. al.
Inhibitors of the fungal cell wall. Synthesis of 4-aryl-4- N-arylamine-1-butenes and related compounds with inhibitory activities on β(1–3) glucan and chitin synthases
score: 1.2612727, Bioorganic & Medicinal Chemistry, 2000, Urbina, Juan M et. al.
Synthesis and biological evaluation of new fluorine substituted derivatives as angiotensin II receptor antagonists with anti-hypertension and anti-tumor effects
score: 1.2612382, Bioorganic & Medicinal Chemistry, 2012, Da, Ya-jing et. al.
Synthesis and biological evaluation of new fluorine substituted derivatives as angiotensin II receptor antagonists with anti-hypertension and anti-tumor effects
score: 1.2612382, Bioorganic & Medicinal Chemistry, 2012, Da, Ya-jing et. al.
Synthesis and biological evaluation of new fluorine substituted derivatives as angiotensin II receptor antagonists with anti-hypertension and anti-tumor effects
score: 1.2612382, Bioorganic & Medicinal Chemistry, 2012, Da, Ya-jing et. al.
Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines—Synthesis and ‘structure–activity’ relationship
score: 1.2612006, Bioorganic & Medicinal Chemistry Letters, 2012, Ivachtchenko, Alexandre V. et. al.
Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines—Synthesis and ‘structure–activity’ relationship
score: 1.2612006, Bioorganic & Medicinal Chemistry Letters, 2012, Ivachtchenko, Alexandre V. et. al.
Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines—Synthesis and ‘structure–activity’ relationship
score: 1.2612006, Bioorganic & Medicinal Chemistry Letters, 2012, Ivachtchenko, Alexandre V. et. al.
In vivo activity of evernimicin (SCH 27899) against methicillin-resistant Staphylococcus aureus in experimental infective endocarditis.
score: 1.261074, Antimicrobial agents and chemotherapy, 2001, Boucher, H W et. al.
Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr 5,12, Lys 7]-polyphemusin II)
score: 1.2610478, Bioorganic & Medicinal Chemistry, 1998, Tamamura, Hirokazu et. al.
Frequency of voriconazole resistance in vitro among Spanish clinical isolates of Candida spp. According to breakpoints established by the Antifungal Subcommittee of the European Committee on Antimicrobial Susceptibility Testing.
score: 1.261009, Antimicrobial agents and chemotherapy, 2011, Cuenca-Estrella, M et. al.
Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides
score: 1.2609286, Bioorganic & Medicinal Chemistry Letters, 2002, Zhang, Jianxing et. al.
Interstrand disulfide cross-linking of internal sugar residues in duplex RNA
score: 1.2608574, Bioorganic & Medicinal Chemistry, 2000, Alefelder, Stefan; Sigurdsson, Snorri Th
Amino hydroxamic acids as potent inhibitors of leukotriene A 4 hydrolase
score: 1.2608484, Bioorganic & Medicinal Chemistry, 1995, Hogg, J.Heather et. al.
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis
score: 1.2608449, Bioorganic & Medicinal Chemistry, 2012, Gröblacher, Barbara; Kunert, Olaf; Bucar, Franz
Enzymatic resolution of (±)-γ-cyclohomogeraniol and conversion of its ( S)-Isomer to ( S)-γ-coronal, the ambergris odorant 1 In memory of Professor Sir Derek H. R. Barton with full respect and thanks for his unforgettable encouragement to K. M. 1 2 Preparative Bioorganic Chemistry, Part 19. For Part 18, see ref [1]. 2
score: 1.2607797, Bioorganic & Medicinal Chemistry, 1999, Horiuchi, Sayo; Takikawa, Hirosato; Mori, Kenji
Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases.
score: 1.2607429, Antimicrobial agents and chemotherapy, 2011, Brown, Jessica A et. al.
Discovery of selective aldo-keto reductase ligands—an on-bead assay strategy
score: 1.2607413, Bioorganic & Medicinal Chemistry Letters, 2005, Dixon, Seth et. al.
Corrigendum to “New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies” [Bioorg. Med. Chem. Lett. 18 (2008) 4959]
score: 1.2607139, Bioorganic & Medicinal Chemistry Letters, 2010, Sundriyal, Sandeep et. al.
Synthesis and electrochemical study of a new chiral tris-catecholamide analogue of enterobactin
score: 1.260519, Bioorganic & Medicinal Chemistry Letters, 1999, Cheraïti, N.; Brik, M.E.; Gaudemer, A.; Kunesh, G.
Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii.
score: 1.2604785, Antimicrobial agents and chemotherapy, 2000, Cushion, M T; Collins, M; Hazra, B; Kaneshiro, E S
C-Aryl 5a-carba-β-D-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
score: 1.2604243, Bioorganic & Medicinal Chemistry, 2012, Ohtake, Yoshihito et. al.
Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum
score: 1.2602805, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lulu et. al.
Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum
score: 1.2602805, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lulu et. al.
Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum
score: 1.2602805, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lulu et. al.
Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate
score: 1.2602797, Bioorganic & Medicinal Chemistry Letters, 2004, Maeda, Noriyuki et. al.
Studies on duocarmycin SA and its derivatives
score: 1.2601675, Bioorganic & Medicinal Chemistry, 1997, Nagamura, Satoru et. al.
In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues
score: 1.2600918, European Journal of Medicinal Chemistry, 2008, Liu, Ya-Nan et. al.
General strategy for the preparation of membrane permeable fluorogenic peptide ester conjugates for in vivo studies of ester prodrug stability
score: 1.2600293, Bioorganic & Medicinal Chemistry, 2004, Li, Xiaoxu; Taylor, John Stephen
Metalloantibodies: mercury(II)-dependent acyl transferases
score: 1.2599772, Bioorganic & Medicinal Chemistry, 2001, Brümmer, Oliver; Hoffman, Timothy Z; Janda, Kim D
Synthesis and properties of terthiophene-modified oligodeoxynucleotides
score: 1.2599498, Bioorganic & Medicinal Chemistry Letters, 2005, Kawai, Kiyohiko et. al.
A novel class of potent γ-aminobutyric acid aminotransferase inhibitor, 3-(hydroxyamino)propylamine and analogues
score: 1.2597708, Bioorganic & Medicinal Chemistry, 1997, Fushiya, Shinji; Kanazawa, Toshiyuki; Nozoe, Shigeo
Synthesis and properties of isocannabinoid and cholesterol derivatized rhamnosurfactants: application to liposomal targeting of keratinocytes and skin
score: 1.2597645, European Journal of Medicinal Chemistry, 2005, Barragan-Montero, Véronique et. al.
A new approach for PEGylation of dendrimers
score: 1.2596809, Bioorganic & Medicinal Chemistry Letters, 2010, Khambete, Hemant et. al.
In situ generated O-Glycan core 1 structure as substrate for Gal(β1–3)GalNAc β-1,6-GlcNAc Transferase
score: 1.2595927, Bioorganic & Medicinal Chemistry Letters, 1998, Dudziak, Gregor et. al.
Synthesis and structure–activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents
score: 1.2595866, Bioorganic & Medicinal Chemistry, 2005, Albrecht, Uwe; Lalk, Michael; Langer, Peter
Synthesis, ocular effects, and nitric oxide donation of imidazole amidoximes
score: 1.2595472, European Journal of Medicinal Chemistry, 2006, Oresmaa, L. et. al.
Antioxidant activity and cytoprotective effect of κ-carrageenan oligosaccharides and their different derivatives
score: 1.2595362, Bioorganic & Medicinal Chemistry Letters, 2006, Yuan, Huamao et. al.
Preparation and characterization of antioxidant nanospheres from multiple α-lipoic acid-containing compounds
score: 1.2593383, Bioorganic & Medicinal Chemistry Letters, 2009, Lee, Bong Seop et. al.
A Comparative Study of Backbone versus Side Chain Peptide Cyclization: Application for HIV-1 Integrase Inhibitors
score: 1.2593382, Bioorganic & Medicinal Chemistry, 2012, Hayouka, Zvi et. al.
Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agents
score: 1.2593054, Bioorganic & Medicinal Chemistry, 2005, Torti, Suzy V. et. al.
EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis.
score: 1.2591755, Antimicrobial agents and chemotherapy, 2002, Bellais, Samuel et. al.
Synthesis of new antimicrobial pyrrolo[2,1-a]isoquinolin-3-ones
score: 1.2591573, Bioorganic & Medicinal Chemistry, 2012, Moreno, Laura et. al.
Synthesis of new antimicrobial pyrrolo[2,1-a]isoquinolin-3-ones
score: 1.2591573, Bioorganic & Medicinal Chemistry, 2012, Moreno, Laura et. al.
Synthesis of new antimicrobial pyrrolo[2,1-a]isoquinolin-3-ones
score: 1.2591573, Bioorganic & Medicinal Chemistry, 2012, Moreno, Laura et. al.
Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa.
score: 1.2591221, Antimicrobial agents and chemotherapy, 1998, Li, X Z; Zhang, L; Srikumar, R; Poole, K
Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.
score: 1.2591054, Antimicrobial agents and chemotherapy, 2001, Entenza, J M et. al.
The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis.
score: 1.2589901, Antimicrobial agents and chemotherapy, 2000, Blanco, J et. al.
On the applicability of QSAR for recognition of miRNA bioorganic structures at early stages of organism and cell development: Embryo and stem cells
score: 1.2589808, Bioorganic & Medicinal Chemistry, 2007, González-Díaz, Humberto et. al.
Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond
score: 1.2589596, Bioorganic & Medicinal Chemistry Letters, 2012, Tanabe, Kazuhito; Asada, Takumi; Nishimoto, Sei-ichi
Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond
score: 1.2589596, Bioorganic & Medicinal Chemistry Letters, 2012, Tanabe, Kazuhito; Asada, Takumi; Nishimoto, Sei-ichi
Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond
score: 1.2589596, Bioorganic & Medicinal Chemistry Letters, 2012, Tanabe, Kazuhito; Asada, Takumi; Nishimoto, Sei-ichi
Synthesis and pharmacological studies at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring
score: 1.2589178, European Journal of Medicinal Chemistry, 2005, Calabri, Francesca Romana et. al.
Photo-Induced DNA cleavage reaction characteristics of propargylic sulfones possessing anthraquinone chromophore
score: 1.2589151, Bioorganic & Medicinal Chemistry, 2003, Haruna, Ken-ichi et. al.
New triorganotin(IV) derivatives of dipeptides as anti-inflammatory–antimicrobial agents
score: 1.2586692, European Journal of Medicinal Chemistry, 2005, Nath, Mala et. al.
Toward bifunctional antibody catalysis
score: 1.2586367, Bioorganic & Medicinal Chemistry, 2006, Kikuchi, Kazuya et. al.
Thionation of segetalins A and B, cyclic peptides with estrogen-like activity from seeds of Vaccaria segetalis
score: 1.258634, Bioorganic & Medicinal Chemistry, 1997, Morita, Hiroshi et. al.
Ex vivo drug susceptibility of ferroquine against chloroquine-resistant isolates of Plasmodium falciparum and P. vivax.
score: 1.258558, Antimicrobial agents and chemotherapy, 2011, Marfurt, Jutta et. al.
Validation of protein-based alignment in 3D quantitative structure–activity relationships with CoMFA models
score: 1.2585535, European Journal of Medicinal Chemistry, 2000, Golbraikh, Alexander et. al.
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1 H-triazoles
score: 1.2584673, Bioorganic & Medicinal Chemistry, 2006, Pautus, Stephane et. al.
Fluorescent Nitrile-Based Inhibitors of Cysteine Cathepsins
score: 1.2584665, Bioorganic & Medicinal Chemistry Letters, 2012, Frizler, Maxim; Mertens, Matthias D.; Gütschow, Michael
Polymer-Bound 1-Aryl-3-alkyltriazenes as Modular Ligands for Catalysis. Part 1: Synthesis and Metal Coordination
score: 1.2584319, Bioorganic & Medicinal Chemistry Letters, 2002, Bräse, Stefan et. al.
Structure-based rationalization of antitumor drugs mechanism of action by a MIF approach
score: 1.2583029, European Journal of Medicinal Chemistry, 2004, Cruciani, Gabriele et. al.
Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides
score: 1.2582946, Bioorganic & Medicinal Chemistry, 2005, Johar, Monika et. al.
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3- d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3- d]pyrimidin-5-ones
score: 1.2582883, Bioorganic & Medicinal Chemistry, 2006, Bruno, Olga et. al.
Exploring a possible way to synthesize novel better antioxidants based on vitamin E: A DFT study
score: 1.2582815, Bioorganic & Medicinal Chemistry Letters, 2006, Chen, Weijun; Song, Jirong; Guo, Ping; Cao, Wei; Bian, Jiang
Molecular and biochemical analysis of AST-1, a class A beta-lactamase from Nocardia asteroides sensu stricto.
score: 1.2582299, Antimicrobial agents and chemotherapy, 2001, Poirel, L et. al.
Activity of pyocin S2 against Pseudomonas aeruginosa biofilms.
score: 1.2580746, Antimicrobial agents and chemotherapy, 2012, Smith, Karen et. al.
One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases
score: 1.258037, Bioorganic & Medicinal Chemistry Letters, 2009, Melançon, Charles E.; Schultz, Peter G.
Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones.
score: 1.2579866, Antimicrobial agents and chemotherapy, 2006, Strahilevitz, Jacob; Robicsek, Ari; Hooper, David C
New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues
score: 1.2579743, Bioorganic & Medicinal Chemistry, 2001, Kasai, Soko et. al.
Lack of relationship between purine biosynthesis and vancomycin resistance in Staphylococcus aureus: a cautionary tale for microarray interpretation.
score: 1.2578652, Antimicrobial agents and chemotherapy, 2007, Fox, Paige M; Climo, Michael W; Archer, Gordon L
2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges
score: 1.2578309, Bioorganic & Medicinal Chemistry Letters, 2004, Kobori, Akio et. al.
Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: Clinical compound TD-2749
score: 1.257785, Bioorganic & Medicinal Chemistry Letters, 2012, Long, Daniel D. et. al.
Discovery, Oral Pharmacokinetics and In Vivo Efficacy of a Highly Selective 5-HT4 Receptor Agonist: Clinical Compound TD-2749
score: 1.257785, Bioorganic & Medicinal Chemistry Letters, 2012, Long, Daniel D. et. al.
Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: Clinical compound TD-2749
score: 1.257785, Bioorganic & Medicinal Chemistry Letters, 2012, Long, Daniel D. et. al.
Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: Clinical compound TD-2749
score: 1.257785, Bioorganic & Medicinal Chemistry Letters, 2012, Long, Daniel D. et. al.
Antimicrobial susceptibility of Streptococcus pneumoniae in eight European countries from 2001 to 2003.
score: 1.2576819, Antimicrobial agents and chemotherapy, 2005, Reinert, Ralf René et. al.
Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: molecular modeling study
score: 1.2576791, Bioorganic & Medicinal Chemistry, 2005, Goda, Fatma E.; Abdel-Aziz, Alaa A.-M.; Ghoneim, Hamdy A.
PEGylated liposome encapsulation increases the lung tissue concentration of vancomycin.
score: 1.2575956, Antimicrobial agents and chemotherapy, 2011, Muppidi, Krishna et. al.
Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes
score: 1.2575428, Bioorganic & Medicinal Chemistry, 2000, Tsukamoto, Yoshihisa; Cole, Loretta M.; Casida, John E.
Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors
score: 1.2575342, Bioorganic & Medicinal Chemistry, 2012, Poongavanam, Vasanthanathan et. al.
Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors
score: 1.2575342, Bioorganic & Medicinal Chemistry, 2012, Poongavanam, Vasanthanathan et. al.
Interrupted time series analysis of vancomycin compared to cefuroxime for surgical prophylaxis in patients undergoing cardiac surgery.
score: 1.257517, Antimicrobial agents and chemotherapy, 2008, Garey, K W et. al.
Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates.
score: 1.2573021, Antimicrobial agents and chemotherapy, 2012, Balganesh, Meenakshi et. al.
Tuberculosis and trimethoprim-sulfamethoxazole.
score: 1.2572351, Antimicrobial agents and chemotherapy, 2009, Forgacs, Pierre et. al.
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
score: 1.2572242, European Journal of Medicinal Chemistry, 2012, Altıntop, Mehlika Dilek et. al.
First description of KPC-2-producing Pseudomonas putida in Brazil.
score: 1.2572202, Antimicrobial agents and chemotherapy, 2012, Almeida, Anna C S et. al.
Positioning of the Carboxamide Side Chain in 11-Oxo-11 H-indeno[1,2- b]quinolinecarboxamide Anticancer Agents: Effects on Cytotoxicity
score: 1.2570405, Bioorganic & Medicinal Chemistry, 2001, Deady, Leslie W. et. al.
Photoreactivities of 5-Bromouracil-containing RNAs
score: 1.2568239, Bioorganic & Medicinal Chemistry, 2013, Morinaga, Hironobu et. al.
Rational drug design for anti-cancer chemotherapy: Multi-target QSAR models for the in silico discovery of anti-colorectal cancer agents
score: 1.256809, Bioorganic & Medicinal Chemistry, 2012, Speck-Planche, Alejandro et. al.
Study on anti-proliferative effect of benzoxathiole derivatives through inactivation of NF-κB in human cancer cells
score: 1.2567985, Bioorganic & Medicinal Chemistry Letters, 2012, Venkateswararao, Eeda et. al.
Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: Synthesis, characterization, and their interaction with plasmid DNA
score: 1.2567783, Bioorganic & Medicinal Chemistry, 2006, Li, Qiang-Lin et. al.
Synthesis and cardiovascular activity of metoprolol analogues
score: 1.2567515, Bioorganic & Medicinal Chemistry Letters, 2004, Melgar-Fernández, Roberto et. al.
Convenient synthesis of human calcitonin and its methionine sulfoxide derivative
score: 1.2566416, Bioorganic & Medicinal Chemistry Letters, 2002, Shi, Tiesheng; Rabenstein, Dallas L
Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B
score: 1.2565205, Bioorganic & Medicinal Chemistry Letters, 2013, Tanaka, Yuka Tsuda et. al.
Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay.
score: 1.2564585, Antimicrobial agents and chemotherapy, 2005, O'Boyle, Donald R et. al.
Comparison of the performances of two in-house rapid methods for antitubercular drug susceptibility testing.
score: 1.256386, Antimicrobial agents and chemotherapy, 2009, de la Iglesia, Agustina I et. al.
Regulation of membrane permeability by a two-component regulatory system in Pseudomonas aeruginosa.
score: 1.2563347, Antimicrobial agents and chemotherapy, 2003, Wang, Yanping; Ha, Unhwan; Zeng, Lin; Jin, Shouguang
Design, synthesis and peroxidase-like activity of 3α-helix proteins covalently bound to heme
score: 1.2563313, Bioorganic & Medicinal Chemistry Letters, 2000, Obataya, Ikuo et. al.
Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives
score: 1.2562675, European Journal of Medicinal Chemistry, 2012, Garudachari, B. et. al.
Synthesis and evaluation of glycosidase inhibitory activity of N-butyl 1-deoxy- d- gluco-homonojirimycin and N-butyl 1-deoxy- l- ido-homonojirimycin
score: 1.2562419, Bioorganic & Medicinal Chemistry, 2006, Markad, Shankar D. et. al.
Hydrophobic forms of morphine-6-glucosides
score: 1.256188, Bioorganic & Medicinal Chemistry Letters, 2001, Schwarzinger, Stephan et. al.
Turn-on fluorescent probe with visible light excitation for labeling of hexahistidine tagged protein
score: 1.2561721, Bioorganic & Medicinal Chemistry Letters, 2009, Kamoto, Mie et. al.
Synthesis and activity of N-Benzyl pseudopeptides HIV protease inhibitors
score: 1.2561246, Bioorganic & Medicinal Chemistry, 2003, Marastoni, Mauro et. al.
Ligand design for α 1 adrenoceptor subtype selective antagonists
score: 1.2560588, Bioorganic & Medicinal Chemistry, 2000, Bremner, John B et. al.
Combinatorial synthesis of libraries of indole derivatives
score: 1.2560405, Bioorganic & Medicinal Chemistry Letters, 2001, Nettekoven, Matthias
Symmetry requirements for effective blocking of pore-forming toxins: comparative study with alpha-, beta-, and gamma-cyclodextrin derivatives.
score: 1.2559668, Antimicrobial agents and chemotherapy, 2011, Yannakopoulou, Konstantina et. al.
Liposome-Mediated Delivery of Iminosugars Enhances Efficacy against Dengue Virus In Vivo.
score: 1.2558737, Antimicrobial agents and chemotherapy, 2012, Miller, Joanna L et. al.
Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE)
score: 1.2558507, Bioorganic & Medicinal Chemistry, 2006, Parkkari, Teija et. al.
Sterilizing Activity of Novel TMC207- and PA-824-Containing Regimens in a Murine Model of Tuberculosis.
score: 1.2557403, Antimicrobial agents and chemotherapy, 2011, Tasneen, Rokeya et. al.
Effects of intratracheal administration of novispirin G10 on a rat model of mucoid Pseudomonas aeruginosa lung infection.
score: 1.255635, Antimicrobial agents and chemotherapy, 2005, Song, Zhijun et. al.
Dual 5-HT 1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity
score: 1.2556158, Bioorganic & Medicinal Chemistry, 2004, Heinrich, Timo et. al.
TEM-89 beta-lactamase produced by a Proteus mirabilis clinical isolate: new complex mutant (CMT 3) with mutations in both TEM-59 (IRT-17) and TEM-3.
score: 1.2554797, Antimicrobial agents and chemotherapy, 2001, Neuwirth, C et. al.
Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β, d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH 2) and its Gd(III) complex
score: 1.2554598, Bioorganic & Medicinal Chemistry, 2007, Wardle, Nick J. et. al.
Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions.
score: 1.2553594, Antimicrobial agents and chemotherapy, 2006, Rydlo, Tali; Rotem, Shahar; Mor, Amram
Efficacy of zidovudine compared to stavudine, both in combination with lamivudine and indinavir, in human immunodeficiency virus-infected nucleoside-experienced patients with no prior exposure to lamivudine, stavudine, or protease inhibitors (novavir trial).
score: 1.2553496, Antimicrobial agents and chemotherapy, 2002, Joly, Véronique et. al.
A PNA–DNA hybridization chip approach for the detection of β-secretase activity
score: 1.2553115, Bioorganic & Medicinal Chemistry Letters, 2006, Sano, Shusuke et. al.
Double-stranded oligonucleotides containing 5-aminomethyl-2′-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA
score: 1.2552859, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Aya et. al.
Double-stranded oligonucleotides containing 5-aminomethyl-2′-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA
score: 1.2552859, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Aya et. al.
Coupling of receptor conformation and ligand orientation determine graded activity.
score: 1.2552748, Nature chemical biology, 2010, Bruning, John B et. al.
Synthesis and hybridization properties of oligonucleotides containing 6-membered azasugar nucleotides
score: 1.2549342, Bioorganic & Medicinal Chemistry Letters, 1999, Jung, Kyeong-Eun et. al.
Enzymatic synthesis of perfluoroalkylated DNA
score: 1.2547133, Bioorganic & Medicinal Chemistry, 2009, Holzberger, Bastian; Marx, Andreas
In vitro activity of gemifloxacin (SB-265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea pigs with L. pneumophila pneumonia.
score: 1.2546539, Antimicrobial agents and chemotherapy, 2001, Edelstein, P H; Shinzato, T; Doyle, E; Edelstein, M A
pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines.
score: 1.2546261, Antimicrobial agents and chemotherapy, 2003, Chen, Nanhua et. al.
O 6-3-[ 125I]iodobenzyl-2′-deoxyguanosine ([ 125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT)
score: 1.254605, Bioorganic & Medicinal Chemistry, 2005, Shankar, Sriram; Zalutsky, Michael R.; Vaidyanathan, Ganesan
Intrinsic factor-mediated modulation of cyanocobalamin– N-sulfonyl-acridinium-9-carboxamide chemiluminescence
score: 1.2545088, Bioorganic & Medicinal Chemistry Letters, 2004, Adamczyk, Maciej et. al.
Thrombomodulin induction in cultured human endothelial cells by 9- cis-locked retinoic acid analogues
score: 1.2544598, Bioorganic & Medicinal Chemistry, 2006, Ikegami, Shiro et. al.
Supramolecular energy transfer from photoexcited chlorosomal zinc porphyrin self-aggregates to a chlorin or bacteriochlorin monomer as models of main light-harvesting antenna systems in green photosynthetic bacteria
score: 1.2543609, Bioorganic & Medicinal Chemistry Letters, 2012, Kataoka, Yumiko; Shibata, Yutaka; Tamiaki, Hitoshi
Comparative efficacies of quinupristin-dalfopristin, linezolid, vancomycin, and ciprofloxacin in treatment, using the antibiotic-lock technique, of experimental catheter-related infection due to Staphylococcus aureus.
score: 1.2543529, Antimicrobial agents and chemotherapy, 2005, Giacometti, Andrea et. al.
High-dose isoniazid therapy for isoniazid-resistant murine Mycobacterium tuberculosis infection.
score: 1.2543527, Antimicrobial agents and chemotherapy, 1999, Cynamon, M H et. al.
QSAR analysis of salicylamide isosteres with the use of quantum chemical molecular descriptors
score: 1.2543161, European Journal of Medicinal Chemistry, 2009, Doležal, R.; Van Damme, S.; Bultinck, P.; Waisser, K.
Spironolactone-related inhibitors of type II 17β-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities
score: 1.2542587, Bioorganic & Medicinal Chemistry, 1999, Tremblay, Martin R. et. al.
A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6
score: 1.2542354, Bioorganic & Medicinal Chemistry Letters, 2012, Todoroki, Yasushi et. al.
A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6
score: 1.2542354, Bioorganic & Medicinal Chemistry Letters, 2012, Todoroki, Yasushi et. al.
Facile synthesis of the heptasaccharide repeating unit of O-deacetylated GXM of C. neoformans serotype B
score: 1.2540964, Bioorganic & Medicinal Chemistry, 2005, Zhao, Wei; Kong, Fanzuo
Reversal of optical induction in transamination by regioisomeric bifunctionalized cyclodextrins 1 This paper is dedicated to the memory of Derek Barton, an extraordinary chemist and role model. 1
score: 1.2539843, Bioorganic & Medicinal Chemistry, 1999, Fasella, Elisabetta; Dong, Steven D.; Breslow, Ronald
Azasordarins: susceptibility of fluconazole-susceptible and fluconazole-resistant clinical isolates of Candida spp. to GW 471558.
score: 1.2539482, Antimicrobial agents and chemotherapy, 2001, Cuenca-Estrella, M et. al.
Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch
score: 1.2538745, Bioorganic & Medicinal Chemistry Letters, 2000, Sørensen, Mads D et. al.
High incorporation of l-amino acids to cereulide, an emetic toxin from Bacillus cereus
score: 1.2538298, Bioorganic & Medicinal Chemistry Letters, 2000, Kuse, Masaki et. al.
Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates
score: 1.2538138, Bioorganic & Medicinal Chemistry, 2003, Dei, Silvia et. al.
Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.
score: 1.2537083, Antimicrobial agents and chemotherapy, 1998, Mendel, D B et. al.
Glycidol-carbohydrate hybrids: a new family of DNA alkylating agents
score: 1.2536233, Bioorganic & Medicinal Chemistry Letters, 2003, Toshima, Kazunobu; Okuno, Yukiko; Matsumura, Shuichi
Designed calix[8]arene-based ligands for selective tryptase surface recognition
score: 1.2535727, Bioorganic & Medicinal Chemistry, 2004, Mecca, Tommaso et. al.
Comparative In Vitro and In Vivo Efficacies of Human Simulated Doses of Ceftazidime and Ceftazidime-Avibactam against Pseudomonas aeruginosa.
score: 1.2535509, Antimicrobial agents and chemotherapy, 2012, Crandon, Jared L et. al.
Hydroxyl radical-induced cross-linking of thymine and lysine: Identification of the primary structure and mechanism
score: 1.2535035, Bioorganic & Medicinal Chemistry Letters, 1998, Morimoto, Syota et. al.
6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D 4 receptors
score: 1.2534981, Bioorganic & Medicinal Chemistry, 2001, Hodgetts, Kevin J et. al.
Occurrence of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae in Italy: implications for resistance to beta-lactams and other antimicrobial drugs.
score: 1.2534332, Antimicrobial agents and chemotherapy, 2002, Spanu, T et. al.
Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains
score: 1.2534315, Bioorganic & Medicinal Chemistry, 1999, Buijsman, Rogier C. et. al.
DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modifications
score: 1.2534315, Bioorganic & Medicinal Chemistry Letters, 2010, Kawai, Kazuaki; Li, Yun-Shan; Song, Ming-Fen; Kasai, Hiroshi
Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate
score: 1.2533627, Bioorganic & Medicinal Chemistry, 2008, Niitsu, Ai et. al.
Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus.
score: 1.2533537, Antimicrobial agents and chemotherapy, 2006, Friedman, Lisa; Alder, Jeff D; Silverman, Jared A
Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CL pro: Structure–activity relationship studies reveal salient pharmacophore features
score: 1.2532816, Bioorganic & Medicinal Chemistry, 2006, Chen, Lili et. al.
Ethidium bromide MIC screening for enhanced efflux pump gene expression or efflux activity in Staphylococcus aureus.
score: 1.2532581, Antimicrobial agents and chemotherapy, 2010, Patel, Diixa et. al.
Phenolic Modification as an Approach to Improve the Pharmacology of the 3-Acyloxy-2-benzylpropyl Homovanillic Amides and Thioureas, a Promising Class of Vanilloid Receptor Agonists and Analgesics
score: 1.2532525, Bioorganic & Medicinal Chemistry, 2002, Lee, Jeewoo et. al.
Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: Synthesis of N-acyl glycinals
score: 1.2530975, Bioorganic & Medicinal Chemistry Letters, 2009, Aneetha, Halikhedkar et. al.
Detection of structure-switching in G-quadruplexes using end-stacking ability
score: 1.2530953, Bioorganic & Medicinal Chemistry Letters, 2008, Seo, Young Jun; Lee, Il Joon; Kim, Byeang Hyean
Excretion of moxidectin into breast milk and pharmacokinetics in healthy lactating women.
score: 1.2530392, Antimicrobial agents and chemotherapy, 2011, Korth-Bradley, Joan M et. al.
Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture
score: 1.2530198, Bioorganic & Medicinal Chemistry Letters, 2012, Hirayama, Tasuku et. al.
Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture
score: 1.2530198, Bioorganic & Medicinal Chemistry Letters, 2012, Hirayama, Tasuku et. al.
Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture
score: 1.2530198, Bioorganic & Medicinal Chemistry Letters, 2012, Hirayama, Tasuku et. al.
Novel concentration-killing curve method for estimation of bactericidal potency of antibiotics in an in vitro dynamic model.
score: 1.2529533, Antimicrobial agents and chemotherapy, 2004, Liu, Y Q; Zhang, Y Z; Gao, P J
Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria.
score: 1.2529064, Antimicrobial agents and chemotherapy, 2008, Brown, Mindy G; Mitchell, Elizabeth H; Balkwill, David L
Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria.
score: 1.2528371, Antimicrobial agents and chemotherapy, 2000, Pukrittayakamee, S et. al.
Stochastic searches and NMR experiments on four Lewis A analogues: NMR experiments support some flexibility around the fucosidic bond
score: 1.2528359, Bioorganic & Medicinal Chemistry, 2012, Auzanneau, France-Isabelle; Jackson, Trudy A.; Liao, Liang
Evaluation of dimerization–inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor
score: 1.2527275, Bioorganic & Medicinal Chemistry, 2012, Mizuguchi, Takaaki et. al.
Activities of newer fluoroquinolones against Streptococcus pneumoniae clinical isolates including those with mutations in the gyrA, parC, and parE loci.
score: 1.2527102, Antimicrobial agents and chemotherapy, 1999, Jorgensen, J H et. al.
Directed HIV-1 Evolution of Protease Inhibitor Resistance by Second-Generation Short Hairpin RNAs.
score: 1.2526582, Antimicrobial agents and chemotherapy, 2012, Schopman, Nick C T; Braun, Anja; Berkhout, Ben
In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides.
score: 1.2526421, Antimicrobial agents and chemotherapy, 2004, Van Herrewege, Yven et. al.
Isolation of antibiotic hypersusceptibility mutants of Acinetobacter spp. by selection for DNA release.
score: 1.2525622, Antimicrobial agents and chemotherapy, 2003, Lee, Hyunwoo et. al.
New dirhodium complex with activity towards colorectal cancer
score: 1.2525462, Bioorganic & Medicinal Chemistry Letters, 2010, Frade, Raquel F.M. et. al.
The oxidation of 8-oxo-7,8-dihydroguanine by iodine
score: 1.2523593, Bioorganic & Medicinal Chemistry Letters, 2010, Kino, Katsuhito et. al.
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine
score: 1.2522602, Bioorganic & Medicinal Chemistry, 2000, Shimma, Nobuo et. al.
Discrepancy between uptake and intracellular activity of moxifloxacin in a Staphylococcus aureus-human THP-1 monocytic cell model.
score: 1.2522223, Antimicrobial agents and chemotherapy, 2002, Paillard, Delphine et. al.
Cytotoxic versus anti-inflammatory effects in HeLa, jurkat t and human peripheral blood cells caused by guaianolide-Type sesquiterpene lactones
score: 1.2522043, Bioorganic & Medicinal Chemistry, 2003, Hilmi, Fatima et. al.
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring
score: 1.2522015, European Journal of Medicinal Chemistry, 2012, Mohammed Iqbal, A.K. et. al.
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring
score: 1.2522015, European Journal of Medicinal Chemistry, 2012, Mohammed Iqbal, A.K. et. al.
N-Thiolated β-Lactams: novel antibacterial agents for methicillin-Resistant Staphylococcus aureus
score: 1.2521654, Bioorganic & Medicinal Chemistry Letters, 2002, Turos, Edward et. al.
A thiophosphate analog of dimyristoylphosphatidyl-inositol-4-phosphate is a substrate for mammalian phosphoinositide-specific phospholipase c
score: 1.2521099, Bioorganic & Medicinal Chemistry Letters, 1998, Hendrickson, H.Stewart; Hendrickson, Elizabeth K.
Synthesis and metabolism of naphthyl substituted phosphoramidate derivatives of stavudine
score: 1.2519697, Bioorganic & Medicinal Chemistry, 2006, Venkatachalam, T.K.; Qazi, S.; Uckun, F.M.
One-pot synthesis of 3,4-dihydropyrimidin-2(1 H)-ones using chloroacetic acid as catalyst
score: 1.2519636, Bioorganic & Medicinal Chemistry Letters, 2007, Yu, Yang; Liu, Di; Liu, Chunsheng; Luo, Genxiang
Application of genetic algorithm-kernel partial least square as a novel nonlinear feature selection method: Activity of carbonic anhydrase II inhibitors
score: 1.251907, European Journal of Medicinal Chemistry, 2007, Jalali-Heravi, Mehdi; Kyani, Anahita
Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide.
score: 1.2518853, Antimicrobial agents and chemotherapy, 2005, Andersson, Elin et. al.
Antifungal peptides: novel therapeutic compounds against emerging pathogens.
score: 1.2518629, Antimicrobial agents and chemotherapy, 1999, De Lucca, A J; Walsh, T J
Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium
score: 1.251852, Bioorganic & Medicinal Chemistry Letters, 1999, Jiang, Zhi-Dong; Jensen, Paul R.; Fenical, William
Stereoselective synthesis of dinucleoside boranophosphates by an oxazaphospholidine method
score: 1.2518175, Bioorganic & Medicinal Chemistry Letters, 2006, Wada, Takeshi et. al.
Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation
score: 1.251806, Bioorganic & Medicinal Chemistry, 2002, Shim, Joong Sup et. al.
Synthesis and evaluation of N-(5-fluoro-2-phenoxyphenyl)- N-(2-[ 18F]fluoromethoxy- d 2-5-methoxybenzyl)acetamide: a deuterium-substituted radioligand for peripheral benzodiazepine receptor
score: 1.2517957, Bioorganic & Medicinal Chemistry, 2005, Zhang, Ming-Rong et. al.
4-Hydroxymethyl- and 4-methoxymethylfuro[2,3- h]quinolin-2(1 H)-ones: synthesis and biological properties
score: 1.251717, Bioorganic & Medicinal Chemistry, 2003, Chilin, Adriana et. al.
Synthesis and β-blocking activity of ( R, S)-( E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3- b]pyridine: identification of β 3-antagonists
score: 1.2515805, Bioorganic & Medicinal Chemistry, 2003, Saccomanni, Giuseppe et. al.
QSAR models based on quantum topological molecular similarity
score: 1.2515764, European Journal of Medicinal Chemistry, 2006, Popelier, P.L.A.; Smith, P.J.
Mixed-Backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects
score: 1.2515651, Bioorganic & Medicinal Chemistry Letters, 1998, Zhou, Wenqiang; Agrawal, Sudhir
Napthalimidobenzamide DB-51630: a novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activity
score: 1.2514293, Bioorganic & Medicinal Chemistry, 2005, Suzuki, Kenji et. al.
A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6
score: 1.2514028, Bioorganic & Medicinal Chemistry Letters, 2012, Todoroki, Yasushi et. al.
Non-conventional hydrolase chemistry: amide and carbamate bond formation catalyzed by lipases
score: 1.251346, Bioorganic & Medicinal Chemistry, 1999, Gotor, Vicente
4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity
score: 1.251329, Bioorganic & Medicinal Chemistry, 2005, Sparatore, Anna et. al.
The solid-phase conjugation of purpurin-18 with a synthetic targeting peptide
score: 1.2513283, Bioorganic & Medicinal Chemistry Letters, 2004, Walker, Ian; Vernon, David I.; Brown, Stanley B.
Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets
score: 1.2512919, Bioorganic & Medicinal Chemistry, 2000, Chen, I-Jen et. al.
Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives
score: 1.2512175, Bioorganic & Medicinal Chemistry, 2002, Madhavan, Gurram R et. al.
Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells
score: 1.2511304, Bioorganic & Medicinal Chemistry Letters, 2010, Tsumoto, Hiroki et. al.
Identification of N 2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product
score: 1.2511068, Bioorganic & Medicinal Chemistry Letters, 1998, Al-Abed, Yousef et. al.
Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus.
score: 1.2510997, Antimicrobial agents and chemotherapy, 2002, Hu, Zhi-Qing et. al.
Design, synthesis, and evaluation of a novel class of 2,3-disubstituted-tetrahydro-β-carboline derivatives
score: 1.2504779, Bioorganic & Medicinal Chemistry Letters, 2012, Zeng, Li; Zhang, Jianwei
Synthesis and neuromuscular blocking activity of 16β- N-methylpiperazino steroidal derivatives
score: 1.2503779, European Journal of Medicinal Chemistry, 2002, Jindal, Dharam Paul et. al.
1,4,9,10-Anthradiquinone as precursor for antitumor compounds
score: 1.2501817, Bioorganic & Medicinal Chemistry, 2006, Schenck, Lothar Werner et. al.
DNA Alkylation by leinamycin can be triggered by cyanide and phosphines
score: 1.2500555, Bioorganic & Medicinal Chemistry Letters, 2001, Zang, Hong et. al.
Chromosome-encoded extended-spectrum class A β-lactamase MIN-1 from Minibacterium massiliensis.
score: 1.2499623, Antimicrobial agents and chemotherapy, 2012, Bercot, Béatrice et. al.
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
score: 1.2498897, Antimicrobial agents and chemotherapy, 2000, Hostetler, K Y et. al.
Comparative genome sequencing of an isogenic pair of USA800 clinical methicillin-resistant Staphylococcus aureus isolates obtained before and after daptomycin treatment failure.
score: 1.249855, Antimicrobial agents and chemotherapy, 2011, Boyle-Vavra, Susan et. al.
Peptidomimetic Glutathione Analogues as Novel γGT Stable GST Inhibitors
score: 1.2498273, Bioorganic & Medicinal Chemistry, 2002, Burg, Danny et. al.
Synthesis of sphingomyelin sulfur analogue and its behavior toward sphingomyelinase
score: 1.2497872, Bioorganic & Medicinal Chemistry Letters, 2005, Hakogi, Toshikazu et. al.
Polymer-bound reagents for the introduction of spacer-modified biotin labels
score: 1.2497377, Bioorganic & Medicinal Chemistry, 2004, Herforth, Claudia et. al.
Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety
score: 1.2497287, Bioorganic & Medicinal Chemistry, 2006, Karthikeyan, Mari Sithambaram et. al.
Novel streptomycin and spectinomycin resistance gene as a gene cassette within a class 1 integron isolated from Escherichia coli.
score: 1.249712, Antimicrobial agents and chemotherapy, 1999, Sandvang, D
Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalcanones
score: 1.2495507, European Journal of Medicinal Chemistry, 2005, Charris, Jaime E. et. al.
Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases
score: 1.2495464, Bioorganic & Medicinal Chemistry, 1999, Lee, Younghee et. al.
Fluorinated quinoid inhibitor: possible `pure' arylator predicted by the simple theoretical calculation
score: 1.249418, Bioorganic & Medicinal Chemistry Letters, 2004, Wook Ham, Seung et. al.
Neopeptide antibiotics that function as opsonins and membrane-permeabilizing agents for gram-negative bacteria.
score: 1.2494084, Antimicrobial agents and chemotherapy, 2005, Tsubery, Haim et. al.
Synthesis and characterization of copper(II) and zinc(II)-based potential chemotherapeutic compounds: Their biological evaluation viz. DNA binding profile, cleavage and antimicrobial activity
score: 1.2493931, European Journal of Medicinal Chemistry, 2012, Tabassum, Sartaj et. al.
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases
score: 1.2491281, Bioorganic & Medicinal Chemistry, 2006, Darvesh, Sultan et. al.
Receptor-binding studies of 1-N-substituted melatonin analogues
score: 1.2489918, European Journal of Medicinal Chemistry, 2002, Lira-Rocha, Alfonso et. al.
In vitro synergy of daptomycin plus rifampin against Enterococcus faecium resistant to both linezolid and vancomycin.
score: 1.2489616, Antimicrobial agents and chemotherapy, 2005, Pankey, George; Ashcraft, Deborah; Patel, Nalini
Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias
score: 1.2489586, Bioorganic & Medicinal Chemistry, 2004, Koufaki, Maria et. al.
Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug.
score: 1.2488944, Antimicrobial agents and chemotherapy, 2003, Pérez-Victoria, F Javier et. al.
8–17 DNAzyme modified with purine analogs in its catalytic core: The conservation of the five-membered moieties of purine residues
score: 1.2488406, Bioorganic & Medicinal Chemistry Letters, 2012, Rong, Wei et. al.
Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2
score: 1.2487629, Bioorganic & Medicinal Chemistry Letters, 2006, Moffet, David A.; Khosla, Chaitan; Cane, David E.
Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines
score: 1.248741, Bioorganic & Medicinal Chemistry, 2003, Kawanaka, Yasufumi et. al.
Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase.
score: 1.2487407, Antimicrobial agents and chemotherapy, 2000, Ma, L; Kovacs, J A
N-Aroyloxylthioxo-naphthalimides as DNA photocleavers of aroyloxyl oxygen radicals: synthesis, evaluation, and substituents’ effect
score: 1.2487285, Bioorganic & Medicinal Chemistry, 2004, Xu, Yufang; Huang, Xiayu; Qian, Xuhong; Yao, Wei
Activity of Gallidermin on Staphylococcus aureus and Staphylococcus epidermidis Biofilms.
score: 1.2486773, Antimicrobial agents and chemotherapy, 2012, Saising, Jongkon et. al.
Free energy calculations on the binding of novel thiolactomycin derivatives to E. coli fatty acid synthase I
score: 1.2485965, Bioorganic & Medicinal Chemistry, 2012, Steinbrecher, Thomas; Case, David A.; Labahn, Andreas
Free energy calculations on the binding of novel thiolactomycin derivatives to E. coli fatty acid synthase I
score: 1.2485965, Bioorganic & Medicinal Chemistry, 2012, Steinbrecher, Thomas; Case, David A.; Labahn, Andreas
Free energy calculations on the binding of novel thiolactomycin derivatives to E. coli fatty acid synthase I
score: 1.2485965, Bioorganic & Medicinal Chemistry, 2012, Steinbrecher, Thomas; Case, David A.; Labahn, Andreas
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists
score: 1.2485203, Bioorganic & Medicinal Chemistry Letters, 2012, Éles, János et. al.
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists
score: 1.2485203, Bioorganic & Medicinal Chemistry Letters, 2012, Éles, János et. al.
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists
score: 1.2485203, Bioorganic & Medicinal Chemistry Letters, 2012, Éles, János et. al.
Eudistomidin G, a new β-carboline alkaloid from the Okinawan marine tunicate Eudistoma glaucus and structure revision of eudistomidin B
score: 1.2485132, Bioorganic & Medicinal Chemistry Letters, 2010, Takahashi, Yohei et. al.
MICs of mutacin B-Ny266, nisin A, vancomycin, and oxacillin against bacterial pathogens.
score: 1.2485042, Antimicrobial agents and chemotherapy, 2000, Mota-Meira, M; LaPointe, G; Lacroix, C; Lavoie, M C
Effect of telithromycin (HMR 3647) on polymorphonuclear neutrophil killing of Staphylococcus aureus in comparison with roxithromycin.
score: 1.2484623, Antimicrobial agents and chemotherapy, 2002, Vazifeh, D; Abdelghaffar, H; Labro, M T
Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents 1
score: 1.2484388, Bioorganic & Medicinal Chemistry, 2000, Batra, Sanjay et. al.
Solution structural investigation and conformation–activity relationship of BAM8-22 by NMR and molecular dynamics simulations
score: 1.2484114, Bioorganic & Medicinal Chemistry Letters, 2010, Lv, Guohua; Dong, Shouliang
Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States.
score: 1.248363, Antimicrobial agents and chemotherapy, 2004, Alvarez, M; Tran, J H; Chow, N; Jacoby, G A
A practical and green approach toward synthesis of N3-substituted dihydropyrimidinones: Using Aza-Michael addition reaction catalyzed by KF/Al 2O 3
score: 1.2483463, Bioorganic & Medicinal Chemistry Letters, 2006, Wang, Xicun et. al.
Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.
score: 1.2482196, Antimicrobial agents and chemotherapy, 1998, Nzila-Mounda, A et. al.
QSAR models of quail dietary toxicity based on the graph of atomic orbitals
score: 1.2480946, Bioorganic & Medicinal Chemistry Letters, 2006, Toropov, Andrey A.; Benfenati, Emilio
Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp.
score: 1.2479943, Antimicrobial agents and chemotherapy, 2006, Eckert, Randal et. al.
Amygdalin binds to the CD4 receptor as suggested from molecular modeling studies
score: 1.2479523, Bioorganic & Medicinal Chemistry Letters, 1998, Llorens, Oriol et. al.
PET imaging and optical imaging with d-luciferin [ 11C]methyl ester and d-luciferin [ 11C]methyl ether of luciferase gene expression in tumor xenografts of living mice
score: 1.2479416, Bioorganic & Medicinal Chemistry Letters, 2006, Wang, Ji-Quan et. al.
Red fluorescent scaffold for highly sensitive protease activity probes
score: 1.2479306, Bioorganic & Medicinal Chemistry Letters, 2012, Kushida, Yu et. al.
Red fluorescent scaffold for highly sensitive protease activity probes
score: 1.2479306, Bioorganic & Medicinal Chemistry Letters, 2012, Kushida, Yu et. al.
Red fluorescent scaffold for highly sensitive protease activity probes
score: 1.2479306, Bioorganic & Medicinal Chemistry Letters, 2012, Kushida, Yu et. al.
1,4-Benzothiazine and 1,4-Benzoxazine imidazole derivatives with antifungal activity: A docking study
score: 1.2477715, Bioorganic & Medicinal Chemistry, 2002, Macchiarulo, Antonio et. al.
Highly efficient synthesis of vinyl substituted triazoles by Au(I) catalyzed alkyne activation
score: 1.2477422, Bioorganic & Medicinal Chemistry Letters, 2009, Duan, Haifeng; Yan, Wuming; Sengupta, Sujata; Shi, Xiaodong
Synthesis and anti-viral activity of a series of d- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system
score: 1.2477405, Bioorganic & Medicinal Chemistry, 2005, Shi, Junxing et. al.
Biological activity evaluation and structure–activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer
score: 1.2477321, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Weixia et. al.
Nickel(II) 2,6-diacetylpyridine bis(isonicotinoylhydrazonate) and bis(benzoylhydrazonate) complexes: structure and antimycobacterial evaluation. Part XI
score: 1.2476444, Bioorganic & Medicinal Chemistry, 2001, Bottari, B. et. al.
Once-daily oral gatifloxacin versus oral levofloxacin in treatment of uncomplicated skin and soft tissue infections: double-blind, multicenter, randomized study.
score: 1.2475229, Antimicrobial agents and chemotherapy, 2001, Tarshis, G A et. al.
AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis.
score: 1.2474965, Antimicrobial agents and chemotherapy, 2003, Visalli, Melissa A et. al.
New quinoxaline 1,4-di- N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di- N-oxides
score: 1.2474356, Bioorganic & Medicinal Chemistry, 2006, Amin, Kamelia M. et. al.
Unambiguous structure of atractyloside and carboxyatractyloside
score: 1.24739, Bioorganic & Medicinal Chemistry Letters, 2012, Sanchez, Jean-Frédéric et. al.
Study on the mechanism of action of artemether against schistosomes: the identification of cysteine adducts of both carbon-centred free radicals derived from artemether
score: 1.2473405, Bioorganic & Medicinal Chemistry Letters, 2003, Wu, Wen-Min et. al.
Efficient approach for profiling photoaffinity labeled peptides with a cleavable biotinyl photoprobe
score: 1.2472256, Bioorganic & Medicinal Chemistry Letters, 2010, Bongo, Nlandu B.; Tomohiro, Takenori; Hatanaka, Yasumaru
Applying new diagnostic criteria for acute kidney injury to facilitate early identification of nephrotoxicity in vancomycin-treated patients.
score: 1.247194, Antimicrobial agents and chemotherapy, 2011, Minejima, Emi et. al.
Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE 1 and 9-β-halo derivatives with improved stability
score: 1.2471858, Bioorganic & Medicinal Chemistry, 2002, Maruyama, Toru et. al.
Synthesis and stability studies of phosphonoformate–amino acid conjugates: a new class of slowly releasing foscarnet prodrugs
score: 1.2470361, Bioorganic & Medicinal Chemistry Letters, 2004, Marma, Mong S; Kashemirov, Boris A; McKenna, Charles E
A neural network based prediction of octanol–water partition coefficients using atomic5 fragmental descriptors
score: 1.2469952, Bioorganic & Medicinal Chemistry Letters, 2004, Molnár, László et. al.
Identification of fusB-Mediated Fusidic Acid Resistance Islands in Staphylococcus epidermidis Isolates.
score: 1.2469386, Antimicrobial agents and chemotherapy, 2011, Chen, Hsiao-Jan et. al.
Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA
score: 1.2468528, Bioorganic & Medicinal Chemistry, 2006, Long, Yu-Hua et. al.
Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile
score: 1.2467173, Bioorganic & Medicinal Chemistry, 2012, Toba, Tetsuya et. al.
Activity of amoxicillin-clavulanate against penicillin-resistant Streptococcus pneumoniae in an experimental respiratory infection model in rats.
score: 1.2465849, Antimicrobial agents and chemotherapy, 1998, Smith, G M; Slocombe, B; Abbott, K H; Mizen, L W
Effects of metal ions on the rates and enantioselectivities of reactions catalyzed by a series of semisynthetic transaminases created by site directed mutagenesis
score: 1.2465376, Bioorganic & Medicinal Chemistry Letters, 1998, Qi, Dongfeng; Kuang, Hao; Distefano, Mark D.
Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea.
score: 1.2465232, Antimicrobial agents and chemotherapy, 2006, Karunajeewa, Harin A et. al.
Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists
score: 1.2464925, Bioorganic & Medicinal Chemistry, 2012, Becknell, Nadine C. et. al.
Metabolic studies on BMS-200475, a new antiviral compound active against hepatitis B virus.
score: 1.246335, Antimicrobial agents and chemotherapy, 1999, Yamanaka, G et. al.
Photochemical hammerhead ribozyme activation
score: 1.246318, Bioorganic & Medicinal Chemistry Letters, 2006, Young, Douglas D.; Deiters, Alexander
Structure–activity relationships of Erwinia carotovora quorum sensing signaling molecules
score: 1.2462982, Bioorganic & Medicinal Chemistry Letters, 2005, Welch, Martin et. al.
Use of PROTACS as molecular probes of angiogenesis
score: 1.2462817, Bioorganic & Medicinal Chemistry Letters, 2005, Bargagna-Mohan, Paola et. al.
A 4D-QSAR study on anti-HIV HEPT analogues
score: 1.2461597, Bioorganic & Medicinal Chemistry, 2006, Bak, Andrzej; Polanski, Jaroslaw
Efficacy of TAK-457, a novel intravenous triazole, against invasive pulmonary Aspergillosis in neutropenic mice.
score: 1.2460244, Antimicrobial agents and chemotherapy, 2002, Hayashi, Ryogo et. al.
Synthesis, cytotoxic activity on MCF-7 cell line and mutagenic activity of platinum(II) complexes with 2-substituted benzimidazole ligands
score: 1.2458168, European Journal of Medicinal Chemistry, 2003, Gümüş, Fatma et. al.
Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax.
score: 1.2457466, Antimicrobial agents and chemotherapy, 2012, Marfurt, Jutta et. al.
Efficient fluorescent sensors of oligopeptides by dithiobis(2-benzoylamide)-bridged bis(β-cyclodextrin)s: structure in solution, binding behavior, and thermodynamic origin
score: 1.2457393, Bioorganic & Medicinal Chemistry, 2005, Liu, Yu; Yang, Ying-Wei; Chen, Yong; Ding, Fei
S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.
score: 1.2457205, Antimicrobial agents and chemotherapy, 2012, Warrilow, Andrew G S et. al.
QSAR study on melanocortin-4 receptors by support vector machine
score: 1.2456356, European Journal of Medicinal Chemistry, 2010, Pourbasheer, Eslam et. al.
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
score: 1.2456086, Nature chemical biology, 2010, Thorne, Curtis A et. al.
alpha-Galactosylceramide and novel synthetic glycolipids directly induce the innate host defense pathway and have direct activity against hepatitis B and C viruses.
score: 1.2455326, Antimicrobial agents and chemotherapy, 2004, Mehta, Anand S et. al.
Rapid hydrolysis of amides under physiological conditions: Influence of the microenvironment on the stability of the amide bond
score: 1.2454147, Bioorganic & Medicinal Chemistry Letters, 1998, Glüsenkamp, K.-H. et. al.
Metallo-beta-lactamase producers in environmental microbiota: new molecular class B enzyme in Janthinobacterium lividum.
score: 1.2453504, Antimicrobial agents and chemotherapy, 2001, Rossolini, G M et. al.
Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (celastraceae)
score: 1.2453254, Bioorganic & Medicinal Chemistry, 2000, González, Antonio G. et. al.
A substituted 3,4-dihydropyrimidinone derivative (compound D22) prevents inflammation mediated neurotoxicity; role in microglial activation in BV-2 cells
score: 1.2452196, Bioorganic & Medicinal Chemistry Letters, 2012, Kwon, Oh Wook et. al.
Halting metastasis through CXCR4 inhibition
score: 1.2451892, Bioorganic & Medicinal Chemistry Letters, 2013, Ramsey, Deborah M.; McAlpine, Shelli R.
Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.
score: 1.2449913, Antimicrobial agents and chemotherapy, 2002, Beadle, James R et. al.
Synthesis of vanadyl-hypocrellin A complex and its photodynamic properties research
score: 1.2448719, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Chao et. al.
Synthesis of new esters and oximes with 4-aminobicyclo[2.2.2]octane structure and evaluation of their antitrypanosomal and antiplasmodial activities
score: 1.2448432, European Journal of Medicinal Chemistry, 2006, Seebacher, W. et. al.
Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist
score: 1.2448035, Bioorganic & Medicinal Chemistry Letters, 2012, Itoh, Yukihiro et. al.
Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist
score: 1.2448035, Bioorganic & Medicinal Chemistry Letters, 2012, Itoh, Yukihiro et. al.
Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist
score: 1.2448035, Bioorganic & Medicinal Chemistry Letters, 2012, Itoh, Yukihiro et. al.
Double Protein Knockdown of cIAP1 and CRABP-II Using a Hybrid Molecule Consisting of ATRA and IAPs Antagonist
score: 1.2448035, Bioorganic & Medicinal Chemistry Letters, 2012, Itoh, Yukihiro et. al.
QSAR Studies on some antimalarial sulfonamides
score: 1.2447136, Bioorganic & Medicinal Chemistry, 2001, Agrawal, Vijay K. et. al.
Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones.
score: 1.2446492, Antimicrobial agents and chemotherapy, 1998, Zhao, X et. al.
Pholasin luminescence is enhanced by addition of dehydrocoelenterazine
score: 1.2446383, Bioorganic & Medicinal Chemistry Letters, 2008, Kuse, Masaki; Tanaka, Eiko; Nishikawa, Toshio
Development of NS3/4A protease-based reporter assay suitable for efficiently assessing hepatitis C virus infection.
score: 1.2446002, Antimicrobial agents and chemotherapy, 2009, Pan, Kao-Lu et. al.
Inhibition of human immunodeficiency virus type 1 replication in latently infected cells by a novel IkappaB kinase inhibitor.
score: 1.2444624, Antimicrobial agents and chemotherapy, 2006, Victoriano, Ann Florence B et. al.
Two diarylurea electron transport inhibitors reduce Staphylococcus aureus hemolytic activity and protect cultured endothelial cells from lysis.
score: 1.2443725, Antimicrobial agents and chemotherapy, 2002, Proctor, R A et. al.
8-Quinolinamines and Their pro prodrug conjugates as potent blood-Schizontocidal antimalarial agents
score: 1.2443658, Bioorganic & Medicinal Chemistry, 2003, Vangapandu, Suryanarayana et. al.
Analogues of aspartic proteases synthesized by densely covering silica gel with carboxyl groups
score: 1.2443072, Bioorganic & Medicinal Chemistry Letters, 2002, Kim, Hyunsook et. al.
A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae
score: 1.2442686, Bioorganic & Medicinal Chemistry Letters, 2010, Zhang, Jian et. al.
Quantitative structure–Activity relationship study on sulfanilamide schiff's bases: carbonic anhydrase (CA) inhibitors
score: 1.244248, Bioorganic & Medicinal Chemistry, 2003, Agrawal, Vijay K. et. al.
In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.
score: 1.2442031, Antimicrobial agents and chemotherapy, 2011, Pascual, Aurélie et. al.
Antibacterial activity and specificity of the six human {alpha}-defensins.
score: 1.2441844, Antimicrobial agents and chemotherapy, 2005, Ericksen, Bryan; Wu, Zhibin; Lu, Wuyuan; Lehrer, Robert I
The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba
score: 1.2440758, Bioorganic & Medicinal Chemistry, 1996, Zhao, Geng-Xian et. al.
Synthesis and structure–activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents
score: 1.2440203, Bioorganic & Medicinal Chemistry, 2012, Yamazaki, Yuri et. al.
Synthesis and structure–activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents
score: 1.2440203, Bioorganic & Medicinal Chemistry, 2012, Yamazaki, Yuri et. al.
Peptide nucleic acid–metal complex conjugates: facile modulation of PNA–DNA duplex stability
score: 1.2439898, Bioorganic & Medicinal Chemistry Letters, 2003, Mokhir, Andriy; Stiebing, Roman; Kraemer, Roland
Reduction of a 4-pyrrole phenylacyl-containing peptide with trifluoroacetic acid–triisopropylsilane–phenol–H 2O during solid-phase peptide synthesis and its protein kinase C α inhibitory activity
score: 1.2439418, Bioorganic & Medicinal Chemistry Letters, 2005, Lee, Jung Hwan
Citrobacter spp. as a source of qnrB Alleles.
score: 1.2437525, Antimicrobial agents and chemotherapy, 2011, Jacoby, George A; Griffin, Caitlin M; Hooper, David C
Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action
score: 1.2436586, Bioorganic & Medicinal Chemistry, 1999, Rüngeler, Peter et. al.
Identification of 8-amino-2,5,7-trihydroxynaphthalene-1,4-dione, a novel intermediate in the biosynthesis of Streptomyces meroterpenoids
score: 1.2434864, Bioorganic & Medicinal Chemistry Letters, 2012, Isogai, Shota; Nishiyama, Makoto; Kuzuyama, Tomohisa
Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.
score: 1.2434494, Antimicrobial agents and chemotherapy, 2012, Okombo, John et. al.
Synthesis and absolute configuration of Stellettadine A
score: 1.243402, Bioorganic & Medicinal Chemistry Letters, 2001, Nozawa, Dai; Takikawa, Hirosato; Mori, Kenji
Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain
score: 1.243399, Bioorganic & Medicinal Chemistry Letters, 2007, Sexton, Kelly B. et. al.
A structure–activity relationship study of quinone compounds with trypanocidal activity
score: 1.2433813, European Journal of Medicinal Chemistry, 2005, Molfetta, F.A.; Bruni, A.T.; Honório, K.M.; da Silva, A.B.F.
Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus.
score: 1.2433424, Antimicrobial agents and chemotherapy, 2011, Shore, Anna C et. al.
Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
score: 1.2433002, Bioorganic & Medicinal Chemistry, 2006, Baramee, Apiwat et. al.
Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold
score: 1.2432816, Bioorganic & Medicinal Chemistry, 1999, Smith III, Amos B. et. al.
The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors
score: 1.2432767, Bioorganic & Medicinal Chemistry, 2002, Leung, Carmen et. al.
Synthesis and β-lactamase reactivity of α-substituted phenaceturates
score: 1.2430474, Bioorganic & Medicinal Chemistry, 2006, Adediran, S.A. et. al.
Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: synthesis and antitumour activity
score: 1.2426183, Bioorganic & Medicinal Chemistry, 2002, Baraldi, Pier Giovanni et. al.
2-Phenylimidazo[2,1- i]purin-5-ones
score: 1.2424611, Bioorganic & Medicinal Chemistry, 2003, Ozola, Vita et. al.
Efficient synthesis of oligonucleotide conjugates on solid-support using an (aminoethoxycarbonyl)aminohexyl group for 5′-terminal modification
score: 1.2424271, Bioorganic & Medicinal Chemistry Letters, 2009, Kojima, Naoshi et. al.
Activity of deferasirox in Mucorales: influences of species and exogenous iron.
score: 1.2424091, Antimicrobial agents and chemotherapy, 2011, Lewis, Russell E et. al.
Comparison of the efficacy and safety of oritavancin front-loaded dosing regimens to daily dosing: an analysis of the SIMPLIFI trial.
score: 1.2422761, Antimicrobial agents and chemotherapy, 2011, Dunbar, Lala M et. al.
Sirtuins as emerging anti-parasitic targets
score: 1.2421998, European Journal of Medicinal Chemistry, 2013, Zheng, Weiping
Sirtuins as emerging anti-parasitic targets
score: 1.2421998, European Journal of Medicinal Chemistry, 2013, Zheng, Weiping
Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa.
score: 1.2421441, Antimicrobial agents and chemotherapy, 2004, Girlich, Delphine; Naas, Thierry; Nordmann, Patrice
18-Vinyldeoxycorticosterone: a potent inhibitor of the bovine cytochrome P-450 11β
score: 1.2421163, Bioorganic & Medicinal Chemistry, 1998, Davioud, Elisabeth et. al.
New Carrier for Specific Delivery of Drugs to the Brain
score: 1.2421065, Bioorganic & Medicinal Chemistry, 2003, Sheha, Mahmoud et. al.
Methylation of imidazoline related compounds leads to loss of α2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands
score: 1.2419687, Bioorganic & Medicinal Chemistry, 2012, Schann, Stephan et. al.
A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses.
score: 1.2419456, Antimicrobial agents and chemotherapy, 1999, Howett, M K et. al.
Recognition of a non-standard base pair by thermostable DNA polymerases
score: 1.2418294, Bioorganic & Medicinal Chemistry Letters, 1998, Lutz, Michael J.; Horlacher, Jennifer; Benner, Steven A.
Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies
score: 1.2418146, Bioorganic & Medicinal Chemistry, 2002, Kim, Geun Tae et. al.
Corrigendum to “Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 6307]
score: 1.2417059, Bioorganic & Medicinal Chemistry Letters, 2010, Boezio, Alessandro A. et. al.
In vitro activity of fosfomycin against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: comparison of susceptibility testing procedures.
score: 1.2416805, Antimicrobial agents and chemotherapy, 2006, de Cueto, M et. al.
A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities
score: 1.2416278, Bioorganic & Medicinal Chemistry, 2000, Hasserodt, Jens; Janda, Kim D; Lerner, Richard A
In vitro activities of dalbavancin and nine comparator agents against anaerobic gram-positive species and corynebacteria.
score: 1.2414718, Antimicrobial agents and chemotherapy, 2003, Goldstein, Ellie J C et. al.
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity
score: 1.2414379, Bioorganic & Medicinal Chemistry Letters, 2012, Quang, Tran Hong et. al.
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity
score: 1.2414379, Bioorganic & Medicinal Chemistry Letters, 2012, Quang, Tran Hong et. al.
2-Arylidene-4-(4-phenoxy-phenyl)but-3-en-4-olides: Synthesis, reactions and biological activity
score: 1.2411797, European Journal of Medicinal Chemistry, 2005, Husain, Asif; Khan, M.S.Y.; Hasan, S.M.; Alam, M.M.
In vitro activity and killing effect of uperin 3.6 against gram-positive cocci isolated from immunocompromised patients.
score: 1.2411488, Antimicrobial agents and chemotherapy, 2005, Giacometti, Andrea et. al.
New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering
score: 1.2410838, Bioorganic & Medicinal Chemistry, 2004, Gopin, Anna; Rader, Christoph; Shabat, Doron
Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes
score: 1.2410572, European Journal of Medicinal Chemistry, 2012, Xu, Qinyuan et. al.
Interaction assay of oligosaccharide with lectins using glycosylasparagine
score: 1.2409805, Bioorganic & Medicinal Chemistry Letters, 2004, Mizuno, Mamoru et. al.
9 H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2 H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers
score: 1.2407106, Bioorganic & Medicinal Chemistry Letters, 2005, Vieira, Eric et. al.
Synthesis and cytotoxicity studies of new dimethylamino-functionalised and aryl-substituted titanocene anti-cancer agents
score: 1.2406767, European Journal of Medicinal Chemistry, 2008, Pampillón, Clara et. al.
Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.
score: 1.2406379, Antimicrobial agents and chemotherapy, 2011, Akbergenov, Rashid et. al.
Dirithromycin
score: 1.2406226, Bioorganic & Medicinal Chemistry, 1996,
Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa
score: 1.2405879, Bioorganic & Medicinal Chemistry, 2003, Lee, Seung Ho et. al.
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization
score: 1.2405229, Bioorganic & Medicinal Chemistry, 2012, Lecis, Daniele et. al.
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization
score: 1.2405229, Bioorganic & Medicinal Chemistry, 2012, Lecis, Daniele et. al.
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization
score: 1.2405229, Bioorganic & Medicinal Chemistry, 2012, Lecis, Daniele et. al.
Oral bioavailability and in vivo efficacy of the helicase-primase inhibitor BILS 45 BS against acyclovir-resistant herpes simplex virus type 1.
score: 1.2404681, Antimicrobial agents and chemotherapy, 2003, Duan, Jianmin et. al.
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase
score: 1.2404629, Bioorganic & Medicinal Chemistry, 2007, Burger, Pieter B. et. al.
Inclusion complexes of paclitaxel and oligo(ethylenediamino) bridged bis(β-cyclodextrin)s: solubilization and antitumor activity
score: 1.2403938, Bioorganic & Medicinal Chemistry, 2004, Liu, Yu et. al.
Development of a prostaglandin D 2 receptor antagonist: discovery of a new chemical lead
score: 1.2402694, European Journal of Medicinal Chemistry, 2005, Torisu, Kazuhiko et. al.
Dermcidin-derived peptides show a different mode of action than the cathelicidin LL-37 against Staphylococcus aureus.
score: 1.2402357, Antimicrobial agents and chemotherapy, 2009, Senyürek, Ilknur et. al.
Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.
score: 1.2401328, Antimicrobial agents and chemotherapy, 2011, Pérez-Llarena, Francisco José et. al.
Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
score: 1.240053, Bioorganic & Medicinal Chemistry Letters, 2012, Ellanki, Amarender Reddy et. al.
Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
score: 1.240053, Bioorganic & Medicinal Chemistry Letters, 2012, Ellanki, Amarender Reddy et. al.
Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria.
score: 1.2400195, Antimicrobial agents and chemotherapy, 2003, Pukrittayakamee, S et. al.
Pentamidine inhibition of group I intron splicing in Candida albicans correlates with growth inhibition.
score: 1.2398266, Antimicrobial agents and chemotherapy, 2000, Miletti, K E; Leibowitz, M J
A practical approach to the synthesis of hairpin polyamide–peptide conjugates through the use of a safety-catch linker
score: 1.2396113, Bioorganic & Medicinal Chemistry Letters, 2002, Fattori, Daniela et. al.
Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility.
score: 1.2394388, Antimicrobial agents and chemotherapy, 2005, Yen, Hui-Ling et. al.
N-Thiolated β-Lactam Antibacterials: Defining the Role of Unsaturation in the C 4 Side Chain
score: 1.2393317, Bioorganic & Medicinal Chemistry, 2003, Coates, Cristina et. al.
Interaction of heparin with cationic molecular probes: Probe charge is a major determinant of binding stoichiometry and affinity
score: 1.2392982, Bioorganic & Medicinal Chemistry Letters, 2010, Szelke, Helga et. al.
Preparation of 1,3,5-thiadiazine-2-thione derivatives of chitosan and their potential antioxidant activity in vitro
score: 1.2392703, Bioorganic & Medicinal Chemistry Letters, 2007, Ji, Xia et. al.
Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors
score: 1.2392672, Bioorganic & Medicinal Chemistry, 2012, Zhang, Yan-Bin et. al.
Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors
score: 1.2392672, Bioorganic & Medicinal Chemistry, 2012, Zhang, Yan-Bin et. al.
Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2
score: 1.2391894, Bioorganic & Medicinal Chemistry, 1998, Tellier, Frédérique et. al.
Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase.
score: 1.2391527, Antimicrobial agents and chemotherapy, 2006, Carter, K C et. al.
A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase
score: 1.2389333, Bioorganic & Medicinal Chemistry, 2003, Smyth, Timothy P; Wall, J.Gerard; Nitanai, Yasushi
Identification of a dendrimeric heparan sulfate-binding peptide that inhibits infectivity of genital types of human papillomaviruses.
score: 1.2387925, Antimicrobial agents and chemotherapy, 2010, Donalisio, Manuela et. al.
Preparation of fluorescent tocopherols for use in protein binding and localization with the α-tocopherol transfer protein
score: 1.2387388, Bioorganic & Medicinal Chemistry, 2006, Nava, Phillip et. al.
Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker
score: 1.238681, Bioorganic & Medicinal Chemistry Letters, 2009, Shimizu, Yuka; Bhakta, Mital S.; Segal, David J.
Inhibition of therapeutically important polymerases with high affinity bis-intercalators
score: 1.2385989, Bioorganic & Medicinal Chemistry Letters, 2012, Jain, Nitin; Francis, Subhashree; Friedman, Simon H.
Inclusion complexes of azadirachtin with native and methylated cyclodextrins: solubilization and binding ability
score: 1.2385142, Bioorganic & Medicinal Chemistry, 2005, Liu, Yu; Chen, Guo-Song; Chen, Yong; Lin, Jun
N-Oxide analogs of WAY-100635: new high affinity 5-HT 1A receptor antagonists
score: 1.2384088, Bioorganic & Medicinal Chemistry, 2005, Marchais-Oberwinkler, Sandrine et. al.
NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel.
score: 1.2383743, Antimicrobial agents and chemotherapy, 2012, Arpin, Corinne et. al.
Reduced glutathione-resisting 19F NMR sensors for detecting HNO
score: 1.2383226, Bioorganic & Medicinal Chemistry, 2012, Kitamura, Narufumi et. al.
Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells
score: 1.2382633, Bioorganic & Medicinal Chemistry, 2004, Zhang, Ting et. al.
Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle.
score: 1.2382108, Antimicrobial agents and chemotherapy, 2011, Slavic, Ksenija et. al.
Preparation of C 60-based active esters and coupling of C 60 moiety to amines or alcohols
score: 1.2381457, Bioorganic & Medicinal Chemistry Letters, 2008, Tsumoto, Hiroki et. al.
Mechanisms of resistance to imipenem and ampicillin in Enterococcus faecalis.
score: 1.2380977, Antimicrobial agents and chemotherapy, 2005, Ono, Seiji; Muratani, Tetsuro; Matsumoto, Tetsuro
Influence of carboxylic acid functionalities in ruthenium (II) polypyridyl complexes on DNA binding, cytotoxicity and antioxidant activity: Synthesis, structure and in vitro anticancer activity
score: 1.2380556, European Journal of Medicinal Chemistry, 2013, Sathiya Kamatchi, Thangavel et. al.
Tigecycline MIC testing by broth dilution requires use of fresh medium or addition of the biocatalytic oxygen-reducing reagent oxyrase to standardize the test method.
score: 1.2380273, Antimicrobial agents and chemotherapy, 2005, Bradford, Patricia A et. al.
Critical design features of phenyl carboxylate-containing polymer microbicides.
score: 1.2380253, Antimicrobial agents and chemotherapy, 2006, Rando, Robert F et. al.
Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar–protein interaction studies
score: 1.2379825, Bioorganic & Medicinal Chemistry Letters, 2007, Jiménez-Castells, Carmen et. al.
Structural studies on bioactive compounds. Part 29
score: 1.2378245, Bioorganic & Medicinal Chemistry, 2000, Hannah, Duncan R. et. al.
The design and synthesis of substituted biphenyl libraries
score: 1.2377508, Bioorganic & Medicinal Chemistry, 1996, Pavia, Michael R. et. al.
High-throughput screen for inhibitors of transglycosylase and/or transpeptidase activities of Escherichia coli penicillin binding protein 1b.
score: 1.2376597, Antimicrobial agents and chemotherapy, 2004, Chandrakala, B et. al.
Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.
score: 1.2376588, Antimicrobial agents and chemotherapy, 2011, Vilchèze, Catherine et. al.
Substitution of Gly with Ala enhanced the melanoma uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide
score: 1.2375187, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Jianquan; Miao, Yubin
MED-3DMC: A new tool to generate 3D conformation ensembles of small molecules with a Monte Carlo sampling of the conformational space
score: 1.2374936, European Journal of Medicinal Chemistry, 2009, Sperandio, Olivier et. al.
Synthesis of phosphonate derivatives of uridine, cytidine, and cytosine arabinoside
score: 1.2371171, Bioorganic & Medicinal Chemistry, 2000, Jung, Kang-Yeoun et. al.
Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl- l-amino acid dianion
score: 1.2370068, European Journal of Medicinal Chemistry, 2010, Zhang, Jinchao et. al.
A new ketolide, HMR 3004, active against streptococci inducibly resistant to erythromycin.
score: 1.236766, Antimicrobial agents and chemotherapy, 1998, Rosato, A et. al.
Synthesis and evaluation of new hydrazide derivatives as neuropeptide Y Y 5 receptor antagonists for the treatment of obesity
score: 1.2366535, Bioorganic & Medicinal Chemistry, 2004, Juanenea, Laura et. al.
Extended-spectrum beta-lactamases in Ireland, including a novel enzyme, TEM-102.
score: 1.2365711, Antimicrobial agents and chemotherapy, 2003, Morris, Dearbháile et. al.
Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)beta-L-2',3'-dideoxy-3'-thiacytidine.
score: 1.236405, Antimicrobial agents and chemotherapy, 1998, King, R W et. al.
The domino blocks: A simple solution for parallel solid-phase organic synthesis
score: 1.2363906, Bioorganic & Medicinal Chemistry Letters, 1998, Krchňák, Viktor; Paděra, Víteček
Coadministration of indinavir and nelfinavir in human immunodeficiency virus type 1-infected adults: safety, pharmacokinetics, and antiretroviral activity.
score: 1.2362176, Antimicrobial agents and chemotherapy, 2002, Riddler, Sharon A et. al.
Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
score: 1.2362175, European Journal of Medicinal Chemistry, 2012, Sashidhara, Koneni V. et. al.
Molecular modeling studies of the binding modes of aldose reductase inhibitors at the active site of human aldose reductase
score: 1.2360875, Bioorganic & Medicinal Chemistry, 1998, Lee, Yong S; Chen, Zhou; Kador, Peter F
Alachalasins A–G, new cytochalasins from the fungus Stachybotrys charatum
score: 1.2360232, Bioorganic & Medicinal Chemistry, 2008, Zhang, Yonggang et. al.
A new visual screening assay for catalytic antibodies with retro-aldol retro-Michael activity
score: 1.2360178, Bioorganic & Medicinal Chemistry Letters, 2007, Shamis, Marina; Barbas, Carlos F.; Shabat, Doron
Molecular mechanics parameterization of thionucleoside disulfides for modeling cross-linked duplex DNA
score: 1.2360098, Bioorganic & Medicinal Chemistry Letters, 1998, Coleman, Robert S.; McCary, Jason L.
Synthesis and biological activity of 8-azapurine and pyrazolo[4,3- d]pyrimidine analogues of myoseverin
score: 1.2359822, European Journal of Medicinal Chemistry, 2006, Kryštof, Vladimír et. al.
Recognition of a 10 base pair sequence of DNA and stereochemical control of the binding affinity of chiral hairpin polyamide–Hoechst 33258 conjugates
score: 1.2359115, Bioorganic & Medicinal Chemistry Letters, 2005, Reddy, Putta Mallikarjuna et. al.
Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms.
score: 1.2358858, Antimicrobial agents and chemotherapy, 2004, Evers, David L et. al.
Synthesis and evaluation of peptidic irreversible inhibitors of tissue transglutaminase
score: 1.2358, Bioorganic & Medicinal Chemistry, 2006, Pardin, Christophe et. al.
Functional synergy between antimicrobial peptoids and peptides against Gram-negative bacteria.
score: 1.2357352, Antimicrobial agents and chemotherapy, 2011, Chongsiriwatana, Nathaniel P et. al.
Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum
score: 1.235727, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Lulu et. al.
Generation of reactive oxygen species by a persulfide (BnSSH)
score: 1.2356613, Bioorganic & Medicinal Chemistry Letters, 2005, Chatterji, Tonika; Keerthi, Kripa; Gates, Kent S.
Hippuryl-α-methylphenylalanine and hippuryl-α-methylphenyllactic acid as substrates for carboxypeptidase A. Syntheses, kinetic evaluation and mechanistic implication
score: 1.235639, Bioorganic & Medicinal Chemistry, 2000, Lee, Mijoon; Kim, Dong H.
Bacterial resistance to antisense Peptide phosphorodiamidate morpholino oligomers.
score: 1.2353816, Antimicrobial agents and chemotherapy, 2012, Puckett, Susan E et. al.
Novel antiallergic agents. Part I: Synthesis and pharmacology of pyrimidine amide derivatives
score: 1.2353749, Bioorganic & Medicinal Chemistry, 1998, Ban, Masakazu et. al.
Novel O-[ 11C]methylated derivatives of candesartan as angiotensin II AT 1 receptor imaging ligands: Radiosynthesis and ex vivo evaluation in rats
score: 1.2353292, Bioorganic & Medicinal Chemistry, 2009, Hadizad, Tayebeh et. al.
Camptothecin-20-PEG ester transport forms: the effect of spacer groups on antitumor activity
score: 1.2353265, Bioorganic & Medicinal Chemistry, 1998, Greenwald, Richard B. et. al.
Cloning and nucleotide sequence of the DNA gyrase (gyrA) gene from Mycoplasma hominis and characterization of quinolone-resistant mutants selected in vitro with trovafloxacin.
score: 1.2353218, Antimicrobial agents and chemotherapy, 2000, Bébéar, C M et. al.
A novel method of estimation of lipophilicity using distance-based topological indices: dominating role of equalized electronegativity
score: 1.2353011, Bioorganic & Medicinal Chemistry, 2005, Agrawal, Vijay K. et. al.
Chemoenzymatic synthesis of both enantiomers of α-tocotrienol
score: 1.2351776, Bioorganic & Medicinal Chemistry, 2006, Chênevert, Robert; Courchesne, Gabriel; Pelchat, Nicholas
Benzamides derived from 1,2-diaminocyclopropane as novel ligands for human D 2 and D 3 dopamine receptors
score: 1.235105, Bioorganic & Medicinal Chemistry, 2000, Yang, Donglai et. al.
Enhanced binding of trigonal DNA–carbohydrate conjugates to lectin
score: 1.2350228, Bioorganic & Medicinal Chemistry Letters, 2012, Matsui, Masayuki; Ebara, Yasuhito
Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin–phenol adducts synthesized
score: 1.2349639, Bioorganic & Medicinal Chemistry, 2006, Prabhakar, K.R. et. al.
Interactions of beta-lactamases with sanfetrinem (GV 104326) compared to those with imipenem and with oral beta-lactams.
score: 1.2349442, Antimicrobial agents and chemotherapy, 1998, Babini, G S; Yuan, M; Livermore, D M
Thapsigargin analogues for targeting programmed death of androgen-Independent prostate cancer cells
score: 1.2349223, Bioorganic & Medicinal Chemistry, 1999, Brøgger Christensen, S et. al.
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors
score: 1.2348986, Bioorganic & Medicinal Chemistry, 2013, Kono, Mitsunori et. al.
Daptomycin antibiotic lock therapy in a rat model of staphylococcal central venous catheter biofilm infections.
score: 1.2348683, Antimicrobial agents and chemotherapy, 2011, Van Praagh, Andrew D G et. al.
Preparation of polymer-supported benzyllithium reagents
score: 1.2348319, Bioorganic & Medicinal Chemistry Letters, 2002, Itsuno, Shinichi; Tanaka, Satoshi; Hirao, Akira
Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors
score: 1.2346919, European Journal of Medicinal Chemistry, 2003, López-Rodrı́guez, Marı́a L. et. al.
Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureus.
score: 1.2345762, Antimicrobial agents and chemotherapy, 1999, Chambers, H F; Xiang, Q; Liu, ; Chow, L L; Hackbarth, C
Genetic analyses of mutations contributing to fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae.
score: 1.2345073, Antimicrobial agents and chemotherapy, 2001, Weigel, L M; Anderson, G J; Facklam, R R; Tenover, F C
Optimization of meropenem minimum concentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa.
score: 1.234493, Antimicrobial agents and chemotherapy, 2005, Tam, Vincent H et. al.
Polymerase incorporation of pyrene-nucleoside triphosphates
score: 1.2344492, Bioorganic & Medicinal Chemistry Letters, 2012, Hollenstein, Marcel et. al.
Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure.
score: 1.2342351, Antimicrobial agents and chemotherapy, 2007, Pallecchi, Lucia et. al.
Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides
score: 1.2340885, Bioorganic & Medicinal Chemistry Letters, 2008, Gerasimova, Yuliya V. et. al.
Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake
score: 1.2340342, Bioorganic & Medicinal Chemistry, 2007, Vicens, Marta et. al.
Experimental and ‘in silico’ analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups
score: 1.2340082, Bioorganic & Medicinal Chemistry, 2012, Domínguez, José L. et. al.
Highly sensitive detection of GG mismatched DNA by surfaces immobilized naphthyridine dimer through poly(ethylene oxide) linkers
score: 1.2339868, Bioorganic & Medicinal Chemistry Letters, 2004, Nakatani, Kazuhiko et. al.
Radical Scavenging by N-Aminoazaaromatics
score: 1.2339628, Bioorganic & Medicinal Chemistry, 2000, Itoh, Takashi et. al.
Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases
score: 1.233836, Bioorganic & Medicinal Chemistry, 2006, Monien, Bernhard H. et. al.
Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates.
score: 1.2338089, Antimicrobial agents and chemotherapy, 2001, Lee, A S; Teo, A S; Wong, S Y
Diagnostic PCR analysis of the occurrence of methicillin and tetracycline resistance genes among Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline for complicated skin and skin structure infections.
score: 1.2337707, Antimicrobial agents and chemotherapy, 2006, Jones, C Hal et. al.
GeneHunter, a transposon tool for identification and isolation of cryptic antibiotic resistance genes.
score: 1.233711, Antimicrobial agents and chemotherapy, 2003, Salipante, Stephen J; Barlow, Miriam; Hall, Barry G
Synthesis of 6”-Triazole-Substituted α-GalCer Analogues as Potent iNKT Cell Stimulating Ligands
score: 1.2337097, Bioorganic & Medicinal Chemistry, 2012, Pauwels, Nora et. al.
Design and synthesis of methyl 2-methyl-7,7-dihalo-5-phenyl-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity
score: 1.2336127, Bioorganic & Medicinal Chemistry, 2004, Mojarrad, Javid S; Miri, Ramin; Knaus, Edward E
CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loop.
score: 1.2335738, Antimicrobial agents and chemotherapy, 2001, Poirel, L et. al.
DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine
score: 1.2334307, Bioorganic & Medicinal Chemistry, 2006, Bai, Li-Ping et. al.
Oligonucleotides comprised of alternating 2′-Deoxy-2′-fluoro-β- d-arabinonucleosides and d-2′-deoxyribonucleosides (2′F-ANA/DNA ‘Altimers’) induce efficient RNA cleavage mediated by RNase H
score: 1.2333849, Bioorganic & Medicinal Chemistry Letters, 2002, Min, Kyung-Lyum et. al.
Studies on some glitazones having pyridine as the linker unit
score: 1.2333831, Bioorganic & Medicinal Chemistry, 2004, Ramachandran, Uma et. al.
Synthesis and anticonvulsant properties of triazolo- and imidazopyridazinyl carboxamides and carboxylic acids
score: 1.2332725, Bioorganic & Medicinal Chemistry, 1998, Moreau, Stéphane et. al.
A novel type of structurally simple nonpeptide inhibitors for α-chymotrypsin. Induced-fit binding of methyl 2-allyl-3-benzene-propanoate to the S 2 subsite pocket
score: 1.2332077, Bioorganic & Medicinal Chemistry, 1998, Kim, Dong H. et. al.
Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.
score: 1.2331673, Antimicrobial agents and chemotherapy, 2006, Lindegardh, Niklas et. al.
Synthesis of immunoreagents for detection of deoxypyrrololine, a cross-link of bone collagen
score: 1.2331605, Bioorganic & Medicinal Chemistry Letters, 2000, Adamczyk, Maciej; Johnson, Donald D.; Reddy, Rajarathnam E.
QSAR studies—potent benzodiazepine γ-secretase inhibitors
score: 1.2331481, Bioorganic & Medicinal Chemistry, 2005, Ravi Keerti, A.; Ashok Kumar, B.; Parthasarathy, T.; Uma, V.
Molecular Shape and Medicinal Chemistry: A Perspective
score: 1.2331011, Journal of Medicinal Chemistry, 2010, Nicholls, Anthony et. al.
Three-Dimensional common-Feature hypotheses for octopamine agonist 2-(arylimino)imidazolidines
score: 1.2330408, Bioorganic & Medicinal Chemistry, 2002, Hirashima, Akinori et. al.
Improved selectivity for the binding of naphthyridine dimer to guanine–guanine mismatch
score: 1.2330308, Bioorganic & Medicinal Chemistry, 2001, Nakatani, Kazuhiko; Sando, Shinusuke; Saito, Isao
QSAR for non-nucleoside inhibitors of HIV-1 reverse transcriptase
score: 1.232958, Bioorganic & Medicinal Chemistry, 2006, Duchowicz, Pablo R. et. al.
Xanthocillins as thrombopoietin mimetic small molecules
score: 1.2326936, Bioorganic & Medicinal Chemistry, 2005, Sakai, Ryuichi et. al.
SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.
score: 1.2326896, Antimicrobial agents and chemotherapy, 2011, Wachino, Jun-ichi et. al.
Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects
score: 1.2326337, European Journal of Medicinal Chemistry, 2012, Khurana, Jitender M. et. al.
Polar, functionalized guanine- O6 derivatives resistant to repair by O6 -alkylguanine–DNA alkyltransferase: implications for the design of DNA-modifying drugs
score: 1.2325632, European Journal of Medicinal Chemistry, 2006, Pletsas, Dimitrios et. al.
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.
score: 1.2324947, Antimicrobial agents and chemotherapy, 2012, Guiton, Pascale S et. al.
‘Mutational SURF’: A strategy for improving lead compounds identified from combinatorial libraries
score: 1.232467, Bioorganic & Medicinal Chemistry, 1996, Freier, Susan M. et. al.
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation
score: 1.2323927, Bioorganic & Medicinal Chemistry, 2012, Sedláček, Ondřej et. al.
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation
score: 1.2323927, Bioorganic & Medicinal Chemistry, 2012, Sedláček, Ondřej et. al.
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation
score: 1.2323927, Bioorganic & Medicinal Chemistry, 2012, Sedláček, Ondřej et. al.
Pharmacodynamic analysis of a serine protease inhibitor, MK-4519, against hepatitis C virus using a novel in vitro pharmacodynamic system.
score: 1.2323593, Antimicrobial agents and chemotherapy, 2012, Brown, Ashley N et. al.
The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin
score: 1.2323109, Bioorganic & Medicinal Chemistry, 2005, Zoidis, Grigoris et. al.
Synthesis and human leukocyte elastase inhibitory evaluation of phosphate triesters and acyl phosphates of penam sulfides and sulfones
score: 1.2322328, Bioorganic & Medicinal Chemistry, 2001, Laborde, Marı́a et. al.
A comparative molecular field analysis and molecular modelling studies on pyridylimidazole type of angiotensin II antagonists
score: 1.2321647, Bioorganic & Medicinal Chemistry, 1999, Yoo, Sung-eun et. al.
Hydantoin derivative formation from oxidation of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG) and incorporation of 14C-labeled 8-oxodG into the DNA of human breast cancer cells
score: 1.2321638, Bioorganic & Medicinal Chemistry Letters, 2005, Hah, Sang Soo et. al.
Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor
score: 1.2321203, Bioorganic & Medicinal Chemistry, 1997, Caldera, Patricia S. et. al.
Interaction of chromium(III) complex of chiral binaphthyl tetradentate ligand with DNA
score: 1.2320913, Bioorganic & Medicinal Chemistry, 2006, Vijayalakshmi, Rajamanickam et. al.
Synthesis and biological properties of a series of optically active 2-oxaisocephems
score: 1.2320296, Bioorganic & Medicinal Chemistry, 1995, Tsubouchi, Hidetsugu; Ishikawa, Hiroshi
Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.
score: 1.2319198, Bioorganic & Medicinal Chemistry Letters, 2012, Yamano, Yoshi; Arai, Masayoshi; Kobayashi, Motomasa
Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.
score: 1.2319198, Bioorganic & Medicinal Chemistry Letters, 2012, Yamano, Yoshi; Arai, Masayoshi; Kobayashi, Motomasa
Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.
score: 1.2319198, Bioorganic & Medicinal Chemistry Letters, 2012, Yamano, Yoshi; Arai, Masayoshi; Kobayashi, Motomasa
Diaminopropionic acid lipopeptides: Characterization studies of polyplexes aimed at pDNA delivery
score: 1.2319012, Bioorganic & Medicinal Chemistry Letters, 2012, Viola, Joana R. et. al.
Synthesis and characterization of a triazine dendrimer that sequesters iron(III) using 12 desferrioxamine B groups
score: 1.2318093, Bioorganic & Medicinal Chemistry, 2010, Lim, Jongdoo; Venditto, Vincent J.; Simanek, Eric E.
Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
score: 1.2317813, European Journal of Medicinal Chemistry, 2009, Vieira, Lígia Maria M. et. al.
Antifungal activity of the pradimicin derivative BMS 181184 in the treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits.
score: 1.2317527, Antimicrobial agents and chemotherapy, 1998, Gonzalez, C E et. al.
Quinolinyl- and Phenantridinyl-acetamides as Bradykinin B1 Receptor Antagonists
score: 1.231685, Bioorganic & Medicinal Chemistry Letters, 2012, Éles, János et. al.
Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil–isatin conjugates and their cytotoxic evaluation
score: 1.2316801, European Journal of Medicinal Chemistry, 2012, Kumar, Kewal et. al.
Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora
score: 1.231618, Bioorganic & Medicinal Chemistry, 2005, Keppler, Katrin; Humpf, Hans-Ulrich
In vitro and in vivo antibacterial activities of SM-216601, a new broad-spectrum parenteral carbapenem.
score: 1.231497, Antimicrobial agents and chemotherapy, 2005, Ueda, Yutaka et. al.
An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1 H-3-pyrrolecarboxamide, a key intermediate for atorvastatin synthesis
score: 1.2314875, Bioorganic & Medicinal Chemistry Letters, 2004, Pandey, Pramod.S; Srinivasa Rao, T
Molecular characterization of recombinant Pneumocystis carinii topoisomerase I: differential interactions with human topoisomerase I poisons and pentamidine.
score: 1.2312701, Antimicrobial agents and chemotherapy, 2002, van Dross, Rukiyah T; Sanders, Marilyn M
Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.
score: 1.2310609, Antimicrobial agents and chemotherapy, 2011, Mariner, Katherine et. al.
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: Synthesis, modelling and molecular pharmacology
score: 1.2310532, Bioorganic & Medicinal Chemistry, 2005, Frølund, Bente et. al.
Synergistic in vitro antiretroviral activity of a humanized monoclonal anti-CD4 antibody (TNX-355) and enfuvirtide (T-20).
score: 1.2309953, Antimicrobial agents and chemotherapy, 2006, Zhang, Xing-Quan et. al.
Mutations in folP associated with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from five continents.
score: 1.2308403, Antimicrobial agents and chemotherapy, 2005, Fiebelkorn, K R; Crawford, S A; Jorgensen, J H
An efficient and versatile synthesis of acylpolyamine spider toxins
score: 1.2308347, Bioorganic & Medicinal Chemistry Letters, 2002, Nihei, Ken-ichi et. al.
Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction
score: 1.2307865, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yasutsugu et. al.
Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction
score: 1.2307865, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yasutsugu et. al.
Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction
score: 1.2307865, Bioorganic & Medicinal Chemistry Letters, 2012, Tamura, Yasutsugu et. al.
Factors affecting the protease activity of venom from jellyfish Rhopilema esculentum Kishinouye
score: 1.2307358, Bioorganic & Medicinal Chemistry Letters, 2005, Li, Cuiping et. al.
Stereospecific synthesis of trans-arachidonic acids
score: 1.2307249, Bioorganic & Medicinal Chemistry Letters, 2001, Krishna, U.Murali et. al.
Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum beta-lactamases and class C beta-lactamases.
score: 1.230634, Antimicrobial agents and chemotherapy, 2011, Lagacé-Wiens, P R S et. al.
Fast and easy access to efficient bifunctional chelators for MRI applications
score: 1.2306179, Bioorganic & Medicinal Chemistry Letters, 2009, Gugliotta, Giuseppe et. al.
The formation of a covalent complex between a dipeptide ligand and the src SH2 domain
score: 1.230488, Bioorganic & Medicinal Chemistry Letters, 1998, Alligood, Krystal J. et. al.
In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility.
score: 1.230438, Antimicrobial agents and chemotherapy, 2006, Cota, Jason et. al.
Activity of trovafloxacin (with or without ampicillin-sulbactam) against enterococci in an in vitro dynamic model of infection.
score: 1.2304251, Antimicrobial agents and chemotherapy, 1998, Zinner, S H; Gilbert, D; Dudley, M N
Equilibrium shift by target DNA substrates for determination of DNA binding ligands
score: 1.2302343, Bioorganic & Medicinal Chemistry Letters, 2007, Tsujita, Saori et. al.
Synthesis and conformational analysis of His-Phe-Arg-Trp-NH 2 and analogues with antifungal properties
score: 1.2301841, Bioorganic & Medicinal Chemistry, 2006, Masman, Marcelo F. et. al.
Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins
score: 1.2301678, Bioorganic & Medicinal Chemistry, 2006, Huang, Liusheng; Kerns, Robert J.
3-(1-Piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D 4 receptor with improved selectivity over ion channels
score: 1.2301338, Bioorganic & Medicinal Chemistry, 1998, Collins, Ian et. al.
In vitro activities of the new semisynthetic glycopeptide telavancin (TD-6424), vancomycin, daptomycin, linezolid, and four comparator agents against anaerobic gram-positive species and Corynebacterium spp.
score: 1.2299968, Antimicrobial agents and chemotherapy, 2004, Goldstein, Ellie J C et. al.
6β-N-Heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists
score: 1.229986, Bioorganic & Medicinal Chemistry Letters, 2012, Yuan, Yunyun et. al.
6β-N-Heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists
score: 1.229986, Bioorganic & Medicinal Chemistry Letters, 2012, Yuan, Yunyun et. al.
6β-N-Heterocyclic Substituted Naltrexamine Derivative NAP as a Potential Lead to Develop Peripheral Mu Opioid Receptor Selective Antagonists
score: 1.229986, Bioorganic & Medicinal Chemistry Letters, 2012, Yuan, Yunyun et. al.
Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA
score: 1.2299853, Bioorganic & Medicinal Chemistry Letters, 2006, Sun, Hongxia et. al.
Origin of plasmid-mediated quinolone resistance determinant QnrA.
score: 1.2299687, Antimicrobial agents and chemotherapy, 2005, Poirel, Laurent et. al.
Mechanism underlying levofloxacin uptake by human polymorphonuclear neutrophils.
score: 1.2299584, Antimicrobial agents and chemotherapy, 1999, Vazifeh, D; Bryskier, A; Labro, M T
A novel naturally occurring tripyrrole with potential nuclease and anti-tumour properties
score: 1.2299545, Bioorganic & Medicinal Chemistry, 2006, Subramanian, Mahesh; Chander, Ramesh; Chattopadhyay, Subrata
Study of the intramolecular cyclization of N-methyl-3-phenyl- N-(2-( E)-phenylethenyl)- trans( cis)-oxiranecarboxamide – Syntheses of Homoclausenamide and Dehydroclausenamide
score: 1.2298897, European Journal of Medicinal Chemistry, 2008, Ma, Nianchun; Wu, Kemei; Huang, Liang
Abbott Physicochemical Tiering (APT) – A Unified Approach to HTS Triage
score: 1.2298728, Bioorganic & Medicinal Chemistry, 2012, Cox, Philip B; Gregg, Robert; Vasudevan, Anil
Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria.
score: 1.2298403, Antimicrobial agents and chemotherapy, 2012, Fischer, Carol L et. al.
Molecular probe for enzymatic activity with dual output
score: 1.2297218, Bioorganic & Medicinal Chemistry, 2007, Danieli, Eyal; Shabat, Doron
Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors
score: 1.2297007, Bioorganic & Medicinal Chemistry, 2005, Kitahata, Nobutaka et. al.
Novel allocolchicinoids with an eight membered B-ring
score: 1.2296661, Bioorganic & Medicinal Chemistry, 2000, Brecht, René et. al.
Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480.
score: 1.2295531, Antimicrobial agents and chemotherapy, 2011, Alffenaar, J W C et. al.
Synthesis of [11C]dehydropravastatin, a PET probe potentially useful for studying OATP1B1 and MRP2 transporters in the liver
score: 1.229428, Bioorganic & Medicinal Chemistry, 2012, Ijuin, Ryosuke et. al.
Synthesis of [11C]dehydropravastatin, a PET probe potentially useful for studying OATP1B1 and MRP2 transporters in the liver
score: 1.229428, Bioorganic & Medicinal Chemistry, 2012, Ijuin, Ryosuke et. al.
Synthesis of [11C]dehydropravastatin, a PET probe potentially useful for studying OATP1B1 and MRP2 transporters in the liver
score: 1.229428, Bioorganic & Medicinal Chemistry, 2012, Ijuin, Ryosuke et. al.
Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis.
score: 1.2293943, Antimicrobial agents and chemotherapy, 2012, Diaz, Lorena et. al.
Larvicidal isoxazoles: Synthesis and their effective susceptibility towardsAedes aegyptilarvae
score: 1.2293775, Bioorganic & Medicinal Chemistry, 2013, da Silva-Alves, Diana C.B. et. al.
Design, synthesis, and AMPA receptor antagonistic activity of a novel 6-nitro-3-oxoquinoxaline-2-carboxylic acid with a substituted phenyl group at the 7 position
score: 1.2292302, Bioorganic & Medicinal Chemistry, 2005, Takano, Yasuo et. al.
Antitrypanosomal activity of a new triazine derivative, SIPI 1029, In vitro and in model infections.
score: 1.2290648, Antimicrobial agents and chemotherapy, 1998, Bacchi, C J; Vargas, M; Rattendi, D; Goldberg, B; Zhou, W
Complexation of cyclic dodecadepsipeptide, Cereulide with ammonium salts
score: 1.2289142, Bioorganic & Medicinal Chemistry Letters, 2003, Pitchayawasin, Suthasinee et. al.
Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium
score: 1.2289073, Bioorganic & Medicinal Chemistry, 2002, Hiroya, Kou et. al.
Synthesis and Biological Evaluation of Some Hydrazone Derivatives as New Anticandidal and Anticancer Agents
score: 1.2288596, European Journal of Medicinal Chemistry, 2012, Altıntop, Mehlika Dilek et. al.
Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe.
score: 1.2287146, Antimicrobial agents and chemotherapy, 2005, Mammeri, Hedi et. al.
iPF 2α-III-17,18,19,20- d 4: Total synthesis and metabolism
score: 1.2286194, Bioorganic & Medicinal Chemistry Letters, 2005, Kim, Seongjin et. al.
Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.
score: 1.2285606, Antimicrobial agents and chemotherapy, 2006, Dahl, Erica L et. al.
Synthesis and biological evaluation of a novel decadentate ligand DEPA
score: 1.2285114, Bioorganic & Medicinal Chemistry Letters, 2008, Chong, Hyun-Soon et. al.
Homology modeling of MT 1 and MT 2 receptors
score: 1.2284322, European Journal of Medicinal Chemistry, 2008, Farce, Amaury et. al.
The synthesis and evaluation of 10- and 12-membered ring benzofused enediyne amino acids
score: 1.2283107, Bioorganic & Medicinal Chemistry, 2005, Du, Yanming et. al.
8- O-Azeloyl-14-benzoylaconine: A new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities
score: 1.2283058, Bioorganic & Medicinal Chemistry, 2005, Chodoeva, Ainura et. al.
In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine
score: 1.2283043, European Journal of Medicinal Chemistry, 1999, Donkor, Isaac O; Clark, Alice M
Synthesis of jaspaquinol and effect on viability of normal and malignant bladder epithelial cell lines
score: 1.2282894, Bioorganic & Medicinal Chemistry Letters, 2004, Demotie, Alexandre et. al.
Attenuation-based dual-fluorescent-protein reporter for screening translation inhibitors.
score: 1.2282659, Antimicrobial agents and chemotherapy, 2012, Osterman, Ilya A et. al.
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators
score: 1.2281971, Bioorganic & Medicinal Chemistry, 2005, Dei, Silvia et. al.
Characterizations of clinical isolates of clostridium difficile by toxin genotypes and by susceptibility to 12 antimicrobial agents, including fidaxomicin (OPT-80) and rifaximin: a multicenter study in Taiwan.
score: 1.2281323, Antimicrobial agents and chemotherapy, 2012, Liao, Chun-Hsing; Ko, Wen-Chien; Lu, Jang-Jih; Hsueh, Po-Ren
A novel target-specific, salt-resistant antimicrobial peptide against the cariogenic pathogen Streptococcus mutans.
score: 1.227967, Antimicrobial agents and chemotherapy, 2011, Mai, Junni et. al.
Synthesis and antinociceptive activity of some substituted-{5-[2-(1,2,3,4-tetrahydrocarbazol-9-yl)ethyl]tetrazol-1-yl}alkanones
score: 1.2279386, European Journal of Medicinal Chemistry, 2005, Rajasekaran, A.; Thampi, P.P.
Allosteric interactions and QSAR: On the role of ligand hydrophobicity
score: 1.2279135, Bioorganic & Medicinal Chemistry, 2003, Hansch, Corwin et. al.
Photodynamic effects of porphyrin and chlorin photosensitizers in human colon adenocarcinoma cells
score: 1.2277732, Bioorganic & Medicinal Chemistry, 2004, Banfi, Stefano et. al.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
score: 1.2277588, Antimicrobial agents and chemotherapy, 2001, Chang, F Y; Siu, L K; Fung, C P; Huang, M H; Ho, M
Synthesis of complex-type glycans derived from parasitic helminths
score: 1.2277545, Bioorganic & Medicinal Chemistry Letters, 2006, Nakano, Jun; Ohta, Hiromichi; Ito, Yukishige
Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72–85
score: 1.2277372, Bioorganic & Medicinal Chemistry Letters, 2000, Tselios, Theodore et. al.
Nitroxyl (HNO) release from new functionalized N-hydroxyurea-derived acyl nitroso-9,10-dimethylanthracene cycloadducts
score: 1.2277249, Bioorganic & Medicinal Chemistry Letters, 2004, Zeng, Bu-Bing et. al.
Production of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus
score: 1.2277161, Bioorganic & Medicinal Chemistry Letters, 2009, Chae, Choong-Sik et. al.
Effects of 8-methyl-2′-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides
score: 1.2276721, Bioorganic & Medicinal Chemistry, 2005, Virgilio, Antonella et. al.
Pyrazolo[3,4- b]quinoxalines. A new class of cyclin-Dependent kinases inhibitors
score: 1.2276669, Bioorganic & Medicinal Chemistry, 2002, Ortega, Miguel A. et. al.
Synthesis of aromatic C-xylosides by position inversion of glucose
score: 1.2276613, Bioorganic & Medicinal Chemistry, 2006, Malmberg, Jesper et. al.
Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents
score: 1.2276323, Bioorganic & Medicinal Chemistry, 2005, Hung, Chia-Cheng et. al.
Human methionine aminopeptidase type 2 in complex with l- and d-methionine
score: 1.2276086, Bioorganic & Medicinal Chemistry Letters, 2006, Nonato, M. Cristina; Widom, Joanne; Clardy, Jon
Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil.
score: 1.2275901, Antimicrobial agents and chemotherapy, 2012, Vanichtanankul, Jarunee et. al.
Synthetic studies on cyclic octapeptides: Yunnanin F and Hymenistatin
score: 1.2275712, European Journal of Medicinal Chemistry, 2005, Poojary, Boja; Belagali, Shiddappa L.
Synthesis of functionalised 2-aryl-5-nitro-1 H-indoles and their activity as bacterial NorA efflux pump inhibitors
score: 1.2275673, Bioorganic & Medicinal Chemistry, 2006, Samosorn, Siritron et. al.
Cleavage at 5-methylcytosine in DNA by photosensitized oxidation with 2-methyl-1,4-naphthoquinone tethered oligodeoxynucleotides
score: 1.2275425, Bioorganic & Medicinal Chemistry Letters, 2005, Yamada, Hisatsugu; Tanabe, Kazuhito; Nishimoto, Sei-ichi
PCR and restriction endonuclease assay for detection of a novel mutation associated with sulfonamide resistance in Neisseria meningitidis.
score: 1.2275333, Antimicrobial agents and chemotherapy, 2003, Bennett, Désirée E; Cafferkey, Mary T
Development and validation of a high-performance liquid chromatography method for determination of cefquinome concentrations in sheep plasma and its application to pharmacokinetic studies.
score: 1.2275207, Antimicrobial agents and chemotherapy, 2011, Uney, Kamil; Altan, Feray; Elmas, Muammer
In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: Synthesis, spectroscopic study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agents
score: 1.2274588, European Journal of Medicinal Chemistry, 2009, Kovala-Demertzi, Dimitra et. al.
Near-infrared fluorescent divalent RGD ligand for integrin αvβ3-targeted optical imaging
score: 1.2274198, Bioorganic & Medicinal Chemistry Letters, 2012, Ye, Yunpeng et. al.
Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum.
score: 1.2273557, Antimicrobial agents and chemotherapy, 2002, Bellais, Samuel; Naas, Thierry; Nordmann, Patrice
Efficient asymmetric synthesis of ( S)-2-ethylphenylpropanoic acid derivative, a selective agonist for human peroxisome proliferator-activated receptor alpha
score: 1.2273506, Bioorganic & Medicinal Chemistry Letters, 2002, Nomura, Masahiro; Tanase, Takahiro; Miyachi, Hiroyuki
Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period.
score: 1.2273322, Antimicrobial agents and chemotherapy, 2009, Kim, Hong Bin et. al.
Synthesis of 4,17-diazasteroid inhibitors of human 5α-reductase
score: 1.2273237, Bioorganic & Medicinal Chemistry, 1996, Morzycki, Jacek W. et. al.
Fabrication and application of neoglycolipid arrays in a microtiter plate
score: 1.2272707, Bioorganic & Medicinal Chemistry Letters, 2006, Huang, Gang-Liang; Zhang, Hou-Cheng; Wang, Peng-George
Linezolid is superior to vancomycin in experimental pneumonia caused by Superantigen-Producing staphylococcus aureus in HLA class II transgenic mice.
score: 1.2272469, Antimicrobial agents and chemotherapy, 2012, Karau, Melissa J et. al.
Paclitaxel esters of malic acid as prodrugs with improved water solubility
score: 1.2271781, Bioorganic & Medicinal Chemistry, 2000, Damen, Eric W.P et. al.
Catalytic asymmetric synthesis of cyclic α-alkyl-amino acid derivatives having a tetrasubstituted α-carbon
score: 1.2270848, Bioorganic & Medicinal Chemistry Letters, 2009, Wang, Yong-Gang; Mii, Haruka; Kano, Taichi; Maruoka, Keiji
Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.
score: 1.2270298, Antimicrobial agents and chemotherapy, 2006, Khan, Inshad Ali et. al.
Synthesis, crystal structure, antioxidant activities and DNA-binding studies of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-(4′-hydroxy) benzoyl hydrazone
score: 1.2270104, European Journal of Medicinal Chemistry, 2009, Wang, Qian; Yang, Zheng-Yin; Qi, Gao-Fei; Qin, Dong-Dong
Syntheses and odor of “bulky group”-modified sandalwood odorants: isophorono-β-santalol analogues
score: 1.2269948, European Journal of Medicinal Chemistry, 2006, Höfinghoff, J.; Buchbauer, G.; Holzer, W.; Wolschann, P.
Characterization and dynamics of middle ear fluid and nasopharyngeal isolates of Streptococcus pneumoniae from 12 children treated with levofloxacin.
score: 1.2269402, Antimicrobial agents and chemotherapy, 2008, Davies, Todd A et. al.
Combinations of cyclophilin inhibitor NIM811 with hepatitis C Virus NS3-4A Protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance.
score: 1.2268944, Antimicrobial agents and chemotherapy, 2008, Mathy, Joanna E; Ma, Sue; Compton, Teresa; Lin, Kai
Promotion of radiation-induced formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine by nitro 5-Deazaflavin derivatives
score: 1.2266558, Bioorganic & Medicinal Chemistry Letters, 2001, Kawamoto, Tetsuji et. al.
Dihydropyridines and atypical MDR: A novel perspective of designing general reversal agents for both typical and atypical MDR
score: 1.2265258, Bioorganic & Medicinal Chemistry, 2008, Miri, Ramin; Mehdipour, Ahmadreza
Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases
score: 1.2264869, Bioorganic & Medicinal Chemistry, 2013, Goldschmidt, Ruth et. al.
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.
score: 1.2264304, Antimicrobial agents and chemotherapy, 2000, Aguirrezabalaga, I et. al.
In vitro evolution of an HIV integrase binding protein from a library of C-terminal domain γS-crystallin variants
score: 1.2263865, Bioorganic & Medicinal Chemistry Letters, 2012, Moody, Issa S. et. al.
Effective artificial proteases synthesized by covering silica gel with aldehyde and various other organic groups
score: 1.2263649, Bioorganic & Medicinal Chemistry Letters, 2002, Kim, Hyunsook et. al.
Synthesis of 2-hydroxy acid from 2-amino acid by Clostridium butyricum
score: 1.2263383, Bioorganic & Medicinal Chemistry Letters, 1998, Khelifa, Nasser; Butel, Marie-José; Rimbault, Alain
Remarkable immunostimulation effects of hybrid liposomes on human peripheral blood mononuclear cells in vitro
score: 1.2262662, Bioorganic & Medicinal Chemistry Letters, 2007, Komizu, Yuji; Tomonaga, Yuka; Goto, Koichi; Ueoka, Ryuichi
Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar Rain Forest
score: 1.226081, Bioorganic & Medicinal Chemistry, 2012, Dai, Yumin et. al.
Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar Rain Forest
score: 1.226081, Bioorganic & Medicinal Chemistry, 2012, Dai, Yumin et. al.
Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia capuronii from the Madagascar Rain Forest
score: 1.226081, Bioorganic & Medicinal Chemistry, 2012, Dai, Yumin et. al.
Synthesis of PECAM-1-specific 64Cu PET imaging agent: Evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse
score: 1.2260783, Bioorganic & Medicinal Chemistry Letters, 2012, Xiao, Li et. al.
The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides
score: 1.2260082, Bioorganic & Medicinal Chemistry, 2006, Basilio, A. et. al.
Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants
score: 1.2259932, Bioorganic & Medicinal Chemistry Letters, 2006, Gupta, Yogita; Mathur, G.N.; Parvez, Masood; Verma, Sandeep
Synthesis and receptor binding affinity of carboxylate analogues of the mannose 6-phosphate recognition marker
score: 1.2259745, Bioorganic & Medicinal Chemistry, 2006, Jeanjean, Audrey et. al.
Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.
score: 1.2259264, Antimicrobial agents and chemotherapy, 2000, Liu, W; Shen, B
Toward high yield synthesis of peptide–oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation
score: 1.2257582, Bioorganic & Medicinal Chemistry Letters, 2005, Maurel, Frédéric et. al.
Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1.
score: 1.2256544, Antimicrobial agents and chemotherapy, 2011, Mahalingam, Alamelu et. al.
In vivo activity of aryl ozonides against Schistosoma species.
score: 1.2256277, Antimicrobial agents and chemotherapy, 2012, Keiser, Jennifer et. al.
Reduced Glutathione-Resisting 19F NMR Sensors for Detecting HNO
score: 1.2256235, Bioorganic & Medicinal Chemistry, 2012, Kitamura, Narufumi et. al.
4-Alkyliden-β-lactams conjugated to polyphenols: Synthesis and inhibitory activity
score: 1.2256192, Bioorganic & Medicinal Chemistry, 2005, Cainelli, Gianfranco et. al.
QSAR Study on tadpole narcosis
score: 1.22561, Bioorganic & Medicinal Chemistry, 2003, Agrawal, Vijay K. et. al.
α–β Chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix
score: 1.2256017, Bioorganic & Medicinal Chemistry Letters, 2004, Zafrul Azam, A.T.M. et. al.
A concise preparation of the fluorescent amino acid l-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis
score: 1.2255207, Bioorganic & Medicinal Chemistry, 2013, Koopmans, Timo et. al.
Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method.
score: 1.2254354, Antimicrobial agents and chemotherapy, 2009, Deyde, Varough M et. al.
High-Resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay
score: 1.2253817, Bioorganic & Medicinal Chemistry Letters, 2003, Ham, Young-Wan; Tse, Winston C.; Boger, Dale L.
Introduction of guanidinium-modified deoxyuridine into the substrate binding regions of DNAzyme 10–23 to enhance target affinity: Implications for DNAzyme design
score: 1.2253173, Bioorganic & Medicinal Chemistry Letters, 2010, Lam, Curtis H.; Perrin, David M.
N-Acetyl-6-sulfo- d-glucosamine as a promising mimic of N-Acetyl neuraminic acid
score: 1.2253148, Bioorganic & Medicinal Chemistry Letters, 2003, Sasaki, Kenji et. al.
synthesis and biological activity of 4-methyl-3,5-dioxane derivatives as thromboxane a 2 receptor antagonists
score: 1.2252602, Bioorganic & Medicinal Chemistry, 1999, Marusawa, Hiroshi et. al.
Facile synthesis of N-Fmoc-serine-S-GlcNAc: a potential molecular probe for the functional study of O-GlcNAc
score: 1.2251712, Bioorganic & Medicinal Chemistry Letters, 2000, Ohnishi, Yuki; Ichikawa, Mie; Ichikawa, Yoshitaka
Synthesis of N2-modified 7-methylguanosine 5′-monophosphates as nematode translation inhibitors
score: 1.2249485, Bioorganic & Medicinal Chemistry, 2012, Piecyk, Karolina et. al.
In vitro selection of hemin-binding catalytic RNA
score: 1.2249001, Bioorganic & Medicinal Chemistry Letters, 2009, Liu, Mingzhe; Kagahara, Takuma; Abe, Hiroshi; Ito, Yoshihiro
Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum.
score: 1.2248412, Antimicrobial agents and chemotherapy, 2004, Rodrigues Goulart, Herbert et. al.
Structure–affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT 3 receptor
score: 1.2247351, Bioorganic & Medicinal Chemistry, 2005, Cappelli, Andrea et. al.
Highly regioselective enzymatic synthesis of polymerizable derivatives of methyl shikimate
score: 1.2247177, Bioorganic & Medicinal Chemistry Letters, 2007, Li, Chao et. al.
Characterization of H2O-forming NADH oxidase from Streptococcus pyogenes and its application in l-rare sugar production
score: 1.224665, Bioorganic & Medicinal Chemistry Letters, 2012, Gao, Hui et. al.
Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles
score: 1.2245914, Bioorganic & Medicinal Chemistry Letters, 2012, Lal, Kashmiri; Kumar, Ashwani; Pavan, M.S.; Kaushik, C.P.
Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.
score: 1.2245832, Antimicrobial agents and chemotherapy, 2004, Richter, Sara et. al.
Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260).
score: 1.2245434, Antimicrobial agents and chemotherapy, 2000, Demeter, L M et. al.
Characterization of the Novel CMT Enzyme TEM-154.
score: 1.2244654, Antimicrobial agents and chemotherapy, 2011, Robin, Frédéric et. al.
Synthesis and antiproliferative potency of 9-β- d-arabinofuranosyl-2-fluoroadenine phospholipid adducts
score: 1.2244521, Bioorganic & Medicinal Chemistry, 1999, Brachwitz, H. et. al.
MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation.
score: 1.2243523, Antimicrobial agents and chemotherapy, 2003, Rossi, Jutta et. al.
Synthesis of N 2-(substituted benzyl)-3-(4-methylphenyl)indazoles as novel anti-angiogenic agents
score: 1.2242658, Bioorganic & Medicinal Chemistry, 2006, Huang, Li-Jiau et. al.
Synthesis and evaluation of curcumin-related compounds for anticancer activity
score: 1.224259, European Journal of Medicinal Chemistry, 2012, Wei, Xingchuan et. al.
Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.
score: 1.2242021, Antimicrobial agents and chemotherapy, 2004, Novotny, Guy W et. al.
The Synthesis and Biological Evaluation of Novel Bridging Nucleoside Analogues
score: 1.2241926, Bioorganic & Medicinal Chemistry, 2002, Marzabadi, Cecilia H. et. al.
Preparation of oligonucleotides without aldehyde abasic sites
score: 1.2241871, Bioorganic & Medicinal Chemistry Letters, 2001, Krotz, Achim H. et. al.
Synthesis of two new heteroaromatic β-carboline-fused pentacycles. observation of a new intercalating agent
score: 1.2241861, Bioorganic & Medicinal Chemistry Letters, 2000, Csányi, Dorottya et. al.
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2
score: 1.2241477, Bioorganic & Medicinal Chemistry, 2012, Tanabe, Genzoh et. al.
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2
score: 1.2241477, Bioorganic & Medicinal Chemistry, 2012, Tanabe, Genzoh et. al.
A Practical Synthesis of 3,4-Diethoxybenzthioamide Based on Friedel–Crafts Reaction with Potassium Thiocyanate in Methanesulfonic Acid
score: 1.22401, Bioorganic & Medicinal Chemistry Letters, 2002, Aki, Shinji et. al.
Bone-targeting glycol and NSAIDS ester prodrugs of rhein: Synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies
score: 1.2239685, European Journal of Medicinal Chemistry, 2012, Cai, Jin et. al.
Differing effects of combination chemotherapy with meropenem and tobramycin on cell kill and suppression of resistance of wild-type Pseudomonas aeruginosa PAO1 and its isogenic MexAB efflux pump-overexpressed mutant.
score: 1.2239252, Antimicrobial agents and chemotherapy, 2009, Drusano, G L et. al.
Synthesis of 8-aminoadenosine 5′-(aminoalkyl phosphates), analogues of aminoacyl adenylates
score: 1.2238034, Bioorganic & Medicinal Chemistry, 2006, Yousefi-Salakdeh, Esmail et. al.
N-Thiolated β-lactams: A new family of anti- Bacillus agents
score: 1.2237441, Bioorganic & Medicinal Chemistry Letters, 2006, Turos, Edward et. al.
Kinetic analysis of Enterococcus faecium L,D-transpeptidase inactivation by carbapenems.
score: 1.2237217, Antimicrobial agents and chemotherapy, 2012, Dubée, Vincent et. al.
Design and synthesis of novel imidazole derivatives as potent inhibitors of allene oxide synthase(CYP74)
score: 1.2235476, Bioorganic & Medicinal Chemistry, 2002, Oh, Keimei; Murofushi, Noboru
Design, Synthesis and Antimicrobial Activities of Nitroimidazole Derivatives Containing 1,3,4-Oxadiazole Scaffold as FabH Inhibitors
score: 1.2235422, Bioorganic & Medicinal Chemistry, 2012, Li, Yao et. al.
Synthesis and evaluation of NO-release from symmetrically substituted furoxans
score: 1.2235274, Bioorganic & Medicinal Chemistry Letters, 2006, Nirode, William F. et. al.
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases
score: 1.223522, Bioorganic & Medicinal Chemistry, 2012, Mak, Lok Hang et. al.
2-Carboxymethylendothal analogues as affinity probes for stabilized protein phosphatase 2A
score: 1.2235208, Bioorganic & Medicinal Chemistry, 1999, Laidley, Charles W et. al.
In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis.
score: 1.2234673, Antimicrobial agents and chemotherapy, 2007, Karlowsky, James A et. al.
In vitro susceptibilities of Capnocytophaga isolates to beta-lactam antibiotics and beta-lactamase inhibitors.
score: 1.2233903, Antimicrobial agents and chemotherapy, 2000, Jolivet-Gougeon, A et. al.
Site of chemical modifications in CpG containing phosphorothiate oligodeoxynucleotide modulates its immunostimulatory activity
score: 1.2232405, Bioorganic & Medicinal Chemistry Letters, 1999, Qiuyan Zhao, ; Dong Yu, ; Agrawal, Sudhir
Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses.
score: 1.2232378, Antimicrobial agents and chemotherapy, 2002, Smee, Donald F et. al.
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
score: 1.2231346, Antimicrobial agents and chemotherapy, 2005, Crespan, Emmanuele et. al.
Susceptibility of herpes simplex virus isolated from genital herpes lesions to ASP2151, a novel helicase-primase inhibitor.
score: 1.223093, Antimicrobial agents and chemotherapy, 2012, Katsumata, Kiyomitsu et. al.
Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model.
score: 1.2230905, Antimicrobial agents and chemotherapy, 2008, Hurwitz, Selwyn J et. al.
Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus.
score: 1.222959, Antimicrobial agents and chemotherapy, 2002, Antonio, Martin; McFerran, Neil; Pallen, Mark J
Efficient cleavage of RNA, enhanced cellular uptake, and controlled intracellular localization of conjugate DNAzymes
score: 1.2228998, Bioorganic & Medicinal Chemistry Letters, 2005, Kubo, Takanori et. al.
Synthesis and Biological Evaluation of 99mTc(CO)3(His-CB) as a Tumor Imaging Agent
score: 1.2228211, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Jianjun et. al.
Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents
score: 1.2227866, European Journal of Medicinal Chemistry, 2003, Holla, B.Shivarama et. al.
N-Demethylation of N-methyl alkaloids with ferrocene
score: 1.2227275, Bioorganic & Medicinal Chemistry Letters, 2010, Kok, Gaik B.; Scammells, Peter J.
Synthesis and biochemical evaluation of a cyclic RGD oxorhenium complex as new ligand of α Vβ 3 integrin
score: 1.2227193, European Journal of Medicinal Chemistry, 2009, Aufort, Marie et. al.
Lethality of quinolones against Mycobacterium smegmatis in the presence or absence of chloramphenicol.
score: 1.2227072, Antimicrobial agents and chemotherapy, 2005, Malik, Muhammad et. al.
Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents
score: 1.2226857, European Journal of Medicinal Chemistry, 2005, Won, Shen-Jeu et. al.
Syntheses and evaluation of pyridazine and pyrimidine Containing bioisosteres of (±)-Pyrido[3.4-b]homotropane and Pyrido-[3.4-b]tropane as novel nAChR ligands
score: 1.2225591, Bioorganic & Medicinal Chemistry, 2002, Gündisch, Daniela et. al.
Dimethyldioxirane epoxidation of polycyclic fluoranthene hydrocarbons
score: 1.2221921, Bioorganic & Medicinal Chemistry Letters, 1999, Liu, Fushuang; Cho, Bongsup P.
Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50.
score: 1.22217, Antimicrobial agents and chemotherapy, 2000, Cui, L et. al.
Conformational control of cyclosporin through substitution of the N-5 position. A new class of cyclosporin antagonists
score: 1.2221595, Bioorganic & Medicinal Chemistry, 1997, Papageorgiou, Christos et. al.
Synthesis and Biological Studies of Novel Neurotensin(8–13) Mimetics
score: 1.2220926, Bioorganic & Medicinal Chemistry, 2002, Hong, Feng et. al.
Human immunodeficiency virus type 1 (HIV-1) integration: a potential target for microbicides to prevent cell-free or cell-associated HIV-1 infection.
score: 1.2220679, Antimicrobial agents and chemotherapy, 2008, Terrazas-Aranda, Katty et. al.
Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids
score: 1.2220503, Bioorganic & Medicinal Chemistry, 2004, Murakami, Chihiro et. al.
Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer’s disease
score: 1.2220466, Bioorganic & Medicinal Chemistry Letters, 2013, Jiménez-Aligaga, Karim et. al.
Substituted pyrido[3,2- b]oxazin-3(4 H)-ones: synthesis and evaluation of antinociceptive activity
score: 1.2220015, Bioorganic & Medicinal Chemistry, 1998, Savelon, L. et. al.
Susceptibility of Pneumocystis to echinocandins in suspension and biofilm cultures.
score: 1.2219665, Antimicrobial agents and chemotherapy, 2011, Cushion, Melanie T; Collins, Margaret S
In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase.
score: 1.2219638, Antimicrobial agents and chemotherapy, 2001, Reynolds, M G; Oh, J; Roos, D S
Biochemical-genetic analysis and distribution of FAR-1, a class A beta-lactamase from Nocardia farcinica.
score: 1.2219446, Antimicrobial agents and chemotherapy, 1999, Laurent, F et. al.
Caged compounds of a 2-deoxyglucose: Facile synthesis and their photoreactivity
score: 1.2219122, Bioorganic & Medicinal Chemistry Letters, 1998, Watanabe, Soichiro; Hirokawa, Riko; Iwamura, Michiko
A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors
score: 1.2218962, Bioorganic & Medicinal Chemistry Letters, 2012, Schünemann, Katrin et. al.
Dimer of 2,7-diamino-1,8-naphthyridine for the detection of mismatches formed by pyrimidine nucleotide bases
score: 1.2218812, Bioorganic & Medicinal Chemistry, 2008, Kobori, Akio; Nakatani, Kazuhiko
Quantitative analysis of a parasitic antiviral strategy.
score: 1.2218702, Antimicrobial agents and chemotherapy, 2004, Kim, Hwijin; Yin, John
Spider venom peptides for gene therapy of Chlamydia infection.
score: 1.2218666, Antimicrobial agents and chemotherapy, 2011, Lazarev, Vassili N et. al.
Comparison of human immunodeficiency virus type 1 Pr55(Gag) and Pr160(Gag-pol) processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors.
score: 1.2218236, Antimicrobial agents and chemotherapy, 2000, Speck, R R; Flexner, C; Tian, C J; Yu, X F
Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients.
score: 1.2217743, Antimicrobial agents and chemotherapy, 2011, Garonzik, S M et. al.
A mimic of the pyruvate dehydrogenase complex
score: 1.2217511, Bioorganic & Medicinal Chemistry Letters, 2010, Zhao, Huanyu; Breslow, Ronald
Application of PC-ANN and PC-LS-SVM in QSAR of CCR1 antagonist compounds: A comparative study
score: 1.2217016, European Journal of Medicinal Chemistry, 2010, Shahlaei, Mohsen; Fassihi, Afshin; Saghaie, Lotfollah
Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation
score: 1.2216712, Bioorganic & Medicinal Chemistry, 2004, Raić-Malić, Silvana et. al.
“Self-activating” chemical nuclease: Ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant
score: 1.2216651, European Journal of Medicinal Chemistry, 2009, Li, Kun et. al.
Lovastatin has significant activity against zygomycetes and interacts synergistically with voriconazole.
score: 1.2216327, Antimicrobial agents and chemotherapy, 2006, Chamilos, Georgios et. al.
Synthesis and antitumor activity of cis-dichloridoplatinum(II) complexes of 1,1′-biisoquinolines
score: 1.2215794, European Journal of Medicinal Chemistry, 2010, Kuo, Chen-Yuan; Wu, Ming-Jung; Lin, Chu-Chieh
β-Lapachone analogs with enhanced antiproliferative activity
score: 1.2215412, European Journal of Medicinal Chemistry, 2012, Ríos-Luci, Carla et. al.
N-(Hydroxyaminocarbonyl)phenylalanine
score: 1.2214519, Bioorganic & Medicinal Chemistry, 2001, Chung, Sang J.; Kim, Dong H.
Synthesis of novel N-diazeniumdiolates based on hyperbranched polyethers
score: 1.2214257, Bioorganic & Medicinal Chemistry Letters, 2008, Kou, Yuxia; Wan, Ajun
A histone deacetylase-dependent screen in yeast
score: 1.2213225, Bioorganic & Medicinal Chemistry, 2010, Weerasinghe, Sujith V.W. et. al.
A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters
score: 1.2212937, Bioorganic & Medicinal Chemistry Letters, 2003, Cheruvallath, Zacharia S et. al.
Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors
score: 1.22107, Bioorganic & Medicinal Chemistry, 2012, Kumar, Satish; Namkung, Wan; Verkman, A.S.; Sharma, Pawan K.
Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors
score: 1.22107, Bioorganic & Medicinal Chemistry, 2012, Kumar, Satish et. al.
Plasmid-mediated resistance to expanded-spectrum cephalosporins among Enterobacter aerogenes strains.
score: 1.2210625, Antimicrobial agents and chemotherapy, 1998, Pitout, J D et. al.
Universal polyethylene glycol linkers for attaching receptor ligands to quantum dots
score: 1.2210558, Bioorganic & Medicinal Chemistry Letters, 2006, Tomlinson, Ian D. et. al.
A new convenient transformation of erythromycin a into clarithromycin
score: 1.2209933, Bioorganic & Medicinal Chemistry, 1999, Allevi, Pietro; Longo, Alessandra; Anastasia, Mario
Activity of glycopeptides against Staphylococcus aureus infection in a rabbit endocarditis model: MICs do not predict in vivo efficacy.
score: 1.2209613, Antimicrobial agents and chemotherapy, 2005, Asseray, Nathalie et. al.
The substrate specificity of cytochrome P450 cam
score: 1.2209189, Bioorganic & Medicinal Chemistry, 1998, Zhang, Zhoupeng et. al.
Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins
score: 1.2208384, Bioorganic & Medicinal Chemistry, 2008, Jullian, Carolina et. al.
Role of positional hydrophobicity in the leishmanicidal activity of magainin 2.
score: 1.2206174, Antimicrobial agents and chemotherapy, 2004, Guerrero, Esther et. al.
Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid
score: 1.2205855, Bioorganic & Medicinal Chemistry, 2012, Lee, Yun Suk et. al.
Antistaphylococcal activity of CB-181963 (CAB-175), an experimental parenteral cephalosporin.
score: 1.2205497, Antimicrobial agents and chemotherapy, 2004, Hoellman, Dianne B; Pankuch, Glenn A; Appelbaum, Peter C
On-bead cyclization in a combinatorial library of 15,625 octapeptides
score: 1.2203998, Bioorganic & Medicinal Chemistry, 2009, Fluxa, Viviana S.; Reymond, Jean-Louis
Synthesis and structure–activity relationships of new antimicrobial active multisubstituted benzazole derivatives
score: 1.2202956, European Journal of Medicinal Chemistry, 2004, Yildiz-Oren, Ilkay et. al.
CTX-M-93, a CTX-M variant lacking penicillin hydrolytic activity.
score: 1.220163, Antimicrobial agents and chemotherapy, 2011, Djamdjian, Laura et. al.
Rational design and synthesis of peptide ligands for an anti-Carbohydrate antibody and Their immunochemical characterization
score: 1.2201624, Bioorganic & Medicinal Chemistry, 2003, Johnson, Margaret A; Eniade, Adewale A; Pinto, B.Mario
Synergistic activity of trovafloxacin and ceftriaxone or vancomycin against Streptococcus pneumoniae with various penicillin susceptibilities.
score: 1.2201374, Antimicrobial agents and chemotherapy, 1998, Nicolau, D P; Tessier, P R; Quintiliani, R; Nightingale, C H
N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases
score: 1.2200914, Bioorganic & Medicinal Chemistry Letters, 2012, Santana, Ana Bela et. al.
N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases
score: 1.2200914, Bioorganic & Medicinal Chemistry Letters, 2012, Santana, Ana Bela et. al.
N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases
score: 1.2200914, Bioorganic & Medicinal Chemistry Letters, 2012, Santana, Ana Bela et. al.
In vitro activities of RWJ-54428 (MC-02,479) against multiresistant gram-positive bacteria.
score: 1.220081, Antimicrobial agents and chemotherapy, 2001, Chamberland, S et. al.
4,4′-Dimethoxytrityl group derived from secondary alcohols: Are they removed slowly under acidic conditions?
score: 1.2200239, Bioorganic & Medicinal Chemistry Letters, 2005, Krishna Kumar, R.; Ravikumar, Vasulinga T.
An alternative to Western blot analysis using RNA aptamer-functionalized quantum dots
score: 1.2199906, Bioorganic & Medicinal Chemistry Letters, 2010, Shin, Seonmi et. al.
Conversion of oxacillin-resistant staphylococci from heterotypic to homotypic resistance expression.
score: 1.2199661, Antimicrobial agents and chemotherapy, 2002, Finan, J E et. al.
Inhibition of therapeutically important polymerases with high affinity bis-intercalators
score: 1.2199392, Bioorganic & Medicinal Chemistry Letters, 2012, Jain, Nitin; Francis, Subhashree; Friedman, Simon H.
Inhibition of therapeutically important polymerases with high affinity bis-intercalators
score: 1.2199392, Bioorganic & Medicinal Chemistry Letters, 2012, Jain, Nitin; Francis, Subhashree; Friedman, Simon H.
Inhibition of therapeutically important polymerases with high affinity bis-intercalators
score: 1.2199392, Bioorganic & Medicinal Chemistry Letters, 2012, Jain, Nitin; Francis, Subhashree; Friedman, Simon H.
FAD-Mediated enzymatic conversion of NAD + to NADH: Application to chiral synthesis of L-lactate
score: 1.2198966, Bioorganic & Medicinal Chemistry Letters, 1998, Leonida, Mihaela Draganoiu et. al.
Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis.
score: 1.2197064, Antimicrobial agents and chemotherapy, 2007, Julian, Kathleen et. al.
A novel synthesis of d-galactofuranosyl, d-glucofuranosyl and d-mannofuranosyl 1-phosphates based on remote activation of new and free hexofuranosyl donors
score: 1.2196838, Bioorganic & Medicinal Chemistry Letters, 2002, Ferrières, Vincent et. al.
Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin
score: 1.2196329, European Journal of Medicinal Chemistry, 2006, Raimondi, Maria Valeria et. al.
Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.
score: 1.2196085, Antimicrobial agents and chemotherapy, 2006, Michot, Jean-Michel et. al.
A practical synthesis of the serotonin 5-HT 2a receptor antagonist mdl 100907, its enantiomer and their 3-phenolic derivatives as precursors for [ 11c]labeled pet ligands
score: 1.2195434, Bioorganic & Medicinal Chemistry, 2000, Ullrich, Thomas; Rice, Kenner C
Inhibition of envelope-mediated CD4+-T-cell depletion by human immunodeficiency virus attachment inhibitors.
score: 1.2193158, Antimicrobial agents and chemotherapy, 2009, Alexander, Louis et. al.
Survey of resistance of herpes simplex virus to acyclovir in northwest England.
score: 1.219229, Antimicrobial agents and chemotherapy, 1998, Christophers, J et. al.
α-Mannosidase activity from antibody raised against a glucal antigen
score: 1.2192027, Bioorganic & Medicinal Chemistry Letters, 1998, Yu, Jaehoon
Structure-binding relation of philanthotoxins from nicotinic acetylcholine receptor binding assay
score: 1.2192015, Bioorganic & Medicinal Chemistry, 1997, Nakanishi, Koji et. al.
Teicoplanin stress-selected mutations increasing sigma(B) activity in Staphylococcus aureus.
score: 1.2191776, Antimicrobial agents and chemotherapy, 2001, Bischoff, M; Berger-Bächi, B
Development of an affinity-driven cross-linker: isolation of a vitamin D receptor associated factor
score: 1.2191523, Bioorganic & Medicinal Chemistry Letters, 2000, Swamy, Narasimha; Addo, James K; Ray, Rahul
A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine and its picrate Mn(II) complex: Synthesis, crystal structure and DNA-binding properties
score: 1.2191239, European Journal of Medicinal Chemistry, 2010, Wu, Huilu et. al.
Fluoxetine is a potent inhibitor of coxsackievirus replication.
score: 1.2190433, Antimicrobial agents and chemotherapy, 2012, Zuo, Jun et. al.
Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents
score: 1.2190123, Bioorganic & Medicinal Chemistry, 1999, Krotz, Achim H; Cole, Douglas L; Ravikumar, Vasulinga T
15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives
score: 1.2190021, Bioorganic & Medicinal Chemistry, 2004, Klimko, Peter et. al.
Research on l-Nucleosides. synthesis and biological evaluation of a series of l- and d-2′,3′-Dideoxy-3′-[tris(methylthio)methyl]-β-pentofuranosyl nucleosides
score: 1.2188301, Bioorganic & Medicinal Chemistry, 2003, Mugnaini, Claudia et. al.
Properties of mixed backbone oligonucleotides containing 3′-O-methyl ribonucleosides
score: 1.2186472, Bioorganic & Medicinal Chemistry Letters, 1999, Kumar, Prabhat; Takaku, Hiroshi
Properties of mixed backbone oligonucleotides containing 3′-O-methyl ribonucleosides
score: 1.2186472, Bioorganic & Medicinal Chemistry Letters, 1999, Kumar, Prabhat; Takaku, Hiroshi
Formation of diazoate intermediate upon nitrous acid and nitric oxide treatment of 2′-deoxyadenosine
score: 1.2185929, Bioorganic & Medicinal Chemistry Letters, 2009, Suzuki, Toshinori et. al.
Chemotherapy of leishmaniasis. Part IX: Synthesis and bioevaluation of aryl substituted ketene dithioacetals as antileishmanial agents
score: 1.2185316, Bioorganic & Medicinal Chemistry Letters, 2012, Kumar, Santosh et. al.
A novel kind of nitrogen heterocycle compound induces apoptosis of human chronic myelogenous leukemia K562 cells
score: 1.2185219, Bioorganic & Medicinal Chemistry, 2006, Ding, Guoyu et. al.
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
score: 1.2185201, Antimicrobial agents and chemotherapy, 2001, Cruz, M C et. al.
Selective fluorescence quenching of the 8-oxoG-clamp by 8-oxodeoxyguanosine in ODN
score: 1.2185103, Bioorganic & Medicinal Chemistry Letters, 2009, Nasr, Tamer et. al.
Homology model of the multidrug transporter LmrA from Lactococcus lactis
score: 1.2185075, Bioorganic & Medicinal Chemistry Letters, 2004, Pleban, Karin et. al.
Hypervalent iodine mediated synthesis of 1-aryl/hetryl-1,2,4-triazolo[4,3- a] pyridines and 1-aryl/hetryl 5-methyl-1,2,4-triazolo[4,3- a]quinolines as antibacterial agents
score: 1.2184461, European Journal of Medicinal Chemistry, 2003, Sadana, Anil K.; Mirza, Yasmin; Aneja, Kamal R.; Prakash, Om
Treatment with a broad-spectrum cephalosporin versus piperacillin-tazobactam and the risk for isolation of broad-spectrum cephalosporin-resistant Enterobacter species.
score: 1.2184389, Antimicrobial agents and chemotherapy, 2003, Schwaber, Mitchell J et. al.
Efficacy of BAL5788, a prodrug of cephalosporin BAL9141, in a mouse model of acute pneumococcal pneumonia.
score: 1.2182824, Antimicrobial agents and chemotherapy, 2004, Azoulay-Dupuis, E et. al.
Elucidation of strict structural requirements of Brefeldin A as an inducer of differentiation and apoptosis
score: 1.2181393, Bioorganic & Medicinal Chemistry, 2000, Zhu, Ji-Wen et. al.
Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice.
score: 1.2181214, Antimicrobial agents and chemotherapy, 1999, De Sarro, A et. al.
Use of the chemical structure of peptides as the starting point to design nonpeptide agonists and antagonists at peptide receptors: Examples with cholecystokinin and tachykinins
score: 1.218091, Bioorganic & Medicinal Chemistry, 1996, Horwell, David C.
Arylguanidine and arylbiguanide binding at 5-HT 3 serotonin receptors: A QSAR study
score: 1.218085, Bioorganic & Medicinal Chemistry, 2003, Glennon, Richard A. et. al.
Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).
score: 1.2179357, Antimicrobial agents and chemotherapy, 2010, Warrilow, Andrew G S et. al.
MolShaCS: A free and open source tool for ligand similarity identification based on Gaussian descriptors
score: 1.2178461, European Journal of Medicinal Chemistry, 2013, Vaz de Lima, Luis Antônio C.; Nascimento, Alessandro S.
MolShaCS: A free and open source tool for ligand similarity identification based on Gaussian descriptors
score: 1.2178461, European Journal of Medicinal Chemistry, 2013, Vaz de Lima, Luis Antônio C.; Nascimento, Alessandro S.
A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests
score: 1.2178124, European Journal of Medicinal Chemistry, 2006, Rando, D.G. et. al.
Influences of methodological variables on susceptibility testing of caspofungin against Candida species and Aspergillus fumigatus.
score: 1.2177514, Antimicrobial agents and chemotherapy, 2003, Bartizal, C; Odds, F C
Increasing permeability of phospholipid bilayer membranes to alanine with synthetic α-aminophosphonate carriers
score: 1.2177457, Bioorganic & Medicinal Chemistry Letters, 2008, Danila, Delia C. et. al.
Synthesis and comparison of antiplasmodial activity of (+), (−) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline
score: 1.2176972, Bioorganic & Medicinal Chemistry, 2012, Rusconi, Chiara et. al.
Acquired gentamicin resistance by permeability impairment in Enterococcus faecalis.
score: 1.2176814, Antimicrobial agents and chemotherapy, 2006, Aslangul, Elisabeth et. al.
BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis.
score: 1.2176323, Antimicrobial agents and chemotherapy, 2002, Entenza, J M et. al.
Activity of HMR 3647 compared to those of six compounds against 235 strains of Enterococcus faecalis.
score: 1.217621, Antimicrobial agents and chemotherapy, 1999, Hoellman, D B; Lin, G; Jacobs, M R; Appelbaum, P C
Design, synthesis, and evaluation of α-ketoheterocycles as class C β-lactamase inhibitors
score: 1.2175754, Bioorganic & Medicinal Chemistry, 2001, Kumar, Sanjai; Pearson, Andre L.; Pratt, R.F.
Water-soluble polymer–drug conjugates for combination chemotherapy against visceral leishmaniasis
score: 1.2175058, Bioorganic & Medicinal Chemistry, 2010, Nicoletti, Salvatore; Seifert, Karin; Gilbert, Ian H.
Convenient synthesis of oligodeoxyribonucleotides bearing arabinofuranosyl pyrimidine derivatives and its duplex formation with complementary DNA
score: 1.2174822, Bioorganic & Medicinal Chemistry Letters, 2003, Ozaki, Hiroaki et. al.
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells
score: 1.2174124, Bioorganic & Medicinal Chemistry Letters, 2012, Juszczak, M. et. al.
Degradation of DNA by bisulfite treatment
score: 1.2172823, Bioorganic & Medicinal Chemistry Letters, 2007, Tanaka, Kazuo; Okamoto, Akimitsu
The Sequence-Activity Relationship between Metallo-β-Lactamases IMP-1, IMP-6, and IMP-25 Suggests an Evolutionary Adaptation to Meropenem Exposure.
score: 1.2172268, Antimicrobial agents and chemotherapy, 2012, Liu, Eleanor M; Pegg, Kevin M; Oelschlaeger, Peter
Comparative pharmacodynamics of gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa.
score: 1.2171543, Antimicrobial agents and chemotherapy, 2006, Tam, Vincent H et. al.
A bacteriophage lambda-based genetic screen for characterization of the activity and phenotype of the human immunodeficiency virus type 1 protease.
score: 1.2171119, Antimicrobial agents and chemotherapy, 2000, Martínez, M A et. al.
Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae.
score: 1.2170168, Antimicrobial agents and chemotherapy, 2003, Restrepo, M I et. al.
Attenuation of itraconazole fungicidal activity following preexposure of Aspergillus fumigatus to fluconazole.
score: 1.2169632, Antimicrobial agents and chemotherapy, 2003, Liu, Wei et. al.
Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin.
score: 1.2169459, Antimicrobial agents and chemotherapy, 2005, Chanteux, Hugues et. al.
Rapid cleavage of cyclic tertiary amides of Kemp's triacid: effects of ring structure
score: 1.2169434, Bioorganic & Medicinal Chemistry Letters, 2004, Dougan, Michael L et. al.
QSAR modelling of pancreatic β-cell K ATP channel openers R/ S-3,4-dihydro-2,2-dimethyl-6-halo-4-(substituted phenylaminocarbonylamino)-2 H-1-benzopyrans using MLR–FA techniques
score: 1.2169379, European Journal of Medicinal Chemistry, 2009, Alam, Sk. Mahasin et. al.
A convenient synthesis of 13N-labelled azo compounds: A new route for the preparation of amyloid imaging PET probes
score: 1.2166867, European Journal of Medicinal Chemistry, 2010, Gómez-Vallejo, Vanessa; Borrell, José I.; Llop, Jordi
A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.
score: 1.2166357, Antimicrobial agents and chemotherapy, 2000, Fiett, J et. al.
Glycolipids as immunostimulating agents
score: 1.2164579, Bioorganic & Medicinal Chemistry, 2008, Wu, Douglass; Fujio, Masakazu; Wong, Chi-Huey
Synthesis and biological properties of new α-methylene-γ-butyrolactones and α,β-unsaturated δ-lactones
score: 1.2163845, European Journal of Medicinal Chemistry, 2006, Cateni, Francesca et. al.
Synthesis and biological evaluation of scopoletin derivatives
score: 1.2163739, Bioorganic & Medicinal Chemistry, 2013, Cai, Xueting et. al.
Lysostaphin cream eradicates Staphylococcus aureus nasal colonization in a cotton rat model.
score: 1.2162278, Antimicrobial agents and chemotherapy, 2003, Kokai-Kun, John F et. al.
Comparative killing rates of fluoroquinolones and cell wall-active agents.
score: 1.2161067, Antimicrobial agents and chemotherapy, 2000, Fung-Tomc, J C et. al.
Investigating the Role of the Geminal Dimethyl Groups of Coenzyme A: Synthesis and Studies of a Didemethyl Analogue
score: 1.2160494, Bioorganic & Medicinal Chemistry, 2000, Vogel, Kurt W et. al.
Detection and control of aspartimide formation in the synthesis of cyclic peptides
score: 1.216031, Bioorganic & Medicinal Chemistry Letters, 2005, Flora, David et. al.
Reaction mechanisms of allicin and allyl-mixed disulfides with proteins and small thiol molecules
score: 1.2159713, European Journal of Medicinal Chemistry, 2010, Miron, Talia; Listowsky, Irving; Wilchek, Meir
Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium.
score: 1.2158954, Antimicrobial agents and chemotherapy, 2005, Tiuman, Tatiana Shioji et. al.
Peptides selected for binding to a virulent strain of Haemophilus influenzae by phage display are bactericidal.
score: 1.2158201, Antimicrobial agents and chemotherapy, 2005, Bishop-Hurley, Sharon L et. al.
A chromism-based assay (CHROBA) technique for in situ detection of protein kinase activity
score: 1.2158147, Bioorganic & Medicinal Chemistry Letters, 2005, Tomizaki, Kin-ya; Jie, Xu; Mihara, Hisakazu
Inhibitory activities of 11 antimicrobial agents and bactericidal activities of vancomycin and daptomycin against invasive methicillin-resistant Staphylococcus aureus isolates obtained from 1999 through 2006.
score: 1.2158131, Antimicrobial agents and chemotherapy, 2008, Holmes, Robert L; Jorgensen, James H
Biological applications of fullerenes
score: 1.2157935, Bioorganic & Medicinal Chemistry, 1996, Jensen, Anton W.; Wilson, Stephen R.; Schuster, David I.
Phosphinothricin tripeptide synthetases in Streptomyces viridochromogenes Tü494.
score: 1.2157502, Antimicrobial agents and chemotherapy, 2005, Schwartz, Dirk et. al.
Alkanethiol containing glycopolymers: A tool for the detection of lectin binding
score: 1.2157111, Bioorganic & Medicinal Chemistry Letters, 2007, Huang, Mingchuan et. al.
Novel fluorescent cephalosporins: Synthesis, antimicrobial activity and photodynamic inactivation of antibiotic resistant bacteria
score: 1.2156035, European Journal of Medicinal Chemistry, 2013, Xiao, Jian-Min et. al.
An efficient substitution reaction for the preparation of thyroid hormone analogues
score: 1.2155012, Bioorganic & Medicinal Chemistry, 1998, Yoshihara, Hikari A.I. et. al.
QSAR and ADME
score: 1.2154937, Bioorganic & Medicinal Chemistry, 2004, Hansch, Corwin et. al.
Biosynthesis of anti-HCV compounds using thermophilic microorganisms
score: 1.2154374, Bioorganic & Medicinal Chemistry Letters, 2012, Rivero, Cintia W. et. al.
Endothelin receptor antagonists: synthesis and structure–activity relationships of substituted benzothiazine-1,1-dioxides
score: 1.2153147, Bioorganic & Medicinal Chemistry, 1998, Berryman, K.A. et. al.
Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing 2′,4′- C-bridged 2′-deoxynucleosides
score: 1.2152217, Bioorganic & Medicinal Chemistry Letters, 1999, Wang, Guangyi et. al.
An approach toward the problem of outliers in QSAR
score: 1.2151866, Bioorganic & Medicinal Chemistry, 2005, Verma, Rajeshwar P.; Hansch, Corwin
8-17 DNAzyme modified with purine analogs in its catalytic core: the conservation of the five-membered moieties of purine residues
score: 1.2150415, Bioorganic & Medicinal Chemistry Letters, 2012, Rong, Wei et. al.
Tentacle type peptides as artificial lectins against sulfated Lewis X and A
score: 1.2150307, Bioorganic & Medicinal Chemistry Letters, 2008, Hyun, Soonsil; Lee, Eun Hye; Park, Jihye; Yu, Jaehoon
Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.
score: 1.2150242, Antimicrobial agents and chemotherapy, 2006, Cui, Longzhu et. al.
Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists
score: 1.2149797, Bioorganic & Medicinal Chemistry, 2012, Becknell, Nadine C. et. al.
Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists
score: 1.2149797, Bioorganic & Medicinal Chemistry, 2012, Becknell, Nadine C. et. al.
Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists
score: 1.2149797, Bioorganic & Medicinal Chemistry, 2012, Becknell, Nadine C. et. al.
In vitro activity of ramoplanin against Clostridium difficile, including strains with reduced susceptibility to vancomycin or with resistance to metronidazole.
score: 1.2149717, Antimicrobial agents and chemotherapy, 2005, Peláez, T et. al.
A strategy to profile prime and non-prime proteolytic substrate specificity
score: 1.2149612, Bioorganic & Medicinal Chemistry Letters, 2005, Petrassi, H. Michael et. al.
Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA
score: 1.2149554, Bioorganic & Medicinal Chemistry, 2012, Nanjunda, Rupesh et. al.
Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA
score: 1.2149554, Bioorganic & Medicinal Chemistry, 2012, Nanjunda, Rupesh et. al.
Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA
score: 1.2149554, Bioorganic & Medicinal Chemistry, 2012, Nanjunda, Rupesh et. al.
In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions.
score: 1.214942, Antimicrobial agents and chemotherapy, 2011, Stubbings, Will et. al.
Reduced pyrazinamidase activity and the natural resistance of Mycobacterium kansasii to the antituberculosis drug pyrazinamide.
score: 1.214904, Antimicrobial agents and chemotherapy, 1999, Sun, Z; Zhang, Y
The Conformation and Activity Relationship of Benzofuran Type of Angiotensin II Receptor Antagonists
score: 1.2148868, Bioorganic & Medicinal Chemistry, 2000, Yoo, Sung-eun et. al.
Structural polymorphism of human telomere G-quadruplex induced by a pyridyl carboxamide molecule
score: 1.2147961, Bioorganic & Medicinal Chemistry Letters, 2012, Xu, Liang; Xu, Zhouxin; Shang, Ye; Feng, Shuo; Zhou, Xiang
Three new 12-carbamoylated streptothricins from Streptomyces sp. I08A 1776
score: 1.2147803, Bioorganic & Medicinal Chemistry Letters, 2012, Gan, Maoluo et. al.
Design, synthesis, and pharmacological evaluation of some 2-[4-morpholino]-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: generation of a novel anti-inflammatory pharmacophore
score: 1.2147559, Bioorganic & Medicinal Chemistry, 2004, Pillai, Ajay D. et. al.
Anticonvulsant and toxicity evaluation of some 7-alkoxy-4,5-dihydro-[1,2,4]triazolo[4,3- a]quinoline-1(2 H)-ones
score: 1.214724, Bioorganic & Medicinal Chemistry, 2006, Jin, Hong-Guang et. al.
Synthesis and MAO-B Substrate Properties of 1-Methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines
score: 1.2146701, Bioorganic & Medicinal Chemistry, 1999, Yu, Jian; Castagnoli, Neal
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity
score: 1.2144782, Bioorganic & Medicinal Chemistry, 2004, Clader, John W et. al.
The preparation of ( S)-Aspartate semi-aldehyde appropriate for use in biochemical studies
score: 1.2144778, Bioorganic & Medicinal Chemistry Letters, 2003, Roberts, Sarah J et. al.
Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-Position. Part I: synthesis and biological activities of 3-(Benzothiazol-2-yl)thiocephalosporin derivatives, CP0467 and related compounds
score: 1.2144211, Bioorganic & Medicinal Chemistry, 1998, Tsushima, Masaki et. al.
An improved method for the synthesis of γ-DDB
score: 1.2143356, Bioorganic & Medicinal Chemistry Letters, 2010, Song, Chuanjun et. al.
Understanding the binding of daunorubicin and doxorubicin to NADPH-dependent cytosolic reductases by computational methods
score: 1.214318, European Journal of Medicinal Chemistry, 2012, Pirolli, Davide et. al.
Understanding the binding of daunorubicin and doxorubicin to NADPH-dependent cytosolic reductases by computational methods
score: 1.214318, European Journal of Medicinal Chemistry, 2012, Pirolli, Davide et. al.
Synthesis of a fluorescent 2′3′-dideoxycytosine analog, tCdd
score: 1.2142739, Bioorganic & Medicinal Chemistry Letters, 2009, Porterfield, William; Tahmassebi, Deborah C.
Lincomycin resistance gene lnu(D) in Streptococcus uberis.
score: 1.2142398, Antimicrobial agents and chemotherapy, 2008, Petinaki, Efthymia et. al.
Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives
score: 1.2142166, Bioorganic & Medicinal Chemistry, 2006, Stolze, Klaus et. al.
Prevention and treatment of virulent bacterial biofilms with an enzymatic nitric oxide-releasing dressing.
score: 1.2141647, Antimicrobial agents and chemotherapy, 2012, Sulemankhil, Imran et. al.
New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae)
score: 1.2141282, Bioorganic & Medicinal Chemistry, 1996, Fatope, Majekodunmi O. et. al.
Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity
score: 1.214115, European Journal of Medicinal Chemistry, 2003, Jansen, Michaela; Dannhardt, Gerd
Chemical synthesis of diastereomeric diadenosine boranophosphates (Ap bA) from 2′- O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method
score: 1.2140218, Bioorganic & Medicinal Chemistry, 2008, Enya, Yukiko et. al.
Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210
score: 1.2140061, Bioorganic & Medicinal Chemistry, 1997, Osada, Hiroyuki; Cui, Cheng-Bin; Onose, Rie; Hanaoka, Fumio
QSAR studies on benzopyran potassium channel activators
score: 1.2138464, European Journal of Medicinal Chemistry, 2006, Agrawal, Vijay K. et. al.
Susceptibilities of human cytomegalovirus clinical isolates to BAY38-4766, BAY43-9695, and ganciclovir.
score: 1.2137863, Antimicrobial agents and chemotherapy, 2001, McSharry, J J et. al.
Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum.
score: 1.21366, Antimicrobial agents and chemotherapy, 2000, Bellais, S; Aubert, D; Naas, T; Nordmann, P
Chemo-enzymatic synthesis of calcitonin derivatives containing N-linked oligosaccharides
score: 1.2135797, Bioorganic & Medicinal Chemistry Letters, 1998, Haneda, Katsuji et. al.
Topological modeling of benzodiazepine receptor binding
score: 1.2134971, Bioorganic & Medicinal Chemistry, 2003, Thakur, Abhilash; Thakur, Mamta; Khadikar, Padmakar
The design, synthesis and transmembrane transport studies of a biomimetic sterol-based ion channel
score: 1.2133806, Bioorganic & Medicinal Chemistry, 1997, Pechulis, Anthony D. et. al.
Assessment of malaria in vitro drug combination screening and mixed-strain infections using the malaria Sybr green I-based fluorescence assay.
score: 1.2130794, Antimicrobial agents and chemotherapy, 2009, Co, Edgie-Mark A et. al.
Simple fibroblast-based assay for screening of new antimicrobial drugs against Mycobacterium tuberculosis.
score: 1.2130743, Antimicrobial agents and chemotherapy, 2002, Takii, Takemasa et. al.
Site specific chemical delivery of NSAIDs to inflamed joints: Synthesis, biological activity and γ-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites
score: 1.2130512, Bioorganic & Medicinal Chemistry, 2008, Yadav, Mange Ram et. al.
Synthesis and biological evaluation of 2-Hydroxy derivatives of digitoxigenin and 3-Epidigitoxigenin 1 A preliminary account of this work has been presented at the First International Electronic Conference on Synthetic Organic Chemistry (ECSOC-1), A0012, 1–30 September 1997; http://www.mdpi.org/escoc-1.htm 1
score: 1.2130357, Bioorganic & Medicinal Chemistry, 1998, Gobbini, M et. al.
3′-Fluoro-3′-deoxy-5′-noraristeromycin derivatives: Synthesis and antiviral analysis
score: 1.2130157, Bioorganic & Medicinal Chemistry, 2006, Roy, Atanu; Serbessa, Tesfaye; Schneller, Stewart W.
Anthraquinone derivatives as a new family of protein photocleavers
score: 1.2130083, Bioorganic & Medicinal Chemistry Letters, 2005, Suzuki, Akane et. al.
Synthesis of multitopic neoglycopeptides displaying recognition and detection motifs
score: 1.2128856, Bioorganic & Medicinal Chemistry Letters, 2005, Renaudet, Olivier; Dumy, Pascal
Metabolism in human cells of the D and L enantiomers of the carbocyclic analog of 2'-deoxyguanosine: substrate activity with deoxycytidine kinase, mitochondrial deoxyguanosine kinase, and 5'-nucleotidase.
score: 1.2128419, Antimicrobial agents and chemotherapy, 1998, Bennett, L L et. al.
Synthesis and evaluation of curcumin-related compounds for anticancer activity
score: 1.2127974, European Journal of Medicinal Chemistry, 2012, Wei, Xingchuan et. al.
Synthesis and evaluation of curcumin-related compounds for anticancer activity
score: 1.2127974, European Journal of Medicinal Chemistry, 2012, Wei, Xingchuan et. al.
Synthesis and evaluation of curcumin-related compounds for anticancer activity
score: 1.2127974, European Journal of Medicinal Chemistry, 2012, Wei, Xingchuan et. al.
Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression 1 In honor of Professor Stuart Schreiber for his pioneering contributions to the interface between chemistry and biology. 1
score: 1.2127661, Bioorganic & Medicinal Chemistry, 1998, Turk, Benjamin E.; Su, Zhuang; Liu, Jun O.
Synthesis and biological activity of both enantiomers of kujigamberol isolated from 85-million-years-old Kuji amber
score: 1.2126041, Bioorganic & Medicinal Chemistry Letters, 2012, Ye, Yue Qi et. al.
Synthesis and biological activity of both enantiomers of kujigamberol isolated from 85-million-years-old Kuji amber
score: 1.2126041, Bioorganic & Medicinal Chemistry Letters, 2012, Ye, Yue Qi et. al.
Synthesis and biological activity of both enantiomers of kujigamberol isolated from 85-million-years-old Kuji amber
score: 1.2126041, Bioorganic & Medicinal Chemistry Letters, 2012, Ye, Yue Qi et. al.
Pheromone syntheses: A tropical approach. Enantioselective synthesis of the (2 R,6 S,10 S) and (2 S,6 S,10 S) isomers of methyl 2,6,10-trimethyldodecanoate
score: 1.2125715, Bioorganic & Medicinal Chemistry, 1996, Ferreira, J.Tércio B.; Zarbin, Paulo H.G.
ATP-phosphopeptide conjugates as inhibitors of Src tyrosine kinases
score: 1.2125356, Bioorganic & Medicinal Chemistry, 2004, Nam, Nguyen-Hai et. al.
The synthesis and antioxidant activity of the Schiff bases of chitosan and carboxymethyl chitosan
score: 1.2124919, Bioorganic & Medicinal Chemistry Letters, 2005, Guo, Zhanyong et. al.
A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA
score: 1.2124266, Bioorganic & Medicinal Chemistry Letters, 2010, Hagihara, Masaki et. al.
High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gene.
score: 1.2124014, Antimicrobial agents and chemotherapy, 2009, Jugheli, Levan et. al.
Comparative structure–activity relationships of benztropine analogues at the dopamine transporter and histamine H 1 receptors
score: 1.212236, Bioorganic & Medicinal Chemistry, 2006, Kulkarni, Santosh S. et. al.
Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
score: 1.2122219, Bioorganic & Medicinal Chemistry Letters, 2012, Ellanki, Amarender Reddy et. al.
Synthesis and antioxidant activity evaluation of novel antiparkinsonian agents, aminoadamantane derivatives of nitroxyl free radical
score: 1.2120857, Bioorganic & Medicinal Chemistry, 2003, Skolimowski, Janusz et. al.
Synthesis and evaluation of trans 3,4-cyclopropyl l-arginine analogues as isoform selective inhibitors of nitric oxide synthase
score: 1.2120688, Bioorganic & Medicinal Chemistry, 2003, Fishlock, Dan et. al.
Electrophilicity as a possible descriptor for toxicity prediction
score: 1.2119869, Bioorganic & Medicinal Chemistry, 2005, Roy, D.R. et. al.
Genetic structure associated with blaOXA-18, encoding a clavulanic acid-inhibited extended-spectrum oxacillinase.
score: 1.2118156, Antimicrobial agents and chemotherapy, 2008, Naas, Thierry et. al.
In vitro antileishmanial activity of nicotinamide.
score: 1.2118091, Antimicrobial agents and chemotherapy, 2005, Sereno, D et. al.
Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato-lanthanides
score: 1.2117391, European Journal of Medicinal Chemistry, 2013, Liu, Yan-Cheng et. al.
Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato-lanthanides
score: 1.2117391, European Journal of Medicinal Chemistry, 2013, Liu, Yan-Cheng et. al.
Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis
score: 1.2117252, Bioorganic & Medicinal Chemistry Letters, 2008, Li, Meng et. al.
Structure–activity relationship study of flavone compounds with anti-HIV-1 integrase activity: A density functional theory study
score: 1.2115568, Bioorganic & Medicinal Chemistry, 2006, Lameira, J. et. al.
Simple and rapid colorimetric detection of cofactors of aptazymes using noncrosslinking gold nanoparticle aggregation
score: 1.2113972, Bioorganic & Medicinal Chemistry Letters, 2008, Ogawa, Atsushi; Maeda, Mizuo
NODAPA-OH and NODAPA-(NCS) n : Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging
score: 1.2113023, Bioorganic & Medicinal Chemistry Letters, 2008, Riss, Patrick J. et. al.
Synthesis of a tetracyclic, conformationally constrained analogue of Δ 8-THC
score: 1.2112189, Bioorganic & Medicinal Chemistry, 1998, Huffman, John W.; Yu, Shu
Synthesis, aggregation, and neurotoxicity of the alzheimer's Aß1-42 amyloid peptide and its isoaspartyl isomers
score: 1.2111299, Bioorganic & Medicinal Chemistry Letters, 1999, Fukuda, Hiroyuki et. al.
Use of polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline for the preparation of a hapten–protein conjugate for antibody development
score: 1.2110674, Bioorganic & Medicinal Chemistry Letters, 2010, Sathe, Manisha et. al.
Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
score: 1.2108142, Antimicrobial agents and chemotherapy, 2009, Shi, Stephanie T et. al.
Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malaria.
score: 1.2107966, Antimicrobial agents and chemotherapy, 2007, Price, R N et. al.
Carboxylic acid and phosphate ester derivatives of fluconazole: synthesis and antifungal activities
score: 1.2107523, Bioorganic & Medicinal Chemistry, 2004, Nam, Nguyen-Hai et. al.
Synthesis and evaluation of mutual prodrugs of ibuprofen with menthol, thymol and eugenol
score: 1.2103641, European Journal of Medicinal Chemistry, 2012, Redasani, Vivekkumar K.; Bari, Sanjay B.
Synthesis and evaluation of mutual prodrugs of ibuprofen with menthol, thymol and eugenol
score: 1.2103641, European Journal of Medicinal Chemistry, 2012, Redasani, Vivekkumar K.; Bari, Sanjay B.
Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve
score: 1.2102216, European Journal of Medicinal Chemistry, 2012, Fernandes, Carla et. al.
CpG oligodeoxynucleotide 2006 and miltefosine, a potential combination for treatment of experimental visceral leishmaniasis.
score: 1.2099107, Antimicrobial agents and chemotherapy, 2011, Gupta, Suman et. al.
In vitro intracellular activity and in vivo efficacy of modithromycin, a novel bicyclolide, against Legionella pneumophila.
score: 1.2098916, Antimicrobial agents and chemotherapy, 2011, Sato, Takafumi et. al.
synthesis of new Δ 2-isoxazoline derivatives and their pharmacological characterization as β-adrenergic receptor antagonists
score: 1.2098838, Bioorganic & Medicinal Chemistry, 1998, Conti, Paola et. al.
Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone
score: 1.2098004, Bioorganic & Medicinal Chemistry, 2006, Stagliano, Kenneth W. et. al.
Efficacies of imipenem, meropenem, cefepime, and ceftazidime in rats with experimental pneumonia due to a carbapenem-hydrolyzing beta-lactamase-producing strain of Enterobacter cloacae.
score: 1.2097328, Antimicrobial agents and chemotherapy, 2000, Mimoz, O et. al.
In Vitro and In Vivo Activities of the Novel Ketolide RBx 14255 against Clostridium difficile.
score: 1.2096071, Antimicrobial agents and chemotherapy, 2012, Kumar, Manoj et. al.
Synthesis, cytotoxicity, DNA interaction and topoisomerase II inhibition properties of tetrahydropyrrolo[3,4- a]carbazole-1,3-dione and tetrahydropyrido-[3,2- b]pyrrolo[3,4- g]indole-1,3-dione derivatives
score: 1.2096028, Bioorganic & Medicinal Chemistry, 2001, Joseph, Benoı̂t et. al.
Caged Q-rhodamine dextran: a new photoactivated fluorescent tracer
score: 1.2094619, Bioorganic & Medicinal Chemistry Letters, 2001, Gee, Kyle R.; Weinberg, Eric S.; Kozlowski, David J.
Effects of α-tocopherol and related compounds on reactions involving various organic radicals
score: 1.2094603, Bioorganic & Medicinal Chemistry Letters, 2006, Povalishev, V.N.; Polozov, G.I.; Shadyro, O.I.
Staphylococcus aureus mutants isolated via exposure to nonfluorinated quinolones: detection of known and unique mutations.
score: 1.2093431, Antimicrobial agents and chemotherapy, 2001, Roychoudhury, S et. al.
Antiviral activity of lovastatin against respiratory syncytial virus in vivo and in vitro.
score: 1.2090913, Antimicrobial agents and chemotherapy, 2001, Gower, T L; Graham, B S
Efficacies of sordarin derivatives GM193663, GM211676, and GM237354 in a murine model of systemic coccidioidomycosis. p6.
score: 1.2088963, Antimicrobial agents and chemotherapy, 2000, Clemons, K V; Stevens, D A
Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from α-amino acids
score: 1.2088727, Bioorganic & Medicinal Chemistry Letters, 2000, Groarke, Michelle et. al.
In vivo antibacterial activity of RWJ-54428, a new cephalosporin with activity against gram-positive bacteria.
score: 1.2087516, Antimicrobial agents and chemotherapy, 2003, Griffith, David C et. al.
VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405.
score: 1.2086715, Antimicrobial agents and chemotherapy, 1999, Fines, M; Perichon, B; Reynolds, P; Sahm, D F; Courvalin, P
On designing non-saccharide, allosteric activators of antithrombin
score: 1.208621, European Journal of Medicinal Chemistry, 2009, Raghuraman, Arjun et. al.
Activities and time-kill studies of selected penicillins, beta-lactamase inhibitor combinations, and glycopeptides against Enterococcus faecalis.
score: 1.2085565, Antimicrobial agents and chemotherapy, 1998, Hoellman, D B; Visalli, M A; Jacobs, M R; Appelbaum, P C
Novel Cobalt Complex Inhibitors of Mitochondrial Calcium Uptake
score: 1.208517, Bioorganic & Medicinal Chemistry, 1999, Unitt, John F et. al.
Pyrrolidine based chiral organocatalyst for efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes
score: 1.208436, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Kamal Nain et. al.
Pyrrolidine based chiral organocatalyst for efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes
score: 1.208436, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Kamal Nain et. al.
Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC
score: 1.2084011, Bioorganic & Medicinal Chemistry, 2006, Pan, Po-Shen et. al.
Synthesis of novel vasodilatory active nicotinate esters with amino acid function
score: 1.2083786, Bioorganic & Medicinal Chemistry, 2006, Girgis, Adel S.; Kalmouch, Atef; Ellithey, Mohey
Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus.
score: 1.2082394, Antimicrobial agents and chemotherapy, 1997, Tanaka, M; Onodera, Y; Uchida, Y; Sato, K; Hayakawa, I
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity
score: 1.2081955, Bioorganic & Medicinal Chemistry, 1997, Micheli, Fabrizio et. al.
Evaluation of ligand-binding affinity using polynomial empirical scoring functions
score: 1.2081837, Bioorganic & Medicinal Chemistry, 2008, de Azevedo, Walter Filgueira; Dias, Raquel
Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.
score: 1.2080987, Bioorganic & Medicinal Chemistry Letters, 2012, Yamano, Yoshi; Arai, Masayoshi; Kobayashi, Motomasa
Enantioselective synthesis of (+)-8-hydroxy-8-methylidarubicinone
score: 1.2080465, Bioorganic & Medicinal Chemistry, 2004, Bourghli, Laurance M.S.; Stoodley, R.J.
Synthesis of structural analogues of leukotriene B 4 and their receptor binding activity
score: 1.2080238, Bioorganic & Medicinal Chemistry, 1997, Konno, Mitoshi et. al.
Synthesis of structural analogues of leukotriene B 4 and their receptor binding activity
score: 1.2080238, Bioorganic & Medicinal Chemistry, 1997, Konno, Mitoshi et. al.
Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis.
score: 1.2078869, Antimicrobial agents and chemotherapy, 1999, Phetsuksiri, B et. al.
Preparation of a tritiated ginkgolide
score: 1.2077266, Bioorganic & Medicinal Chemistry Letters, 2004, Strømgaard, Kristian; Suehiro, Makiko; Nakanishi, Koji
Efavirenz pharmacokinetics in cerebrospinal fluid and plasma over a 24-hour dosing interval.
score: 1.2077207, Antimicrobial agents and chemotherapy, 2012, Yilmaz, Aylin et. al.
Tri- and diorganotin(IV) complexes of biologically important orotic acid: Synthesis, spectroscopic studies,in vitroanti-cancer, DNA fragmentation, enzyme assays andin vivoanti-inflammatory activities
score: 1.2076509, European Journal of Medicinal Chemistry, 2013, Nath, Mala; Vats, Monika; Roy, Partha
Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group
score: 1.2075705, Bioorganic & Medicinal Chemistry Letters, 2000, Xia, Jie; Alderfer, James L.; Matta, Khushi L.
In Vitro Activities of Antibiotics and Antimicrobial Cationic Peptides Alone and in Combination against Methicillin-Resistant Staphylococcus aureus Biofilms.
score: 1.2074486, Antimicrobial agents and chemotherapy, 2012, Mataraci, Emel; Dosler, Sibel
pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada.
score: 1.2074271, Antimicrobial agents and chemotherapy, 2000, Cheng, S J; Thibert, L; Sanchez, T; Heifets, L; Zhang, Y
Inhibition of monoamine oxidase B by analogues of the adenosine A 2A receptor antagonist ( E)-8-(3-chlorostyryl)caffeine (CSC)
score: 1.2073293, Bioorganic & Medicinal Chemistry, 2006, Vlok, Nevil et. al.
Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus.
score: 1.2072606, Antimicrobial agents and chemotherapy, 2004, Durantel, David et. al.
Probing the altered specificity and catalytic properties of mutant subtilisin chemically modified at position S156C and S166C in the S 1 pocket
score: 1.2071711, Bioorganic & Medicinal Chemistry, 1999, DeSantis, Grace; Jones, J.Bryan
QSPR of 3-aryloxazolidin-2-one antibacterials
score: 1.207165, Bioorganic & Medicinal Chemistry, 2004, Katritzky, Alan R.; Fara, Dan C.; Karelson, Mati
Novel zinc finger nuclease created by combining the Cys 2His 2- and His 4-type zinc finger domains
score: 1.2071535, Bioorganic & Medicinal Chemistry Letters, 2009, Negi, Shigeru et. al.
Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
score: 1.2069336, Bioorganic & Medicinal Chemistry Letters, 2012, Morris, Kelly M. et. al.
Effect of recombinant murine granulocyte colony-stimulating factor with or without fluoroquinolone therapy on mixed-infection abscesses in mice.
score: 1.2069259, Antimicrobial agents and chemotherapy, 2005, Stearne, Lorna E T et. al.
Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobacterium bovis BCG and Staphylococcus aureus.
score: 1.206836, Antimicrobial agents and chemotherapy, 1999, Dong, Y; Zhao, X; Domagala, J; Drlica, K
Pharmacodynamic modeling of the evolution of levofloxacin resistance in Staphylococcus aureus.
score: 1.2067163, Antimicrobial agents and chemotherapy, 2005, Campion, Jeffrey J et. al.
In vitro activity of ceftaroline against methicillin-resistant Staphylococcus aureus and heterogeneous vancomycin-intermediate S. aureus in a hollow fiber model.
score: 1.2067116, Antimicrobial agents and chemotherapy, 2009, Vidaillac, Céline; Leonard, Steve N; Rybak, Michael J
Cocaine catalytic antibodies: the primary importance of linker effects
score: 1.2066328, Bioorganic & Medicinal Chemistry Letters, 2001, Matsushita, Masayuki et. al.
A comparative study of backbone versus side chain peptide cyclization: Application for HIV-1 integrase inhibitors
score: 1.2065849, Bioorganic & Medicinal Chemistry, 2012, Hayouka, Zvi et. al.
A comparative study of backbone versus side chain peptide cyclization: Application for HIV-1 integrase inhibitors
score: 1.2065849, Bioorganic & Medicinal Chemistry, 2012, Hayouka, Zvi et. al.
Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities
score: 1.206525, European Journal of Medicinal Chemistry, 2012, Sipos, Attila et. al.
Synthesis, properties, and photodynamic inactivation of Escherichia coli using a cationic and a noncharged Zn(II) pyridyloxyphthalocyanine derivatives
score: 1.20639, Bioorganic & Medicinal Chemistry, 2005, Scalise, Inés; Durantini, Edgardo N.
A flexizyme that selectively charges amino acids activated by a water-friendly leaving group
score: 1.2062882, Bioorganic & Medicinal Chemistry Letters, 2009, Niwa, Nobuyoshi et. al.
A quantitative structure–Activity relationship study on some sulfolanes and arylthiomethanes acting as HIV-1 protease inhibitors
score: 1.2062814, Bioorganic & Medicinal Chemistry, 1998, Gupta, S.P.; Babu, M.S.; Sowmya, S.
QSAR analysis of tyrosine kinase inhibitor using modified ant colony optimization and multiple linear regression
score: 1.206246, European Journal of Medicinal Chemistry, 2007, Shi, Wei-min; Shen, Qi; Kong, Wei; Ye, Bao-xian
Interactions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils.
score: 1.2061678, Antimicrobial agents and chemotherapy, 1998, Vazifeh, D; Preira, A; Bryskier, A; Labro, M T
Synthesis of biotinylated xestoquinone that retains inhibitory activity against Ca 2+ ATPase of skeletal muscle myosin
score: 1.2061634, Bioorganic & Medicinal Chemistry, 2003, Nakamura, Mitsuhiro et. al.
Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors
score: 1.2060999, Bioorganic & Medicinal Chemistry, 2003, Ishihara, Tsukasa et. al.
Effect of cholesterol on DMPC phospholipid membranes and QSAR model construction in membrane-interaction QSAR study through molecular dynamics simulation
score: 1.2060767, Bioorganic & Medicinal Chemistry, 2006, Liu, Jianzhong; Yang, Liu
Radical-regulating and antiviral properties of ascorbic acid and its derivatives
score: 1.2059513, Bioorganic & Medicinal Chemistry Letters, 2012, Brinkevich, Sviatoslav D. et. al.
In vitro antimycobacterial activities of capuramycin analogues.
score: 1.2058318, Antimicrobial agents and chemotherapy, 2008, Reddy, Venkata M; Einck, Leo; Nacy, Carol A
Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice.
score: 1.2058254, Antimicrobial agents and chemotherapy, 2000, Stoddart, C A et. al.
Characterization of the antiviral effect of 2',3'-dideoxy-2', 3'-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model.
score: 1.2057522, Antimicrobial agents and chemotherapy, 2000, Le Guerhier, F et. al.
Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines
score: 1.205744, European Journal of Medicinal Chemistry, 2003, Winum, Jean-Yves et. al.
A mixed resin bed for the quenching and purification of tetrabutylammonium fluoride mediated desilylating reactions
score: 1.2057031, Bioorganic & Medicinal Chemistry Letters, 1998, Parlow, John J.; Vazquez, Michael L.; Flynn, Daniel L.
Facile synthesis of β-Cyclodextrin dithiols
score: 1.2055851, Bioorganic & Medicinal Chemistry Letters, 2002, Yang, Jerry; Leung, David K
Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types.
score: 1.2055634, Antimicrobial agents and chemotherapy, 2002, Humeniuk, Christel et. al.
Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats.
score: 1.2055512, Antimicrobial agents and chemotherapy, 2004, D'Cruz, Osmond J; Waurzyniak, Barbara; Uckun, Fatih M
Standardized Comparison of the Relative Impacts of HIV-1 Reverse Transcriptase (RT) Mutations on Nucleoside RT Inhibitor Susceptibility.
score: 1.2052246, Antimicrobial agents and chemotherapy, 2012, Melikian, George L et. al.
Possible conformation of amphotericin B dimer in membrane-bound assembly as deduced from solid-state NMR
score: 1.205098, Bioorganic & Medicinal Chemistry, 2012, Umegawa, Yuichi et. al.
Studies of molecular mechanism of Tenofovir against 3TC- and AZT-resistance mutant HIV-1 reverse transcriptase
score: 1.2050173, Bioorganic & Medicinal Chemistry Letters, 2003, Chong, Youhoon; Akula, Nagaraju; Chu, Chung K
Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments
score: 1.2048595, Bioorganic & Medicinal Chemistry Letters, 2005, Sprinz, K. Ingrid; Tagore, Debarati M.; Hamilton, Andrew D.
Peptide deformylase as an antibacterial drug target: target validation and resistance development.
score: 1.2048499, Antimicrobial agents and chemotherapy, 2001, Apfel, C M et. al.
In vitro activity of the new ketolide telithromycin compared with those of macrolides against Streptococcus pyogenes: influences of resistance mechanisms and methodological factors.
score: 1.2048152, Antimicrobial agents and chemotherapy, 2000, Bemer-Melchior, P et. al.
Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates
score: 1.2048083, Bioorganic & Medicinal Chemistry Letters, 2005, Johansson, Dorte et. al.
N-(Trifluoromethyl)benzyl substituted N-Normetazocines and N-Norketobemidones
score: 1.2047904, Bioorganic & Medicinal Chemistry, 2003, May, Everette L et. al.
4,6-Dimethoxy-1,3,5-triazine oligoxyloglucans: Novel one-step preparable substrates for studying action of endo-β-1,4-glucanase III from Trichoderma reesei
score: 1.2047484, Bioorganic & Medicinal Chemistry Letters, 2010, Kobayashi, Atsushi et. al.
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth
score: 1.2045132, Bioorganic & Medicinal Chemistry, 2004, Ziegler, Hanne L et. al.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
score: 1.2044959, Antimicrobial agents and chemotherapy, 2004, Sáenz, Yolanda et. al.
Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-throughput format.
score: 1.2044759, Antimicrobial agents and chemotherapy, 2006, Cottier, Valérie; Barberis, Alcide; Lüthi, Urs
Insertion sequence ISEcp1B is involved in expression and mobilization of a bla(CTX-M) beta-lactamase gene.
score: 1.2044226, Antimicrobial agents and chemotherapy, 2003, Poirel, Laurent; Decousser, Jean-Winoc; Nordmann, Patrice
Chiral recognition by fluorescent chemosensors based on N-dansyl-amino acid-modified cyclodextrins
score: 1.2043641, Bioorganic & Medicinal Chemistry Letters, 2006, Ikeda, Hiroshi; Li, Qun; Ueno, Akihiko
Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide
score: 1.2043328, Bioorganic & Medicinal Chemistry Letters, 2005, Salhanick, Arthur I. et. al.
A novel bicyclic ketolide derivative
score: 1.2043298, Bioorganic & Medicinal Chemistry Letters, 2003, Zhao, Ying; You, Qidong; Shen, Wenbin
Synthesis of oligosaccharides corresponding to structures found in capsular polysaccharides of Cryptococcus neoformans—II
score: 1.2042979, Bioorganic & Medicinal Chemistry, 1996, Garegg, Per J.; Olsson, Lars; Oscarson, Stefan
Design, synthesis and structure–activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion
score: 1.2042869, European Journal of Medicinal Chemistry, 2012, Zhu, Zhibo et. al.
Design, synthesis and structure–activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion
score: 1.2042869, European Journal of Medicinal Chemistry, 2012, Zhu, Zhibo et. al.
Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis.
score: 1.2041968, Antimicrobial agents and chemotherapy, 2004, Cottagnoud, Philippe et. al.
5 H-pyrrolo[1,2- b][1,2,5]benzothiadiazepines (PBTDs): A novel class of non-nucleoside reverse transcriptase inhibitors
score: 1.2040955, Bioorganic & Medicinal Chemistry, 1996, Artico, Marino et. al.
Synthesis and biological activity of some new 5′- O-acyl tiazofurin derivatives
score: 1.2040565, European Journal of Medicinal Chemistry, 2006, Pejanović, Vjera et. al.
An enantioselective synthesis of insecticidal 4-alkynyloxazolines
score: 1.2040511, Bioorganic & Medicinal Chemistry, 2001, Clark, David; Travis, D.Andrew
The molecular mechanisms involved in the cytotoxicity of alkannin derivatives
score: 1.2040383, European Journal of Medicinal Chemistry, 2005, Wu, Hai-Qiang et. al.
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties
score: 1.2039434, Bioorganic & Medicinal Chemistry, 2003, Ilies, Monica et. al.
Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives
score: 1.2039177, Bioorganic & Medicinal Chemistry, 2002, Millet, Régis et. al.
NaCl improves siRNA delivery mediated by nanoparticles of hydroxyethylated cationic cholesterol with amido-linker
score: 1.2038507, Bioorganic & Medicinal Chemistry Letters, 2008, Hattori, Yoshiyuki et. al.
Synthesis of (−)-5,8-Dihydroxy-3 R-methyl-2 R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: An Inhibitor of β-Amyloid 1–42 Aggregation
score: 1.2037817, Bioorganic & Medicinal Chemistry, 2002, Parker, Michael H et. al.
Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product
score: 1.2037642, Bioorganic & Medicinal Chemistry Letters, 2009, Hayashi, Yujiro et. al.
C-Glycoside analogues of β-galactosylceramide with a simple ceramide substitute: Synthesis and binding to HIV-1 gp120
score: 1.2036893, Bioorganic & Medicinal Chemistry, 2006, Augustin, Line A.; Fantini, Jacques; Mootoo, David R.
A homology model of SERT based on the LeuT Aa template
score: 1.2036615, Bioorganic & Medicinal Chemistry Letters, 2006, Ravna, Aina Westrheim et. al.
A Simple Efficient Synthesis of [23,24]- 13C 2-Labeled Bile Salts as NMR Probes of Protein–Ligand Interactions
score: 1.203629, Bioorganic & Medicinal Chemistry Letters, 2002, Tochtrop, Gregory P. et. al.
Impact of a low-oxygen environment on the efficacy of antimicrobials against intracellular Chlamydia trachomatis.
score: 1.2035793, Antimicrobial agents and chemotherapy, 2011, Shima, Kensuke et. al.
Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.
score: 1.2034779, Antimicrobial agents and chemotherapy, 2001, Poirel, L et. al.
Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis.
score: 1.2034759, Antimicrobial agents and chemotherapy, 2000, Martineau, F et. al.
Synthesis and opioid activity of N,N-Dimethyl-Dmt-Tic-NH-CH(R)-R′ analogues: acquisition of potent δ antagonism
score: 1.2034486, Bioorganic & Medicinal Chemistry, 2003, Balboni, Gianfranco et. al.
Pharmacodynamic activity of amphotericin B deoxycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosis.
score: 1.2032937, Antimicrobial agents and chemotherapy, 2006, Wiederhold, Nathan P et. al.
Prevalence and molecular epidemiology of CTX-M extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals.
score: 1.203264, Antimicrobial agents and chemotherapy, 2003, Edelstein, M et. al.
A quantitative structure–activity relationship study on a novel class of calcium-entry blockers: 1-[{4-(aminoalkoxy)phenyl}sulphonyl]indolizines
score: 1.2031997, European Journal of Medicinal Chemistry, 2003, Gupta, S.P. et. al.
Synthesis of photoaffinity label analogues of α-tocopherol
score: 1.2031844, Bioorganic & Medicinal Chemistry Letters, 1998, Lei, Huangshu et. al.
Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers
score: 1.2031165, Bioorganic & Medicinal Chemistry, 2013, Mandawad, Gajanan G. et. al.
Screening a natural product-based combinatorial library using FTICR mass spectrometry
score: 1.2030781, Bioorganic & Medicinal Chemistry, 2006, Poulsen, Sally-Ann; Davis, Rohan A.; Keys, Timothy G.
Nucleosides and nucleotides. Part 226: Alternate-strand triple-helix formation by 3′-3′-linked oligodeoxynucleotides composed of asymmetrical sequences
score: 1.2030502, Bioorganic & Medicinal Chemistry Letters, 2004, Hoshika, Shuichi et. al.
Synthesis and pharmacology of the isomeric methylheptyl-Δ 8-tetrahydrocannabinols
score: 1.2029677, Bioorganic & Medicinal Chemistry, 1998, Huffman, John W. et. al.
Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa
score: 1.2028768, Bioorganic & Medicinal Chemistry, 2006, Yoshikawa, Masayuki et. al.
In vitro and in vivo activities of AM-112, a novel oxapenem.
score: 1.2028579, Antimicrobial agents and chemotherapy, 2003, Jamieson, Conor E; Lambert, Peter A; Simpson, Iain N
N-[ 18F]fluoroethyl-4-piperidyl acetate ([ 18F]FEtP4A)
score: 1.2028338, Bioorganic & Medicinal Chemistry, 2003, Zhang, Ming-Rong et. al.
Synthesis, and functional properties of a modified human insulin A-Chain: implication in a ‘Mini-Insulin’ structure determination
score: 1.2027479, Bioorganic & Medicinal Chemistry, 2002, Le Flem, Guillaume et. al.
Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers
score: 1.2026987, Bioorganic & Medicinal Chemistry, 2002, Caliendo, Giuseppe et. al.
Synthesis and biochemical application of 2′- O-methyl-3′-thioguanosine as a probe to explore group I intron catalysis
score: 1.2026857, Bioorganic & Medicinal Chemistry, 2008, Lu, Jun et. al.
Biomimetic oxidation of Hantzsch 1,4-dihydropyridines with tetra- n-butylammonium periodate catalyzed by tetraphenylporphyrinatomanganese(III) chloride [Mn(TPP)Cl]
score: 1.202618, Bioorganic & Medicinal Chemistry Letters, 2005, Nasr-Esfahani, Masoud et. al.
Anti-inflammatory and anti-arthritic effects of new synthetic 3-(4-hydroxyphenyl)-4-(4-thiomethoxyphenyl)-1H-pyrrole-2,5-dione
score: 1.2026013, Bioorganic & Medicinal Chemistry Letters, 2012, Shin, Ji-Sun et. al.
Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase.
score: 1.2025977, Antimicrobial agents and chemotherapy, 1998, Swedberg, G; Ringertz, S; Sköld, O
Effects of lipid constituents on membrane-permeabilizing activity of amphidinols
score: 1.2024049, Bioorganic & Medicinal Chemistry, 2008, Morsy, Nagy et. al.
Recombinant green fluorescent protein-expressing human cytomegalovirus as a tool for screening antiviral agents.
score: 1.2022051, Antimicrobial agents and chemotherapy, 2000, Marschall, M; Freitag, M; Weiler, S; Sorg, G; Stamminger, T
Biological and physicochemical properties of gemini quaternary ammonium compounds in which the positions of a cross-linking sulfur in the spacer differ
score: 1.2021716, European Journal of Medicinal Chemistry, 2005, Shirai, Akihiro et. al.
Synthesis of novel cholesterol-based cationic lipids for gene delivery
score: 1.202137, Bioorganic & Medicinal Chemistry Letters, 2009, Kim, Bieong-Kil et. al.
Active site binding modes of curcumin in HIV-1 protease and integrase
score: 1.2020757, Bioorganic & Medicinal Chemistry Letters, 2005, Vajragupta, Opa et. al.
Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance.
score: 1.2019712, Antimicrobial agents and chemotherapy, 2000, Williams, D L; Spring, L; Harris, E; Roche, P; Gillis, T P
Synthesis and biological evaluation of indazolo[4,3- bc][1,5]naphthyridines (10-aza-pyrazolo[3,4,5- kl]acridines): a new class of antitumor agents
score: 1.2019534, Bioorganic & Medicinal Chemistry, 2004, Magnano, Amelia et. al.
Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.
score: 1.2018141, Antimicrobial agents and chemotherapy, 2012, Andersen, Niels Møller et. al.
Library construction of neomycin–dipeptide heteroconjugates and selection against RRE RNA
score: 1.2018038, Bioorganic & Medicinal Chemistry, 2005, Ahn, Dae-Ro; Yu, Jaehoon
noncompetitive antagonist-binding sites of rat and housefly γ-aminobutyric acid receptors display different enantiospecificities for tert-butyl(isopropyl)bicyclophosphorothionate
score: 1.2017489, Bioorganic & Medicinal Chemistry, 2000, Ju, Xiu-Lian; Ozoe, Yoshihisa
Phase 2a study of the CCR5 monoclonal antibody PRO 140 administered intravenously to HIV-infected adults.
score: 1.2015125, Antimicrobial agents and chemotherapy, 2010, Jacobson, Jeffrey M et. al.
Synthesis of Solution-Phase Combinatorial Library of 4,6-Diamino-1,2-dihydro-1,3,5-triazine and Identification of New Leads Against A16V+S108T Mutant Dihydrofolate Reductase of Plasmodium falciparum
score: 1.2014812, Bioorganic & Medicinal Chemistry, 2003, Vilaivan, Tirayut et. al.
Selection of 5′-untranslated sequences that enhance initiation of translation in a cell-free protein synthesis system from wheat embryos
score: 1.2014109, Bioorganic & Medicinal Chemistry Letters, 2005, Kamura, Nami et. al.
Absolute stereochemistry and antitumor activity of iejimalides
score: 1.2013437, Bioorganic & Medicinal Chemistry, 2006, Nozawa, Kohei et. al.
Influence of carboxylic acid functionalities in ruthenium (II) polypyridyl complexes on DNA binding, cytotoxicity and antioxidant activity: Synthesis, structure andin vitroanticancer activity
score: 1.2012724, European Journal of Medicinal Chemistry, 2013, Sathiya Kamatchi, Thangavel et. al.
Structural comparison of 1 β-Methylcarbapenem, Carbapenem and Penem: NMR studies and theoretical calculations
score: 1.2012135, Bioorganic & Medicinal Chemistry, 1998, Nishimura, Tamiki et. al.
Aminoglycoside resistance with homogeneous and heterogeneous populations of antibiotic-resistant ribosomes.
score: 1.2011978, Antimicrobial agents and chemotherapy, 2001, Recht, M I; Puglisi, J D
Corrigendum to “ N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration” [Bioorg. Med. Chem. Lett. 19 (2009) 5078]
score: 1.200887, Bioorganic & Medicinal Chemistry Letters, 2010, Wakenhut, Florian et. al.
Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptococci and staphylococci.
score: 1.2007946, Antimicrobial agents and chemotherapy, 2002, Shortridge, Virginia D et. al.
Porphyrin conjugated to DNA by a 2′-amido-2′-deoxyuridine linkage
score: 1.2007808, Bioorganic & Medicinal Chemistry Letters, 2008, Sitaula, Sarita; Reed, Scott M.
Synthesis and antineoplastic activity of 2-alkylaminoethyl derivatives of various steroidal oximes
score: 1.200759, European Journal of Medicinal Chemistry, 2003, Jindal, Dharam Paul et. al.
In vivo efficacy of a human-simulated regimen of ceftaroline combined with NXL104 against extended-spectrum-beta-lactamase (ESBL)-producing and non-ESBL-producing Enterobacteriaceae.
score: 1.2006234, Antimicrobial agents and chemotherapy, 2011, Wiskirchen, Dora E et. al.
Dicarboxylic acid esters as transdermal permeation enhancers: Effects of chain number and geometric isomers
score: 1.200607, Bioorganic & Medicinal Chemistry Letters, 2009, Novotný, Michal et. al.
11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain
score: 1.2006036, Bioorganic & Medicinal Chemistry, 2004, Mukherjee, Jogeshwar et. al.
Effects of amoxicillin subinhibitory concentrations on the cross-protection developed by pneumococcal antibodies in mouse sepsis caused by an amoxicillin-resistant serotype 6B Streptococcus pneumoniae strain.
score: 1.2005761, Antimicrobial agents and chemotherapy, 2004, Tarragó, D; Aguilar, L; Giménez, M J; Fenoll, A; Casal, J
A dual lanthanide probe suitable for optical (Tb 3+ luminescence) and magnetic resonance imaging (Gd 3+ relaxometry)
score: 1.2005674, Bioorganic & Medicinal Chemistry Letters, 2006, Picard, Claude et. al.
In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives.
score: 1.2005412, Antimicrobial agents and chemotherapy, 2005, Robledo, Sara et. al.
Application of genetic algorithm-support vector machine (GA-SVM) for prediction of BK-channels activity
score: 1.2005246, European Journal of Medicinal Chemistry, 2009, Pourbasheer, Eslam et. al.
Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus.
score: 1.200476, Antimicrobial agents and chemotherapy, 2005, Fujimoto-Nakamura, Mika et. al.
Synthesis of new glycyrrhetinic acid (GA) derivatives and their effects on tyrosinase activity
score: 1.2004233, Bioorganic & Medicinal Chemistry, 2003, Um, Soo-Jong et. al.
Redox potentials, laccase oxidation, and antilarval activities of substituted phenols
score: 1.2004189, Bioorganic & Medicinal Chemistry, 2012, Prasain, Keshar et. al.
GRIND/ALMOND investigations on CysLT 1 receptor antagonists of the quinolinyl(bridged)aryl type
score: 1.2003677, Bioorganic & Medicinal Chemistry, 2004, Benedetti, Paolo et. al.
Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci.
score: 1.2002726, Antimicrobial agents and chemotherapy, 2005, Chesneau, Olivier et. al.
Effects of positively selected sequence variations in human and Macaca fascicularis beta-defensins 2 on antimicrobial activity.
score: 1.2001837, Antimicrobial agents and chemotherapy, 2004, Antcheva, Nikolinka et. al.
A novel carbon monoxide-releasing molecule fully protects mice from severe malaria.
score: 1.2001472, Antimicrobial agents and chemotherapy, 2012, Pena, Ana C et. al.
Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl carbamate analogs as σ 2 receptor ligands
score: 1.20007, Bioorganic & Medicinal Chemistry, 2006, Vangveravong, Suwanna et. al.
Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis.
score: 1.2000629, Antimicrobial agents and chemotherapy, 2000, Murphy, T M et. al.
Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.
score: 1.2000533, Antimicrobial agents and chemotherapy, 2004, Smilkstein, Martin et. al.
Interaction of isofraxidin with human serum albumin
score: 1.1999887, Bioorganic & Medicinal Chemistry, 2004, Liu, Jiaqin et. al.
Biochemical-genetic characterization and distribution of OXA-22, a chromosomal and inducible class D beta-lactamase from Ralstonia (Pseudomonas) pickettii.
score: 1.1999001, Antimicrobial agents and chemotherapy, 2000, Nordmann, P; Poirel, L; Kubina, M; Casetta, A; Naas, T
The new generation dihydropyridine type calcium blockers, bearing 4-phenyl oxypropanolamine, display α-/β-Adrenoceptor antagonist and long-Acting antihypertensive activities
score: 1.1998672, Bioorganic & Medicinal Chemistry, 2002, Liang, Jhy-Chong et. al.
Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives
score: 1.1997875, Bioorganic & Medicinal Chemistry, 2012, Barros, Francisco W.A. et. al.
Phosphorylated 1,6-diphenyl-1,3,5-hexatriene
score: 1.199719, Bioorganic & Medicinal Chemistry Letters, 2004, Ma, Ling et. al.
Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients.
score: 1.1996842, Antimicrobial agents and chemotherapy, 2011, Pai, Manjunath P; Nafziger, Anne N; Bertino, Joseph S
Identification, synthesis and bioassay for the metabolites of P6A
score: 1.1996506, Bioorganic & Medicinal Chemistry, 2003, Zhao, Ming et. al.
Fluorescence generation from tandem repeats of a malachite green RNA aptamer using rolling circle transcription
score: 1.1994554, Bioorganic & Medicinal Chemistry Letters, 2008, Furukawa, Kazuhiro et. al.
Protein-dynamics of the putative HCV receptor CD81 large extracellular loop
score: 1.1994423, Bioorganic & Medicinal Chemistry Letters, 2004, Neugebauer, Alexander et. al.
Activity of oritavancin (LY333328), an investigational glycopeptide, compared to that of vancomycin against multidrug-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic model.
score: 1.1993754, Antimicrobial agents and chemotherapy, 2001, Coyle, E A; Rybak, M J
A novel orally active inhibitor of HLE
score: 1.1993166, European Journal of Medicinal Chemistry, 2003, Varga, Márton et. al.
Insect neuropeptides: Structures, chemical modifications and potential for insect control
score: 1.1992267, Bioorganic & Medicinal Chemistry, 2009, Scherkenbeck, Jürgen; Zdobinsky, Tino
A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs.
score: 1.1992257, Antimicrobial agents and chemotherapy, 1998, Hertogs, K et. al.
Versatile approach for the synthesis of novel seven-membered iminocyclitols via ring-closing metathesis dihydroxylation reaction
score: 1.1992061, Bioorganic & Medicinal Chemistry, 2004, Lin, Chang-Ching et. al.
Design, synthesis, and antitumor evaluation of novel acenaphtho[1,2- b]pyrrole-carboxylic acid esters with amino chain substitution
score: 1.1990642, Bioorganic & Medicinal Chemistry, 2006, Liu, Fengyu et. al.
bla(VIM-2) cassette-containing novel integrons in metallo-beta-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital.
score: 1.1990635, Antimicrobial agents and chemotherapy, 2002, Lee, Kyungwon et. al.
Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones
score: 1.1990452, Bioorganic & Medicinal Chemistry, 2001, Stephens, Chad E et. al.
Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins.
score: 1.198994, Antimicrobial agents and chemotherapy, 2005, Maligie, Marybeth A; Selitrennikoff, Claude P
The role of backbone conformation in deltorphin II binding: A QSAR study of new analogues modified in the 5-, 6-positions of the address domain
score: 1.1989925, Bioorganic & Medicinal Chemistry, 2001, Schullery, Stephen E et. al.
A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II.
score: 1.198906, Antimicrobial agents and chemotherapy, 2004, Gruger, Thomas et. al.
Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer.
score: 1.1988661, Antimicrobial agents and chemotherapy, 2006, Lin, Chin-chung et. al.
The cytotoxic activity of ursolic acid derivatives
score: 1.1987701, European Journal of Medicinal Chemistry, 2005, Ma, Chao-Mei et. al.
Structural studies on McN-5652-X, a high-affinity ligand for the serotonin transporter in mammalian brain
score: 1.1987304, Bioorganic & Medicinal Chemistry, 2003, Maryanoff, Bruce E et. al.
Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320.
score: 1.1985885, Antimicrobial agents and chemotherapy, 1998, Stoddart, C A et. al.
Enzymatic hydrolysis of stampidine and other stavudine phosphoramidates in the presence of mammalian proteases
score: 1.1985815, Bioorganic & Medicinal Chemistry, 2005, Venkatachalam, T.K.; Samuel, P.; Uckun, F.M.
Occurrence of a Salmonella enterica serovar typhimurium DT104-like antibiotic resistance gene cluster including the floR gene in S. enterica serovar agona.
score: 1.1985753, Antimicrobial agents and chemotherapy, 2000, Cloeckaert, A et. al.
Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides
score: 1.1985745, Bioorganic & Medicinal Chemistry, 2005, Sarabia, Francisco; Sánchez-Ruiz, Antonio; Chammaa, Samy
Total synthesis of mololipids: A new series of anti-HIV Moloka'iamine derivatives
score: 1.1983193, Bioorganic & Medicinal Chemistry Letters, 2000, Schoenfeld, Ryan C. et. al.
Chemoenzymatic synthesis and evaluation of 3-azabicyclo[3.2.0]heptane derivatives as dopaminergic ligands
score: 1.1982105, European Journal of Medicinal Chemistry, 2012, Reinart-Okugbeni, Reet et. al.
Contrasting effects of physical wear on elution of two antibiotics from orthopedic cement.
score: 1.1981807, Antimicrobial agents and chemotherapy, 2012, Dodds, S et. al.
Candidate polyanionic microbicides inhibit human T-cell lymphotropic virus type 1 receptor interactions, cell-free infection, and cell-cell spread.
score: 1.1981727, Antimicrobial agents and chemotherapy, 2009, Romer, Daniela et. al.
In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.
score: 1.1981591, Antimicrobial agents and chemotherapy, 2011, Desgranges, Stephane et. al.
Antipneumococcal activity of ertapenem (MK-0826) compared to those of other agents.
score: 1.1979091, Antimicrobial agents and chemotherapy, 2002, Pankuch, Glenn A et. al.
Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes
score: 1.1978822, European Journal of Medicinal Chemistry, 2006, Gündoğdu-Karaburun, Nalan et. al.
Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]
score: 1.1978449, Bioorganic & Medicinal Chemistry Letters, 2010, Robarge, Kirk D. et. al.
N-Acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity.
score: 1.1977878, Antimicrobial agents and chemotherapy, 1999, Wakabayashi, H et. al.
Synthesis, structure and anticancer activity of novel 2,4-diamino-1,3,5-triazine derivatives
score: 1.1977732, European Journal of Medicinal Chemistry, 2006, Sączewski, F.; Bułakowska, A.; Bednarski, P.; Grunert, R.
Chaperone-like activity of the acute-phase component human serum α 1-acid glycoprotein: Inhibition of thermal- and chemical-induced aggregation of various proteins
score: 1.1977394, Bioorganic & Medicinal Chemistry Letters, 2010, Zsila, Ferenc
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.
score: 1.19771, Antimicrobial agents and chemotherapy, 2003, Urbina, Julio A et. al.
Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio.
score: 1.1975851, Antimicrobial agents and chemotherapy, 2011, Endimiani, Andrea et. al.
Condensed E. coli cultures for highly efficient production of proteins containing unnatural amino acids
score: 1.1975109, Bioorganic & Medicinal Chemistry Letters, 2010, Liu, Jia et. al.
Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl-Δ 8-tetrahydrocannabinols: New selective ligands for the CB 2 receptor
score: 1.197482, Bioorganic & Medicinal Chemistry, 2006, Huffman, John W. et. al.
Antianaerobic activity of a novel fluoroquinolone, WCK 771, compared to those of nine other agents.
score: 1.1974273, Antimicrobial agents and chemotherapy, 2004, Peric, Mihaela; Jacobs, Michael R; Appelbaum, Peter C
Detection of protein–Ligand interaction on the membranes using C-Terminus biotin-Tagged alamethicin
score: 1.1974189, Bioorganic & Medicinal Chemistry, 2002, Zhang, Y.; Futaki, Shiroh; Kiwada, Tatsuto; Sugiura, Yukio
Novel aspects of interaction between UDP-Gal and GlcNAc β-1,4-Galactosyltransferase: Transferability and remarkable inhibitory activity of UDP-(mono- O-methylated Gal), UDP-Fuc and UDP-Man
score: 1.197412, Bioorganic & Medicinal Chemistry, 1996, Endo, Tsuyoshi et. al.
Possible allosteric effects in anticancer compounds
score: 1.1973693, Bioorganic & Medicinal Chemistry, 2001, Garg, Rajni; Kurup, Alka; Hansch, Corwin
Quantitative structure–activity relationships for the pre-steady-state inhibition of cholesterol esterase by 4-nitrophenyl- n-substituted carbamates
score: 1.1973198, Bioorganic & Medicinal Chemistry, 2000, Lin, Gialih; Liao, Wei-Cheng; Chiou, Shyh-Ying
A novel kind of antitumour drugs using sulfonamide as parent compound
score: 1.1971404, European Journal of Medicinal Chemistry, 2001, Huang, Zhaohua; Lin, Zhaoliang; Huang, Junlian
Optimization of a pharmacophore model for 5-HT 4 agonists using CoMFA and receptor based alignment
score: 1.1969874, European Journal of Medicinal Chemistry, 2006, Iskander, Magdy N. et. al.
In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods.
score: 1.1969642, Antimicrobial agents and chemotherapy, 2011, Pfaller, Michael A et. al.
Microbial and reducing agents catalyze the rearrangement of taxanes
score: 1.1969114, Bioorganic & Medicinal Chemistry, 2001, Sun, Di-An et. al.
Anidulafungin pharmacokinetics and microbial response in neutropenic mice with disseminated candidiasis.
score: 1.196834, Antimicrobial agents and chemotherapy, 2006, Gumbo, Tawanda et. al.
Structure-activity relationship of a new class of anti-hepatitis B virus agents.
score: 1.1967354, Antimicrobial agents and chemotherapy, 2002, Mehta, Anand et. al.
NDM-4 metallo-β-lactamase with increased carbapenemase activity from Escherichia coli.
score: 1.1967053, Antimicrobial agents and chemotherapy, 2012, Nordmann, Patrice; Boulanger, Anne E; Poirel, Laurent
The maltose ABC transporter in Lactococcus lactis facilitates high-level sensitivity to the circular bacteriocin garvicin ML.
score: 1.1966217, Antimicrobial agents and chemotherapy, 2012, Gabrielsen, Christina et. al.
Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm.
score: 1.1966165, Antimicrobial agents and chemotherapy, 2010, Suci, Peter et. al.
Oritavancin population pharmacokinetics in healthy subjects and patients with complicated skin and skin structure infections or bacteremia.
score: 1.1965996, Antimicrobial agents and chemotherapy, 2009, Rubino, Christopher M et. al.
DNA sequence recognition in the minor groove by hairpin pyrrole polyamide–Hoechst 33258 analogue conjugate
score: 1.1965962, Bioorganic & Medicinal Chemistry Letters, 2004, Reddy, Putta Mallikarjuna; Dexter, Rachel; Bruice, Thomas C
Identification of thioether intermediates in the reductive transformation of gonyautoxins into saxitoxins by thiols
score: 1.196578, Bioorganic & Medicinal Chemistry Letters, 2000, Sato, Shigeru; Sakai, Ryuichi; Kodama, Masaaki
In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates
score: 1.196362, Bioorganic & Medicinal Chemistry, 2012, Dang, Hung The et. al.
Tripartate poly(ethylene glycol) prodrugs of the open lactone form of camptothecin
score: 1.1962909, Bioorganic & Medicinal Chemistry, 2003, Greenwald, Richard B; Zhao, Hong; Xia, Jing
Synthesis of novel progestin–rhenium conjugates as potential ligands for the progesterone receptor
score: 1.196256, Bioorganic & Medicinal Chemistry, 1999, Wüst, F. et. al.
Population pharmacokinetics of ciprofloxacin in pediatric and adolescent patients with acute infections.
score: 1.1962239, Antimicrobial agents and chemotherapy, 2003, Payen, S et. al.
In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus.
score: 1.1961553, Antimicrobial agents and chemotherapy, 2009, Singh, Shveta Rani et. al.
Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups
score: 1.1960111, Bioorganic & Medicinal Chemistry, 2005, Li, Zhigang; Yang, Qing; Qian, Xuhong
Photoactive porphyrin derivative with broad-spectrum activity against oral pathogens In vitro.
score: 1.1959714, Antimicrobial agents and chemotherapy, 2000, Rovaldi, C R et. al.
How to blast osteoblasts? Novel dicarba analogues of amylin-(1–8) to treat osteoporosis
score: 1.1959159, Bioorganic & Medicinal Chemistry, 2012, Kowalczyk, Renata et. al.
Synthesis of oligodeoxynucleotides incorporating 2- N-carbamoylguanine and evaluation of the hybridization properties
score: 1.1958632, Bioorganic & Medicinal Chemistry, 2009, Sasami, Takeshi et. al.
Alternative oxidase inhibitors potentiate the activity of atovaquone against Plasmodium falciparum.
score: 1.1958194, Antimicrobial agents and chemotherapy, 1999, Murphy, A D; Lang-Unnasch, N
In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon.
score: 1.1958089, Antimicrobial agents and chemotherapy, 2003, Basco, Leonardo K; Ringwald, Pascal
Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering? An investigation of the advantages and pitfalls of post-filtering
score: 1.1955944, Journal of Molecular Graphics and Modelling, 2008, Muthas, Daniel et. al.
Molecular characterization of vanB elements in naturally occurring gut anaerobes.
score: 1.1955198, Antimicrobial agents and chemotherapy, 2005, Ballard, S A et. al.
Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates from England and Wales reveals the phylogenetic significance of the ahpC -46A polymorphism.
score: 1.1954468, Antimicrobial agents and chemotherapy, 2005, Baker, L V et. al.
Synthesis of 4-hydroxy-1-methylindole and benzo[ b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents
score: 1.1952832, Bioorganic & Medicinal Chemistry, 2005, Yadav, Prem P. et. al.
Electrospray ionization mass spectroscopic analysis of peptides modified with N-ethylmaleimide or iodoacetanilide
score: 1.1952468, Bioorganic & Medicinal Chemistry Letters, 2008, Zabet-Moghaddam, Masoud et. al.
Synthesis of 2′,3′-dideoxy-2′-monofluoromethyl azanucleosides
score: 1.1951921, Bioorganic & Medicinal Chemistry, 2005, Qiup, Xiao-Long; Qing, Feng-Ling
Exposure-response analyses of tigecycline efficacy in patients with complicated intra-abdominal infections.
score: 1.1951634, Antimicrobial agents and chemotherapy, 2008, Passarell, J A et. al.
Synergy with rifampin and kanamycin enhances potency, kill kinetics, and selectivity of de novo-designed antimicrobial peptides.
score: 1.1950856, Antimicrobial agents and chemotherapy, 2010, Anantharaman, Aparna; Rizvi, Meryam Sardar; Sahal, Dinkar
Relationship between the lipophilicity of gallic acid n-alquil esters’ derivatives and both myeloperoxidase activity and HOCl scavenging
score: 1.1950085, Bioorganic & Medicinal Chemistry, 2006, Rosso, Rober et. al.
Conversion of cyclic nonaketides to lovastatin and compactin by a lovc deficient mutant of Aspergillus terreus
score: 1.1949868, Bioorganic & Medicinal Chemistry Letters, 2001, Auclair, Karine et. al.
Cefepime-aztreonam: a unique double beta-lactam combination for Pseudomonas aeruginosa.
score: 1.1949552, Antimicrobial agents and chemotherapy, 1998, Lister, P D; Sanders, W E; Sanders, C C
Parallel-compound synthesis: Methodology for accelerating drug discovery
score: 1.1949387, Bioorganic & Medicinal Chemistry, 1996, Selway, Christopher N.; Terrett, Nicholas K.
Interesting reaction of the indanone oximes under Beckmann rearrangement conditions
score: 1.1948986, Bioorganic & Medicinal Chemistry Letters, 2002, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cells
score: 1.1948441, Bioorganic & Medicinal Chemistry, 2005, Du, Ai-Ying et. al.
On the use of 2,1,3-benzothiadiazole derivatives as selective live cell fluorescence imaging probes
score: 1.1947911, Bioorganic & Medicinal Chemistry Letters, 2010, Oliveira, Felipe F.D. et. al.
Fluorometric assay for tissue transglutaminase-mediated transamidation activity
score: 1.1947327, Bioorganic & Medicinal Chemistry, 2009, Gnaccarini, Claudio et. al.
Quinones as antimycobacterial agents
score: 1.1946187, Bioorganic & Medicinal Chemistry, 2004, Tran, Thuyanh et. al.
Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives
score: 1.1944719, Bioorganic & Medicinal Chemistry, 1997, Lien, Jin-Cherng et. al.
Diaryldimethylpiperazine ligands with μ- and δ-opioid receptor affinity: Synthesis of (+)-4-[(α R)-α-(4-allyl-(2 S,5 S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]- N-ethyl- N-phenylbenzamide and (−)-4-[(α R)-α-(2 S,5 S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]- N-ethyl- N-phenylbenzamide
score: 1.1944708, Bioorganic & Medicinal Chemistry, 2003, Kim, In Jong et. al.
Site-specific mutation of Staphylococcus aureus VraS reveals a crucial role for the VraR-VraS sensor in the emergence of glycopeptide resistance.
score: 1.1943598, Antimicrobial agents and chemotherapy, 2011, Galbusera, Elena et. al.
Self-aggregation of synthetic zinc chlorophyll derivative possessing a perfluoroalkyl group in a fluorinated solvent
score: 1.194335, Bioorganic & Medicinal Chemistry, 2006, Shibata, Reiko; Tamiaki, Hitoshi
Origin and evolution of the AmpC beta-lactamases of Citrobacter freundii.
score: 1.194281, Antimicrobial agents and chemotherapy, 2002, Barlow, Miriam; Hall, Barry G
Telavancin in Therapy of Experimental Aortic Valve Endocarditis in Rabbits Due to Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus.
score: 1.1942213, Antimicrobial agents and chemotherapy, 2012, Xiong, Yan Q et. al.
Development of CoMFA, advance CoMFA and CoMSIA models in pyrroloquinazolines as thrombin receptor antagonist
score: 1.1941895, Bioorganic & Medicinal Chemistry, 2004, Dixit, Anshuman et. al.
Syntheses of Polycationic Dendrimers on Lipophilic Peptide Core for Complexation and Transport of Oligonucleotides
score: 1.194136, Bioorganic & Medicinal Chemistry Letters, 2002, Wimmer, Norbert et. al.
ω-Pyridiniumalkylethers of steroidal phenols: new compounds with potent antibacterial and antiproliferative activities
score: 1.194133, Bioorganic & Medicinal Chemistry, 2004, Lange, C et. al.
Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation
score: 1.1941083, European Journal of Medicinal Chemistry, 2012, Kumar, Kewal et. al.
Experimental and ‘in silico’ analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups
score: 1.1940698, Bioorganic & Medicinal Chemistry, 2012, Domínguez, José L. et. al.
A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B 6-Derived zinc-Chelating trioxa-adamantane-triol
score: 1.1940066, Bioorganic & Medicinal Chemistry, 2003, Kesel, Andreas J
Efficacy of amphotericin B in combination with flucytosine against flucytosine-susceptible or flucytosine-resistant isolates of Cryptococcus neoformans during disseminated murine cryptococcosis.
score: 1.193966, Antimicrobial agents and chemotherapy, 2006, Schwarz, Patrick et. al.
Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities
score: 1.1936672, European Journal of Medicinal Chemistry, 2009, Suksrichavalit, Thummaruk et. al.
Precursor-directed biosynthesis of 12-ethyl erythromycin
score: 1.1936615, Bioorganic & Medicinal Chemistry, 1998, Jacobsen, John R et. al.
Genetic and Biochemical Characterization of an Acquired Subgroup B3 Metallo-β-Lactamase Gene, blaAIM-1, and Its Unique Genetic Context in Pseudomonas aeruginosa from Australia.
score: 1.1936458, Antimicrobial agents and chemotherapy, 2012, Yong, Dongeun et. al.
Cell wall composition and decreased autolytic activity and lysostaphin susceptibility of glycopeptide-intermediate Staphylococcus aureus.
score: 1.1936173, Antimicrobial agents and chemotherapy, 2004, Koehl, Jennifer L et. al.
Flow chemistry using milli- and microstructured reactors—From conventional to novel process windows
score: 1.193617, Bioorganic & Medicinal Chemistry, 2010, Illg, Tobias; Löb, Patrick; Hessel, Volker
Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product
score: 1.1932183, Bioorganic & Medicinal Chemistry, 2005, Runyon, Scott P. et. al.
Downregulation of Mitogen-Activated Protein Kinase 1 of Leishmania donovani Field Isolates Is Associated with Antimony Resistance.
score: 1.1931568, Antimicrobial agents and chemotherapy, 2012, Ashutosh, et. al.
Baylis–Hillman Reaction: Convenient Ascending Syntheses and Biological Evaluation of Acyclic Deoxy Monosaccharides as Potential Antimycobacterial Agents
score: 1.1931443, Bioorganic & Medicinal Chemistry, 2002, Pathak, Rashmi et. al.
Synthesis and biological evaluation of 1β-methylcarbapenems having cyclic thiourea moieties and their related compounds
score: 1.1930372, European Journal of Medicinal Chemistry, 2006, Han, T.; Cho, J.-H.; Oh, C.-H.
Italian survey on comparative levofloxacin susceptibility in 334 clinical isolates of Pseudomonas aeruginosa.
score: 1.1930023, Antimicrobial agents and chemotherapy, 1999, Segatore, B et. al.
A QSAR study on influenza neuraminidase inhibitors
score: 1.1929795, Bioorganic & Medicinal Chemistry, 2006, Verma, Rajeshwar P.; Hansch, Corwin
Solid-Phase Synthesis of DNA Binding Polyamides on Oxime Resin
score: 1.19294, Bioorganic & Medicinal Chemistry, 2002, Belitsky, J.M; Nguyen, D.H; Wurtz, N.R; Dervan, Peter B
Topological estimation of electronic absorption bands of arene absorption spectra as a tool for modeling their toxicity and environmental pollution
score: 1.1928504, Bioorganic & Medicinal Chemistry Letters, 2004, Khadikar, Padmakar V. et. al.
Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores.
score: 1.1928248, Antimicrobial agents and chemotherapy, 2000, Kurosawa, Y et. al.
Valacyclovir for herpes simplex encephalitis.
score: 1.19279, Antimicrobial agents and chemotherapy, 2011, Pouplin, Thomas et. al.
Design and chemoenzymatic synthesis of thiooligosaccharide inhibitors of 1,3:1,4-β- d-glucanases
score: 1.19274, Bioorganic & Medicinal Chemistry, 1996, Moreau, Vincent et. al.
Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones
score: 1.1927086, European Journal of Medicinal Chemistry, 2009, Gligorijević, Nevenka et. al.
Synthesis of all possible regioisomers of scyllo-Inositol phosphate
score: 1.1925711, Bioorganic & Medicinal Chemistry, 1999, Chung, Sung-Kee et. al.
Synthesis of new carbon-11 labeled benzoxazole derivatives for PET imaging of 5-HT 3 receptor
score: 1.1925214, European Journal of Medicinal Chemistry, 2008, Gao, Mingzhang et. al.
Multi-target spectral moment: QSAR for antifungal drugs vs. different fungi species
score: 1.1924089, European Journal of Medicinal Chemistry, 2009, Prado-Prado, Francisco J. et. al.
Antiviral activity, pharmacokinetics, and safety of BMS-488043, a novel oral small-molecule HIV-1 attachment inhibitor, in HIV-1-infected subjects.
score: 1.1923881, Antimicrobial agents and chemotherapy, 2011, Hanna, George J et. al.
Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity.
score: 1.1923147, Antimicrobial agents and chemotherapy, 2011, Rajendran, Ranjith et. al.
Insight into siderophore-carrying peptide biosynthesis: enterobactin is a precursor for microcin E492 posttranslational modification.
score: 1.192249, Antimicrobial agents and chemotherapy, 2007, Vassiliadis, Gaëlle et. al.
Electrostatic interaction of π-Acidic amides with hydrogen-Bond acceptors
score: 1.1922291, Bioorganic & Medicinal Chemistry Letters, 2003, Li, Yi; Snyder, Lawrence B.; Langley, David R.
Novel trans-dichloridoplatinum(II) complexes with 3- and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity
score: 1.1922001, European Journal of Medicinal Chemistry, 2009, Rakić, Gordana M. et. al.
Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds
score: 1.192162, Bioorganic & Medicinal Chemistry, 2004, Otmar, Miroslav et. al.
Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis.
score: 1.1921135, Antimicrobial agents and chemotherapy, 2012, Pantel, Alix et. al.
Quantitative assessment of combination antimicrobial therapy against multidrug-resistant Acinetobacter baumannii.
score: 1.1920296, Antimicrobial agents and chemotherapy, 2008, Lim, Tze-Peng et. al.
Vinyl sulfonium as novel proteolytic enzyme inhibitor
score: 1.1918097, Bioorganic & Medicinal Chemistry Letters, 2001, Zhao, Gang; Zhou, Zhaohui S
Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins
score: 1.1917809, Bioorganic & Medicinal Chemistry Letters, 2004, Yang, Bin; Liu, Dongxiang; Huang, Ziwei
Enhancement of antimicrobial activity of neuropeptide Y by N-terminal truncation.
score: 1.1917456, Antimicrobial agents and chemotherapy, 1998, Shimizu, M; Shigeri, Y; Tatsu, Y; Yoshikawa, S; Yumoto, N
Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.
score: 1.1916705, Antimicrobial agents and chemotherapy, 2001, Gubareva, L V; Webster, R G; Hayden, F G
Screen for inducers of autolysis in Bacillus subtilis.
score: 1.1915041, Antimicrobial agents and chemotherapy, 2010, Falk, Shaun P; Noah, James W; Weisblum, Bernard
Adjuvant properties of a simplified C 32 monomycolyl glycerol analogue
score: 1.1914392, Bioorganic & Medicinal Chemistry Letters, 2009, Bhowruth, Veemal et. al.
Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii.
score: 1.1914362, Antimicrobial agents and chemotherapy, 2012, Hu, Hongyan et. al.
Lycopladines B–D and lyconadin B, new alkaloids from Lycopodium complanatum
score: 1.1914323, Bioorganic & Medicinal Chemistry, 2006, Ishiuchi, Kan’ichiro et. al.
An epoxidation mechanism of carbamazepine by CYP3A4
score: 1.1913828, Bioorganic & Medicinal Chemistry, 2008, Hata, Masayuki et. al.
Structure of C-terminal fragment of merozoite surface protein-1 from Plasmodium vivax determined by homology modeling and molecular dynamics refinement
score: 1.1913205, Bioorganic & Medicinal Chemistry, 2006, Serrano, María Luisa; Pérez, Hilda A.; Medina, J.D.
Antimicrobial properties of a chitosan dextran-based hydrogel for surgical use.
score: 1.191271, Antimicrobial agents and chemotherapy, 2012, Aziz, Manal A et. al.
Synthesis, structural characterization and in vitro antitumor activity of 4-dimethylaminopyridinium (6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)methanides
score: 1.1911471, European Journal of Medicinal Chemistry, 2003, Brzozowski, Zdzislaw; Sączewski, Franciszek; Gdaniec, Maria
Effects of chemical modification of sphingomyelin ammonium group on formation of liquid-ordered phase
score: 1.1911361, Bioorganic & Medicinal Chemistry, 2012, Goretta, Sarah A. et. al.
Effects of chemical modification of sphingomyelin ammonium group on formation of liquid-ordered phase
score: 1.1911361, Bioorganic & Medicinal Chemistry, 2012, Goretta, Sarah A. et. al.
Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29
score: 1.1910726, Bioorganic & Medicinal Chemistry, 2006, Styers, Thomas J. et. al.
Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase
score: 1.1910352, Bioorganic & Medicinal Chemistry Letters, 2009, Chai, Sergio C.; Ye, Qi-Zhuang
Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial.
score: 1.1910232, Antimicrobial agents and chemotherapy, 1998, Brueckner, R P et. al.
Inhibition of human coronavirus NL63 infection at early stages of the replication cycle.
score: 1.1910225, Antimicrobial agents and chemotherapy, 2006, Pyrc, Krzysztof et. al.
walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.
score: 1.1910117, Antimicrobial agents and chemotherapy, 2011, Shoji, Mitsutaka et. al.
Alumina-supported synthesis of antibacterial quinolines using microwaves
score: 1.1908944, Bioorganic & Medicinal Chemistry, 2000, Kidwai, M. et. al.
Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide
score: 1.1908821, Bioorganic & Medicinal Chemistry Letters, 2010, Di Fiore, Anna et. al.
Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain.
score: 1.1907847, Antimicrobial agents and chemotherapy, 2001, Oliver, A et. al.
Synthesis of prenylated benzaldehydes and their use in the synthesis of analogues of licochalcone A
score: 1.1907292, European Journal of Medicinal Chemistry, 2004, Kromann, Hasse et. al.
Short-Term Monotherapy with IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor, in Patients with Chronic Hepatitis C Virus Infection.
score: 1.190726, Antimicrobial agents and chemotherapy, 2012, Lalezari, Jacob et. al.
Kinetics and docking studies of two potential new inhibitors of the nucleoside hydrolase from Leishmania donovani
score: 1.190713, European Journal of Medicinal Chemistry, 2012, Rennó, Magdalena Nascimento et. al.
Kinetics and docking studies of two potential new inhibitors of the nucleoside hydrolase from Leishmania donovani
score: 1.190713, European Journal of Medicinal Chemistry, 2012, Rennó, Magdalena Nascimento et. al.
Classification of drugs according to their milk/plasma concentration ratio
score: 1.1907044, European Journal of Medicinal Chemistry, 2010, Fatemi, Mohammad H.; Ghorbanzad’e, Mehdi
Inhibition of inosine monophosphate dehydrogenase (IMPDH) by the antiviral compound, 2-vinylinosine monophosphate
score: 1.1906439, Bioorganic & Medicinal Chemistry, 2002, Pal, Suresh; Bera, Bindu; Nair, Vasu
Synthesis of novel pyrrolyl-indomethacin derivatives
score: 1.1906392, European Journal of Medicinal Chemistry, 2012, Serra Moreno, Judith et. al.
Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete [1] 1 Dedicated to the memory of Professor Sir Derek H. R. Barton (1918–1998), a great chemist and friend. 1
score: 1.1906353, Bioorganic & Medicinal Chemistry, 1999, Pettit, George R. et. al.
Novel Pyrrolo[3,2- f]quinolines: Synthesis and Antiproliferative Activity
score: 1.1905496, Bioorganic & Medicinal Chemistry, 2001, Ferlin, M.G; Gatto, B; Chiarelotto, G; Palumbo, M
Protein–DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acid
score: 1.1905495, Bioorganic & Medicinal Chemistry Letters, 2009, Lee, Hyun Soo; Dimla, Romerson D.; Schultz, Peter G.
Retraction notice to “A computational docking study for prediction of binding mode of diospyrin and derivatives: Inhibitors of human and leishmanial DNA topoisomerase-I” [Bioorg. Med. Chem. Lett. 17 (2007) 4604–4612]
score: 1.190537, Bioorganic & Medicinal Chemistry Letters, 2007, Chhabra, Sandeep; Sharma, Pooja; Ghoshal, Nanda
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
score: 1.1905118, Antimicrobial agents and chemotherapy, 2004, Dubois, Véronique et. al.
Molecular alignment using multipole moments
score: 1.1904787, Bioorganic & Medicinal Chemistry Letters, 2010, Moretti, Loris; Graham Richards, W.
A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: A universal and dipeptide mimetic template
score: 1.1904641, Bioorganic & Medicinal Chemistry, 1996, Cheng, Soan et. al.
In vitro activity of gemifloxacin (SB 265805) against anaerobes.
score: 1.1904018, Antimicrobial agents and chemotherapy, 1999, Goldstein, E J et. al.
Pharmacokinetics of an everninomicin (SCH 27899) in mice, rats, rabbits, and cynomolgus monkeys following intravenous administration.
score: 1.1902719, Antimicrobial agents and chemotherapy, 2000, Lin, C; Gupta, S; Loebenberg, D; Cayen, M N
RAR–RXR Selectivity and Biological Activity of New Retinoic Acid Analogues with Heterocyclic or Polycyclic Aromatic Systems
score: 1.1902544, Bioorganic & Medicinal Chemistry, 2002, Ivanova, D. et. al.
Population pharmacokinetics of cefepime in the neonate.
score: 1.1902347, Antimicrobial agents and chemotherapy, 2005, Capparelli, Edmund et. al.
The Synthesis of 4-Arylsulfanyl-substituted Kainoid Analogues from trans-4-Hydroxy- l-proline
score: 1.1901546, Bioorganic & Medicinal Chemistry Letters, 2000, Baldwin, Jack E; Pritchard, Gareth J; Williamson, Douglas S
Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis.
score: 1.1901245, Antimicrobial agents and chemotherapy, 2005, Ibrahim, Ashraf S et. al.
Structure-function studies of Ser-289 in the class C beta-lactamase from Enterobacter cloacae P99.
score: 1.1900993, Antimicrobial agents and chemotherapy, 1999, Trépanier, S et. al.
An investigation of antibody acyl hydrolysis catalysis using a large set of related haptens
score: 1.1900673, Bioorganic & Medicinal Chemistry, 2000, Odenbaugh, Amy L.; Helms, Eric D.; Iverson, Brent L.
In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis.
score: 1.1900514, Antimicrobial agents and chemotherapy, 2012, Lechartier, Benoit; Hartkoorn, Ruben C; Cole, Stewart T
Nitrofurantoin is active against vancomycin-resistant enterococci.
score: 1.190051, Antimicrobial agents and chemotherapy, 2001, Zhanel, G G; Hoban, D J; Karlowsky, J A
Synthesis and duplex DNA recognition studies of oligonucleotides containing a ureido isoindolin-1-one homo- N-nucleoside. A comparison of host–guest and DNA recognition studies
score: 1.189987, Bioorganic & Medicinal Chemistry, 2004, Mertz, Eric; Mattei, Sebastiano; Zimmerman, Steven C
Comparative activities of clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, ofloxacin, sparfloxacin, and trovafloxacin and nonquinolones linozelid, quinupristin-dalfopristin, gentamicin, and vancomycin against clinical isolates of ciprofloxacin-resistant and -susceptible Staphylococcus aureus strains.
score: 1.1899797, Antimicrobial agents and chemotherapy, 1999, Jones, M E et. al.
Identification of potent bactericidal compounds produced by escapin, an L-amino acid oxidase in the ink of the sea hare Aplysia californica.
score: 1.1898661, Antimicrobial agents and chemotherapy, 2008, Ko, Ko-Chun; Wang, Binghe; Tai, Phang C; Derby, Charles D
In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi.
score: 1.1898614, Antimicrobial agents and chemotherapy, 2005, Cuenca-Estrella, Manuel et. al.
Quantitative structure–activity relationship study on some nonpeptidal cholecystokinin antagonists
score: 1.1898291, Bioorganic & Medicinal Chemistry, 1999, Sinha, Jyoti; Kurup, Alka; Paleti, Anitha; Gupta, S.P.
High incidence of cefoxitin and clindamycin resistance among anaerobes in Taiwan.
score: 1.1897904, Antimicrobial agents and chemotherapy, 2002, Teng, Lee-Jene et. al.
In vitro activity of doripenem against Burkholderia cepacia complex isolates from non-cystic fibrosis patients.
score: 1.1897018, Antimicrobial agents and chemotherapy, 2011, Singhal, Lipika; Gautam, Vikas; Kaur, Mandeep; Ray, Pallab
Synthesis and evaluation of novel dipeptide-bound 1,2,4-Thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase
score: 1.1895502, Bioorganic & Medicinal Chemistry, 2001, Marrano, Claudio et. al.
1-Aza-sugars from d-glucose. Preparation of 1-deoxy-5-dehydroxymethyl-nojirimycin, its analogues and evaluation of glycosidase inhibitory activity
score: 1.1894717, Bioorganic & Medicinal Chemistry, 2002, Patil, Nitin T et. al.
Pharmacodynamic modeling of in vitro activity of marbofloxacin against Escherichia coli strains.
score: 1.1893829, Antimicrobial agents and chemotherapy, 2011, Andraud, M; Chauvin, C; Sanders, P; Laurentie, M
Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
score: 1.1892829, Bioorganic & Medicinal Chemistry Letters, 2005, Olson, Steven et. al.
In vitro activity and in vivo efficacy of clavulanic acid against Acinetobacter baumannii.
score: 1.1892598, Antimicrobial agents and chemotherapy, 2009, Beceiro, Alejandro et. al.
5-HT 6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
score: 1.1892414, European Journal of Medicinal Chemistry, 2001, Bös, Michael et. al.
Anticancer siRNA delivery by new anticancer molecule: A novel combination strategy for cancer cell killing
score: 1.1892024, European Journal of Medicinal Chemistry, 2012, Muktapuram, Prathap Reddy et. al.
Anticancer siRNA delivery by new anticancer molecule: A novel combination strategy for cancer cell killing
score: 1.1892024, European Journal of Medicinal Chemistry, 2012, Muktapuram, Prathap Reddy et. al.
In vitro combination of amdoxovir and the inosine monophosphate dehydrogenase inhibitors mycophenolic acid and ribavirin demonstrates potent activity against wild-type and drug-resistant variants of human immunodeficiency virus type 1.
score: 1.1890909, Antimicrobial agents and chemotherapy, 2004, Borroto-Esoda, Katyna et. al.
A new sulfonamide resistance gene (sul3) in Escherichia coli is widespread in the pig population of Switzerland.
score: 1.1890811, Antimicrobial agents and chemotherapy, 2003, Perreten, Vincent; Boerlin, Patrick
Comparative in vivo efficacies of epithelial lining fluid exposures of tedizolid, linezolid, and vancomycin for methicillin-resistant Staphylococcus aureus in a mouse pneumonia model.
score: 1.1889814, Antimicrobial agents and chemotherapy, 2012, Tessier, Pamela R et. al.
Genistein derivatives as selective estrogen receptor modulators: Sonochemical synthesis and in vivo anti-osteoporotic action
score: 1.1888792, Bioorganic & Medicinal Chemistry, 2005, Wang, Shi F. et. al.
Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids
score: 1.1888293, Bioorganic & Medicinal Chemistry, 1996, Atuegbu, Andy et. al.
Synthesis and structure–activity relationships of a new model of arylpiperazines. Part 7: Study of the influence of lipophilic factors at the terminal amide fragment on 5-HT 1A affinity/selectivity
score: 1.1886822, Bioorganic & Medicinal Chemistry, 2004, López-Rodrı́guez, Marı́a L et. al.
Facile preparation of deuterium-labeled N-acylhomoserine lactones as internal standards for isotope dilution mass spectrometry
score: 1.1886636, Bioorganic & Medicinal Chemistry, 2010, Kai, Kenji; Tani, Ayaka; Hayashi, Hideo
Polymer-Bound 1-Aryl-3-alkyltriazenes as Modular Ligands for Catalysis. Part 2: Screening Immobilized Metal Complexes for Catalytic Activity
score: 1.1885487, Bioorganic & Medicinal Chemistry Letters, 2002, Bräse, Stefan et. al.
Synthesis of novel octa-cationic and non-ionic 1,2-ethanediamine substituted zinc (Ⅱ) phthalocyanines and their in vitro anti-cancer activity comparison
score: 1.1885451, European Journal of Medicinal Chemistry, 2012, Wang, Ao et. al.
Stereo-random synthesis of highly functionalized proline analogues by azomethine cycloaddition
score: 1.1884882, Bioorganic & Medicinal Chemistry Letters, 2000, Henkel, Bernd; Stenzel, Wolfgang; Schotten, Theo
Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells
score: 1.1884881, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Ji Hwan et. al.
Efficacies of zinc-finger-active drugs against Giardia lamblia.
score: 1.1883666, Antimicrobial agents and chemotherapy, 1998, Nash, T; Rice, W G
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors
score: 1.1883414, European Journal of Medicinal Chemistry, 2012, Liu, Jingbao et. al.
Efficacy of ceftriaxone and gentamicin given once a day by using human-like pharmacokinetics in treatment of experimental staphylococcal endocarditis.
score: 1.1882751, Antimicrobial agents and chemotherapy, 2002, Gavaldà, Joan et. al.
Alanyl-PNA homoduplex: A-T pairing with the N7-regioisomer of adenine
score: 1.1882455, Bioorganic & Medicinal Chemistry Letters, 1998, Diederichsen, Ulf
Novel antibiotic susceptibility tests by the ATP-bioluminescence method using filamentous cell treatment.
score: 1.188188, Antimicrobial agents and chemotherapy, 1998, Hattori, N; Nakajima, M O; O'Hara, K; Sawai, T
Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents
score: 1.1881879, European Journal of Medicinal Chemistry, 2012, Mor, Satbir; Pahal, Preeti; Narasimhan, Balasubramanian
Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents
score: 1.1881879, European Journal of Medicinal Chemistry, 2012, Mor, Satbir; Pahal, Preeti; Narasimhan, Balasubramanian
( R)-Goniothalamin: total syntheses and cytotoxic activity against cancer cell lines
score: 1.1881549, Bioorganic & Medicinal Chemistry, 2005, de Fátima, Ângelo et. al.
Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.
score: 1.1881215, Antimicrobial agents and chemotherapy, 2004, Aubry, Alexandra et. al.
Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers.
score: 1.1880788, Antimicrobial agents and chemotherapy, 2012, Chinsangaram, Jarasvech et. al.
Targeting antibacterial agents by using drug-carrying filamentous bacteriophages.
score: 1.1879823, Antimicrobial agents and chemotherapy, 2006, Yacoby, Iftach et. al.
Synthesis and stability of two indomethacin prodrugs
score: 1.187973, Bioorganic & Medicinal Chemistry Letters, 2006, Chandrasekaran, Shyamala et. al.
Lambertellol C, a labile and novel biosynthetic congener of lambertellols A and B
score: 1.1879586, Bioorganic & Medicinal Chemistry Letters, 2005, Murakami, Takanori et. al.
Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria.
score: 1.1879389, Antimicrobial agents and chemotherapy, 2000, Friedrich, C L; Moyles, D; Beveridge, T J; Hancock, R E
Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.
score: 1.1878828, Antimicrobial agents and chemotherapy, 2002, Bugnon, Denis et. al.
2′-Deoxy-1-methylpseudocytidine, a stable analog of 2′-deoxy-5-methyl isocytidine
score: 1.1878509, Bioorganic & Medicinal Chemistry, 2009, Kim, Hyo-Joong; Leal, Nicole A.; Benner, Steven A.
Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii.
score: 1.187611, Antimicrobial agents and chemotherapy, 2005, Héritier, Claire et. al.
Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling
score: 1.1876005, Bioorganic & Medicinal Chemistry, 2005, Gu, Ling et. al.
Synthesis and evaluation of a new inhibitor of phosphoglucose isomerases: the enediolate analogue 5-phospho-D-arabinohydroxamate
score: 1.1875016, Bioorganic & Medicinal Chemistry Letters, 1998, Hardré, Renaud et. al.
Scanning the prime-Site substrate specificity of proteolytic enzymes: A novel assay based on ligand-Enhanced lanthanide ion fluorescence
score: 1.1874922, Bioorganic & Medicinal Chemistry Letters, 2002, Barrios, Amy M.; Craik, Charles S.
In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins.
score: 1.1874505, Antimicrobial agents and chemotherapy, 2000, Benoit-Vical, F; Robert, A; Meunier, B
QSAR study of 1,4-dihydropyridine calcium channel antagonists based on gene expression programming
score: 1.1872834, Bioorganic & Medicinal Chemistry, 2006, Si, Hong Zong et. al.
Antibody mapping of the linear epitopes of CMY-2 and SHV-1 beta-lactamases.
score: 1.1872198, Antimicrobial agents and chemotherapy, 2004, Hujer, Andrea M; Bethel, Christopher R; Bonomo, Robert A
Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids. I. Synthesis and biological evaluation of lipophilic conjugates of tranylcypromine
score: 1.1871655, European Journal of Medicinal Chemistry, 2005, Pignatello, Rosario et. al.
Efficacy of garenoxacin in treatment of experimental endocarditis due to Staphylococcus aureus or viridans group streptococci.
score: 1.1871212, Antimicrobial agents and chemotherapy, 2004, Entenza, José M et. al.
Topological models for prediction of anti-inflammatory activity of N-arylanthranilic acids
score: 1.1870856, Bioorganic & Medicinal Chemistry, 2004, Bajaj, Sanjay; Sambi, S.S.; Madan, A.K.
Synthesis of a new series of 4-chloro-2-mercapto-5-methylbenzenesulfonamide derivatives with potential antitumor activity
score: 1.1870575, European Journal of Medicinal Chemistry, 2004, Sławiński, Jarosław
Abbott Physicochemical Tiering (APT)—A unified approach to HTS triage
score: 1.1869001, Bioorganic & Medicinal Chemistry, 2012, Cox, Philip B.; Gregg, Robert; Vasudevan, Anil
Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates
score: 1.1868973, European Journal of Medicinal Chemistry, 2005, Romagnoli, Romeo et. al.
The F423Y mutation in the pfmdr2 gene and mutations N51I, C59R, and S108N in the pfdhfr gene are independently associated with pyrimethamine resistance in Plasmodium falciparum isolates.
score: 1.1867904, Antimicrobial agents and chemotherapy, 2012, Briolant, Sébastien et. al.
Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies.
score: 1.1867852, Antimicrobial agents and chemotherapy, 2011, Mariner, Katherine R et. al.
A new acivicin prodrug designed for tumor-Targeted delivery
score: 1.1867531, Bioorganic & Medicinal Chemistry, 2001, Antczak, Christophe et. al.
Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors
score: 1.1867378, European Journal of Medicinal Chemistry, 2003, Gfesser, Gregory A et. al.
Novel ferrocenic artemisinin derivatives: synthesis, in vitro antimalarial activity and affinity of binding with ferroprotoporphyrin IX
score: 1.1867119, Bioorganic & Medicinal Chemistry, 2000, Delhaes, L et. al.
Synthesis and biological evaluation of N-{4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl}- l-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway
score: 1.1867014, Bioorganic & Medicinal Chemistry, 2005, Cheng, Heng et. al.
Synthesis, structural characterization and In vitro antitumor activity of novel 6-Chloro-1,1-dioxo-1,4,2-benzodithiazie derivatives
score: 1.1866392, Bioorganic & Medicinal Chemistry, 2003, Brzozowski, Zdzislaw; Sa̧czewski, Franciszek; Gdaniec, Maria
Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework
score: 1.1865513, European Journal of Medicinal Chemistry, 2005, Messaoudi, Samir et. al.
Population pharmacokinetics of intramuscular quinine in children with severe malaria.
score: 1.1865422, Antimicrobial agents and chemotherapy, 2001, Krishna, S et. al.
Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12
score: 1.1865238, Bioorganic & Medicinal Chemistry, 2006, Holas, Tomáš et. al.
Production and characterization of stable amphotericin-resistant amastigotes and promastigotes of Leishmania mexicana.
score: 1.1864324, Antimicrobial agents and chemotherapy, 2005, Al-Mohammed, Hamdan I; Chance, Michael L; Bates, Paul A
In vitro activity of moxifloxacin against 923 anaerobes isolated from human intra-abdominal infections.
score: 1.186429, Antimicrobial agents and chemotherapy, 2006, Goldstein, Ellie J C et. al.
Inhibition of HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates zinc ions from retroviral nucleocapsid zinc fingers.
score: 1.1862681, Antimicrobial agents and chemotherapy, 2010, Pannecouque, Christophe et. al.
Anti-Candida activity of a new platinum derivative.
score: 1.1862252, Antimicrobial agents and chemotherapy, 2000, Watanabe, T et. al.
MC21-A, a bactericidal antibiotic produced by a new marine bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30(T), against methicillin-resistant Staphylococcus aureus.
score: 1.1861908, Antimicrobial agents and chemotherapy, 2003, Isnansetyo, Alim; Kamei, Yuto
Quantitative structure–Activity relationship studies on 5-phenyl-3-ureido-1,5-benzodiazepine as cholecystokinin-A receptor antagonists
score: 1.1860951, Bioorganic & Medicinal Chemistry, 2002, Agrawal, Vijay K.; Sharma, Ruchi; Khadikar, Padmakar V.
Synthesis, characterization and biological activity of Pt(II) and Pt(IV) complexes with 5-methyl-5(4-pyridyl)-2,4-imidazolidenedione
score: 1.1860192, European Journal of Medicinal Chemistry, 2008, Bakalova, Adriana et. al.
Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA.
score: 1.1859982, Antimicrobial agents and chemotherapy, 2001, Montero, C; Mateu, G; Rodriguez, R; Takiff, H
Oxathiolene oxide synthesis via chelation-controlled addition of organometallic reagents to alkynols followed by addition of sulfur electrophiles and evaluation of oxathiolene oxides as anticarcinogenic enzyme inducers
score: 1.1859536, Bioorganic & Medicinal Chemistry, 2005, Franks, Marion A. et. al.
Structure-Based mutagenesis approaches toward expanding the substrate specificity of d-2-Deoxyribose-5-phosphate aldolase
score: 1.1859469, Bioorganic & Medicinal Chemistry, 2003, DeSantis, Grace et. al.
Quaternized chitosan inhibits icaA transcription and biofilm formation by Staphylococcus on a titanium surface.
score: 1.1859189, Antimicrobial agents and chemotherapy, 2011, Peng, Zhao-Xiang et. al.
11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [ 11C]zofenoprilat
score: 1.1859141, Bioorganic & Medicinal Chemistry, 2004, Matarrese, Mario et. al.
Synthesis and Biological Activity of Novel Neuroprotective Diketopiperazines
score: 1.1857967, Bioorganic & Medicinal Chemistry, 2002, Prakash, K.R.C et. al.
Polymerase-directed synthesis of C5-ethynyl locked nucleic acids
score: 1.1857176, Bioorganic & Medicinal Chemistry Letters, 2010, Veedu, Rakesh N. et. al.
Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin.
score: 1.1856573, Antimicrobial agents and chemotherapy, 2006, Chamilos, Georgios et. al.
Antinociceptive activity of new imidazolidine carbonyl derivatives.
score: 1.1855574, European Journal of Medicinal Chemistry, 2005, Sztanke, Krzysztof et. al.
Photomodulation of PS-modified oligonucleotides containing azobenzene substituent at pre-selected positions in phosphate backbone
score: 1.1855447, Bioorganic & Medicinal Chemistry, 2007, Patnaik, Satyakam et. al.
Knowledgebase for addiction-related genes: Is it possible an extrapolation to rational multi-target drug design?
score: 1.1855445, Bioorganic & Medicinal Chemistry, 2008, Michel Espinoza-Fonseca, L.
The effects of aminoguanidine on retinopathy in STZ-induced diabetic rats
score: 1.1855222, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Dawei; Fan, Ying; Xu, Xun
The effects of aminoguanidine on retinopathy in STZ-induced diabetic rats
score: 1.1855222, Bioorganic & Medicinal Chemistry Letters, 2012, Luo, Dawei; Fan, Ying; Xu, Xun
Image contrast agents activated by prostate specific antigen (PSA)
score: 1.185499, Bioorganic & Medicinal Chemistry Letters, 2004, Jones, Graham B. et. al.
Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model.
score: 1.1854944, Antimicrobial agents and chemotherapy, 2008, Lounis, Nacer et. al.
T-2307 causes collapse of mitochondrial membrane potential in yeast.
score: 1.1853227, Antimicrobial agents and chemotherapy, 2012, Shibata, Tatsuya et. al.
An efficient one-pot synthesis and photoinduced DNA cleavage studies of 2-chloro-3-(5-aryl-4,5-dihydroisoxazol-3-yl)quinolines
score: 1.1852844, Bioorganic & Medicinal Chemistry Letters, 2012, Bindu, P.J.; Mahadevan, K.M.; Ravikumar Naik, T.R.
Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood–brain barrier
score: 1.1852754, Bioorganic & Medicinal Chemistry Letters, 2006, Tilloy, Sébastien et. al.
Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.
score: 1.1852325, Antimicrobial agents and chemotherapy, 2004, Niimi, K et. al.
Using interrupted time series analysis to assess associations of fluoroquinolone formulary changes with susceptibility of gram-negative pathogens and isolation rates of methicillin-resistant Staphylococcus aureus.
score: 1.1851534, Antimicrobial agents and chemotherapy, 2006, Bosso, John A; Mauldin, Patrick D
Pyrene–perylene as a FRET pair coupled to the N2′-functionality of 2′-amino-LNA
score: 1.1850636, Bioorganic & Medicinal Chemistry, 2008, Lindegaard, Dorthe et. al.
Synthesis, anticonvulsant activity and 5-HT 1A, 5-HT 2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione
score: 1.1850191, European Journal of Medicinal Chemistry, 2006, Obniska, J.; Kołaczkowski, M.; Bojarski, A.J.; Duszyńska, B.
Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.
score: 1.1849773, Antimicrobial agents and chemotherapy, 2010, Min-Oo, Gundula et. al.
Synthesis, physico-chemical properties and penetration activity of alkyl-6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxopyrrolidin-1-yl)hexanoates as potential transdermal penetration enhancers
score: 1.1849533, Bioorganic & Medicinal Chemistry, 2010, Brychtova, Katerina et. al.
Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives
score: 1.1849166, European Journal of Medicinal Chemistry, 2012, Garudachari, B. et. al.
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense
score: 1.1848917, Bioorganic & Medicinal Chemistry Letters, 2012, Vullo, Daniela et. al.
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense
score: 1.1848917, Bioorganic & Medicinal Chemistry Letters, 2012, Vullo, Daniela et. al.
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense
score: 1.1848917, Bioorganic & Medicinal Chemistry Letters, 2012, Vullo, Daniela et. al.
Antimicrobial activity of quinupristin-dalfopristin combined with other antibiotics against vancomycin-resistant enterococci.
score: 1.1848143, Antimicrobial agents and chemotherapy, 2002, Eliopoulos, G M; Wennersten, C B
Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa.
score: 1.1848125, Antimicrobial agents and chemotherapy, 2005, Poirel, Laurent et. al.
Complexation of single strand telomere and telomerase RNA template polyanions by deoxyribonucleic guanidine (DNG) polycations: Plausible anticancer agents
score: 1.1847668, Bioorganic & Medicinal Chemistry Letters, 2008, Zhang, Xiaohua; Bruice, Thomas C.
In vitro activity of doripenem against Pseudomonas aeruginosa and Burkholderia cepacia isolates from both cystic fibrosis and non-cystic fibrosis patients.
score: 1.1845597, Antimicrobial agents and chemotherapy, 2006, Traczewski, M M; Brown, S D
Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N→N proton transfer
score: 1.1845006, Bioorganic & Medicinal Chemistry Letters, 2009, Donahue, Matthew G.; Hong, Ki Bum; Johnston, Jeffrey N.
A cationic chalcogenoxanthylium photosensitizer effective in vitro in chemosensitive and multidrug-resistant cells
score: 1.1844909, Bioorganic & Medicinal Chemistry, 2006, Holt, Jason J. et. al.
Chromosome-encoded AmpC and CTX-M extended-spectrum β-lactamases in clinical isolates of Proteus mirabilis from Korea.
score: 1.1844322, Antimicrobial agents and chemotherapy, 2011, Song, Wonkeun et. al.
In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).
score: 1.1843453, Antimicrobial agents and chemotherapy, 1999, Petersen, P J et. al.
Design, synthesis, and biological evaluation of alcyopterosin A and illudalane derivatives as anticancer agents
score: 1.1842954, Bioorganic & Medicinal Chemistry, 2006, Finkielsztein, Liliana M. et. al.
Peptide nucleic acid fluorescent in situ hybridization for hospital-acquired enterococcal bacteremia: delivering earlier effective antimicrobial therapy.
score: 1.184283, Antimicrobial agents and chemotherapy, 2008, Forrest, Graeme N et. al.
Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation.
score: 1.1841565, Antimicrobial agents and chemotherapy, 2001, Kanamoto, T et. al.
Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects.
score: 1.1841554, Antimicrobial agents and chemotherapy, 2008, Van Rompay, Koen K A et. al.
Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence
score: 1.1841348, Bioorganic & Medicinal Chemistry Letters, 2004, Sato, Megumi; Moriguchi, Tomohisa; Shinozuka, Kazuo
Phenotypic expression of oxacillin resistance in Staphylococcus epidermidis: roles of mecA transcriptional regulation and resistant-subpopulation selection.
score: 1.1840457, Antimicrobial agents and chemotherapy, 2000, Dickinson, T M; Archer, G L
A stereoselective α-fucosylation reaction using 1-hydroxy 2,3,4- tri-O- benzyl- l-fucose donor for the practical synthesis of selectin blocker
score: 1.1840122, Bioorganic & Medicinal Chemistry Letters, 1998, Kiyoi, Takao; Kondo, Hirosato
Synthesis and antisense properties of oligodeoxyribonucleotides containing C5-substituted arabinofuranosyluracil
score: 1.1838425, Bioorganic & Medicinal Chemistry Letters, 2004, Ozaki, Hiroaki et. al.
Analogues of Human Parathyroid Hormone (1–31)NH 2: Further Evaluation of the Effect of Conformational Constraint on Biological Activity
score: 1.1838416, Bioorganic & Medicinal Chemistry, 2002, Condon, Stephen M et. al.
Electrophilic α-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones
score: 1.183809, Bioorganic & Medicinal Chemistry Letters, 2008, Falck, J.R. et. al.
An improved procedure for the synthesis of branched polyethylene glycols (PEGs) with the reporter dipeptide met-βala for protein conjugation
score: 1.1836783, Bioorganic & Medicinal Chemistry Letters, 2002, Guiotto, Andrea et. al.
Construction of protein-modified TiO 2 nanoparticles for use with ultrasound irradiation in a novel cell injuring method
score: 1.1834405, Bioorganic & Medicinal Chemistry Letters, 2010, Ogino, Chiaki et. al.
Effect of incorporation of alkyl linkers into siRNAs on RNA interference
score: 1.1834357, Bioorganic & Medicinal Chemistry Letters, 2009, Ueno, Yoshihito et. al.
Comparison of CO2 generation (BACTEC) and viable-count methods to determine the postantibiotic effect of antimycobacterial agents against Mycobacterium avium complex.
score: 1.1833608, Antimicrobial agents and chemotherapy, 1998, Zhanel, G G et. al.
Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue
score: 1.1833535, Bioorganic & Medicinal Chemistry Letters, 2006, Kojima, Naoshi et. al.
Efficient chemoenzymatic synthesis of ( S)- and ( R)-5-(1-Aminoethyl)-2-(cyclohexylmethoxy)benzamide: key intermediate for Src-SH2 inhibitor
score: 1.1833187, Bioorganic & Medicinal Chemistry Letters, 2002, Kamal, Ahmed; Sandbhor, Mahendra
Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer
score: 1.1832298, Bioorganic & Medicinal Chemistry Letters, 2012, Mock, Jason N. et. al.
Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer
score: 1.1832298, Bioorganic & Medicinal Chemistry Letters, 2012, Mock, Jason N. et. al.
Conformational search for the N 6-substituted adenosine analogues and related adenosine A 1 receptor antagonists
score: 1.1832233, Bioorganic & Medicinal Chemistry, 1996, Dooley, Michael J.; Kono, Motomichi; Suzuki, Fumio
Voriconazole-induced inhibition of the fungicidal activity of amphotericin B in Candida strains with reduced susceptibility to voriconazole: an effect not predicted by the MIC value alone.
score: 1.1832105, Antimicrobial agents and chemotherapy, 2011, Lignell, Anders et. al.
Venezuelines A–G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77
score: 1.1831714, Bioorganic & Medicinal Chemistry Letters, 2013, Ren, Jinwei et. al.
Flavin-sensitized photoreduction of thymidine glycol
score: 1.183055, Bioorganic & Medicinal Chemistry Letters, 2007, Ito, Takeo et. al.
In vitro activity of ceftaroline against clinical isolates of Streptococcus pneumoniae recovered in 43 U.S. medical centers during 2010-2011.
score: 1.182999, Antimicrobial agents and chemotherapy, 2012, Doern, Gary V et. al.
GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate
score: 1.1829978, European Journal of Medicinal Chemistry, 2012, Leurs, Ulrike et. al.
Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.
score: 1.1829109, Antimicrobial agents and chemotherapy, 2003, Lasala, Fátima et. al.
Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores.
score: 1.1828768, Antimicrobial agents and chemotherapy, 2004, Fluckinger, Maria et. al.
Effects of B group vitamins on reactions of various α-hydroxyl-containing organic radicals
score: 1.1827258, Bioorganic & Medicinal Chemistry Letters, 2005, Lagutin, P. Yu.; Shadyro, O.I.
Small molecule modulators of aggregation in synthetic melanin polymerizations
score: 1.1826925, Bioorganic & Medicinal Chemistry Letters, 2012, Belitsky, Jason M. et. al.
Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth
score: 1.1826792, European Journal of Medicinal Chemistry, 2010, Valle-Argos, Beatriz et. al.
A rational strategy for enhancing the affinity of vancomycin towards depsipeptide ligands
score: 1.1826754, Bioorganic & Medicinal Chemistry, 1998, Axelsen, Paul H.; Li, Daohui
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.
score: 1.1826533, Antimicrobial agents and chemotherapy, 1998, Naesens, L et. al.
In vitro pharmacodynamic studies of L-749,345 in comparison with imipenem and ceftriaxone against gram-positive and gram-negative bacteria.
score: 1.1826344, Antimicrobial agents and chemotherapy, 1998, Odenholt, I; Löwdin, E; Cars, O
Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging
score: 1.1824334, Bioorganic & Medicinal Chemistry Letters, 2007, Zhang, Yi et. al.
Pyrinadines B–G, new bis-pyridine alkaloids with an azoxy moiety from sponge Cribrochalina sp.
score: 1.1824128, Bioorganic & Medicinal Chemistry, 2006, Kariya, Yuuko et. al.
Novel peptidomimics as angiotensin-Converting enzyme inhibitors: A combinatorial approach
score: 1.182392, Bioorganic & Medicinal Chemistry, 2002, Bala, Manju; Qadar Pasha, M.A; Bhardwaj, D.K; Pasha, Santosh
Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes
score: 1.1823607, Bioorganic & Medicinal Chemistry, 2006, Mishra, A.K. et. al.
Synthesis of conformationally restricted 2′,3′- exo-Methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template
score: 1.1823131, Bioorganic & Medicinal Chemistry, 2002, Bhushan, Rashmi Gupta; Vince, Robert
On the isomerisation of cefozopran in solution
score: 1.181994, European Journal of Medicinal Chemistry, 2010, Liu, Shu-Yu; Zhang, Dou-Sheng; Hu, Chang-Qin
Synthesis, anti-mycobacterial, anti-trichomonas and anti-candida in vitro activities of 2-substituted-6,7-difluoro-3-methylquinoxaline 1,4-dioxides
score: 1.1819442, European Journal of Medicinal Chemistry, 2004, Carta, Antonio et. al.
Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors
score: 1.1818598, Bioorganic & Medicinal Chemistry, 1997, Arslan, Oktay; Irfan Küfrevioğlu, Ö.; Nalbantoğlu, Barbaros
T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells
score: 1.1818543, Bioorganic & Medicinal Chemistry Letters, 2012, Rim, Hong-Kun et. al.
T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells
score: 1.1818543, Bioorganic & Medicinal Chemistry Letters, 2012, Rim, Hong-Kun et. al.
T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells
score: 1.1818543, Bioorganic & Medicinal Chemistry Letters, 2012, Rim, Hong-Kun et. al.
T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells
score: 1.1818543, Bioorganic & Medicinal Chemistry Letters, 2012, Rim, Hong-Kun et. al.
Synthesis and evaluation of α,α-disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor design
score: 1.1818405, Bioorganic & Medicinal Chemistry, 2003, Lee, Hyun Soo; Kim, Dong H
Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction
score: 1.1818195, Bioorganic & Medicinal Chemistry, 2000, Tobe, Masanori et. al.
Specificity of neomycin analogues bound to the packaging region of human immunodeficiency virus type 1 RNA
score: 1.1817323, Bioorganic & Medicinal Chemistry, 2004, McPike, Mark P; Goodisman, Jerry; Dabrowiak, James C
Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin.
score: 1.181729, Antimicrobial agents and chemotherapy, 2008, Lodise, T P et. al.
In vitro activities of DX-619 and comparison quinolones against gram-positive cocci.
score: 1.1816903, Antimicrobial agents and chemotherapy, 2006, Wickman, Paul A et. al.
Analysis of structure–activity relationships with the N-(3-acyloxy-2-benzylpropyl)- N ′-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism
score: 1.1815998, Bioorganic & Medicinal Chemistry, 2004, Lee, Jeewoo et. al.
Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B.
score: 1.1815769, Antimicrobial agents and chemotherapy, 2001, Gottfredsson, M et. al.
Specific volume and compressibility of human serum albumin–polyanion complexes
score: 1.1814756, Bioorganic & Medicinal Chemistry Letters, 2006, Hianik, Tibor et. al.
Modulation of base selectivity for a base-discriminating fluorescent nucleobase by addition of mercury ion
score: 1.1814052, Bioorganic & Medicinal Chemistry Letters, 2005, Okamoto, Akimitsu; Ochi, Yuji; Saito, Isao
Antibacterial action of polyphosphate on Porphyromonas gingivalis.
score: 1.1811577, Antimicrobial agents and chemotherapy, 2011, Moon, Ji-Hoi; Park, Jae-Hong; Lee, Jin-Yong
Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT 1 receptors over melatonin MT 2 receptors
score: 1.1811375, European Journal of Medicinal Chemistry, 2004, Larraya, Carlos et. al.
Reducing mortality in Salmonella enterica serovar Typhimurium-infected mice with a tripeptidic serum fraction.
score: 1.1811059, Antimicrobial agents and chemotherapy, 2002, Parker, Todd A et. al.
Evolution of specific RNA motifs derived from pan-protein interacting precursors
score: 1.1810601, Bioorganic & Medicinal Chemistry Letters, 2010, Ahmed, Marie-Sophie L.; Mayer, Günter
Azithromycin inhibits expression of the GacA-dependent small RNAs RsmY and RsmZ in Pseudomonas aeruginosa.
score: 1.1810029, Antimicrobial agents and chemotherapy, 2011, Pérez-Martínez, Isabel; Haas, Dieter
Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines
score: 1.1810017, Bioorganic & Medicinal Chemistry Letters, 2012, Schulz, Riad et. al.
Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines
score: 1.1810017, Bioorganic & Medicinal Chemistry Letters, 2012, Schulz, Riad et. al.
Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential.
score: 1.1808841, Antimicrobial agents and chemotherapy, 2004, Mushtaq, Shazad; Ge, Yigong; Livermore, David M
Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides
score: 1.1808459, Bioorganic & Medicinal Chemistry, 2012, Pérez-Labrada, Karell et. al.
Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides
score: 1.1808459, Bioorganic & Medicinal Chemistry, 2012, Pérez-Labrada, Karell et. al.
Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides
score: 1.1808459, Bioorganic & Medicinal Chemistry, 2012, Pérez-Labrada, Karell et. al.
Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6')-Ib-cr gene.
score: 1.180753, Antimicrobial agents and chemotherapy, 2012, Ruiz, Elena et. al.
Anti-tumor Promoting Diterpenes from the Stem Bark of Thuja standishii (Cupressaceae)
score: 1.1806655, Bioorganic & Medicinal Chemistry, 2001, Iwamoto, Manabu et. al.
Synthesis and Biological Activity of 1-Phenylsulfonyl-4-Phenylsulfonylaminopyrrolidine Derivatives as Thromboxane A 2 Receptor Antagonists
score: 1.1806139, Bioorganic & Medicinal Chemistry, 2002, Marusawa, Hiroshi et. al.
Cadaverine suppresses persistence to carboxypenicillins in Pseudomonas aeruginosa PAO1.
score: 1.1805628, Antimicrobial agents and chemotherapy, 2010, Manuel, Jerrylynn; Zhanel, George G; de Kievit, Teresa
From selection to caged aptamers: Identification of light-dependent ssDNA aptamers targeting cytohesin
score: 1.1804285, Bioorganic & Medicinal Chemistry Letters, 2009, Mayer, Günter et. al.
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues
score: 1.1803604, Bioorganic & Medicinal Chemistry, 2012, Mostert, Samantha et. al.
In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci.
score: 1.1803395, Antimicrobial agents and chemotherapy, 2001, Singh, K V; Malathum, K; Murray, B E
Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus.
score: 1.1802117, Antimicrobial agents and chemotherapy, 1998, Aubry-Damon, H; Soussy, C J; Courvalin, P
Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugs.
score: 1.1800693, Antimicrobial agents and chemotherapy, 1998, Delling, U; Raymond, M; Schurr, E
Neutral and charged phosphine/scorpionate copper(I) complexes: Effects of ligand assembly on their antiproliferative activity
score: 1.180009, European Journal of Medicinal Chemistry, 2013, Porchia, Marina et. al.
Neutral and charged phosphine/scorpionate copper(I) complexes: Effects of ligand assembly on their antiproliferative activity
score: 1.180009, European Journal of Medicinal Chemistry, 2013, Porchia, Marina et. al.
Evaluation of ceftaroline activity versus ceftriaxone against clinical isolates of Streptococcus pneumoniae with various susceptibilities to cephalosporins in an in vitro pharmacokinetic/pharmacodynamic model.
score: 1.1800044, Antimicrobial agents and chemotherapy, 2012, Steed, Molly E et. al.
Iantherans A and B, unique dimeric polybrominated benzofurans as Na,K-ATPase inhibitors from a marine sponge, Ianthella sp.
score: 1.1799388, Bioorganic & Medicinal Chemistry, 2001, Okamoto, Yoshihiro et. al.
Pharmacokinetics of oral acyclovir in neonates and in infants: a population analysis.
score: 1.179914, Antimicrobial agents and chemotherapy, 2001, Tod, M et. al.
Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2- b]thioxanthen-6-ones and Pyrano[2,3- c]thioxanthen-7-ones
score: 1.179893, Bioorganic & Medicinal Chemistry, 2001, Kostakis, Ioannis K. et. al.
Countrywide spread of CTX-M-3 extended-spectrum beta-lactamase-producing microorganisms of the family Enterobacteriaceae in Poland.
score: 1.1798804, Antimicrobial agents and chemotherapy, 2002, Baraniak, Anna et. al.
Effect of γ-hydroxypropano deoxyguanosine, the major acrolein-derived adduct, on monomolecular quadruplex structure of telomeric repeat d(TTAGGG) 4
score: 1.1798124, Bioorganic & Medicinal Chemistry Letters, 2004, D’Isa, Giuliana et. al.
Enhancement of apoptosis of THP-1 cells infected with Mycobacterium tuberculosis by inhalable microparticles and relevance to bactericidal activity.
score: 1.1798033, Antimicrobial agents and chemotherapy, 2007, Yadav, Awadh Bihari; Misra, Amit
Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents
score: 1.1797441, European Journal of Medicinal Chemistry, 2010, Hoonur, Rekha S. et. al.
In vitro model of mycobacterial growth arrest using nitric oxide with limited air.
score: 1.1797416, Antimicrobial agents and chemotherapy, 2009, Hussain, Syed et. al.
Enhancing solid phase synthesis by a noncovalent protection strategy-efficient coupling of rhodamine to resin-bound peptide nucleic acids
score: 1.1796716, Bioorganic & Medicinal Chemistry Letters, 1999, Mayfield, Lynn D.; Corey, David R.
Antistaphylococcal activity of dalbavancin, an experimental glycopeptide.
score: 1.1796268, Antimicrobial agents and chemotherapy, 2005, Lin, Gengrong et. al.
Conformational organizations of G-quadruplexes composed of d(G 4T n ) 3G 4
score: 1.1795413, Bioorganic & Medicinal Chemistry Letters, 2010, Wong, Wan Chi et. al.
The retro-mannich cleavage of δ 1,δ 1′-tryptophan dimers
score: 1.1794122, Bioorganic & Medicinal Chemistry, 1998, Biggs, Bluegrass; Presley, Alice L.; Van Vranken, David L.
Comparative QSAR studies on substituted bis-(acridines) and bis-(phenazines)-carboxamides: a new class of anticancer agents
score: 1.1793624, Bioorganic & Medicinal Chemistry, 2000, Garg, Rajni; Denny, William A; Hansch, Corwin
Synthesis and protonation behavior of a water-soluble N-fused porphyrin: Conjugation with an oligoarginine by click chemistry
score: 1.1792351, Bioorganic & Medicinal Chemistry Letters, 2009, Ikawa, Yoshiya et. al.
A topological substructural approach applied to the computational prediction of rodent carcinogenicity
score: 1.1791911, Bioorganic & Medicinal Chemistry, 2005, Helguera, Aliuska Morales et. al.
Inhibitory effect of aureobasidin A on Toxoplasma gondii.
score: 1.1790385, Antimicrobial agents and chemotherapy, 2005, Sonda, Sabrina et. al.
Identification of a streptogramin A acetyltransferase gene in the chromosome of Yersinia enterocolitica.
score: 1.1789864, Antimicrobial agents and chemotherapy, 2000, Seoane, A; García Lobo, J M
An efficient, convenient synthesis of novel medium-sized 13 H-dibenzo[ d, h][1,3,7]oxadiazecine-8,14-dione macrolides as anticipated antineoplastic agents
score: 1.1789562, Bioorganic & Medicinal Chemistry, 2002, Abdel-Hafez, Atef Abdel-Monem
Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro.
score: 1.1789147, Antimicrobial agents and chemotherapy, 2008, Purfield, Anne E; Tidwell, Richard R; Meshnick, Steven R
Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.
score: 1.1788313, Antimicrobial agents and chemotherapy, 2001, Pérez-Victoria, J M et. al.
Synthesis and structure analysis of cyclodehydration product of piroxicam: A metabolite detected in dogs and monkeys
score: 1.1786591, European Journal of Medicinal Chemistry, 2009, Pal, Sarbani et. al.
Identification of a chromosome-borne expanded-spectrum class a beta-lactamase from Erwinia persicina.
score: 1.1786532, Antimicrobial agents and chemotherapy, 2002, Vimont, Sophie et. al.
Comparative in vitro susceptibilities of 396 unusual anaerobic strains to tigecycline and eight other antimicrobial agents.
score: 1.1786216, Antimicrobial agents and chemotherapy, 2006, Goldstein, Ellie J C et. al.
Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid
score: 1.1784766, European Journal of Medicinal Chemistry, 2005, Ammazzalorso, Alessandra et. al.
Stereoselective synthesis of 11Z-9-Demethyl-9-benzyl- and 9-phenyl-retinals and their interaction with bovine opsin
score: 1.1784094, Bioorganic & Medicinal Chemistry Letters, 1998, Wada, Akimori et. al.
Antipneumococcal activity of dalbavancin compared to other agents.
score: 1.1783458, Antimicrobial agents and chemotherapy, 2005, Lin, Gengrong et. al.
Global transcriptional response of Bacillus subtilis to treatment with subinhibitory concentrations of antibiotics that inhibit protein synthesis.
score: 1.1783432, Antimicrobial agents and chemotherapy, 2005, Lin, Janine T et. al.
In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates.
score: 1.178237, Antimicrobial agents and chemotherapy, 2011, Mishra, Nagendra N et. al.
Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.
score: 1.1781897, Bioorganic & Medicinal Chemistry, 2006, Laurent, Dominique et. al.
Neuronal nicotinic receptors and ligands
score: 1.1781475, Bioorganic & Medicinal Chemistry Letters, 2004,
In vitro selection of a photoresponsive RNA aptamer to hemin
score: 1.1781461, Bioorganic & Medicinal Chemistry Letters, 2010, Liu, Mingzhe; Jinmei, Hiroshi; Abe, Hiroshi; Ito, Yoshihiro
Deciphering the magainin resistance process of Escherichia coli strains in light of the cytosolic proteome.
score: 1.1780778, Antimicrobial agents and chemotherapy, 2012, Maria-Neto, Simone et. al.
Oral cimetidine prolongs clarithromycin absorption.
score: 1.1780037, Antimicrobial agents and chemotherapy, 1998, Amsden, G W; Cheng, K L; Peloquin, C A; Nafziger, A N
Cethromycin-mediated protection against the plague pathogen Yersinia pestis in a rat model of infection and comparison with levofloxacin.
score: 1.177938, Antimicrobial agents and chemotherapy, 2011, Rosenzweig, Jason A et. al.
Inhibition of duck hepatitis B virus replication by 9-(2-phosphonylmethoxyethyl)adenine, an acyclic phosphonate nucleoside analogue.
score: 1.1778892, Antimicrobial agents and chemotherapy, 1998, Nicoll, A J et. al.
Synthesis, stereochemical assignments, and biological activities of homoisoflavonoids
score: 1.1778504, Bioorganic & Medicinal Chemistry, 2006, Siddaiah, Vidavalur et. al.
Combinatorial chemistry in drug research from a new vantage point
score: 1.1778457, Bioorganic & Medicinal Chemistry, 1997, Maehr, Hubert
Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of the complexes [M(dmphen)(CO 3)]·H 2O [M = Pt(II), Pd(II)]
score: 1.177833, European Journal of Medicinal Chemistry, 2010, Gao, En-jun et. al.
Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors
score: 1.1777885, Bioorganic & Medicinal Chemistry, 2012, Stavitskaya, Lidiya et. al.
Unified QSAR approach to antimicrobials. Part 3: First multi-tasking QSAR model for Input-Coded prediction, structural back-projection, and complex networks clustering of antiprotozoal compounds
score: 1.1777782, Bioorganic & Medicinal Chemistry, 2008, Prado-Prado, Francisco J. et. al.
Synthesis of a [2- Pyridinyl- 18F]-labelled fluoro derivative of (−)-Cytisine as a candidate radioligand for brain nicotinic α4β2 receptor imaging with PET
score: 1.1777254, Bioorganic & Medicinal Chemistry, 2003, Roger, Gaëlle et. al.
Cytotoxic diterpenoids from two lianas from the Suriname rainforest
score: 1.1776466, Bioorganic & Medicinal Chemistry, 2005, Adou, Eba et. al.
DNA damage and biological effects induced by photosensitization with new N 1-unsubstituted furo[2,3- h]quinolin-2(1 H)-ones
score: 1.177621, Bioorganic & Medicinal Chemistry, 2002, Marzano, Cristina et. al.
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy
score: 1.1774554, Bioorganic & Medicinal Chemistry, 2012, He, Jie et. al.
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy
score: 1.1774554, Bioorganic & Medicinal Chemistry, 2012, He, Jie et. al.
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy
score: 1.1774554, Bioorganic & Medicinal Chemistry, 2012, He, Jie et. al.
New substituted 9-alkylpurines as adenosine receptor ligands
score: 1.177405, Bioorganic & Medicinal Chemistry, 1998, Camaioni, Emidio et. al.
Enzymatic and hyperglycemia stability of chemically modified insulins with hydrophobic acyl groups
score: 1.1773454, Bioorganic & Medicinal Chemistry Letters, 2004, Nakashima, Kentaro et. al.
Randomized controlled trial of sequential intravenous (i.v.) and oral moxifloxacin compared with sequential i.v. and oral co-amoxiclav with or without clarithromycin in patients with community-acquired pneumonia requiring initial parenteral treatment.
score: 1.1773176, Antimicrobial agents and chemotherapy, 2002, Finch, R et. al.
Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives
score: 1.1773146, European Journal of Medicinal Chemistry, 2004, Delmas, Florence et. al.
Concise synthesis and voltammetric studies of dielsiquinone, a cytotoxic azaanthraquinone
score: 1.17728, Bioorganic & Medicinal Chemistry Letters, 2005, Brisach-Wittmeyer, Anne et. al.
Lead optimization of 7-benzyloxy 2-(4′-pyridylmethyl)thio isoflavone aromatase inhibitors
score: 1.1771576, Bioorganic & Medicinal Chemistry, 2005, Su, Bin et. al.
Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3- h]quinolin-2(1 H)-one-9-carboxylic acid and its esters
score: 1.1771478, Bioorganic & Medicinal Chemistry, 2003, Zhang, Qian et. al.
Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR–Tat
score: 1.1770537, Bioorganic & Medicinal Chemistry, 2006, Yajima, Saki et. al.
In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.
score: 1.1769685, Antimicrobial agents and chemotherapy, 2006, Jones-Brando, Lorraine et. al.
Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT) 2
score: 1.1768883, Bioorganic & Medicinal Chemistry, 2003, Mazzini, Stefania et. al.
Raltegravir is a substrate for SLC22A6: a putative mechanism for the interaction between raltegravir and tenofovir.
score: 1.1768449, Antimicrobial agents and chemotherapy, 2011, Moss, Darren M et. al.
Prevalence of blaZ gene types and the inoculum effect with cefazolin among bloodstream isolates of methicillin-susceptible Staphylococcus aureus.
score: 1.1768295, Antimicrobial agents and chemotherapy, 2012, Livorsi, D J et. al.
Impact of spores on the comparative efficacies of five antibiotics for treatment of Bacillus anthracis in an in vitro hollow fiber pharmacodynamic model.
score: 1.1767985, Antimicrobial agents and chemotherapy, 2012, Louie, Arnold et. al.
Combinations of lysostaphin with beta-lactams are synergistic against oxacillin-resistant Staphylococcus epidermidis.
score: 1.1767227, Antimicrobial agents and chemotherapy, 2002, Kiri, Nandini; Archer, Gordon; Climo, Michael W
Variation of protein binding cavity volume and ligand volume in protein–ligand complexes
score: 1.1767118, Bioorganic & Medicinal Chemistry Letters, 2009, Saranya, N.; Selvaraj, S.
Structure of pentasaccharide of glycopeptide from TIME-EA4, N-glycoprotein in silkworm diapause eggs
score: 1.176677, Bioorganic & Medicinal Chemistry Letters, 2004, Pitchayawasin, Suthasinee et. al.
Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis.
score: 1.1766411, Antimicrobial agents and chemotherapy, 2007, Nelson, Jennifer L et. al.
Trigoxyphins H and I: Two new daphnane diterpenoids from Trigonostemon xyphophylloides
score: 1.1766034, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Biao et. al.
Trigoxyphins H and I: Two new daphnane diterpenoids from Trigonostemon xyphophylloides
score: 1.1766034, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Biao et. al.
An efficient and versatile approach for the construction of oligonucleotide microarrays
score: 1.1765651, Bioorganic & Medicinal Chemistry Letters, 2006, Mahajan, S.; Kumar, P.; Gupta, K.C.
Synthesis and characterization of copper(II) and zinc(II)–based potential chemotherapeutic compounds: Their biological evaluation viz. DNA binding profile, cleavage and antimicrobial activity
score: 1.176526, European Journal of Medicinal Chemistry, 2012, Tabassum, Sartaj et. al.
Mechanism and suppression of lysostaphin resistance in oxacillin-resistant Staphylococcus aureus.
score: 1.1765198, Antimicrobial agents and chemotherapy, 2001, Climo, M W; Ehlert, K; Archer, G L
The effect of linker length on binding affinity of a photoswitchable molecular glue for DNA
score: 1.176513, Bioorganic & Medicinal Chemistry, 2009, Dohno, Chikara et. al.
In vitro potency of various polymyxin B components.
score: 1.1765026, Antimicrobial agents and chemotherapy, 2011, Tam, Vincent H; Cao, Henry; Ledesma, Kimberly R; Hu, Ming
19F NMR detection of the complex between amantadine and the receptor portion of the influenza A M2 ion channel in DPC micelles
score: 1.1765013, Bioorganic & Medicinal Chemistry Letters, 2007, Kolocouris, Antonios et. al.
Future directions in phosphodiesterase drug discovery
score: 1.1764798, Bioorganic & Medicinal Chemistry Letters, 2012, DeNinno, Michael P.
Future directions in phosphodiesterase drug discovery
score: 1.1764798, Bioorganic & Medicinal Chemistry Letters, 2012, DeNinno, Michael P.
Future directions in phosphodiesterase drug discovery
score: 1.1764798, Bioorganic & Medicinal Chemistry Letters, 2012, DeNinno, Michael P.
Triple helix stabilization by covalently linked DNA–bisbenzimidazole conjugate synthesized by maleimide–thiol coupling chemistry
score: 1.176331, Bioorganic & Medicinal Chemistry, 2006, Jain, Akash K.; Awasthi, Satish Kumar; Tandon, Vibha
Nanodroplet profiling of enzymatic activities in a microarray
score: 1.1762034, Bioorganic & Medicinal Chemistry Letters, 2005, Uttamchandani, Mahesh et. al.
Prevalence and molecular characterization of extended-spectrum-β-lactamase-producing Enterobacteriaceae in a pediatric patient population.
score: 1.1761891, Antimicrobial agents and chemotherapy, 2012, Chandramohan, Lakshmi; Revell, Paula A
Substitutions in the eyelet region disrupt cefepime diffusion through the Escherichia coli OmpF channel.
score: 1.1760924, Antimicrobial agents and chemotherapy, 2000, Simonet, V; Malléa, M; Pagès, J M
New minor taxanes analogues from the needles of Taxus canadensis
score: 1.1760922, Bioorganic & Medicinal Chemistry, 2003, Shi, Qing Wen et. al.
Synthesis of [14,14,14- 2H 3] 12-hydroxytetradecanoic acid and [13,14- 2H 2] 11-hydroxytetradecanoic acid useful as tracers to study a (11 E)-desaturation reaction in Spodoptera littoralis
score: 1.1760725, Bioorganic & Medicinal Chemistry, 1996, Navarro, Isabel; Fabriás, Gemma; Camps, Francisco
Nonylphenolethoxylates as malarial chloroquine resistance reversal agents.
score: 1.1760601, Antimicrobial agents and chemotherapy, 2000, Crandall, I; Charuk, J; Kain, K C
Molecular diversity of peptidomimetics: Approaches to the solid-phase synthesis of peptidosulfonamides
score: 1.1759817, Bioorganic & Medicinal Chemistry, 1996, de Bont, Dries B.A.; Moree, Wilna J.; Liskamp, Rob M.J.
In vitro activities of a new lipopeptide, HMR 1043, against susceptible and resistant gram-positive isolates.
score: 1.1759668, Antimicrobial agents and chemotherapy, 2003, Bemer, Pascale et. al.
Synthesis of a bis-azido analogue of acromelic acid for radioisotope-free photoaffinity labeling and biochemical studies
score: 1.1759627, Bioorganic & Medicinal Chemistry Letters, 2006, Sun, Pi; Wang, Guang Xing; Furuta, Kyoji; Suzuki, Masaaki
Synthesis and activity of 1- N-iminosugar inhibitors, siastatin B analogues for α- N-acetylgalactosaminidase and β- N-acetylglucosaminidase
score: 1.1757918, Bioorganic & Medicinal Chemistry, 1996, Nishimura, Yoshio et. al.
Human serum albumin as a catalyst of RNA cleavage: N-Homocysteinylation and N-phosphorylation by oligonucleotide affinity reagent alter the reactivity of the protein
score: 1.175749, Bioorganic & Medicinal Chemistry Letters, 2008, Gerasimova, Yuliya V. et. al.
Mechanisms of macrolide resistance in clinical pneumococcal isolates in France.
score: 1.1756843, Antimicrobial agents and chemotherapy, 2001, Fitoussi, F; Doit, C; Geslin, P; Brahimi, N; Bingen, E
N-methyl threonine analogues of deglycobleomycin A 2: Synthesis and evaluation
score: 1.1755828, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L.; Teramoto, Shuji; Cai, Hui
N-methyl threonine analogues of deglycobleomycin A 2: Synthesis and evaluation
score: 1.1755828, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L.; Teramoto, Shuji; Cai, Hui
In vitro antibiotic synergy in extensively drug-resistant Acinetobacter baumannii: the effect of testing by time-kill, checkerboard, and Etest methods.
score: 1.175463, Antimicrobial agents and chemotherapy, 2011, Tan, Thean Yen et. al.
Synthesis and primary cytotoxicity evaluation of new 5-nitroindole-2,3-dione derivatives
score: 1.1753472, European Journal of Medicinal Chemistry, 2002, Karalı, Nilgün
A fluorescent redox sensor with tuneable oxidation potential
score: 1.1753293, Bioorganic & Medicinal Chemistry Letters, 2010, Kierat, Radoslaw M.; Thaler, Birgit M.B.; Krämer, Roland
Synthesis, X-ray structures and cytotoxic activity of platinum(II), palladium(II) and copper(II) complexes with chelating ligands
score: 1.1753033, European Journal of Medicinal Chemistry, 2010, Budzisz, Elzbieta et. al.
In vitro activities of doripenem and comparator agents against 364 anaerobic clinical isolates.
score: 1.1752394, Antimicrobial agents and chemotherapy, 2005, Wexler, Hannah M; Engel, Adrian E; Glass, Daniel; Li, Calida
Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates
score: 1.1752177, Bioorganic & Medicinal Chemistry Letters, 2012, Pathuri, Gopal et. al.
Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates
score: 1.1752177, Bioorganic & Medicinal Chemistry Letters, 2012, Pathuri, Gopal et. al.
Population pharmacokinetics of ceftizoxime administered by continuous infusion in clinically ill adult patients.
score: 1.1752066, Antimicrobial agents and chemotherapy, 1998, Facca, B; Frame, B; Triesenberg, S
Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats.
score: 1.1751412, Antimicrobial agents and chemotherapy, 2000, Ohtani, H et. al.
Anti-inflammatory, analgesic and antiamoebic activity evaluation of pyrimido[1,6- a]benzimidazole derivatives synthesized by the reaction of ketoisothiocyanates with mono and diamines
score: 1.1751175, European Journal of Medicinal Chemistry, 2002, Sondhi, Sham M et. al.
Activity of cecropin A-melittin hybrid peptides against colistin-resistant clinical strains of Acinetobacter baumannii: molecular basis for the differential mechanisms of action.
score: 1.1750683, Antimicrobial agents and chemotherapy, 2006, Saugar, José María et. al.
N-Benzyl-2-chloroindole-3-carboxylic acids as potential anti-inflammatory agents. Synthesis and screening for the effects on human neutrophil functions and on COX1/COX2 activity
score: 1.1750287, European Journal of Medicinal Chemistry, 2004, Andreani, Aldo et. al.
Knowledge-based analysis of multi-potent G-protein coupled receptors ligands
score: 1.1749969, European Journal of Medicinal Chemistry, 2010, Faure, Patricia et. al.
An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli
score: 1.1749792, Bioorganic & Medicinal Chemistry, 2012, Blažek, Jiří et. al.
Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system
score: 1.1749662, Bioorganic & Medicinal Chemistry Letters, 2005, Demura, Makoto et. al.
Synthesis of 3-Substituted Benzamides and 5-Substituted Isoquinolin-1(2H)-ones and Preliminary Evaluation as Inhibitors of Poly(ADP-ribose)polymerase (PARP)
score: 1.1749561, Bioorganic & Medicinal Chemistry, 1998, Watson, Corrine Y. et. al.
Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones
score: 1.1748028, Bioorganic & Medicinal Chemistry, 2006, Vicini, Paola et. al.
Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives based on ethidium
score: 1.174788, Bioorganic & Medicinal Chemistry, 2003, Luedtke, Nathan W; Liu, Qi; Tor, Yitzhak
Effects of vitamins, coenzymes and amino acids on reactions of homolytic cleavage of the O-glycoside bond in carbohydrates
score: 1.1747668, Bioorganic & Medicinal Chemistry Letters, 2006, Shadyro, O.I. et. al.
Enoyl-CoA hydratase
score: 1.1747608, Bioorganic & Medicinal Chemistry, 2003, Agnihotri, Gautam; Liu, Hung-wen
gem-Diamine 1- N-iminosugars of l-fucose-type, the extremely potent l-fucosidase inhibitors
score: 1.1746523, Bioorganic & Medicinal Chemistry, 2000, Shitara, Eiki et. al.
Antibacterial chalcones––bioisosteric replacement of the 4′-hydroxy group
score: 1.1746443, Bioorganic & Medicinal Chemistry, 2004, Nielsen, Simon Feldbæk et. al.
Reactions of chloride salts of 7-amino-9-ethylguanine and 1-amino-3-methylbenzimidazoles with lead(IV) acetate: Formation of 8-aza-9-ethylguanine and 1-methyl-1 H-benzotriazoles
score: 1.1745123, Bioorganic & Medicinal Chemistry Letters, 1999, Kaiya, Toyo; Aoyama, Shinsuke; Kohda, Kohfuku
New derivatives of xanthenone-4-acetic acid: Synthesis, pharmacological profile and effect on TNF-α and NO production by human immune cells
score: 1.1744794, Bioorganic & Medicinal Chemistry, 2006, Gobbi, Silvia et. al.
In silico studies on the substrate specificity of an l-arabinose isomerase from Bacillus licheniformis
score: 1.1744697, Bioorganic & Medicinal Chemistry Letters, 2010, Prabhu, Ponnandy; Jeya, Marimuthu; Lee, Jung-Kul
Targeting Essential Genes in Salmonella enterica Serovar Typhimurium with Antisense Peptide Nucleic Acid.
score: 1.1744286, Antimicrobial agents and chemotherapy, 2012, Soofi, Muhammad A; Seleem, Mohamed N
Hybrids of ravuconazole: Synthesis and biological evaluation
score: 1.1743655, European Journal of Medicinal Chemistry, 2012, Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Hybrids of ravuconazole: Synthesis and biological evaluation
score: 1.1743655, European Journal of Medicinal Chemistry, 2012, Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells
score: 1.1742063, Bioorganic & Medicinal Chemistry, 2012, Yang, Zunhua et. al.
Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells
score: 1.1742063, Bioorganic & Medicinal Chemistry, 2012, Yang, Zunhua et. al.
Non-thiazolidinedione antihyperglycaemic agents. Part 3: the effects of stereochemistry on the potency of α-methoxy-β-phenylpropanoic acids
score: 1.1740509, Bioorganic & Medicinal Chemistry, 1999, Haigh, David et. al.
Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonates.
score: 1.1740296, Antimicrobial agents and chemotherapy, 2011, Benaboud, Sihem et. al.
A unique unnatural base pair between a C analogue, pseudoisocytosine, and an A analogue, 6-methoxypurine, in replication
score: 1.1738853, Bioorganic & Medicinal Chemistry Letters, 2002, Hirao, Ichiro et. al.
In vitro double and triple synergistic activities of Polymyxin B, imipenem, and rifampin against multidrug-resistant Acinetobacter baumannii.
score: 1.1738373, Antimicrobial agents and chemotherapy, 2004, Yoon, Jimmy et. al.
Translocation of an Aib-containing peptide through cell membranes
score: 1.1737878, Bioorganic & Medicinal Chemistry Letters, 2008, Wada, Shun-ichi et. al.
Two 2-hydroxy-3-alkyl-1,4-naphthoquinones with in vitro and in vivo activities against Toxoplasma gondii.
score: 1.1737515, Antimicrobial agents and chemotherapy, 1998, Khan, A A; Nasr, M; Araujo, F G
Design and synthesis of conformationally frozen peptide nucleic acid backbone: chiral piperidine PNA as a hexitol nucleic acid surrogate
score: 1.1736681, Bioorganic & Medicinal Chemistry Letters, 2004, Lonkar, Pallavi S.; Kumar, Vaijayanti A.
Carbonic anhydrase inhibitors
score: 1.1736166, Bioorganic & Medicinal Chemistry, 1999, Borras, Joaquin et. al.
Antibiofilm activity of GlmU enzyme inhibitors against catheter-associated uropathogens.
score: 1.1734752, Antimicrobial agents and chemotherapy, 2006, Burton, Euan et. al.
Noncovalent inhibition of 20S proteasome by pegylated dimerized inhibitors
score: 1.1734191, European Journal of Medicinal Chemistry, 2012, Maréchal, Xavier et. al.
Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine.
score: 1.1733945, Antimicrobial agents and chemotherapy, 1999, de Muys, J M et. al.
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme
score: 1.1733621, European Journal of Medicinal Chemistry, 2012, Biava, Mariangela et. al.
Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
score: 1.1733295, Antimicrobial agents and chemotherapy, 2004, Keith, Kathy A et. al.
Novel pentadecenyl tetrazole enhances susceptibility of methicillin-resistant Staphylococcus aureus biofilms to gentamicin.
score: 1.1733289, Antimicrobial agents and chemotherapy, 2011, Olson, Krista M et. al.
Chemically engineered extracts: Bioactivity alteration through sulfonylation
score: 1.1733134, Bioorganic & Medicinal Chemistry Letters, 2009, Salazar, Mario O. et. al.
Antimicrobial activity and spectrum of cefovecin, a new extended- spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America.
score: 1.1730974, Antimicrobial agents and chemotherapy, 2006, Stegemann, M R et. al.
Novel Non-Steroidal/Non-Anilide Type Androgen Antagonists with an Isoxazolone Moiety
score: 1.173075, Bioorganic & Medicinal Chemistry, 2002, Ishioka, Toshiyasu et. al.
Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: antimicrobial susceptibility patterns from the SENTRY antimicrobial Surveillance Program (United States and Canada, 1997).
score: 1.1730745, Antimicrobial agents and chemotherapy, 1999, Doern, G V; Jones, R N; Pfaller, M A; Kugler, K
Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives
score: 1.1729825, European Journal of Medicinal Chemistry, 2003, Dabak, Kadir; Sezer, Özkan; Akar, Ahmet; Anaç, Olcay
Antimicrobial activity of intraurethrally administered probiotic Lactobacillus casei in a murine model of Escherichia coli urinary tract infection.
score: 1.1729253, Antimicrobial agents and chemotherapy, 2001, Asahara, T; Nomoto, K; Watanuki, M; Yokokura, T
Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine
score: 1.1727542, Bioorganic & Medicinal Chemistry, 1999, Kaminski, James J. et. al.
Binding free energy calculation for duocarmycin/DNA complex based on the QPLD-derived partial charge model
score: 1.1727208, Bioorganic & Medicinal Chemistry Letters, 2008, Zhong, Haizhen et. al.
Hybrids of ravuconazole: Synthesis and biological evaluation
score: 1.1726315, European Journal of Medicinal Chemistry, 2012, Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Oligoribonucleotides containing 8-oxo-7,8-dihydro-guanosine and 8-oxo-7,8-dihydro-2′-O-methylguanosine: Synthesis and base pairing properties
score: 1.1725794, Bioorganic & Medicinal Chemistry Letters, 1998, Kim, Sang Kook et. al.
Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria.
score: 1.1725497, Antimicrobial agents and chemotherapy, 1999, Kashuba, A D; Nafziger, A N; Drusano, G L; Bertino, J S
Absolute configuration determination of isoflavan-4-ol stereoisomers
score: 1.1724614, Bioorganic & Medicinal Chemistry Letters, 2010, Kim, Mihyang; Won, Dongho; Han, Jaehong
Comparative in vitro activities of AC98-6446, a novel semisynthetic glycopeptide derivative of the natural product mannopeptimycin alpha, and other antimicrobial agents against gram-positive clinical isolates.
score: 1.1724393, Antimicrobial agents and chemotherapy, 2004, Petersen, Peter J et. al.
Convergent evolutionary analysis identifies significant mutations in drug resistance targets of Mycobacterium tuberculosis.
score: 1.1723573, Antimicrobial agents and chemotherapy, 2008, Hazbón, Manzour Hernando et. al.
Chemoenzymatic synthesis and biological evaluation of 2- and 3-hydroxypyridine derivatives against Leishmania mexicana
score: 1.1723164, Bioorganic & Medicinal Chemistry, 2012, García Liñares, Guadalupe et. al.
Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme
score: 1.1722142, Bioorganic & Medicinal Chemistry, 2006, Kalek, Marcin et. al.
Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45
score: 1.172188, Bioorganic & Medicinal Chemistry, 1997, Beers, Scott A. et. al.
Clinical carbapenem-resistant Acinetobacter baylyi strain coharboring blaSIM-1 and blaOXA-23 from China.
score: 1.1721145, Antimicrobial agents and chemotherapy, 2011, Zhou, Zhihui et. al.
Distribution of mef(A) in gram-positive bacteria from healthy Portuguese children.
score: 1.1720719, Antimicrobial agents and chemotherapy, 2002, Luna, Vicki A et. al.
Concordance between two phenotypic assays and ultradeep pyrosequencing for determining HIV-1 tropism.
score: 1.1719042, Antimicrobial agents and chemotherapy, 2011, Saliou, Adrien et. al.
Detection of aptamer–protein interactions using QCM and electrochemical indicator methods
score: 1.1717945, Bioorganic & Medicinal Chemistry Letters, 2005, Hianik, Tibor et. al.
Outer surface modification of synthetic multifunctional pores
score: 1.171709, Bioorganic & Medicinal Chemistry, 2004, Talukdar, Pinaki et. al.
Modelling studies on the binding of substrate and inhibitor to the active site of human sorbitol dehydrogenase
score: 1.1716903, Bioorganic & Medicinal Chemistry Letters, 2000, Darmanin, Connie; El-Kabbani, Ossama
Chemical inducers of dimerization: The atomic structure of FKBP12-FK1012A-FKBP12
score: 1.171555, Bioorganic & Medicinal Chemistry Letters, 1998, Wayne Schultz, L.; Clardy, Jon
Synthesis of calcium phosphate-binding liposome for drug delivery
score: 1.1714549, Bioorganic & Medicinal Chemistry Letters, 2009, Anada, Takahisa et. al.
Synthesis and 5-HT 1A, 5-HT 2A receptor activity of new β-tetralonohydantoins
score: 1.1714272, European Journal of Medicinal Chemistry, 2005, Byrtus, Hanna et. al.
Identification of structural components associated with cytostatic activity in MCF-7 but not in MDA-MB-231 cells
score: 1.1714168, Bioorganic & Medicinal Chemistry, 2003, Cunningham, Albert R; Cunningham, Suzanne L; Day, Billy W
First report of plasmid-mediated resistance to quinolones and cefotaxime in an Enterobacter cloacae strain isolated from an outpatient in Brazil.
score: 1.1712237, Antimicrobial agents and chemotherapy, 2007, Minarini, Luciene A R; Gales, Ana C; Darini, Ana Lucia C
Pharmacokinetic study of tenofovir disoproxil fumarate combined with rifampin in healthy volunteers.
score: 1.1712035, Antimicrobial agents and chemotherapy, 2005, Droste, J A H et. al.
Chlorin-PEI-labeled cellulose nanocrystals: Synthesis, characterization and potential application in PDT
score: 1.1711819, Bioorganic & Medicinal Chemistry Letters, 2012, Drogat, Nicolas et. al.
Chlorin-PEI-labeled cellulose nanocrystals: Synthesis, characterization and potential application in PDT
score: 1.1711819, Bioorganic & Medicinal Chemistry Letters, 2012, Drogat, Nicolas et. al.
Chlorin-PEI-labeled cellulose nanocrystals: Synthesis, characterization and potential application in PDT
score: 1.1711819, Bioorganic & Medicinal Chemistry Letters, 2012, Drogat, Nicolas et. al.
Novel coumarin-3-( N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1
score: 1.1710817, Bioorganic & Medicinal Chemistry, 2005, Reddy, Natala Srinivasa et. al.
L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide.
score: 1.1710046, Antimicrobial agents and chemotherapy, 2012, Zhong, Maohua et. al.
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
score: 1.1709644, Antimicrobial agents and chemotherapy, 2004, Cardoso, Rosilene Fressatti et. al.
One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bio-evaluation as antimalarial and anti-HIV agents
score: 1.1707908, European Journal of Medicinal Chemistry, 2012, Fatima, Seerat et. al.
Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein.
score: 1.1704559, Antimicrobial agents and chemotherapy, 2005, Kaatz, Glenn W; McAleese, Fionnuala; Seo, Susan M
Hydrophobic derivatives of 2-amino-2-deoxy- d-glucitol-6-phosphate: A new type of d-Glucosamine-6-phosphate synthase inhibitors with antifungal action
score: 1.1703827, Bioorganic & Medicinal Chemistry, 2003, Janiak, Agnieszka M et. al.
Metabolism of Analogues of Coproporphyrinogen-III with Modified Side Chains: Implications for Binding at the Active Site of Coproporphyrinogen Oxidase
score: 1.1703679, Bioorganic & Medicinal Chemistry Letters, 2002, Lash, Timothy D et. al.
Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania.
score: 1.1703626, Antimicrobial agents and chemotherapy, 2004, Tenover, Fred C et. al.
Reactions of α-hydroxyethyl radicals with flavonoids of various structures
score: 1.1703308, Bioorganic & Medicinal Chemistry Letters, 2005, Hryntsevich, I.B.; Shadyro, O.I.
Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies
score: 1.1703039, European Journal of Medicinal Chemistry, 2012, Tollas, Szilvia et. al.
Simple and convenient radiolabeling of proteins using a prelabeling-approach with thiol-DOTA
score: 1.1702272, Bioorganic & Medicinal Chemistry Letters, 2009, Wängler, Carmen et. al.
The electronic structure of human erythropoietin as an aid in the design of oxidation-resistant therapeutic proteins
score: 1.1700941, Bioorganic & Medicinal Chemistry Letters, 2006, Pichierri, Fabio
Susceptibility of Candida dubliniensis to salivary histatin 3.
score: 1.1700486, Antimicrobial agents and chemotherapy, 2003, Fitzgerald, Deirdre H; Coleman, David C; O'Connell, Brian C
Effects of Chemical Modification of Sphingomyelin Ammonium Group on Formation of Liquid-Ordered Phase
score: 1.1699498, Bioorganic & Medicinal Chemistry, 2012, Goretta, Sarah A. et. al.
Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds
score: 1.1698984, Bioorganic & Medicinal Chemistry, 2003, Parmar, Virinder S et. al.
Enhancement of vancomycin activity against biofilms by using ultrasound-targeted microbubble destruction.
score: 1.1698943, Antimicrobial agents and chemotherapy, 2011, He, Nianan et. al.
Synthesis of phosphono analogues of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate
score: 1.1698812, Bioorganic & Medicinal Chemistry, 1999, Page, Patrick; Blonski, Casimir; Périé, Jacques
Hyrtioreticulins A–E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
score: 1.1697773, Bioorganic & Medicinal Chemistry, 2012, Yamanokuchi, Rumi et. al.
Hyrtioreticulins A–E, indole alkaloids inhibiting the ubiquitin-activating enzyme from the marine sponge Hyrtios reticulatus
score: 1.1697773, Bioorganic & Medicinal Chemistry, 2012, Yamanokuchi, Rumi et. al.
Hyrtioreticulins A–E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
score: 1.1697773, Bioorganic & Medicinal Chemistry, 2012, Yamanokuchi, Rumi et. al.
Design and synthesis of substrates for newborn screening of Maroteaux–Lamy and Morquio A syndromes
score: 1.1696032, Bioorganic & Medicinal Chemistry Letters, 2010, Duffey, Trisha A. et. al.
Permeation and metabolism of a series of novel lipophilic ascorbic acid derivatives, 6- O-acyl-2- O-α- d-glucopyranosyl- l-ascorbic acids with a branched-acyl chain, in a human living skin equivalent model
score: 1.1694487, Bioorganic & Medicinal Chemistry Letters, 2004, Tai, Akihiro et. al.
2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE 2 antagonist
score: 1.1694372, Bioorganic & Medicinal Chemistry, 2001, Hallinan, E.Ann et. al.
Altered susceptibility of Candida glabrata bloodstream isolates to triazoles at clinically relevant pH values: comparison of the NCCLS M27-A2, Sensititre YeastOne, and Etest methods.
score: 1.1694211, Antimicrobial agents and chemotherapy, 2004, Pai, Manjunath P; Jones, Ariel L
Determination of hERG channel blockers using a decision tree
score: 1.169271, Bioorganic & Medicinal Chemistry, 2006, Gepp, Michael M.; Hutter, Michael C.
In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis.
score: 1.1691965, Antimicrobial agents and chemotherapy, 2006, Vera-Cabrera, Lucio et. al.
6-Aminoalkyloxazolo[4,5- b]pyridin-2(3 H)-ones: Synthesis and Evaluation of Antinoceptive Activity
score: 1.1691823, Bioorganic & Medicinal Chemistry, 1998, Savelon, L. et. al.
Influence of 2-Substituent on the Activity of Imidazo[1,2- a] Pyridine Derivatives Against Human Cytomegalovirus
score: 1.1691503, Bioorganic & Medicinal Chemistry, 2002, Mavel, Sylvie et. al.
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.
score: 1.1691471, Antimicrobial agents and chemotherapy, 2005, Wolter, Nicole et. al.
Synthesis and antioxidant, anti-inflammatory and gastroprotector activities of anethole and related compounds
score: 1.1691297, Bioorganic & Medicinal Chemistry, 2005, Freire, Rosemayre S. et. al.
In vitro interactions between amphotericin B, itraconazole, and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction models.
score: 1.1691054, Antimicrobial agents and chemotherapy, 2004, Te Dorsthorst, D T A et. al.
Combinatorial approaches to the prevention and treatment of HIV-1 infection.
score: 1.1689351, Antimicrobial agents and chemotherapy, 2011, Pirrone, Vanessa et. al.
Simultaneous determination of 12 beta-lactam antibiotics in human plasma by high-performance liquid chromatography with UV detection: application to therapeutic drug monitoring.
score: 1.168913, Antimicrobial agents and chemotherapy, 2011, Verdier, Marie-Clémence et. al.
Substrate/inhibition studies of bacteriophage T7 RNA polymerase with the 5′-triphosphate derivative of a ring-expanded (‘fat’) nucleoside possessing potent antiviral and anticancer activities
score: 1.1688891, Bioorganic & Medicinal Chemistry, 1999, Bretner, Maria et. al.
In vitro activity of the new triazole BMS-207147 against Aspergillus species in comparison with itraconazole and amphotericin B.
score: 1.1687651, Antimicrobial agents and chemotherapy, 2000, Moore, C B; Walls, C M; Denning, D W
Rapid detection of a molecular marker for chloroquine-resistant falciparum malaria.
score: 1.1687485, Antimicrobial agents and chemotherapy, 2002, Durand, Rémy et. al.
Cobalt, nickel, copper and zinc complexes with 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde Schiff bases: Antimicrobial, spectroscopic, thermal and fluorescence studies
score: 1.1687414, European Journal of Medicinal Chemistry, 2012, Singh, Kiran et. al.
Cobalt, nickel, copper and zinc complexes with 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde Schiff bases: Antimicrobial, spectroscopic, thermal and fluorescence studies
score: 1.1687414, European Journal of Medicinal Chemistry, 2012, Singh, Kiran et. al.
Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors
score: 1.1686929, European Journal of Medicinal Chemistry, 2012, Bruel, Amélie et. al.
New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor-α production inhibitors
score: 1.168631, European Journal of Medicinal Chemistry, 2001, Collin, Xavier et. al.
Novel sequence-responding fluorescent oligoDNA probe bearing a silylated pyrene molecule
score: 1.1686105, Bioorganic & Medicinal Chemistry Letters, 2007, Sekiguchi, Tohru et. al.
Predictive comparative QSAR modelling of (phenylpiperazinyl-alkyl) oxindoles as selective 5-HT 1A antagonists by stepwise regression, PCRA, FA-MLR and PLS techniques
score: 1.1684981, European Journal of Medicinal Chemistry, 2010, Adhikari, Nilanjan; Maiti, Milan K.; Jha, Tarun
Antipneumococcal and antistaphylococcal activities of ranbezolid (RBX 7644), a new oxazolidinone, compared to those of other agents.
score: 1.1684109, Antimicrobial agents and chemotherapy, 2003, Hoellman, Dianne B et. al.
Proveblue (methylene blue) as an antimalarial agent: in vitro synergy with dihydroartemisinin and atorvastatin.
score: 1.1683892, Antimicrobial agents and chemotherapy, 2012, Dormoi, Jérôme et. al.
Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis.
score: 1.1683568, Antimicrobial agents and chemotherapy, 2007, Müller, C et. al.
Artemisone uptake in Plasmodium falciparum-infected erythrocytes.
score: 1.1683389, Antimicrobial agents and chemotherapy, 2011, Pooley, Sophie et. al.
Reprint of “Inspired by flowers: Synthetic routes to scalemic deltamethrinic acid” [Bioorg. Med. Chem. 17 (2009) 2555–2575]
score: 1.1682978, Bioorganic & Medicinal Chemistry, 2009, Krief, Alain; Jeanmart, Stephane; Kremer, Adrian
Chalcogenoxanthylium photosensitizers for the photodynamic purging of blood-borne viral and bacterial pathogens
score: 1.1682393, Bioorganic & Medicinal Chemistry, 2005, Wagner, Stephen J. et. al.
IMP dehydrogenase from the protozoan parasite Toxoplasma gondii.
score: 1.1682295, Antimicrobial agents and chemotherapy, 2005, Sullivan, William J et. al.
Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate—caged SPP
score: 1.1681578, Bioorganic & Medicinal Chemistry Letters, 1998, Qiao, Lixin et. al.
Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen
score: 1.1680333, Bioorganic & Medicinal Chemistry, 2012, Miyano, Yuka et. al.
Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen
score: 1.1680333, Bioorganic & Medicinal Chemistry, 2012, Miyano, Yuka et. al.
Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen
score: 1.1680333, Bioorganic & Medicinal Chemistry, 2012, Miyano, Yuka et. al.
Stabilization of guanine quadruplex DNA by the binding of porphyrins with cationic side arms
score: 1.1680261, Bioorganic & Medicinal Chemistry, 2005, Yamashita, Takeshi; Uno, Tadayuki; Ishikawa, Yoshinobu
Potent non-peptidyl inhibitors of protein tyrosine phosphatase 1B
score: 1.168013, Bioorganic & Medicinal Chemistry, 1998, Taylor, Scott D. et. al.
Synthesis, characterization, and DNA-binding properties of the Ln(III) complexes with 6-hydroxy chromone-3-carbaldehyde-(2′-hydroxy) benzoyl hydrazone
score: 1.167918, Bioorganic & Medicinal Chemistry, 2006, Wang, Bao-dui; Yang, Zheng-Yin; Li, Tian-rong
Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus.
score: 1.1679045, Antimicrobial agents and chemotherapy, 2000, Chiller, T; Farrokhshad, K; Brummer, E; Stevens, D A
Distribution of intrinsic plasmid replicase genes and their association with carbapenem-hydrolyzing class D beta-lactamase genes in European clinical isolates of Acinetobacter baumannii.
score: 1.1677746, Antimicrobial agents and chemotherapy, 2011, Towner, Kevin J et. al.
Bile salts: natural detergents for the prevention of sexually transmitted diseases.
score: 1.1677602, Antimicrobial agents and chemotherapy, 1999, Herold, B C et. al.
Quercetin induces apoptosis of Trypanosoma brucei gambiense and decreases the proinflammatory response of human macrophages.
score: 1.1677267, Antimicrobial agents and chemotherapy, 2004, Mamani-Matsuda, Maria et. al.
Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible
score: 1.1676897, European Journal of Medicinal Chemistry, 2004, Galanski, Markus et. al.
Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2
score: 1.1676385, European Journal of Medicinal Chemistry, 2005, Agamennone, Mariangela et. al.
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT)
score: 1.1676126, Bioorganic & Medicinal Chemistry, 2012, Kozaka, Takashi et. al.
Photo-oxidation of duplex DNA with the stable trioxatriangulenium ion
score: 1.1676115, Bioorganic & Medicinal Chemistry Letters, 2003, Pothukuchy, Arti et. al.
Chiral cruciferous phytoalexins: Preparation, absolute configuration, and biological activity
score: 1.1676112, Bioorganic & Medicinal Chemistry, 2005, Monde, Kenji et. al.
Antileishmanial activity of the terpene nerolidol.
score: 1.1675948, Antimicrobial agents and chemotherapy, 2005, Arruda, Denise C et. al.
Diversity of TEM mutants in Proteus mirabilis.
score: 1.1675582, Antimicrobial agents and chemotherapy, 1999, Bonnet, R et. al.
Postantibiotic effects of daptomycin against 14 staphylococcal and pneumococcal clinical isolates.
score: 1.1675355, Antimicrobial agents and chemotherapy, 2003, Pankuch, G A; Jacobs, M R; Appelbaum, P C
N-, α-, and β-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities
score: 1.1675354, Bioorganic & Medicinal Chemistry, 2003, Tan, C.Y.K; Wainman, D; Weaver, D.F
Inactivation of the human papillomavirus-16 e6 oncoprotein by organic disulfides
score: 1.1675025, Bioorganic & Medicinal Chemistry, 2000, Beerheide, Walter et. al.
A comparative study of the hydrolysis pathways of substituted aryl phosphoramidate versus aryl thiophosphoramidate derivatives of stavudine
score: 1.1674767, European Journal of Medicinal Chemistry, 2004, Venkatachalam, T.K. et. al.
Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines — synthesis and «structure – activity» relationship
score: 1.167461, Bioorganic & Medicinal Chemistry Letters, 2012, Ivachtchenko, Alexandre V. et. al.
Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.
score: 1.1673389, Antimicrobial agents and chemotherapy, 2005, Hazbón, Manzour Hernando et. al.
Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum isolates from Gabon.
score: 1.1672617, Antimicrobial agents and chemotherapy, 2006, Kreidenweiss, Andrea et. al.
Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones
score: 1.1672315, Bioorganic & Medicinal Chemistry Letters, 2008, Aviñó, Anna et. al.
Synthesis and Structure–Activity Relationship of Dehydroxymethylepoxyquinomicin Analogues as Inhibitors of NF-κB Functions
score: 1.1671279, Bioorganic & Medicinal Chemistry, 2002, Chaicharoenpong, Chanya; Kato, Kuniki; Umezawa, Kazuo
The assembly of β-methylene-TAD, a metabolically stable analogue of the antitumor agent tad, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under mitsunobu conditions
score: 1.1671074, Bioorganic & Medicinal Chemistry Letters, 1999, Ikeda, Hisafumi; Abushanab, Elie; Marquez, Victor E.
Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells
score: 1.167085, Bioorganic & Medicinal Chemistry, 2012, Asami, Yukihiro et. al.
Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1)
score: 1.1670188, Bioorganic & Medicinal Chemistry Letters, 2012, Aboye, Teshome L. et. al.
Caged gene-inducer spatially and temporally controls gene expression and plant development in transgenic Arabidopsis plant
score: 1.1670045, Bioorganic & Medicinal Chemistry Letters, 2006, Hayashi, Ken-ichiro et. al.
Synthetic methods for the preparation of ARQ 501 (β-Lapachone) human blood metabolites
score: 1.1669994, Bioorganic & Medicinal Chemistry, 2008, Yang, Rui-Yang et. al.
Persistence of infectious herpes simplex virus type 2 in the nervous system in mice after antiviral chemotherapy.
score: 1.1669917, Antimicrobial agents and chemotherapy, 2000, Thackray, A M; Field, H J
A randomized, evaluator-blind, phase 2 study comparing the safety and efficacy of omadacycline to those of linezolid for treatment of complicated skin and skin structure infections.
score: 1.1669795, Antimicrobial agents and chemotherapy, 2012, Noel, Gary J et. al.
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.
score: 1.1668304, Nature chemical biology, 2010, Jahnke, Wolfgang et. al.
Synthesis and antibacterial evaluation of novel water-soluble organic peroxides.
score: 1.1667765, Antimicrobial agents and chemotherapy, 1998, Liu, W; Liu, X; Knaebel, D; Luck, L; Li, Y
bla(KPC) RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of Gram-negative pathogens.
score: 1.1667302, Antimicrobial agents and chemotherapy, 2011, Roth, Amanda L et. al.
Impact of prior inappropriate fluconazole dosing on isolation of fluconazole-nonsusceptible Candida species in hospitalized patients with candidemia.
score: 1.1666481, Antimicrobial agents and chemotherapy, 2012, Shah, Dhara N et. al.
Effects of amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo.
score: 1.1666422, Antimicrobial agents and chemotherapy, 2001, Worlitzsch, D et. al.
Incorporation of 4-thiothymidine into DNA by the klenow fragment and HIV-1 reverse transcriptase
score: 1.1665864, Bioorganic & Medicinal Chemistry Letters, 2000, Rao, Tata Venkata S et. al.
Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines
score: 1.1665611, Bioorganic & Medicinal Chemistry, 2007, Martínez, Alberto et. al.
S-adenosylmethionine reverses ilimaquinone's vesiculation of the Golgi apparatus
score: 1.166468, Bioorganic & Medicinal Chemistry Letters, 2001, Casaubon, Rebecca L; Snapper, Marc L
Antimicrobial activity of DC-159a, a new fluoroquinolone, against 1,149 recently collected clinical isolates.
score: 1.1664447, Antimicrobial agents and chemotherapy, 2008, Jones, Ronald N; Fritsche, Thomas R; Sader, Helio S
Probing the general time scale question of boronic acid binding with sugars in aqueous solution at physiological pH
score: 1.1664176, Bioorganic & Medicinal Chemistry, 2012, Ni, Nanting et. al.
Probing the general time scale question of boronic acid binding with sugars in aqueous solution at physiological pH
score: 1.1664176, Bioorganic & Medicinal Chemistry, 2012, Ni, Nanting et. al.
Probing the general time scale question of boronic acid binding with sugars in aqueous solution at physiological pH
score: 1.1664176, Bioorganic & Medicinal Chemistry, 2012, Ni, Nanting et. al.
Inhibition of bovine plasma amine oxidase by 1,4-diamino-2-butenes and -2-butynes
score: 1.1664152, Bioorganic & Medicinal Chemistry, 2003, Jeon, Heung-Bae et. al.
Evaluation of mismatch-binding ligands as inhibitors for Rev–RRE interaction
score: 1.1663465, Bioorganic & Medicinal Chemistry, 2006, Nakatani, Kazuhiko et. al.
Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure
score: 1.1663055, Bioorganic & Medicinal Chemistry, 2004, Velázquez, Carlos; Knaus, Edward E
In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized.
score: 1.1662611, Antimicrobial agents and chemotherapy, 2000, Bebear, C M et. al.
13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit
score: 1.1662446, Bioorganic & Medicinal Chemistry, 2005, Nishimura, Shinichi et. al.
Pharmacokinetic-pharmacodynamic comparison of amphotericin B (AMB) and two lipid-associated AMB preparations, liposomal AMB and AMB lipid complex, in murine candidiasis models.
score: 1.1660782, Antimicrobial agents and chemotherapy, 2006, Andes, D; Safdar, N; Marchillo, K; Conklin, R
RNA as scaffold for pyrene excited complexes
score: 1.1658972, Bioorganic & Medicinal Chemistry, 2008, Grünewald, Christian et. al.
Synthesis and chemical characterization of 2-methoxy- N 10-substituted acridones needed to reverse vinblastine resistance in multidrug resistant (MDR) cancer cells
score: 1.1657743, Bioorganic & Medicinal Chemistry, 2002, Krishnegowda, Gowdahalli et. al.
Morphological changes and lysis induced by beta-lactams associated with the characteristic profiles of affinities of penicillin-binding proteins in actinobacillus pleuropneumoniae.
score: 1.1657026, Antimicrobial agents and chemotherapy, 2000, Inui, T; Endo, T; Matsushita, T
Phenolics and antimicrobial activity of traditional stoned table olives ‘alcaparra’
score: 1.1655621, Bioorganic & Medicinal Chemistry, 2006, Sousa, Anabela et. al.
Quantifying the Impact of Nevirapine-Based Prophylaxis Strategies To Prevent Mother-to-Child Transmission of HIV-1: a Combined Pharmacokinetic, Pharmacodynamic, and Viral Dynamic Analysis To Predict Clinical Outcomes.
score: 1.1655533, Antimicrobial agents and chemotherapy, 2011, Frank, M et. al.
Tolerability, pharmacokinetics, and serum bactericidal activity of intravenous dalbavancin in healthy volunteers.
score: 1.1655088, Antimicrobial agents and chemotherapy, 2004, Leighton, Anton et. al.
Arylethylamine psychotropic recreational drugs: a chemical perspective
score: 1.1654821, European Journal of Medicinal Chemistry, 2002, Freeman, Sally; Alder, John F.
Mutations in cytochrome b resulting in atovaquone resistance are associated with loss of fitness in Plasmodium falciparum.
score: 1.1653842, Antimicrobial agents and chemotherapy, 2002, Peters, Jennifer M et. al.
Development of hydrocortisone succinic acid/ and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries
score: 1.1652575, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Pik-Ling et. al.
Biotin labelling of amines by polymer-assisted solution-phase synthesis
score: 1.1652295, Bioorganic & Medicinal Chemistry Letters, 2001, Golisade, Abolfasl et. al.
In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci.
score: 1.1652273, Antimicrobial agents and chemotherapy, 2004, Huang, Vanthida; Brown, William J; Rybak, Michael J
Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins.
score: 1.1651777, Antimicrobial agents and chemotherapy, 2005, Mussi, María A; Limansky, Adriana S; Viale, Alejandro M
Selective elution of target protein from affinity resins by a simple reductant with a thiol group
score: 1.1651686, Bioorganic & Medicinal Chemistry Letters, 2010, Mabuchi, Miyuki et. al.
The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry
score: 1.1649987, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Baohua et. al.
The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry
score: 1.1649987, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Baohua et. al.
Immunostimulatory activities of monoglycosylated α- d-pyranosylceramides
score: 1.1649864, Bioorganic & Medicinal Chemistry, 1997, Uchimura, Akira et. al.
Emergence of OXA-48-producing Escherichia coli clone ST38 in France.
score: 1.1649342, Antimicrobial agents and chemotherapy, 2011, Poirel, Laurent et. al.
The high affinity melatonin binding site probed with conformationally restricted ligands—I. Pharmacophore and minireceptor models
score: 1.1648976, Bioorganic & Medicinal Chemistry, 1996, Jansen, Johanna M. et. al.
VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus.
score: 1.1648874, Antimicrobial agents and chemotherapy, 2006, Yin, Shaohui; Daum, Robert S; Boyle-Vavra, Susan
Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes.
score: 1.1648661, Antimicrobial agents and chemotherapy, 2003, Park, Ji-Young; Kim, Kyoung-Ah; Kim, Su-Lyun
Heterocycle-functional gramine analogues: Solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation
score: 1.1647736, European Journal of Medicinal Chemistry, 2012, Ke, Shaoyong et. al.
Heterocycle-functional gramine analogues: Solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation
score: 1.1647736, European Journal of Medicinal Chemistry, 2012, Ke, Shaoyong et. al.
Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation
score: 1.1646763, Bioorganic & Medicinal Chemistry, 2001, Tamamura, Hirokazu et. al.
Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL
score: 1.1646718, Bioorganic & Medicinal Chemistry Letters, 2009, Orzáez, Mar et. al.
Synthesis and anti-HIV activity of trivalent CD4-mimetic miniproteins
score: 1.1646625, Bioorganic & Medicinal Chemistry, 2007, Li, Hengguang et. al.
Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus.
score: 1.1646496, Antimicrobial agents and chemotherapy, 2002, Zhao, Wei-Hua et. al.
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense
score: 1.1646011, Bioorganic & Medicinal Chemistry Letters, 2012, Vullo, Daniela et. al.
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
score: 1.1645917, Antimicrobial agents and chemotherapy, 2006, Hazbón, Manzour Hernando et. al.
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres via epoxyalcohols derived from α-amino acids
score: 1.1645825, Bioorganic & Medicinal Chemistry Letters, 1999, Benedetti, Fabio et. al.
Prodrug Mono therapy: synthesis and biological evaluation of an etoposide glucuronide-prodrug
score: 1.164541, Bioorganic & Medicinal Chemistry, 2003, Schmidt, Frédéric; Monneret, Claude
Topological modelling of analgesia
score: 1.1644817, Bioorganic & Medicinal Chemistry, 2003, Mathur, K.C; Gupta, Sunita; Khadikar, P.V
In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains.
score: 1.1644314, Antimicrobial agents and chemotherapy, 2004, Higgins, Paul G et. al.
Selectivity in DNA interstrand-stacking
score: 1.1641937, Bioorganic & Medicinal Chemistry Letters, 2006, Langenegger, Simon M.; Häner, Robert
Characterization of CIA-1, an Ambler Class A Extended-Spectrum β-Lactamase from Chryseobacterium indologenes.
score: 1.1641326, Antimicrobial agents and chemotherapy, 2012, Matsumoto, Takehisa et. al.
Novel expansions of the gene encoding dihydropteroate synthase in trimethoprim-sulfamethoxazole-resistant Streptococcus pneumoniae.
score: 1.1640907, Antimicrobial agents and chemotherapy, 1999, Padayachee, T; Klugman, K P
In vitro activity of a novel antimicrobial agent, TG44, for treatment of Helicobacter pylori infection.
score: 1.164061, Antimicrobial agents and chemotherapy, 2006, Kamoda, Osamu et. al.
Antiviral activity of a selective ribonucleotide reductase inhibitor against acyclovir-resistant herpes simplex virus type 1 in vivo.
score: 1.16403, Antimicrobial agents and chemotherapy, 1998, Duan, J et. al.
The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe.
score: 1.1638492, Antimicrobial agents and chemotherapy, 2004, Schweingruber, M Ernst
Phosphate transfer from inositol pyrophosphates InsP 5PP and InsP 4(PP) 2: A semi-empirical investigation
score: 1.163848, Bioorganic & Medicinal Chemistry Letters, 2007, Hand, Christine E.; Honek, John F.
Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria
score: 1.1637722, Bioorganic & Medicinal Chemistry, 1998, Srivastava, Pratima et. al.
Spontaneous mutations that confer antibiotic resistance in Helicobacter pylori.
score: 1.1637603, Antimicrobial agents and chemotherapy, 2001, Wang, G; Wilson, T J; Jiang, Q; Taylor, D E
Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections.
score: 1.1635424, Antimicrobial agents and chemotherapy, 2011, Ghannoum, M A; Isham, N; Jacobs, M R
Clinafloxacin versus piperacillin-tazobactam in treatment of patients with severe skin and soft tissue infections.
score: 1.1635254, Antimicrobial agents and chemotherapy, 2001, Siami, G et. al.
In vitro activity of linezolid against Clostridium difficile.
score: 1.1635029, Antimicrobial agents and chemotherapy, 2002, Peláez, T et. al.
17β-Estradiol nitration by peroxidase/H 2O 2/NO 2 −: a chemical assessment
score: 1.163498, Bioorganic & Medicinal Chemistry, 2004, Pezzella, Alessandro et. al.
Synthesis of oligodeoxynucleotides containing a single diastereoisomer of α-( N 2-2′-deoxyguanosinyl)- N-desmethyltamoxifen
score: 1.1634897, Bioorganic & Medicinal Chemistry Letters, 2004, Santosh Laxmi, Y.R et. al.
Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients.
score: 1.1634772, Antimicrobial agents and chemotherapy, 2010, Chou, Monidarin et. al.
What constitutes an extended-spectrum beta-lactamase?
score: 1.1634292, Antimicrobial agents and chemotherapy, 2002, Smith, C Jeffrey
Validate antibacterial mode and find main bioactive components of traditional Chinese medicine Aquilegia oxysepala
score: 1.1632867, Bioorganic & Medicinal Chemistry Letters, 2007, Yu, Yan; Yi, Zhi-biao; Liang, Yi-Zeng
High-level expression of ampC beta-lactamase due to insertion of nucleotides between -10 and -35 promoter sequences in Escherichia coli clinical isolates: cases not responsive to extended-spectrum-cephalosporin treatment.
score: 1.1632711, Antimicrobial agents and chemotherapy, 2003, Siu, L K et. al.
Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes.
score: 1.1632275, Antimicrobial agents and chemotherapy, 1999, Roberts, M C et. al.
A one-pot multistep approach to α-azido-phosphonate and phosphonothioate diesters: key intermediates in the synthesis of haptens for the generation of antibody ligases
score: 1.1632255, Bioorganic & Medicinal Chemistry Letters, 2000, Harwig, Curtis W. et. al.
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase
score: 1.1631942, Bioorganic & Medicinal Chemistry, 2006, Hazai, Eszter et. al.
Prevalence of clinical isolates of Escherichia coli producing inhibitor-resistant beta-lactamases at a University Hospital in Barcelona, Spain, over a 3-year period.
score: 1.1631697, Antimicrobial agents and chemotherapy, 2002, Miró, Elisenda et. al.
A tetra( l-lysine)-grafted poly(organophosphazene) for gene delivery
score: 1.1631063, Bioorganic & Medicinal Chemistry Letters, 2007, Jun, Yong Joo et. al.
Noninvasive optical imaging method to evaluate postantibiotic effects on biofilm infection in vivo.
score: 1.1630404, Antimicrobial agents and chemotherapy, 2004, Kadurugamuwa, Jagath L et. al.
Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel l-FucNAc and d-FucNAc synthons and immunochemical evaluation
score: 1.1630227, Bioorganic & Medicinal Chemistry, 2012, Danieli, Elisa et. al.
Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel l-FucNAc and d-FucNAc synthons and immunochemical evaluation
score: 1.1630227, Bioorganic & Medicinal Chemistry, 2012, Danieli, Elisa et. al.
Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function.
score: 1.1629473, Antimicrobial agents and chemotherapy, 2005, Sakoulas, George et. al.
Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents
score: 1.1629366, European Journal of Medicinal Chemistry, 2006, Lee, Ki Yong et. al.
Competition of various beta-lactam antibiotics for the major penicillin-binding proteins of Helicobacter pylori: antibacterial activity and effects on bacterial morphology.
score: 1.1629315, Antimicrobial agents and chemotherapy, 1999, DeLoney, C R; Schiller, N L
Altering the proclivity towards daptomycin resistance in methicillin-resistant Staphylococcus aureus using combinations with other antibiotics.
score: 1.1628009, Antimicrobial agents and chemotherapy, 2012, Berti, Andrew D et. al.
RNA-hydrolyzing activity of human serum albumin and its recombinant analogue
score: 1.1627143, Bioorganic & Medicinal Chemistry Letters, 2010, Gerasimova, Yulia V. et. al.
Potential therapeutic role of cationic peptides in three experimental models of septic shock.
score: 1.1625761, Antimicrobial agents and chemotherapy, 2002, Giacometti, Andrea et. al.
Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
score: 1.1625565, Antimicrobial agents and chemotherapy, 2008, Qin, Xuan et. al.
Identification of a novel genomic island conferring resistance to multiple aminoglycoside antibiotics in Campylobacter coli.
score: 1.1624584, Antimicrobial agents and chemotherapy, 2012, Qin, Shangshang et. al.
New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.
score: 1.1623963, Antimicrobial agents and chemotherapy, 2005, Suling, W J; Seitz, L E; Reynolds, R C; Barrow, W W
Theoretical calculations of a model of NOS indazole inhibitors: Interaction of aromatic compounds with Zn-porphyrins
score: 1.1623489, Bioorganic & Medicinal Chemistry, 2009, Elguero, José et. al.
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors
score: 1.1623455, Bioorganic & Medicinal Chemistry Letters, 2012, Gealageas, Ronan et. al.
QSAR study on carbonic anhydrase inhibitors: water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intra ocular pressure lowering properties—a molecular connectivity approach
score: 1.1622928, European Journal of Medicinal Chemistry, 2005, Agrawal, Vijay K. et. al.
Pyrazinamide susceptibility testing in Mycobacterium tuberculosis: a systematic review with meta-analyses.
score: 1.1622589, Antimicrobial agents and chemotherapy, 2011, Chang, Kwok Chiu; Yew, Wing Wai; Zhang, Ying
In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.
score: 1.1621811, Antimicrobial agents and chemotherapy, 2012, Marschall, Manfred et. al.
Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs.
score: 1.1621596, Antimicrobial agents and chemotherapy, 2012, Smee, Donald F et. al.
Cleavage and protection of locked nucleic acid–modified DNA by restriction endonucleases
score: 1.1620797, Bioorganic & Medicinal Chemistry Letters, 2012, Crouzier, Lucile et. al.
In vitro interaction of flucytosine combined with amphotericin B or fluconazole against thirty-five yeast isolates determined by both the fractional inhibitory concentration index and the response surface approach.
score: 1.1620755, Antimicrobial agents and chemotherapy, 2002, Te Dorsthorst, D T A et. al.
Activity of gatifloxacin in an in vitro pharmacokinetic-pharmacodynamic model against Staphylococcus aureus strains either susceptible to ciprofloxacin or exhibiting various levels and mechanisms of ciprofloxacin resistance.
score: 1.1620585, Antimicrobial agents and chemotherapy, 2006, Ba, Boubakar B et. al.
Activity of picolinic acid in combination with the antiprotozoal drug quinacrine against Mycobacterium avium complex.
score: 1.1620487, Antimicrobial agents and chemotherapy, 2006, Shimizu, Toshiaki; Tomioka, Haruaki
8,9-Methylenedioxybenzo[ i]phenanthridines
score: 1.1620445, Bioorganic & Medicinal Chemistry, 2003, Li, Dajie et. al.
Consequences of noncompliance for therapy efficacy and emergence of resistance in murine tuberculosis caused by the Beijing genotype of Mycobacterium tuberculosis.
score: 1.1620375, Antimicrobial agents and chemotherapy, 2012, de Steenwinkel, Jurriaan E M et. al.
Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation
score: 1.1620374, Bioorganic & Medicinal Chemistry, 2012, Tanaka, Hiroshi et. al.
Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.
score: 1.1619589, Antimicrobial agents and chemotherapy, 2004, Huang, Li; Yuan, Xiong; Aiken, Christopher; Chen, Chin Ho
Facile synthesis of [ 11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase
score: 1.1618854, Bioorganic & Medicinal Chemistry Letters, 2003, Zheng, Qi-Huang et. al.
Limitations of cytomegalovirus testing.
score: 1.1618389, Antimicrobial agents and chemotherapy, 1999, Harmenberg, J; Brytting, M
Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: Synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60
score: 1.1618265, European Journal of Medicinal Chemistry, 2009, Angelusiu, Madalina Veronica et. al.
Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA—II. Modification of pyrrolidine ring at P1′ proline
score: 1.161725, Bioorganic & Medicinal Chemistry, 1996, Komai, Tomoaki et. al.
Efficacy of orally delivered cochleates containing amphotericin B in a murine model of aspergillosis.
score: 1.1616572, Antimicrobial agents and chemotherapy, 2002, Delmas, G et. al.
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.
score: 1.1616217, Bioorganic & Medicinal Chemistry, 2009, Dastmalchi, Keyvan et. al.
Activity of DX-619 compared to other agents against viridans group streptococci, Streptococcus bovis, and Cardiobacterium hominis.
score: 1.1615854, Antimicrobial agents and chemotherapy, 2006, Kosowska-Shick, Klaudia et. al.
Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria.
score: 1.1615413, Antimicrobial agents and chemotherapy, 2000, Newton, P et. al.
Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.
score: 1.1615105, Antimicrobial agents and chemotherapy, 2009, Akkarawongsa, Radeekorn et. al.
In vitro and in vivo antibacterial activities of DC-159a, a new fluoroquinolone.
score: 1.1613578, Antimicrobial agents and chemotherapy, 2008, Hoshino, Kazuki et. al.
Carbohydrate recognition by pentadecapeptide ligands for a series of sialylated oligosaccharides
score: 1.1613066, Bioorganic & Medicinal Chemistry, 2012, Matsubara, Teruhiko; Onishi, Ai; Sato, Toshinori
Carbohydrate recognition by pentadecapeptide ligands for a series of sialylated oligosaccharides
score: 1.1613066, Bioorganic & Medicinal Chemistry, 2012, Matsubara, Teruhiko; Onishi, Ai; Sato, Toshinori
Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.
score: 1.1611934, Antimicrobial agents and chemotherapy, 2006, Afonso, A et. al.
Synthesis and SAR of 3- and 4-substituted quinolin-2-ones: discovery of mixed 5-HT 1B/5-HT 2A receptor antagonists
score: 1.1611867, Bioorganic & Medicinal Chemistry, 2001, McCort, Gary et. al.
Molecular epidemiological analysis of Escherichia coli sequence type ST131 (O25:H4) and blaCTX-M-15 among extended-spectrum-β-lactamase-producing E. coli from the United States, 2000 to 2009.
score: 1.1611473, Antimicrobial agents and chemotherapy, 2012, Johnson, James R et. al.
Design and biological evaluation of phenyl-substituted analogs of β-phenylethylidenehydrazine
score: 1.1610858, Bioorganic & Medicinal Chemistry, 2005, Sowa, Bernard et. al.
Contribution of Selected Gene Mutations to Resistance in Clinical Isolates of Vancomycin-Intermediate Staphylococcus aureus.
score: 1.1607659, Antimicrobial agents and chemotherapy, 2012, Hafer, Cory et. al.
Synthesis and preliminary pharmacological evaluation of 5-Hydroxy- and 5,6-dihydroxy-1,2,3,7,12,12a-hexahydrobenzo[5,6]cyclohepta[1,2,3- ij]isoquinoline derivatives as dopamine receptor ligands
score: 1.1606901, Bioorganic & Medicinal Chemistry, 2001, Cingolani, Gian Mario et. al.
HP-Lattice QSAR for dynein proteins: Experimental proteomics (2D-electrophoresis, mass spectrometry) and theoretic study of a Leishmania infantum sequence
score: 1.1605326, Bioorganic & Medicinal Chemistry, 2008, Dea-Ayuela, María Auxiliadora et. al.
Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum
score: 1.1605146, Bioorganic & Medicinal Chemistry, 2012, Dinio, Theresa et. al.
Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum
score: 1.1605146, Bioorganic & Medicinal Chemistry, 2012, Dinio, Theresa et. al.
Compensatory adaptation to the loss of biological fitness associated with acquisition of fusidic acid resistance in Staphylococcus aureus.
score: 1.1605122, Antimicrobial agents and chemotherapy, 2005, Besier, Silke et. al.
Antibiotic-induced release of lipoteichoic acid and peptidoglycan from Staphylococcus aureus: quantitative measurements and biological reactivities.
score: 1.1605119, Antimicrobial agents and chemotherapy, 1998, van Langevelde, P et. al.
An effective chromatographic separation of chicken red blood cell coproporphyrinogen oxidase and uroporphyrinogen decarboxylase, two enzymes in heme biosynthesis
score: 1.1604171, Bioorganic & Medicinal Chemistry Letters, 2004, Jones, Marjorie A. et. al.
Conformation stability and organization of mefloquine molecules in different environments
score: 1.1604091, Bioorganic & Medicinal Chemistry Letters, 2006, Skórska, Agnieszka; Śliwiński, Jan; Oleksyn, Barbara J.
The structure of Rimonabant in the solid state and in solution: An experimental and theoretical study
score: 1.1604032, European Journal of Medicinal Chemistry, 2009, Alkorta, Ibon et. al.
Resuscitation-promoting factors are required for β-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.
score: 1.1601723, Antimicrobial agents and chemotherapy, 2012, Wivagg, Carl N; Hung, Deborah T
Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators
score: 1.1601518, Bioorganic & Medicinal Chemistry, 2006, Singh, Palwinder; Paul, Kamaldeep; Holzer, Wolfgang
Evaluation of voriconazole pharmacodynamics using time-kill methodology.
score: 1.1600907, Antimicrobial agents and chemotherapy, 2000, Klepser, M E et. al.
Knockdown of USP18 increases alpha 2a interferon signaling and induction of interferon-stimulating genes but does not increase antiviral activity in Huh7 cells.
score: 1.1599349, Antimicrobial agents and chemotherapy, 2011, Murray, E J et. al.
Synthesis, gene-silencing activity and nuclease resistance of 3′–3′-linked double short hairpin RNA
score: 1.1598862, Bioorganic & Medicinal Chemistry, 2010, Masuda, Hirofumi et. al.
Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production.
score: 1.1598711, Antimicrobial agents and chemotherapy, 2011, Jump, Robin L P et. al.
Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors
score: 1.1598161, Bioorganic & Medicinal Chemistry, 2004, Wan, Sheng Biao; Chen, Di; Ping Dou, Q.; Hang Chan, Tak
Effect of flavonoids on the Aβ(25-35)-phospholipid bilayers interaction
score: 1.1597532, European Journal of Medicinal Chemistry, 2010, Tedeschi, Annamaria et. al.
A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter
score: 1.1597338, Bioorganic & Medicinal Chemistry Letters, 2013, Zhang, Peng et. al.
Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons
score: 1.1596699, Bioorganic & Medicinal Chemistry, 1996, Kim, Jung Sun et. al.
Synthesis of fluorescent substrates for protein tyrosine phosphatase assays
score: 1.1596241, Bioorganic & Medicinal Chemistry Letters, 1998, Watanabe, Takumi et. al.
Novel antioxidant agents deriving from molecular combinations of vitamins C and E analogues: 3,4-dihydroxy-5( R)-[2( R,S)-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2( R,S)-yl-methyl)-[1,3]dioxolan-4( S)-yl]-5 H-furan-2-one and 3- O-octadecyl derivatives
score: 1.1594262, Bioorganic & Medicinal Chemistry, 2000, Manfredini, Stefano et. al.
Discovery, structure–activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity
score: 1.1593368, Bioorganic & Medicinal Chemistry, 2006, Yamamoto, Takashi et. al.
Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis.
score: 1.1593256, Antimicrobial agents and chemotherapy, 2003, Materon, Isabel C et. al.
Dda helicase unwinds a DNA–PNA chimeric substrate: Evidence for an inchworm mechanism
score: 1.1592785, Bioorganic & Medicinal Chemistry Letters, 2006, Spurling, Travis L.; Eoff, Robert L.; Raney, Kevin D.
Evaluation of clinical outcomes in patients with bloodstream infections due to Gram-negative bacteria according to carbapenem MIC stratification.
score: 1.1592062, Antimicrobial agents and chemotherapy, 2012, Esterly, John S et. al.
Novel Mannich ketones of oxazolidinones as antibacterial agents
score: 1.1591447, European Journal of Medicinal Chemistry, 2004, Srivastava, Brijesh Kumar et. al.
Pharmacokinetics of oritavancin in plasma and skin blister fluid following administration of a 200-milligram dose for 3 days or a single 800-milligram dose.
score: 1.1590201, Antimicrobial agents and chemotherapy, 2005, Fetterly, Gerald J et. al.
Efficacy of ceftaroline fosamil in a staphylococcal murine pneumonia model.
score: 1.1589908, Antimicrobial agents and chemotherapy, 2012, Bhalodi, Amira A et. al.
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters
score: 1.1589856, Bioorganic & Medicinal Chemistry, 2005, Nakamura, Seikou et. al.
DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences
score: 1.1589846, Bioorganic & Medicinal Chemistry, 2012, Viswesh, Velliyur et. al.
Comparative docking studies of labdane-type diterpenes with forskolin at the active site of adenylyl cyclase
score: 1.1589844, Bioorganic & Medicinal Chemistry, 2008, Koukoulitsa, Catherine et. al.
Perylene diimides with different side chains are selective in inducing different G-Quadruplex DNA structures and in inhibiting telomerase
score: 1.1589614, Bioorganic & Medicinal Chemistry Letters, 2002, Rossetti, Luigi et. al.
Synthesis and pharmacological evaluation of imidazoline sites I 1 and I 2 selective ligands
score: 1.158942, Bioorganic & Medicinal Chemistry, 2001, Anastassiadou, Maria et. al.
Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene.
score: 1.1589019, Antimicrobial agents and chemotherapy, 2000, Margolis, P S et. al.
Let’s not forget tautomers
score: 1.1588961, Journal of Computer-Aided Molecular Design, 2009, Martin, Yvonne Connolly
Synthesis and biological evaluation of pentacyclo[5.4.0.0 2,6.0 3,10.0 5,9]undecane derivatives as potential therapeutic agents in Parkinson's disease
score: 1.1588698, Bioorganic & Medicinal Chemistry, 2004, Geldenhuys, Werner J et. al.
MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats
score: 1.1588689, Bioorganic & Medicinal Chemistry Letters, 2012, Bell, Ian M. et. al.
MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats
score: 1.1588689, Bioorganic & Medicinal Chemistry Letters, 2012, Bell, Ian M. et. al.
The use of dioxygen by HIF prolyl hydroxylase (PHD1)
score: 1.1588517, Bioorganic & Medicinal Chemistry Letters, 2002, McNeill, Luke A et. al.
Effect of coordinated ligands on antiproliferative activity and DNA cleavage property of three mononuclear Cu(II)-terpyridine complexes
score: 1.1587688, European Journal of Medicinal Chemistry, 2012, Manikandamathavan, Verasuntharam M. et. al.
Effect of coordinated ligands on antiproliferative activity and DNA cleavage property of three mononuclear Cu(II)-terpyridine complexes
score: 1.1587688, European Journal of Medicinal Chemistry, 2012, Manikandamathavan, Verasuntharam M. et. al.
Effect of sodium fluoride, ampicillin, and chlorhexidine on Streptococcus mutans biofilm detachment.
score: 1.1587426, Antimicrobial agents and chemotherapy, 2012, Liu, Jia; Ling, Jun-Qi; Zhang, Kai; Huo, Li-Jun; Ning, Yang
Synthesis of chiral fluorine-tagged reference standards for the 19F NMR-based stereochemical analysis of sulfoxides at trace analytical levels
score: 1.1587365, Bioorganic & Medicinal Chemistry Letters, 2009, Tremblay, Amy E. et. al.
Molecular cloning and characterization of copper amine oxidase from Huperzia serrata
score: 1.1586916, Bioorganic & Medicinal Chemistry Letters, 2012, Sun, Jieyin et. al.
Real-time fluorescence monitoring of GSK3β-catalyzed phosphoryation by use of a BODIPY-based Zn(II)–Dpa chemosensor
score: 1.1586652, Bioorganic & Medicinal Chemistry Letters, 2009, Sakamoto, Takashi et. al.
Meningeal inflammation increases artemether concentrations in cerebrospinal fluid in Papua New Guinean children treated with intramuscular artemether.
score: 1.1585677, Antimicrobial agents and chemotherapy, 2011, Manning, Laurens et. al.
Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis.
score: 1.1585373, Antimicrobial agents and chemotherapy, 2006, Reed, Caitlin et. al.
Solution NMR analysis of the binding mechanism of DIVS6 model peptides of voltage-gated sodium channels and the lipid soluble alkaloid veratridine
score: 1.1584373, Bioorganic & Medicinal Chemistry, 2012, Yoshinaka-Niitsu, Ai et. al.
Dual roles of FmtA in Staphylococcus aureus cell wall biosynthesis and autolysis.
score: 1.1584349, Antimicrobial agents and chemotherapy, 2012, Qamar, Aneela; Golemi-Kotra, Dasantila
Fungicide chinomethionate as a new family of photoinducible DNA-cleaving agents
score: 1.1584078, Bioorganic & Medicinal Chemistry Letters, 2003, Qi, Jianying; Li, Tianhu; Chan, Albert S.C
Synthesis and biological evaluation of 2-methoxy- and 2-Methylthio-6-[(2′-alkylamino)ethyl]-4(3 H)-pyrimidinones with anti-rubella virus activity
score: 1.1583506, Bioorganic & Medicinal Chemistry, 1999, Botta, Maurizio et. al.
New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron.
score: 1.1583262, Antimicrobial agents and chemotherapy, 1998, Adrian, P V; DU Plessis, M; Klugman, K P; Amyes, S G
Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species.
score: 1.1582971, Antimicrobial agents and chemotherapy, 2012, Lackner, Michaela et. al.
Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis.
score: 1.158259, Antimicrobial agents and chemotherapy, 2006, Grivea, Ioanna N et. al.
Surface and biocidal activity of some synthesized metallo azobenzene isothiouronium salts
score: 1.1581608, Bioorganic & Medicinal Chemistry, 2006, Badawi, A.M.; Azzam, E.M.S.; Morsy, S.M.I.
The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates
score: 1.158152, Bioorganic & Medicinal Chemistry, 2012, Santner, Tobias et. al.
Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group.
score: 1.1581408, Antimicrobial agents and chemotherapy, 2000, Hughes, W T et. al.
A new antioxidative vitamin B 6 analogue modulates pathophysiological cell proliferation and damage
score: 1.1580768, Bioorganic & Medicinal Chemistry, 1999, Kesel, Andreas J et. al.
Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display
score: 1.1580761, Bioorganic & Medicinal Chemistry Letters, 2001, Chin, Jason W et. al.
Evaluation of screening methods to detect plasmid-mediated AmpC in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.
score: 1.1580501, Antimicrobial agents and chemotherapy, 2009, Tan, Thean Yen et. al.
Hydrolytic cleavage of DNA by quercetin zinc(II) complex
score: 1.1580279, Bioorganic & Medicinal Chemistry Letters, 2007, Jun, Tan; Bochu, Wang; Liancai, Zhu
Solid-phase synthesis and biochemical evaluation of conformationally constrained analogues of deglycobleomycin A 5
score: 1.1579877, Bioorganic & Medicinal Chemistry, 2003, Cagir, Ali; Tao, Zhi-Fu; Sucheck, Steven J; Hecht, Sidney M
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.
score: 1.157958, Antimicrobial agents and chemotherapy, 2005, Faundez, Mario et. al.
Cluster analysis of the DrugBank chemical space using molecular quantum numbers
score: 1.1578768, Bioorganic & Medicinal Chemistry, 2012, Awale, Mahendra; Reymond, Jean-Louis
Immobilization of self-quenched DNA hairpin probe with a heterobifunctional reagent on a glass surface for sensitive detection of oligonucleotides
score: 1.1578577, Bioorganic & Medicinal Chemistry, 2009, Misra, Arvind; Shahid, Mohammad
Ganglioside binding pattern of CD33-related siglecs
score: 1.157789, Bioorganic & Medicinal Chemistry Letters, 2003, Rapoport, Eugenia et. al.
Syntheses of ( Z)- and ( E)-4-amino-2-(trifluoromethyl)-2-butenoic acid and Their inactivation of γ-aminobutyric acid aminotransferase
score: 1.1576663, Bioorganic & Medicinal Chemistry, 1999, Johnson, Theodore R.; Silverman, Richard B.
Synthesis of 2-amino-6-(4-[ 11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers
score: 1.1573896, Bioorganic & Medicinal Chemistry, 2005, Wang, Ji-Quan et. al.
Characterization of OXA-181, a carbapenem-hydrolyzing class D beta-lactamase from Klebsiella pneumoniae.
score: 1.1573595, Antimicrobial agents and chemotherapy, 2011, Potron, Anaïs et. al.
Design and development of a fluorescent probe for monitoring hydrogen peroxide using photoinduced electron transfer
score: 1.1572901, Bioorganic & Medicinal Chemistry, 2005, Soh, Nobuaki et. al.
Plasma and intracellular tenofovir pharmacokinetics in the neonate (ANRS 12109 trial, step 2).
score: 1.1572758, Antimicrobial agents and chemotherapy, 2011, Hirt, Déborah et. al.
Mechanism of fluconazole resistance in Candida krusei.
score: 1.1572718, Antimicrobial agents and chemotherapy, 1998, Orozco, A S et. al.
Chemosensitization of Plasmodium falciparum by probenecid in vitro.
score: 1.1572246, Antimicrobial agents and chemotherapy, 2003, Nzila, Alexis et. al.
Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing.
score: 1.1572064, Antimicrobial agents and chemotherapy, 2001, Drusano, G L et. al.
Bactericidal activity of gentamicin against Enterococcus faecalis in vitro and in vivo.
score: 1.1569214, Antimicrobial agents and chemotherapy, 2000, Lefort, A et. al.
N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin
score: 1.1569104, Bioorganic & Medicinal Chemistry Letters, 2012, Singh, Gurmit et. al.
Studies of interactions between uracil-based hybrid molecules and P-glycoprotein—Search for multidrug resistance modulators
score: 1.1569016, Bioorganic & Medicinal Chemistry, 2006, Singh, Palwinder; Paul, Kamaldeep
Synthesis and antimycobacterial activity of new S-alkylisothiosemicarbazone derivatives
score: 1.1568901, Bioorganic & Medicinal Chemistry, 2002, Cocco, Maria Teresa et. al.
Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals.
score: 1.1568791, Antimicrobial agents and chemotherapy, 2004, Gaziano, Roberta et. al.
Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
score: 1.1568539, Antimicrobial agents and chemotherapy, 2000, Goldstein, E J et. al.
Famciclovir and valaciclovir differ in the prevention of herpes simplex virus type 1 latency in mice: a quantitative study.
score: 1.1568525, Antimicrobial agents and chemotherapy, 1998, Thackray, A M; Field, H J
Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea.
score: 1.1568123, Antimicrobial agents and chemotherapy, 2005, Lee, Kyungwon et. al.
Derivatives of a vancomycin-resistant Staphylococcus aureus strain isolated at Hershey Medical Center.
score: 1.15678, Antimicrobial agents and chemotherapy, 2004, Bozdogan, Bülent et. al.
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections
score: 1.156722, Bioorganic & Medicinal Chemistry Letters, 2012, Mitton-Fry, Mark J. et. al.
QSAR modeling of the inhibition of Glycogen Synthase Kinase-3
score: 1.1567201, Bioorganic & Medicinal Chemistry, 2006, Katritzky, Alan R. et. al.
Synthesis of ruthenium(II) complexes and characterization of their cytotoxicity in vitro, apoptosis, DNA-binding and antioxidant activity
score: 1.1565725, European Journal of Medicinal Chemistry, 2010, Liu, Yun-Jun et. al.
Synthesis of ruthenium(II) complexes and characterization of their cytotoxicity in vitro, apoptosis, DNA-binding and antioxidant activity
score: 1.1565725, European Journal of Medicinal Chemistry, 2010, Liu, Yun-Jun et. al.
Identification of Hopanoid Biosynthesis Genes Involved in Polymyxin Resistance in Burkholderia multivorans.
score: 1.1565214, Antimicrobial agents and chemotherapy, 2012, Malott, Rebecca J et. al.
Spectroscopic characterization of the inclusion complexes of luteolin with native and derivatized β-cyclodextrin
score: 1.1565107, Bioorganic & Medicinal Chemistry, 2010, Jullian, Carolina et. al.
Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI
score: 1.1564857, Bioorganic & Medicinal Chemistry Letters, 2010, Sideratou, Zili et. al.
β-Lactams Increase the Antibacterial Activity of Daptomycin against Clinical Methicillin-Resistant Staphylococcus aureus Strains and Prevent Selection of Daptomycin-Resistant Derivatives.
score: 1.1564795, Antimicrobial agents and chemotherapy, 2012, Mehta, Shrenik et. al.
Tetrahedron Young Investigator Award 2009: Carlos F. Barbas, III
score: 1.1564005, Bioorganic & Medicinal Chemistry Letters, 2009,
Complex genetic structures with repeated elements, a sul-type class 1 integron, and the blaVEB extended-spectrum beta-lactamase gene.
score: 1.1563812, Antimicrobial agents and chemotherapy, 2006, Naas, Thierry et. al.
A DFT-based QSARs study of protoporphyrinogen oxidase inhibitors: phenyl triazolinones
score: 1.1563125, Bioorganic & Medicinal Chemistry, 2004, Zhang, Li; Wan, Jian; Yang, Guangfu
Synthesis, characterization, and biocide properties of semicarbazide–formaldehyde resin and its polymer metal complexes
score: 1.1562812, European Journal of Medicinal Chemistry, 2010, Nishat, Nahid et. al.
Mechanism-based pharmacodynamic models of fluoroquinolone resistance in Staphylococcus aureus.
score: 1.1562541, Antimicrobial agents and chemotherapy, 2006, Chung, Philip et. al.
A novel agent effective against Clostridium difficile infection.
score: 1.1560675, Antimicrobial agents and chemotherapy, 2012, Dvoskin, Sofya et. al.
Characterisation and biodistribution of two neutral 99mTc(CO) 3 complexes with a tridentate ligand
score: 1.155938, Bioorganic & Medicinal Chemistry Letters, 2005, Rattat, Dirk et. al.
Spontaneous mutations in the Plasmodium falciparum sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among geographically widespread parasite populations unexposed to artemisinin-based combination therapies.
score: 1.1558888, Antimicrobial agents and chemotherapy, 2011, Tanabe, Kazuyuki et. al.
RNA interference by 2′,5′-linked nucleic acid duplexes in mammalian cells
score: 1.1558663, Bioorganic & Medicinal Chemistry Letters, 2006, Prakash, Thazha P. et. al.
Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition
score: 1.155795, Bioorganic & Medicinal Chemistry, 2000, Mangla, Anil T; Nes, W.David
Chromosomal system for studying AmpC-mediated beta-lactam resistance mutation in Escherichia coli.
score: 1.1557164, Antimicrobial agents and chemotherapy, 2002, Petrosino, Joseph F et. al.
A whole organism screen identifies novel regulators of fat storage
score: 1.1557156, Nature chemical biology, 2011, Lemieux, George A. et. al.
Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.
score: 1.1556363, Antimicrobial agents and chemotherapy, 2009, Woolhiser, Lisa K et. al.
Synthesis and insecticidal activity of novel dihydropyrrole derivatives with N-Sulfanyl, sulfinyl, and sulfonyl moieties
score: 1.1555871, Bioorganic & Medicinal Chemistry, 2003, Ito, Mitsuru et. al.
Comparative evaluation of the VITEK 2, disk diffusion, etest, broth microdilution, and agar dilution susceptibility testing methods for colistin in clinical isolates, including heteroresistant Enterobacter cloacae and Acinetobacter baumannii strains.
score: 1.1555819, Antimicrobial agents and chemotherapy, 2007, Lo-Ten-Foe, Jerome R et. al.
In vitro and In vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β- d-pentagalloylglucose
score: 1.1555598, Bioorganic & Medicinal Chemistry Letters, 2001, Feldman, Ken S. et. al.
A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer.
score: 1.1555145, Antimicrobial agents and chemotherapy, 1998, Boyer, P L; Gao, H Q; Hughes, S H
Halovirs A–E, new antiviral agents from a marine-Derived fungus of the genus Scytalidium
score: 1.1554376, Bioorganic & Medicinal Chemistry, 2003, Rowley, David C et. al.
Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.
score: 1.155437, Antimicrobial agents and chemotherapy, 2001, Kalfa, V C et. al.
Synthesis, antitumor and anti-HIV activities of benzodithiazine-dioxides
score: 1.1553837, Bioorganic & Medicinal Chemistry, 2006, Brzozowski, Zdziasław; Sączewski, Franciszek; Neamati, Nouri
In vitro activities of trovafloxacin against 557 strains of anaerobic bacteria.
score: 1.1553534, Antimicrobial agents and chemotherapy, 1996, Wexler, H M; Molitoris, E; Molitoris, D; Finegold, S M
Y-688, a new quinolone active against quinolone-resistant Staphylococcus aureus: lack of in vivo efficacy in experimental endocarditis.
score: 1.1552789, Antimicrobial agents and chemotherapy, 1998, Entenza, J M; Marchetti, O; Glauser, M P; Moreillon, P
Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries
score: 1.1552404, Bioorganic & Medicinal Chemistry Letters, 2007, Krzysiak, Amanda J. et. al.
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.
score: 1.1551971, Antimicrobial agents and chemotherapy, 2003, Hayden, Frederick G et. al.
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B
score: 1.154857, European Journal of Medicinal Chemistry, 2012, Balaydın, Halis T. et. al.
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B
score: 1.154857, European Journal of Medicinal Chemistry, 2012, Balaydın, Halis T. et. al.
Effect of ethanol on fluoroquinolone efficacy in a rat model of pneumococcal pneumonia.
score: 1.1548291, Antimicrobial agents and chemotherapy, 2006, Olsen, Keith M et. al.
Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.
score: 1.1547929, Antimicrobial agents and chemotherapy, 2012, Legrand, Eric et. al.
OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii.
score: 1.1547807, Antimicrobial agents and chemotherapy, 2004, Girlich, Delphine; Naas, Thierry; Nordmann, Patrice
In vitro study of drug accumulation in cancer cells via specific association with CdS nanoparticles
score: 1.1547617, Bioorganic & Medicinal Chemistry Letters, 2006, Li, Jingyuan et. al.
8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs)
score: 1.154755, Bioorganic & Medicinal Chemistry, 2006, Zeng, He-Ping et. al.
Polypseudorotaxanes of pegylated insulin with cyclodextrins: Application to sustained release system
score: 1.1547507, Bioorganic & Medicinal Chemistry Letters, 2007, Higashi, Taishi et. al.
Development of enzyme-activated photosensitizer based on intramolecular electron transfer
score: 1.1547272, Bioorganic & Medicinal Chemistry Letters, 2010, Yogo, Takatoshi et. al.
Use of an efflux pump inhibitor to determine the prevalence of efflux pump-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa.
score: 1.1546499, Antimicrobial agents and chemotherapy, 2005, Kriengkauykiat, Jane et. al.
Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141.
score: 1.1546307, Antimicrobial agents and chemotherapy, 2004, Mouton, Johan W et. al.
Role of Aspergillus lentulus 14-α Sterol Demethylase (Cyp51A) in Azole Drug Susceptibility.
score: 1.1546087, Antimicrobial agents and chemotherapy, 2011, Mellado, Emilia et. al.
Photoprotective activity of resveratrol analogues
score: 1.1545413, Bioorganic & Medicinal Chemistry, 2013, Polonini, Hudson Caetano et. al.
1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative
score: 1.154521, Bioorganic & Medicinal Chemistry Letters, 2004, Li, Yiming et. al.
An Efficient Approach to the Synthesis of 1,3-Diaryl-1,2,3,4-[4H]-tetrahydronaphthalene-2-carboxylic Acids
score: 1.1544936, Bioorganic & Medicinal Chemistry, 1998, Xiang, Jia-Ning et. al.
Characteristics of NDM-1-producing Escherichia coli isolates that belong to the successful and virulent clone ST131.
score: 1.1544399, Antimicrobial agents and chemotherapy, 2011, Peirano, Gisele; Schreckenberger, Paul C; Pitout, Johann D D
Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT2-selective melatonin agonists: Improving metabolic stability
score: 1.1544013, Bioorganic & Medicinal Chemistry, 2013, Hu, Yueqing; Zhu, Jing; Chan, King H.; Wong, Yung H.
Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia.
score: 1.154318, Antimicrobial agents and chemotherapy, 2011, Tejman-Yarden, Noa et. al.
Garenoxacin treatment of experimental endocarditis caused by viridans group streptococci.
score: 1.1542638, Antimicrobial agents and chemotherapy, 2006, Anguita-Alonso, Paloma et. al.
Glucose-aspirin: synthesis and in vitro anti-cancer activity studies
score: 1.1542316, Bioorganic & Medicinal Chemistry Letters, 2012, Jacob, James N.; Tazawa, Makio J.
High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti region of Ghana.
score: 1.154133, Antimicrobial agents and chemotherapy, 2005, Marks, Florian et. al.
Powerful bactericidal activity of moxifloxacin in human leprosy.
score: 1.1540525, Antimicrobial agents and chemotherapy, 2008, Pardillo, Fe Eleanor F et. al.
Carrier PNA for shRNA delivery into cells
score: 1.154018, Bioorganic & Medicinal Chemistry Letters, 2009, Kitamatsu, Mizuki et. al.
Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library.
score: 1.1539964, Antimicrobial agents and chemotherapy, 2003, Scherman, Michael S et. al.
Affinities of beta-lactams for penicillin binding proteins of Chlamydia trachomatis and their antichlamydial activities.
score: 1.1539908, Antimicrobial agents and chemotherapy, 2001, Storey, C; Chopra, I
Tannic acid inhibited norovirus binding to HBGA receptors, a study of 50 Chinese medicinal herbs
score: 1.153959, Bioorganic & Medicinal Chemistry, 2012, Zhang, Xu-Fu et. al.
A microgonotropen pentaaza pentabutylamine and its interactions with DNA
score: 1.1538842, Bioorganic & Medicinal Chemistry, 1996, Sengupta, Dipanjan; Blaskó, Andrei; Bruice, Thomas C.
Synthesis and evaluation of new ω-borono-α-amino acids as rat liver arginase inhibitors
score: 1.153866, Bioorganic & Medicinal Chemistry, 2005, Busnel, Olivier et. al.
Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4 H)-anthracenone derivatives on tumor cell respiration
score: 1.1538199, Bioorganic & Medicinal Chemistry, 2006, Araya-Maturana, Ramiro et. al.
Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds.
score: 1.153781, Antimicrobial agents and chemotherapy, 2001, Balagué, C; Véscovi, E G
In vitro and in vivo antibacterial activities of DW-224a, a new fluoronaphthyridone.
score: 1.1537742, Antimicrobial agents and chemotherapy, 2006, Park, Hee-Soo et. al.
Effect of milk thistle on the pharmacokinetics of darunavir-ritonavir in HIV-infected patients.
score: 1.1537606, Antimicrobial agents and chemotherapy, 2012, Moltó, José et. al.
Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.
score: 1.1535403, Antimicrobial agents and chemotherapy, 1999, Khanh, N X et. al.
First and unexpected synthesis of macrocyclic cyclophane-based unusual α-amino acid derivatives by phosphazene base without high dilution conditions
score: 1.1535319, Bioorganic & Medicinal Chemistry Letters, 2002, Kotha, Sambasivarao et. al.
Propranolol inhibits hyphal development in Candida albicans.
score: 1.1534803, Antimicrobial agents and chemotherapy, 2002, Baker, Carol A; Desrosiers, Kevin; Dolan, Joseph W
Effect of Chinese medicine alpinetin on the structure of human serum albumin
score: 1.1534764, Bioorganic & Medicinal Chemistry, 2005, He, Wenying et. al.
Induction of apoptosis of human tumor cells by hybrid liposomes including docosahexaenoic acid
score: 1.1534477, Bioorganic & Medicinal Chemistry Letters, 2008, Goto, Koichi et. al.
Identification of VanN-Type Vancomycin Resistance in an Enterococcus faecium Isolate from Chicken Meat in Japan.
score: 1.1534475, Antimicrobial agents and chemotherapy, 2012, Nomura, Takahiro et. al.
Pharmacodynamics of itraconazole against Aspergillus fumigatus in an in vitro model of the human alveolus: perspectives on the treatment of triazole-resistant infection and utility of airway administration.
score: 1.1534111, Antimicrobial agents and chemotherapy, 2012, Al-Nakeeb, Zaid et. al.
Immunogens related to the synthetic tetrasaccharide side chain of the Bacillus anthracis exosporium
score: 1.1534087, Bioorganic & Medicinal Chemistry, 2007, Saksena, Rina; Adamo, Roberto; Kováč, Pavol
Effects of 8-chlorodeoxyadenosine on DNA synthesis by the klenow fragment of DNA polymerase I
score: 1.1533563, Bioorganic & Medicinal Chemistry Letters, 2003, Chen, Lisa S.; Bahr, Michael H.; Sheppard, Terry L.
QSAR treatment of drugs transfer into human breast milk
score: 1.1533189, Bioorganic & Medicinal Chemistry, 2005, Katritzky, Alan R. et. al.
Sensitization to p-amino aromatic compounds: Study of the covalent binding of 2,5-dimethyl- p-benzoquinonediimine to a model peptide by electrospray ionization tandem mass spectrometry
score: 1.1533151, Bioorganic & Medicinal Chemistry, 2008, Eilstein, Joan et. al.
Nonmolecular test for detection of low-level resistance to fluoroquinolones in Streptococcus pneumoniae.
score: 1.153267, Antimicrobial agents and chemotherapy, 2006, Varon, Emmanuelle et. al.
Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy
score: 1.1531607, Bioorganic & Medicinal Chemistry Letters, 2005, Chen, Yihui et. al.
Modified virulence of antibiotic-induced Burkholderia pseudomallei filaments.
score: 1.1531357, Antimicrobial agents and chemotherapy, 2005, Chen, Kang; Sun, Guang Wen; Chua, Kim Lee; Gan, Yunn-Hwen
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
score: 1.15312, Antimicrobial agents and chemotherapy, 2006, Robicsek, A et. al.
Feasibility of an immunoassay for mevalonolactone
score: 1.1530993, Bioorganic & Medicinal Chemistry, 1997, Spencer, Thomas A. et. al.
Electrochemical activity of holotransferrin and its electrocatalysis-mediated process of artemisinin
score: 1.1530824, Bioorganic & Medicinal Chemistry Letters, 2009, Cai, Huai-Hong; Cai, Jiye; Yang, Pei-Hui
Mode of action of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus.
score: 1.1530527, Antimicrobial agents and chemotherapy, 1998, Ono, N et. al.
Novel ciprofloxacin-resistant, nalidixic acid-susceptible mutant of Staphylococcus aureus.
score: 1.1528999, Antimicrobial agents and chemotherapy, 2002, Piddock, Laura J V et. al.
Photoregulation of DNA polymerase I (Klenow) with caged fluorescent oligodeoxynucleotides
score: 1.1528825, Bioorganic & Medicinal Chemistry Letters, 2005, Tang, XinJing et. al.
Camptothecins in tumor homing via an RGD sequence mimetic
score: 1.1527494, Bioorganic & Medicinal Chemistry Letters, 2012, Alloatti, Domenico et. al.
Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546)
score: 1.1526019, Bioorganic & Medicinal Chemistry, 2003, Glinka, Tomasz et. al.
Modulation of fibronectin adhesins and other virulence factors in a teicoplanin-resistant derivative of methicillin-resistant Staphylococcus aureus.
score: 1.1525975, Antimicrobial agents and chemotherapy, 2004, Renzoni, Adriana et. al.
Biosynthesis of agglomerin A: stereospecific incorporation of pro- R- and pro- S-hydrogens at sn-C-3 of glycerol into the branched C 3 moiety
score: 1.1525828, Bioorganic & Medicinal Chemistry Letters, 2004, Mashimo, Youichi et. al.
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[ b][1,6]naphthyridin-(5 H)ones
score: 1.1525765, Bioorganic & Medicinal Chemistry, 2005, Deady, Leslie W. et. al.
Complementary characteristics of homologous p-octiphenyl β-barrels with ion channel and esterase activity
score: 1.1525585, Bioorganic & Medicinal Chemistry, 2003, Som, Abhigyan; Sakai, Naomi; Matile, Stefan
Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides
score: 1.1524495, Bioorganic & Medicinal Chemistry, 1999, Huwe, Christoph M et. al.
Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives
score: 1.1523673, Bioorganic & Medicinal Chemistry, 2005, Sondhi, Sham M.; Singh, Nirupma; Johar, Monika; Kumar, Ashok
Stereochemical Selectivity of Methanandamides for the CB1 and CB2 Cannabinoid Receptors and Their Metabolic Stability
score: 1.1523561, Bioorganic & Medicinal Chemistry, 2001, Goutopoulos, Andreas et. al.
Rediscovery of natural products using genomic tools
score: 1.1523146, Bioorganic & Medicinal Chemistry Letters, 2006, Kawamura, Akira et. al.
Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine.
score: 1.1522437, Antimicrobial agents and chemotherapy, 2010, Yardley, Vanessa; Gamarro, Francisco; Croft, Simon L
Use of apple seed meal as a new source of β-glucosidase for enzymatic glucosylation of 4-substituted benzyl alcohols and tyrosol in monophasic aqueous-dioxane medium
score: 1.1522023, Bioorganic & Medicinal Chemistry Letters, 2004, Min Tong, Ai; Ya Lu, Wen; He Xu, Jian; Qiang Lin, Guo
Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli.
score: 1.1521005, Antimicrobial agents and chemotherapy, 2004, Hansen, Lars Hestbjerg et. al.
Optimal sampling schedule design for populations of patients.
score: 1.1520824, Antimicrobial agents and chemotherapy, 2003, Tam, Vincent H; Preston, Sandra L; Drusano, G L
Modified mannose disaccharides as substrates and inhibitors of a polyprenol monophosphomannose-dependent α-(1→6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis
score: 1.1520788, Bioorganic & Medicinal Chemistry, 2005, Subramaniam, Vinodhkumar et. al.
Pharmacodynamics of daptomycin in a murine thigh model of Staphylococcus aureus infection.
score: 1.1520644, Antimicrobial agents and chemotherapy, 2001, Louie, A et. al.
Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma
score: 1.1519926, Bioorganic & Medicinal Chemistry Letters, 2005, Huang, He-Qing et. al.
Vancomycin treatment failure associated with heterogeneous vancomycin-intermediate Staphylococcus aureus in a patient with endocarditis and in the rabbit model of endocarditis.
score: 1.1519767, Antimicrobial agents and chemotherapy, 2003, Moore, Matthew R et. al.
Synthesis and biological evaluation of a novel 99mTc nitrido radiopharmaceutical with deoxyglucose dithiocarbamate, showing tumor uptake
score: 1.1519597, Bioorganic & Medicinal Chemistry Letters, 2009, Zhang, Junbo; Ren, Jialei; Lin, Xiao; Wang, Xuebin
In vitro antiplasmodial activities of semisynthetic N, N′-spacer-linked oligomeric ergolines
score: 1.1519508, Bioorganic & Medicinal Chemistry, 2004, Jenett-Siems, Kristina et. al.
Ferrocene tripeptide Gly-Pro-Arg conjugates: Synthesis and inhibitory effects on Alzheimer’s Aβ1–42 fibrillogenesis and Aβ-induced cytotoxicity in vitro
score: 1.1519482, Bioorganic & Medicinal Chemistry, 2013, Zhou, Binbin et. al.
Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages.
score: 1.1518794, Antimicrobial agents and chemotherapy, 2002, Münch, Jan et. al.
Bifunctional agents for reperfusion arrhythmias: Novel hybrid vitamin E/Class I antiarrhythmics
score: 1.151839, Bioorganic & Medicinal Chemistry, 2003, Koufaki, Maria et. al.
On the chemistry of RNA degradation by Fe·bleomycin
score: 1.151833, Bioorganic & Medicinal Chemistry, 1997, Holmes, Chris E. et. al.
Echinocandin susceptibility testing of Candida spp. Using EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: analysis of the influence of bovine serum albumin supplementation, storage time, and drug lots.
score: 1.1517847, Antimicrobial agents and chemotherapy, 2011, Arendrup, Maiken Cavling et. al.
Postantibiotic, postantibiotic sub-MIC, and subinhibitory effects of PGE-9509924, ciprofloxacin, and levofloxacin.
score: 1.1517634, Antimicrobial agents and chemotherapy, 2003, Odenholt, Inga; Löwdin, Elisabeth; Cars, Otto
Synthesis and biological evaluation of 2-amino-2-deoxy- and 6-amino-6-deoxy-cyclomaltoheptaose polysulfates as synergists for angiogenesis inhibition
score: 1.1516515, Bioorganic & Medicinal Chemistry, 1996, Sakairi, Nobuo et. al.
Evaluation of CLSI M44-A2 disk diffusion and associated breakpoint testing of caspofungin and micafungin using a well-characterized panel of wild-type and fks hot spot mutant Candida isolates.
score: 1.1516483, Antimicrobial agents and chemotherapy, 2011, Arendrup, Maiken Cavling et. al.
Resistance Gene Transfer during Treatments for Experimental Avian Colibacillosis.
score: 1.1516165, Antimicrobial agents and chemotherapy, 2012, Dheilly, Alexandra et. al.
Immunostimulation by plant polyphenols: A relationship between tumor necrosis factor-α production and tannin structure
score: 1.1515144, Bioorganic & Medicinal Chemistry Letters, 1999, Feldman, Ken S. et. al.
Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin
score: 1.1514718, Bioorganic & Medicinal Chemistry, 2007, Brown, Toni et. al.
Reaction of 2,2,5,7,8-pentamethyl-6-chromanol, an α-tocopherol analogue, with NO in the presence of oxygen
score: 1.1514345, Bioorganic & Medicinal Chemistry Letters, 2000, Nagata, Yoshiko et. al.
Urinary excretion and bactericidal activities of gemifloxacin and ofloxacin after a single oral dose in healthy volunteers.
score: 1.1514173, Antimicrobial agents and chemotherapy, 2001, Naber, C K et. al.
NMR detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli
score: 1.151386, Bioorganic & Medicinal Chemistry Letters, 2007, Yao, Yong et. al.
Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis.
score: 1.151384, Antimicrobial agents and chemotherapy, 2012, Zhang, Ming et. al.
In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model.
score: 1.1513723, Antimicrobial agents and chemotherapy, 2006, Fukuda, Yuichi et. al.
Case report of a successful treatment of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and MRSA/vancomycin-resistant Enterococcus faecium cholecystitis by daptomycin.
score: 1.1511893, Antimicrobial agents and chemotherapy, 2011, Tascini, Carlo et. al.
Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases
score: 1.1511683, Bioorganic & Medicinal Chemistry, 1999, Brown, Pamela et. al.
TLA-1: a new plasmid-mediated extended-spectrum beta-lactamase from Escherichia coli.
score: 1.1510699, Antimicrobial agents and chemotherapy, 2000, Silva, J et. al.
Interactions of quinupristin-dalfopristin with eight other antibiotics as measured by time-kill studies with 10 strains of Staphylococcus aureus for which quinupristin-dalfopristin alone was not bactericidal.
score: 1.1510565, Antimicrobial agents and chemotherapy, 2001, Fuchs, P C; Barry, A L; Brown, S D
Antimicrobial susceptibilities of a worldwide collection of Stenotrophomonas maltophilia isolates tested against tigecycline and agents commonly used for S. maltophilia infections.
score: 1.1510446, Antimicrobial agents and chemotherapy, 2010, Farrell, David J; Sader, Helio S; Jones, Ronald N
From triplex to B-form duplex stabilization: reversal of target selectivity by aminoglycoside dimers
score: 1.1510176, Bioorganic & Medicinal Chemistry Letters, 2004, Arya, Dev P.; Coffee, R. Lane; Xue, Liang
In vitro selection of variants resistant to beta-lactams plus beta-lactamase inhibitors in CTX-M beta-lactamases: predicting the in vivo scenario?
score: 1.1509645, Antimicrobial agents and chemotherapy, 2011, Ripoll, Aida et. al.
Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution and effect of food.
score: 1.1509431, Antimicrobial agents and chemotherapy, 1998, Abdel-Rahman, S M; Kearns, G L
Regulation of mprF by antisense RNA restores daptomycin susceptibility to daptomycin-resistant isolates of Staphylococcus aureus.
score: 1.150943, Antimicrobial agents and chemotherapy, 2011, Rubio, Aileen et. al.
2,2-Dimethyl-2 H-anthra[2,3- b]pyran-6,11-diones: a new class of cytotoxic compounds
score: 1.1509396, Bioorganic & Medicinal Chemistry, 2001, Melliou, Eleni et. al.
Peritoneal fluid titer test for peritoneal dialysis-related peritonitis.
score: 1.1509107, Antimicrobial agents and chemotherapy, 2004, Strijack, Christine et. al.
Activities of gemifloxacin (SB 265805, LB20304) compared to those of other oral antimicrobial agents against unusual anaerobes.
score: 1.1508476, Antimicrobial agents and chemotherapy, 1999, Goldstein, E J et. al.
Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli.
score: 1.1508095, Antimicrobial agents and chemotherapy, 2012, Ortega, Adriana et. al.
Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta-lactamase gene blaIMP.
score: 1.1507833, Antimicrobial agents and chemotherapy, 1998, Hirakata, Y et. al.
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine.
score: 1.1507291, Antimicrobial agents and chemotherapy, 2006, Jacquard, A-C et. al.
Melanocyte-Directed enzyme prodrug therapy (MDEPT)
score: 1.150683, Bioorganic & Medicinal Chemistry, 2001, Jordan, Allan M. et. al.
Population pharmacokinetics of amphotericin B lipid complex in neonates.
score: 1.1505899, Antimicrobial agents and chemotherapy, 2005, Würthwein, Gudrun et. al.
Selection and characterization of a human monoclonal neutralizing antibody for Clostridium Botulinum neurotoxin serotype B
score: 1.1505345, Bioorganic & Medicinal Chemistry Letters, 2009, Zhou, Heyue et. al.
Synthesis and biological evaluation of novel turn-modified gramicidin S analogues
score: 1.1505046, Bioorganic & Medicinal Chemistry, 2003, Grotenbreg, Gijsbert M et. al.
Discovery of new peptide-Based catalysts for the direct asymmetric aldol reaction
score: 1.1504787, Bioorganic & Medicinal Chemistry Letters, 2003, Kofoed, Jacob; Nielsen, John; Reymond, Jean-Louis
Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity
score: 1.1504157, European Journal of Medicinal Chemistry, 2003, Gallo, Sandrine et. al.
Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive cells.
score: 1.1504108, Antimicrobial agents and chemotherapy, 2011, Kim, Jun-Seob et. al.
Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus.
score: 1.1502833, Antimicrobial agents and chemotherapy, 2004, Underwood, Mark R et. al.
Air to liver partition coefficients for volatile organic compounds and blood to liver partition coefficients for volatile organic compounds and drugs
score: 1.1501012, European Journal of Medicinal Chemistry, 2007, Abraham, Michael H.; Ibrahim, Adam; Acree, William E.
Evaluation of vancomycin and daptomycin potency trends (MIC creep) against methicillin-resistant Staphylococcus aureus isolates collected in nine U.S. medical centers from 2002 to 2006.
score: 1.1500821, Antimicrobial agents and chemotherapy, 2009, Sader, Helio S et. al.
Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco
score: 1.1500726, Bioorganic & Medicinal Chemistry, 2004, Hernández, Juan C et. al.
Novel 6-Hydroxy-3-morpholinones as cornea permeable calpain inhibitors
score: 1.1500659, Bioorganic & Medicinal Chemistry, 2003, Nakamura, Masayuki et. al.
pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia.
score: 1.1500429, Antimicrobial agents and chemotherapy, 2003, Lim, Pharath et. al.
Transmission-blocking activities of quinine, primaquine, and artesunate.
score: 1.1499703, Antimicrobial agents and chemotherapy, 2006, Chotivanich, Kesinee et. al.
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
score: 1.1499612, Antimicrobial agents and chemotherapy, 2002, Yardley, Vanessa et. al.
Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease
score: 1.1499388, Bioorganic & Medicinal Chemistry, 1999, Ogilvie, W.W. et. al.
Deep-red fluorescent imaging probe for bacteria
score: 1.1499368, Bioorganic & Medicinal Chemistry Letters, 2012, White, Alexander G. et. al.
Pyrrolidine as a cogwheel-like scaffold for the deployment of diverse functionality through cycloaddition reactions of metallo-1,3-dipoles in aqueous media
score: 1.1497979, Bioorganic & Medicinal Chemistry Letters, 2000, Hanessian, Stephen; Bayrakdarian, Malken
Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis.
score: 1.1496881, Antimicrobial agents and chemotherapy, 2003, Betts, Joanna C et. al.
Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities
score: 1.1496007, Bioorganic & Medicinal Chemistry Letters, 2012, Chang, Minsun et. al.
Antibiotic susceptibility patterns of Neisseria meningitidis isolates from patients and asymptomatic carriers.
score: 1.1495712, Antimicrobial agents and chemotherapy, 2000, Arreaza, L; de La Fuente, L; Vázquez, J A
Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria.
score: 1.1495106, Antimicrobial agents and chemotherapy, 2004, Karunajeewa, Harin A et. al.
Oritavancin activity against vancomycin-susceptible and vancomycin-resistant Enterococci with molecularly characterized glycopeptide resistance genes recovered from bacteremic patients, 2009-2010.
score: 1.1495077, Antimicrobial agents and chemotherapy, 2012, Mendes, Rodrigo E et. al.
Certification of the Critical Importance of l-3-(2-Naphthyl)alanine at Position 3 of a Specific CXCR4 Inhibitor, T140, Leads to an Exploratory Performance of Its Downsizing Study
score: 1.149495, Bioorganic & Medicinal Chemistry, 2002, Tamamura, Hirokazu et. al.
Influence of DNA template choice on transcription and inhibition of Escherichia coli RNA polymerase.
score: 1.1494891, Antimicrobial agents and chemotherapy, 2012, Haupenthal, Joerg et. al.
Hypervalent iodine-catalyzed oxylactonization of ketocarboxylic acids to ketolactones
score: 1.1494369, Bioorganic & Medicinal Chemistry Letters, 2009, Uyanik, Muhammet; Yasui, Takeshi; Ishihara, Kazuaki
Urinary bactericidal activity of extended-release ciprofloxacin (1,000 milligrams) versus levofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose.
score: 1.1493575, Antimicrobial agents and chemotherapy, 2006, Wagenlehner, Florian M E et. al.
Chemical Modification of the β-Glucocerebrosidase Inhibitor N-Octyl-β-valienamine: Synthesis and Biological Evaluation of 4-Epimeric and 4- O-(β- d-Galactopyranosyl) Derivatives
score: 1.1493501, Bioorganic & Medicinal Chemistry, 2002, Ogawa, Seiichiro et. al.
An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin.
score: 1.1493332, Antimicrobial agents and chemotherapy, 2002, Singh, Kavindra V; Weinstock, George M; Murray, Barbara E
Design, synthesis and preliminary biological evaluation of a focused combinatorial library of stereodiverse carbohydrate-scaffold-based peptidomimetics
score: 1.1491832, Bioorganic & Medicinal Chemistry, 2001, Moitessier, Nicolas et. al.
D-Ala-d-Ser VanN-type transferable vancomycin resistance in Enterococcus faecium.
score: 1.1491263, Antimicrobial agents and chemotherapy, 2011, Lebreton, François et. al.
α- l-RNA (α- l- ribo Configured RNA): Synthesis and RNA-Selective Hybridization of α- l-RNA/α- l-LNA Chimera
score: 1.1491109, Bioorganic & Medicinal Chemistry Letters, 2002, Keinicke, Lise; Sørensen, Mads D.; Wengel, Jesper
Absolute stereostructures of polypodane- and octanordammarane-type triterpenes with nitric oxide production inhibitory activity from guggul-gum resins
score: 1.1490489, Bioorganic & Medicinal Chemistry, 2004, Matsuda, Hisashi et. al.
A novel 99mTc-labeled testosterone derivative as a potential agent for targeting androgen receptors
score: 1.1489677, Bioorganic & Medicinal Chemistry Letters, 2006, Das, Tapas et. al.
Evidences for adduct formation between intracellular non-protein thiols and nitroazoles possessing an α,β-unsaturated carbonyl side chain and the effects on radiosensitization of hypoxic cells
score: 1.1488844, Bioorganic & Medicinal Chemistry, 1999, Zhou, Ling; Ino, Akira; Dai, Wei-Min; Nishimoto, Sei-ichi
Efficacy of oral cochleate-amphotericin B in a mouse model of systemic candidiasis.
score: 1.1488676, Antimicrobial agents and chemotherapy, 2000, Santangelo, R et. al.
Immunostimulatory activity of CpG containing phosphorothioate oligodeoxynucleotide is modulated by modification of a single deoxynucleoside
score: 1.1488444, Bioorganic & Medicinal Chemistry Letters, 2000, Zhao, Qiuyan; Yu, Dong; Agrawal, Sudhir
Comparative pharmacokinetics of continuous and conventional intrathecal amphotericin B in rabbits.
score: 1.148672, Antimicrobial agents and chemotherapy, 2012, Fang, Min et. al.
Detection of resistance to amphotericin B in Candida isolates by using Iso-Sensitest broth.
score: 1.1486481, Antimicrobial agents and chemotherapy, 2001, Cuenca-Estrella, M et. al.
Phenotypic susceptibilities to tenofovir in a large panel of clinically derived human immunodeficiency virus type 1 isolates.
score: 1.1485915, Antimicrobial agents and chemotherapy, 2002, Harrigan, P R et. al.
Synthesis and anti-HIV activity of nonatyrosine N- and O 1–9-decasulfate
score: 1.1485493, Bioorganic & Medicinal Chemistry, 2001, Ueki, Masaaki et. al.
In vitro monitoring of Plasmodium falciparum drug resistance in French Guiana: a synopsis of continuous assessment from 1994 to 2005.
score: 1.1485366, Antimicrobial agents and chemotherapy, 2008, Legrand, Eric et. al.
In vitro and murine efficacy and toxicity studies of nebulized SCC1, a methylated caffeine-silver(I) complex, for treatment of pulmonary infections.
score: 1.1484932, Antimicrobial agents and chemotherapy, 2009, Cannon, Carolyn L et. al.
Mechanism of the intracellular killing and modulation of antibiotic susceptibility of Listeria monocytogenes in THP-1 macrophages activated by gamma interferon.
score: 1.1483855, Antimicrobial agents and chemotherapy, 1999, Ouadrhiri, Y; Scorneaux, B; Sibille, Y; Tulkens, P M
In vitro activities of nontraditional antimicrobials against multiresistant Acinetobacter baumannii strains isolated in an intensive care unit outbreak.
score: 1.1483643, Antimicrobial agents and chemotherapy, 2000, Appleman, M D et. al.
Indolo[3,2- c]cinnolines with antiproliferative, antifungal, and antibacterial activity
score: 1.1483245, Bioorganic & Medicinal Chemistry, 1999, Barraja, Paola et. al.
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
score: 1.1482939, Antimicrobial agents and chemotherapy, 2004, Feng, Joy Y et. al.
Sodium stibogluconate (Pentostam) potentiates oxidant production in murine visceral leishmaniasis and in human blood.
score: 1.1482777, Antimicrobial agents and chemotherapy, 2000, Rais, S et. al.
Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.
score: 1.1482115, Antimicrobial agents and chemotherapy, 2011, Campbell, Patricia J et. al.
Mechanism of action of the arylomycin antibiotics and effects of signal peptidase I inhibition.
score: 1.1481719, Antimicrobial agents and chemotherapy, 2012, Smith, Peter A; Romesberg, Floyd E
In vitro activities of six quinolones and mechanisms of resistance in Staphylococcus aureus and coagulase-negative staphylococci.
score: 1.1481008, Antimicrobial agents and chemotherapy, 2001, Linde, H J et. al.
Detection of an anhydride intermediate in the carboxypeptidase A catalyzed hydrolysis of a peptide substrate by solid state NMR spectroscopy and its mechanistic implication
score: 1.1481003, Bioorganic & Medicinal Chemistry Letters, 1998, Lee, Hee Cheon; Ko, Young Ho; Baek, Seung Bin; Kim, Dong H
Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone
score: 1.1480895, European Journal of Medicinal Chemistry, 2009, Li, Yong; Yang, Zheng-Yin; Wang, Ming-Fang
Type II topoisomerase quinolone resistance-determining regions of Aeromonas caviae, A. hydrophila, and A. sobria complexes and mutations associated with quinolone resistance.
score: 1.1479103, Antimicrobial agents and chemotherapy, 2002, Goñi-Urriza, Marisol et. al.
Structural diversity through intramolecular cycloaddition and modulation of chemical reactivity in excited state. Synthesis and photoreactions of 3-oxa-tricyclo[5.2.2.0 1,5]undecenones: novel stereoselective route to oxa-triquinanes and oxa-sterpuranes
score: 1.1479048, Bioorganic & Medicinal Chemistry Letters, 2000, Singh, Vishwakarma; Alam, S.Q.
Synthesis of vanadyl–hypocrellin A complex and its photodynamic properties research
score: 1.1478625, Bioorganic & Medicinal Chemistry Letters, 2012, Yang, Chao et. al.
Molecular design of multifunctional antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA)
score: 1.147831, Bioorganic & Medicinal Chemistry, 2003, Kubo, Isao; Fujita, Ken-ichi; Nihei, Ken-ichi
Ribosomal P0 protein domain involved in selectivity of antifungal sordarin derivatives.
score: 1.1478233, Antimicrobial agents and chemotherapy, 2004, Santos, C et. al.
Investigation of metronidazole use during pregnancy and adverse birth outcomes.
score: 1.1478227, Antimicrobial agents and chemotherapy, 2012, Koss, Catherine A et. al.
Anti-cancer activities of 5-acyl-6-[2-hydroxy/benzyloxy-3-(amino)-propylamino]-1,3-dialkyl-1 H-pyrimidin-2,4-diones
score: 1.1477759, Bioorganic & Medicinal Chemistry, 2006, Singh, Palwinder; Paul, Kamaldeep
Synthesis and biochemical investigation of scyphostatin analogues as inhibitors of neutral sphingomyelinase
score: 1.147756, Bioorganic & Medicinal Chemistry, 2001, Arenz, Christoph et. al.
Travels of an organic chemist along nature's pathways
score: 1.1477363, Bioorganic & Medicinal Chemistry, 1996, Scott, A.Ian
Intracellular and plasma pharmacokinetics of saquinavir-ritonavir, administered at 1,600/100 milligrams once daily in human immunodeficiency virus-infected patients.
score: 1.1476039, Antimicrobial agents and chemotherapy, 2004, Ford, Jennifer et. al.
Development of Rationally Designed DNA N6 Adenine Methyltransferase Inhibitors
score: 1.1476027, Bioorganic & Medicinal Chemistry Letters, 2012, Hobley, Gerard et. al.
Clinical and economic impact of common multidrug-resistant gram-negative bacilli.
score: 1.1475953, Antimicrobial agents and chemotherapy, 2008, Giske, Christian G et. al.
Photoirradiation products of flavin derivatives, and the effects of photooxidation on guanine
score: 1.1475016, Bioorganic & Medicinal Chemistry Letters, 2009, Kino, Katsuhito et. al.
Identification of a Serratia marcescens clinical isolate with multiple quinolone resistance mechanisms from China.
score: 1.1474789, Antimicrobial agents and chemotherapy, 2012, Yang, Hai-Fei; Cheng, Jun; Hu, Li-Fen; Ye, Ying; Li, Jia-Bin
Plasmid-mediated quinolone resistance in extended-spectrum-β-lactamase- and AmpC β-lactamase-producing Serratia marcescens in China.
score: 1.1474789, Antimicrobial agents and chemotherapy, 2012, Yang, Hai-Fei; Cheng, Jun; Hu, Li-Fen; Ye, Ying; Li, Jia-Bin
Factors affecting anti-inflammatory effect of chitooligosaccharides in lipopolysaccharides-induced RAW264.7 macrophage cells
score: 1.1474774, Bioorganic & Medicinal Chemistry Letters, 2009, Lee, Sang-Hoon et. al.
Detection of grlA and gyrA mutations in 344 Staphylococcus aureus strains.
score: 1.1474666, Antimicrobial agents and chemotherapy, 1998, Wang, T; Tanaka, M; Sato, K
Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes.
score: 1.1473178, Antimicrobial agents and chemotherapy, 2011, Sader, Helio S et. al.
Pharmacodynamics of ceftazidime plus the serine beta-lactamase inhibitor AM-112 against Escherichia coli containing TEM-1 and CTX-M-1 beta-lactamases.
score: 1.1472723, Antimicrobial agents and chemotherapy, 2004, Bowker, Karen E et. al.
Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections.
score: 1.1472016, Antimicrobial agents and chemotherapy, 2006, Van Wart, S A et. al.
Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil.
score: 1.1471617, Antimicrobial agents and chemotherapy, 2000, Dalla Costa, L M et. al.
Resistance to the peptidyl transferase inhibitor tiamulin caused by mutation of ribosomal protein l3.
score: 1.1471444, Antimicrobial agents and chemotherapy, 2003, Bøsling, Jacob et. al.
Synthesis of photoactivable inhibitors of osteoclast vacuolar ATPase
score: 1.1470065, Bioorganic & Medicinal Chemistry, 2003, Biasotti, Barbara et. al.
Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity.
score: 1.1470064, Antimicrobial agents and chemotherapy, 2004, Sader, Helio S et. al.
Organocatalysis with endogenous compounds: Towards novel non-enzymatic reactions
score: 1.1469402, Bioorganic & Medicinal Chemistry Letters, 2009, Alberg, David G. et. al.
Promising antituberculosis activity of the oxazolidinone PNU-100480 relative to that of linezolid in a murine model.
score: 1.1469198, Antimicrobial agents and chemotherapy, 2009, Williams, K N et. al.
Antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae isolates from elderly patients with pneumonia and acute exacerbation of chronic obstructive pulmonary disease.
score: 1.1468646, Antimicrobial agents and chemotherapy, 2011, Pérez-Trallero, Emilio et. al.
Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques.
score: 1.1467435, Antimicrobial agents and chemotherapy, 2011, Li, Youjia et. al.
Effect of ertapenem protein binding on killing of bacteria.
score: 1.1467386, Antimicrobial agents and chemotherapy, 2004, Nix, David E; Matthias, Kathryn R; Ferguson, Emily C
Dissemination and persistence of blaCTX-M-9 are linked to class 1 integrons containing CR1 associated with defective transposon derivatives from Tn402 located in early antibiotic resistance plasmids of IncHI2, IncP1-alpha, and IncFI groups.
score: 1.1467141, Antimicrobial agents and chemotherapy, 2006, Novais, Angela et. al.
Design, synthesis, and biological activity of novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives
score: 1.1466871, Bioorganic & Medicinal Chemistry, 2004, Liu, Chang-Ling; Li, Lin; Li, Zheng-Ming
Comparative in vitro activities of ciprofloxacin, gemifloxacin, grepafloxacin, moxifloxacin, ofloxacin, sparfloxacin, trovafloxacin, and other antimicrobial agents against bloodstream isolates of gram-positive cocci.
score: 1.1466839, Antimicrobial agents and chemotherapy, 2000, Hardy, D; Amsterdam, D; Mandell, L A; Rotstein, C
Characterization of an In vitro-selected amoxicillin-resistant strain of Helicobacter pylori.
score: 1.146626, Antimicrobial agents and chemotherapy, 2000, DeLoney, C R; Schiller, N L
Synthesis and DNA binding properties of terminally modified peptide nucleic acids
score: 1.1466128, Bioorganic & Medicinal Chemistry Letters, 2003, Mokhir, Andriy et. al.
Convenient methods for the synthesis of P 1-farnesyl- P 2-indicator diphosphates
score: 1.1466062, Bioorganic & Medicinal Chemistry Letters, 2006, Feld, Birte K.; Weiss, Gregory A.
Abbott Physicochemical Tiering (APT)—A unified approach to HTS triage
score: 1.1464609, Bioorganic & Medicinal Chemistry, 2012, Cox, Philip B.; Gregg, Robert J.; Vasudevan, Anil
In vitro activities of daptomycin against 2,789 clinical isolates from 11 North American medical centers.
score: 1.1464275, Antimicrobial agents and chemotherapy, 2001, Barry, A L; Fuchs, P C; Brown, S D
Fate of mutation rate depends on agr locus expression during oxacillin-mediated heterogeneous-homogeneous selection in methicillin-resistant Staphylococcus aureus clinical strains.
score: 1.1463653, Antimicrobial agents and chemotherapy, 2011, Plata, Konrad B; Rosato, Roberto R; Rosato, Adriana E
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope.
score: 1.1462702, Antimicrobial agents and chemotherapy, 2010, Hoorelbeke, Bart et. al.
Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
score: 1.146266, Antimicrobial agents and chemotherapy, 2006, Yatsuji, Hiromi et. al.
In silico children and the glass mouse model: clinical trial simulations to identify and individualize optimal isoniazid doses in children with tuberculosis.
score: 1.1461259, Antimicrobial agents and chemotherapy, 2011, Jeena, Prakash M et. al.
Rapid high-throughput detection of peroxide with an acridinium-9-carboxamide: A homogeneous chemiluminescent assay for plasma choline
score: 1.1460595, Bioorganic & Medicinal Chemistry Letters, 2006, Adamczyk, Maciej et. al.
Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1.
score: 1.1460571, Antimicrobial agents and chemotherapy, 2005, Poirel, Laurent et. al.
“Cut and combine”: An easy membrane-supported combinatorial synthesis technique
score: 1.1460536, Bioorganic & Medicinal Chemistry Letters, 1998, Dittrich, Frank; Tegge, Werner; Frank, Ronald
Understanding topoisomerase I and II in terms of QSAR
score: 1.1460013, Bioorganic & Medicinal Chemistry, 2005, Verma, Rajeshwar P.
A biaryl peptide crosslink in a MetJ peptide model confers cooperative, nonspecific binding to DNA that ablates both repressor binding and In vitro transcription
score: 1.1459454, Bioorganic & Medicinal Chemistry, 2003, Yoburn, Joshua C et. al.
Isolation and Quantitation of Topoisomerase Complexes Accumulated on Escherichia coli Chromosomal DNA.
score: 1.1458829, Antimicrobial agents and chemotherapy, 2012, Aedo, Sandra; Tse-Dinh, Yuk-Ching
Lipase-catalysed selective deacetylation of phenolic/enolic acetoxy groups in peracetylated benzyl phenyl ketones
score: 1.1458816, Bioorganic & Medicinal Chemistry, 1998, Parmar, Virinder S. et. al.
Antibiotic susceptibilities of Parachlamydia acanthamoeba in amoebae.
score: 1.1458787, Antimicrobial agents and chemotherapy, 2002, Maurin, M; Bryskier, A; Raoult, D
Comparative efficacies of candidate antibiotics against Yersinia pestis in an in vitro pharmacodynamic model.
score: 1.1458755, Antimicrobial agents and chemotherapy, 2011, Louie, Arnold et. al.
First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses.
score: 1.1458478, Antimicrobial agents and chemotherapy, 2012, Painter, Wendy et. al.
Mechanism of action at the molecular level of the antiviral drug 3(2H)-isoflavene against type 2 poliovirus.
score: 1.1457432, Antimicrobial agents and chemotherapy, 2004, Salvati, Anna L et. al.
Estimation of serum-free 50-percent inhibitory concentrations for human immunodeficiency virus protease inhibitors lopinavir and ritonavir.
score: 1.1457281, Antimicrobial agents and chemotherapy, 2004, Hickman, Dean et. al.
Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones
score: 1.1457012, Bioorganic & Medicinal Chemistry, 2001, Neumann, Ulf; Schechter, Norman M.; Gütschow, Michael
Novel real-time monitoring system for human cytomegalovirus-infected cells in vitro that uses a green fluorescent protein-PML-expressing cell line.
score: 1.1456934, Antimicrobial agents and chemotherapy, 2006, Ueno, T et. al.
Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium falciparum malaria.
score: 1.1456856, Antimicrobial agents and chemotherapy, 2012, Lanaspa, Miguel et. al.
Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa.
score: 1.1456528, Antimicrobial agents and chemotherapy, 2004, Kruger, Tersia et. al.
Contributions of the AmpC beta-lactamase and the AcrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactams.
score: 1.1454973, Antimicrobial agents and chemotherapy, 2000, Mazzariol, A; Cornaglia, G; Nikaido, H
Fluorescent molecular probes V: A sensitive caspase-3 substrate for fluorometric assays
score: 1.1454697, Bioorganic & Medicinal Chemistry Letters, 1999, Jixiang Liu, et. al.
Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV of Enterococcus faecalis.
score: 1.1454604, Antimicrobial agents and chemotherapy, 2002, Onodera, Yoshikuni et. al.
Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and α-lipoic acid
score: 1.1453601, Bioorganic & Medicinal Chemistry, 2006, Venkatachalam, S.R. et. al.
Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC
score: 1.1453501, Bioorganic & Medicinal Chemistry Letters, 2001, Zhang, Alex J. et. al.
Activity of carbapenems combined with clavulanate against murine tuberculosis.
score: 1.1453196, Antimicrobial agents and chemotherapy, 2011, Veziris, Nicolas et. al.
Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae.
score: 1.1452371, Antimicrobial agents and chemotherapy, 2000, Jorgensen, J H et. al.
A quantitative structure–activity relationship study on some matrix metalloproteinase and collagenase inhibitors
score: 1.1452319, Bioorganic & Medicinal Chemistry, 2003, Kumar, Dalip; Gupta, S.P.
Genotypic characterization of the DNA polymerase and sensitivity to antiviral compounds of foscarnet-resistant herpes simplex virus type 1 (HSV-1) derived from a foscarnet-sensitive HSV-1 strain.
score: 1.1452254, Antimicrobial agents and chemotherapy, 2005, Saijo, Masayuki et. al.
Activities of newer fluoroquinolones against ciprofloxacin-resistant Streptococcus pneumoniae.
score: 1.1451211, Antimicrobial agents and chemotherapy, 2001, Coyle, E A; Kaatz, G W; Rybak, M J
Selection of a screening panel of rhinoviral serotypes
score: 1.1451194, Bioorganic & Medicinal Chemistry Letters, 2012, Tomkinson, Nick; Wenlock, Mark; McCrae, Chris
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles
score: 1.1449404, Bioorganic & Medicinal Chemistry, 2012, Holler, Jes Gitz et. al.
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles
score: 1.1449404, Bioorganic & Medicinal Chemistry, 2012, Holler, Jes Gitz et. al.
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles
score: 1.1449404, Bioorganic & Medicinal Chemistry, 2012, Holler, Jes Gitz et. al.
Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro.
score: 1.1448761, Antimicrobial agents and chemotherapy, 2002, Ohrt, Colin et. al.
Modulation of the activity of secretory phospholipase A2 by antimicrobial peptides.
score: 1.1448744, Antimicrobial agents and chemotherapy, 2003, Zhao, Hongxia; Kinnunen, Paavo K J
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells
score: 1.1447565, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Guanghui et. al.
Facile synthesis of N-protected γ and δ-Amino-β-Keto-esters
score: 1.1446861, Bioorganic & Medicinal Chemistry Letters, 1999, Baoqing, Li; Franck, Richard W.
Facile synthesis of N-protected γ and δ-Amino-β-Keto-esters
score: 1.1446861, Bioorganic & Medicinal Chemistry Letters, 1999, Baoqing, Li; Franck, Richard W.
Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus.
score: 1.1446436, Antimicrobial agents and chemotherapy, 2012, Pizzorno, Andrés et. al.
Reaction of reductively activated mitomycin C with aqueous bicarbonate: Isolation and characterization of an oxazolidinone derivative of cis-1-hydroxy-2,7-diaminomitosene
score: 1.1446047, Bioorganic & Medicinal Chemistry Letters, 2010, Paz, Manuel M.
Studies on the synthesis and biological activities of 4′-( R)-hydroxy-5′-( S)-hydroxymethyl-tetrahydrofuranyl purines and pyrimidines
score: 1.1444961, Bioorganic & Medicinal Chemistry, 1996, Yu, Hong-Wu et. al.
First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain.
score: 1.144226, Antimicrobial agents and chemotherapy, 2011, Pitart, Cristina et. al.
Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults.
score: 1.1441907, Antimicrobial agents and chemotherapy, 1998, Deeks, S G et. al.
α-cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents
score: 1.1441734, Bioorganic & Medicinal Chemistry, 2005, Bell, Roel P.L. et. al.
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.
score: 1.144138, Nature chemical biology, 2010, Christ, Frauke et. al.
Improved oxacillin treatment outcomes in experimental skin and lung infection by a methicillin-resistant Staphylococcus aureus isolate with a vraSR operon deletion.
score: 1.1441369, Antimicrobial agents and chemotherapy, 2011, Jo, Dae Sun et. al.
Antimicrobial activities of BMS-284756 compared with those of fluoroquinolones and beta-lactams against gram-positive clinical isolates.
score: 1.1441045, Antimicrobial agents and chemotherapy, 2002, Bassetti, Matteo et. al.
The first conversion of camptothecin to ( S)-mappicine by an efficient chemoenzymatic method
score: 1.1440855, Bioorganic & Medicinal Chemistry Letters, 1998, Das, Biswanath; Madhusudhan, P; Kashinatham, A
High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution.
score: 1.1439816, Antimicrobial agents and chemotherapy, 2004, Cartelle, Monica et. al.
Efficacy of minocycline and EDTA lock solution in preventing catheter-related bacteremia, septic phlebitis, and endocarditis in rabbits.
score: 1.1438736, Antimicrobial agents and chemotherapy, 2002, Raad, Issam et. al.
Prevalence and molecular genetics of macrolide resistance among Streptococcus pneumoniae isolates collected in Finland in 2002.
score: 1.1437364, Antimicrobial agents and chemotherapy, 2005, Rantala, M; Huikko, S; Huovinen, P; Jalava, J
QSAR study of antiplatelet agents
score: 1.1437086, Bioorganic & Medicinal Chemistry, 2006, Katritzky, Alan R. et. al.
Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics.
score: 1.1436992, Antimicrobial agents and chemotherapy, 1998, Wang, G; Taylor, D E
2,2′-dithiobisbenzamides derived from α-, β- and γ-amino acids possessing anti-HIV activities: synthesis and structure–activity relationship
score: 1.1436423, Bioorganic & Medicinal Chemistry, 1998, Vara Prasad, J.V.N et. al.
Comparison of the in vitro activity of the glycylcycline tigecycline (formerly GAR-936) with those of tetracycline, minocycline, and doxycycline against isolates of nontuberculous mycobacteria.
score: 1.1435843, Antimicrobial agents and chemotherapy, 2002, Wallace, Richard J et. al.
Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays.
score: 1.143412, Antimicrobial agents and chemotherapy, 2003, González, Gloria M et. al.
Staphylococcus aureus mutants selected by BMS-284756.
score: 1.1433895, Antimicrobial agents and chemotherapy, 2001, Discotto, L F; Lawrence, L E; Denbleyker, K L; Barrett, J F
Synthesis and Biological Activity of Both Enantiomers of Kujigamberol Isolated from 85-Million-Years-Old Kuji Amber
score: 1.1433388, Bioorganic & Medicinal Chemistry Letters, 2012, Ye, Yue Qi et. al.
Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones.
score: 1.14327, Antimicrobial agents and chemotherapy, 2005, Rafii, Fatemeh; Park, Miseon; Novak, John S
Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum.
score: 1.143256, Antimicrobial agents and chemotherapy, 2009, Obaldia, Nicanor et. al.
Rational dose selection for a nonnucleoside reverse transcriptase inhibitor through use of population pharmacokinetic modeling and Monte Carlo simulation.
score: 1.1431719, Antimicrobial agents and chemotherapy, 2002, Drusano, G L; Moore, K H P; Kleim, J P; Prince, W; Bye, A
In vitro and in vivo antimalarial activities of T-2307, a novel arylamidine.
score: 1.1431575, Antimicrobial agents and chemotherapy, 2012, Kimura, Akiko et. al.
Bactericidal activity of multiple combinations of tigecycline and colistin against NDM-1-producing Enterobacteriaceae.
score: 1.1431351, Antimicrobial agents and chemotherapy, 2012, Albur, Mahableshwar et. al.
Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.
score: 1.1431011, Antimicrobial agents and chemotherapy, 2004, Pang, Xiuhua et. al.
Population pharmacokinetics of linezolid in patients treated in a compassionate-use program.
score: 1.1430753, Antimicrobial agents and chemotherapy, 2003, Meagher, Alison K et. al.
Antistaphylococcal activities of telavancin tested alone and in combination by time-kill assay.
score: 1.143065, Antimicrobial agents and chemotherapy, 2010, Lin, Gengrong et. al.
Rapid screening technique for class 1 integrons in Enterobacteriaceae and nonfermenting gram-negative bacteria and its use in molecular epidemiology.
score: 1.1430519, Antimicrobial agents and chemotherapy, 2001, Maguire, A J; Brown, D F; Gray, J J; Desselberger, U
Polyether ionophores—promising bioactive molecules for cancer therapy
score: 1.1430309, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam
Polyether ionophores—promising bioactive molecules for cancer therapy
score: 1.1430309, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam
Polyether ionophores—promising bioactive molecules for cancer therapy
score: 1.1430309, Bioorganic & Medicinal Chemistry Letters, 2012, Huczyński, Adam
Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9- O-acetylsialic acid esterase from influenza C virus
score: 1.1429895, Bioorganic & Medicinal Chemistry, 1996, Fitz, Wolfgang; Rosenthal, Peter B.; Wong, Chi-Huey
Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.
score: 1.1429303, Antimicrobial agents and chemotherapy, 2003, Young, Laura Y; Hull, Christina M; Heitman, Joseph
Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases
score: 1.1429053, Bioorganic & Medicinal Chemistry Letters, 2002, Ulrich, Scott M; Sallee, Nathan A; Shokat, Kevan M
Accessible 5′-end of CpG-containing Phosphorothioate Oligodeoxynucleotides is essential for immunostimulatory activity
score: 1.1427894, Bioorganic & Medicinal Chemistry Letters, 2000, Yu, Dong et. al.
Structure–affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol
score: 1.1427025, Bioorganic & Medicinal Chemistry, 2005, Aepkers, Marion; Wünsch, Bernhard
Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus.
score: 1.1426741, Antimicrobial agents and chemotherapy, 2008, Mesak, Lili Rosana; Miao, Vivian; Davies, Julian
In vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus species.
score: 1.1426088, Antimicrobial agents and chemotherapy, 2001, Jalava, J; Kataja, J; Seppälä, H; Huovinen, P
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist
score: 1.1425339, Bioorganic & Medicinal Chemistry, 2006, Trapella, Claudio et. al.
Preliminary in vivo evaluation of a novel 99mTc-Labeled HYNIC- cys-annexin A5 as an apoptosis imaging agent
score: 1.1425332, Bioorganic & Medicinal Chemistry Letters, 2008, Fonge, Humphrey et. al.
Molecular basis for different levels of tet(M) expression in Streptococcus pneumoniae clinical isolates.
score: 1.1424183, Antimicrobial agents and chemotherapy, 2012, Grohs, Patrick et. al.
Multi-target spectral moments for QSAR and Complex Networks study of antibacterial drugs
score: 1.1423728, European Journal of Medicinal Chemistry, 2009, Prado-Prado, Francisco J. et. al.
Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages
score: 1.1423289, Bioorganic & Medicinal Chemistry Letters, 2013, Jun, Hee-jin et. al.
Relationship between capsular type, penicillin susceptibility, and virulence of human Streptococcus pneumoniae isolates in mice.
score: 1.1423285, Antimicrobial agents and chemotherapy, 2000, Azoulay-Dupuis, E et. al.
Process analysis of variables for standardization of antifungal susceptibility testing of nonfermentative yeasts.
score: 1.1422925, Antimicrobial agents and chemotherapy, 2011, Zaragoza, Oscar et. al.
Tra1 as a screening target for transcriptional activation domain discovery
score: 1.1422609, Bioorganic & Medicinal Chemistry Letters, 2009, Majmudar, Chinmay Y.; Labut, Anne E.; Mapp, Anna K.
Association of fluconazole pharmacodynamics with mortality in patients with candidemia.
score: 1.142253, Antimicrobial agents and chemotherapy, 2009, Arendrup, Maiken C et. al.
Stereoselective synthesis of a conformationally defined cyclohexyl carnitine analogue that binds CPT-1 with high affinity
score: 1.1422481, Bioorganic & Medicinal Chemistry, 1999, Hutchison, Tracy L. et. al.
Synthesis and antiinflammatory activity of heterocyclic indole derivatives
score: 1.142206, European Journal of Medicinal Chemistry, 2004, Rani, Preeti; Srivastava, V.K.; Kumar, Ashok
Improving the Solubility of a New Class of Antiinflammatory Pharmacodynamic Hybrids, that Release Nitric Oxide and Inhibit Cycloxygenase-2 Isoenzyme
score: 1.1421713, European Journal of Medicinal Chemistry, 2012, Biava, Mariangela et. al.
Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole.
score: 1.1421123, Antimicrobial agents and chemotherapy, 2004, Afeltra, Javier et. al.
Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms.
score: 1.1420953, Antimicrobial agents and chemotherapy, 1999, Heaton, V J; Goldsmith, C E; Ambler, J E; Fisher, L M
In vitro antimicrobial activity of doripenem, a new carbapenem.
score: 1.1420505, Antimicrobial agents and chemotherapy, 2004, Ge, Yigong et. al.
Activities of two novel macrolides, GW 773546 and GW 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against Haemophilus influenzae.
score: 1.1420283, Antimicrobial agents and chemotherapy, 2004, Kosowska, Klaudia et. al.
In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues.
score: 1.1420236, Antimicrobial agents and chemotherapy, 1999, Yoshimura, K et. al.
Predominance of 23S rRNA mutants among non-erm, non-mef macrolide-resistant clinical isolates of Streptococcus pneumoniae collected in the United States in 1999-2000.
score: 1.1419032, Antimicrobial agents and chemotherapy, 2005, Davies, Todd A; Bush, Karen; Sahm, Daniel; Evangelista, Alan
Synthesis of nucleoside 5′-boranophosphorothioate derivatives using an H-boranophosphonate monoester as a precursor
score: 1.1418475, Bioorganic & Medicinal Chemistry Letters, 2012, Oka, Natsuhisa; Takayama, Yuji; Ando, Kaori; Wada, Takeshi
Probing the phytopathogenic stem rot fungus with phytoalexins and analogues: unprecedented glucosylation of camalexin and 6-methoxycamalexin
score: 1.1418197, Bioorganic & Medicinal Chemistry, 2002, Pedras, M.Soledade C; Ahiahonu, Pearson W.K
Effects of azithromycin on shiga toxin production by Escherichia coli and subsequent host inflammatory response.
score: 1.1418179, Antimicrobial agents and chemotherapy, 2002, Ohara, Tatsuki et. al.
Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: Synthesis, spectral, antimicrobial, and DNA interaction approach
score: 1.1417548, Bioorganic & Medicinal Chemistry Letters, 2008, Patel, M.N.; Patel, S.H.; Chhasatia, M.R.; Parmar, P.A.
Long-term follow-up trial of oral rifampin-cotrimoxazole combination versus intravenous cloxacillin in treatment of chronic staphylococcal osteomyelitis.
score: 1.1417409, Antimicrobial agents and chemotherapy, 2009, Euba, G et. al.
Effects of linking 15-zinc finger domains on DNA binding specificity and multiple DNA binding modes
score: 1.1417336, Bioorganic & Medicinal Chemistry Letters, 2005, Hirata, Tsuyoshi et. al.
Evaluation of the Novel Combination of High-Dose Daptomycin plus Trimethoprim-Sulfamethoxazole against Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Using an In Vitro Pharmacokinetic/Pharmacodynamic Model of Simulated Endocardial Vegetations.
score: 1.1416938, Antimicrobial agents and chemotherapy, 2012, Steed, Molly E et. al.
QSAR study on CA inhibitory activity of disulfonamides: effect of halogen substitution
score: 1.1416338, Bioorganic & Medicinal Chemistry, 2004, Jaiswal, Mona; Khadikar, Padmakar V.; Supuran, Claudiu T.
Mild and efficient oxidation of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by a new polystyrene-bound Mn(TPP)Cl
score: 1.1416053, Bioorganic & Medicinal Chemistry Letters, 2006, Moghadam, Majid et. al.
Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
score: 1.1415969, European Journal of Medicinal Chemistry, 2000, Biot, Christophe et. al.
Identification and characterization of the penicillin-binding protein 2a of Streptococcus pneumoniae and its possible role in resistance to beta-lactam antibiotics.
score: 1.1413479, Antimicrobial agents and chemotherapy, 2000, Zhao, G; Meier, T I; Hoskins, J; McAllister, K A
Binding of lectins to DNA micro-assemblies: Modification of nucleo-cages with lactose-conjugated psoralen
score: 1.1412067, Bioorganic & Medicinal Chemistry, 2007, Kim, Kwonil; Matsuura, Kazunori; Kimizuka, Nobuo
A diversity oriented synthesis of 3′- O-modified nucleoside triphosphates for DNA ‘sequencing by synthesis’
score: 1.1411458, Bioorganic & Medicinal Chemistry Letters, 2006, Lu, Genliang; Burgess, Kevin
Multi gram synthesis of UDP- N-acetylmuramic acid
score: 1.1411208, Bioorganic & Medicinal Chemistry Letters, 2000, Dini, C.; Drochon, N.; Ferrari, P.; Aszodi, J.
Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products
score: 1.1411206, Bioorganic & Medicinal Chemistry, 2006, Hamilton, Chris J. et. al.
Pharmacokinetic/Pharmacodynamic predictors of clinical potency for hepatitis C virus nonnucleoside polymerase and protease inhibitors.
score: 1.1411033, Antimicrobial agents and chemotherapy, 2012, Reddy, Micaela B et. al.
Antimycobacterial compounds. New pyrrole derivatives of BM212
score: 1.1410768, Bioorganic & Medicinal Chemistry, 2004, Biava, Mariangela et. al.
Increased HLA-DQ2-affinity of a synthetic gliadin peptide by acid-induced deamidation of glutamine residues
score: 1.1410729, Bioorganic & Medicinal Chemistry Letters, 1998, Terreaux, Christian et. al.
Pharmacodynamics of moxifloxacin against Streptococcus pyogenes in an in vitro kinetic model.
score: 1.1410184, Antimicrobial agents and chemotherapy, 2002, Odenholt, Inga et. al.
Horizontal transfer of the OXA-24 carbapenemase gene via outer membrane vesicles: a new mechanism of dissemination of carbapenem resistance genes in Acinetobacter baumannii.
score: 1.1409779, Antimicrobial agents and chemotherapy, 2011, Rumbo, Carlos et. al.
Double-carbapenem therapy for carbapenemase-producing Klebsiella pneumoniae.
score: 1.1408038, Antimicrobial agents and chemotherapy, 2011, Bulik, Catharine C; Nicolau, David P
Immobilized methyltrioxo rhenium (MTO)/H 2O 2 systems for the oxidation of lignin and lignin model compounds
score: 1.140748, Bioorganic & Medicinal Chemistry, 2006, Crestini, Claudia et. al.
Efficacy of posaconazole in a murine model of central nervous system aspergillosis.
score: 1.1405922, Antimicrobial agents and chemotherapy, 2004, Imai, Jackie K et. al.
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients.
score: 1.1405906, Antimicrobial agents and chemotherapy, 2005, Herzmann, C et. al.
Bactericidal action of gatifloxacin, rifampin, and isoniazid on logarithmic- and stationary-phase cultures of Mycobacterium tuberculosis.
score: 1.1405704, Antimicrobial agents and chemotherapy, 2005, Paramasivan, C N et. al.
Induction of fibronectin-binding proteins and increased adhesion of quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin.
score: 1.1402666, Antimicrobial agents and chemotherapy, 2000, Bisognano, C; Vaudaux, P; Rohner, P; Lew, D P; Hooper, D C
Comparison of Fluconazole Renal Penetration Levels in Healthy and Candida albicans-Infected Wistar Rats.
score: 1.1402192, Antimicrobial agents and chemotherapy, 2012, Azeredo, Francine Johansson et. al.
Chemical studies of the antioxidant mechanism of tea catechins: radical reaction products of epicatechin with peroxyl radicals
score: 1.140129, Bioorganic & Medicinal Chemistry, 2003, Sang, Shengmin et. al.
Synthesis of fluorescein labeled 7-methylguanosinemonophosphate
score: 1.1400251, Bioorganic & Medicinal Chemistry Letters, 2004, Natarajan, Amarnath et. al.
Escherichia coli mutators present an enhanced risk for emergence of antibiotic resistance during urinary tract infections.
score: 1.1400032, Antimicrobial agents and chemotherapy, 2004, Miller, Keith; O'Neill, Alexander John; Chopra, Ian
Effect of 2′-OH acetylation on the bioactivity and conformation of 7- O-[ N-(4′-fluoresceincarbonyl)- l-alanyl]taxol. A NMR-fluorescence microscopy study
score: 1.1398958, Bioorganic & Medicinal Chemistry, 1998, Jiménez-Barbero, Jesús et. al.
Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme.
score: 1.1398828, Antimicrobial agents and chemotherapy, 2012, Manageiro, Vera et. al.
Cell Envelope Stress Response in Cell Wall-Deficient L-Forms of Bacillus subtilis.
score: 1.1397917, Antimicrobial agents and chemotherapy, 2012, Wolf, Diana et. al.
The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model.
score: 1.1397656, Antimicrobial agents and chemotherapy, 2012, Deris, Zakuan Z et. al.
Kinetic and mechanistic studies of proline-mediated direct intermolecular aldol reactions
score: 1.1397492, Bioorganic & Medicinal Chemistry Letters, 2009, Zotova, Natalia et. al.
Activities of six different quinolones against clinical respiratory isolates of Streptococcus pneumoniae with reduced susceptibility to ciprofloxacin in Spain.
score: 1.1396727, Antimicrobial agents and chemotherapy, 2002, Pérez-Trallero, E et. al.
Structure–activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
score: 1.139662, Bioorganic & Medicinal Chemistry, 2006, Han, Chunguang; Qi, Jianhua; Ojika, Makoto
Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis.
score: 1.1394598, Antimicrobial agents and chemotherapy, 2012, Chew, Wai Kit et. al.
Design, synthesis and antibacterial activity of minor groove binders: The role of non-cationic tail groups
score: 1.1394362, European Journal of Medicinal Chemistry, 2012, Khalaf, Abedawn I. et. al.
Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class
score: 1.1393908, Bioorganic & Medicinal Chemistry, 2005, Biava, Mariangela et. al.
Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents
score: 1.1393731, Bioorganic & Medicinal Chemistry, 2006, Hamad, Mohamed O. et. al.
Antimicrobial activities of garenoxacin (BMS 284756) against Asia-Pacific region clinical isolates from the SENTRY program, 1999 to 2001.
score: 1.1393173, Antimicrobial agents and chemotherapy, 2004, Christiansen, K J; Bell, J M; Turnidge, J D; Jones, R N
N- p-Nitrobenzyloxycarbonyl galactosamine imidate as a glycosyl donor for the efficient synthesis of mucin core-2 analogue
score: 1.1391989, Bioorganic & Medicinal Chemistry Letters, 2000, Liao, Wensheng et. al.
A kit method for the high level synthesis of [ 211At]MABG
score: 1.1391021, Bioorganic & Medicinal Chemistry, 2007, Vaidyanathan, Ganesan et. al.
Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X
score: 1.1390089, European Journal of Medicinal Chemistry, 2001, Badawneh, Muwaffag et. al.
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
score: 1.1389803, Antimicrobial agents and chemotherapy, 2011, Krizova, Lenka; Dijkshoorn, Lenie; Nemec, Alexandr
Synthesis and antiviral activity of a new series of 4-isothiazolecarbonitriles
score: 1.1389282, Bioorganic & Medicinal Chemistry, 1998, Cutrí, Christian C.C. et. al.
New insertion sequence elements in the upstream region of cfiA in imipenem-resistant Bacteroides fragilis strains.
score: 1.1388729, Antimicrobial agents and chemotherapy, 2003, Kato, Naoki et. al.
Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells
score: 1.138761, Bioorganic & Medicinal Chemistry, 2005, Park, Jin; Li, Qian; Chang, Young-Tae; Kim, Tae Sung
Multidrug resistance of a porin deletion mutant of Mycobacterium smegmatis.
score: 1.1387376, Antimicrobial agents and chemotherapy, 2004, Stephan, Joachim et. al.
Structure–activity relationship and conformational analysis of monoglycosylceramides on the syngeneic mixed leukocyte reaction
score: 1.1386981, Bioorganic & Medicinal Chemistry, 1998, Iijima, Hiroshi et. al.
Iridoid Glucosides and a C13−Norisoprenoid from Lamiophlomis rotata and their effects on NF-κB activation
score: 1.1385831, Bioorganic & Medicinal Chemistry Letters, 2012, Zhang, Feng et. al.
Serum and cerebrospinal fluid concentrations of linezolid in neurosurgical patients.
score: 1.1384413, Antimicrobial agents and chemotherapy, 2006, Myrianthefs, Pavlos et. al.
In vitro activities of faropenem against 579 strains of anaerobic bacteria.
score: 1.1383853, Antimicrobial agents and chemotherapy, 2002, Wexler, Hannah M et. al.
dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.
score: 1.1383548, Antimicrobial agents and chemotherapy, 2005, Kehrenberg, Corinna; Schwarz, Stefan
National surveillance of methicillin-resistant Staphylococcus aureus in Belgian hospitals indicates rapid diversification of epidemic clones.
score: 1.1383166, Antimicrobial agents and chemotherapy, 2004, Denis, Olivier et. al.
Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii.
score: 1.1383049, Antimicrobial agents and chemotherapy, 2000, Kaneshiro, E S; Collins, M S; Cushion, M T
β-Lactam-based approach for the chemical programming of aldolase antibody 38C2
score: 1.1383002, Bioorganic & Medicinal Chemistry Letters, 2009, Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas, Carlos F.
Comparative bactericidal activities of daptomycin and vancomycin against glycopeptide-intermediate Staphylococcus aureus (GISA) and heterogeneous GISA isolates.
score: 1.1382577, Antimicrobial agents and chemotherapy, 2006, Wootton, Mandy; MacGowan, Alasdair P; Walsh, Timothy R
Synthesis and β-lactamase inhibitory activity of new 6β-cysteinesulfonamidopenicillanic acids
score: 1.1382213, Bioorganic & Medicinal Chemistry, 1999, Changov, Lubomir S. et. al.
Acidic and basic deprotection strategies of borane-protected phosphinothioesters for the traceless Staudinger ligation
score: 1.1381606, Bioorganic & Medicinal Chemistry, 2010, Mühlberg, Michaela et. al.
Structural change of the enterobactin synthetase in crowded solution and its relation to crowding-enhanced product specificity in nonribosomal enterobactin biosynthesis
score: 1.1381436, Bioorganic & Medicinal Chemistry Letters, 2010, Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong
Synthesis and in vitro antitumor effect of diclofenac and fenoprofen thiolated and nonthiolated polyaspartamide-drug conjugates
score: 1.1381212, European Journal of Medicinal Chemistry, 2007, Barbarić, M. et. al.
Use of 2-( tert-butyldiphenylsilyloxymethyl) benzoyl as N-protecting group for the synthesis of prooligonucleotides
score: 1.1380352, Bioorganic & Medicinal Chemistry Letters, 2001, Guerlavais, Typhaine et. al.
An elevated mutation frequency favors development of vancomycin resistance in Staphylococcus aureus.
score: 1.1379844, Antimicrobial agents and chemotherapy, 2002, Schaaff, Franziska; Reipert, Andrea; Bierbaum, Gabriele
Antifungal properties and target evaluation of three putative bacterial histidine kinase inhibitors.
score: 1.137982, Antimicrobial agents and chemotherapy, 1999, Deschenes, R J; Lin, H; Ault, A D; Fassler, J S
Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae.
score: 1.137873, Antimicrobial agents and chemotherapy, 2001, Conrath, K E et. al.
Maternal-fetal pharmacokinetics and dynamics of a single intrapartum dose of maraviroc in rhesus macaques.
score: 1.1378394, Antimicrobial agents and chemotherapy, 2010, Winters, Mark A et. al.
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.
score: 1.1378196, Antimicrobial agents and chemotherapy, 2000, Poirel, L et. al.
Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides
score: 1.1377356, Bioorganic & Medicinal Chemistry, 2001, Bremer, Ryan E et. al.
Dimeric sesquiterpene thioalkaloids with potent immunosuppressive activity from the rhizome of Nuphar pumilum
score: 1.1376977, Bioorganic & Medicinal Chemistry, 2001, Matsuda, Hisashi; Shimoda, Hiroshi; Yoshikawa, Masayuki
Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem.
score: 1.1376887, Antimicrobial agents and chemotherapy, 2004, Pachón-Ibáñez, María Eugenia et. al.
Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy
score: 1.1376516, Bioorganic & Medicinal Chemistry, 2002, Kotha, Sambasivarao; Brahmachary, Enugurthi
Optimization of the enzymatic synthesis of O-glycan core 2 structure by use of a genetic algorithm
score: 1.1375538, Bioorganic & Medicinal Chemistry Letters, 2002, Hoh, Christoph; Dudziak, Gregor; Liese, Andreas
Plasmodium vivax resistance to chloroquine in Madagascar: clinical efficacy and polymorphisms in pvmdr1 and pvcrt-o genes.
score: 1.1374151, Antimicrobial agents and chemotherapy, 2008, Barnadas, Céline et. al.
Antifungal Susceptibilities of Aspergillus fumigatus Clinical Isolates Obtained in Nagasaki, Japan.
score: 1.1374041, Antimicrobial agents and chemotherapy, 2012, Tashiro, Masato et. al.
Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones.
score: 1.1373801, Antimicrobial agents and chemotherapy, 1999, Pan, X S; Fisher, L M
An amphiphilic fluorescent probe for the visualization of histamine in living cells
score: 1.1373001, Bioorganic & Medicinal Chemistry Letters, 2010, Seto, Daisuke; Soh, Nobuaki; Nakano, Koji; Imato, Toshihiko
Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2.
score: 1.1372896, Antimicrobial agents and chemotherapy, 2012, Hull, Claire M et. al.
Purification and biochemical characterization of the VIM-1 metallo-beta-lactamase.
score: 1.1371929, Antimicrobial agents and chemotherapy, 2000, Franceschini, N et. al.
Integron-located oxa-32 gene cassette encoding an extended-spectrum variant of OXA-2 beta-lactamase from Pseudomonas aeruginosa.
score: 1.1371207, Antimicrobial agents and chemotherapy, 2002, Poirel, Laurent et. al.
Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: Synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-β- d-glucopyranosyl derivatives of N 4-benzoyl cytosine
score: 1.137099, European Journal of Medicinal Chemistry, 2009, Manta, Stella et. al.
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: study of antibiotic combinations.
score: 1.1368413, Antimicrobial agents and chemotherapy, 2009, Nguyen, Hoang Anh et. al.
Aptazyme-based riboswitches as label-free and detector-free sensors for cofactors
score: 1.1367756, Bioorganic & Medicinal Chemistry Letters, 2007, Ogawa, Atsushi; Maeda, Mizuo
Role of the MexEF-OprN Efflux System in Low-Level Resistance of Pseudomonas aeruginosa to Ciprofloxacin.
score: 1.1366795, Antimicrobial agents and chemotherapy, 2011, Llanes, Catherine et. al.
Chitooligosaccharides induce apoptosis in human myeloid leukemia HL-60 cells
score: 1.1366628, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Eun-Kyung et. al.
A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines
score: 1.1366245, Bioorganic & Medicinal Chemistry, 2006, Elwell, Kyler E. et. al.
1,3-Disubstituted benzazepines as neuropeptide Y Y1 receptor antagonists
score: 1.1366152, Bioorganic & Medicinal Chemistry, 1999, Murakami, Yasushi et. al.
Allyl and benzyl iodides by the anomalous action of iodotrimethylsilane
score: 1.1365802, Bioorganic & Medicinal Chemistry Letters, 2006, Zhu, Qing; Tremblay, Matthew S.
Remarkably enhanced inhibitory effects of hybrid liposomes on the growth of specific tumor cells
score: 1.1365655, Bioorganic & Medicinal Chemistry Letters, 1999, Matsumoto, Yoko et. al.
Design, solid phase synthesis and evaluation of cationic ferrocenoyl peptide bioconjugates as potential antioxidant enzyme mimics
score: 1.1365354, Bioorganic & Medicinal Chemistry Letters, 2009, Soulère, Laurent; Bernard, Julien
Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities
score: 1.1365104, Bioorganic & Medicinal Chemistry Letters, 2005, Mishra, Pushpesh Kumar et. al.
Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.
score: 1.1364367, Antimicrobial agents and chemotherapy, 2002, Siddiqi, Noman et. al.
NaBH 4 in N-methylpyrrolidone: a safe alternative for hydride displacement reaction
score: 1.1363313, Bioorganic & Medicinal Chemistry Letters, 2001, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Pharmacodynamic assessment of ertapenem (MK-0826) against Streptococcus pneumoniae in a murine neutropenic thigh infection model.
score: 1.1363283, Antimicrobial agents and chemotherapy, 2002, Xuan, Dawei et. al.
N-confused porphyrin possessing glucamine-appendants: Aggregation and acid/base properties in aqueous media
score: 1.1362333, Bioorganic & Medicinal Chemistry Letters, 2008, Ikawa, Yoshiya et. al.
α-Galactose based neoglycopeptides. Inhibition of verotoxin binding to globotriosylceramide
score: 1.1362206, Bioorganic & Medicinal Chemistry, 1999, Arya, Prabhat et. al.
Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) modified oligonucleotides containing neutral urea linkages: effect of charge deletions on binding and fidelity
score: 1.1362034, Bioorganic & Medicinal Chemistry, 2000, Linkletter, Barry A.; Bruice, Thomas C.
Association studies of aggregated aqueous lutein diphosphate with human serum albumin and α 1-acid glycoprotein in vitro: Evidence from circular dichroism and electronic absorption spectroscopy
score: 1.1361049, Bioorganic & Medicinal Chemistry Letters, 2006, Zsila, Ferenc; Nadolski, Geoff; Lockwood, Samuel F.
A general synthesis of specifically deuterated nucleotides for studies of DNA and RNA
score: 1.1360619, Bioorganic & Medicinal Chemistry Letters, 2002, Chen, Bingzi; Jamieson, Elizabeth R.; Tullius, Thomas D.
Emergence of fluoroquinolone resistance in strains of Vibrio cholerae isolated from hospitalized patients with acute diarrhea in Calcutta, India.
score: 1.1360544, Antimicrobial agents and chemotherapy, 1998, Mukhopadhyay, A K et. al.
Antiamoebic and toxicity studies of a carbamic acid derivative and its therapeutic effect in a hamster model of hepatic amoebiasis.
score: 1.1360252, Antimicrobial agents and chemotherapy, 2005, Ordaz-Pichardo, Cynthia et. al.
Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.
score: 1.1359954, Antimicrobial agents and chemotherapy, 2005, Komiyama, Tomoko; Swanson, Joel A; Fuller, Robert S
MK-0536 inhibits HIV-1 integrases resistant to raltegravir.
score: 1.1359749, Antimicrobial agents and chemotherapy, 2011, Métifiot, Mathieu et. al.
Glucose–aspirin: Synthesis and in vitro anti-cancer activity studies
score: 1.1359622, Bioorganic & Medicinal Chemistry Letters, 2012, Jacob, James N.; Tazawa, Makio J.
Efficacy of CS-834 against experimental pneumonia caused by penicillin-susceptible and -resistant Streptococcus pneumoniae in mice.
score: 1.1358546, Antimicrobial agents and chemotherapy, 1998, Fukuoka, T et. al.
Aspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole.
score: 1.1357894, Antimicrobial agents and chemotherapy, 2011, Escribano, Pilar et. al.
Assessing the chemical diversity of an hsp90 database
score: 1.1357812, European Journal of Medicinal Chemistry, 2010, Audisio, Davide et. al.
Design and synthesis of a novel enediynyl pentapeptide with predominantly β-turn structural motif and its potential as a fluorescence-based chemosensor
score: 1.1357068, Bioorganic & Medicinal Chemistry, 2005, Basak, Amit; Bag, Subhendu Sekhar; Basak, Ajoy
Hybrid liposomes inhibit the growth of Cholangiocarcinoma by induction of cell cycle arrest in G 1 phase
score: 1.1356756, Bioorganic & Medicinal Chemistry Letters, 2010, Towata, Tomomi et. al.
In vitro activities of new antimicrobials against Nocardia brasiliensis.
score: 1.1356448, Antimicrobial agents and chemotherapy, 2004, Vera-Cabrera, Lucio et. al.
Lack of evidence for in vivo transformation of zidovudine triphosphate to stavudine triphosphate in human immunodeficiency virus-infected patients.
score: 1.1355623, Antimicrobial agents and chemotherapy, 2006, Meléndez, Margarita et. al.
4-Thio-5-bromo-2′-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damage
score: 1.1352985, Bioorganic & Medicinal Chemistry Letters, 2004, Xu, Yao-Zhong et. al.
Boronic acid fluorescent sensors for monosaccharide signaling based on the 6-methoxyquinolinium heterocyclic nucleus: progress toward noninvasive and continuous glucose monitoring
score: 1.135239, Bioorganic & Medicinal Chemistry, 2005, Badugu, Ramachandram; Lakowicz, Joseph R.; Geddes, Chris D.
PNA/DNA interstrand cross-links from a modified PNA base upon photolysis or oxidative conditions
score: 1.1351968, Bioorganic & Medicinal Chemistry Letters, 2008, Kim, Yongtae; Hong, In Seok
Synthesis of double-Headed 2-5A-Antisense chimeras and Their ability to activate human RNase L
score: 1.1351482, Bioorganic & Medicinal Chemistry Letters, 2003, Ueno, Yoshihito et. al.
Heme binding contributes to antimalarial activity of bis-quaternary ammoniums.
score: 1.1350783, Antimicrobial agents and chemotherapy, 2003, Biagini, Giancarlo A et. al.
Novel Cu(II) quinoxaline N 1, N 4-dioxide complexes as selective hypoxic cytotoxins
score: 1.1350349, European Journal of Medicinal Chemistry, 2005, Torre, María H. et. al.
Hydrogen bond interactions of a series of N-substituted TXA 2 receptor antagonists
score: 1.1350282, European Journal of Medicinal Chemistry, 2003, Taylor, Dawne M.; Halushka, Perry V.; Meier, G.Patrick
Synthesis and biological evaluation of a new vitamin D2 analogue
score: 1.1349819, Bioorganic & Medicinal Chemistry Letters, 2012, Gándara, Zoila et. al.
Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues
score: 1.1349726, Bioorganic & Medicinal Chemistry, 2000, Singh, Sheo B. et. al.
Influences of urinary pH on ciprofloxacin pharmacokinetics in humans and antimicrobial activity in vitro versus those of sparfloxacin.
score: 1.1349455, Antimicrobial agents and chemotherapy, 1999, Kamberi, M et. al.
Inhibition of filamentation can be used to treat disseminated candidiasis.
score: 1.1349228, Antimicrobial agents and chemotherapy, 2006, Saville, Stephen P et. al.
Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.
score: 1.1349175, Antimicrobial agents and chemotherapy, 2009, Swenson, Dana L et. al.
Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance.
score: 1.1349102, Antimicrobial agents and chemotherapy, 2004, Ahmed, Anwar et. al.
Design, synthesis, and anti-tumor activity of (2- O-alkyloxime-3-phenyl)-propionyl-1- O-acetylbritannilactone esters
score: 1.1348784, Bioorganic & Medicinal Chemistry, 2005, Liu, Shouxin et. al.
In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species.
score: 1.1348521, Antimicrobial agents and chemotherapy, 2012, Wittlin, Sergio et. al.
Mycobacterium tuberculosis and sulfamethoxazole susceptibility.
score: 1.1347246, Antimicrobial agents and chemotherapy, 2010, Ong, Wendy; Sievers, Aina; Leslie, David E
Synthesis and investigation of antimicrobial activity of some bisbenzimidazole-derived chelating agents
score: 1.1346739, European Journal of Medicinal Chemistry, 2003, Agh-Atabay, Naz M; Dulger, Basaran; Gucin, Fahrettin
In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus.
score: 1.1346514, Antimicrobial agents and chemotherapy, 2008, Banerjee, Ritu et. al.
Prediction of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas based on the heuristic method, support vector machine and projection pursuit regression
score: 1.1346458, European Journal of Medicinal Chemistry, 2009, Yuan, Yongna; Zhang, Ruisheng; Hu, Rongjing; Ruan, Xiaofang
Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital.
score: 1.1345667, Antimicrobial agents and chemotherapy, 2000, Chanal, C et. al.
In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis.
score: 1.1344866, Antimicrobial agents and chemotherapy, 2006, Cuenca-Estrella, Manuel et. al.
Polyamines induce resistance to cationic peptide, aminoglycoside, and quinolone antibiotics in Pseudomonas aeruginosa PAO1.
score: 1.1344796, Antimicrobial agents and chemotherapy, 2006, Kwon, Dong H; Lu, Chung-Dar
Flow cytometric screening of aldolase catalytic antibodies
score: 1.1344525, Bioorganic & Medicinal Chemistry Letters, 2004, Shim, Hyunbo et. al.
Acquired macrolide resistance genes in pathogenic Neisseria spp. isolated between 1940 and 1987.
score: 1.1344253, Antimicrobial agents and chemotherapy, 2003, Cousin, Sydney; Whittington, William L H; Roberts, Marilyn C
Genetic diversity of the tet(M) gene in tetracycline-resistant clonal lineages of Streptococcus pneumoniae.
score: 1.1343997, Antimicrobial agents and chemotherapy, 2000, Doherty, N et. al.
Influence of carbon dioxide on the MIC of telithromycin for Streptococcus pneumoniae: an in vitro-in vivo study.
score: 1.1343886, Antimicrobial agents and chemotherapy, 2005, Batard, Eric et. al.
A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity
score: 1.1343832, Bioorganic & Medicinal Chemistry, 2006, Wijeratne, E.M. Kithsiri et. al.
Synthesis of the first sulfur-35-labeled hERG radioligand
score: 1.1343551, Bioorganic & Medicinal Chemistry Letters, 2006, Raab, Conrad E. et. al.
Attenuation of collagen-induced arthritis by orally available imidazoline-based NF-κB inhibitors
score: 1.1342976, Bioorganic & Medicinal Chemistry Letters, 2012, Lansdell, Theresa A. et. al.
New 14-membered octaazamacrocyclic complexes: Synthesis, spectral, antibacterial and antifungal studies
score: 1.1342949, European Journal of Medicinal Chemistry, 2010, Singh, D.P.; Kumar, Krishan; Sharma, Chetan
Biological cost of AmpC production for Salmonella enterica serotype Typhimurium.
score: 1.1342321, Antimicrobial agents and chemotherapy, 2000, Morosini, M I et. al.
Genomewide scan reveals amplification of mdr1 as a common denominator of resistance to mefloquine, lumefantrine, and artemisinin in Plasmodium chabaudi malaria parasites.
score: 1.1340799, Antimicrobial agents and chemotherapy, 2011, Borges, Sofia et. al.
Zinc(II) complexes of tripodal peptides mimicking the zinc(II)-coordination structure of carbonic anhydrase
score: 1.1339875, Bioorganic & Medicinal Chemistry, 1999, Herr, Ulrike et. al.
Synthesis of N2-modified 7-methylguanosine 5’-monophosphates as nematode translation inhibitors
score: 1.1339842, Bioorganic & Medicinal Chemistry, 2012, Piecyk, Karolina et. al.
Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid
score: 1.1338441, Bioorganic & Medicinal Chemistry, 2004, Fonseca, Tatiana et. al.
ESR studies on DNA cleavage induced by enediyne C-1027 chromophore
score: 1.1337947, Bioorganic & Medicinal Chemistry, 2005, Usuki, Toyonobu et. al.
New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities
score: 1.1337582, Bioorganic & Medicinal Chemistry, 2006, Choudhary, Muhammad Iqbal et. al.
Inhibitors of acyl-CoA:cholesterol acyltransferase: novel trisubstituted ureas as hypocholesterolemic agents
score: 1.1337261, Bioorganic & Medicinal Chemistry, 1997, Purchase, Terri S. et. al.
Emergence of resistant Klebsiella pneumoniae in the intestinal tract during successful treatment of Klebsiella pneumoniae lung infection in rats.
score: 1.1336995, Antimicrobial agents and chemotherapy, 2010, Kesteman, Anne-Sylvie et. al.
Effect of C-Ring Modifications on the Cytotoxicity of Spirostan Saponins and Related Glycosides
score: 1.1336388, Bioorganic & Medicinal Chemistry, 2012, Pérez-Labrada, Karell et. al.
Dissemination of sul3-containing elements linked to class 1 integrons with an unusual 3' conserved sequence region among Salmonella isolates.
score: 1.1336113, Antimicrobial agents and chemotherapy, 2007, Antunes, Patrícia; Machado, Jorge; Peixe, Luísa
Synthesis and Biological Evaluation of a New Class of Glycoconjugated Disulfides that Exhibit Potential Anticancer Properties
score: 1.1335784, Bioorganic & Medicinal Chemistry, 2012, Bonaccorsi, Paola et. al.
The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS.
score: 1.133502, Antimicrobial agents and chemotherapy, 2012, Fernández, Lucía et. al.
Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure.
score: 1.1334931, Antimicrobial agents and chemotherapy, 2003, Imwong, Mallika et. al.
A comparative study of quantitative structure activity relationship methods based on antitumor diarylsulfonylureas
score: 1.1334117, European Journal of Medicinal Chemistry, 2001, Park Choo, Hea-Young et. al.
Influence of inoculum size and marbofloxacin plasma exposure on the amplification of resistant subpopulations of Klebsiella pneumoniae in a rat lung infection model.
score: 1.133409, Antimicrobial agents and chemotherapy, 2009, Kesteman, Anne-Sylvie et. al.
Model studies on a synthetically facile series of N-substituted phenyl- N′-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT 2C/2B receptor antagonists
score: 1.1333388, Bioorganic & Medicinal Chemistry, 1999, Bromidge, Steven M. et. al.
In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry.
score: 1.1333119, Antimicrobial agents and chemotherapy, 2002, Kohli, Avmeet et. al.
Cinnamic acid derived oxazolinium ions as novel cytotoxic agents
score: 1.1333001, European Journal of Medicinal Chemistry, 2002, Hedvati, Lilach et. al.
Covalent polymyxin B conjugate with human immunoglobulin G as an antiendotoxin reagent.
score: 1.1332976, Antimicrobial agents and chemotherapy, 1998, Drabick, J J et. al.
Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin–GnRH-III bioconjugates
score: 1.133184, European Journal of Medicinal Chemistry, 2012, Hegedüs, Rózsa et. al.
Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin–GnRH-III bioconjugates
score: 1.133184, European Journal of Medicinal Chemistry, 2012, Hegedüs, Rózsa et. al.
An exogenous marker: A novel approach for the characterization of oxidative stress
score: 1.1331422, Bioorganic & Medicinal Chemistry, 2007, Khatib, Soliman; Musa, Ramadan; Vaya, Jacob
Global phenotype screening and transcript analysis outlines the inhibitory mode(s) of action of two amphibian-derived, alpha-helical, cationic peptides on Saccharomyces cerevisiae.
score: 1.1331351, Antimicrobial agents and chemotherapy, 2007, Morton, C Oliver et. al.
Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile.
score: 1.1329385, Antimicrobial agents and chemotherapy, 2001, Palavecino, E L et. al.
Sequential population pharmacokinetic modeling of lopinavir and ritonavir in healthy volunteers and assessment of different dosing strategies.
score: 1.1329324, Antimicrobial agents and chemotherapy, 2011, Dickinson, Laura et. al.
Photodynamic effects of isosteric water-soluble phthalocyanines on human nasopharynx KB carcinoma cells
score: 1.13292, European Journal of Medicinal Chemistry, 2010, Marino, Julieta et. al.
Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene.
score: 1.1328064, Antimicrobial agents and chemotherapy, 2004, Dugan, Jae et. al.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
score: 1.1327607, Antimicrobial agents and chemotherapy, 2003, Arpin, Corinne et. al.
Florfenicol-chloramphenicol exporter gene fexA is part of the novel transposon Tn558.
score: 1.1326738, Antimicrobial agents and chemotherapy, 2005, Kehrenberg, Corinna; Schwarz, Stefan
Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols
score: 1.1326544, Bioorganic & Medicinal Chemistry, 2012, Ugliarolo, Esteban A. et. al.
Impact of penicillin nonsusceptibility on clinical outcomes of patients with nonmeningeal Streptococcus pneumoniae bacteremia in the era of the 2008 clinical and laboratory standards institute penicillin breakpoints.
score: 1.1325785, Antimicrobial agents and chemotherapy, 2012, Choi, Seong-Ho et. al.
Bactericidal activities of two daptomycin regimens against clinical strains of glycopeptide intermediate-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and methicillin-resistant Staphylococcus aureus isolates in an in vitro pharmacodynamic model with simulated endocardial vegetations.
score: 1.1325384, Antimicrobial agents and chemotherapy, 2001, Akins, R L; Rybak, M J
Peptidyl chemosensors incorporating a fret mechanism for detection of Ni(II)
score: 1.1324934, Bioorganic & Medicinal Chemistry Letters, 1998, Pearce, Dierdre A; Walkup, Grant K; Imperiali, Barbara
Synthesis of new derivatives of 8-oxoG-Clamp for better understanding the recognition mode and improvement of selective affinity
score: 1.1324072, Bioorganic & Medicinal Chemistry, 2010, Li, Zhichun et. al.
Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA
score: 1.1323935, Bioorganic & Medicinal Chemistry, 2010, Du, Yuhao et. al.
DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides
score: 1.1323657, Bioorganic & Medicinal Chemistry Letters, 2006, Correa, Bryan J. et. al.
Anti-toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro.
score: 1.1323322, Antimicrobial agents and chemotherapy, 2000, Derouin, F; Santillana-Hayat, M
Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells
score: 1.1322146, Bioorganic & Medicinal Chemistry Letters, 2005, Maeda, Mitsuko et. al.
Synthesis of sulfur containing dihydro-pyrrolo derivatives and their biological evaluation as antioxidants
score: 1.1321553, Bioorganic & Medicinal Chemistry, 2012, Georgiou, Dimitra et. al.
A multi-component reaction to 5-cyanouracils: Synthesis and mechanistic study
score: 1.13213, Bioorganic & Medicinal Chemistry, 2006, Zhuang, Bo-Ren; Hsu, Gien-Jow; Sung, Kuangsen
Novel oxysterols activate the Hedgehog pathway and induce osteogenesis
score: 1.1320144, Bioorganic & Medicinal Chemistry Letters, 2012, Stappenbeck, Frank et. al.
Molecular modeling and dynamics studies of Shikimate Kinase from Bacillus anthracis
score: 1.1318026, Bioorganic & Medicinal Chemistry, 2008, Pauli, Ivani et. al.
Treatment with fluoroquinolones or with beta-lactam-beta-lactamase inhibitor combinations is a risk factor for isolation of extended-spectrum-beta-lactamase-producing Klebsiella species in hospitalized patients.
score: 1.1317797, Antimicrobial agents and chemotherapy, 2010, Wener, Kenneth M et. al.
Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe
score: 1.1317649, Bioorganic & Medicinal Chemistry Letters, 2012, Suganami, Akiko et. al.
Further identification of plasmid-mediated quinolone resistance determinant in Enterobacteriaceae in Turkey.
score: 1.1317036, Antimicrobial agents and chemotherapy, 2005, Nazic, Hasan; Poirel, Laurent; Nordmann, Patrice
In vitro activities of new quinolones and oxazolidinones against Actinomadura madurae.
score: 1.1316193, Antimicrobial agents and chemotherapy, 2004, Vera-Cabrera, Lucio et. al.
Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication.
score: 1.1315989, Antimicrobial agents and chemotherapy, 2002, Koszalka, George W et. al.
Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-cyclopropyl-1,2,3,6-tetrahydropyridines
score: 1.1315445, Bioorganic & Medicinal Chemistry, 1998, Franot, Christelle; Mabic, Stéphane; Castagnol Jr, Neal
Bacteria targeted by human natural antibodies using α-gal conjugated receptor-specific glycopolymers
score: 1.1314953, Bioorganic & Medicinal Chemistry, 1999, Li, Jun et. al.
Distribution of fusidic acid resistance determinants in methicillin-resistant Staphylococcus aureus.
score: 1.131494, Antimicrobial agents and chemotherapy, 2011, McLaws, F B; Larsen, A R; Skov, R L; Chopra, I; O'Neill, A J
Discriminatory detection of inhibitor-resistant beta-lactamases in Escherichia coli by single-strand conformation polymorphism-PCR.
score: 1.1314383, Antimicrobial agents and chemotherapy, 1998, Speldooren, V; Heym, B; Labia, R; Nicolas-Chanoine, M H
Synthesis of modified proanthocyanidins: easy and general introduction of a hydroxy group at C-6 of catechin; efficient synthesis of elephantorrhizol
score: 1.1314194, Bioorganic & Medicinal Chemistry Letters, 2005, Boyer, François-Didier et. al.
Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin.
score: 1.1314095, Antimicrobial agents and chemotherapy, 2002, Sakoulas, George et. al.
Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone.
score: 1.1313896, Antimicrobial agents and chemotherapy, 2011, Ohnishi, Makoto et. al.
Activities of a new oral streptogramin, XRP 2868, compared to those of other agents against Streptococcus pneumoniae and haemophilus species.
score: 1.1313379, Antimicrobial agents and chemotherapy, 2003, Pankuch, Glenn A et. al.
Fluoride enhances the activity of fungicides that destabilize cell membranes
score: 1.1312732, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Sanshu; Breaker, Ronald R.
Fluoride enhances the activity of fungicides that destabilize cell membranes
score: 1.1312732, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Sanshu; Breaker, Ronald R.
Fluoride enhances the activity of fungicides that destabilize cell membranes
score: 1.1312732, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Sanshu; Breaker, Ronald R.
A ratiometric fluorescent sensor for Zn 2+ based on internal charge transfer (ICT)
score: 1.1312412, Bioorganic & Medicinal Chemistry Letters, 2006, Mei, Yujiang; Bentley, Paul A.
Zygomycetes hyphae trigger an early, robust proinflammatory response in human polymorphonuclear neutrophils through toll-like receptor 2 induction but display relative resistance to oxidative damage.
score: 1.1312037, Antimicrobial agents and chemotherapy, 2008, Chamilos, G et. al.
Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.
score: 1.1311913, Antimicrobial agents and chemotherapy, 1999, Lauretti, L et. al.
Modulation of RNase H activity by modified DNA probes: Major groove vs minor groove effects
score: 1.1311441, Bioorganic & Medicinal Chemistry, 1997, Daniher, Andrew T. et. al.
Fluorescence polarization method to characterize macrolide-ribosome interactions.
score: 1.1311336, Antimicrobial agents and chemotherapy, 2005, Yan, Kang et. al.
Nitroxide-labeled guanine as an ESR spin probe for structural study of DNA
score: 1.1311287, Bioorganic & Medicinal Chemistry Letters, 2004, Okamoto, Akimitsu; Inasaki, Takeshi; Saito, Isao
Biological characterization of endotoxins released from antibiotic-treated Pseudomonas aeruginosa and Escherichia coli.
score: 1.1311122, Antimicrobial agents and chemotherapy, 1998, Kirikae, T et. al.
New TEM-derived extended-spectrum beta-lactamase and its genomic context in plasmids from Salmonella enterica serovar derby isolates from Uruguay.
score: 1.1309707, Antimicrobial agents and chemotherapy, 2006, Vignoli, Rafael et. al.
Studies on Quinones. Part 38: synthesis and leishmanicidal activity of sesquiterpene 1,4-Quinones
score: 1.1309364, Bioorganic & Medicinal Chemistry, 2003, Valderrama, Jaime A et. al.
Quantitative screening of EGF receptor-binding peptides by using a peptide library with multiple fluorescent amino acids as fluorescent tags
score: 1.1309336, Bioorganic & Medicinal Chemistry Letters, 2010, Kitamatsu, Mizuki et. al.
Probes for narcotic receptor mediated phenomena. 46.o N-Substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide bridged phenylmorphans
score: 1.1309102, European Journal of Medicinal Chemistry, 2012, Li, Fuying et. al.
Novel bifunctional inhibitor of xylanase and aspartic protease: implications for inhibition of fungal growth.
score: 1.1308922, Antimicrobial agents and chemotherapy, 2001, Dash, C; Ahmad, A; Nath, D; Rao, M
Synthesis and biological evaluation of nonpeptide mimetics of ω-conotoxin GVIA
score: 1.1306763, Bioorganic & Medicinal Chemistry, 2004, Baell, Jonathan B et. al.
Inhibitors of phosphopantetheine adenylyltransferase
score: 1.1305689, European Journal of Medicinal Chemistry, 2003, Zhao, Lihua et. al.
Solid-phase synthesis of CD52 glycopeptide and an efficient route to Asn-core pentasaccharide conjugate
score: 1.1305467, Bioorganic & Medicinal Chemistry, 1997, Guo, Zhong-Wu et. al.
Antimicrobial susceptibilities of commonly encountered bacterial isolates to fosfomycin determined by agar dilution and disk diffusion methods.
score: 1.1305213, Antimicrobial agents and chemotherapy, 2011, Lu, Ching-Lan et. al.
Molecular and kinetic comparison of the novel extended-spectrum beta-lactamases CTX-M-25 and CTX-M-26.
score: 1.1304895, Antimicrobial agents and chemotherapy, 2004, Munday, Craig J et. al.
Synthesis and anticonvulsant activity of some potential thiazolidinonyl 2-oxo/thiobarbituric acids
score: 1.1304469, European Journal of Medicinal Chemistry, 2006, Agarwal, A. et. al.
Papillomavirus microbicidal activities of high-molecular-weight cellulose sulfate, dextran sulfate, and polystyrene sulfonate.
score: 1.1304244, Antimicrobial agents and chemotherapy, 2001, Christensen, N D et. al.
Antioxidant activity of β-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species?
score: 1.1304065, Bioorganic & Medicinal Chemistry, 2006, Gomes, Ana et. al.
In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection.
score: 1.130357, Antimicrobial agents and chemotherapy, 2006, Gu, Z et. al.
Dissemination of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Paris, France.
score: 1.1303385, Antimicrobial agents and chemotherapy, 2004, Eckert, C et. al.
Synthesis and biological activity of N-methylated analogs of endomorphin-2
score: 1.1303005, Bioorganic & Medicinal Chemistry, 2005, Kruszynski, Rafal et. al.
Ferrocene labelings as inhibitors and dual electrochemical sensors of human glutathione S-transferase P1-1
score: 1.1302267, Bioorganic & Medicinal Chemistry Letters, 2012, Martos-Maldonado, Manuel C. et. al.
Ferrocene labelings as inhibitors and dual electrochemical sensors of human glutathione S-transferase P1-1
score: 1.1302267, Bioorganic & Medicinal Chemistry Letters, 2012, Martos-Maldonado, Manuel C. et. al.
Ferrocene labelings as inhibitors and dual electrochemical sensors of human glutathione S-transferase P1-1
score: 1.1302267, Bioorganic & Medicinal Chemistry Letters, 2012, Martos-Maldonado, Manuel C. et. al.
Azanonaboranes [(RNH 2)B 8H 11NHR] as possible new compounds for use in boron neutron capture therapy
score: 1.1301166, European Journal of Medicinal Chemistry, 2002, Bauer, Claudia; Gabel, Detlef; Dörfler, Udo
Comparative In vitro activities of ertapenem (MK-0826) against 1,001 anaerobes isolated from human intra-abdominal infections.
score: 1.1300983, Antimicrobial agents and chemotherapy, 2000, Goldstein, E J et. al.
Double-stranded oligonucleotides containing 5-aminomethyl-2′-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA
score: 1.130052, Bioorganic & Medicinal Chemistry Letters, 2012, Shibata, Aya et. al.
Posaconazole and amphotericin B combination therapy against Cryptococcus neoformans infection.
score: 1.1300189, Antimicrobial agents and chemotherapy, 2004, Barchiesi, Francesco et. al.
Synthesis and preliminary biological assessments of RGD bearing biocompatible telomers
score: 1.1299712, Bioorganic & Medicinal Chemistry Letters, 2002, Jasseron, Sylvain et. al.
Use of drug effect interaction modeling with Monte Carlo simulation to examine the impact of dosing interval on the projected antiviral activity of the combination of abacavir and amprenavir.
score: 1.1299152, Antimicrobial agents and chemotherapy, 2000, Drusano, G L et. al.
Zinc Pyrithione Inhibits Yeast Growth through Copper Influx and Inactivation of Iron-Sulfur Proteins.
score: 1.1298804, Antimicrobial agents and chemotherapy, 2011, Reeder, Nancy L et. al.
Activity of gemifloxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.
score: 1.1298803, Antimicrobial agents and chemotherapy, 2005, Azoulay-Dupuis, E et. al.
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola
score: 1.1298305, Bioorganic & Medicinal Chemistry, 2003, Jung, Hye Jin et. al.
Characterization of Isolates from an Outbreak of Multidrug-Resistant, Shiga Toxin-Producing Escherichia coli O145 in the United States.
score: 1.1297694, Antimicrobial agents and chemotherapy, 2011, Folster, Jason P; Pecic, Gary; Taylor, Ethel; Whichard, Jean
Cell-based fluorescence assay for human immunodeficiency virus type 1 protease activity.
score: 1.1297483, Antimicrobial agents and chemotherapy, 2001, Lindsten, K et. al.
Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection.
score: 1.1297359, Antimicrobial agents and chemotherapy, 2003, Kadurugamuwa, Jagath L et. al.
Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential
score: 1.12973, Bioorganic & Medicinal Chemistry, 2005, Gunnarsson, Gunnar T. et. al.
Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities.
score: 1.1296092, Antimicrobial agents and chemotherapy, 2005, Grgurina, Ingeborg et. al.
Different protein-binding selectivities for N-acyl heparin derivatives having N-phenylacetyl and heterocycle analogs of N-phenylacetyl substituted in place of N-sulfo groups
score: 1.1295924, Bioorganic & Medicinal Chemistry Letters, 2007, Huang, Liusheng; Fernández, Cristina; Kerns, Robert J.
QSAR study on phenolic activity: need of positive hydrophobic term (log P) in QSAR
score: 1.1295498, Bioorganic & Medicinal Chemistry, 2004, Thakur, Mamta et. al.
Evaluation of hesperetin 7- O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats
score: 1.1295295, Bioorganic & Medicinal Chemistry, 2004, Choi, Gab-Sun et. al.
Construction of a ‘turn-on’ fluorescent probe system for His-tagged proteins
score: 1.1295231, Bioorganic & Medicinal Chemistry Letters, 2010, Murata, Atsushi et. al.
DNA methylase activity as a marker for the presence of a family of phage-like elements conferring efflux-mediated macrolide resistance in streptococci.
score: 1.1294921, Antimicrobial agents and chemotherapy, 2006, Figueiredo, T A; Aguiar, S I; Melo-Cristino, J; Ramirez, M
3′-Azidoabscisic acid as a photoaffinity reagent for abscisic acid binding proteins
score: 1.1294913, Bioorganic & Medicinal Chemistry Letters, 2001, Todoroki, Yasushi et. al.
N-Methylpyridoxamine: Novel canine vitamin B 6 urine metabolite
score: 1.1294782, Bioorganic & Medicinal Chemistry Letters, 2008, Ericson, Karen L. et. al.
Pharmacodynamics and bactericidal activity of moxifloxacin in experimental Escherichia coli meningitis.
score: 1.1293247, Antimicrobial agents and chemotherapy, 2001, Rodriguez-Cerrato, V et. al.
In vitro activities of tigecycline (GAR-936) against recently isolated clinical bacteria in Spain.
score: 1.1292329, Antimicrobial agents and chemotherapy, 2002, Betriu, Carmen et. al.
In vitro stability of α-Helical peptide nucleic acids (αPNAs)
score: 1.1292307, Bioorganic & Medicinal Chemistry Letters, 2001, Garner, Philip et. al.
A triazine dye, cibacron blue F3GA, decreases oxacillin resistance levels in methicillin-resistant Staphylococcus aureus.
score: 1.1292289, Antimicrobial agents and chemotherapy, 1998, Shirai, C et. al.
Spatial and temporal patterns of biocide action against Staphylococcus epidermidis biofilms.
score: 1.129219, Antimicrobial agents and chemotherapy, 2010, Davison, William M; Pitts, Betsey; Stewart, Philip S
Synthesis of a high-affinity Fluorescent PPARγ ligand for high-throughput fluorescence polarization assays
score: 1.129146, Bioorganic & Medicinal Chemistry, 2003, DeGrazia, Michael J et. al.
Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans.
score: 1.1291411, Antimicrobial agents and chemotherapy, 2006, Bowman, J C et. al.
Indinavir, efavirenz, and abacavir pharmacokinetics in human immunodeficiency virus-infected subjects.
score: 1.1291394, Antimicrobial agents and chemotherapy, 2003, DiCenzo, Robert et. al.
Solid phase synthesis of novel asymmetric hydrophilic head cholesterol-based cationic lipids with potential DNA delivery
score: 1.1291056, Bioorganic & Medicinal Chemistry, 2010, Radchatawedchakoon, Widchaya et. al.
Effect of Maraviroc on HIV Disease Progression-Related Biomarkers.
score: 1.1290926, Antimicrobial agents and chemotherapy, 2012, Romero-Sánchez, M Concepción et. al.
Dissemination of the fosfomycin resistance gene fosA3 with CTX-M β-lactamase genes and rmtB carried on IncFII plasmids among Escherichia coli isolates from pets in China.
score: 1.1290869, Antimicrobial agents and chemotherapy, 2012, Hou, Jianxia et. al.
Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes.
score: 1.1290262, Antimicrobial agents and chemotherapy, 2005, Wu, Jim Zhen et. al.
The oxime bond formation as an efficient chemical tool for the preparation of 3′,5′-bifunctionalised oligodeoxyribonucleotides
score: 1.1289893, Bioorganic & Medicinal Chemistry Letters, 2004, Edupuganti, Om Prakash et. al.
The bioisosteric similarity of the tetrazole and carboxylate anions: Clues from the topologies of the electrostatic potential and of the electron density
score: 1.1288557, European Journal of Medicinal Chemistry, 2010, Matta, Chérif F.; Arabi, Alya A.; Weaver, Donald F.
Chemo-enzymatic transformations in sensitive systems: Lipase mediated hydrolysis of vancomycin esters
score: 1.128851, Bioorganic & Medicinal Chemistry Letters, 1998, Adamczyk, Maciej; Grote, Jonathan; Rege, Sushil
Structure basis for the inhibitory mechanism of a novel DNase γ-specific inhibitor, DR396
score: 1.128846, Bioorganic & Medicinal Chemistry, 2006, Sunaga, Satoshi et. al.
7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid: a novel blue fluorescent dye for protein labeling
score: 1.128823, Bioorganic & Medicinal Chemistry Letters, 1999, Leung, Wai-Yee et. al.
In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria.
score: 1.1288036, Antimicrobial agents and chemotherapy, 2005, Yoon, Eun Jeong et. al.
Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates
score: 1.1287305, European Journal of Medicinal Chemistry, 2005, Kumar, Rohtash; Lown, J. William
ICESp1116, the Genetic Element Responsible for erm(B)-Mediated, Inducible Resistance to Erythromycin in Streptococcus pyogenes.
score: 1.1286222, Antimicrobial agents and chemotherapy, 2012, Brenciani, Andrea et. al.
Synthesis, spectral characterization and bio-analysis of some organotin(IV) complexes
score: 1.1286093, European Journal of Medicinal Chemistry, 2008, Rehman, Wajid; Baloch, Musa Kaleem; Badshah, Amin
Novel DNA/Polymer conjugate for intelligent antisense reagent with improved nuclease resistance
score: 1.1285744, Bioorganic & Medicinal Chemistry Letters, 2003, Murata, Masaharu et. al.
In vitro antibacterial properties of pexiganan, an analog of magainin.
score: 1.1285619, Antimicrobial agents and chemotherapy, 1999, Ge, Y et. al.
A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells
score: 1.1285544, Bioorganic & Medicinal Chemistry, 2012, Onen-Bayram, F. Esra et. al.
Substituted E-3-(2-Chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity
score: 1.1284484, Bioorganic & Medicinal Chemistry, 2004, Andreani, Aldo et. al.
Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children.
score: 1.1283951, Antimicrobial agents and chemotherapy, 2011, McNeil, J Chase et. al.
Propagation of TEM- and PSE-type beta-lactamases among amoxicillin-resistant Salmonella spp. isolated in France.
score: 1.1283933, Antimicrobial agents and chemotherapy, 1999, Llanes, C; Kirchgesner, V; Plesiat, P
In vivo selection of a chromosomally encoded beta-lactamase variant conferring ceftazidime resistance in Klebsiella oxytoca.
score: 1.1283729, Antimicrobial agents and chemotherapy, 2003, Mammeri, Hedi; Poirel, Laurent; Nordmann, Patrice
Synthesis and biological activities of indolocarbazoles bearing amino acid residues
score: 1.1283072, European Journal of Medicinal Chemistry, 2001, Moreau, Pascale et. al.
Predictive value of pharmacokinetics-adjusted phenotypic susceptibility on response to ritonavir-enhanced protease inhibitors (PIs) in human immunodeficiency virus-infected subjects failing prior PI therapy.
score: 1.1282472, Antimicrobial agents and chemotherapy, 2009, Eron, Joseph J et. al.
Synthesis and evaluation of glycosidase inhibitory activity of octahydro-2 H-pyrido[1,2- a]pyrimidine and octahydro-imidazo[1,2- a]pyridine bicyclic diazasugars
score: 1.128243, Bioorganic & Medicinal Chemistry, 2004, Dhavale, Dilip D et. al.
Bioconversion of silybin to phase I and II microbial metabolites with retained antioxidant activity
score: 1.1282163, Bioorganic & Medicinal Chemistry, 2012, Abourashed, Ehab A.; Mikell, Julie R.; Khan, Ikhlas A.
Bioconversion of silybin to phase I and II microbial metabolites with retained antioxidant activity
score: 1.1282163, Bioorganic & Medicinal Chemistry, 2012, Abourashed, Ehab A.; Mikell, Julie R.; Khan, Ikhlas A.
Bactericidal activity and postantibiotic effect of levofloxacin against anaerobes.
score: 1.1282129, Antimicrobial agents and chemotherapy, 1999, Pendland, S L et. al.
Relationships between respiration and susceptibility to azole antifungals in Candida glabrata.
score: 1.128177, Antimicrobial agents and chemotherapy, 2003, Brun, Sophie et. al.
Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones.
score: 1.1281287, Antimicrobial agents and chemotherapy, 2010, Pasca, Maria Rosalia et. al.
3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents
score: 1.1281203, Bioorganic & Medicinal Chemistry, 2012, Kelley, Cody et. al.
Cluster analysis of the DrugBank chemical space using molecular quantum numbers
score: 1.128109, Bioorganic & Medicinal Chemistry, 2012, Awale, Mahendra; Reymond, Jean-Louis
Asymmetric synthesis of β,γ-unsaturated α-amino acids via efficient kinetic resolution with cinchona alkaloids
score: 1.1279808, Bioorganic & Medicinal Chemistry Letters, 2009, Hang, Jianfeng; Deng, Li
Correlation between mutations in liaFSR of Enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints.
score: 1.1278651, Antimicrobial agents and chemotherapy, 2012, Munita, Jose M et. al.
Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture
score: 1.1277859, Bioorganic & Medicinal Chemistry Letters, 2012, Hirayama, Tasuku et. al.
Isolation of Klebsiella pneumoniae Producing NDM-1 Metallo-β-Lactamase from the Urine of an Outpatient Baby Boy Receiving Antibiotic Prophylaxis.
score: 1.1277632, Antimicrobial agents and chemotherapy, 2012, Mirovic, Veljko et. al.
Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe
score: 1.1277212, Bioorganic & Medicinal Chemistry Letters, 2012, Suganami, Akiko et. al.
Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe
score: 1.1277212, Bioorganic & Medicinal Chemistry Letters, 2012, Suganami, Akiko et. al.
Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe
score: 1.1277212, Bioorganic & Medicinal Chemistry Letters, 2012, Suganami, Akiko et. al.
Sulfamoyloxy-substituted 2-phenylindoles
score: 1.1275769, Bioorganic & Medicinal Chemistry, 2002, Golob, Thomas; Liebl, Renate; von Angerer, Erwin
International clone of Neisseria meningitidis serogroup A with tetracycline resistance due to tet(B).
score: 1.1274961, Antimicrobial agents and chemotherapy, 2005, Crawford, Sharon A et. al.
Plasmid location and molecular heterogeneity of the L1 and L2 beta-lactamase genes of Stenotrophomonas maltophilia.
score: 1.1274586, Antimicrobial agents and chemotherapy, 2001, Avison, M B et. al.
Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.
score: 1.1274224, Antimicrobial agents and chemotherapy, 2003, Riccio, Maria Letizia et. al.
Synthesis and evaluation of A-Ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D 3 (OCT) 1
score: 1.1273115, Bioorganic & Medicinal Chemistry, 2001, Hatakeyama, Susumi et. al.
Synthesis of an artificial hole-transporting nucleoside triphosphate, d MDATP, and its enzymatic incorporation into DNA
score: 1.1272572, Bioorganic & Medicinal Chemistry, 2004, Okamoto, Akimitsu et. al.
Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ.
score: 1.1272543, Antimicrobial agents and chemotherapy, 2001, Chuanchuen, R et. al.
Chromosome-encoded ambler class D beta-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase.
score: 1.1272454, Antimicrobial agents and chemotherapy, 2004, Poirel, Laurent; Héritier, Claire; Nordmann, Patrice
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
score: 1.1272429, Bioorganic & Medicinal Chemistry, 2012, Yamano, Yumiko et. al.
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
score: 1.1272429, Bioorganic & Medicinal Chemistry, 2012, Yamano, Yumiko et. al.
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
score: 1.1272429, Bioorganic & Medicinal Chemistry, 2012, Yamano, Yumiko et. al.
Potent DNA photocleavage by zinc(II) complexes of cationic bis-porphyrins linked with aliphatic diamine
score: 1.1272133, Bioorganic & Medicinal Chemistry, 2002, Ishikawa, Yoshinobu; Yamakawa, Naoki; Uno, Tadayuki
Synthesis and study of the cancer cell growth inhibitory properties of α-, γ-tocopheryl and γ-tocotrienyl 2-phenylselenyl succinates
score: 1.1271548, Bioorganic & Medicinal Chemistry, 2006, Vraka, Panayiota S. et. al.
Synthesis and properties of fluorescence probe for detection of peroxides in mitochondria
score: 1.1271305, Bioorganic & Medicinal Chemistry Letters, 2010, Shioji, Kosei; Oyama, Yu; Okuma, Kentaro; Nakagawa, Hiroyuki
A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P 3 and its effect on Cl −-secretion from T 84 cells
score: 1.1271251, Bioorganic & Medicinal Chemistry Letters, 1998, Rudolf, Marco T; Traynor-Kaplan, Alexis E; Schultz, Carsten
Multiparameter flow cytometric analysis of antibiotic effects on membrane potential, membrane permeability, and bacterial counts of Staphylococcus aureus and Micrococcus luteus.
score: 1.1271057, Antimicrobial agents and chemotherapy, 2000, Novo, D J; Perlmutter, N G; Hunt, R H; Shapiro, H M
Population pharmacokinetics of fluconazole in young infants.
score: 1.1270735, Antimicrobial agents and chemotherapy, 2008, Wade, K C et. al.
Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells.
score: 1.1270314, Antimicrobial agents and chemotherapy, 2004, Sudano Roccaro, Andrea et. al.
Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300
score: 1.1269852, Bioorganic & Medicinal Chemistry, 2003, Cebrat, Marek et. al.
Antimicrobial active macrocyclic complexes of Cr(III), Mn(III) and Fe(III) with their spectroscopic approach
score: 1.1269426, European Journal of Medicinal Chemistry, 2009, Singh, D.P.; Kumar, Krishan; Sharma, Chetan
In vitro interaction of terbinafine with itraconazole against clinical isolates of Scedosporium prolificans.
score: 1.1269188, Antimicrobial agents and chemotherapy, 2000, Meletiadis, J et. al.
Alterations in MurM, a cell wall muropeptide branching enzyme, increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae.
score: 1.1269051, Antimicrobial agents and chemotherapy, 2001, Smith, A M; Klugman, K P
Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD + and PGE 2 by homology modeling, docking and molecular dynamics simulation
score: 1.1269023, Bioorganic & Medicinal Chemistry, 2005, Hamza, Adel; Cho, Hoon; Tai, Hsin-Hsiung; Zhan, Chang-Guo
A facile and effective synthesis of dinucleotide 5′-triphosphates
score: 1.1268766, Bioorganic & Medicinal Chemistry, 2007, Abramova, Tatiana V. et. al.
Glycopeptide susceptibility profiles of Staphylococcus haemolyticus bloodstream isolates.
score: 1.1268754, Antimicrobial agents and chemotherapy, 2000, Biavasco, F; Vignaroli, C; Lazzarini, R; Varaldo, P E
Modulation of the rev-RRE interaction by aromatic heterocyclic compounds
score: 1.1268537, Bioorganic & Medicinal Chemistry, 1997, Zapp, Maria L. et. al.
A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes.
score: 1.1268018, Antimicrobial agents and chemotherapy, 1998, Seppälä, H; Skurnik, M; Soini, H; Roberts, M C; Huovinen, P
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity
score: 1.1268014, Bioorganic & Medicinal Chemistry, 1997, Pigini, Maria et. al.
Cytotoxic activities of alkylphosphocholines against clinical isolates of Acanthamoeba spp.
score: 1.1267274, Antimicrobial agents and chemotherapy, 2002, Walochnik, Julia et. al.
Comparing gatifloxacin and clarithromycin in pneumonia symptom resolution and process of care.
score: 1.1267264, Antimicrobial agents and chemotherapy, 2006, Dean, Nathan C et. al.
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: MurA confers clinical resistance at low fitness cost.
score: 1.1267108, Antimicrobial agents and chemotherapy, 2012, Couce, Alejandro et. al.
Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice.
score: 1.1266814, Antimicrobial agents and chemotherapy, 2010, Smee, Donald F et. al.
Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542.
score: 1.1266024, Antimicrobial agents and chemotherapy, 2004, Jacobson, Jeffrey M et. al.
Structural analysis of the immature form of the GFP homologue DsRed
score: 1.1265236, Bioorganic & Medicinal Chemistry Letters, 2003, Zaveer, M.Shahzad; Zimmer, Marc
Emergence of metallo-β-lactamase GIM-1 in a clinical isolate of Serratia marcescens.
score: 1.1264673, Antimicrobial agents and chemotherapy, 2012, Rieber, Heime; Frontzek, Andre; Pfeifer, Yvonne
Combination chemotherapy with the nitroimidazopyran PA-824 and first-line drugs in a murine model of tuberculosis.
score: 1.1264558, Antimicrobial agents and chemotherapy, 2006, Nuermberger, Eric et. al.
Design and synthesis of a cephalosporin-retinoic acid prodrug activated by a monoclonal antibody–β-lactamase conjugate
score: 1.1263473, Bioorganic & Medicinal Chemistry, 2001, Hakimelahi, Gholam H. et. al.
Combining molecular modeling with experimental methodologies: mechanism of membrane permeation and accumulation of ofloxacin
score: 1.1263341, Bioorganic & Medicinal Chemistry, 2002, Fresta, Massimo et. al.
Mutant prevention concentration-based pharmacokinetic/pharmacodynamic indices as dosing targets for suppressing the enrichment of levofloxacin-resistant subpopulations of Staphylococcus aureus.
score: 1.126332, Antimicrobial agents and chemotherapy, 2011, Liang, Beibei et. al.
Synthesis and structure/NMDA receptor affinity relationships of 1-substituted tetrahydro-3-benzazepines
score: 1.1263308, Bioorganic & Medicinal Chemistry, 2004, Krull, Olaf; Wünsch, Bernhard
Preparation and characterization of technetium and rhenium tricarbonyl complexes bearing the 4-nitrobenzyl moiety as potential bioreductive diagnostic radiopharmaceuticals. In vitro and in vivo studies
score: 1.1263039, European Journal of Medicinal Chemistry, 2008, Giglio, Javier et. al.
Aryl nucleoside H-phosphonates. Part 15: Synthesis, properties and, anti-HIV activity of aryl nucleoside 5′-α-hydroxyphosphonates
score: 1.1262353, Bioorganic & Medicinal Chemistry, 2006, Szymańska, Agnieszka et. al.
Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40.
score: 1.1262331, Antimicrobial agents and chemotherapy, 2006, Lolans, Karen et. al.
Heat-initiated detection for reduced glutathione with 19F NMR probes based on modified gold nanoparticles
score: 1.1262253, Bioorganic & Medicinal Chemistry Letters, 2013, Kitamura, Narufumi; Tanaka, Kazuo; Chujo, Yoshiki
Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes
score: 1.1260077, European Journal of Medicinal Chemistry, 2012, Xu, Qinyuan et. al.
Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium
score: 1.1259862, Bioorganic & Medicinal Chemistry Letters, 2005, Risitano, Antonina; Fox, Keith R.
Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding.
score: 1.1259245, Antimicrobial agents and chemotherapy, 2002, Lalezari, Jacob P et. al.
Investigations into self-association of vancomycin covalent dimers using surface plasmon resonance technology
score: 1.1258972, Bioorganic & Medicinal Chemistry Letters, 1999, Adamczyk, Maciej et. al.
Novispirin G10-induced lung toxicity in a Klebsiella pneumoniae infection model.
score: 1.1258926, Antimicrobial agents and chemotherapy, 2003, Bartlett, Karen H; McCray, Paul B; Thorne, Peter S
Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice.
score: 1.1258841, Antimicrobial agents and chemotherapy, 2011, Perez, Federico et. al.
Noninvasive pulmonary [18F]-2-fluoro-deoxy-D-glucose positron emission tomography correlates with bactericidal activity of tuberculosis drug treatment.
score: 1.1258239, Antimicrobial agents and chemotherapy, 2009, Davis, Stephanie L et. al.
Limonene arrests parasite development and inhibits isoprenylation of proteins in Plasmodium falciparum.
score: 1.1257577, Antimicrobial agents and chemotherapy, 2001, Moura, I C et. al.
Conformationally constrained butyrophenones as new pharmacological tools to study 5-HT 2A and 5-HT 2C receptor behaviours
score: 1.1257083, European Journal of Medicinal Chemistry, 2003, Brea, José et. al.
Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru.
score: 1.1256942, Antimicrobial agents and chemotherapy, 2008, Zhou, Zhiyong et. al.
First carbapenem-resistant isolates of Acinetobacter soli in Japan.
score: 1.1256487, Antimicrobial agents and chemotherapy, 2012, Endo, Shiro et. al.
On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I–DNA covalent binary complex
score: 1.1255873, Bioorganic & Medicinal Chemistry, 2005, Rahier, Nicolas J. et. al.
Impact of mutations outside the V3 region on coreceptor tropism phenotypically assessed in patients infected with HIV-1 subtype B.
score: 1.1255121, Antimicrobial agents and chemotherapy, 2011, Monno, Laura et. al.
Discovering transthyretin amyloid fibril inhibitors by limited screening
score: 1.1255095, Bioorganic & Medicinal Chemistry, 1998, Baures, Paul W.; Peterson, Scott A.; Kelly, Jeffery W.
Pseudomonas aeruginosa LasA protease in treatment of experimental staphylococcal keratitis.
score: 1.1254817, Antimicrobial agents and chemotherapy, 2004, Barequet, Irina S et. al.
Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties
score: 1.1254452, European Journal of Medicinal Chemistry, 2001, Sharma, Vibha; Khan, M.S.Y
A new Antennapedia-derived vector for intracellular delivery of exogenous compounds
score: 1.1254397, Bioorganic & Medicinal Chemistry Letters, 2001, Garcı́a-Echeverrı́a, C et. al.
Cysteine protease inhibitors as chemotherapy for parasitic infections
score: 1.1253891, Bioorganic & Medicinal Chemistry, 1999, McKerrow, James H; Engel, Juan C; Caffrey, Conor R
Synthesis and cytotoxicity of 1-substituted 2-methyl-1 H-imidazo[4,5- g]phthalazine-4,9-dione derivatives
score: 1.1251977, Bioorganic & Medicinal Chemistry, 2004, Sung Kim, Jin et. al.
In vivo antibacterial activity of S-3578, a new broad-spectrum cephalosporin: methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa experimental infection models.
score: 1.1250869, Antimicrobial agents and chemotherapy, 2003, Tsuji, Masakatsu et. al.
Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture.
score: 1.1250853, Antimicrobial agents and chemotherapy, 2006, Kahn, Jennifer Nielsen et. al.
Heterogeneity of macrolide-lincosamide-streptogramin B resistance phenotypes in enterococci.
score: 1.1250468, Antimicrobial agents and chemotherapy, 2003, Min, Yu-Hong et. al.
Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines
score: 1.125033, Bioorganic & Medicinal Chemistry, 2012, Lamberth, Clemens et. al.
Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines
score: 1.125033, Bioorganic & Medicinal Chemistry, 2012, Lamberth, Clemens et. al.
DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis.
score: 1.1250207, Antimicrobial agents and chemotherapy, 2011, Pantel, Alix et. al.
Direct PCR amplification of various modified DNAs having amino acids: Convenient preparation of DNA libraries with high-potential activities for in vitro selection
score: 1.1249654, Bioorganic & Medicinal Chemistry, 2006, Kuwahara, Masayasu et. al.
Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.
score: 1.1249645, Antimicrobial agents and chemotherapy, 2003, Dean, Charles R et. al.
Synthesis and in vitro evaluation of 68Ga-DOTA-4-FBn-TN14003, a novel tracer for the imaging of CXCR4 expression
score: 1.1248062, Bioorganic & Medicinal Chemistry, 2012, Hennrich, Ute et. al.
CANVAS 1 and 2: analysis of clinical response at day 3 in two phase 3 trials of ceftaroline fosamil versus vancomycin plus aztreonam in treatment of acute bacterial skin and skin structure infections.
score: 1.1247915, Antimicrobial agents and chemotherapy, 2012, Friedland, H David et. al.
Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study.
score: 1.124781, Antimicrobial agents and chemotherapy, 2006, Stryjewski, Martin E et. al.
Combination antimicrobial susceptibility testing of multidrug-resistant Stenotrophomonas maltophilia from cystic fibrosis patients.
score: 1.124755, Antimicrobial agents and chemotherapy, 2012, Milne, K E N; Gould, I M
Activities of bismuth thiols against staphylococci and staphylococcal biofilms.
score: 1.1246838, Antimicrobial agents and chemotherapy, 2001, Domenico, P et. al.
Therapeutic effects of water-soluble echinocandin compounds on Pneumocystis pneumonia in mice.
score: 1.1246557, Antimicrobial agents and chemotherapy, 1998, Furuta, T et. al.
Structural features of phenoxycarbonylimino neonicotinoids acting at the insect nicotinic receptor
score: 1.1245801, Bioorganic & Medicinal Chemistry Letters, 2010, Ohno, Ikuya et. al.
Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach
score: 1.1245501, European Journal of Medicinal Chemistry, 2005, Chande, Madhukar S. et. al.
Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline.
score: 1.1245257, Antimicrobial agents and chemotherapy, 2005, Fluit, Ad C; Florijn, Alice; Verhoef, Jan; Milatovic, Dana
Simulated Antibiotic Exposures in an In Vitro Hollow-Fiber Infection Model Influence Toxin Gene Expression and Production in Community-Associated Methicillin-Resistant Staphylococcus aureus Strain MW2.
score: 1.1244661, Antimicrobial agents and chemotherapy, 2012, Pichereau, Solen et. al.
Phenotypic and molecular analysis of penicillin-nonsusceptible Streptococcus pneumoniae isolates in Poland.
score: 1.1244522, Antimicrobial agents and chemotherapy, 2007, Sadowy, Ewa et. al.
Serendipitous discovery of an unexpected rearrangement leads to two new classes of potential protease inhibitors
score: 1.1244249, Bioorganic & Medicinal Chemistry, 2004, Zhong, Jiaying et. al.
Aptamers that bind to the antibiotic moenomycin A
score: 1.1244201, Bioorganic & Medicinal Chemistry, 2001, Schürer, Heike et. al.
Cytokine receptor dimerization and activation: prospects for small molecule agonists
score: 1.1243164, Bioorganic & Medicinal Chemistry, 2001, Boger, Dale L.; Goldberg, Joel
Two-step enzymatic synthesis of UDP- N-acetylgalactosamine
score: 1.1243046, Bioorganic & Medicinal Chemistry Letters, 2005, Bourgeaux, Vanessa; Piller, Friedrich; Piller, Véronique
Effects of triclosan-containing rinse on the dynamics and antimicrobial susceptibility of in vitro plaque ecosystems.
score: 1.1242365, Antimicrobial agents and chemotherapy, 2003, McBain, Andrew J et. al.
Synthesis and preliminary pharmacological results on new naphthalene derivatives as 5-HT 4 receptor ligands
score: 1.1242253, European Journal of Medicinal Chemistry, 2000, Diouf, Ousmane et. al.
Use of ribotyping to retrospectively identify methicillin-resistant Staphylococcus aureus isolates from phase 3 clinical trials for tigecycline that are genotypically related to community-associated isolates.
score: 1.1242027, Antimicrobial agents and chemotherapy, 2005, McAleese, Fionnuala et. al.
Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures.
score: 1.1240336, Antimicrobial agents and chemotherapy, 2010, Jiang, Zhi-Gang et. al.
Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of pulmonary aspergillosis.
score: 1.124007, Antimicrobial agents and chemotherapy, 2000, Matsumoto, S et. al.
Topological models for prediction of anti-HIV activity of acylthiocarbamates
score: 1.1239105, Bioorganic & Medicinal Chemistry, 2005, Bajaj, Sanjay; Sambi, S.S.; Madan, A.K.
A new candidate for insulinomimetic vanadium complex: synergism of oxovanadium(IV)porphyrin and sodium ascorbate
score: 1.1238722, Bioorganic & Medicinal Chemistry Letters, 2004, Sakurai, Hiromu et. al.
Chemical probes for profiling fatty acid-associated proteins in living cells
score: 1.1237811, Bioorganic & Medicinal Chemistry Letters, 2008, Raghavan, Anuradha et. al.
Tetracycline-resistant clinical Helicobacter pylori isolates with and without mutations in 16S rRNA-encoding genes.
score: 1.1237545, Antimicrobial agents and chemotherapy, 2005, Wu, Jeng Yih et. al.
In vitro susceptibilities of Rhodococcus equi and other common equine pathogens to azithromycin, clarithromycin, and 20 other antimicrobials.
score: 1.123679, Antimicrobial agents and chemotherapy, 2003, Jacks, Stephanie S; Giguère, Steeve; Nguyen, An
Interaction between posaconazole and caspofungin in concomitant treatment of mice with systemic Aspergillus infection.
score: 1.1236512, Antimicrobial agents and chemotherapy, 2006, Cacciapuoti, Anthony et. al.
Synthesis of new 2-galactosylthiazolidine-4-carboxylic acid amides. Antitumor evaluation against melanoma and breast cancer cells
score: 1.1236292, European Journal of Medicinal Chemistry, 2012, Serra, Arménio C. et. al.
Synthesis of new 2-galactosylthiazolidine-4-carboxylic acid amides. Antitumor evaluation against melanoma and breast cancer cells
score: 1.1236292, European Journal of Medicinal Chemistry, 2012, Serra, Arménio C. et. al.
Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody–multidrug immunoconjugates
score: 1.123582, Bioorganic & Medicinal Chemistry Letters, 2002, Sun, Chengzao; Wirsching, Peter; Janda, Kim D.
A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis.
score: 1.1235085, Antimicrobial agents and chemotherapy, 2004, Ghelardi, Emilia et. al.
Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against candida species
score: 1.1234613, Bioorganic & Medicinal Chemistry, 2002, Göker, Hakan et. al.
Tracking origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in Thailand.
score: 1.1233893, Antimicrobial agents and chemotherapy, 2011, Alam, Md Tauqeer et. al.
In vitro activities of linezolid against multiple Nocardia species.
score: 1.1233166, Antimicrobial agents and chemotherapy, 2001, Brown-Elliott, B A et. al.
8-(Pyren-1-yl)-2′-deoxyguanosine as an optical probe for DNA hybridization and for charge transfer with small peptides
score: 1.1233099, Bioorganic & Medicinal Chemistry Letters, 2006, Valis, Linda; Mayer-Enthart, Elke; Wagenknecht, Hans-Achim
Activation and desensitization of heteromeric neuronal nicotinic receptors: implications for non-synaptic transmission
score: 1.1232863, Bioorganic & Medicinal Chemistry Letters, 2004, Lester, Robin A.J
α-Hydroxyketones as inhibitors of urease
score: 1.1232764, Bioorganic & Medicinal Chemistry, 2004, Tanaka, Toru; Kawase, Masami; Tani, Satoru
Pharmacodynamics of telithromycin In vitro against respiratory tract pathogens.
score: 1.1232666, Antimicrobial agents and chemotherapy, 2001, Odenholt, I; Löwdin, E; Cars, O
Resin-supported labeling reagents
score: 1.123229, Bioorganic & Medicinal Chemistry Letters, 1999, Adamczyk, Maciej; Fishpaugh, Jeffrey R; Mattingly, Phillip G
Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement
score: 1.1232114, Bioorganic & Medicinal Chemistry Letters, 2003, Rastelli, Giulio; Pacchioni, Sara; Parenti, Marco Daniele
Effects of enrofloxacin on porcine phagocytic function.
score: 1.1231508, Antimicrobial agents and chemotherapy, 1999, Schoevers, E J et. al.
Reductions in skin and systemic parasite burdens as a combined effect of topical paromomycin and oral miltefosine treatment of mice experimentally infected with Leishmania (Leishmania) amazonensis.
score: 1.1231204, Antimicrobial agents and chemotherapy, 2010, Aguiar, Marta Gontijo et. al.
Influence of bulky 3,3′-diphenylalanine enantiomers replacing position 2 of AVP analogues on their conformations: NMR and molecular modeling studies
score: 1.1231189, European Journal of Medicinal Chemistry, 2010, Sikorska, Emilia et. al.
Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis.
score: 1.1230937, Antimicrobial agents and chemotherapy, 2000, Kirkpatrick, W R et. al.
Biosynthetic enzymes regulating ratios of sex pheromone components in female redbanded leafroller moths
score: 1.1230461, Bioorganic & Medicinal Chemistry, 1996, Roelofs, Wendell L.; Jurenka, Russell A.
Distribution of the cfiA gene among Bacteroides fragilis strains in Japan and relatedness of cfiA to imipenem resistance.
score: 1.1227662, Antimicrobial agents and chemotherapy, 1999, Yamazoe, K et. al.
Chemical Ligation to Obtain Proteins Comprising Helices with Individual Amino Acid Sequences
score: 1.1227339, Bioorganic & Medicinal Chemistry, 1999, Futaki, Shiroh et. al.
Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals.
score: 1.1226931, Antimicrobial agents and chemotherapy, 1999, Willems, R J et. al.
γ-Carbolines: binding at 5-HT 5A serotonin receptors
score: 1.1226627, Bioorganic & Medicinal Chemistry, 2003, Khorana, Nantaka et. al.
Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x.
score: 1.1226373, Antimicrobial agents and chemotherapy, 2006, Davies, Todd A; Shang, Wenchi; Bush, Karen
Recurrent episodes of candidemia due to Candida glabrata with a mutation in hot spot 1 of the FKS2 gene developed after prolonged therapy with caspofungin.
score: 1.1225951, Antimicrobial agents and chemotherapy, 2012, Durán-Valle, María Teresa et. al.
Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir.
score: 1.1225856, Antimicrobial agents and chemotherapy, 1999, Morfin, F et. al.
Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences
score: 1.1225639, Bioorganic & Medicinal Chemistry Letters, 2003, Reddy, Putta Mallikarjuna; Bruice, Thomas C.
Activity of LY333328 in experimental meningitis caused by a Streptococcus pneumoniae strain susceptible to penicillin.
score: 1.1225597, Antimicrobial agents and chemotherapy, 2001, Gerber, J et. al.
Synthesis and cellular studies of an octa-anionic 5,10,15,20-tetra[3,5-( nido-carboranylmethyl)phenyl]porphyrin (H 2OCP) for application in BNCT
score: 1.1225567, Bioorganic & Medicinal Chemistry, 2005, Gottumukkala, Vijay et. al.
Molecular characterization of chromosomal class C beta-lactamase and its regulatory gene in Ochrobactrum anthropi.
score: 1.1225547, Antimicrobial agents and chemotherapy, 2001, Nadjar, D et. al.
Susceptibility of recently collected Spanish pneumococci nonsusceptible to oral penicillin from serotypes not included in the 7-valent conjugate vaccine.
score: 1.1225473, Antimicrobial agents and chemotherapy, 2010, Fenoll, Asunción et. al.
Microwave assisted solid support synthesis of novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazepines as potent antimicrobial agents
score: 1.12251, Bioorganic & Medicinal Chemistry, 2001, Kidwai, M; Sapra, P; Misra, P; Saxena, R.K; Singh, M
Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action.
score: 1.1224239, Antimicrobial agents and chemotherapy, 2000, Adrian, P V et. al.
Molecular Modeling of Protein Tyrosine Phosphatase 1B (PTP 1B) Inhibitors
score: 1.1224064, Bioorganic & Medicinal Chemistry, 2002, Murthy, V.Sreenivasa; Kulkarni, Vithal M
Pharmacokinetics of the protease inhibitor KNI-272 in plasma and cerebrospinal fluid in nonhuman primates after intravenous dosing and in human immunodeficiency virus-infected children after intravenous and oral dosing.
score: 1.1223953, Antimicrobial agents and chemotherapy, 1998, Mueller, B U et. al.
Antennal response and field attraction of the predator Elatophilus hebraicus (Hemiptera: Anthocoridae) to sex pheromones and analogues of three Matsucoccus spp. (Homoptera: Matsucoccidae)
score: 1.1223033, Bioorganic & Medicinal Chemistry, 1996, Dunkelblum, Ezra et. al.
Effect of azithromycin plus rifampin versus that of azithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis.
score: 1.1221463, Antimicrobial agents and chemotherapy, 1999, Wolf, K; Malinverni, R
Bioisosterically modified dipeptide excitatory amino acid receptor antagonists containing 3-oxygenated isothiazole ring systems
score: 1.1221402, Bioorganic & Medicinal Chemistry, 1997, Matzen, Lisa et. al.
Bioisosterically modified dipeptide excitatory amino acid receptor antagonists containing 3-oxygenated isothiazole ring systems
score: 1.1221402, Bioorganic & Medicinal Chemistry, 1997, Matzen, Lisa et. al.
In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp.
score: 1.1220989, Antimicrobial agents and chemotherapy, 2002, Arikan, Sevtap et. al.
Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice.
score: 1.1219891, Antimicrobial agents and chemotherapy, 2000, Deepe, G S; Gibbons, R
Origin of OXA-181, an emerging carbapenem-hydrolyzing oxacillinase, as a chromosomal gene in Shewanella xiamenensis.
score: 1.1219791, Antimicrobial agents and chemotherapy, 2011, Potron, Anaïs; Poirel, Laurent; Nordmann, Patrice
Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics.
score: 1.1219623, Antimicrobial agents and chemotherapy, 2012, Khan, Saira et. al.
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
score: 1.1219544, Nature chemical biology, 2011, Di Paolo, Julie A et. al.
Antimicrobial susceptibilities and clinical sources of Facklamia species.
score: 1.1218839, Antimicrobial agents and chemotherapy, 2000, LaClaire, L; Facklam, R
Evaluation of antibiotic therapy for eradication of "Candidatus Helicobacter heilmannii".
score: 1.1218714, Antimicrobial agents and chemotherapy, 2008, Matsui, Hidenori et. al.
In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains.
score: 1.1218562, Antimicrobial agents and chemotherapy, 2006, Maisetta, Giuseppantonio et. al.
Antibiotic susceptibility in relation to penicillin-binding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002.
score: 1.1217531, Antimicrobial agents and chemotherapy, 2004, Ubukata, Kimiko et. al.
In vitro interactions of artemisinin with atovaquone, quinine, and mefloquine against Plasmodium falciparum.
score: 1.1217344, Antimicrobial agents and chemotherapy, 2002, Gupta, S; Thapar, M M; Wernsdorfer, W H; Björkman, A
Inhibition of HIV tat–TAR interactions by an antisense oligo-2′- O-methylribonucleoside methylphosphonate
score: 1.1217338, Bioorganic & Medicinal Chemistry Letters, 2003, Hamma, Tomoko et. al.
Development of a new experimental model of penicillin-resistant Streptococcus pneumoniae pneumonia and amoxicillin treatment by reproducing human pharmacokinetics.
score: 1.121649, Antimicrobial agents and chemotherapy, 1999, Piroth, L et. al.
Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives
score: 1.1216044, European Journal of Medicinal Chemistry, 2012, Gurkan-Alp, A. Selen et. al.
Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives
score: 1.1216044, European Journal of Medicinal Chemistry, 2012, Gurkan-Alp, A. Selen et. al.
In vitro bactericidal activities of ABT-773 against ermB strains of Streptococcus pneumoniae.
score: 1.1215917, Antimicrobial agents and chemotherapy, 2003, Neuhauser, Melinda M et. al.
Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974.
score: 1.1215619, Antimicrobial agents and chemotherapy, 2009, Zeng, Yu et. al.
Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries
score: 1.1215179, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Pik-Ling et. al.
Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries
score: 1.1215179, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Pik-Ling et. al.
Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries
score: 1.1215179, Bioorganic & Medicinal Chemistry Letters, 2012, Lam, Pik-Ling et. al.
FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy.
score: 1.121494, Antimicrobial agents and chemotherapy, 2011, Costa-de-Oliveira, Sofia et. al.
Development and validation of a high-performance liquid chromatography assay for voriconazole.
score: 1.1214661, Antimicrobial agents and chemotherapy, 2003, Pennick, Gennethel J et. al.
Controllable synthesis of polymerizable ester and amide prodrugs of acyclovir by enzyme in organic solvent
score: 1.121404, Bioorganic & Medicinal Chemistry, 2006, Li, Xia; Wu, Qi; Lv, De-shui; Lin, Xian-fu
Pharmacokinetic effects of coadministration of lersivirine with raltegravir or maraviroc in healthy subjects.
score: 1.1213749, Antimicrobial agents and chemotherapy, 2012, Vourvahis, Manoli et. al.
Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania.
score: 1.1213408, Antimicrobial agents and chemotherapy, 2003, Bakonyte, Daiva et. al.
Intrastrand base-stacking buttresses widening of major groove in interstrand cross-linked B-DNA
score: 1.1213265, Bioorganic & Medicinal Chemistry, 2005, da Silva, Mateus Webba et. al.
Efficacious topical treatment for murine cutaneous leishmaniasis with ethanolic formulations of amphotericin B.
score: 1.1212618, Antimicrobial agents and chemotherapy, 1998, Frankenburg, S; Glick, D; Klaus, S; Barenholz, Y
Structure–activity studies on 4-substituted-2-anilinopyrimidine corticotropin releasing factor (CRF) antagonists
score: 1.1212049, Bioorganic & Medicinal Chemistry, 1999, Gilligan, Paul J. et. al.
Isothermal sensitive detection of microRNA using an autonomous DNA machine recycling output as input
score: 1.1211846, Bioorganic & Medicinal Chemistry Letters, 2010, Ogawa, Atsushi
Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: pyridazines
score: 1.1211185, Bioorganic & Medicinal Chemistry, 2012, Lamberth, Clemens et. al.
Prevalence of mutations associated with higher levels of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Car Nicobar Island and Assam, India.
score: 1.1211179, Antimicrobial agents and chemotherapy, 2006, Ahmed, Anwar et. al.
HIV-1 protease mutations and protease inhibitor cross-resistance.
score: 1.1211038, Antimicrobial agents and chemotherapy, 2010, Rhee, Soo-Yon et. al.
Deregulation of the arginine deiminase (arc) operon in penicillin-tolerant mutants of Streptococcus gordonii.
score: 1.1210986, Antimicrobial agents and chemotherapy, 2000, Caldelari, I et. al.
Pyrrolo-quinoline derivatives as potential antineoplastic drugs
score: 1.121093, Bioorganic & Medicinal Chemistry, 2000, Ferlin, M.G; Gatto, B; Chiarelotto, G; Palumbo, M
The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II.
score: 1.1210827, Antimicrobial agents and chemotherapy, 1998, Brötz, H; Bierbaum, G; Leopold, K; Reynolds, P E; Sahl, H G
Antifungal diterpenoids of Pseudolarix kaempferi, and their structure–activity relationship study
score: 1.1210222, Bioorganic & Medicinal Chemistry, 2003, Yang, Sheng-Ping et. al.
Macrolide resistance genes in Enterococcus spp.
score: 1.1209505, Antimicrobial agents and chemotherapy, 2000, Portillo, A et. al.
Nomenclature of GES-type extended-spectrum beta-lactamases.
score: 1.1208985, Antimicrobial agents and chemotherapy, 2005, Lee, Sang Hee; Jeong, Seok Hoon
Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC)
score: 1.1208718, Bioorganic & Medicinal Chemistry, 2012, Krumm, Patrick et. al.
Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity.
score: 1.1208658, Antimicrobial agents and chemotherapy, 2005, Louie, Arnold et. al.
Pentamidine is active in vitro against Fusarium species.
score: 1.120828, Antimicrobial agents and chemotherapy, 2003, Lionakis, Michail S et. al.
Ritonavir-saquinavir dual protease inhibitor compared to ritonavir alone in human immunodeficiency virus-infected patients.
score: 1.1207107, Antimicrobial agents and chemotherapy, 2001, Michelet, C et. al.
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma
score: 1.1206154, Bioorganic & Medicinal Chemistry, 2012, Imai, Masahiko; Takahashi, Noriko
4′-Fluorinated carbocyclic nucleosides: Synthesis and inhibitory activity against S-adenosyl- l-homocysteine hydrolase
score: 1.1204905, Bioorganic & Medicinal Chemistry, 2006, Kitade, Yukio et. al.
In vitro activity of ertapenem versus ceftriaxone against Neisseria gonorrhoeae isolates with highly diverse ceftriaxone MIC values and effects of ceftriaxone resistance determinants: ertapenem for treatment of gonorrhea?
score: 1.1204665, Antimicrobial agents and chemotherapy, 2012, Unemo, Magnus et. al.
Synthesis and biological evaluation of 4’-[(benzimidazole-1- yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensinII/ endothelin A receptor antagonists
score: 1.1203665, Bioorganic & Medicinal Chemistry, 2012, Bai, Renren et. al.
Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors.
score: 1.1203659, Antimicrobial agents and chemotherapy, 2002, Birkus, Gabriel; Hitchcock, Michael J M; Cihlar, Tomas
In vitro susceptibilities of Shigella flexneri and Streptococcus pyogenes to inner gel of Aloe barbadensis Miller.
score: 1.1203442, Antimicrobial agents and chemotherapy, 2003, Ferro, Valerie A et. al.
Synthesis, characterization antibacterial and antiproliferative activity of novel Cu(II) and Pd(II) complexes with 2-hydroxy-8-R-tricyclo[7.3.1.0. 2,7]tridecane-13-one thiosemicarbazone
score: 1.1202893, European Journal of Medicinal Chemistry, 2010, Rosu, Tudor et. al.
Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.
score: 1.1201563, Antimicrobial agents and chemotherapy, 2005, Davis, Kepler A et. al.
Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives
score: 1.1201559, Bioorganic & Medicinal Chemistry, 2004, Shih, Mei-Hsiu; Ke, Fang-Ying
Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents
score: 1.1201399, European Journal of Medicinal Chemistry, 2012, Patel, Rahul V. et. al.
Optimizing Echinocandin Dosing and Susceptibility Breakpoint Determination via In Vivo Pharmacodynamic Evaluation against Candida glabrata with and without fks Mutations.
score: 1.1201264, Antimicrobial agents and chemotherapy, 2012, Lepak, Alexander et. al.
Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri.
score: 1.1201164, Antimicrobial agents and chemotherapy, 1998, Yang, Y et. al.
Characterization of SFO-1, a plasmid-mediated inducible class A beta-lactamase from Enterobacter cloacae.
score: 1.1200922, Antimicrobial agents and chemotherapy, 1999, Matsumoto, Y; Inoue, M
glmM operon and methicillin-resistant glmM suppressor mutants in Staphylococcus aureus.
score: 1.1200743, Antimicrobial agents and chemotherapy, 1999, Glanzmann, P et. al.
Evaluation of disk diffusion method for determining posaconazole susceptibility of filamentous fungi: comparison with CLSI broth microdilution method.
score: 1.1200173, Antimicrobial agents and chemotherapy, 2006, López-Oviedo, E et. al.
A new spacer group derived from arylmalonaldehydes for glucuronylated prodrugs
score: 1.1200026, Bioorganic & Medicinal Chemistry Letters, 1998, Papot, Sébastien; Combaud, Damien; Gesson, Jean-Pierre
Rapid Microarray-Based Identification of Different mecA Alleles in Staphylococci.
score: 1.119797, Antimicrobial agents and chemotherapy, 2012, Monecke, Stefan et. al.
Difference in incidence of spontaneous mutations between Herpes simplex virus types 1 and 2.
score: 1.1197909, Antimicrobial agents and chemotherapy, 2000, Sarisky, R T et. al.
Activities of synthetic hybrid peptides against anaerobic bacteria: aspects of methodology and stability.
score: 1.1197906, Antimicrobial agents and chemotherapy, 2000, Oh, H; Hedberg, M; Wade, D; Edlund, C
Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety
score: 1.1197478, Bioorganic & Medicinal Chemistry, 1996, Priestley, Nigel D. et. al.
Reactions of a series of 1-Aminobenzimidazoles and 1-Amino-3-methylbenzimidazolium chlorides with 2,4-pentanedione
score: 1.1197298, Bioorganic & Medicinal Chemistry, 2000, Kaiya, Toyo; Aoyama, Shinsuke; Kohda, Kohfuku
Direct measurement of the anti-influenza agent zanamivir in the respiratory tract following inhalation.
score: 1.1197269, Antimicrobial agents and chemotherapy, 2000, Peng, A W; Milleri, S; Stein, D S
Conjugates of 5-isoquinolinesulfonylamides and oligo-d-arginine possess high affinity and selectivity towards Rho kinase (ROCK)
score: 1.1197162, Bioorganic & Medicinal Chemistry Letters, 2012, Lavogina, Darja et. al.
Conjugates of 5-isoquinolinesulfonylamides and oligo-d-arginine possess high affinity and selectivity towards Rho kinase (ROCK)
score: 1.1197162, Bioorganic & Medicinal Chemistry Letters, 2012, Lavogina, Darja et. al.
Conjugates of 5-isoquinolinesulfonylamides and oligo-d-arginine possess high affinity and selectivity towards Rho kinase (ROCK)
score: 1.1197162, Bioorganic & Medicinal Chemistry Letters, 2012, Lavogina, Darja et. al.
Mechanism of sulfonamide resistance in clinical isolates of Streptococcus pneumoniae.
score: 1.1196815, Antimicrobial agents and chemotherapy, 1997, Maskell, J P; Sefton, A M; Hall, L M
Structural development of biological response modifiers based on thalidomide
score: 1.1196619, Bioorganic & Medicinal Chemistry, 2002, Hashimoto, Yuichi
New unusual iridoids from the leaves of noni ( Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity
score: 1.1194758, Bioorganic & Medicinal Chemistry, 2003, Sang, Shengmin et. al.
Photo-caged agonists of the nuclear receptors RARγ and TRβ provide unique time-dependent gene expression profiles for light-activated gene patterning
score: 1.119443, Bioorganic & Medicinal Chemistry, 2004, Link, Kristian H. et. al.
RNAi gene silencing using cerasome as a viral-size siRNA-carrier free from fusion and cross-linking
score: 1.1193466, Bioorganic & Medicinal Chemistry Letters, 2007, Matsui, Kazuki et. al.
Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals.
score: 1.1193241, Antimicrobial agents and chemotherapy, 2012, Pfeifer, Yvonne et. al.
In vitro selection of RNA aptamer against Escherichia coli release factor 1
score: 1.119246, Bioorganic & Medicinal Chemistry Letters, 2007, Sando, Shinsuke et. al.
Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis.
score: 1.119181, Antimicrobial agents and chemotherapy, 2006, Serrano-Martín, Xenón et. al.
New thiazane and thiazolidine PNA monomers: synthesis, incorporation into PNAs and hybridization studies
score: 1.1191764, Bioorganic & Medicinal Chemistry Letters, 2002, Bregant, Sarah; Burlina, Fabienne; Chassaing, Gérard
2,3-Disubstituted 6-azabicyclo[3.2.1]octanes as novel dopamine transporter inhibitors
score: 1.1191473, Bioorganic & Medicinal Chemistry, 2004, Quirante, Josefina et. al.
Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.
score: 1.119075, Antimicrobial agents and chemotherapy, 2001, Yan, J J et. al.
Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides.
score: 1.1190093, Antimicrobial agents and chemotherapy, 2004, Catalone, Bradley J et. al.
72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
score: 1.1189953, Bioorganic & Medicinal Chemistry Letters, 2010, Herth, Matthias M. et. al.
The triple combination indinavir-zidovudine-lamivudine is highly synergistic.
score: 1.118934, Antimicrobial agents and chemotherapy, 2000, Snyder, S et. al.
Fluorescence sensing of caffeine in aqueous solution with carbazole-based probe and imaging application in live cells
score: 1.1187936, Bioorganic & Medicinal Chemistry Letters, 2012, Mahapatra, Ajit Kumar et. al.
CFE-1, a novel plasmid-encoded AmpC beta-lactamase with an ampR gene originating from Citrobacter freundii.
score: 1.1187908, Antimicrobial agents and chemotherapy, 2004, Nakano, Ryuichi et. al.
Single-dose intraperitoneal magainins improve survival in a gram-negative-pathogen septic shock rat model.
score: 1.1187147, Antimicrobial agents and chemotherapy, 2002, Cirioni, Oscar et. al.
Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
score: 1.1186414, Antimicrobial agents and chemotherapy, 2005, Chambers, Henry F
Retraction notice to “Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrug of 5-aminosalicylic acid with d-phenylalanine for colon specific drug delivery in inflammatory bowel disease” [Bioorg. Med. Chem. Lett. 17 (2007) 1897–1902]
score: 1.1186259, Bioorganic & Medicinal Chemistry Letters, 2009, Dhaneshwar, Suneela S. et. al.
Pharmacokinetics, serum inhibitory and bactericidal activity, and safety of telavancin in healthy subjects.
score: 1.1186122, Antimicrobial agents and chemotherapy, 2005, Shaw, J P et. al.
Chloropyrimidines as a new class of antimicrobial agents
score: 1.1186035, Bioorganic & Medicinal Chemistry, 2002, Agarwal, Nidhi et. al.
Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin
score: 1.1185753, Bioorganic & Medicinal Chemistry, 2013, Juncosa, Jose I. et. al.
A simple, solid-phase binding assay for the nuclear import receptor karyopherin α. Part 2: competitive binding
score: 1.1185711, Bioorganic & Medicinal Chemistry Letters, 2000, Park, Seung Bum; Reedy, Brian M.; Standaert , Robert F.
Time-kill studies of the antianaerobe activity of garenoxacin compared with those of nine other agents.
score: 1.1184974, Antimicrobial agents and chemotherapy, 2003, Credito, Kim L; Jacobs, Michael R; Appelbaum, Peter C
Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats
score: 1.1183009, Bioorganic & Medicinal Chemistry Letters, 2008, Li, Xinming et. al.
Mechanisms Decreasing In Vitro Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa.
score: 1.1182689, Antimicrobial agents and chemotherapy, 2012, Caughlan, Ruth E et. al.
Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.
score: 1.1182542, Antimicrobial agents and chemotherapy, 2006, Peltroche-Llacsahuanga, Heidrun et. al.
Antipneumococcal activity of DK-507k, a new quinolone, compared with the activities of 10 other agents.
score: 1.1181706, Antimicrobial agents and chemotherapy, 2003, Browne, Frederick A et. al.
Challenges in designing animal studies to detect antagonism of polyene activity.
score: 1.1181638, Antimicrobial agents and chemotherapy, 2004, Lewis, Russell E et. al.
Increasing prevalence of quinolone resistance in human nontyphoid Salmonella enterica isolates obtained in Spain from 1981 to 2003.
score: 1.1181414, Antimicrobial agents and chemotherapy, 2004, Marimón, José M et. al.
High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein.
score: 1.1181075, Antimicrobial agents and chemotherapy, 2003, Gubbels, Marc-Jan; Li, Catherine; Striepen, Boris
Examination of methicillin-resistant and methicillin-susceptible Staphylococcus aureus mutants with low-level fluoroquinolone resistance.
score: 1.1180839, Antimicrobial agents and chemotherapy, 1998, Sulavik, M C; Barg, N L
DNA strand scission by a Cu(I)·adenylated polymeric template: preliminary mechanistic and recycling studies
score: 1.1180712, Bioorganic & Medicinal Chemistry Letters, 2003, Verma, Sandeep et. al.
Maraviroc and other HIV-1 entry inhibitors exhibit a class-specific redistribution effect that results in increased extracellular viral load.
score: 1.1180489, Antimicrobial agents and chemotherapy, 2012, Kramer, Victor G et. al.
( 3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells
score: 1.1180145, Bioorganic & Medicinal Chemistry, 2004, Niiro, Hayato et. al.
Alterations in GyrA and ParC associated with fluoroquinolone resistance in Enterococcus faecium.
score: 1.1179846, Antimicrobial agents and chemotherapy, 1999, el Amin, N A; Jalal, S; Wretlind, B
One new LEN enzyme and two new OKP enzymes in Klebsiella pneumoniae clinical isolates and proposed nomenclature for chromosomal beta-lactamases of this species.
score: 1.1179288, Antimicrobial agents and chemotherapy, 2005, Siebor, Eliane et. al.
Tumor cell-specific prodrugs using arsonic acid-presenting iron oxide nanoparticles with high sensitivity
score: 1.1178969, Bioorganic & Medicinal Chemistry, 2012, Minehara, Hiroki et. al.
Design and synthesis of a multivalent homing device for targeting to murine CD22
score: 1.1178925, Bioorganic & Medicinal Chemistry, 2001, Sliedregt, Leo A.J.M. et. al.
First synthesis of the 3′ - sulfated Lewis a pentasaccharide, the most potent human E-selectin ligand so far
score: 1.1178021, Bioorganic & Medicinal Chemistry, 1994, Lubineau, André; Le Gallic, Joëlle; Lemoine, Rémy
Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole–imidazole polyamides
score: 1.1177886, Bioorganic & Medicinal Chemistry Letters, 2005, Price, Carly A. et. al.
In vitro antibacterial activities of platelet microbicidal protein and neutrophil defensin against Staphylococcus aureus are influenced by antibiotics differing in mechanism of action.
score: 1.1177363, Antimicrobial agents and chemotherapy, 1999, Xiong, Y Q; Yeaman, M R; Bayer, A S
Unique hole-Trapping property of the degenerate base,2-amino-7-deazaadenine
score: 1.1176199, Bioorganic & Medicinal Chemistry Letters, 2002, Okamoto, Akimitsu; Tanaka, Kazuo; Saito, Isao
In vitro monitoring of nanogram levels of puerarin in human urine using flow injection chemiluminescence
score: 1.1175083, Bioorganic & Medicinal Chemistry Letters, 2004, Wang, Changna; Song, Zhenghua
Penetration of clindamycin and its metabolite N-demethylclindamycin into cerebrospinal fluid following intravenous infusion of clindamycin phosphate in patients with AIDS.
score: 1.1174414, Antimicrobial agents and chemotherapy, 1998, Gatti, G et. al.
Salen complexes with bulky substituents as useful tools for biomimetic phenol oxidation research
score: 1.1174328, Bioorganic & Medicinal Chemistry, 2001, Haikarainen, Anssi et. al.
Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing.
score: 1.1172445, Antimicrobial agents and chemotherapy, 2004, Rhee, Soo-Yon et. al.
Effectiveness of anidulafungin in eradicating Candida species in invasive candidiasis.
score: 1.1171664, Antimicrobial agents and chemotherapy, 2005, Pfaller, M A et. al.
Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia.
score: 1.1170854, Antimicrobial agents and chemotherapy, 2005, Lavender, Caroline et. al.
Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.
score: 1.1169559, Antimicrobial agents and chemotherapy, 2011, Papagiannitsis, C C et. al.
Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D 4-Ligands
score: 1.1168415, Bioorganic & Medicinal Chemistry, 2002, Moll, Annette et. al.
In vitro activity of trovafloxacin against Bacteroides fragilis in mixed culture with either Escherichia coli or a vancomycin- resistant strain of Enterococcus faecium determined by an anaerobic time-kill technique.
score: 1.1168282, Antimicrobial agents and chemotherapy, 2001, Stearne, L E et. al.
N-(3-acyloxy-2-benzylpropyl)- N′-(4-hydroxy-3-methoxybenzyl)thiourea derivatives as potent vanilloid receptor agonists and analgesics
score: 1.1167513, Bioorganic & Medicinal Chemistry, 2001, Lee, Jeewoo et. al.
Synthesis and characterization of αvβ3-targeting peptidomimetic chelate conjugates for PET and SPECT imaging
score: 1.116695, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Young-Seung et. al.
Synthesis and applications of a deep, asymmetric cavitand on a solid support
score: 1.1166942, Bioorganic & Medicinal Chemistry Letters, 2001, Saito, Shoichi; Rebek, Julius
Novel fluorescent labelled affinity probes for diadenosine-5′,5‴- P 1, P 4-tetraphosphate (Ap 4A)-binding studies
score: 1.1166846, Bioorganic & Medicinal Chemistry Letters, 2006, Wright, Michael; Miller, Andrew D.
Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis.
score: 1.11668, Antimicrobial agents and chemotherapy, 2009, Cheng, Allen C et. al.
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands
score: 1.1166785, Bioorganic & Medicinal Chemistry Letters, 2012, Banister, Samuel D.; Rendina, Louis M.; Kassiou, Michael
Improving the intein-mediated, site-specific protein biotinylation strategies both in vitro and in vivo
score: 1.116655, Bioorganic & Medicinal Chemistry Letters, 2004, Tan, Lay-Pheng et. al.
In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.
score: 1.1166451, Antimicrobial agents and chemotherapy, 2006, Jacqueline, Cedric et. al.
In vitro interactions of antimicrobial combinations with fosfomycin against KPC-2-producing Klebsiella pneumoniae and protection of resistance development.
score: 1.1166422, Antimicrobial agents and chemotherapy, 2011, Souli, Maria et. al.
Immunomodulating properties of the antibiotic novobiocin in human monocytes.
score: 1.1165609, Antimicrobial agents and chemotherapy, 1998, Lührmann, A et. al.
Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor 1 receptor antagonists
score: 1.1165525, Bioorganic & Medicinal Chemistry, 2001, Kumagai, Toshihito et. al.
Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice.
score: 1.1164891, Antimicrobial agents and chemotherapy, 2004, Stiefel, Usha et. al.
A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the bla(OXA-23) gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii.
score: 1.1164413, Antimicrobial agents and chemotherapy, 2011, Lee, Yangsoon et. al.
In vitro pharmacodynamics of the new ketolides HMR 3004 and HMR 3647 (Telithromycin) against Chlamydia pneumoniae.
score: 1.1164043, Antimicrobial agents and chemotherapy, 2000, Gustafsson, I; Hjelm, E; Cars, O
Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies
score: 1.1163091, Bioorganic & Medicinal Chemistry, 2002, Shi, Zhen-Dan et. al.
Crystallographic studies on N-azidoacetyl-β- d-glucopyranosylamine, an inhibitor of glycogen phosphorylase: Comparison with N-acetyl-β- d-glucopyranosylamine
score: 1.1162899, Bioorganic & Medicinal Chemistry, 2006, Petsalakis, Evangelia I. et. al.
Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity.
score: 1.1162623, Antimicrobial agents and chemotherapy, 2008, Simon, Anna et. al.
Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill.
score: 1.1161028, Antimicrobial agents and chemotherapy, 2012, Mohamed, Ami F et. al.
Stenotrophomonas maltophilia D457R contains a cluster of genes from gram-positive bacteria involved in antibiotic and heavy metal resistance.
score: 1.1160755, Antimicrobial agents and chemotherapy, 2000, Alonso, A; Sanchez, P; Martínez, J L
Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patients.
score: 1.1160697, Antimicrobial agents and chemotherapy, 2011, Lortholary, Olivier et. al.
Chemico-enzymatic synthesis of a new fluorescent-labeled DNA by PCR with a thymidine nucleotide analogue bearing an acridone derivative
score: 1.1160219, Bioorganic & Medicinal Chemistry Letters, 2007, Shoji, Atsushi et. al.
Clinafloxacin pharmacokinetics in subjects with various degrees of renal function.
score: 1.1159603, Antimicrobial agents and chemotherapy, 2001, Randinitis, E J et. al.
Synthesis and cytotoxicity of diam(m)ineplatinum(II) complexes with 2,2-bis(hydroxymethyl)malonate as the leaving group
score: 1.1159506, Bioorganic & Medicinal Chemistry Letters, 2012, Xing, Yingjuan et. al.
Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.
score: 1.1158758, Antimicrobial agents and chemotherapy, 2001, Lennerstrand, J; Stammers, D K; Larder, B A
The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
score: 1.1158358, Antimicrobial agents and chemotherapy, 2012, Holmes, Ann R et. al.
Genotypic and phenotypic resistance patterns of human immunodeficiency virus type 1 variants with insertions or deletions in the reverse transcriptase (RT): multicenter study of patients treated with RT inhibitors.
score: 1.1157927, Antimicrobial agents and chemotherapy, 2001, Masquelier, B et. al.
Antifungal therapy of experimental cerebral phaeohyphomycosis due to Cladophialophora bantiana.
score: 1.1157531, Antimicrobial agents and chemotherapy, 2005, Al-Abdely, Hail M et. al.
2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding.
score: 1.1155512, Molecular pharmacology, 2002, Hughes, Richard A et. al.
Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance.
score: 1.1155063, Antimicrobial agents and chemotherapy, 2012, Katiyar, Santosh K et. al.
Orally administered targeted recombinant Beta-lactamase prevents ampicillin-induced selective pressure on the gut microbiota: a novel approach to reducing antimicrobial resistance.
score: 1.1154462, Antimicrobial agents and chemotherapy, 2004, Harmoinen, Jaana et. al.
Femtosecond time-resolved guanine oxidation in acridine modified alanyl peptide nucleic acids
score: 1.1152924, Bioorganic & Medicinal Chemistry Letters, 2004, Weicherding, D. et. al.
Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface
score: 1.1152759, Bioorganic & Medicinal Chemistry, 2006, Furuya, Minoru; Haramura, Masayuki; Tanaka, Akito
Selective recognition of a C-G base-pair in the parallel DNA triple-helical binding motif
score: 1.1152671, Bioorganic & Medicinal Chemistry Letters, 1999, Prévot-Halter, Isabelle; Leumann, Christian J.
A new approach for investigating protein flexibility based on Constraint Logic Programming. The first application in the case of the estrogen receptor
score: 1.1152281, European Journal of Medicinal Chemistry, 2012, Dal Palú, Alessandro; Spyrakis, Francesca; Cozzini, Pietro
Efficacy and safety of a novel once-daily extended-release ciprofloxacin tablet formulation for treatment of uncomplicated urinary tract infection in women.
score: 1.1152156, Antimicrobial agents and chemotherapy, 2005, Fourcroy, Jean L et. al.
Identification and structural determination of a potent p-selectin inhibitor
score: 1.1152124, Bioorganic & Medicinal Chemistry, 2001, Kaila, Neelu et. al.
Isolation of glycopeptide-resistant enterococci from chicken in Japan.
score: 1.1151844, Antimicrobial agents and chemotherapy, 1998, Yoshimura, H et. al.
Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B 12 anaerobic pathway
score: 1.1150196, Bioorganic & Medicinal Chemistry, 2006, Santander, Patricio J. et. al.
ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes
score: 1.1150161, Bioorganic & Medicinal Chemistry, 1996, Wilde, Richard G. et. al.
Two-step efficient synthesis of 5-methyluridine via two thermostable nucleoside phosphorylase from Aeropyrum pernix
score: 1.1149972, Bioorganic & Medicinal Chemistry Letters, 2012, Zhu, Shaozhou et. al.
3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity
score: 1.1149818, European Journal of Medicinal Chemistry, 2004, Yogeeswari, Perumal et. al.
Safety and pharmacokinetics of multiple 750-milligram doses of intravenous levofloxacin in healthy volunteers.
score: 1.1149645, Antimicrobial agents and chemotherapy, 2001, Chow, A T et. al.
Effect of terbinafine on theophylline pharmacokinetics in healthy volunteers.
score: 1.11494, Antimicrobial agents and chemotherapy, 1998, Trépanier, E F; Nafziger, A N; Amsden, G W
Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method.
score: 1.1148779, Antimicrobial agents and chemotherapy, 2003, Martin, Anandi et. al.
Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage
score: 1.1148435, Bioorganic & Medicinal Chemistry Letters, 2003, Lauritsen, Anne et. al.
Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole.
score: 1.1147891, Antimicrobial agents and chemotherapy, 2006, Quan, Hua et. al.
Synthesis, anti- Trypanosoma cruzi activity and micelle interaction studies of bisguanylhydrazones analogous to pentamidine
score: 1.1147787, European Journal of Medicinal Chemistry, 2004, Borges, Márcia Narcizo et. al.
Synthesis and antifungal activity of coumarins and angular furanocoumarins
score: 1.1147613, Bioorganic & Medicinal Chemistry, 1999, Sardari, Soroush et. al.
In vivo efficacy of the novel aminoglycoside ACHN-490 in murine infection models.
score: 1.1147459, Antimicrobial agents and chemotherapy, 2011, Reyes, Noe; Aggen, James B; Kostrub, Corwin F
Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation
score: 1.1147444, Bioorganic & Medicinal Chemistry, 2012, Tanaka, Hiroshi et. al.
Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation
score: 1.1147444, Bioorganic & Medicinal Chemistry, 2012, Tanaka, Hiroshi et. al.
Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation
score: 1.1147444, Bioorganic & Medicinal Chemistry, 2012, Tanaka, Hiroshi et. al.
Extra copies of the Aspergillus fumigatus squalene epoxidase gene confer resistance to terbinafine: genetic approach to studying gene dose-dependent resistance to antifungals in A. fumigatus.
score: 1.1147311, Antimicrobial agents and chemotherapy, 2004, Liu, Wei et. al.
Activities of faropenem, an oral beta-lactam, against recent U.S. isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
score: 1.1147094, Antimicrobial agents and chemotherapy, 2002, Critchley, Ian A et. al.
In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir.
score: 1.1146256, Antimicrobial agents and chemotherapy, 1998, Seifer, M; Hamatake, R K; Colonno, R J; Standring, D N
Aptamer selection for the inhibition of cell adhesion with fibronectin as target
score: 1.1145801, Bioorganic & Medicinal Chemistry Letters, 2004, Ogawa, Atsushi et. al.
Efficacy of simulated cefditoren versus amoxicillin-clavulanate free concentrations in countering intrastrain ftsI gene diffusion in Haemophilus influenzae.
score: 1.1145476, Antimicrobial agents and chemotherapy, 2011, González, Natalia et. al.
The iron(II)/reductant ( DH 2)-induced activation of dioxygen for the demethylation of N-methylanilines: Reaction mimic for the cytochrome P-450/reductase system
score: 1.1144838, Bioorganic & Medicinal Chemistry, 1996, Hage, John P.; Schnelten, Joseph R.; Sawyer, Donald T.
Multilocus genotypes and DNA fingerprints Do not predict variation in azole resistance among clinical isolates of Candida albicans.
score: 1.1144181, Antimicrobial agents and chemotherapy, 1999, Cowen, L E et. al.
Cleavage of abasic sites in DNA by intercalator-amines
score: 1.1144065, Bioorganic & Medicinal Chemistry, 1999, Steullet, Vera; Edwards-Bennett, Sophia; Dixon, Dabney W.
Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides
score: 1.1143868, Bioorganic & Medicinal Chemistry, 2004, Masuda, Naoyuki et. al.
Free Energy Calculations on the Binding of Novel Thiolactomycin Derivatives to E. Coli Fatty Acid Synthase I
score: 1.1143785, Bioorganic & Medicinal Chemistry, 2012, Steinbrecher, Thomas; Case, David A.; Labahn, Andreas
Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond
score: 1.1143526, Bioorganic & Medicinal Chemistry Letters, 2012, Tanabe, Kazuhito; Asada, Takumi; Nishimoto, Sei-ichi
Biomolecular sensor based on fluorescence-labeled aptamer
score: 1.1143224, Bioorganic & Medicinal Chemistry Letters, 2006, Ozaki, Hiroaki et. al.
Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureus.
score: 1.1143215, Antimicrobial agents and chemotherapy, 2009, Renzoni, Adriana et. al.
Elucidation of structure–activity relationships for 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones
score: 1.1142972, Bioorganic & Medicinal Chemistry, 2004, Verma, Rajeshwar P.; Hansch, Corwin
Regioselective synthesis and Antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles
score: 1.1142911, Bioorganic & Medicinal Chemistry Letters, 2012, Lal, Kashmiri; Kumar, Ashwani; Pavan, M.S.; Kaushik, C.P.
Synthesis, antimicrobial activity and QSARs of new benzoxazine-3-ones
score: 1.1142528, European Journal of Medicinal Chemistry, 2006, Alper-Hayta, S. et. al.
The interaction of cisplatin with a human telomeric DNA sequence containing seventeen tandem repeats
score: 1.1142236, Bioorganic & Medicinal Chemistry Letters, 2013, Nguyen, Hanh T.Q.; Galea, Anne M.; Murray, Vincent
Synthesis and characterization of a tetranucleotide analogue containing alternating phosphonate-amide backbone linkages
score: 1.11414, Bioorganic & Medicinal Chemistry, 2001, Yu, Peilin et. al.
In Vitro Activities of Nine Antifungal Drugs against 81 Phialophora and Cyphellophora Isolates.
score: 1.1140669, Antimicrobial agents and chemotherapy, 2012, Feng, Peiying et. al.
Biochemical-genetic characterization of the chromosomally encoded extended-spectrum class A beta-lactamase from Rahnella aquatilis.
score: 1.113998, Antimicrobial agents and chemotherapy, 2001, Bellais, S et. al.
Discovery of a gene conferring multiple-aminoglycoside resistance in Escherichia coli.
score: 1.1139546, Antimicrobial agents and chemotherapy, 2010, Davis, Margaret A et. al.
Pyrrolidine carbamate nucleic acids: Synthesis and DNA binding studies
score: 1.1139253, Bioorganic & Medicinal Chemistry, 2003, Meena, ; Kumar, Vaijayanti A.
Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.
score: 1.1139169, Antimicrobial agents and chemotherapy, 2005, Didierjean, Joël et. al.
Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance.
score: 1.1138928, Antimicrobial agents and chemotherapy, 2011, LaMarre, Jacqueline M et. al.
Synthesis of 2′,3′-dideoxy-3′- C-(hydroxymethyl)-4′-thiopentofuranosyl nucleosides as potential antiviral agent
score: 1.1138918, Bioorganic & Medicinal Chemistry Letters, 1999, Ichikawa, Eiko; Yamamura, Shosuke; Kato, Kuniki
Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents
score: 1.1138832, Bioorganic & Medicinal Chemistry, 2006, Aboraia, Ahmed S. et. al.
Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin.
score: 1.1138187, Antimicrobial agents and chemotherapy, 2005, Kosowska, Klaudia et. al.
Synthesis of buprestins D, E, F, G and H; structural confirmation and biological testing of acyl glucoses from jewel beetles (Coleoptera: Buprestidae)
score: 1.1137693, Bioorganic & Medicinal Chemistry, 2009, Ryczek, Sebastian; Dettner, Konrad; Unverzagt, Carlo
Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3.
score: 1.113765, Antimicrobial agents and chemotherapy, 2004, Chau, Sze-Lok; Chu, Yiu-Wai; Houang, Elizabeth T S
Comparison of fungizone, Amphotec, AmBisome, and Abelcet for treatment of systemic murine cryptococcosis.
score: 1.1136713, Antimicrobial agents and chemotherapy, 1998, Clemons, K V; Stevens, D A
Functional characterization of Brucella melitensis NorMI, an efflux pump belonging to the multidrug and toxic compound extrusion family.
score: 1.1136331, Antimicrobial agents and chemotherapy, 2002, Braibant, Martine; Guilloteau, Laurence; Zygmunt, Michel S
Comparative efficacies of liposomal amikacin (MiKasome) plus oxacillin versus conventional amikacin plus oxacillin in experimental endocarditis induced by Staphylococcus aureus: microbiological and echocardiographic analyses.
score: 1.113619, Antimicrobial agents and chemotherapy, 1999, Xiong, Y Q; Kupferwasser, L I; Zack, P M; Bayer, A S
Broad-spectrum bactericidal activity of Ag(2)O-doped bioactive glass.
score: 1.113569, Antimicrobial agents and chemotherapy, 2002, Bellantone, Maria; Williams, Huw D; Hench, Larry L
In vivo selection for the directed evolution of l-rhamnulose aldolase from l-rhamnulose-1-phosphate aldolase (RhaD)
score: 1.1134761, Bioorganic & Medicinal Chemistry, 2007, Sugiyama, Masakazu et. al.
A comparison of the α-helix forming propensities and hydrogen bonding properties of serine phosphate and α-amino-γ-phosphonobutyric acid
score: 1.113438, Bioorganic & Medicinal Chemistry Letters, 1999, Liehr, Sebastian; Chenault, H.Keith
Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection.
score: 1.1134209, Antimicrobial agents and chemotherapy, 2002, Gish, R G et. al.
Identification of vat(E) in Enterococcus faecalis isolates from retail poultry and its transferability to Enterococcus faecium.
score: 1.1133889, Antimicrobial agents and chemotherapy, 2002, Simjee, S et. al.
New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents
score: 1.1133288, Bioorganic & Medicinal Chemistry, 2003, Dao, Vi-Thuy et. al.
Effects of sesquiterpenes and amino acid–sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages
score: 1.1132449, Bioorganic & Medicinal Chemistry, 2003, Matsuda, Hisashi et. al.
Incorporation of 2′-deoxy-5-(trifluoromethyl)uridine and 5-Cyano-2′-deoxyuridine into DNA
score: 1.1132376, Bioorganic & Medicinal Chemistry Letters, 2001, Markley, John C. et. al.
Decrease in the particle size of low-density lipoprotein (LDL) by oxidation
score: 1.1131685, Bioorganic & Medicinal Chemistry Letters, 2005, Hidaka, Atsuko et. al.
Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria.
score: 1.1131399, Antimicrobial agents and chemotherapy, 2001, Krishna, S et. al.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
score: 1.1130546, Antimicrobial agents and chemotherapy, 1998, Gniadkowski, M et. al.
Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects
score: 1.113029, Bioorganic & Medicinal Chemistry, 2003, Wilkinson, Douglas E et. al.
Addition of rifampin to standard therapy for treatment of native valve infective endocarditis caused by Staphylococcus aureus.
score: 1.1130069, Antimicrobial agents and chemotherapy, 2008, Riedel, David J; Weekes, Elizabeth; Forrest, Graeme N
Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives
score: 1.1130055, Bioorganic & Medicinal Chemistry Letters, 2013, Nagarajan, Shunmugam et. al.
Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum.
score: 1.1129754, Antimicrobial agents and chemotherapy, 1999, Gangneux, J P et. al.
Impact of the aryl substituent kind and distance from pyrimido[2,1- f]purindiones on the adenosine receptor selectivity and antagonistic properties
score: 1.1129705, European Journal of Medicinal Chemistry, 2003, Drabczyńska, Anna et. al.
Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis.
score: 1.1129162, Antimicrobial agents and chemotherapy, 2002, Sarisky, Robert T et. al.
Selection of a buried salt bridge by phage display
score: 1.1128794, Bioorganic & Medicinal Chemistry Letters, 2009, Vagt, Toni et. al.
Study on the compounds containing 19F and 10B atoms in a single molecule for the application to MRI and BNCT
score: 1.1128663, Bioorganic & Medicinal Chemistry, 2006, Hattori, Yoshihide et. al.
Influence of macrolide susceptibility on efficacies of clarithromycin and azithromycin against Streptococcus pneumoniae in a murine lung infection model.
score: 1.1128149, Antimicrobial agents and chemotherapy, 2003, Hoffman, Holly L et. al.
Cyclodextrin trimers as receptors for arranging ester and catalyst at optimized location to achieve enhancement of hydrolytic activity
score: 1.1127874, Bioorganic & Medicinal Chemistry Letters, 2004, Nakajima, Hiroki et. al.
Trichloroacetaldehyde modified oligonucleotides
score: 1.1127387, Bioorganic & Medicinal Chemistry Letters, 2005, Gaus, Hans et. al.
Activities of dalbavancin in vitro and in a rabbit model of experimental endocarditis due to Staphylococcus aureus with or without reduced susceptibility to vancomycin and teicoplanin.
score: 1.1127259, Antimicrobial agents and chemotherapy, 2004, Lefort, Agnès et. al.
Efficacy of recombinant gamma interferon for treatment of systemic cryptococcosis in SCID mice.
score: 1.1126494, Antimicrobial agents and chemotherapy, 2001, Clemons, K V; Lutz, J E; Stevens, D A
Cefoxitin as an alternative to carbapenems in a murine model of urinary tract infection due to Escherichia coli harboring CTX-M-15-type extended-spectrum β-lactamase.
score: 1.1125318, Antimicrobial agents and chemotherapy, 2012, Lepeule, Raphaël et. al.
Synthesis and biological evaluation of novel fluoro and iodo quinoline carboxamides as potential ligands of NK-3 receptors for in vivo imaging studies
score: 1.1124932, Bioorganic & Medicinal Chemistry, 2004, Bennacef, Idriss et. al.
Metallo-beta-lactamase production by Pseudomonas otitidis: a species-related trait.
score: 1.1124756, Antimicrobial agents and chemotherapy, 2011, Thaller, Maria Cristina et. al.
Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole.
score: 1.1124635, Antimicrobial agents and chemotherapy, 2011, Kuipers, Saskia et. al.
The preparation and bioactivities of (−)-isovelleral 1,2
score: 1.1124335, Bioorganic & Medicinal Chemistry, 1997, Jonassohn, Mikael et. al.
rpoB mutations in Streptococcus mitis clinical isolates resistant to rifampin.
score: 1.1123096, Antimicrobial agents and chemotherapy, 2004, Achour, Wafa et. al.
Small Molecule Bromodomain Inhibitors-1:Extending the Druggable Genome
score: 1.1122992, Progress in Medicinal Chemistry, 2012, Chung, Chun-wa
Comparative in vitro activities of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium spp., including 117 P. acnes isolates.
score: 1.1122597, Antimicrobial agents and chemotherapy, 2006, Goldstein, Ellie J C et. al.
Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli.
score: 1.1122432, Antimicrobial agents and chemotherapy, 2010, López, Eduardo L et. al.
A dumbbell molecular beacon for the specific recognition of nucleic acids
score: 1.1122179, Bioorganic & Medicinal Chemistry Letters, 2010, Lv, Cong; Yu, LiLi; Wang, Jie; Tang, XinJing
NDM-1-producing Klebsiella pneumoniae in Mauritius.
score: 1.1122158, Antimicrobial agents and chemotherapy, 2012, Poirel, Laurent et. al.
30S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli.
score: 1.1121853, Antimicrobial agents and chemotherapy, 2002, Mehta, Roopal; Champney, W Scott
A host-rotaxane derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide
score: 1.1121503, Bioorganic & Medicinal Chemistry Letters, 2007, Zhu, Jing et. al.
Molecular analysis of incHI1 antimicrobial resistance plasmids from Salmonella serovar Typhi strains associated with typhoid fever.
score: 1.1120974, Antimicrobial agents and chemotherapy, 2003, Wain, John et. al.
Pharmacokinetics and safety of voriconazole following intravenous- to oral-dose escalation regimens.
score: 1.112076, Antimicrobial agents and chemotherapy, 2002, Purkins, L et. al.
Environmental KPC-producing Escherichia coli isolates in Portugal.
score: 1.1120298, Antimicrobial agents and chemotherapy, 2012, Poirel, Laurent et. al.
Rapid detection of mutations in the human-derived Pneumocystis carinii dihydropteroate synthase gene associated with sulfa resistance.
score: 1.111997, Antimicrobial agents and chemotherapy, 2001, Ma, L; Kovacs, J A
Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine.
score: 1.1119421, Antimicrobial agents and chemotherapy, 2011, Satlin, Michael J et. al.
Prospective, observational study of voriconazole therapeutic drug monitoring among lung transplant recipients receiving prophylaxis: factors impacting levels of and associations between serum troughs, efficacy, and toxicity.
score: 1.1119367, Antimicrobial agents and chemotherapy, 2012, Mitsani, Dimitra et. al.
Efficacy of trovafloxacin, a new quinolone antibiotic, in experimental staphylococcal endocarditis due to oxacillin-resistant strains.
score: 1.1119333, Antimicrobial agents and chemotherapy, 1998, Bayer, A S; Li, C; Ing, M
Synthesis of 21,21-Difluoro-3β-hydroxy-20-methylpregna-5,20-diene and 5,16,20-Triene as potential inhibitors of steroid C 17(20) lyase
score: 1.1118929, Bioorganic & Medicinal Chemistry, 2003, Weintraub, Philip M et. al.
Effect of drug concentration on emergence of macrolide resistance in Mycobacterium avium.
score: 1.1118175, Antimicrobial agents and chemotherapy, 2001, Nash, K A
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds
score: 1.1118153, European Journal of Medicinal Chemistry, 2004, Vashishtha, Sarvesh C et. al.
Clinical correlation of the CLSI susceptibility breakpoint for piperacillin- tazobactam against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella species.
score: 1.1117513, Antimicrobial agents and chemotherapy, 2006, Gavin, Patrick J et. al.
Influence of clarithromycin on early atherosclerotic lesions after Chlamydia pneumoniae infection in a rabbit model.
score: 1.1117408, Antimicrobial agents and chemotherapy, 2002, Fong, Ignatius W et. al.
Characterization of resistance to the protease inhibitor GS-9451 in hepatitis C virus-infected patients.
score: 1.1116882, Antimicrobial agents and chemotherapy, 2012, Dvory-Sobol, Hadas et. al.
Therapeutic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H275Y neuraminidase mutation.
score: 1.1116729, Antimicrobial agents and chemotherapy, 2012, Abed, Yacine; Pizzorno, Andrés; Boivin, Guy
Acquisition of chloramphenicol resistance by the linearization and integration of the entire staphylococcal plasmid pC194 into the chromosome of Streptococcus pneumoniae.
score: 1.1116266, Antimicrobial agents and chemotherapy, 2000, Widdowson, C A; Adrian, P V; Klugman, K P
The impact of carbon–hydrogen bond dissociation energies on the prediction of the cytochrome P450 mediated major metabolic site of drug-like compounds
score: 1.1115919, European Journal of Medicinal Chemistry, 2012, Drew, Kurt L.M.; Reynisson, Jóhannes
The impact of carbon–hydrogen bond dissociation energies on the prediction of the cytochrome P450 mediated major metabolic site of drug-like compounds
score: 1.1115919, European Journal of Medicinal Chemistry, 2012, Drew, Kurt L.M.; Reynisson, Jóhannes
Resistance to quinupristin-dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus.
score: 1.1115805, Antimicrobial agents and chemotherapy, 2002, Malbruny, Brigitte et. al.
Antibacterial and antifungal activity of acyclic and macrocyclic uracil derivatives with quaternized nitrogen atoms in spacers
score: 1.1115752, European Journal of Medicinal Chemistry, 2006, Semenov, V.E. et. al.
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
score: 1.1115566, Antimicrobial agents and chemotherapy, 2011, Tijet, Nathalie et. al.
2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase
score: 1.1115503, Bioorganic & Medicinal Chemistry Letters, 2004, Prasad, C.V.C. et. al.
Cytosporone E: racemic synthesis and preliminary antibacterial testing
score: 1.1115277, Bioorganic & Medicinal Chemistry, 2005, Hall, Jeffrey D. et. al.
Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques.
score: 1.1114605, Antimicrobial agents and chemotherapy, 2012, Moss, John A et. al.
Synthesis and comparative assessment of a labeled RGD peptide bearing two different 99mTc-tricarbonyl chelators for potential use as targeted radiopharmaceutical
score: 1.1114453, Bioorganic & Medicinal Chemistry, 2012, Psimadas, Dimitrios et. al.
Synthesis and properties of α- and β-oligodeoxynucleotides containing α- and β-1-(2-O- methyl- d-arabinofuranosyl)thymine
score: 1.1114407, Bioorganic & Medicinal Chemistry, 1996, Gotfredsen, Charlotte H. et. al.
Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine
score: 1.1113114, Bioorganic & Medicinal Chemistry Letters, 2001, Mitchell, Deanna J. et. al.
Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008.
score: 1.1112993, Antimicrobial agents and chemotherapy, 2008, Sheu, Tiffany G et. al.
Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H 3 receptor antagonists
score: 1.1112374, Bioorganic & Medicinal Chemistry, 2004, Mikó, Tibor et. al.
Carbohydrate-conjugated porphyrin dimers: Synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy
score: 1.111233, Bioorganic & Medicinal Chemistry, 2013, Garcia, Guillaume et. al.
Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance.
score: 1.1112119, Antimicrobial agents and chemotherapy, 2002, Low, D E et. al.
Stability of colistin and colistin methanesulfonate in aqueous media and plasma as determined by high-performance liquid chromatography.
score: 1.1112035, Antimicrobial agents and chemotherapy, 2003, Li, Jian et. al.
Display of functional beta-lactamase inhibitory protein on the surface of M13 bacteriophage.
score: 1.1111462, Antimicrobial agents and chemotherapy, 1998, Huang, W; Petrosino, J; Palzkill, T
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa.
score: 1.1111146, Antimicrobial agents and chemotherapy, 2011, Muller, Cédric; Plésiat, Patrick; Jeannot, Katy
Photo-Control of nitric oxide synthase activity using a caged isoform specific inhibitor
score: 1.1110828, Bioorganic & Medicinal Chemistry, 2002, Montgomery, Heather J. et. al.
Chemical–biological interactions in human
score: 1.1110821, Bioorganic & Medicinal Chemistry, 2005, Verma, Rajeshwar P. et. al.
Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin.
score: 1.1110695, Antimicrobial agents and chemotherapy, 2004, Raad, Issam I et. al.
Fosfomycin reduces CD15s-related antigen expression of Streptococcus pyogenes.
score: 1.1110504, Antimicrobial agents and chemotherapy, 1998, Hirota, K et. al.
In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis?
score: 1.1110491, Antimicrobial agents and chemotherapy, 2011, Togni, Giuseppe et. al.
Antibacterial properties of gemifloxacin and trovafloxacin in urine ex vivo: phase I study.
score: 1.1109789, Antimicrobial agents and chemotherapy, 2001, García-Calvo, G et. al.
Increasing bacterial resistance in pediatric acute conjunctivitis (1997-1998).
score: 1.1109506, Antimicrobial agents and chemotherapy, 2000, Block, S L et. al.
A new method for assessing metronidazole susceptibility of Giardia lamblia trophozoites.
score: 1.1109365, Antimicrobial agents and chemotherapy, 1999, Sousa, M C; Poiares-Da-Silva, J
Role of penicillin-binding proteins in the initiation of the AmpC beta-lactamase expression in Enterobacter cloacae.
score: 1.1109294, Antimicrobial agents and chemotherapy, 2000, Pfeifle, D; Janas, E; Wiedemann, B
Oligonucleotide microarrays with stem–loop probes: Enhancing the hybridization of nucleic acids for sensitive analysis
score: 1.1108285, Bioorganic & Medicinal Chemistry Letters, 2008, Mahajan, Shweta et. al.
Pharmacophoric features of nucleosidic HIV-1RT inhibitors
score: 1.1107161, Bioorganic & Medicinal Chemistry, 2003, Yadav, Arpita; Singh, Sanjeev Kumar
tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance.
score: 1.1106958, Antimicrobial agents and chemotherapy, 2002, Hasman, Henrik; Aarestrup, Frank M
Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula.
score: 1.1105959, Antimicrobial agents and chemotherapy, 2011, Bergen, Phillip J et. al.
Multiresistant Uropathogenic Escherichia coli from a Region in India Where Urinary Tract Infections Are Endemic: Genotypic and Phenotypic Characteristics of Sequence Type 131 Isolates of the CTX-M-15 Extended-Spectrum-β-Lactamase-Producing Lineage.
score: 1.1104681, Antimicrobial agents and chemotherapy, 2012, Hussain, Arif et. al.
Species-specific differences in the susceptibilities of biofilms formed by Candida bloodstream isolates to echinocandin antifungals.
score: 1.1104663, Antimicrobial agents and chemotherapy, 2007, Choi, Hyun Woo et. al.
Characterization of a Binding Site for Template Competitive Inhibitors of HIV-1 Reverse Transcriptase Using Photolabeling Derivatives
score: 1.1104635, Bioorganic & Medicinal Chemistry, 2002, Lin, Weiying; Li, Ke; Doughty, Michael B.
Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins
score: 1.1104197, Bioorganic & Medicinal Chemistry Letters, 2006, Takahashi, Teruki et. al.
A case of New Delhi metallo-β-lactamase 1 (NDM-1)-producing Klebsiella pneumoniae with putative secondary transmission from the Balkan region in the Netherlands.
score: 1.1103905, Antimicrobial agents and chemotherapy, 2012, Halaby, Teysir et. al.
Dissemination of pCT-like IncK plasmids harboring CTX-M-14 extended-spectrum β-lactamase among clinical Escherichia coli isolates in the United Kingdom.
score: 1.1103712, Antimicrobial agents and chemotherapy, 2012, Dhanji, Hiran et. al.
Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3- d]-pyrimidines
score: 1.1103439, Bioorganic & Medicinal Chemistry, 1997, Quintela, JoséM. et. al.
Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3- d]-pyrimidines
score: 1.1103439, Bioorganic & Medicinal Chemistry, 1997, Quintela, JoséM. et. al.
Decreased susceptibility to cefepime in a clinical strain of Escherichia coli related to plasmid- and integron-encoded OXA-30 beta-lactamase.
score: 1.1103333, Antimicrobial agents and chemotherapy, 2003, Dubois, Véronique et. al.
Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-β1 protein
score: 1.1103105, Bioorganic & Medicinal Chemistry Letters, 2008, Kang, Jonghoon et. al.
Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases
score: 1.110288, European Journal of Medicinal Chemistry, 2012, Coulibaly, Wacothon Karime et. al.
Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases
score: 1.110288, European Journal of Medicinal Chemistry, 2012, Coulibaly, Wacothon Karime et. al.
Assessing the ability of a short fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallization
score: 1.1102612, Bioorganic & Medicinal Chemistry Letters, 2010, Chaytor, Jennifer L.; Ben, Robert N.
Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives
score: 1.1102278, European Journal of Medicinal Chemistry, 2004, Amir, Mohd; Shikha, Kumar
In vitro activity of a new oral triazole, BMS-207147 (ER-30346)
score: 1.1102241, Antimicrobial agents and chemotherapy, 1998, Fung-Tomc, J C; Huczko, E; Minassian, B; Bonner, D P
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.
score: 1.1101742, Antimicrobial agents and chemotherapy, 2000, Iyobe, S et. al.
Accumulation of amphotericin B in human macrophages enhances activity against Aspergillus fumigatus conidia: quantification of conidial kill at the single-cell level.
score: 1.110154, Antimicrobial agents and chemotherapy, 1998, Jahn, B; Rampp, A; Dick, C; Jahn, A; Palmer, M; Bhakdi, S
Role of common blaOXA-24/OXA-40-carrying platforms and plasmids in the spread of OXA-24/OXA-40 among Acinetobacter species clinical isolates.
score: 1.1100856, Antimicrobial agents and chemotherapy, 2012, Grosso, Filipa et. al.
Stereochemical effects of all-hydrocarbon tethers in i, i+4 stapled peptides
score: 1.1100681, Bioorganic & Medicinal Chemistry Letters, 2009, Kim, Young-Woo; Verdine, Gregory L.
Photocontrol of nitric oxide production in cell culture using a caged isoform selective inhibitor
score: 1.110039, Bioorganic & Medicinal Chemistry, 2005, Perdicakis, Basil et. al.
Clonal dissemination and mupA gene polymorphism of mupirocin-resistant Staphylococcus aureus isolates from long-term-care facilities in South Korea.
score: 1.1100093, Antimicrobial agents and chemotherapy, 2006, Yoo, Jae Il et. al.
Activities of atazanavir (BMS-232632) against a large panel of human immunodeficiency virus type 1 clinical isolates resistant to one or more approved protease inhibitors.
score: 1.1099602, Antimicrobial agents and chemotherapy, 2003, Colonno, Richard J et. al.
Design and synthesis of a photocleavable biotin-linker for the photoisolation of ligand–receptor complexes based on the photolysis of 8-quinolinyl sulfonates in aqueous solution
score: 1.1098921, Bioorganic & Medicinal Chemistry, 2009, Aoki, Shin et. al.
N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity
score: 1.1098896, Bioorganic & Medicinal Chemistry, 2003, Vandevoorde, Séverine et. al.
Horseradish peroxidase-mediated aerobic and anaerobic oxidations of 3-alkylindoles
score: 1.1097453, Bioorganic & Medicinal Chemistry, 2005, Ling, Ke-Qing; Sayre, Lawrence M.
Surveillance for antiviral-agent-resistant herpes simplex virus in the general population with recurrent herpes labialis.
score: 1.109728, Antimicrobial agents and chemotherapy, 2002, Bacon, Teresa H et. al.
Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus.
score: 1.1097121, Antimicrobial agents and chemotherapy, 2005, Nagura, Jun et. al.
Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995.
score: 1.1097047, Antimicrobial agents and chemotherapy, 1998, Chu, Y W et. al.
Three-dimensional pharmacophore hypotheses for the locust neuronal octopamine receptor (OAR3). Part 2: agonists
score: 1.1097006, Bioorganic & Medicinal Chemistry, 1999, Hirashima, Akinori et. al.
Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers.
score: 1.1096706, Antimicrobial agents and chemotherapy, 2011, Luganini, Anna et. al.
Dihydroxybergamottin Caproate as a Potent and Stable CYP3A4 Inhibitor
score: 1.1096614, Bioorganic & Medicinal Chemistry, 2002, Ohta, Tomihisa et. al.
Synthesis of octadecylamine-retinoic acid conjugate for enhanced cytotoxic effects of 5-FU using LDL targeted nanostructured lipid carriers
score: 1.1096401, European Journal of Medicinal Chemistry, 2012, Varshosaz, Jaleh et. al.
Synthesis of octadecylamine-retinoic acid conjugate for enhanced cytotoxic effects of 5-FU using LDL targeted nanostructured lipid carriers
score: 1.1096401, European Journal of Medicinal Chemistry, 2012, Varshosaz, Jaleh et. al.
In vitro activity and in vivo efficacy of posaconazole in treatment of murine infections by different isolates of the Aspergillus terreus complex.
score: 1.1094343, Antimicrobial agents and chemotherapy, 2011, Salas, Valentina et. al.
13,28-Epoxy triterpenoid saponins from Ardisia japonica selectively inhibit proliferation of liver cancer cells without affecting normal liver cells
score: 1.1094324, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Qin et. al.
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.
score: 1.1094237, Antimicrobial agents and chemotherapy, 2005, Ballard, S A; Grabsch, E A; Johnson, P D R; Grayson, M L
Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers.
score: 1.1094204, Antimicrobial agents and chemotherapy, 2004, Rossignol, Daniel P et. al.
DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases
score: 1.1094112, Bioorganic & Medicinal Chemistry, 2012, San Pedro, Joanna Maria N. et. al.
DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases
score: 1.1094112, Bioorganic & Medicinal Chemistry, 2012, San Pedro, Joanna Maria N. et. al.
Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes
score: 1.1094107, European Journal of Medicinal Chemistry, 2010, Liu, Yun-Jun et. al.
Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter.
score: 1.1094063, Antimicrobial agents and chemotherapy, 2011, Albarrag, Ahmed M et. al.
Determinants of ceftazidime clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis.
score: 1.1093949, Antimicrobial agents and chemotherapy, 2000, Matzke, G R; Frye, R F; Joy, M S; Palevsky, P M
Pharmacological and patient-specific response determinants in patients with hospital-acquired pneumonia treated with tigecycline.
score: 1.109387, Antimicrobial agents and chemotherapy, 2012, Bhavnani, Sujata M et. al.
Use of a rapid throughput in vivo screen to investigate inhibitors of eukaryotic topoisomerase II enzymes.
score: 1.109361, Antimicrobial agents and chemotherapy, 1998, Hammonds, T R; Maxwell, A; Jenkins, J R
Crystallographic studies on two bioisosteric analogues, N-acetyl-β- d-glucopyranosylamine and N-trifluoroacetyl-β- d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
score: 1.1093099, Bioorganic & Medicinal Chemistry, 2006, Anagnostou, Eleni et. al.
Pharmacodynamic functions: a multiparameter approach to the design of antibiotic treatment regimens.
score: 1.1091766, Antimicrobial agents and chemotherapy, 2004, Regoes, Roland R et. al.
Synthesis, hydroxyl radical production and cytotoxicity of analogues of bleomycin
score: 1.1090841, Bioorganic & Medicinal Chemistry, 2000, Highfield, Jackie A. et. al.
Nucleic acid controlled catalysts of carboxylic esters hydrolysis
score: 1.1090396, Bioorganic & Medicinal Chemistry Letters, 2008, Kovács, János; Mokhir, Andriy
Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB
score: 1.1088764, Bioorganic & Medicinal Chemistry, 2010, Seshime, Yasuyo et. al.
Staphylococcus aureus strains that are hypersusceptible to resistance gene transfer from enterococci.
score: 1.1088313, Antimicrobial agents and chemotherapy, 2007, Sung, Julia M-L; Lindsay, Jodi A
Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES.
score: 1.1088059, Antimicrobial agents and chemotherapy, 2003, Pastore, Cristina et. al.
Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.
score: 1.1087167, Antimicrobial agents and chemotherapy, 2006, Bishop, Emma et. al.
Potent efficacy of entecavir (BMS-200475) in a duck model of hepatitis B virus replication.
score: 1.1086967, Antimicrobial agents and chemotherapy, 2002, Marion, Patricia L et. al.
Programmable oligomers targeting 5′-GGGG-3′ in the minor groove of DNA and NF-κB binding inhibition
score: 1.1086915, Bioorganic & Medicinal Chemistry, 2007, Chenoweth, David M. et. al.
Macrolide resistance in Streptococcus pneumoniae in Hong Kong.
score: 1.1086905, Antimicrobial agents and chemotherapy, 2001, Ip, M; Lyon, D J; Yung, R W; Chan, C; Cheng, A F
The LisRK signal transduction system determines the sensitivity of Listeria monocytogenes to nisin and cephalosporins.
score: 1.1086527, Antimicrobial agents and chemotherapy, 2002, Cotter, Paul D; Guinane, Caitriona M; Hill, Colin
Caspofungin in combination with amphotericin B against Candida glabrata.
score: 1.1085948, Antimicrobial agents and chemotherapy, 2005, Barchiesi, Francesco et. al.
Recent progress with FKBP-derived destabilizing domains
score: 1.1085436, Bioorganic & Medicinal Chemistry Letters, 2008, Chu, Bernard W. et. al.
Synthesis of 2′- O-modified adenosine building blocks and application for RNA interference
score: 1.1085304, Bioorganic & Medicinal Chemistry, 2008, Odadzic, Dalibor et. al.
Antimicrobial peptide therapeutics for cystic fibrosis.
score: 1.1085245, Antimicrobial agents and chemotherapy, 2005, Zhang, Lijuan et. al.
Data mining validation of fluconazole breakpoints established by the European Committee on Antimicrobial Susceptibility Testing.
score: 1.1085066, Antimicrobial agents and chemotherapy, 2009, Cuesta, Isabel et. al.
Comparison of the pharmacodynamics of meropenem in patients with ventilator-associated pneumonia following administration by 3-hour infusion or bolus injection.
score: 1.1084992, Antimicrobial agents and chemotherapy, 2005, Jaruratanasirikul, Sutep et. al.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
score: 1.1084173, Antimicrobial agents and chemotherapy, 2011, Poirel, Laurent; Bonnin, Rémy A; Nordmann, Patrice
In vivo imaging of bioluminescent Escherichia coli in a cutaneous wound infection model for evaluation of an antibiotic therapy.
score: 1.1084046, Antimicrobial agents and chemotherapy, 2004, Jawhara, Samir; Mordon, Serge
A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions
score: 1.1083339, Bioorganic & Medicinal Chemistry Letters, 2001, Nagatsugi, Fumi et. al.
Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment.
score: 1.1082341, Antimicrobial agents and chemotherapy, 2005, Micek, Scott T et. al.
First enantiodivergent Baeyer–Villiger oxidation by recombinant whole-Cells expressing two monooxygenases from Brevibacterium
score: 1.108144, Bioorganic & Medicinal Chemistry Letters, 2003, Mihovilovic, Marko D et. al.
Selection of clinically relevant protease inhibitor-resistant viruses using the genotype 2a hepatitis C virus infection system.
score: 1.1081036, Antimicrobial agents and chemotherapy, 2011, Cheng, Guofeng et. al.
Hybrids of Ravuconazole: Synthesis and biological Evaluation
score: 1.1081015, European Journal of Medicinal Chemistry, 2012, Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Synthesis and anticancer activity of lipophilic platinum(II) complexes of 3,5-diisopropylsalicylate
score: 1.1079933, European Journal of Medicinal Chemistry, 2008, Yu, Yao et. al.
Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors.
score: 1.1079689, Antimicrobial agents and chemotherapy, 2012, McFadden, Karyn et. al.
Emergence and dissemination of BEL-1-producing Pseudomonas aeruginosa isolates in Belgium.
score: 1.1078962, Antimicrobial agents and chemotherapy, 2007, Bogaerts, Pierre et. al.
Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli.
score: 1.1078962, Antimicrobial agents and chemotherapy, 2006, Orlén, Hanna; Hughes, Diarmaid
Synthesis and biological activity evaluation of emodin quaternary ammonium salt derivatives as potential anticancer agents
score: 1.1078382, European Journal of Medicinal Chemistry, 2012, Wang, Wenfeng et. al.
Synthesis and biological activity evaluation of emodin quaternary ammonium salt derivatives as potential anticancer agents
score: 1.1078382, European Journal of Medicinal Chemistry, 2012, Wang, Wenfeng et. al.
Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation
score: 1.107829, Bioorganic & Medicinal Chemistry, 2006, Tachi, Yukihiro et. al.
Polymer-bound N-hydroxysuccinimide esters: A column-free fluorescent-labeling method
score: 1.1076135, Bioorganic & Medicinal Chemistry Letters, 1999, Katoh, Miho; Sodeoka, Mikiko
Prominence of an O75 clonal group (clonal complex 14) among non-ST131 fluoroquinolone-resistant Escherichia coli causing extraintestinal infections in humans and dogs in Australia.
score: 1.1075876, Antimicrobial agents and chemotherapy, 2012, Platell, Joanne L et. al.
Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity
score: 1.1075408, Bioorganic & Medicinal Chemistry, 2005, Ferlin, Maria Grazia et. al.
Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus.
score: 1.1075278, Antimicrobial agents and chemotherapy, 2003, Zhao, Xilin et. al.
Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes.
score: 1.107492, Antimicrobial agents and chemotherapy, 2004, Hallett, Rachel L et. al.
Enhancement of the mexAB-oprM efflux pump expression by a quorum-sensing autoinducer and its cancellation by a regulator, MexT, of the mexEF-oprN efflux pump operon in Pseudomonas aeruginosa.
score: 1.1074796, Antimicrobial agents and chemotherapy, 2004, Maseda, Hideaki et. al.
10-23 DNAzyme modified with (2′ R)- and (2′ S)-2′-deoxy-2′- C-methyluridine in the catalytic core
score: 1.1074641, Bioorganic & Medicinal Chemistry Letters, 2010, Robaldo, Laura; Montserrat, Javier M.; Iribarren, Adolfo M.
Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers.
score: 1.1074518, Antimicrobial agents and chemotherapy, 2011, Bulitta, J B et. al.
Pharmacokinetics and tolerability of gemifloxacin (SB-265805) after administration of single oral doses to healthy volunteers.
score: 1.1074471, Antimicrobial agents and chemotherapy, 2000, Allen, A et. al.
Novel polycyclic ‘cage’-1,2-diamines as potential anti-tuberculosis agents
score: 1.1073516, European Journal of Medicinal Chemistry, 2012, Onajole, Oluseye K. et. al.
Novel polycyclic ‘cage’-1,2-diamines as potential anti-tuberculosis agents
score: 1.1073516, European Journal of Medicinal Chemistry, 2012, Onajole, Oluseye K. et. al.
Structure-Activity Relationships among the Kanamycin Aminoglycosides: Role of Ring I Hydroxyl and Amino Groups.
score: 1.1073408, Antimicrobial agents and chemotherapy, 2012, Salian, Sumantha et. al.
In vitro antifungal activity of nikkomycin Z in combination with fluconazole or itraconazole.
score: 1.1073194, Antimicrobial agents and chemotherapy, 1999, Li, R K; Rinaldi, M G
A novel cell-associated protection assay demonstrates the ability of certain antibiotics to protect ocular surface cell lines from subsequent clinical Staphylococcus aureus challenge.
score: 1.1071657, Antimicrobial agents and chemotherapy, 2011, Wingard, J B et. al.
Effects of miltefosine and other alkylphosphocholines on human intestinal parasite Entamoeba histolytica.
score: 1.1069988, Antimicrobial agents and chemotherapy, 2001, Seifert, K et. al.
Vancomycin analogs: Seeking improved binding of d-Ala- d-Ala and d-Ala- d-Lac peptides by side-chain and backbone modifications
score: 1.1069675, Bioorganic & Medicinal Chemistry, 2009, Leung, Siegfried S.F. et. al.
Resistance to autolysis in vancomycin-selected Staphylococcus aureus isolates precedes vancomycin-intermediate resistance.
score: 1.1069516, Antimicrobial agents and chemotherapy, 2003, Boyle-Vavra, Susan; Challapalli, Mamatha; Daum, Robert S
Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins
score: 1.1069255, Bioorganic & Medicinal Chemistry, 2005, Yang, Qing et. al.
In Vitro susceptibility of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus to a new antimicrobial, copper silicate.
score: 1.1068833, Antimicrobial agents and chemotherapy, 2007, Carson, Kerry C et. al.
Density-functional theory studies on standard electrode potentials of half reaction for l-adrenaline and adrenalinequinone
score: 1.1068271, Bioorganic & Medicinal Chemistry Letters, 2005, Song, Yuanzhi et. al.
Control of function of a small peptide by a protein
score: 1.1068119, Bioorganic & Medicinal Chemistry Letters, 2006, Tanaka, Fujie; Fuller, Roberta
Extended-spectrum-cephalosporin resistance in Salmonella enterica isolates of animal origin.
score: 1.1068071, Antimicrobial agents and chemotherapy, 2004, Gray, Jeffrey T et. al.
In vitro activities in new oxazolidinone antimicrobial agents against enterococci.
score: 1.1067811, Antimicrobial agents and chemotherapy, 1996, Eliopoulos, G M; Wennersten, C B; Gold, H S; Moellering, R C
Mechanisms of resistance to quinupristin-dalfopristin among isolates of Enterococcus faecium from animals, raw meat, and hospital patients in Western Europe.
score: 1.1067561, Antimicrobial agents and chemotherapy, 2000, Soltani, M; Beighton, D; Philpott-Howard, J; Woodford, N
Incidence of high-level evernimicin resistance in Enterococcus faecium among food animals and humans.
score: 1.1067047, Antimicrobial agents and chemotherapy, 2002, Aarestrup, Frank Møller; McNicholas, Paul M
In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection.
score: 1.1066885, Antimicrobial agents and chemotherapy, 2012, Hengzhuang, Wang et. al.
Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.
score: 1.106646, Antimicrobial agents and chemotherapy, 2011, Brossier, F et. al.
Novel antiallergic and antiinflammatory agents. Part I: Synthesis and pharmacology of glycolic amide derivatives
score: 1.1066454, Bioorganic & Medicinal Chemistry, 1998, Ban, Masakazu et. al.
In vitro activity of caspofungin combined with sulfamethoxazole against clinical isolates of Aspergillus spp.
score: 1.1066354, Antimicrobial agents and chemotherapy, 2004, Yekutiel, Aya; Shalit, Itamar; Shadkchan, Yona; Osherov, Nir
Population pharmacokinetics of Arbekacin in patients infected with methicillin-resistant Staphylococcus aureus.
score: 1.1065093, Antimicrobial agents and chemotherapy, 2006, Tanigawara, Yusuke et. al.
In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B.
score: 1.1065073, Antimicrobial agents and chemotherapy, 2005, Manavathu, Elias K et. al.
Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.
score: 1.1064967, Antimicrobial agents and chemotherapy, 2002, Lawrence, Laura E et. al.
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway
score: 1.1064457, Bioorganic & Medicinal Chemistry, 2005, Cheng, Heng et. al.
Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis.
score: 1.1064243, Antimicrobial agents and chemotherapy, 2001, Saiman, L et. al.
Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate
score: 1.1064072, Bioorganic & Medicinal Chemistry Letters, 2010, Zhang, Yuanqing et. al.
Lack of cell wall peptidoglycan versus penicillin sensitivity: new insights into the chlamydial anomaly.
score: 1.1063756, Antimicrobial agents and chemotherapy, 1999, Ghuysen, J M; Goffin, C
Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries
score: 1.1063552, European Journal of Medicinal Chemistry, 2002, Berkan, Öcal et. al.
Microarray-based label-free detection of RNA using bispyrene-modified 2′- O-methyl oligoribonucleotide as capture and detection probe
score: 1.1063383, Bioorganic & Medicinal Chemistry Letters, 2008, Sakamoto, Takashi; Kobori, Akio; Murakami, Akira
In vitro activities of co-amoxiclav at concentrations achieved in human serum against the resistant subpopulation of heteroresistant Staphylococcus aureus: a controlled study with vancomycin.
score: 1.1063009, Antimicrobial agents and chemotherapy, 1998, Prieto, J et. al.
Towards more chemically robust polymer-supported chiral catalysts for the reactions of aldehydes with dialkylzincs
score: 1.1062075, Bioorganic & Medicinal Chemistry Letters, 2002, Kell, Roger J. et. al.
Analysis of ciprofloxacin activity against Streptococcus pneumoniae after 10 years of use in the United States.
score: 1.106047, Antimicrobial agents and chemotherapy, 2000, Sahm, D F; Peterson, D E; Critchley, I A; Thornsberry, C
Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro.
score: 1.1060425, Antimicrobial agents and chemotherapy, 2002, Tremblay, Cécile L et. al.
Impact of cefepime therapy on mortality among patients with bloodstream infections caused by extended-spectrum-β-lactamase-producing Klebsiella pneumoniae and Escherichia coli.
score: 1.1060339, Antimicrobial agents and chemotherapy, 2012, Chopra, Teena et. al.
Interactions between glycopeptides and beta-lactams against isogenic pairs of teicoplanin-susceptible and -resistant strains of Staphylococcus haemolyticus.
score: 1.1059703, Antimicrobial agents and chemotherapy, 2006, Vignaroli, Carla; Biavasco, Francesca; Varaldo, Pietro E
6,7-dihydroxyflavone dramatically intensifies the susceptibility of methicillin-resistant or -sensitive Staphylococcus aureus to beta-lactams.
score: 1.1059555, Antimicrobial agents and chemotherapy, 2004, Sato, Youichi et. al.
Effects of subinhibitory concentrations of antibiotics on alpha-toxin (hla) gene expression of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates.
score: 1.1059452, Antimicrobial agents and chemotherapy, 1998, Ohlsen, K et. al.
Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model.
score: 1.1059339, Antimicrobial agents and chemotherapy, 2011, Hilliard, Jamese J et. al.
Molecular characterization of increasing fluoroquinolone resistance in Streptococcus pneumoniae isolates in Canada, 1997 to 2005.
score: 1.1059101, Antimicrobial agents and chemotherapy, 2007, Adam, Heather J et. al.
Efficacy of ceftobiprole Medocaril against Enterococcus faecalis in a murine urinary tract infection model.
score: 1.105906, Antimicrobial agents and chemotherapy, 2012, Singh, Kavindra V; Murray, Barbara E
Development of a human immunodeficiency virus vector-based, single-cycle assay for evaluation of anti-integrase compounds.
score: 1.1058204, Antimicrobial agents and chemotherapy, 2006, Bona, Roberta et. al.
DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.
score: 1.1057405, Antimicrobial agents and chemotherapy, 2005, Cui, Longzhu et. al.
Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins.
score: 1.1057131, Antimicrobial agents and chemotherapy, 2012, Dubée, Vincent et. al.
A fluoroquinolone-resistant Escherichia coli clinical isolate without quinolone resistance-determining region mutations found in Japan.
score: 1.1057076, Antimicrobial agents and chemotherapy, 2011, Sato, Toyotaka et. al.
Detection of OXA-48 carbapenemase in the pandemic clone Escherichia coli O25b:H4-ST131 in the course of investigation of an outbreak of OXA-48-producing Klebsiella pneumoniae.
score: 1.1057076, Antimicrobial agents and chemotherapy, 2012, Morris, Dearbháile et. al.
When carbapenem-hydrolyzing beta-lactamase Kpc meets Escherichia coli ST131 in France.
score: 1.1057076, Antimicrobial agents and chemotherapy, 2011, Naas, Thierry et. al.
The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates
score: 1.1057025, Bioorganic & Medicinal Chemistry, 1998, Martin, Richard; Witte, Krista L.; Wong, Chi-Huey
In vitro activities of sitafloxacin (DU-6859a) and six other fluoroquinolones against 8,796 clinical bacterial isolates.
score: 1.1056721, Antimicrobial agents and chemotherapy, 2000, Milatovic, D et. al.
Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity
score: 1.1056611, European Journal of Medicinal Chemistry, 2010, Trávníček, Zdeněk et. al.
Anti-allergic principles from Thai zedoary: structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-α and IL-4 in RBL-2H3 cells
score: 1.1056306, Bioorganic & Medicinal Chemistry, 2004, Matsuda, Hisashi et. al.
Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes.
score: 1.1056121, Antimicrobial agents and chemotherapy, 2006, García, Isabel et. al.
Overexpression of the multidrug efflux operon acrEF by insertional activation with IS1 or IS10 elements in Salmonella enterica serovar typhimurium DT204 acrB mutants selected with fluoroquinolones.
score: 1.1055933, Antimicrobial agents and chemotherapy, 2005, Olliver, Anne et. al.
Outer membrane permeability barrier in Escherichia coli mutants that are defective in the late acyltransferases of lipid A biosynthesis.
score: 1.1055875, Antimicrobial agents and chemotherapy, 1999, Vaara, M; Nurminen, M
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure–activity correlations with related alkaloids
score: 1.1055137, Bioorganic & Medicinal Chemistry, 2005, Kashiwada, Yoshiki et. al.
Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants.
score: 1.1054984, Antimicrobial agents and chemotherapy, 2012, Mohamed, Ami F et. al.
Antibody-Based fluorescence detection of kinase activity on a peptide array
score: 1.1054925, Bioorganic & Medicinal Chemistry Letters, 2002, Lesaicherre, Marie-Laure et. al.
Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits.
score: 1.1054091, Antimicrobial agents and chemotherapy, 2005, Petraitiene, Ruta et. al.
International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance.
score: 1.1053698, Antimicrobial agents and chemotherapy, 2011, Rudolf, Daniel et. al.
Symmetrical cationic triglycerides
score: 1.1053049, Bioorganic & Medicinal Chemistry, 2001, Obika, Satoshi et. al.
Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong.
score: 1.1052834, Antimicrobial agents and chemotherapy, 2003, Kam, Kai Man et. al.
Hybrid molecules between benzenesulfonamides and active antimicrobial benzo[ d]isothiazol-3-ones
score: 1.1052712, European Journal of Medicinal Chemistry, 2009, Zani, Franca et. al.
A new strategy for stereoselective synthesis of sialic acid-containing glycopeptide fragment
score: 1.105249, Bioorganic & Medicinal Chemistry, 1996, Wang, Zhi-Guang et. al.
Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study.
score: 1.1051977, Antimicrobial agents and chemotherapy, 2009, Tacconelli, Evelina et. al.
Quantitative impact of neutrophils on bacterial clearance in a murine pneumonia model.
score: 1.1051554, Antimicrobial agents and chemotherapy, 2011, Guo, Beining et. al.
Evaluation of low-dose, extended-interval clindamycin regimens against Staphylococcus aureus and Streptococcus pneumoniae using a dynamic in vitro model of infection.
score: 1.1051331, Antimicrobial agents and chemotherapy, 1999, Lewis, R E et. al.
Role of VltAB, an ABC transporter complex, in viologen tolerance in Streptococcus mutans.
score: 1.1051282, Antimicrobial agents and chemotherapy, 2011, Biswas, Saswati; Biswas, Indranil
Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds.
score: 1.1050299, Antimicrobial agents and chemotherapy, 2005, Buurman, Ed T et. al.
Assessment of the pharmacokinetic interaction between eltrombopag and lopinavir-ritonavir in healthy adult subjects.
score: 1.1049511, Antimicrobial agents and chemotherapy, 2012, Wire, Mary B et. al.
In vitro activity and interaction of clindamycin combined with dihydroartemisinin against Plasmodium falciparum.
score: 1.1049432, Antimicrobial agents and chemotherapy, 2003, Ramharter, M et. al.
Activities of triazole-echinocandin combinations against Candida species in biofilms and as planktonic cells.
score: 1.1049403, Antimicrobial agents and chemotherapy, 2011, Chatzimoschou, Athanasios et. al.
DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.
score: 1.1048714, Antimicrobial agents and chemotherapy, 1998, Pan, X S; Fisher, L M
N-Me- pAB-Glu-γ-Glu-γ-Tyr(3-NO 2): an internally quenched fluorogenic γ-glutamyl hydrolase substrate
score: 1.1048577, Bioorganic & Medicinal Chemistry Letters, 2001, Pankuch, Jessica J.; Coward, James K.
In vitro antimicrobial effects of various combinations of penicillin and clindamycin against four strains of Streptococcus pyogenes.
score: 1.1047781, Antimicrobial agents and chemotherapy, 1998, Stevens, D L; Madaras-Kelly, K J; Richards, D M
Inhibition of tumor suppressor protein p53-dependent transcription by a tetramerization domain peptide via hetero-oligomerization
score: 1.1047702, Bioorganic & Medicinal Chemistry Letters, 2012, Wada, Junya et. al.
Modulation of penicillin acylase properties via immobilization techniques: one-pot chemoenzymatic synthesis of cephamandole from cephalosporin C
score: 1.1047271, Bioorganic & Medicinal Chemistry Letters, 2001, Terreni, Marco et. al.
Lack of activity of orally administered clofazimine against intracellular Mycobacterium tuberculosis in whole-blood culture.
score: 1.1047161, Antimicrobial agents and chemotherapy, 2004, Janulionis, Ernestas et. al.
Determination of ddATP levels in human immunodeficiency virus-infected patients treated with dideoxyinosine.
score: 1.1046604, Antimicrobial agents and chemotherapy, 2004, Le Saint, Cecile et. al.
Hydrolysis of linear DNA duplex catalyzed by Co(III) complex of cyclen attached to polystyrene
score: 1.1046556, Bioorganic & Medicinal Chemistry Letters, 2001, Jeung, Chul-Seung et. al.
Pharmacokinetics and inflammatory-fluid penetration of moxifloxacin following oral or intravenous administration.
score: 1.1046417, Antimicrobial agents and chemotherapy, 1999, Wise, R; Andrews, J M; Marshall, G; Hartman, G
Mefloquine and new related compounds target the F(0) complex of the F(0)F(1) H(+)-ATPase of Streptococcus pneumoniae.
score: 1.1045082, Antimicrobial agents and chemotherapy, 2002, Martín-Galiano, Antonio Javier et. al.
A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia.
score: 1.1044647, Antimicrobial agents and chemotherapy, 1998, Marttila, H J et. al.
Synthesis, antimicrobial activity and molecular modeling of cobalt and nickel complexes containing the bulky ligand: bis[ N-(2,6-diisopropylphenyl)imino] acenaphthene
score: 1.1044571, European Journal of Medicinal Chemistry, 2005, El-Ayaan, Usama; Abdel-Aziz, Alaa A.-M.
Reactive oxygen species scavenging activity of aminoderivatized chitosan with different degree of deacetylation
score: 1.1044498, Bioorganic & Medicinal Chemistry, 2006, Je, Jae-Young; Kim, Se-Kwon
New syntheses and potential antimalarial activities of new ‘retinoid-like chalcones’
score: 1.1044212, European Journal of Medicinal Chemistry, 2006, Valla, Alain et. al.
Horizontal transfer of blaCMY-bearing plasmids among clinical Escherichia coli and Klebsiella pneumoniae isolates and emergence of cefepime-hydrolyzing CMY-19.
score: 1.1043969, Antimicrobial agents and chemotherapy, 2006, Wachino, Jun-ichi et. al.
Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.
score: 1.1043767, Antimicrobial agents and chemotherapy, 2012, Warren, Cirle A et. al.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
score: 1.1043352, Antimicrobial agents and chemotherapy, 2004, Literacka, Elzbieta et. al.
Inhibition of quorum sensing regulated biofilm formation in Serratia marcescens causing nosocomial infections
score: 1.1042289, Bioorganic & Medicinal Chemistry Letters, 2012, Bakkiyaraj, Dhamodharan et. al.
Inhibition of quorum sensing regulated biofilm formation in Serratia marcescens causing nosocomial infections
score: 1.1042289, Bioorganic & Medicinal Chemistry Letters, 2012, Bakkiyaraj, Dhamodharan et. al.
Inhibition of quorum sensing regulated biofilm formation in Serratia marcescens causing nosocomial infections
score: 1.1042289, Bioorganic & Medicinal Chemistry Letters, 2012, Bakkiyaraj, Dhamodharan et. al.
Clarification to the systematic review and meta-analysis involving tigecycline.
score: 1.1041837, Antimicrobial agents and chemotherapy, 2011, McGovern, Paul; Babinchak, Timothy; Quintana, Alvaro
Inducible AmpC beta-lactamase of a new member Enterobacteriaceae.
score: 1.1041569, Antimicrobial agents and chemotherapy, 2002, Bonnet, Richard et. al.
High-mannose-type glycan modifications of dihydrofolate reductase using glycan–methotrexate conjugates
score: 1.104075, Bioorganic & Medicinal Chemistry, 2006, Totani, Kiichiro et. al.
In vitro susceptibilities of 27 rickettsiae to 13 antimicrobials.
score: 1.1040664, Antimicrobial agents and chemotherapy, 1998, Rolain, J M; Maurin, M; Vestris, G; Raoult, D
Interspecies transfer of antibiotic resistance between Helicobacter pylori and Helicobacter acinonychis.
score: 1.1040169, Antimicrobial agents and chemotherapy, 2001, Pot, R G et. al.
Vancomycin and daptomycin pharmacodynamics differ against a site-directed Staphylococcus epidermidis mutant displaying the small-colony-variant phenotype.
score: 1.1039675, Antimicrobial agents and chemotherapy, 2009, Wu, Marina et. al.
Amide and ester derivatives of N 3-(4-methoxyfumaroyl)-( S)-2,3-diaminopropanoic acid
score: 1.1039475, Bioorganic & Medicinal Chemistry, 2001, Zgódka, Dorota et. al.
A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates
score: 1.1039392, Scientia Pharmaceutica, 2011, Kaminskyy, Danylo et. al.
In vitro activity of sanfetrinem and affinity for the penicillin-binding proteins of Streptococcus pneumoniae.
score: 1.1039363, Antimicrobial agents and chemotherapy, 1998, Sifaoui, F; Varon, E; Kitzis, M D; Gutmann, L
Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging
score: 1.1039084, European Journal of Medicinal Chemistry, 2009, Bourkoula, Athanasia et. al.
Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease.
score: 1.1038802, Antimicrobial agents and chemotherapy, 2008, Al-Nassir, Wafa N et. al.
In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations.
score: 1.1038724, Antimicrobial agents and chemotherapy, 2004, Shelburne, Samuel A et. al.
Lack of an effect of human immunodeficiency virus coinfection on the pharmacokinetics of entecavir in hepatitis B virus-infected patients.
score: 1.1038487, Antimicrobial agents and chemotherapy, 2008, Zhu, Min et. al.
Colistin is effective in treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa in cancer patients.
score: 1.1037852, Antimicrobial agents and chemotherapy, 2007, Hachem, Ray Y et. al.
Characterization and nucleotide sequence of a Klebsiella oxytoca cryptic plasmid encoding a CMY-type beta-lactamase: confirmation that the plasmid-mediated cephamycinase originated from the Citrobacter freundii AmpC beta-lactamase.
score: 1.1037453, Antimicrobial agents and chemotherapy, 1999, Wu, S W; Dornbusch, K; Kronvall, G; Norgren, M
Synthesis and anticancer activities of amphiphilic 5-fluoro-2′-deoxyuridylic acid prodrugs
score: 1.1037097, European Journal of Medicinal Chemistry, 2005, Ludwig, Peter S.; Schwendener, Reto A.; Schott, Herbert
Transformation of presumptive precursors to frontalin and exo-brevicomin by bark beetles and the west Indian sugarcane weevil (Coleoptera)
score: 1.1036306, Bioorganic & Medicinal Chemistry, 1996, Perez, Alice L. et. al.
Activities of three quinolones, alone and in combination with extended-spectrum cephalosporins or gentamicin, against Stenotrophomonas maltophilia.
score: 1.1036114, Antimicrobial agents and chemotherapy, 1998, Visalli, M A; Jacobs, M R; Appelbaum, P C
Application of a 5′-bridging phosphorothioate to probe divalent metal and hammerhead ribozyme mediated RNA cleavage
score: 1.1035211, Bioorganic & Medicinal Chemistry, 1997, Kuimelis, Robert G.; McLaughlin, Larry W.
Cellular solid-phase binding assay and mass spectrometry for screening of α4β7 integrin antagonists
score: 1.1035203, Bioorganic & Medicinal Chemistry Letters, 2001, Gottschling, Dirk et. al.
Safety, tolerability, and pharmacokinetics of intravenous oseltamivir: single- and multiple-dose phase I studies with healthy volunteers.
score: 1.1035064, Antimicrobial agents and chemotherapy, 2012, Brennan, Barbara J et. al.
Pseudomonas aeruginosa Syntrophy in Chronically Colonized Airways of Cystic Fibrosis Patients.
score: 1.1035004, Antimicrobial agents and chemotherapy, 2012, Qin, Xuan et. al.
(Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells
score: 1.1034686, European Journal of Medicinal Chemistry, 2010, Biersack, B.; Zoldakova, M.; Effenberger, K.; Schobert, R.
Fluorescence resonance energy transfer-based assay for characterization of hepatitis C virus NS3-4A protease activity in live cells.
score: 1.1033352, Antimicrobial agents and chemotherapy, 2009, Sabariegos, Rosario et. al.
Mechanisms and frequency of resistance to gatifloxacin in comparison to AM-1121 and ciprofloxacin in Staphylococcus aureus.
score: 1.1033345, Antimicrobial agents and chemotherapy, 2001, Ince, D; Hooper, D C
Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis
score: 1.1032978, Bioorganic & Medicinal Chemistry Letters, 2006, Komizu, Yuji; Matsumoto, Yoko; Ueoka, Ryuichi
Effect of amoxicillin use on oral microbiota in young children.
score: 1.1032277, Antimicrobial agents and chemotherapy, 2004, Ready, D et. al.
In Vitro Antifungal Activity of Isavuconazole against Madurella mycetomatis.
score: 1.1032112, Antimicrobial agents and chemotherapy, 2012, Kloezen, Wendy et. al.
mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis.
score: 1.1032095, Antimicrobial agents and chemotherapy, 2005, Pasca, Maria R et. al.
Association between resistance to erythromycin and the presence of the fibronectin binding protein F1 gene, prtF1, in Streptococcus pyogenes isolates from German pediatric patients.
score: 1.1031426, Antimicrobial agents and chemotherapy, 2005, Haller, Maria et. al.
Extended protection against phlebovirus infection conferred by recombinant adenovirus expressing consensus interferon (DEF201).
score: 1.1031425, Antimicrobial agents and chemotherapy, 2012, Gowen, Brian B et. al.
Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis.
score: 1.1029578, Antimicrobial agents and chemotherapy, 2006, Lionakis, Michail S et. al.
Synthesis and properties of some novel anti-calmodulin drugs
score: 1.1029237, Bioorganic & Medicinal Chemistry, 1999, Sakai, Ted T.; Krishna, N.Rama
Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori.
score: 1.102902, Antimicrobial agents and chemotherapy, 2000, Kwon, D H et. al.
Diversity of Tn1546 elements in clinical isolates of glycopeptide-resistant enterococci from Scottish hospitals.
score: 1.10283, Antimicrobial agents and chemotherapy, 2001, Brown, A R; Townsley, A C; Amyes, S G
Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent
score: 1.1028199, Bioorganic & Medicinal Chemistry Letters, 2008, Park, Ji-Ae et. al.
Identification and minisequencing-based discrimination of SHV beta-lactamases in nosocomial infection-associated Klebsiella pneumoniae in Brisbane, Australia.
score: 1.1026897, Antimicrobial agents and chemotherapy, 2002, Howard, Christopher et. al.
The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum.
score: 1.1026805, Antimicrobial agents and chemotherapy, 2011, Kaewpongsri, S et. al.
Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase
score: 1.1026428, Bioorganic & Medicinal Chemistry Letters, 2008, Kapur, Shiven et. al.
Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical
score: 1.1025937, Bioorganic & Medicinal Chemistry Letters, 2010, Dhimitruka, Ilirian et. al.
Mechanism of action of T-705 against influenza virus.
score: 1.1025849, Antimicrobial agents and chemotherapy, 2005, Furuta, Yousuke et. al.
Efficacy and safety of nemonoxacin versus levofloxacin for community-acquired pneumonia.
score: 1.1025803, Antimicrobial agents and chemotherapy, 2010, van Rensburg, Dirkie J J et. al.
Increasing genetic relatedness of ciprofloxacin-resistant Streptococcus pneumoniae isolated in Canada from 1997 to 2005.
score: 1.1025738, Antimicrobial agents and chemotherapy, 2008, Nichol, Kimberly A et. al.
Tissue penetration of telavancin after intravenous administration in healthy subjects.
score: 1.1025725, Antimicrobial agents and chemotherapy, 2006, Sun, Heather K et. al.
Effects of ritonavir on indinavir pharmacokinetics in cerebrospinal fluid and plasma.
score: 1.10252, Antimicrobial agents and chemotherapy, 2003, Haas, David W et. al.
Bis(acridine-9-carboxylate)-nitro-europium(III) dihydrate complex a new apoptotic agent through Flk-1 down regulation, caspase-3 activation and oligonucleosomes DNA fragmentation
score: 1.1025186, Bioorganic & Medicinal Chemistry, 2013, Azab, Hassan A. et. al.
Human pre-elafin inhibits a Pseudomonas aeruginosa-secreted peptidase and prevents its proliferation in complex media.
score: 1.1025019, Antimicrobial agents and chemotherapy, 2008, Bellemare, Audrey et. al.
Macrolide resistance determinants of invasive and noninvasive group B streptococci in a Turkish hospital.
score: 1.102431, Antimicrobial agents and chemotherapy, 2004, Acikgoz, Ziya Cibali et. al.
Lack of effect of recombinant human growth hormone on the in vitro activities of antiretroviral drugs against human immunodeficiency virus type 1.
score: 1.1023924, Antimicrobial agents and chemotherapy, 2004, Wainberg, Mark A et. al.
Antischistosomal activities of mefloquine-related arylmethanols.
score: 1.1023908, Antimicrobial agents and chemotherapy, 2012, Ingram, Katrin; Ellis, William; Keiser, Jennifer
Molecular characterization of Staphylococcus aureus isolates from a 2005 clinical trial of uncomplicated skin and skin structure infections.
score: 1.1023286, Antimicrobial agents and chemotherapy, 2007, Jones, Ronald N et. al.
Substituted pyrazoles as novel selective ligands for the human dopamine D 4 receptor
score: 1.1023094, Bioorganic & Medicinal Chemistry, 1998, Bourrain, Sylvie et. al.
Penetration of piperacillin and tazobactam into inflamed soft tissue of patients with diabetic foot infection.
score: 1.1022595, Antimicrobial agents and chemotherapy, 2005, Legat, F J et. al.
1-Methoxy-, 1-deoxy-11-hydroxy- and 11-Hydroxy-1-methoxy-Δ 8-tetrahydrocannabinols: new selective ligands for the CB 2 receptor
score: 1.1022325, Bioorganic & Medicinal Chemistry, 2002, Huffman, John W et. al.
Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin.
score: 1.1022111, Antimicrobial agents and chemotherapy, 2005, Olson, Jon A et. al.
Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration
score: 1.1022093, Bioorganic & Medicinal Chemistry, 2009, Lu, Liang et. al.
Slow-binding inhibition of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase
score: 1.1021694, Bioorganic & Medicinal Chemistry, 2004, Braga, Rémi; Hecquet, Laurence; Blonski, Casimir
Synthesis and structure–activity relationships of potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
score: 1.1021423, Bioorganic & Medicinal Chemistry, 2004, Fukushima, Hiroshi et. al.
Probability of target attainment for ceftobiprole as derived from a population pharmacokinetic analysis of 150 subjects.
score: 1.1019975, Antimicrobial agents and chemotherapy, 2007, Lodise, Thomas P et. al.
Inhibition of hyphal growth of azole-resistant strains of Candida albicans by triazole antifungal agents in the presence of lactoferrin-related compounds.
score: 1.101982, Antimicrobial agents and chemotherapy, 1998, Wakabayashi, H et. al.
Bactericidal activity of first-choice antibiotics against gamma interferon-induced persistent infection of human epithelial cells by Chlamydia trachomatis.
score: 1.1019782, Antimicrobial agents and chemotherapy, 2005, Reveneau, Nathalie et. al.
Inhibition of angiogenesis by THAM-derived cotelomers endowed with thalidomide moieties
score: 1.1019248, Bioorganic & Medicinal Chemistry Letters, 2004, Périno, Sandrine et. al.
Optimization of aminoglycoside therapy.
score: 1.1018472, Antimicrobial agents and chemotherapy, 2011, Drusano, G L; Louie, Arnold
Iridoid glucosides from Nyctanthes arbortristis result in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite
score: 1.1018372, European Journal of Medicinal Chemistry, 2012, Shukla, Anil Kumar; Patra, Sanjukta; Dubey, Vikash Kumar
Iridoid glucosides from Nyctanthes arbortristis result in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite
score: 1.1018372, European Journal of Medicinal Chemistry, 2012, Shukla, Anil Kumar; Patra, Sanjukta; Dubey, Vikash Kumar
Identification of novel mammalian squalene synthase inhibitors using a three-Dimensional pharmacophore
score: 1.1018116, Bioorganic & Medicinal Chemistry, 2002, Fairlamb, Ian J.S. et. al.
Antibiotic resistance in Haemophilus influenzae decreased, except for beta-lactamase-negative amoxicillin-resistant isolates, in parallel with community antibiotic consumption in Spain from 1997 to 2007.
score: 1.1017475, Antimicrobial agents and chemotherapy, 2008, García-Cobos, Silvia et. al.
Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, low-level methicillin-resistant Staphylococcus haemolyticus.
score: 1.1017045, Antimicrobial agents and chemotherapy, 2001, Katayama, Y; Ito, T; Hiramatsu, K
Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin.
score: 1.101592, Antimicrobial agents and chemotherapy, 2008, Caridha, D et. al.
Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidime.
score: 1.1015171, Antimicrobial agents and chemotherapy, 1998, Therrien, C; Sanschagrin, F; Palzkill, T; Levesque, R C
Pharmacokinetics of tobramycin in adults with cystic fibrosis: implications for once-daily administration.
score: 1.101495, Antimicrobial agents and chemotherapy, 2000, Beringer, P M; Vinks, A A; Jelliffe, R W; Shapiro, B J
Efficacy of new 5-nitroimidazoles against metronidazole-susceptible and -resistant Giardia, Trichomonas, and Entamoeba spp.
score: 1.1014516, Antimicrobial agents and chemotherapy, 1999, Upcroft, J A et. al.
Libertellenones A–D: Induction of cytotoxic diterpenoid biosynthesis by marine microbial competition
score: 1.1014464, Bioorganic & Medicinal Chemistry, 2005, Oh, Dong-Chan et. al.
Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase
score: 1.1014338, Bioorganic & Medicinal Chemistry Letters, 2012, Xia, Ye; Liu, Ji-Hua; Liu, Jing-Han; Yu, Bo-Yang
Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase
score: 1.1014338, Bioorganic & Medicinal Chemistry Letters, 2012, Xia, Ye; Liu, Ji-Hua; Liu, Jing-Han; Yu, Bo-Yang
Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase
score: 1.1014338, Bioorganic & Medicinal Chemistry Letters, 2012, Xia, Ye; Liu, Ji-Hua; Liu, Jing-Han; Yu, Bo-Yang
Activities of trovafloxacin and ampicillin-sulbactam alone or in combination versus three strains of vancomycin- intermediate Staphylococcus aureus in an in vitro pharmacodynamic infection model.
score: 1.1014274, Antimicrobial agents and chemotherapy, 2000, Aeschlimann, J R; Hershberger, E; Rybak, M J
Study on synthesis, structure, and DNA-binding of lanthanide complexes with 2-carboxylbenzaldehyde thiosemicarbazone
score: 1.1013028, Bioorganic & Medicinal Chemistry Letters, 2007, Yang, Zheng-Yin; Wang, Yuan; Wang, Yan
Comparison of the fungicidal activities of caspofungin and amphotericin B against Candida glabrata.
score: 1.1013012, Antimicrobial agents and chemotherapy, 2005, Barchiesi, Francesco et. al.
Secretion of E,E-farnesol and biofilm formation in eight different Candida species.
score: 1.1013003, Antimicrobial agents and chemotherapy, 2008, Weber, K; Sohr, R; Schulz, B; Fleischhacker, M; Ruhnke, M
Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus.
score: 1.1012672, Antimicrobial agents and chemotherapy, 2010, Zhu, Wenming et. al.
Combination treatment with intralesional cidofovir and viral-DNA vaccination cures large cottontail rabbit papillomavirus-induced papillomas and reduces recurrences.
score: 1.1012113, Antimicrobial agents and chemotherapy, 2001, Christensen, N D; Han, R; Cladel, N M; Pickel, M D
Antimicrobial susceptibility patterns of enterococci causing infections in Europe. The European VRE Study Group.
score: 1.1011958, Antimicrobial agents and chemotherapy, 1999, Schouten, M A; Voss, A; Hoogkamp-Korstanje, J A
Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, ganoderma lucidum
score: 1.1011192, Bioorganic & Medicinal Chemistry, 1999, Mizushina, Yoshiyuki et. al.
Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa.
score: 1.1010289, Antimicrobial agents and chemotherapy, 2000, Maseda, H; Yoneyama, H; Nakae, T
Towards the development of novel antibiotics: synthesis and evaluation of a mechanism-based inhibitor of Kdo8P synthase
score: 1.1008885, Bioorganic & Medicinal Chemistry, 1999, Du, Shoucheng; Faiger, Hana; Belakhov, Valery; Baasov, Timor
The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis.
score: 1.1008107, Antimicrobial agents and chemotherapy, 2004, Padalko, Elizaveta et. al.
Suitable disk antimicrobial susceptibility breakpoints defining Salmonella enterica serovar Typhi isolates with reduced susceptibility to fluoroquinolones.
score: 1.1008099, Antimicrobial agents and chemotherapy, 2010, Parry, Christopher M et. al.
Chloroquine resistance in Plasmodium vivax.
score: 1.100809, Antimicrobial agents and chemotherapy, 2004, Baird, J Kevin
Biological studies of new organotin(IV) complexes of thioamide ligands
score: 1.1007885, European Journal of Medicinal Chemistry, 2008, Xanthopoulou, Marianna N. et. al.
Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.
score: 1.1007799, Antimicrobial agents and chemotherapy, 2005, Wiederhold, Nathan P et. al.
Synthesis, structure–activity relationship, and p210 bcr-abl protein tyrosine kinase activity of novel AG 957 analogs
score: 1.1007756, Bioorganic & Medicinal Chemistry, 2005, Kaur, Gurmeet et. al.
Structural Requirements of Flavonoids for Nitric Oxide Production Inhibitory Activity and Mechanism of Action
score: 1.1007352, Bioorganic & Medicinal Chemistry, 2003, Matsuda, Hisashi et. al.
Successful use of voriconazole for treatment of Coccidioides meningitis.
score: 1.1007107, Antimicrobial agents and chemotherapy, 2004, Proia, Laurie A; Tenorio, Allan R
Bacteremia due to extended-spectrum-beta-lactamase-producing Enterobacter cloacae: role of carbapenem therapy.
score: 1.1006574, Antimicrobial agents and chemotherapy, 2010, Lee, Ching-Chi et. al.
Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach
score: 1.1006045, Bioorganic & Medicinal Chemistry, 1999, Takayama, Shuichi et. al.
Antibiotic modulation of the plasminogen binding ability of viridans group streptococci.
score: 1.1005627, Antimicrobial agents and chemotherapy, 2012, Teles, Cristina; Smith, Andrew; Lang, Sue
Mechanism by which mutations at his274 alter sensitivity of influenza a virus n1 neuraminidase to oseltamivir carboxylate and zanamivir.
score: 1.1005513, Antimicrobial agents and chemotherapy, 2002, Wang, Michael Z; Tai, Chun Y; Mendel, Dirk B
In vitro activity of rifaximin against enteropathogens producing traveler's diarrhea.
score: 1.1005031, Antimicrobial agents and chemotherapy, 2001, Sierra, J M; Ruiz, J; Navia, M M; Vargas, M; Vila, J
Antiproliferative effect of novel platinum(II) and palladium(II) complexes on hepatic tumor stem cells in vitro
score: 1.100374, European Journal of Medicinal Chemistry, 2012, Miklášová, Natalia et. al.
Phenotypic and genotypic characterization of Streptococcus pyogenes isolates displaying the MLSB phenotype of macrolide resistance in Spain, 1999 to 2005.
score: 1.1003629, Antimicrobial agents and chemotherapy, 2007, Pérez-Trallero, Emilio et. al.
QSAR of anticancer compounds. bis(11-oxo-11 H-indeno[1,2- b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides)
score: 1.1003427, Bioorganic & Medicinal Chemistry, 2001, Mekapati, Suresh Babu et. al.
Oxidation products of quercetin catalyzed by mushroom tyrosinase
score: 1.1002485, Bioorganic & Medicinal Chemistry, 2004, Kubo, Isao; Nihei, Ken-ichi; Shimizu, Kuniyoshi
Development of a robust cytopathic effect-based high-throughput screening assay to identify novel inhibitors of dengue virus.
score: 1.1002357, Antimicrobial agents and chemotherapy, 2012, McCormick, Kevin D et. al.
Synthesis and antiproliferative activity of 3-aryl-2-(1 H-benzotriazol-1-yl)acrylonitriles. Part III
score: 1.1001984, European Journal of Medicinal Chemistry, 2002, Carta, Antonio et. al.
Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants.
score: 1.1001922, Antimicrobial agents and chemotherapy, 1999, Okuda, J; Hayakawa, E; Nishibuchi, M; Nishino, T
Design, synthesis and antibacterial activity of minor groove binders: The role of non-cationic tail groups
score: 1.1001897, European Journal of Medicinal Chemistry, 2012, Khalaf, Abedawn I. et. al.
Method for measuring postantifungal effect in Aspergillus species.
score: 1.1001753, Antimicrobial agents and chemotherapy, 2002, Vitale, Roxana G et. al.
Synthesis and biological evaluation of phosphonated carbocyclic 2′-oxa-3′-aza-nucleosides
score: 1.1001718, Bioorganic & Medicinal Chemistry, 2006, Chiacchio, Ugo et. al.
Highly sequence selective nonmacrocyclic two-armed receptors for peptides
score: 1.1001465, Bioorganic & Medicinal Chemistry Letters, 1999, Iorio, Edward James; Still, W.Clark
Chiral cyclopalladated complexes derived from N, N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents
score: 1.1001125, Bioorganic & Medicinal Chemistry, 2005, Bincoletto, Cláudia et. al.
Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect.
score: 1.1001071, Antimicrobial agents and chemotherapy, 2005, Stubbings, William et. al.
Spectroscopic studies on the formation and thermal stability of DNA triplexes with a benzoannulated δ-carboline–oligonucleotide conjugate
score: 1.1000924, Bioorganic & Medicinal Chemistry, 2008, Eick, Andrea; Xiao, Zhou; Langer, Peter; Weisz, Klaus
Generation of predictive pharmacophore model for SARS-coronavirus main proteinase
score: 1.1000616, European Journal of Medicinal Chemistry, 2005, Zhang, Xue Wu; Yap, Yee Leng; Altmeyer, Ralf M.
Antiprion activity of cholesterol esterification modulators: a comparative study using ex vivo sheep fibroblasts and lymphocytes and mouse neuroblastoma cell lines.
score: 1.0999227, Antimicrobial agents and chemotherapy, 2007, Pani, Alessandra et. al.
Characterization of emodin metabolites in Raji cells by LC–APCI-MS/MS
score: 1.0999038, Bioorganic & Medicinal Chemistry, 2009, Koyama, Junko et. al.
Antimicrobial resistance of old and recent Staphylococcus aureus isolates from poultry: first detection of livestock-associated methicillin-resistant strain ST398.
score: 1.0998898, Antimicrobial agents and chemotherapy, 2008, Nemati, Mostafa et. al.
Fluorine-18 labeled galactosylated chitosan for asialoglycoprotein-receptor-mediated hepatocyte imaging
score: 1.0998702, Bioorganic & Medicinal Chemistry Letters, 2010, Yang, Wenjiang et. al.
Observation and elimination of N-acetylation of oligonucleotides prepared using fast-deprotecting phosphoramidites and ultra-mild deprotection
score: 1.0997842, Bioorganic & Medicinal Chemistry Letters, 2001, Zhu, Qiang; Delaney, Michael O; Greenberg, Marc M
Analysis of rifapentine for preventive therapy in the Cornell mouse model of latent tuberculosis.
score: 1.0997566, Antimicrobial agents and chemotherapy, 1999, Miyazaki, E; Chaisson, R E; Bishai, W R
Combinatorial peptide microarrays for the rapid determination of kinase specificity
score: 1.0997532, Bioorganic & Medicinal Chemistry Letters, 2003, Uttamchandani, Mahesh et. al.
Postantibiotic effect in Escherichia coli determined with real-time metabolic monitoring.
score: 1.0996959, Antimicrobial agents and chemotherapy, 1998, Libby, J M
Integration of a transposon Tn1-encoded inhibitor-resistant beta-lactamase gene, bla(TEM-67) from Proteus mirabilis, into the Escherichia coli chromosome.
score: 1.0996959, Antimicrobial agents and chemotherapy, 2003, Naas, Thierry et. al.
In vitro gene delivery by a novel human calcitonin (hCT)-derived carrier peptide
score: 1.0996847, Bioorganic & Medicinal Chemistry Letters, 2004, Krauss, Ulrike et. al.
Novel Glycolipid TLR2 Ligands of the Type Pam2Cys-α-Gal: Synthesis and Biological Properties
score: 1.09967, European Journal of Medicinal Chemistry, 2012, Thomann, Jean-Sébastien et. al.
Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones
score: 1.0996363, European Journal of Medicinal Chemistry, 2005, Ryu, Chung-Kyu et. al.
Antimicrobial susceptibilities of health care-associated and community-associated strains of methicillin-resistant Staphylococcus aureus from hospitalized patients in Canada, 1995 to 2008.
score: 1.0995963, Antimicrobial agents and chemotherapy, 2010, Simor, Andrew E et. al.
Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.
score: 1.0995898, Antimicrobial agents and chemotherapy, 2010, Painter, Heather J; Morrisey, Joanne M; Vaidya, Akhil B
Comparison of lipid amphotericin B preparations in treating murine zygomycosis.
score: 1.0995658, Antimicrobial agents and chemotherapy, 2008, Ibrahim, Ashraf S et. al.
Effects of a 3-Alkyl-, 4-Hydroxy- and/or 8-Aromatic-substituent on the Phenylethanolamine N-Methyltransferase Inhibitor Potency and α 2-Adrenoceptor Affinity of 2,3,4,5-Tetrahydro-1 H-2-benzazepines
score: 1.0994827, Bioorganic & Medicinal Chemistry, 2001, Grunewald, Gary L.; Dahanukar, Vilas H.; Criscione, Kevin R.
In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp.
score: 1.0994499, Antimicrobial agents and chemotherapy, 2012, Planche, Virginie et. al.
Susceptibilities of simian immunodeficiency virus to protease inhibitors.
score: 1.0993872, Antimicrobial agents and chemotherapy, 2003, Giuffre, Angelica C et. al.
Inhibition of type 2 isopentenyl diphosphate isomerase from Methanocaldococcus jannaschii by a mechanism-based inhibitor of type 1 isopentenyl diphosphate isomerase
score: 1.0993859, Bioorganic & Medicinal Chemistry, 2006, Hoshino, Takeshi et. al.
Pharmacokinetics-pharmacodynamics of rifampin in an aerosol infection model of tuberculosis.
score: 1.0993775, Antimicrobial agents and chemotherapy, 2003, Jayaram, Ramesh et. al.
Sensitivity of amoxicillin-resistant Helicobacter pylori to other penicillins.
score: 1.0993745, Antimicrobial agents and chemotherapy, 1999, Dore, M P et. al.
Thalassiolins A–C: new marine-derived inhibitors of HIV cDNA integrase
score: 1.0993339, Bioorganic & Medicinal Chemistry, 2002, Rowley, David C et. al.
Synthesis of [11C]Dehydropravastatin, a PET Probe Potentially Useful for Studying OATP1B1 and MRP2 Transporters in the Liver
score: 1.0993318, Bioorganic & Medicinal Chemistry, 2012, Ijuin, Ryosuke et. al.
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated in Nepal.
score: 1.0992907, Antimicrobial agents and chemotherapy, 2012, Poudel, Ajay et. al.
Tyrphostins IV—Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines
score: 1.0992837, Bioorganic & Medicinal Chemistry, 1996, Gazit, Aviv et. al.
Transferable multidrug resistance plasmid carrying cfr associated with tet(L), ant(4')-Ia, and dfrK genes from a clinical methicillin-resistant Staphylococcus aureus ST125 strain.
score: 1.0992797, Antimicrobial agents and chemotherapy, 2012, Gopegui, Enrique Ruiz de et. al.
Penetration of vancomycin into epithelial lining fluid in healthy volunteers.
score: 1.0991348, Antimicrobial agents and chemotherapy, 2011, Lodise, Thomas P et. al.
Structure–activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells
score: 1.0990894, Bioorganic & Medicinal Chemistry, 2003, Ojima, Iwao et. al.
Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF 3CO-DDACTHF
score: 1.0989903, Bioorganic & Medicinal Chemistry, 2005, Chong, Youhoon et. al.
Combination of quinupristin-dalfopristin and gentamicin against methicillin-resistant Staphylococcus aureus: experimental rabbit endocarditis study.
score: 1.0989577, Antimicrobial agents and chemotherapy, 2002, Batard, Eric et. al.
Towards a model for the inhibition of choline kinase by a new type of inhibitor
score: 1.098935, European Journal of Medicinal Chemistry, 2005, Conejo-García, Ana et. al.
CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni.
score: 1.0988126, Antimicrobial agents and chemotherapy, 2005, Lin, Jun; Akiba, Masato; Sahin, Orhan; Zhang, Qijing
Chromosome- and plasmid-encoded beta-lactamases in Capnocytophaga spp.
score: 1.0987713, Antimicrobial agents and chemotherapy, 2005, Handal, Trude et. al.
Detection of Tn917-like sequences within a Tn916-like conjugative transposon (Tn3872) in erythromycin-resistant isolates of Streptococcus pneumoniae.
score: 1.0987042, Antimicrobial agents and chemotherapy, 1998, McDougal, L K et. al.
1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells.
score: 1.0986775, Antimicrobial agents and chemotherapy, 2010, Rinaldo, Christine Hanssen et. al.
Activation of the Unfolded Protein Response by 2-Deoxy-D-Glucose Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication and Gene Expression.
score: 1.0986556, Antimicrobial agents and chemotherapy, 2012, Leung, Howard J et. al.
Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV.
score: 1.0986322, Antimicrobial agents and chemotherapy, 1999, Akasaka, T; Onodera, Y; Tanaka, M; Sato, K
Synthesis and evaluation of novel enhanced gene reporter molecules: Detection of β-galactosidase activity using 19F NMR of trifluoromethylated aryl β- d-galactopyranosides
score: 1.0986178, Bioorganic & Medicinal Chemistry, 2006, Yu, Jianxin et. al.
Comparative bactericidal activities of ciprofloxacin, clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Streptococcus pneumoniae in a dynamic in vitro model.
score: 1.0985371, Antimicrobial agents and chemotherapy, 2001, Klepser, M E et. al.
Fluorescein-based amino acids for solid phase synthesis of fluorogenic protease substrates
score: 1.0985043, Bioorganic & Medicinal Chemistry, 2006, Burchak, Olga N. et. al.
Integron-associated antibiotic resistance in Salmonella enterica serovar typhi from Asia.
score: 1.0985016, Antimicrobial agents and chemotherapy, 2003, Ploy, Marie-Cécile et. al.
ISEcp1-mediated transposition and homologous recombination can explain the context of bla(CTX-M-62) linked to qnrB2.
score: 1.0984935, Antimicrobial agents and chemotherapy, 2010, Zong, Zhiyong; Partridge, Sally R; Iredell, Jonathan R
Enterococcus faecium low-affinity pbp5 is a transferable determinant.
score: 1.0983786, Antimicrobial agents and chemotherapy, 2005, Rice, Louis B et. al.
Differential antifungal activity of isomeric forms of nystatin.
score: 1.0983638, Antimicrobial agents and chemotherapy, 2001, Ostrosky-Zeichner, L et. al.
Efficacy of LFF571 in a hamster model of Clostridium difficile infection.
score: 1.0983489, Antimicrobial agents and chemotherapy, 2012, Trzasko, Anna et. al.
Lack of effect of simultaneously administered didanosine encapsulated enteric bead formulation (Videx EC) on oral absorption of indinavir, ketoconazole, or ciprofloxacin.
score: 1.0982795, Antimicrobial agents and chemotherapy, 2002, Damle, Bharat D et. al.
Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.
score: 1.0982728, Antimicrobial agents and chemotherapy, 2004, Mariga, S T et. al.
Carriage of an ACME II variant may have contributed to methicillin-resistant Staphylococcus aureus sequence type 239-like strain replacement in Liverpool Hospital, Sydney, Australia.
score: 1.0982359, Antimicrobial agents and chemotherapy, 2012, Espedido, B A et. al.
Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification
score: 1.0981923, Bioorganic & Medicinal Chemistry, 2006, Komoriya, Satoshi et. al.
Discovery of novel non-peptidic ketopiperazine-based renin inhibitors
score: 1.0981703, Bioorganic & Medicinal Chemistry, 2005, Holsworth, Daniel D. et. al.
Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration.
score: 1.0981088, Antimicrobial agents and chemotherapy, 2012, Dolton, Michael J et. al.
Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure–activity and resistance relationships; different scaffolds and mutations
score: 1.0981006, Bioorganic & Medicinal Chemistry, 2012, Mayhoub, Abdelrahman S.
Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure–activity and resistance relationships; different scaffolds and mutations
score: 1.0981006, Bioorganic & Medicinal Chemistry, 2012, Mayhoub, Abdelrahman S.
Synthesis, Characterization and Antitumor Activity of Novel Octahedral Pt(IV) Complexes
score: 1.0980549, Bioorganic & Medicinal Chemistry, 2003, Kwon, Young-Ee; Whang, Kyu-Ja; Park, Young-Ja; Kim, Kuk Hwan
Photodynamic inactivation of Escherichia coli and Streptococcus mitis by cationic zinc(II) phthalocyanines in media with blood derivatives
score: 1.0979623, European Journal of Medicinal Chemistry, 2010, Spesia, Mariana B.; Rovera, Marisa; Durantini, Edgardo N.
In vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the Transplant-Associated Infection Surveillance Network.
score: 1.0979217, Antimicrobial agents and chemotherapy, 2011, Lockhart, Shawn R et. al.
Synthesis and hybridization properties of the conjugates of oligonucleotides and stabilization agents—II
score: 1.0979055, Bioorganic & Medicinal Chemistry, 1997, Balbi, A. et. al.
Multicenter study of voriconazole pharmacokinetics and therapeutic drug monitoring.
score: 1.0977591, Antimicrobial agents and chemotherapy, 2012, Dolton, Michael J et. al.
Quantification of different human alpha interferon subtypes and pegylated interferon activities by measuring MxA promoter activation.
score: 1.0977299, Antimicrobial agents and chemotherapy, 2005, François, Catherine et. al.
In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum.
score: 1.0977152, Antimicrobial agents and chemotherapy, 2000, Akompong, T; Ghori, N; Haldar, K
Classification of dopamine antagonists using functional feature hypothesis and topological descriptors
score: 1.0976936, Bioorganic & Medicinal Chemistry, 2006, Kim, Hye-Jung et. al.
Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum
score: 1.0976292, Bioorganic & Medicinal Chemistry Letters, 2003, Aiello, Anna et. al.
Burkholderia is highly resistant to human Beta-defensin 3.
score: 1.0976213, Antimicrobial agents and chemotherapy, 2003, Sahly, Hany et. al.
In vitro activities of garenoxacin (BMS-284756) against Streptococcus pneumoniae, viridans group streptococci, and Enterococcus faecalis compared to those of six other quinolones.
score: 1.0974836, Antimicrobial agents and chemotherapy, 2003, Grohs, Patrick et. al.
In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria.
score: 1.0973989, Antimicrobial agents and chemotherapy, 2000, van Ogtrop, M L et. al.
Rebeccamycin analogues from Indolo[2,3- c]carbazole
score: 1.0973713, Bioorganic & Medicinal Chemistry, 2001, Voldoire, Aline et. al.
Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae.
score: 1.0973474, Antimicrobial agents and chemotherapy, 1998, Trees, D L; Sandul, A L; Whittington, W L; Knapp, J S
Effect of ribonucleotide substitution on nucleic acid bulge recognition by neocarzinostatin
score: 1.0972226, Bioorganic & Medicinal Chemistry, 1997, Kappen, Lizzy S.; Xi, Zhen; Goldberg, Irving H.
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of ( R)- and ( S)- N-hydroxy-2-( N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides
score: 1.0972041, Bioorganic & Medicinal Chemistry, 2006, Tuccinardi, Tiziano et. al.
Rapid and reliable detection of antimicrobial peptide penetration into gram-negative bacteria based on fluorescence quenching.
score: 1.097179, Antimicrobial agents and chemotherapy, 2009, Benincasa, Monica et. al.
Synthesis and QSAR studies on 5-[2-(2-methylprop1-enyl)-1 H benzimidazol-1yl]-4,6-diphenyl-pyrimidin-2-(5 H)-thione derivatives as antibacterial agents
score: 1.0971788, European Journal of Medicinal Chemistry, 2006, Sharma, P.; Kumar, A.; Sharma, M.
Novel photoresponsive cross-linking oligodeoxyribonucleotides having a caged α-chloroaldehyde
score: 1.0971727, Bioorganic & Medicinal Chemistry, 2012, Kobori, Akio et. al.
blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513.
score: 1.0971403, Antimicrobial agents and chemotherapy, 2002, Arduino, Sonia M et. al.
De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library
score: 1.0971039, Bioorganic & Medicinal Chemistry Letters, 2004, Houghten, Richard A; Dooley, Colette T; Appel, Jon R
In vitro antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates obtained in Canada in 2002.
score: 1.0970013, Antimicrobial agents and chemotherapy, 2004, Powis, Jeff et. al.
Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides
score: 1.0969931, Bioorganic & Medicinal Chemistry, 2005, van Roon, Anne-Marie M. et. al.
Prevalence of fluoroquinolone resistance among tuberculosis patients in Shanghai, China.
score: 1.0969676, Antimicrobial agents and chemotherapy, 2009, Xu, Peng et. al.
In vitro interactions between new antitubercular drug candidates SQ109 and TMC207.
score: 1.0969483, Antimicrobial agents and chemotherapy, 2010, Reddy, Venkata M; Einck, Leo; Andries, K; Nacy, Carol A
Efficacy of FK463, a (1,3)-beta-D-glucan synthase inhibitor, in disseminated azole-resistant candida albicans infection in mice.
score: 1.0969057, Antimicrobial agents and chemotherapy, 2000, Maesaki, S et. al.
Imidazo–benzothiazoles a potent microRNA modulator involved in cell proliferation
score: 1.0968731, Bioorganic & Medicinal Chemistry Letters, 2012, Pushpavalli, Sreerangam N.C.V.L. et. al.
Risk Factors for Infection or Colonization with CTX-M Extended-Spectrum-β-Lactamase-Positive Escherichia coli.
score: 1.0968575, Antimicrobial agents and chemotherapy, 2012, Han, Jennifer H et. al.
Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery
score: 1.0967224, European Journal of Medicinal Chemistry, 2012, Chen, Haigang et. al.
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea
score: 1.0967003, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Cui et. al.
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea
score: 1.0967003, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Cui et. al.
Community-onset disease caused by Citrobacter freundii producing a novel CTX-M beta-lactamase, CTX-M-30, in Canada.
score: 1.0966851, Antimicrobial agents and chemotherapy, 2004, Abdalhamid, Baha et. al.
A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors
score: 1.0966623, Bioorganic & Medicinal Chemistry Letters, 2012, Schünemann, Katrin et. al.
Serotype 19f multiresistant pneumococcal clone harboring two erythromycin resistance determinants (erm(B) and mef(A)) in South Africa.
score: 1.0965968, Antimicrobial agents and chemotherapy, 2001, McGee, L; Klugman, K P; Wasas, A; Capper, T; Brink, A
Gemifloxacin is effective in experimental pneumococcal meningitis.
score: 1.0965413, Antimicrobial agents and chemotherapy, 2000, Smirnov, A et. al.
Toward the identification of selective modulators of protein kinase C (PKC) isozymes
score: 1.0965412, Bioorganic & Medicinal Chemistry, 2001, Shindo, Mayumi et. al.
Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses.
score: 1.0964917, Antimicrobial agents and chemotherapy, 2008, Shue, Y K et. al.
Synthesis, biological, and chiroptical activity of 3-phenyl-clavams
score: 1.0964905, Bioorganic & Medicinal Chemistry, 2004, Cierpucha, Maciej et. al.
An estradiol-Porphyrin conjugate selectively localizes into estrogen receptor-Positive breast cancer cells
score: 1.0964684, Bioorganic & Medicinal Chemistry, 2002, Swamy, Narasimha et. al.
Synthesis and biological activity of 4-alkoxy chalcones: potential hydrophobic modulators of p-glycoprotein-mediated multidrug resistance
score: 1.096263, Bioorganic & Medicinal Chemistry, 1999, Bois, Frédéric et. al.
New automated method for determining postantifungal effect of amphotericin B against Candida species: effects of concentration, exposure time, and area under the curve.
score: 1.0962364, Antimicrobial agents and chemotherapy, 2002, Chryssanthou, Erja; Cars, Otto; Sjölin, Jan
Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs.
score: 1.0961853, Antimicrobial agents and chemotherapy, 1999, Neyts, J; De Clercq, E
Bactericidal action of ofloxacin, sulbactam-ampicillin, rifampin, and isoniazid on logarithmic- and stationary-phase cultures of Mycobacterium tuberculosis.
score: 1.0961234, Antimicrobial agents and chemotherapy, 1996, Herbert, D et. al.
Target profiling of small molecules by chemical proteomics.
score: 1.0961098, Nature chemical biology, 2009, Rix, Uwe; Superti-Furga, Giulio
Incorporation of positively charged deoxynucleic S-Methylthiourea linkages into oligodeoxyribonucleotides
score: 1.0960969, Bioorganic & Medicinal Chemistry Letters, 2001, Challa, Hemavathi; Bruice, Thomas C
Lack of Evidence for Reduced Fitness of Clinical Staphylococcus aureus Isolates with Reduced Susceptibility to Triclosan.
score: 1.0960843, Antimicrobial agents and chemotherapy, 2012, Oggioni, Marco Rinaldo et. al.
Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.
score: 1.0960745, Antimicrobial agents and chemotherapy, 2003, Yigit, Hesna et. al.
Domino access to highly substituted chromans and isochromans from carbohydrates.
score: 1.0960457, Nature chemical biology, 2010, Leibeling, Markus et. al.
In vitro susceptibility of Clostridium difficile clinical isolates from a multi-institutional outbreak in Southern Québec, Canada.
score: 1.0960278, Antimicrobial agents and chemotherapy, 2006, Bourgault, Anne-Marie et. al.
QSAR studies in substituted 1,2,3,4,6,7,12,12a-octa-hydropyrazino[2′,1′:6,1]pyrido[3,4-b]indoles—a potent class of neuroleptics
score: 1.0958228, Bioorganic & Medicinal Chemistry, 2003, Saxena, Anil K. et. al.
The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold
score: 1.0958158, Bioorganic & Medicinal Chemistry, 1996, Smith, Amos B et. al.
Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz.
score: 1.0957901, Antimicrobial agents and chemotherapy, 2011, Cho, Doo-Yeoun et. al.
Candida albicans Infections in Renal Transplant Recipients: Effect of Caspofungin on Polymorphonuclear Cells.
score: 1.0957201, Antimicrobial agents and chemotherapy, 2011, Allizond, Valeria et. al.
Comparative pharmacokinetics of azithromycin in serum and white blood cells of healthy subjects receiving a single-dose extended-release regimen versus a 3-day immediate-release regimen.
score: 1.0957062, Antimicrobial agents and chemotherapy, 2007, Liu, Ping et. al.
Activities of the combination of quinupristin-dalfopristin with rifampin in vitro and in experimental endocarditis due to Staphylococcus aureus strains with various phenotypes of resistance to macrolide-lincosamide-streptogramin antibiotics.
score: 1.095679, Antimicrobial agents and chemotherapy, 2001, Zarrouk, V et. al.
Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells
score: 1.0955799, Bioorganic & Medicinal Chemistry, 2006, Søhoel, Helmer et. al.
First occurrence of a Pseudomonas aeruginosa isolate in the United States producing an IMP metallo-beta-lactamase, IMP-18.
score: 1.0955793, Antimicrobial agents and chemotherapy, 2006, Hanson, Nancy D et. al.
AbaR4-type resistance island including the blaOXA-23 gene in Acinetobacter nosocomialis isolates.
score: 1.0955793, Antimicrobial agents and chemotherapy, 2012, Kim, Dae Hun et. al.
Rapid and efficient oxidative decarboxylation of carboxylic acids with sodium periodate catalyzed by manganese (III) Schiff base complexes
score: 1.0955746, Bioorganic & Medicinal Chemistry, 2004, Mirkhani, Valiollah et. al.
Interaction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranes.
score: 1.0954702, Antimicrobial agents and chemotherapy, 2006, Bucki, Robert; Janmey, Paul A
A colorimetric assay for screening transketolase activity
score: 1.0954378, Bioorganic & Medicinal Chemistry, 2006, Smith, Mark E.B. et. al.
Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.
score: 1.0954036, Antimicrobial agents and chemotherapy, 1999, McMurry, L M; McDermott, P F; Levy, S B
1,12-Substituted tetracyclines as antioxidant agents
score: 1.0953862, Bioorganic & Medicinal Chemistry, 2005, Lertvorachon, Jittiwud et. al.
Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum.
score: 1.0953637, Antimicrobial agents and chemotherapy, 2011, Hage, Chadi A et. al.
Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for biomedical EPR applications
score: 1.0953608, Bioorganic & Medicinal Chemistry Letters, 2008, Driesschaert, Benoît et. al.
Lack of vancomycin tolerance in Streptococcus pneumoniae strains isolated in Barcelona, Spain, from 1999 to 2001.
score: 1.0953591, Antimicrobial agents and chemotherapy, 2003, Ortega, Mar et. al.
Contribution of rpoB2 RNA polymerase beta subunit gene to rifampin resistance in Nocardia species.
score: 1.0953528, Antimicrobial agents and chemotherapy, 2006, Ishikawa, Jun et. al.
Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong.
score: 1.095343, Antimicrobial agents and chemotherapy, 1999, Ho, P L; Que, T L; Tsang, D N; Ng, T K; Chow, K H; Seto, W H
In vitro activity of A-192411.29, a novel antifungal lipopeptide.
score: 1.0952911, Antimicrobial agents and chemotherapy, 2000, Nilius, A M et. al.
Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells
score: 1.0952221, Bioorganic & Medicinal Chemistry Letters, 2012, Jespersen, Christine et. al.
Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes.
score: 1.095163, Antimicrobial agents and chemotherapy, 2000, García, I; Pascual, A; Ballesta, S; Joyanes, P; Perea, E J
Correlation weighting of valence shells in QSAR analysis of toxicity
score: 1.0951435, Bioorganic & Medicinal Chemistry, 2006, Toropov, Andrey A.; Benfenati, Emilio
Pharmacokinetics of adjusted-dose lopinavir-ritonavir combined with rifampin in healthy volunteers.
score: 1.0950922, Antimicrobial agents and chemotherapy, 2004, la Porte, C J L et. al.
In Vivo Selection of Rifamycin-Resistant Clostridium difficile during Rifaximin Therapy.
score: 1.0950146, Antimicrobial agents and chemotherapy, 2012, Carman, Robert J et. al.
Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents
score: 1.0949461, European Journal of Medicinal Chemistry, 2012, Abdel-Wahab, Bakr F. et. al.
2′,5′-Oligoadenylate-peptide nucleic acids (2–5A-PNAs) activate RNase L
score: 1.0949263, Bioorganic & Medicinal Chemistry, 1999, Verheijen, Jeroen C et. al.
New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity
score: 1.0948433, Bioorganic & Medicinal Chemistry, 2005, Barbosa, Ticiano P. et. al.
N-Thiolated β-lactam antibacterials: Effects of the N-organothio substituent on anti-MRSA activity
score: 1.0947769, Bioorganic & Medicinal Chemistry, 2006, Heldreth, Bart et. al.
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.
score: 1.0947626, Antimicrobial agents and chemotherapy, 2000, Nagai, K et. al.
In vitro and in vivo antibacterial activities of TAK-083, an agent for treatment of Helicobacter pylori infection.
score: 1.0947385, Antimicrobial agents and chemotherapy, 2001, Kanamaru, T et. al.
Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.
score: 1.094702, Antimicrobial agents and chemotherapy, 2011, Krishna, Gopal et. al.
Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide
score: 1.0946861, Bioorganic & Medicinal Chemistry, 2003, Takahashi, Ryoko; Bando, Toshikazu; Sugiyama, Hiroshi
Novel synthetic isoquinolino[5,4- ab]phenazines: Inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities
score: 1.0946775, Bioorganic & Medicinal Chemistry, 2005, Yang, Peng; Yang, Qing; Qian, Xuhong; Cui, Jingnan
A quantitative structure–activity relationship study of hydroxamate matrix metalloproteinase inhibitors derived from funtionalized 4-aminoprolines
score: 1.0945746, Bioorganic & Medicinal Chemistry, 2003, Gupta, S.P.; Kumar, Dalip; Kumaran, S.
RNA specific molecules: Cytotoxic plant alkaloid palmatine binds strongly to poly(A)
score: 1.0945702, Bioorganic & Medicinal Chemistry Letters, 2006, Giri, Prabal; Hossain, Maidul; Kumar, Gopinatha Suresh
Novel combination of mutations in the DNA gyrase and topoisomerase IV genes in laboratory-grown fluoroquinolone-resistant Shigella flexneri mutants.
score: 1.0945076, Antimicrobial agents and chemotherapy, 1998, Chu, Y W; Houang, E T; Cheng, A F
Antimicrobial susceptibilities of clinical Desulfovibrio isolates.
score: 1.0943628, Antimicrobial agents and chemotherapy, 2001, Lozniewski, A; Labia, R; Haristoy, X; Mory, F
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea
score: 1.0943423, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Cui et. al.
Chemoenzymatic synthesis of CMP–sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP–sialic acid synthetases
score: 1.0943285, Bioorganic & Medicinal Chemistry, 2004, Yu, Hai; Yu, Hui; Karpel, Rebekah; Chen, Xi
KPC-2-producing sequence type 11 Klebsiella pneumoniae detected in Taiwan.
score: 1.0943192, Antimicrobial agents and chemotherapy, 2012, Lauderdale, Tsai-Ling et. al.
A novel galacto-glycerolipid from Oxalis corniculata kills Entamoeba histolytica and Giardia lamblia.
score: 1.0942457, Antimicrobial agents and chemotherapy, 2010, Manna, Dipak et. al.
New dibenzotropolone derivatives characterized from black tea using LC/MS/MS
score: 1.0941213, Bioorganic & Medicinal Chemistry, 2004, Sang, Shengmin et. al.
α-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases
score: 1.0941143, European Journal of Medicinal Chemistry, 2005, Drąg, Marcin et. al.
Worldwide antimicrobial susceptibility patterns and pharmacodynamic comparisons of gatifloxacin and levofloxacin against Streptococcus pneumoniae: report from the Antimicrobial Resistance Rate Epidemiology Study Team.
score: 1.0940615, Antimicrobial agents and chemotherapy, 2003, Jones, Ronald N et. al.
Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy.
score: 1.0940596, Antimicrobial agents and chemotherapy, 2000, Bacheler, L T et. al.
A rapid phenotypic assay for detection of acyclovir-resistant varicella-zoster virus with mutations in the thymidine kinase open reading frame.
score: 1.0940383, Antimicrobial agents and chemotherapy, 2000, Sahli, R; Andrei, G; Estrade, C; Snoeck, R; Meylan, P R
Postantibiotic effects of ABT-773 and amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae.
score: 1.0940213, Antimicrobial agents and chemotherapy, 2001, Neuhauser, M M; Prause, J L; Danziger, L H; Pendland, S L
Chemopreventive potential of cyclic diarylheptanoids
score: 1.0939485, Bioorganic & Medicinal Chemistry, 2002, Ishida, Junko et. al.
Azole cross-resistance in Aspergillus fumigatus.
score: 1.0939289, Antimicrobial agents and chemotherapy, 2002, Mosquera, J; Denning, D W
Structure-based phylogeny of the metallo-beta-lactamases.
score: 1.0939194, Antimicrobial agents and chemotherapy, 2005, Garau, Gianpiero; Di Guilmi, Anne Marie; Hall, Barry G
Downregulation of mdr1 and abcg2 genes is a mechanism of inhibition of efflux pumps mediated by polymeric amphiphiles
score: 1.0939045, Bioorganic & Medicinal Chemistry Letters, 2012, Cuestas, María L. et. al.
Downregulation of mdr1 and abcg2 genes is a mechanism of inhibition of efflux pumps mediated by polymeric amphiphiles
score: 1.0939045, Bioorganic & Medicinal Chemistry Letters, 2012, Cuestas, María L. et. al.
Evaluation of once-daily vancomycin against methicillin-resistant Staphylococcus aureus in a hollow-fiber infection model.
score: 1.0938896, Antimicrobial agents and chemotherapy, 2012, Nicasio, Anthony M et. al.
A plasmid-encoded class 1 integron contains GES-type extended-spectrum β-lactamases in Enterobacteriaceae clinical isolates in Mexico.
score: 1.0938506, Antimicrobial agents and chemotherapy, 2012, Barrios, Humberto et. al.
SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamases.
score: 1.0937902, Antimicrobial agents and chemotherapy, 2006, Queenan, Anne Marie et. al.
Emergence of fluoroquinolone-resistant strains of Vibrio cholerae O1 biotype El Tor among hospitalized patients with cholera in Calcutta, India.
score: 1.0937322, Antimicrobial agents and chemotherapy, 2001, Garg, P et. al.
SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae.
score: 1.0936514, Antimicrobial agents and chemotherapy, 2011, He, Gui-Xin et. al.
Dissemination of an NDM-2-producing Acinetobacter baumannii clone in an Israeli rehabilitation center.
score: 1.0936335, Antimicrobial agents and chemotherapy, 2011, Espinal, P et. al.
Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis
score: 1.0935554, Bioorganic & Medicinal Chemistry Letters, 2012, Kitajima, Hideki; Komizu, Yuji; Ueoka, Ryuichi
Synthesis and hybridization property of sugar and phosphate linkage modified oligonucleotides
score: 1.0935413, Bioorganic & Medicinal Chemistry, 1999, Jeong, Lak Shin et. al.
Preparation of 4,7-diphenyl-1,10-phenanthroline-2,9-dicarboxylic acid catalyzed by iron(III)porphyrins with (diacetoxyiodo)benzene
score: 1.0935279, Bioorganic & Medicinal Chemistry Letters, 2010, Zhong, Qi-Di et. al.
Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.
score: 1.0934916, Antimicrobial agents and chemotherapy, 2005, Conrads, Georg; Citron, Diane M; Goldstein, Ellie J C
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-Formyl-DDACTHF)
score: 1.0934804, Bioorganic & Medicinal Chemistry, 2002, Marsilje, Thomas H. et. al.
Pfmdr1 alleles and response to ultralow-dose mefloquine treatment in Gabonese patients.
score: 1.0934648, Antimicrobial agents and chemotherapy, 2002, Mawili-Mboumba, Denise P et. al.
Resistance to methotrexate due to AcrAB-dependent export from Escherichia coli.
score: 1.0934543, Antimicrobial agents and chemotherapy, 2000, Kopytek, S J; Dyer, J C; Knapp, G S; Hu, J C
Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.
score: 1.0934323, Antimicrobial agents and chemotherapy, 2000, Placidi, L et. al.
Characterization of Salmonella enterica serovar Typhimurium isolates harboring a chromosomally encoded CMY-2 beta-lactamase gene located on a multidrug resistance genomic island.
score: 1.0933921, Antimicrobial agents and chemotherapy, 2011, Shahada, Francis et. al.
A theoretical study of phenolic compounds with antioxidant properties
score: 1.0933905, European Journal of Medicinal Chemistry, 2007, Reis, Mauro et. al.
The T788G mutation in the cyp51C gene confers voriconazole resistance in Aspergillus flavus causing aspergillosis.
score: 1.0933869, Antimicrobial agents and chemotherapy, 2012, Liu, Wei et. al.
Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide
score: 1.0933748, Bioorganic & Medicinal Chemistry, 2000, He, Shu et. al.
Phage display of functional, full-length human and viral membrane proteins
score: 1.0933683, Bioorganic & Medicinal Chemistry Letters, 2008, Majumdar, Sudipta et. al.
Prediction of HIV-1 protease inhibitor resistance by Molecular Modeling Protocols (MMPs) using GenMol™ software
score: 1.0933672, European Journal of Medicinal Chemistry, 2008, Pèpe, G. et. al.
Synthesis, characterization, toxicity, cytogenetic and in vivo antitumor studies of 1,1-dithiolate Cu(II) complexes with di-, tri-, tetra- amines and 1,3-thiazoles. Structure–activity correlation
score: 1.0933421, Bioorganic & Medicinal Chemistry, 2009, Bolos, C.A. et. al.
In vitro assessment of the further potential for development of fluoroquinolone resistance in Neisseria meningitidis.
score: 1.0933138, Antimicrobial agents and chemotherapy, 2005, Shultz, Tiffany R; White, Peter A; Tapsall, John W
Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells
score: 1.0932679, Bioorganic & Medicinal Chemistry, 2005, Kolodziej, Herbert et. al.
Formation of a phospholipid-linked pyrrolecarbaldehyde from model reactions of d-glucose and 3-deoxyglucosone with phosphatidyl ethanolamine
score: 1.0932462, Bioorganic & Medicinal Chemistry, 2000, Lederer, Markus O.; Baumann, Markus
Screening and characterization of an inhibitory chemical specific to Arabidopsis gibberellin 2-oxidases
score: 1.0931356, Bioorganic & Medicinal Chemistry Letters, 2010, Otani, Masato et. al.
Interaction of common azole antifungals with P glycoprotein.
score: 1.0931348, Antimicrobial agents and chemotherapy, 2002, Wang, Er-jia et. al.
Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections.
score: 1.0931313, Antimicrobial agents and chemotherapy, 2000, Gisby, J; Bryant, J
5-(4′-Substituted-2′-nitroanilino)-1,2,3-triazoles as new potential potassium channel activators. I
score: 1.0930991, European Journal of Medicinal Chemistry, 2000, Biagi, Giuliana et. al.
Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-methyl-1,2,3,6-tetrahydropyridines
score: 1.093056, Bioorganic & Medicinal Chemistry, 1997, Franot, Christelle; Mabic, Stéphane; Castagnoli, Neal
Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-methyl-1,2,3,6-tetrahydropyridines
score: 1.093056, Bioorganic & Medicinal Chemistry, 1997, Franot, Christelle; Mabic, Stéphane; Castagnoli, Neal
In vitro activities of fluoroquinolones against the spirochete Borrelia burgdorferi.
score: 1.0930511, Antimicrobial agents and chemotherapy, 2001, Kraiczy, P et. al.
Effects of synthetic siderophores on proliferation of Plasmodium falciparum in infected human erythrocytes.
score: 1.0929977, Antimicrobial agents and chemotherapy, 2002, Rotheneder, Andrea et. al.
Differences in sensitivity to PA-1806 among iron transport mutants of Pseudomonas aeruginosa compared to Escherichia coli.
score: 1.0929728, Antimicrobial agents and chemotherapy, 2000, Schwan, W R; Barker, L; Brody, L L
Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay
score: 1.0929618, Bioorganic & Medicinal Chemistry Letters, 2003, Yeung, Bryan K.S.; Tse, Winston C.; Boger, Dale L.
Molecular analysis of the sequences surrounding blaOXA-45 reveals acquisition of this gene by Pseudomonas aeruginosa via a novel ISCR element, ISCR5.
score: 1.0929356, Antimicrobial agents and chemotherapy, 2009, Li, Hongyang; Walsh, Timothy R; Toleman, Mark A
Liquid-Phase Parallel Synthesis of Ureas
score: 1.0929142, Bioorganic & Medicinal Chemistry Letters, 2001, Huang, Kuo-Ting; Sun, Chung-Ming
Construction of arginine-rich peptide displaying bionanocapsules
score: 1.0928839, Bioorganic & Medicinal Chemistry Letters, 2009, Shishido, Takuya et. al.
Isolation of imipenem-resistant Enterobacter species: emergence of KPC-2 carbapenemase, molecular characterization, epidemiology, and outcomes.
score: 1.0928826, Antimicrobial agents and chemotherapy, 2008, Marchaim, Dror et. al.
Heterologous production of albicidin: a promising approach to overproducing and characterizing this potent inhibitor of DNA gyrase.
score: 1.0928712, Antimicrobial agents and chemotherapy, 2007, Vivien, Eric et. al.
Enzymatic synthesis of labeled DNA by PCR using new fluorescent thymidine nucleotide analogue and superthermophilic KOD dash DNA polymerase
score: 1.0928439, Bioorganic & Medicinal Chemistry Letters, 2002, Obayashi, Tsutomu et. al.
Production of KPC-2 carbapenemase by an Escherichia coli clinical isolate belonging to the international ST131 clone.
score: 1.0928427, Antimicrobial agents and chemotherapy, 2011, Morris, Dearbháile et. al.
SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam.
score: 1.0928159, Antimicrobial agents and chemotherapy, 2000, Yuan, M et. al.
Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae.
score: 1.0927757, Antimicrobial agents and chemotherapy, 2003, Montanari, Maria P et. al.
Sfh-I, a subclass B2 metallo-beta-lactamase from a Serratia fonticola environmental isolate.
score: 1.0927688, Antimicrobial agents and chemotherapy, 2003, Saavedra, Maria José et. al.
Peptide Conjugates as Tools for the Study of Biological Signal Transduction
score: 1.0927551, Bioorganic & Medicinal Chemistry, 1999, Eisele, Frank; Owen, David J; Waldmann, Herbert
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
score: 1.0927003, Antimicrobial agents and chemotherapy, 2005, Baraniak, Anna et. al.
The comparison of characteristics between membrane-active antifungal peptide and its pseudopeptides
score: 1.0925936, Bioorganic & Medicinal Chemistry, 1999, Oh, Jong Eun; Hong, Sung Yu; Lee, Keun-Hyeung
Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividans TK24
score: 1.0925611, Bioorganic & Medicinal Chemistry Letters, 2007, Subba, Bimala et. al.
Single-stranded DNA aptamers specific for antibiotics tetracyclines
score: 1.0925542, Bioorganic & Medicinal Chemistry, 2008, Niazi, Javed H.; Lee, Su Jin; Gu, Man Bock
Pharmacokinetics and pharmacodynamics of TBR-652, a novel CCR5 antagonist, in HIV-1-infected, antiretroviral treatment-experienced, CCR5 antagonist-naïve patients.
score: 1.0925386, Antimicrobial agents and chemotherapy, 2011, Marier, Jean-Francois et. al.
Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part I: Dioxygenated 4-Methyl Coumarins as Superb Antioxidant and Radical Scavenging Agents
score: 1.0925019, Bioorganic & Medicinal Chemistry, 1998, Raj, Hanumantharao G et. al.
Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA
score: 1.0924622, Bioorganic & Medicinal Chemistry Letters, 2009, Furman, Jennifer L. et. al.
Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection.
score: 1.0924375, Antimicrobial agents and chemotherapy, 2001, Jacobson, J M et. al.
Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P 1-arginine mimetics
score: 1.0924198, European Journal of Medicinal Chemistry, 2005, Kranjc, Andreja et. al.
Syntheses and biological activities of daunorubicin analogs with uncommon sugars
score: 1.092409, Bioorganic & Medicinal Chemistry, 2005, Zhu, Lizhi et. al.
Synergistic activity of colistin and ceftazidime against multiantibiotic-resistant Pseudomonas aeruginosa in an in vitro pharmacodynamic model.
score: 1.0923325, Antimicrobial agents and chemotherapy, 2003, Gunderson, Brent W et. al.
Time of incubation for antifungal susceptibility testing of Aspergillus fumigatus: can MIC values be obtained at 24 hours?
score: 1.092297, Antimicrobial agents and chemotherapy, 2007, Rodriguez-Tudela, Juan Luis et. al.
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands
score: 1.0922634, Bioorganic & Medicinal Chemistry, 2006, Lee, Jeewoo et. al.
In vitro antioxidant activity of acetylated and benzoylated derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta)
score: 1.0922394, Bioorganic & Medicinal Chemistry Letters, 2006, Qi, Huimin et. al.
Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme.
score: 1.0922274, Antimicrobial agents and chemotherapy, 2006, Park, Chi Hye et. al.
Metalated hybrid polymers as catalytic reagents for phosphate ester hydrolysis and plasmid modification
score: 1.0921892, Bioorganic & Medicinal Chemistry Letters, 2004, Chandrasekhar, Vadapalli et. al.
Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis.
score: 1.0921842, Antimicrobial agents and chemotherapy, 2003, Ramaswamy, Srinivas V et. al.
Equivalent steady-state pharmacokinetics of lamivudine in plasma and lamivudine triphosphate within cells following administration of lamivudine at 300 milligrams once daily and 150 milligrams twice daily.
score: 1.0921507, Antimicrobial agents and chemotherapy, 2004, Yuen, Geoffrey J et. al.
Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment.
score: 1.0921129, Antimicrobial agents and chemotherapy, 2009, Feuerriegel, Silke et. al.
Amphotericin B in lipid emulsion: stability, compatibility, and in vitro antifungal activity.
score: 1.0921127, Antimicrobial agents and chemotherapy, 1998, Walker, S et. al.
High Rate of qacA- and qacB-Positive Methicillin-Resistant Staphylococcus aureus Isolates from Chlorhexidine-Impregnated Catheter-Related Bloodstream Infections.
score: 1.0920956, Antimicrobial agents and chemotherapy, 2012, Ho, Cheng-Mao et. al.
Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis
score: 1.0920854, Bioorganic & Medicinal Chemistry, 2004, Wu, Pei-Lin; Chuang, Ta-Hsien; He, Cai-Xia; Wu, Tian-Shung
Extended-spectrum beta-lactamases and plasmid-mediated AmpC enzymes among clinical isolates of Escherichia coli and Klebsiella pneumoniae from seven medical centers in Taiwan.
score: 1.0920852, Antimicrobial agents and chemotherapy, 2006, Yan, Jing-Jou et. al.
Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
score: 1.0920634, European Journal of Medicinal Chemistry, 2012, Chavarria, Gustavo E. et. al.
Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
score: 1.0920634, European Journal of Medicinal Chemistry, 2012, Chavarria, Gustavo E. et. al.
Pharmacodynamic profile of ertapenem against Klebsiella pneumoniae and Escherichia coli in a murine thigh model.
score: 1.0920139, Antimicrobial agents and chemotherapy, 2005, Maglio, Dana et. al.
Variants of the Klebsiella pneumoniae OKP chromosomal beta-lactamase are divided into two main groups, OKP-A and OKP-B.
score: 1.0919758, Antimicrobial agents and chemotherapy, 2005, Fevre, Cindy et. al.
Rapid and simple phenotypic assay for drug susceptibility of human immunodeficiency virus type 1 using CCR5-expressing HeLa/CD4(+) cell clone 1-10 (MAGIC-5).
score: 1.0919535, Antimicrobial agents and chemotherapy, 2001, Hachiya, A et. al.
Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.
score: 1.0919335, Antimicrobial agents and chemotherapy, 2006, Dennis, Carly G et. al.
Characterization of vancomycin-resistant Enterococcus faecium isolates from the United States and their susceptibility in vitro to dalfopristin-quinupristin.
score: 1.09186, Antimicrobial agents and chemotherapy, 1998, Eliopoulos, G M et. al.
Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene.
score: 1.0918362, Antimicrobial agents and chemotherapy, 2005, Chou, Sunwen et. al.
3,3 ′-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group
score: 1.0918334, Bioorganic & Medicinal Chemistry Letters, 2004, Oka, Natsuhisa; Sanghvi, Yogesh S.; Theodorakis, Emmanuel A.
Glycosynthase-Catalysed syntheses at pH below neutrality
score: 1.0917895, Bioorganic & Medicinal Chemistry Letters, 2003, Trincone, Antonio et. al.
Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: Isolation, structure elucidation, and structure–activity relationship
score: 1.0917746, Bioorganic & Medicinal Chemistry, 2006, Uddin, Jasim et. al.
Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia.
score: 1.0917667, Antimicrobial agents and chemotherapy, 2006, Howden, Benjamin P et. al.
Low fitness cost of the multidrug resistance gene cfr.
score: 1.0917448, Antimicrobial agents and chemotherapy, 2011, LaMarre, Jacqueline M et. al.
Efficacy of cidofovir in a murine model of disseminated progressive vaccinia.
score: 1.0917061, Antimicrobial agents and chemotherapy, 2004, Neyts, Johan et. al.
Polyamines increase antibiotic susceptibility in Pseudomonas aeruginosa.
score: 1.0916886, Antimicrobial agents and chemotherapy, 2006, Kwon, Dong H; Lu, Chung-Dar
ColE1-like plasmid pIP843 of Klebsiella pneumoniae encoding extended-spectrum beta-lactamase CTX-M-17.
score: 1.0916384, Antimicrobial agents and chemotherapy, 2002, Cao, Van; Lambert, Thierry; Courvalin, Patrice
Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data.
score: 1.0916289, Antimicrobial agents and chemotherapy, 2012, Acosta, Edward P et. al.
Biological activity of an intravenous preparation of human vaccinia immune globulin in mouse models of vaccinia virus infection.
score: 1.0916091, Antimicrobial agents and chemotherapy, 2005, Shearer, Jeffry D et. al.
Antibiotic susceptibilities of genetically characterized Streptococcus milleri group strains.
score: 1.0915061, Antimicrobial agents and chemotherapy, 2001, Tracy, M et. al.
99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation
score: 1.0914223, European Journal of Medicinal Chemistry, 2012, Moura, Carolina et. al.
First description of CTX-M-15-producing Klebsiella pneumoniae in Portugal.
score: 1.0914098, Antimicrobial agents and chemotherapy, 2005, Conceição, T et. al.
Effect of carbon dioxide on testing of susceptibilities of respiratory tract pathogens to macrolide and azalide antimicrobial agents.
score: 1.0913733, Antimicrobial agents and chemotherapy, 1999, Johnson, M M; Hill, S L; Piddock, L J
Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species.
score: 1.091354, Antimicrobial agents and chemotherapy, 2006, Pankuch, Glenn A; Appelbaum, Peter C
Expression of efflux pump gene pmrA in fluoroquinolone-resistant and -susceptible clinical isolates of Streptococcus pneumoniae.
score: 1.0913235, Antimicrobial agents and chemotherapy, 2002, Piddock, Laura J V; Johnson, Maggie M; Simjee, S; Pumbwe, L
In vitro antifungal susceptibilities of Trichosporon species.
score: 1.0913203, Antimicrobial agents and chemotherapy, 2002, Paphitou, Niki I et. al.
Production and application of LPA polyclonal antibody
score: 1.09131, Bioorganic & Medicinal Chemistry Letters, 2000, Chen, Jia-hua et. al.
Mutations in the aph(2")-Ic gene are responsible for increased levels of aminoglycoside resistance.
score: 1.0912936, Antimicrobial agents and chemotherapy, 2002, Lee, Hae Kyung et. al.
Pattern of antimicrobial susceptibility obtained from blood isolates of a rare but emerging human pathogen, Gordonia polyisoprenivorans.
score: 1.0912764, Antimicrobial agents and chemotherapy, 2012, Moser, Benjamin D et. al.
pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal.
score: 1.0912354, Antimicrobial agents and chemotherapy, 2004, Portugal, Isabel et. al.
Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritis
score: 1.0912205, Bioorganic & Medicinal Chemistry, 2006, Holm, Lotta et. al.
Quantitative PCR assay to evaluate ampicillin, ofloxacin, and doxycycline for treatment of experimental leptospirosis.
score: 1.0911908, Antimicrobial agents and chemotherapy, 2002, Truccolo, Johann et. al.
gyrA and gyrB mutations are implicated in cross-resistance to Ciprofloxacin and moxifloxacin in Clostridium difficile.
score: 1.0911493, Antimicrobial agents and chemotherapy, 2002, Dridi, Larbi et. al.
Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides.
score: 1.0911129, Antimicrobial agents and chemotherapy, 2006, Wachino, Jun-Ichi et. al.
A colormetric assay for catechol- O-methyltransferase
score: 1.091026, Bioorganic & Medicinal Chemistry, 2004, Bailey, Karl; Cowling, Rebecca; Tan, Eng Wui; Webb, Daniel
Investigation of the interaction between amodiaquine and human serum albumin by fluorescence spectroscopy and molecular modeling
score: 1.0910108, European Journal of Medicinal Chemistry, 2012, Samari, Fayezeh et. al.
Investigation of the interaction between amodiaquine and human serum albumin by fluorescence spectroscopy and molecular modeling
score: 1.0910108, European Journal of Medicinal Chemistry, 2012, Samari, Fayezeh et. al.
Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus.
score: 1.0910059, Antimicrobial agents and chemotherapy, 2012, Slavetinsky, Christoph J et. al.
Activities of masked 2',3'-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophages.
score: 1.0909774, Antimicrobial agents and chemotherapy, 2000, Aquaro, S et. al.
Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones
score: 1.0909659, European Journal of Medicinal Chemistry, 2012, Mor, Satbir; Pahal, Preeti; Narasimhan, Balasubramanian
Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones
score: 1.0909659, European Journal of Medicinal Chemistry, 2012, Mor, Satbir; Pahal, Preeti; Narasimhan, Balasubramanian
Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones
score: 1.0909659, European Journal of Medicinal Chemistry, 2012, Mor, Satbir; Pahal, Preeti; Narasimhan, Balasubramanian
Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.
score: 1.0908662, Antimicrobial agents and chemotherapy, 2007, Ehrhardt, Stephan et. al.
Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India.
score: 1.0908662, Antimicrobial agents and chemotherapy, 2006, Ahmed, Anwar et. al.
Aerosolized cidofovir is retained in the respiratory tract and protects mice against intranasal cowpox virus challenge.
score: 1.0908338, Antimicrobial agents and chemotherapy, 2003, Roy, Chad J; Baker, Robert; Washburn, Kenneth; Bray, Mike
Asymmetric reduction of 3-aryl-3-keto esters using Rhizopus species
score: 1.0908003, Bioorganic & Medicinal Chemistry, 2006, Salvi, Neeta A.; Chattopadhyay, Subrata
gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
score: 1.0907945, Antimicrobial agents and chemotherapy, 1998, Weigel, L M; Steward, C D; Tenover, F C
Galactosylation with β-galactosidase from bovine testes employing modified acceptor substrates
score: 1.0907852, Bioorganic & Medicinal Chemistry, 1997, Gambert, Ulrike et. al.
Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4
score: 1.0907765, Bioorganic & Medicinal Chemistry Letters, 2012, Nguyen, Thi Thanh Binh et. al.
Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4
score: 1.0907765, Bioorganic & Medicinal Chemistry Letters, 2012, Nguyen, Thi Thanh Binh et. al.
Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4
score: 1.0907765, Bioorganic & Medicinal Chemistry Letters, 2012, Nguyen, Thi Thanh Binh et. al.
Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum
score: 1.0906954, Bioorganic & Medicinal Chemistry Letters, 1999, Nemoto, Hisao et. al.
Comparative pharmacodynamics of gatifloxacin and ciprofloxacin in an in vitro dynamic model: prediction of equiefficient doses and the breakpoints of the area under the curve/MIC ratio.
score: 1.0906903, Antimicrobial agents and chemotherapy, 2000, Vostrov, S N et. al.
Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Iq from the integron of a natural multiresistance plasmid.
score: 1.0905451, Antimicrobial agents and chemotherapy, 1998, Centrón, D; Roy, P H
Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.
score: 1.0905261, Antimicrobial agents and chemotherapy, 2012, Belser, Jessica A et. al.
Inhibitory activities of epidermal growth factor receptor tyrosine kinase-targeted dihydroxyisoflavone and trihydroxydeoxybenzoin derivatives on Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum development.
score: 1.0905014, Antimicrobial agents and chemotherapy, 2005, Gargala, G et. al.
Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation
score: 1.0904569, Bioorganic & Medicinal Chemistry, 2012, Kashida, Hiromu et. al.
Linezolid and vancomycin, alone and in combination with rifampin, compared with moxifloxacin against a multidrug-resistant and a vancomycin-tolerant Streptococcus pneumoniae strain in an in vitro pharmacodynamic model.
score: 1.0904085, Antimicrobial agents and chemotherapy, 2003, Cha, Raymond; Rybak, Michael J
Current prospects for the fluoroquinolones as first-line tuberculosis therapy.
score: 1.0903756, Antimicrobial agents and chemotherapy, 2011, Takiff, Howard; Guerrero, Elba
Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate.
score: 1.0903482, Antimicrobial agents and chemotherapy, 2001, Queenan, A M; Jenkins, S; Bush, K
Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions.
score: 1.0902585, Antimicrobial agents and chemotherapy, 2003, Wu, Jim Zhen; Walker, Heli; Lau, Johnson Y N; Hong, Zhi
Biosynthetic studies of spiroleptosphol
score: 1.0902015, Bioorganic & Medicinal Chemistry Letters, 2009, Murakami, Takanori; Takada, Noboru; Hashimoto, Masaru
Expansion and evolution of the Streptococcus pneumoniae Spain9V-ST156 clonal complex in Poland.
score: 1.0901846, Antimicrobial agents and chemotherapy, 2010, Sadowy, Ewa et. al.
Synthesis of sialyl lewis x pentasaccharide analogue for high-throughput screening of selectin blockers
score: 1.0901768, Bioorganic & Medicinal Chemistry, 1998, Kiyoi, Takao et. al.
Enhancement of antioxidant activity of p-alkylaminophenols by alkyl chain elongation
score: 1.0901685, Bioorganic & Medicinal Chemistry, 2003, Takahashi, Noriko et. al.
N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents
score: 1.090135, European Journal of Medicinal Chemistry, 2010, Olar, Rodica et. al.
N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents
score: 1.090135, European Journal of Medicinal Chemistry, 2010, Olar, Rodica et. al.
A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations
score: 1.0900567, Bioorganic & Medicinal Chemistry, 1996, Busby, Robert W; Townsend, Craig A
An improved model of the Aspergillus fumigatus CYP51A protein.
score: 1.0900563, Antimicrobial agents and chemotherapy, 2011, Fraczek, M G; Bromley, M; Bowyer, P
Therapeutic efficacies of GW471552 and GW471558, two new azasordarin derivatives, against pneumocystosis in two immunosuppressed-rat models.
score: 1.0900492, Antimicrobial agents and chemotherapy, 2002, Jimenez, Elena et. al.
Aeromonas hydrophila with plasmid-borne class A extended-spectrum beta-lactamase TEM-24 and three chromosomal class B, C, and D beta-lactamases, isolated from a patient with necrotizing fasciitis.
score: 1.0900485, Antimicrobial agents and chemotherapy, 2004, Fosse, T et. al.
Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.
score: 1.0900411, Antimicrobial agents and chemotherapy, 2003, Chen, Huachun et. al.
Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model.
score: 1.0900381, Antimicrobial agents and chemotherapy, 1999, Firsov, A A et. al.
Inhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide.
score: 1.0899809, Antimicrobial agents and chemotherapy, 2012, Donalisio, Manuela et. al.
Aminoglycoside and macrolide resistance in Burkholderia pseudomallei.
score: 1.0899322, Antimicrobial agents and chemotherapy, 1999, Simpson, A J; White, N J; Wuthiekanun, V
Generation of a reporter cell line for detection of infectious varicella-zoster virus and its application to antiviral studies.
score: 1.0898815, Antimicrobial agents and chemotherapy, 2006, Wang, Guan-Qing et. al.
Selection of naturally occurring extended-spectrum TEM beta-lactamase variants by fluctuating beta-lactam pressure.
score: 1.089871, Antimicrobial agents and chemotherapy, 2000, Blazquez, J; Morosini, M I; Negri, M C; Baquero, F
Changing Epidemiology of Extended-Spectrum β-Lactamases in Argentina: Emergence of CTX-M-15.
score: 1.0898692, Antimicrobial agents and chemotherapy, 2012, Sennati, S et. al.
Activity and diffusion of tigecycline (GAR-936) in experimental enterococcal endocarditis.
score: 1.0898329, Antimicrobial agents and chemotherapy, 2003, Lefort, Agnès et. al.
Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine.
score: 1.0898323, Antimicrobial agents and chemotherapy, 2011, Müller, Fabian et. al.
Efficacy of microencapsulated rifampin in Mycobacterium tuberculosis-infected mice.
score: 1.089673, Antimicrobial agents and chemotherapy, 1999, Quenelle, D C et. al.
Identification of an erm(A) erythromycin resistance methylase gene in Streptococcus pneumoniae isolated in Greece.
score: 1.0896044, Antimicrobial agents and chemotherapy, 2001, Syrogiannopoulos, G A et. al.
Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity
score: 1.0895387, Bioorganic & Medicinal Chemistry, 2006, Choi, Suk-June et. al.
Effects of quinones on free-radical processes of oxidation and fragmentation of hydroxyl-containing organic compounds
score: 1.0895111, Bioorganic & Medicinal Chemistry Letters, 2007, Shadyro, O.I. et. al.
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
score: 1.089417, Antimicrobial agents and chemotherapy, 2010, Kumagai, Takanori et. al.
Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities
score: 1.0893276, Bioorganic & Medicinal Chemistry, 2006, Morsy, Nagy et. al.
Effect of subinhibitory antibiotic concentrations on polysaccharide intercellular adhesin expression in biofilm-forming Staphylococcus epidermidis.
score: 1.0893181, Antimicrobial agents and chemotherapy, 2000, Rachid, S; Ohlsen, K; Witte, W; Hacker, J; Ziebuhr, W
Corticosteroids: the mainstay in asthma therapy
score: 1.0892863, Bioorganic & Medicinal Chemistry, 2004, Gupta, Ranju; Jindal, Dharam Paul; Kumar, Gulshan
Design, synthesis and structure–activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion
score: 1.0892375, European Journal of Medicinal Chemistry, 2012, Zhu, Zhibo et. al.
Vancomycin bactericidal activity as a predictor of 30-day mortality in patients with methicillin-resistant Staphylococcus aureus bacteremia.
score: 1.0892244, Antimicrobial agents and chemotherapy, 2011, Miyazaki, Motoyasu et. al.
Statistical methods for establishing quality control ranges for antibacterial agents in Clinical and Laboratory Standards Institute susceptibility testing.
score: 1.0891575, Antimicrobial agents and chemotherapy, 2007, Turnidge, John; Bordash, Gerry
Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B.
score: 1.0891229, Antimicrobial agents and chemotherapy, 2000, de Vrueh, R L et. al.
Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of imipenem in healthy rats.
score: 1.0890648, Antimicrobial agents and chemotherapy, 2001, Dupuis, A et. al.
Design and synthesis of dinucleotide 5′-triphosphates with expanded functionality
score: 1.0890425, Bioorganic & Medicinal Chemistry, 2008, Abramova, Tatiana V. et. al.
Inhibition of monoamine oxidase B by selective adenosine A 2A receptor antagonists
score: 1.0890352, Bioorganic & Medicinal Chemistry, 2003, Petzer, Jacobus P et. al.
Improved synthesis of the iodine-free thyromimetic GC-1
score: 1.0890263, Bioorganic & Medicinal Chemistry Letters, 2000, Chiellini, Grazia et. al.
Failure of vancomycin continuous infusion against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus.
score: 1.0890124, Antimicrobial agents and chemotherapy, 2011, Entenza, J M et. al.
Population pharmacokinetics of conventional and intermittent dosing of liposomal amphotericin B in adults: a first critical step for rational design of innovative regimens.
score: 1.0888474, Antimicrobial agents and chemotherapy, 2012, Hope, William W et. al.
Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae.
score: 1.0887554, Antimicrobial agents and chemotherapy, 2003, Balsalobre, Luz et. al.
In vivo muscarinic binding selectivity of (R,S)- and (R,R)- [ 18F]-Fluoromethyl QNB
score: 1.0885314, Bioorganic & Medicinal Chemistry, 1997, Kiesewetter, Dale O. et. al.
In vivo muscarinic binding selectivity of (R,S)- and (R,R)- [ 18F]-Fluoromethyl QNB
score: 1.0885314, Bioorganic & Medicinal Chemistry, 1997, Kiesewetter, Dale O. et. al.
In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces.
score: 1.0885271, Antimicrobial agents and chemotherapy, 2003, Raad, Issam et. al.
High prevalence of KPC-2-type carbapenemase coupled with CTX-M-type extended-spectrum beta-lactamases in carbapenem-resistant Klebsiella pneumoniae in a teaching hospital in China.
score: 1.0884811, Antimicrobial agents and chemotherapy, 2011, Chen, Shudan et. al.
Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5- d ]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
score: 1.0884153, Scientia Pharmaceutica, 2011, El-Moghazy, Samir M. et. al.
DBD dyes as fluorescent probes for sensing lipophilic environments
score: 1.0883863, Bioorganic & Medicinal Chemistry Letters, 2012, Wawrzinek, Robert et. al.
Efficacies of vesicular and free sodium stibogluconate formulations against clinical isolates of Leishmania donovani.
score: 1.0883799, Antimicrobial agents and chemotherapy, 2001, Carter, K C; Mullen, A B; Sundar, S; Kenney, R T
Pharmacokinetics, toxicities, and efficacies of sodium stibogluconate formulations after intravenous administration in animals.
score: 1.0883673, Antimicrobial agents and chemotherapy, 2003, Nieto, J et. al.
Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns.
score: 1.0883255, Antimicrobial agents and chemotherapy, 2002, Steinstraesser, Lars et. al.
Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).
score: 1.0882927, Antimicrobial agents and chemotherapy, 2002, Coque, Teresa M et. al.
The catecholic antioxidant piceatannol is an effective nitrosation inhibitor via an unusual double bond nitration
score: 1.0882896, Bioorganic & Medicinal Chemistry Letters, 2006, De Lucia, Maria et. al.
Population Pharmacokinetic and Pharmacodynamic Modeling of Amodiaquine and Desethylamodiaquine in Women with Plasmodium vivax Malaria during and after Pregnancy.
score: 1.0882516, Antimicrobial agents and chemotherapy, 2012, Tarning, Joel et. al.
Clinical strain of Pseudomonas aeruginosa carrying a bla(TEM-21) gene located on a chromosomal interrupted TnA type transposon.
score: 1.0882455, Antimicrobial agents and chemotherapy, 2002, Dubois, Véronique et. al.
Antibiotic resistance in bacteria isolated from subgingival plaque in a norwegian population with refractory marginal periodontitis.
score: 1.0881965, Antimicrobial agents and chemotherapy, 2003, Handal, Trude; Caugant, Dominique A; Olsen, Ingar
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs)
score: 1.0881626, Bioorganic & Medicinal Chemistry, 2003, Carpino, Philip A et. al.
N-terminal labeling of proteins by the Pictet–Spengler reaction
score: 1.0881462, Bioorganic & Medicinal Chemistry Letters, 2008, Sasaki, Tsubasa et. al.
Raltegravir concentrations in the genital tract of HIV-1-infected women treated with a raltegravir-containing regimen (DIVA 01 study).
score: 1.0881363, Antimicrobial agents and chemotherapy, 2011, Clavel, Cyril et. al.
Antibiotic tolerance induced by lactoferrin in clinical Pseudomonas aeruginosa isolates from cystic fibrosis patients.
score: 1.0881359, Antimicrobial agents and chemotherapy, 2005, Andrés, María T et. al.
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe
score: 1.0881119, Bioorganic & Medicinal Chemistry Letters, 2012, Delpire, Eric et. al.
An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages.
score: 1.0880908, Antimicrobial agents and chemotherapy, 2012, de Faria, Tatiany J et. al.
The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)2, d(CGATCG)2 and d(CGCGCG)2 shows a strong but reversible binding to G:C base pairs
score: 1.088046, Bioorganic & Medicinal Chemistry, 2012, Mazzini, Stefania et. al.
The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)2, d(CGATCG)2 and d(CGCGCG)2 shows a strong but reversible binding to G:C base pairs
score: 1.088046, Bioorganic & Medicinal Chemistry, 2012, Mazzini, Stefania et. al.
Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives
score: 1.0880081, Bioorganic & Medicinal Chemistry Letters, 2009, Islam, Rafique Ul et. al.
Genome-wide screening of Saccharomyces cerevisiae to identify genes required for antibiotic insusceptibility of eukaryotes.
score: 1.0880012, Antimicrobial agents and chemotherapy, 2003, Blackburn, Alexandra S; Avery, Simon V
Induction of resistance to azole drugs in Trypanosoma cruzi.
score: 1.0879997, Antimicrobial agents and chemotherapy, 1998, Buckner, F S; Wilson, A J; White, T C; Van Voorhis, W C
An exploratory theoretical elucidation on the peroxyl-radical-scavenging mechanism and structure–activity relationship of nonsteroidal anti-inflammatory drugs
score: 1.0879498, Bioorganic & Medicinal Chemistry Letters, 2006, Wang, Lan-fen; Song, Yu-guang; Zhang, Xiu-feng; Liu, Yang
Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants.
score: 1.0879376, Antimicrobial agents and chemotherapy, 1999, Van Bambeke, F et. al.
Integrated population pharmacokinetic analysis of voriconazole in children, adolescents, and adults.
score: 1.0878915, Antimicrobial agents and chemotherapy, 2012, Friberg, Lena E et. al.
Population pharmacokinetics and pharmacodynamic considerations of amodiaquine and desethylamodiaquine in Kenyan adults with uncomplicated malaria receiving artesunate-amodiaquine combination therapy.
score: 1.0878909, Antimicrobial agents and chemotherapy, 2010, Jullien, Vincent et. al.
Low Prevalence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates among Connecticut Veterans.
score: 1.0878314, Antimicrobial agents and chemotherapy, 2012, Fink, Susan L et. al.
Design of a selective chemical probe for class I PDZ domains
score: 1.0878273, Bioorganic & Medicinal Chemistry Letters, 2007, Fujii, Naoaki; Shelat, Anang; Hall, Randy A.; Kiplin Guy, R.
Synthesis of 4′-epi-iodo-4′-deoxy-daunorubicin, a potential cancer radiotherapeutic agent
score: 1.087728, Bioorganic & Medicinal Chemistry Letters, 1998, Murali, Dhanabalan; DeJesus, Onofre T.
Cellular signal-specific peptide substrate is essential for the gene delivery system responding to cellular signals
score: 1.0877057, Bioorganic & Medicinal Chemistry Letters, 2009, Kang, Jeong-Hun et. al.
Activity of Moxifloxacin, Imipenem, and Ertapenem against Escherichia coli, Enterobacter cloacae, Enterococcus faecalis, and Bacteroides fragilis in Monocultures and Mixed Cultures in an In Vitro Pharmacokinetic/Pharmacodynamic Model Simulating Concentrations in the Human Pancreas.
score: 1.0876576, Antimicrobial agents and chemotherapy, 2012, Schubert, Sabine; Dalhoff, Axel
Treatment of intra-abdominal abscesses caused by Candida albicans with antifungal agents and recombinant murine granulocyte colony-stimulating factor.
score: 1.087589, Antimicrobial agents and chemotherapy, 2003, Vonk, Alieke G et. al.
Efficient synthesis of 3-aminodigoxigenin and 3-aminodigitoxigenin probes
score: 1.0875445, Bioorganic & Medicinal Chemistry Letters, 1999, Adamczyk, Maciej; Grote, Jonathan
Immobilized oxazoline-containing Ligands in asymmetric catalysis—a review
score: 1.0875105, Bioorganic & Medicinal Chemistry Letters, 2002, Jönsson, Christina et. al.
Antibiotic susceptibility in neonatal invasive isolates of Streptococcus agalactiae in a 2-year nationwide surveillance study in Germany.
score: 1.0875036, Antimicrobial agents and chemotherapy, 2004, Fluegge, Kirsten et. al.
Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76.
score: 1.0874912, Antimicrobial agents and chemotherapy, 2010, Beshir, Khalid et. al.
Interaction of avilamycin with ribosomes and resistance caused by mutations in 23S rRNA.
score: 1.0874764, Antimicrobial agents and chemotherapy, 2002, Kofoed, Christine B; Vester, Birte
Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides
score: 1.0874005, European Journal of Medicinal Chemistry, 2006, Priya, B.S. et. al.
Role of superoxide in catalase-peroxidase-mediated isoniazid action against mycobacteria.
score: 1.087384, Antimicrobial agents and chemotherapy, 1998, Wang, J Y; Burger, R M; Drlica, K
Parallel RNA-strand recognition by 2′-amino-β- l-LNA
score: 1.0873053, Bioorganic & Medicinal Chemistry Letters, 2009, Kumar, T. Santhosh et. al.
Genetic screen for monitoring hepatitis C virus NS3 serine protease activity.
score: 1.0871693, Antimicrobial agents and chemotherapy, 2003, Martinez, Miguel Angel; Clotet, Bonaventura
Poly(I)-poly(C12U) but not ribavirin prevents death in a hamster model of Nipah virus infection.
score: 1.0871652, Antimicrobial agents and chemotherapy, 2006, Georges-Courbot, M C et. al.
Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.
score: 1.0871354, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Yunjiang et. al.
Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.
score: 1.0871354, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Yunjiang et. al.
The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae.
score: 1.0871116, Antimicrobial agents and chemotherapy, 2012, Jernigan, Meredith G et. al.
Efficacy of telithromycin (HMR 3647) against enterococci in a mouse peritonitis model.
score: 1.0870677, Antimicrobial agents and chemotherapy, 2000, Singh, K V; Zscheck, K K; Murray, B E
In vitro susceptibilities of 400 Spanish isolates of Neisseria gonorrhoeae to gemifloxacin and 11 other antimicrobial agents.
score: 1.0870359, Antimicrobial agents and chemotherapy, 2000, Berrón, S et. al.
DNA cleavage by pentadentate iron(II) complexes containing fluoro-substituted phenyl groups
score: 1.0870114, Bioorganic & Medicinal Chemistry Letters, 2002, Kurosaki, Hiromasa et. al.
The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans.
score: 1.0870109, Antimicrobial agents and chemotherapy, 2010, Ouyang, Jing et. al.
Proteins Markovian 3D-QSAR with spherically-truncated average electrostatic potentials
score: 1.0869609, Bioorganic & Medicinal Chemistry, 2005, Saı́z-Urra, Liane et. al.
Enhancing the synthetic utility of aldolase antibody 38C2
score: 1.0869431, Bioorganic & Medicinal Chemistry Letters, 2006, Mondal, Kalyani et. al.
The mef(A) gene predominates among seven macrolide resistance genes identified in gram-negative strains representing 13 genera, isolated from healthy Portuguese children.
score: 1.0868982, Antimicrobial agents and chemotherapy, 2004, Ojo, K K et. al.
In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78.
score: 1.0868207, Antimicrobial agents and chemotherapy, 2010, Duthaler, Urs; Smith, Thomas A; Keiser, Jennifer
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.
score: 1.086757, Antimicrobial agents and chemotherapy, 2005, Hata, Mami et. al.
Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on d-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages
score: 1.0867451, Bioorganic & Medicinal Chemistry, 2006, Yoshikawa, Masayuki et. al.
NMR evaluation of adipocyte fatty acid binding protein (aP2) with R- and S-ibuprofen
score: 1.0867363, Bioorganic & Medicinal Chemistry, 2008, Bai, Guoyun; Mo, Huaping; Shapiro, Michael
Characterization of a variant of vga(A) conferring resistance to streptogramin A and related compounds.
score: 1.0867358, Antimicrobial agents and chemotherapy, 2000, Haroche, J; Allignet, J; Buchrieser, C; El Solh, N
Macrolides and β-Lactam Antibiotics Enhance C3b Deposition on the Surface of Multidrug-Resistant Streptococcus pneumoniae Strains by a LytA Autolysin-Dependent Mechanism.
score: 1.0867269, Antimicrobial agents and chemotherapy, 2012, Ramos-Sevillano, Elisa et. al.
Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus.
score: 1.0866762, Antimicrobial agents and chemotherapy, 2002, Roilides, Emmanuel et. al.
Improved outcomes with linezolid for methicillin-resistant Staphylococcus aureus infections: better drug or reduced vancomycin susceptibility?
score: 1.0866416, Antimicrobial agents and chemotherapy, 2005, Howden, Benjamin P et. al.
In vitro antimicrobial susceptibility testing of Helicobacter felis, H. bizzozeronii, and H. salomonis.
score: 1.0865728, Antimicrobial agents and chemotherapy, 2005, Van den Bulck, K et. al.
Vancomycin tolerance in methicillin-resistant Staphylococcus aureus: influence of vancomycin, daptomycin, and telavancin on differential resistance gene expression.
score: 1.0865524, Antimicrobial agents and chemotherapy, 2012, Rose, Warren E et. al.
Effects of voriconazole on Cryptococcus neoformans.
score: 1.08654, Antimicrobial agents and chemotherapy, 2004, van Duin, David et. al.
Stereoselective synthesis of a C-glycoside analogue of N-Fmoc-serine β- N-acetylglucosaminide by ramberg–bäcklund rearrangement
score: 1.0864521, Bioorganic & Medicinal Chemistry Letters, 2002, Ohnishi, Yuki; Ichikawa, Yoshitaka
The use of small molecule probes to study spatially separated stimulus-induced signaling pathways
score: 1.0864349, Bioorganic & Medicinal Chemistry Letters, 2012, Kravchenko, Vladimir V. et. al.
Synthesis and evaluation of [ 14C]-Labelled and fluorescent-Tagged paclitaxel derivatives as new biological probes
score: 1.0863362, Bioorganic & Medicinal Chemistry, 1998, Rao, Ch.Srinivasa et. al.
Comparative bacteriostatic and bactericidal activities of cefodizime against Borrelia burgdorferi sensu lato.
score: 1.0861502, Antimicrobial agents and chemotherapy, 1999, Murgia, R; Marchetti, F; Cinco, M
Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study.
score: 1.0860317, Antimicrobial agents and chemotherapy, 2003, Farrell, D J et. al.
Activities of ABT-773 against microaerophilic and fastidious organisms.
score: 1.0860232, Antimicrobial agents and chemotherapy, 2002, Finegold, Sydney M et. al.
Propensity of fluoroquinolones with different moieties at position 8 to cause resistance development in clinical isolates of Streptococcus pneumoniae.
score: 1.0860194, Antimicrobial agents and chemotherapy, 2001, Schmitz, F J et. al.
Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes.
score: 1.0859909, Antimicrobial agents and chemotherapy, 2003, Marchetti, Oscar et. al.
Characterization of pUO-StVR2, a virulence-resistance plasmid evolved from the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium.
score: 1.085979, Antimicrobial agents and chemotherapy, 2008, Herrero, Ana et. al.
1,4,8-Trimethylfuro[2,3- H]quinolin-2(1 H)-one, a new furocoumarin bioisoster
score: 1.0859311, European Journal of Medicinal Chemistry, 2004, Marzano, Cristina et. al.
Effective discrimination of antimalarial potency of artemisinin compounds based on quantum chemical calculations of their reaction mechanism
score: 1.0859203, Bioorganic & Medicinal Chemistry, 2006, Tonmunphean, Somsak; Parasuk, Vudhichai; Kokpol, Sirirat
A novel bifunctional maleimido CHX-A″ chelator for conjugation to thiol-containing biomolecules
score: 1.0859103, Bioorganic & Medicinal Chemistry Letters, 2008, Xu, Heng et. al.
The synthesis, spectroscopic, X-ray characterization and in vitro cytotoxic testing results of activity of five new trans-platinum(IV) complexes with functionalized pyridines
score: 1.0858846, European Journal of Medicinal Chemistry, 2012, Rakić, Gordana M. et. al.
Effect of phosphonated carbocyclic 2'-oxa-3'-aza-nucleoside on human T-cell leukemia virus type 1 infection in vitro.
score: 1.0857574, Antimicrobial agents and chemotherapy, 2008, Balestrieri, Emanuela et. al.
Levofloxacin-resistant Streptococcus pneumoniae: second look.
score: 1.085738, Antimicrobial agents and chemotherapy, 2001, Thornsberry, C; Karlowsky, J A; Sahm, D F
Effect of treatment duration on pharmacokinetic/pharmacodynamic indices correlating with therapeutic efficacy of ceftazidime in experimental Klebsiella pneumoniae lung infection.
score: 1.0856074, Antimicrobial agents and chemotherapy, 2006, Bakker-Woudenberg, Irma A J M et. al.
Detection of a VIM-27-producing Klebsiella pneumoniae isolate in a patient following surgical tourism in Greece.
score: 1.08557, Antimicrobial agents and chemotherapy, 2011, Bogaerts, P et. al.
Phagocytosis affects biguanide sensitivity of Acanthamoeba spp.
score: 1.0855035, Antimicrobial agents and chemotherapy, 2002, Noble, Judith A et. al.
New dsDNA binding unnatural oligopeptides with pyrimidine selectivity
score: 1.0854652, Bioorganic & Medicinal Chemistry, 2002, Zhang, Zhenyu et. al.
Population pharmacokinetics of indinavir in patients infected with human immunodeficiency virus.
score: 1.0854463, Antimicrobial agents and chemotherapy, 2004, Csajka, Chantal et. al.
First isolation of blaIMI-2 in an Enterobacter cloacae clinical isolate from China.
score: 1.0854361, Antimicrobial agents and chemotherapy, 2006, Yu, Yun-Song et. al.
Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: Preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core
score: 1.0853939, Bioorganic & Medicinal Chemistry Letters, 2012, Harini, Salakatte Thammaiah et. al.
Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: Preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core
score: 1.0853939, Bioorganic & Medicinal Chemistry Letters, 2012, Harini, Salakatte Thammaiah et. al.
Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: Preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core
score: 1.0853939, Bioorganic & Medicinal Chemistry Letters, 2012, Harini, Salakatte Thammaiah et. al.
Quantitation of azoles and echinocandins in compartments of peripheral blood by liquid chromatography-tandem mass spectrometry.
score: 1.0853631, Antimicrobial agents and chemotherapy, 2010, Farowski, Fedja et. al.
A novel biotinylated suicide inhibitor for directed molecular evolution of lipolytic enzymes
score: 1.0853328, Bioorganic & Medicinal Chemistry, 2000, Deussen, H.-J.; Danielsen, S.; Breinholt, J.; Borchert, T.V.
A practical guide to measuring mutation rates in antibiotic resistance.
score: 1.0853078, Antimicrobial agents and chemotherapy, 2008, Pope, Cassie F et. al.
Effect of PTX3 and Voriconazole Combination in a Rat Model of Invasive Pulmonary Aspergillosis.
score: 1.085263, Antimicrobial agents and chemotherapy, 2012, Lo Giudice, Pietro et. al.
Polymyxin B-Resistant Acinetobacter baumannii Clinical Isolate Susceptible to Recombinant BPI and Cecropin P1.
score: 1.0852044, Antimicrobial agents and chemotherapy, 2001, Urban, C et. al.
Prevalence of tetracycline resistance genes in oral bacteria.
score: 1.0851946, Antimicrobial agents and chemotherapy, 2003, Villedieu, A et. al.
Carbonic anhydrase inhibitors. Part 60 # # See ref. [1] . The topical intraocular pressure-lowering properties of metal complexes of a heterocyclic sulfonamide: influence of the metal ion upon biological activity
score: 1.0851874, European Journal of Medicinal Chemistry, 1999, Supuran, Claudiu T. et. al.
The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.
score: 1.0851829, Antimicrobial agents and chemotherapy, 1998, Gustafson, E A; Chillemi, A C; Sage, D R; Fingeroth, J D
A novel type of AmpC beta-lactamase, ACC-1, produced by a Klebsiella pneumoniae strain causing nosocomial pneumonia.
score: 1.0851593, Antimicrobial agents and chemotherapy, 1999, Bauernfeind, A et. al.
Relevance of theoretical molecular descriptors in quantitative structure–activity relationship analysis of α1-adrenergic receptor antagonists
score: 1.0850946, Bioorganic & Medicinal Chemistry, 1999, Menziani, M.C. et. al.
Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals.
score: 1.0850789, Antimicrobial agents and chemotherapy, 2001, Leneva, I A et. al.
Enzymatic polymerisation involving 2′-amino-LNA nucleotides
score: 1.0849967, Bioorganic & Medicinal Chemistry Letters, 2012, Johannsen, Marie W. et. al.
Enzymatic polymerisation involving 2′-amino-LNA nucleotides
score: 1.0849967, Bioorganic & Medicinal Chemistry Letters, 2012, Johannsen, Marie W. et. al.
Phenolic glycosides, a new class of human recombinant nucleotide pyrophosphatase phosphodiesterase-1 inhibitors
score: 1.0848875, Bioorganic & Medicinal Chemistry, 2004, Choudhary, Muhammad Iqbal et. al.
New class of potent antinociceptive and antiplatelet 10 H-phenothiazine-1-acylhydrazone derivatives
score: 1.0847771, Bioorganic & Medicinal Chemistry, 2004, Silva, Gildásio A. et. al.
DNA binding and DNA cleavage studies of a water soluble cobalt(II) complex containing dinitrogen Schiff base ligand: The effect of metal on the mode of binding
score: 1.0847064, European Journal of Medicinal Chemistry, 2010, Shahabadi, Nahid; Kashanian, Soheila; Darabi, Farivash
Synthesis and TNF-α inducing activities of mycoloyl-arabinan motif of mycobacterial cell wall components
score: 1.0847016, Bioorganic & Medicinal Chemistry, 2006, Ishiwata, Akihiro et. al.
Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents
score: 1.0846546, European Journal of Medicinal Chemistry, 2010, Pavan, Fernando R. et. al.
Role of silver ions in destabilization of intermolecular adhesion forces measured by atomic force microscopy in Staphylococcus epidermidis biofilms.
score: 1.0846445, Antimicrobial agents and chemotherapy, 2005, Chaw, K C; Manimaran, M; Tay, Francis E H
Highly Resistant Salmonella enterica Serovar Typhi with a Novel gyrA Mutation Raises Questions about the Long-Term Efficacy of Older Fluoroquinolones for Treating Typhoid Fever.
score: 1.0846355, Antimicrobial agents and chemotherapy, 2012, Koirala, Kanika Deshpande et. al.
Incorporation of (2 S,3 S) and (2 S,3 R) β-Methyl aspartic acid into RGD-Containing peptides
score: 1.0845587, Bioorganic & Medicinal Chemistry, 2002, Schabbert, Silke et. al.
Inducible macrolide resistance in Corynebacterium jeikeium.
score: 1.0844793, Antimicrobial agents and chemotherapy, 2001, Rosato, A E; Lee, B S; Nash, K A
14β-Hydroxy-10-deacetylbaccatin III as a convenient, alternative substrate for the improved synthesis of methoxylated second-generation taxanes
score: 1.0844751, Bioorganic & Medicinal Chemistry Letters, 2006, Barboni, Luciano et. al.
Comparison of E test to microdilution for determining in vitro activities of antibiotics against Brucella melitensis.
score: 1.0844663, Antimicrobial agents and chemotherapy, 1999, Gür, D; Kocagöz, S; Akova, M; Unal, S
Combination echinocandin-polyene treatment of murine mucormycosis.
score: 1.0844046, Antimicrobial agents and chemotherapy, 2008, Ibrahim, Ashraf S et. al.
Phage therapy of Pseudomonas aeruginosa infection in a mouse burn wound model.
score: 1.0843958, Antimicrobial agents and chemotherapy, 2007, McVay, Catherine S; Velásquez, Marisela; Fralick, Joe A
Safety of voriconazole in a patient with CYP2C9*2/CYP2C9*2 genotype.
score: 1.0843666, Antimicrobial agents and chemotherapy, 2006, Geist, Marcus J P et. al.
Binding affinity of Cu(II)–VP-16 (etoposide) complex and its analogues to DNA and hydroxyl radical generation During DNA strand breaks
score: 1.0843646, Bioorganic & Medicinal Chemistry, 1998, Tawa, Riichi et. al.
Synthesis and anti-HIV evaluation of 2′,3′-dideoxy imidazo- and ν-triazolo[4,5- d]pyridazine nucleosides
score: 1.0843178, Bioorganic & Medicinal Chemistry, 1999, Bussolari, Jacqueline C.; Panzica, Raymond P.
Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.
score: 1.0842664, Antimicrobial agents and chemotherapy, 1999, Gill, M J; Brenwald, N P; Wise, R
Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.
score: 1.084266, Antimicrobial agents and chemotherapy, 2005, Newton, Paul N et. al.
Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program, 2000.
score: 1.084226, Antimicrobial agents and chemotherapy, 2002, Pfaller, M A et. al.
Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives
score: 1.0842163, Bioorganic & Medicinal Chemistry, 2008, Chang, Yu-Cheng et. al.
Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.
score: 1.0842102, Antimicrobial agents and chemotherapy, 2003, Wang, Hui et. al.
Identification of the minimal active sequence of an anti-influenza virus peptide.
score: 1.0841999, Antimicrobial agents and chemotherapy, 2011, Jones, Jeremy C et. al.
Susceptibilities of Yersinia pestis strains to 12 antimicrobial agents.
score: 1.0840265, Antimicrobial agents and chemotherapy, 2000, Wong, J D; Barash, J R; Sandfort, R F; Janda, J M
Synthesis and spectroscopy of Co II, Ni II, Cu II and Zn II complexes derived from 3,5-disubstituted-1 H-pyrazole derivative: A special emphasis on DNA binding and cleavage studies
score: 1.0840255, European Journal of Medicinal Chemistry, 2010, Budagumpi, Srinivasa et. al.
Molecular evaluation of antibiotic susceptibility: Tropheryma whipplei paradigm.
score: 1.0839927, Antimicrobial agents and chemotherapy, 2003, Masselot, F; Boulos, A; Maurin, M; Rolain, J M; Raoult, D
Systematic study on the broad nucleotide triphosphate specificity of the pyrophosphorylase domain of the N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli K12
score: 1.0839768, Bioorganic & Medicinal Chemistry Letters, 2009, Fang, Junqiang et. al.
Incorporation of a 4-hydroxy- N-acetylprolinol nucleotide analogue improves the 3′-exonuclease stability of 2′-5′-oligoadenylate-antisense conjugates
score: 1.0839625, Bioorganic & Medicinal Chemistry Letters, 2000, Verheijen, Jeroen C et. al.
Flucytosine resistance is restricted to a single genetic clade of Candida albicans.
score: 1.0839559, Antimicrobial agents and chemotherapy, 2004, Pujol, Claude; Pfaller, Michael A; Soll, David R
High prevalence of antimicrobial resistance in rapidly growing mycobacteria in Taiwan.
score: 1.0839554, Antimicrobial agents and chemotherapy, 2003, Yang, Shun-Cheng et. al.
NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2.
score: 1.0839317, Antimicrobial agents and chemotherapy, 2003, Sinha, Sara et. al.
The class A β-lactamase FTU-1 is native to Francisella tularensis.
score: 1.0839136, Antimicrobial agents and chemotherapy, 2012, Antunes, Nuno T et. al.
Anti-allergic substances from the rhizomes of Dioscorea membranacea
score: 1.0838995, Bioorganic & Medicinal Chemistry, 2006, Tewtrakul, Supinya; Itharat, Arunporn
Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.
score: 1.0838933, Antimicrobial agents and chemotherapy, 2008, Scheetz, Marc H et. al.
Antioxidant properties of violacein: Possible relation on its biological function
score: 1.0838908, Bioorganic & Medicinal Chemistry, 2006, Konzen, Marlon et. al.
Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan.
score: 1.0837831, Antimicrobial agents and chemotherapy, 2004, Wachino, Jun-ichi et. al.
Pharmacokinetic profiles of high-dose intravenous ciprofloxacin in severe sepsis. The Baragwanath Ciprofloxacin Study Group.
score: 1.0837529, Antimicrobial agents and chemotherapy, 1998, Lipman, J; Scribante, J; Gous, A G; Hon, H; Tshukutsoane, S
Characterization of emeA, a NorA homolog and multidrug resistance efflux pump, in Enterococcus faecalis.
score: 1.08373, Antimicrobial agents and chemotherapy, 2001, Jonas, B M; Murray, B E; Weinstock, G M
SELEX for Tubulin Affords Specific T-Rich DNA Aptamers
score: 1.0836114, Bioorganic & Medicinal Chemistry Letters, 2001, Fukusaki, Ei-ichiro et. al.
Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides
score: 1.083517, Bioorganic & Medicinal Chemistry, 2006, Anderson, Alan J. et. al.
New susceptibility breakpoints for first-line antituberculosis drugs based on antimicrobial pharmacokinetic/pharmacodynamic science and population pharmacokinetic variability.
score: 1.083474, Antimicrobial agents and chemotherapy, 2010, Gumbo, Tawanda
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
score: 1.0834595, Antimicrobial agents and chemotherapy, 2011, Bogaerts, Pierre et. al.
DNA aptamers that bind to chitin
score: 1.0833487, Bioorganic & Medicinal Chemistry Letters, 2000, Fukusaki, Ei-ichiro et. al.
Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.
score: 1.0832724, Antimicrobial agents and chemotherapy, 2003, Huang, Tsi-Shu et. al.
Isolation and expression of a novel molecular class D beta-lactamase, OXA-61, from Campylobacter jejuni.
score: 1.0832473, Antimicrobial agents and chemotherapy, 2005, Alfredson, David A; Korolik, Victoria
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.
score: 1.0831059, Antimicrobial agents and chemotherapy, 2001, Yano, H et. al.
Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT.
score: 1.0829734, Antimicrobial agents and chemotherapy, 2002, Loemba, Hugues et. al.
Novel mobile variants of staphylococcal cassette chromosome mec in Staphylococcus aureus.
score: 1.0829669, Antimicrobial agents and chemotherapy, 2006, Jansen, W T M et. al.
Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides
score: 1.0828475, Bioorganic & Medicinal Chemistry, 2007, Nuti, Francesca et. al.
Lack of allergic cross-reactivity between fluconazole and voriconazole.
score: 1.0827579, Antimicrobial agents and chemotherapy, 2009, Pinto, Angie; Chan, Raymond C
High-throughput and facile assay of antimicrobial peptides using pH-controlled fluorescence resonance energy transfer.
score: 1.0827455, Antimicrobial agents and chemotherapy, 2006, Kim, Young Soo; Cha, Hyung Joon
Evidence for dynamics in proteins as a mechanism for ligand dissociation
score: 1.0827289, Nature Chemical Biology, 2011, Carroll, Mary J. et. al.
Enhanced production of farnesol by Candida albicans treated with four azoles.
score: 1.0826176, Antimicrobial agents and chemotherapy, 2004, Hornby, Jacob M; Nickerson, Kenneth W
Synthesis and enzymatic evaluation of a P 1 arginine aminocoumarin substrate library for trypsin-like serine proteases
score: 1.0826094, Bioorganic & Medicinal Chemistry Letters, 2000, Edwards, Philip D. et. al.
Conservative secondary structure motif of streptavidin-binding aptamers generated by different laboratories
score: 1.0825745, Bioorganic & Medicinal Chemistry, 2010, Bing, Tao et. al.
Enzymatic detachment of Staphylococcus epidermidis biofilms.
score: 1.082531, Antimicrobial agents and chemotherapy, 2004, Kaplan, Jeffrey B et. al.
Survey of plasmid-associated genetic markers in enterobacteriaceae with reduced susceptibilities to cephalosporins.
score: 1.0824059, Antimicrobial agents and chemotherapy, 2003, Preston, Karen E et. al.
The K101P and K103R/V179D mutations in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nonnucleoside reverse transcriptase inhibitors.
score: 1.0823719, Antimicrobial agents and chemotherapy, 2006, Parkin, Neil T et. al.
Increasing prevalence and diversity of metallo-beta-lactamases in Pseudomonas spp., Acinetobacter spp., and Enterobacteriaceae from Korea.
score: 1.0823686, Antimicrobial agents and chemotherapy, 2006, Yong, Dongeun et. al.
Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro.
score: 1.0823406, Antimicrobial agents and chemotherapy, 2008, Malet, Isabelle et. al.
Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
score: 1.0823315, BMC Bioinformatics, 2011, John, Shalini et. al.
Photodynamic activity of water-soluble phthalocyanine zinc(II) complexes against pathogenic microorganisms
score: 1.0822658, Bioorganic & Medicinal Chemistry, 2007, Mantareva, Vanya et. al.
Antibody array-generated profiles of cytokine release from THP-1 leukemic monocytes exposed to different amphotericin B formulations.
score: 1.0822043, Antimicrobial agents and chemotherapy, 2004, Turtinen, Lloyd W et. al.
Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro.
score: 1.0821838, Antimicrobial agents and chemotherapy, 2006, Martinez, Luis R; Casadevall, Arturo
Cleavage and protection of locked nucleic acid–modified DNA by restriction endonucleases
score: 1.0821411, Bioorganic & Medicinal Chemistry Letters, 2012, Crouzier, Lucile et. al.
Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals
score: 1.0821206, Bioorganic & Medicinal Chemistry, 2003, Du, Wu et. al.
Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs
score: 1.0820782, European Journal of Medicinal Chemistry, 2009, Vale, Nuno et. al.
Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones
score: 1.0820448, European Journal of Medicinal Chemistry, 2012, Mor, Satbir; Pahal, Preeti; Narasimhan, Balasubramanian
Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids
score: 1.0820104, Bioorganic & Medicinal Chemistry, 2010, Svobodová, Hana et. al.
Reassessment of Clostridium difficile susceptibility to metronidazole and vancomycin.
score: 1.0819859, Antimicrobial agents and chemotherapy, 2002, Peláez, T et. al.
In vitro activity of telithromycin against viridans group streptococci and Streptococcus bovis isolated from blood: antimicrobial susceptibility patterns in different groups of species.
score: 1.0819823, Antimicrobial agents and chemotherapy, 2005, Rodríguez-Avial, Iciar et. al.
Wake-promoting agents: Search for next generation modafinil: Part IV
score: 1.0819728, European Journal of Medicinal Chemistry, 2012, Louvet, Philippe et. al.
Distribution of lipid formulations of amphotericin B into bone marrow and fat tissue in rabbits.
score: 1.0819702, Antimicrobial agents and chemotherapy, 2000, Groll, A H; Mickiene, D; Piscitelli, S C; Walsh, T J
In vitro susceptibility testing of Borrelia burgdorferi sensu lato isolates cultured from patients with erythema migrans before and after antimicrobial chemotherapy.
score: 1.0819069, Antimicrobial agents and chemotherapy, 2005, Hunfeld, Klaus-Peter et. al.
Susceptibilities of Eikenella corrodens, Prevotella intermedia, and Prevotella nigrescens clinical isolates to amoxicillin and tetracycline.
score: 1.0818509, Antimicrobial agents and chemotherapy, 2001, Luong, N; Tsai, J; Chen, C
Plasmid content of a vancomycin-resistant Enterococcus faecalis isolate from a patient also colonized by Staphylococcus aureus with a VanA phenotype.
score: 1.0817765, Antimicrobial agents and chemotherapy, 2003, Flannagan, Susan E et. al.
Studies of in vitro activities of voriconazole and itraconazole against Aspergillus hyphae using viability staining.
score: 1.0817716, Antimicrobial agents and chemotherapy, 2001, Lass-Flörl, C et. al.
Extensive genetic diversity in the Plasmodium falciparum Na+/H+ exchanger 1 transporter protein implicated in quinine resistance.
score: 1.0817684, Antimicrobial agents and chemotherapy, 2007, Vinayak, Sumiti et. al.
Fluorescence quenching of parallel-stranded DNA bound ethidium bromide: the effect of 7-deaza-2′-deoxyisoguanosine and 7-halogenated derivatives
score: 1.0817563, Bioorganic & Medicinal Chemistry Letters, 2004, Li, Hong; Peng, Xiaohua; Seela, Frank
Synthesis and evaluation of a novel lipid–peptide conjugate for functionalized liposome
score: 1.0817429, Bioorganic & Medicinal Chemistry Letters, 2007, Yagi, Nobuhiro et. al.
Synthesis and Hybridization Properties of DNA–PNA Chimeras Carrying 5-Bromouracil and 5-Methylcytosine
score: 1.0817034, Bioorganic & Medicinal Chemistry, 2000, Ferrer, Elisenda; Shevchenko, Anna; Eritja, Ramon
Synthesis and structure–Activity data of some new epibatidine analogues
score: 1.0815641, Bioorganic & Medicinal Chemistry, 1998, Seerden, Jean-Paul G. et. al.
Prevalence and mechanisms of macrolide resistance in invasive and noninvasive group B streptococcus isolates from Ontario, Canada.
score: 1.0815166, Antimicrobial agents and chemotherapy, 2001, de Azavedo, J C; McGavin, M; Duncan, C; Low, D E; McGeer, A
Systematic SAR study of the side chain of nonsecosteroidal vitamin D3 analogs
score: 1.0815128, Bioorganic & Medicinal Chemistry, 2012, Kashiwagi, Hirotaka et. al.
Systematic SAR study of the side chain of nonsecosteroidal vitamin D3 analogs
score: 1.0814725, Bioorganic & Medicinal Chemistry, 2012, Kashiwagi, Hirotaka et. al.
Failure of deferasirox, an iron chelator agent, combined with antifungals in a case of severe zygomycosis.
score: 1.0814697, Antimicrobial agents and chemotherapy, 2008, Soummer, Alexis et. al.
Molecular and biochemical characterization of Ambler class A extended-spectrum beta-lactamase CGA-1 from Chryseobacterium gleum.
score: 1.0814282, Antimicrobial agents and chemotherapy, 2002, Bellais, Samuel; Naas, Thierry; Nordmann, Patrice
Sublethal triclosan exposure decreases susceptibility to gentamicin and other aminoglycosides in Listeria monocytogenes.
score: 1.0813816, Antimicrobial agents and chemotherapy, 2011, Christensen, Ellen G; Gram, Lone; Kastbjerg, Vicky G
Mechanism of 17α-Hydroxylase/17,20-Lyase — An initial geometric perspective for the Lyase of the C(17)C(20) bond of C 21 steroids
score: 1.0813788, Bioorganic & Medicinal Chemistry Letters, 1998, Ahmed, Sabbir; Owen, Caroline P.
Enzymatic assay for measurement of intracellular DXG triphosphate concentrations in peripheral blood mononuclear cells from human immunodeficiency virus type 1-infected patients.
score: 1.0813175, Antimicrobial agents and chemotherapy, 2003, Kewn, Stephen et. al.
Mode of action of sulfanilyl fluoroquinolones.
score: 1.0813072, Antimicrobial agents and chemotherapy, 1998, Alovero, F; Nieto, M; Mazzieri, M R; Then, R; Manzo, R H
Synthesis, characterization and antidiabetic properties of N 1-2,4-dihydroxybenzylidene- N 4-2-hydroxybenzylidene- S-methyl-thiosemicarbazidato-oxovanadium(IV)
score: 1.0812789, European Journal of Medicinal Chemistry, 2009, Yanardag, Refiye et. al.
Effects of fresh garlic extract on Candida albicans biofilms.
score: 1.0812532, Antimicrobial agents and chemotherapy, 2005, Shuford, Jennifer A; Steckelberg, James M; Patel, Robin
Characterization of Hepatitis C Virus (HCV) Quasispecies Dynamics upon Short-Term Dual Therapy with the HCV NS5B Nucleoside Polymerase Inhibitor Mericitabine and the NS3/4 Protease Inhibitor Danoprevir.
score: 1.0812224, Antimicrobial agents and chemotherapy, 2012, Le Pogam, S et. al.
In vitro effectiveness of povidone-iodine on Acanthamoeba isolates from human cornea.
score: 1.0811925, Antimicrobial agents and chemotherapy, 1998, Gatti, S; Cevini, C; Bruno, A; Penso, G; Rama, P; Scaglia, M
Analysis of the topology of Vibrio cholerae NorM and identification of amino acid residues involved in norfloxacin resistance.
score: 1.0811883, Antimicrobial agents and chemotherapy, 2006, Singh, Anil Kumar et. al.
Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex
score: 1.0811492, Bioorganic & Medicinal Chemistry Letters, 2008, Chen, Xiaoqiang et. al.
Coordination of nitro-thiosemicarbazones to ruthenium(II) as a strategy for anti-trypanosomal activity improvement
score: 1.0811373, European Journal of Medicinal Chemistry, 2010, Rodrigues, Claudia et. al.
Coordination of nitro-thiosemicarbazones to ruthenium(II) as a strategy for anti-trypanosomal activity improvement
score: 1.0811373, European Journal of Medicinal Chemistry, 2010, Rodrigues, Claudia et. al.
Impact of silver-containing wound dressings on bacterial biofilm viability and susceptibility to antibiotics during prolonged treatment.
score: 1.0810412, Antimicrobial agents and chemotherapy, 2010, Kostenko, Victoria et. al.
Therapeutic effect of clarithromycin on a transplanted tumor in rats.
score: 1.0809312, Antimicrobial agents and chemotherapy, 1999, Sassa, K et. al.
In Vitro and In Vivo Antimicrobial Activities of Gallium Nitrate against Multidrug-Resistant Acinetobacter baumannii.
score: 1.0808813, Antimicrobial agents and chemotherapy, 2012, Antunes, Luísa C S et. al.
On the mechanism of demethylation of 5-methylcytosine in DNA
score: 1.0808515, Bioorganic & Medicinal Chemistry Letters, 2008, Hamm, Stefan et. al.
Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters.
score: 1.0808376, Antimicrobial agents and chemotherapy, 2004, Anton, Pauline M et. al.
Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998.
score: 1.0808321, Antimicrobial agents and chemotherapy, 2002, Carattoli, A et. al.
Eradication of bacteria in suspension and biofilms using methylene blue-loaded dynamic nanoplatforms.
score: 1.0808309, Antimicrobial agents and chemotherapy, 2009, Wu, Jianfeng et. al.
Development and validation of stability indicating HPLC and HPTLC methods for determination of sulpiride and mebeverine hydrochloride in combination
score: 1.0807291, European Journal of Medicinal Chemistry, 2010, Naguib, Ibrahim A.; Abdelkawy, Mohammed
Vibrio parahaemolyticus chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in Escherichia coli.
score: 1.0807148, Antimicrobial agents and chemotherapy, 2005, Saga, Tomoo et. al.
Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii
score: 1.0807029, Bioorganic & Medicinal Chemistry, 2002, He, Weidong et. al.
Double-blind, randomized study of the efficacy and safety of oral pharmacokinetically enhanced amoxicillin-clavulanate (2,000/125 milligrams) versus those of amoxicillin-clavulanate (875/125 milligrams), both given twice daily for 7 days, in treatment of bacterial community-acquired pneumonia in adults.
score: 1.0806934, Antimicrobial agents and chemotherapy, 2004, File, T M et. al.
In vivo activities of evernimicin (SCH 27899) against vancomycin-susceptible and vancomycin-resistant enterococci in experimental endocarditis.
score: 1.0806692, Antimicrobial agents and chemotherapy, 2000, Souli, M; Thauvin-Eliopoulos, C; Eliopoulos, G M
Molecular basis of resistance to macrolides and other antibiotics in commensal viridans group streptococci and Gemella spp. and transfer of resistance genes to Streptococcus pneumoniae.
score: 1.0806201, Antimicrobial agents and chemotherapy, 2004, Cerdá Zolezzi, Paula et. al.
Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center.
score: 1.0805923, Antimicrobial agents and chemotherapy, 2004, Woodford, Neil et. al.
Presence of mefA and mefE genes in Streptococcus agalactiae.
score: 1.0805907, Antimicrobial agents and chemotherapy, 1999, Arpin, C; Daube, H; Tessier, F; Quentin, C
Evaluation of T-3811ME (BMS-284756), a new des-F(6)-quinolone, for treatment of meningitis caused by penicillin-resistant Streptococcus pneumoniae in rabbits.
score: 1.0805622, Antimicrobial agents and chemotherapy, 2002, Takahata, Masahiro et. al.
Inhibitory activities of lansoprazole against respiration in Helicobacter pylori.
score: 1.0805054, Antimicrobial agents and chemotherapy, 2001, Nagata, K; Sone, N; Tamura, T
Epidemiological cutoff values for azoles and Aspergillus fumigatus based on a novel mathematical approach incorporating cyp51A sequence analysis.
score: 1.0804779, Antimicrobial agents and chemotherapy, 2012, Meletiadis, J et. al.
Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.
score: 1.0804495, Antimicrobial agents and chemotherapy, 2000, Masuda, N et. al.
An Escherichia coli O157-Specific Engineered Pyocin Prevents and Ameliorates Infection by E. coli O157:H7 in an Animal Model of Diarrheal Disease.
score: 1.0804268, Antimicrobial agents and chemotherapy, 2011, Ritchie, Jennifer M et. al.
Permeation of chlorhexidine from alcoholic and aqueous solutions within excised human skin.
score: 1.0804209, Antimicrobial agents and chemotherapy, 2009, Karpanen, T J et. al.
Evaluation of high- versus standard-dose rifampin in Indonesian patients with pulmonary tuberculosis.
score: 1.0802551, Antimicrobial agents and chemotherapy, 2006, Ruslami, Rovina et. al.
Unusual antimicrotubule activity of the antifungal agent spongistatin 1.
score: 1.0801807, Antimicrobial agents and chemotherapy, 1999, Ovechkina, Y Y et. al.
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand.
score: 1.0801763, Antimicrobial agents and chemotherapy, 2008, Magee, Wendy C et. al.
mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis.
score: 1.0801744, Antimicrobial agents and chemotherapy, 2005, Knobloch, Johannes K-M et. al.
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
score: 1.080126, Bioorganic & Medicinal Chemistry Letters, 2006, Vlahov, Iontcho R. et. al.
Functional cloning and characterization of a multidrug efflux pump, mexHI-opmD, from a Pseudomonas aeruginosa mutant.
score: 1.0801251, Antimicrobial agents and chemotherapy, 2003, Sekiya, Hiroshi et. al.
Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi.
score: 1.0801205, Antimicrobial agents and chemotherapy, 2006, Gomez, Maria J; Neyfakh, Alexander A
Zidovudine pharmacokinetics in premature infants exposed to human immunodeficiency virus.
score: 1.0800763, Antimicrobial agents and chemotherapy, 1998, Mirochnick, M et. al.
Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice.
score: 1.0800654, Antimicrobial agents and chemotherapy, 2001, Escobar, P; Yardley, V; Croft, S L
Flow cytometric assessment of susceptibilities of Streptococcus pyogenes to erythromycin and rokitamycin.
score: 1.0799975, Antimicrobial agents and chemotherapy, 2003, Braga, Pier Carlo et. al.
Radial Distribution Function descriptors for predicting affinity for vitamin D receptor
score: 1.0799917, European Journal of Medicinal Chemistry, 2008, González, Maykel Pérez et. al.
Flow cytometric detection of Leishmania parasites in human monocyte-derived macrophages: application to antileishmanial-drug testing.
score: 1.0799292, Antimicrobial agents and chemotherapy, 2000, Di Giorgio, C et. al.
Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol.
score: 1.0798513, Antimicrobial agents and chemotherapy, 2007, Miller, Christopher C et. al.
In vitro activities of posaconazole (Sch 56592) compared with those of itraconazole and fluconazole against 3,685 clinical isolates of Candida spp. and Cryptococcus neoformans.
score: 1.0798183, Antimicrobial agents and chemotherapy, 2001, Pfaller, M A; Messer, S A; Hollis, R J; Jones, R N
Activities of new fluoroquinolones against fluoroquinolone-resistant pathogens of the lower respiratory tract.
score: 1.0797428, Antimicrobial agents and chemotherapy, 1998, Piddock, L J; Johnson, M; Ricci, V; Hill, S L
Pharmacokinetics and pharmacodynamics of cefpirome in subcutaneous adipose tissue of septic patients.
score: 1.0797005, Antimicrobial agents and chemotherapy, 2005, Sauermann, Robert et. al.
Design, synthesis and in vivo anticonvulsant screening in mice of Novel phenylacetamides
score: 1.0796814, European Journal of Medicinal Chemistry, 2006, Shindikar, A.V.; Khan, F.; Viswanathan, C.L.
Prevention of the cryptic epitope SLAYGLR within osteopontin does not influence susceptibility to Candida albicans infection.
score: 1.0796432, Antimicrobial agents and chemotherapy, 2005, Sato, Ikuko et. al.
Biomimetic synthesis and ultrastructural characterization of a zerovalent gold–hydroxyapatite composite
score: 1.0796314, Bioorganic & Medicinal Chemistry Letters, 2006, Gupta, Yogita; Mathur, G.N.; Verma, Sandeep
Activities of therapeutic agents and myristamidopropyl dimethylamine against Acanthamoeba isolates.
score: 1.0796045, Antimicrobial agents and chemotherapy, 2002, Kilvington, Simon; Hughes, Reanne; Byas, James; Dart, John
Reemergence of macrolide resistance in pharyngeal isolates of group a streptococci in southwestern Pennsylvania.
score: 1.0796037, Antimicrobial agents and chemotherapy, 2004, Green, Michael et. al.
Antipneumococcal activities of GAR-936 (a new glycylcycline) compared to those of nine other agents against penicillin-susceptible and -resistant pneumococci.
score: 1.0795573, Antimicrobial agents and chemotherapy, 2000, Hoellman, D B; Pankuch, G A; Jacobs, M R; Appelbaum, P C
1H NMR studies of homo and mixed ligand complexes of Tl + ion with several polyazamacrocycles
score: 1.0795563, Bioorganic & Medicinal Chemistry, 2005, Bordbar, Maryam; Shamsipur, Mojtaba; Alizadeh, Naader
Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations.
score: 1.079418, Antimicrobial agents and chemotherapy, 1999, Martínez-Martínez, L et. al.
Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids.
score: 1.0794043, Antimicrobial agents and chemotherapy, 1999, Ochs, M M; McCusker, M P; Bains, M; Hancock, R E
Imipenem resistance in Salmonella enterica serovar Wien related to porin loss and CMY-4 beta-lactamase production.
score: 1.0793876, Antimicrobial agents and chemotherapy, 2003, Armand-Lefèvre, L et. al.
Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates.
score: 1.0793876, Antimicrobial agents and chemotherapy, 2010, Docquier, Jean-Denis et. al.
Combinatorial effect of two framework mutations (E119V and I222L) in the neuraminidase active site of H3N2 influenza virus on resistance to oseltamivir.
score: 1.0792948, Antimicrobial agents and chemotherapy, 2011, Richard, Mathilde et. al.
In vitro activities of ketolide HMR3647, macrolides, and other antibiotics against Lactobacillus, Leuconostoc, and Pediococcus isolates.
score: 1.0792816, Antimicrobial agents and chemotherapy, 1999, Zarazaga, M et. al.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
score: 1.0791626, Antimicrobial agents and chemotherapy, 2012, Tumbarello, Mario et. al.
Novel mechanism for fluoroquinolone resistance in Acinetobacter baumannii.
score: 1.0790414, Antimicrobial agents and chemotherapy, 2012, Saroj, Sunil D et. al.
Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives
score: 1.0789375, Bioorganic & Medicinal Chemistry, 2003, Cunha, Anna C. et. al.
Prediction of abacavir resistance from genotypic data: impact of zidovudine and lamivudine resistance in vitro and in vivo.
score: 1.0788708, Antimicrobial agents and chemotherapy, 2002, Walter, Hauke et. al.
Relationship between structure and permeability of dipeptide derivatives containing tryptophan and related compounds across human intestinal epithelial (Caco-2) cells
score: 1.0788191, Bioorganic & Medicinal Chemistry, 2004, Ano, Rieko et. al.
Chiral N-phosphonyl imine chemistry: Asymmetric synthesis of α,β-diamino esters by reacting phosphonyl imines with glycine enolates
score: 1.078772, Bioorganic & Medicinal Chemistry Letters, 2009, Ai, Teng; Li, Guigen
A cyclic phosphonamidate analogue of glucose as a selective inhibitor of inverting glycosidases
score: 1.0787456, Bioorganic & Medicinal Chemistry, 1996, Darrow, James W.; Drueckhammer, Dale G.
Once-daily amikacin dosing in burn patients treated with continuous venovenous hemofiltration.
score: 1.0787326, Antimicrobial agents and chemotherapy, 2011, Akers, Kevin S et. al.
Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker
score: 1.0787232, Bioorganic & Medicinal Chemistry, 2010, Aviñó, Anna et. al.
γ-glutamyl Spermine Synthetase PauA2 as a potential target of antibiotic development against Pseudomonas aeruginosa.
score: 1.0787157, Antimicrobial agents and chemotherapy, 2012, Yao, Xiangyu; Li, Congran; Zhang, Jianmei; Lu, Chung-Dar
Synthesis of benzimidazolyl–1,3,4–oxadiazol–2ylthio–N–phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents
score: 1.0787084, European Journal of Medicinal Chemistry, 2012, Patel, Rahul V. et. al.
Synthesis and characterization of novel 6-fluoro-4-piperidinyl-1,2-benzisoxazole amides and 6-fluoro-chroman-2-carboxamides: antimicrobial studies
score: 1.0786901, Bioorganic & Medicinal Chemistry, 2005, Priya, B.S. et. al.
Quinolones for treatment of human brucellosis: critical review of the evidence from microbiological and clinical studies.
score: 1.0786418, Antimicrobial agents and chemotherapy, 2006, Falagas, Matthew E; Bliziotis, Ioannis A
The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata.
score: 1.0786064, Antimicrobial agents and chemotherapy, 2012, Shields, Ryan K et. al.
Pharmacokinetics and pharmacodynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate.
score: 1.0785306, Antimicrobial agents and chemotherapy, 2002, Trampuz, Andrej et. al.
First Reported Case of Azole-Resistant Aspergillus fumigatus Due to the TR/L98H Mutation in Germany.
score: 1.0785159, Antimicrobial agents and chemotherapy, 2012, Rath, P-M et. al.
Improving the species cross-reactivity of an antibody using computational design
score: 1.0785058, Bioorganic & Medicinal Chemistry Letters, 2009, Farady, Christopher J. et. al.
Chemoenzymatic synthesis and antitumor promoting activity of 6′- and 3-esters of 2- O-β- d-glucosylglycerol
score: 1.078492, Bioorganic & Medicinal Chemistry, 1999, Colombo, Diego et. al.
Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents
score: 1.0784575, Bioorganic & Medicinal Chemistry, 2004, Takamura, Makoto et. al.
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis.
score: 1.0784498, Antimicrobial agents and chemotherapy, 2006, Chouchani, Chedly et. al.
Hydroxylamine analogs of 2,6 di- t-butylphenols: Dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors
score: 1.0783505, Bioorganic & Medicinal Chemistry, 1995, Kramer, James B. et. al.
Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime.
score: 1.0782987, Antimicrobial agents and chemotherapy, 2005, Alyaseen, Samer A et. al.
Treatment of experimental allergic encephalomyelitis (EAE) induced by guinea pig myelin basic protein epitope 72–85 with a Human MBP 87–99 analogue and effects of cyclic peptides
score: 1.0782882, Bioorganic & Medicinal Chemistry, 2000, Tselios, Theodore et. al.
Short- and long-term effects of pneumococcal conjugate vaccination of children on penicillin resistance.
score: 1.0782852, Antimicrobial agents and chemotherapy, 2004, Temime, L; Guillemot, D; Boëlle, P Y
Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance
score: 1.0782664, European Journal of Medicinal Chemistry, 2012, Uzgören-Baran, Ayşe et. al.
Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance
score: 1.0782664, European Journal of Medicinal Chemistry, 2012, Uzgören-Baran, Ayşe et. al.
Artemisinin antimalarials do not inhibit hemozoin formation.
score: 1.0781428, Antimicrobial agents and chemotherapy, 2003, Haynes, Richard K et. al.
A versatile strategy for the synthesis of crown ether-bearing heterocycles: Discovery of calcium-selective fluoroionophore
score: 1.078116, Bioorganic & Medicinal Chemistry, 2007, Aoki, Yuko et. al.
Effect of disruption of a gene encoding an autolysin of Enterococcus faecalis OG1RF.
score: 1.0781084, Antimicrobial agents and chemotherapy, 1998, Qin, X; Singh, K V; Xu, Y; Weinstock, G M; Murray, B E
Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia.
score: 1.0780354, Antimicrobial agents and chemotherapy, 1999, Lambert, T; Ploy, M C; Denis, F; Courvalin, P
Efficacy of a New Fluoroquinolone, JNJ-Q2, in Murine Models of Staphylococcus aureus and Streptococcus pneumoniae Skin, Respiratory, and Systemic Infections.
score: 1.0780078, Antimicrobial agents and chemotherapy, 2011, Fernandez, Jeffrey et. al.
Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy.
score: 1.0780008, Antimicrobial agents and chemotherapy, 2006, Coen, Muireann et. al.
Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms.
score: 1.0779705, Antimicrobial agents and chemotherapy, 2012, Neuner, Elizabeth A et. al.
Wake-promoting agents: Search for next generation modafinil: Part IV
score: 1.0779222, European Journal of Medicinal Chemistry, 2012, Louvet, Philippe et. al.
Wake-promoting agents: Search for next generation modafinil: Part IV
score: 1.0779222, European Journal of Medicinal Chemistry, 2012, Louvet, Philippe et. al.
Antioxidant action of sugar-pendant C 60 fullerenes
score: 1.0779209, Bioorganic & Medicinal Chemistry Letters, 2009, Horie, Masanori et. al.
Antibacterial effects of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae strains for which MICs are high, in an in vitro pharmacokinetic model.
score: 1.0778553, Antimicrobial agents and chemotherapy, 2004, MacGowan, Alasdair P et. al.
Evaluation of amphotericin B interpretive breakpoints for Candida bloodstream isolates by correlation with therapeutic outcome.
score: 1.0778446, Antimicrobial agents and chemotherapy, 2006, Park, Benjamin J et. al.
In vitro activity of tigecycline against Burkholderia pseudomallei and Burkholderia thailandensis.
score: 1.0778206, Antimicrobial agents and chemotherapy, 2006, Thamlikitkul, Visanu; Trakulsomboon, Suwanna
Ruthenium(II)–arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
score: 1.0776897, European Journal of Medicinal Chemistry, 2010, Grgurić-Šipka, Sanja et. al.
In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil.
score: 1.0776847, Antimicrobial agents and chemotherapy, 2008, Argenta, Juliana S et. al.
In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system.
score: 1.0776676, Antimicrobial agents and chemotherapy, 1999, Kita, H et. al.
Trichodiene synthase: Mechanism-based inhibition of a sesquiterpene cyclase
score: 1.0775848, Bioorganic & Medicinal Chemistry Letters, 1999, Cane, David E.; Bowser, Todd E.
Metalloporphyrin catalyzed oxidation of n-hydroxyguanidines: a biomimetic model for the H 2O 2-dependent activity of nitric oxide synthase
score: 1.077582, Bioorganic & Medicinal Chemistry Letters, 2000, Keserű, György M; Balogh, György T; Karancsi, Tamás
Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation.
score: 1.0775816, Antimicrobial agents and chemotherapy, 2005, Lomaestro, Ben M; Drusano, G L
Emergence of NDM-1 metallo-β-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia.
score: 1.077525, Antimicrobial agents and chemotherapy, 2011, Jovcic, Branko et. al.
Prospective observational study of the impact of VIM-1 metallo-beta-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections.
score: 1.0774633, Antimicrobial agents and chemotherapy, 2009, Daikos, George L et. al.
Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana
score: 1.0773914, Bioorganic & Medicinal Chemistry Letters, 2012, Lee, Jin Woo et. al.
Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide.
score: 1.0773457, Antimicrobial agents and chemotherapy, 1999, Kitaichi, K et. al.
Multiple-dose pharmacokinetics and pharmacodynamics of abacavir alone and in combination with zidovudine in human immunodeficiency virus-infected adults.
score: 1.0772904, Antimicrobial agents and chemotherapy, 2000, McDowell, J A; Lou, Y; Symonds, W S; Stein, D S
Synthesis and biological evaluation of l-α-Phosphatidyl- d-3-deoxy-3-heteromethyl- myo-inositols as phosphoinositide 3-kinase inhibitors
score: 1.07729, Bioorganic & Medicinal Chemistry, 2001, Wang, Da-Sheng; Chen, Ching-Shih
Control of leakage activities of alamethicin analogs by metals: Side chain-dependent adverse gating response to Zn2+
score: 1.0772017, Bioorganic & Medicinal Chemistry, 2012, Noshiro, Daisuke; Asami, Koji; Futaki, Shiroh
In vitro and in vivo efficacies of T-3811ME (BMS-284756) against Mycoplasma pneumoniae.
score: 1.0771212, Antimicrobial agents and chemotherapy, 2001, Takahata, M et. al.
Molecular and epidemiological evidence for spread of multiresistant methicillin-susceptible Staphylococcus aureus strains in hospitals.
score: 1.077007, Antimicrobial agents and chemotherapy, 2007, Donnio, Pierre-Yves et. al.
Effects of structural modification on the DNA binding properties and photo-induced cleavage reactivity of propargylic sulfones conjugated with an anthraquinone structure
score: 1.0769481, Bioorganic & Medicinal Chemistry, 2006, Haruna, Ken-ichi et. al.
Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase.
score: 1.0768934, Antimicrobial agents and chemotherapy, 2002, Vessillier, Sandrine et. al.
Electrochemical and esr spin trap studies of a new iron tetra- catecholamide complex
score: 1.0768592, Bioorganic & Medicinal Chemistry Letters, 1999, Cheraïti, N.; Brik, M.E.; Keita, B.; Nadjo, L.; Gaudemer, A.
Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis.
score: 1.0768488, Antimicrobial agents and chemotherapy, 2005, Kutlin, Andrei et. al.
At the crossroads of chemistry and biology
score: 1.076769, Bioorganic & Medicinal Chemistry, 2003, Waldmann, H
Visceral leishmaniasis in the BALB/c mouse: a comparison of the efficacy of a nonionic surfactant formulation of sodium stibogluconate with those of three proprietary formulations of amphotericin B.
score: 1.076765, Antimicrobial agents and chemotherapy, 1998, Mullen, A B; Baillie, A J; Carter, K C
Novel streptomycin resistance gene from Mycobacterium fortuitum.
score: 1.0767404, Antimicrobial agents and chemotherapy, 2006, Ramón-García, Santiago et. al.
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.
score: 1.0766914, Antimicrobial agents and chemotherapy, 2002, Boyd, D A; Cabral, T; Van Caeseele, P; Wylie, J; Mulvey, M R
Evidence of antibiotic resistance gene silencing in Escherichia coli.
score: 1.0766882, Antimicrobial agents and chemotherapy, 2006, Enne, Virve I; Delsol, Anne A; Roe, John M; Bennett, Peter M
Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.
score: 1.0766821, Antimicrobial agents and chemotherapy, 2008, Ostrosky-Zeichner, Luis et. al.
Sweet spots in functional glycomics.
score: 1.0766591, Nature chemical biology, 2006, Paulson, James C; Blixt, Ola; Collins, Brian E
Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.
score: 1.0766101, Antimicrobial agents and chemotherapy, 2004, Fillet, Anne-Marie et. al.
A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates.
score: 1.076473, Antimicrobial agents and chemotherapy, 2000, Landry, M L et. al.
Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green.
score: 1.0764115, Antimicrobial agents and chemotherapy, 2009, Banaei, Niaz et. al.
Synthesis of a fluorine-18 labeled derivative of epibatidine for in vivo nicotinic acetylcholine receptor PET imaging
score: 1.076409, Bioorganic & Medicinal Chemistry, 1999, Dolci, Lilian et. al.
Effect of differences in MIC values on clinical outcomes in patients with bloodstream infections caused by gram-negative organisms treated with levofloxacin.
score: 1.0763813, Antimicrobial agents and chemotherapy, 2009, Defife, Robyn et. al.
In vitro and in vivo intracellular killing effects of tigecycline against clinical nontyphoid Salmonella isolates using ceftriaxone as a comparator.
score: 1.0763353, Antimicrobial agents and chemotherapy, 2011, Tang, Hung-Jen et. al.
Effect of cell culture conditions on the anticytomegalovirus activity of maribavir.
score: 1.0762513, Antimicrobial agents and chemotherapy, 2006, Chou, Sunwen; Van Wechel, Laura C; Marousek, Gail I
Bio-inspired synthetic receptor molecules towards mimicry of vancomycin
score: 1.0761971, Bioorganic & Medicinal Chemistry Letters, 2001, Monnee, Menno C.F et. al.
Susceptibilities to levofloxacin in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children: results from 2000-2001 and 2001-2002 TRUST studies in the United States.
score: 1.0761958, Antimicrobial agents and chemotherapy, 2003, Karlowsky, James A et. al.
Design of new β 1-selective adrenoceptor ligands as potential radioligands for in vivo imaging
score: 1.0761552, Bioorganic & Medicinal Chemistry, 2003, Kopka, Klaus et. al.
Full and Broad-Spectrum In Vivo Eradication of Catheter-Associated Biofilms Using Gentamicin-EDTA Antibiotic Lock Therapy.
score: 1.0761128, Antimicrobial agents and chemotherapy, 2012, Chauhan, Ashwini et. al.
QSAR analysis of phenolic antioxidants using MOLMAP descriptors of local properties
score: 1.0761097, Bioorganic & Medicinal Chemistry, 2006, Gupta, Sunil et. al.
PBP 2a mutations producing very-high-level resistance to beta-lactams.
score: 1.0760811, Antimicrobial agents and chemotherapy, 2004, Katayama, Yuki; Zhang, Hong-Zhong; Chambers, Henry F
Synergistic effect of clindamycin and atovaquone in acute murine toxoplasmosis.
score: 1.075994, Antimicrobial agents and chemotherapy, 1999, Djurković-Djaković, O et. al.
In vitro pharmacodynamic characteristics of amphotericin B, caspofungin, fluconazole, and voriconazole against bloodstream isolates of infrequent Candida species from patients with hematologic malignancies.
score: 1.0759738, Antimicrobial agents and chemotherapy, 2004, Di Bonaventura, Giovanni et. al.
First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.
score: 1.0759222, Antimicrobial agents and chemotherapy, 2005, Lolans, K; Queenan, A M; Bush, K; Sahud, A; Quinn, J P
Comparison of Genospecies and Antimicrobial Resistance Profiles of Isolates in the Acinetobacter calcoaceticus-Acinetobacter baumannii Complex from Various Clinical Specimens.
score: 1.0759039, Antimicrobial agents and chemotherapy, 2012, Tien, Ni et. al.
Binding studies of cationic uridyl ribonucleic guanidine (RNG) to DNA
score: 1.0757917, Bioorganic & Medicinal Chemistry Letters, 2005, Park, Myunji; Bruice, Thomas C.
Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.
score: 1.0756016, Antimicrobial agents and chemotherapy, 2004, Markovich, Sarit et. al.
Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.
score: 1.0755519, Antimicrobial agents and chemotherapy, 2002, Schaller, Alain et. al.
Probe design and synthesis of Galβ(1→3)[NeuAcα(2→6)]GlcNAcβ(1→2)Man motif of N-glycan
score: 1.0755398, Bioorganic & Medicinal Chemistry, 2010, Bao, Guang-ming et. al.
Lipase-catalysed regio- and enantioselective deacetylation of 2,4-diacetoxyphenyl alkyl ketones
score: 1.0755, Bioorganic & Medicinal Chemistry, 1999, Prasad, Ashok K. et. al.
Combination Therapy with Ampicillin and Daptomycin for Treatment of Enterococcus faecalis Endocarditis.
score: 1.075485, Antimicrobial agents and chemotherapy, 2012, Sierra-Hoffman, M; Iznaola, O; Goodwin, M; Mohr, J
In vitro activities of SCH27899 alone and in combination with 17 other antimicrobial agents.
score: 1.075466, Antimicrobial agents and chemotherapy, 1999, Fuchs, P C; Barry, A L; Brown, S D
Xanthones as inhibitors of growth of human cancer cell lines and Their effects on the proliferation of human lymphocytes In Vitro
score: 1.0754632, Bioorganic & Medicinal Chemistry, 2002, Pedro, Madalena et. al.
Synthesis and biological evaluation of potent glycosidase inhibitors: N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino- C-(hydroxymethyl)-1,2,3,4-cyclopentanetetraols
score: 1.07543, Bioorganic & Medicinal Chemistry, 1997, Uchida, Chikara; Kimura, Hiroshi; Ogawa, Seiichiro
Oligonucleotides containing a new type of acyclic, achiral nucleoside analogue: 1-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]thymine
score: 1.0754194, Bioorganic & Medicinal Chemistry Letters, 2003, Boesen, Thomas et. al.
UC781 microbicide gel retains anti-HIV activity in cervicovaginal lavage fluids collected following twice-daily vaginal application.
score: 1.0753859, Antimicrobial agents and chemotherapy, 2012, Haaland, Richard E et. al.
Human serum albumin interaction with formononetin studied using fluorescence anisotropy, FT-IR spectroscopy, and molecular modeling methods
score: 1.0753817, Bioorganic & Medicinal Chemistry, 2006, Li, Ying et. al.
Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids
score: 1.0753705, European Journal of Medicinal Chemistry, 2004, N'Goka, Victor et. al.
New insights into protein crosslinking via the Maillard reaction: structural requirements, the effect on enzyme function, and predicted efficacy of crosslinking inhibitors as anti-ageing therapeutics
score: 1.0753307, Bioorganic & Medicinal Chemistry, 2003, Miller, Antonia G; Meade, Susie J; Gerrard, Juliet A
Lack of evidence for involvement of hypermutability in emergence of vancomycin-intermediate Staphylococcus aureus.
score: 1.0752825, Antimicrobial agents and chemotherapy, 2003, O'Neill, Alexander J; Chopra, Ian
Correlation between E-test, disk diffusion, and microdilution methods for antifungal susceptibility testing of fluconazole and voriconazole.
score: 1.0752784, Antimicrobial agents and chemotherapy, 2003, Matar, Madonna J et. al.
Efficacy of trovafloxacin against experimental Staphylococcus aureus endocarditis.
score: 1.0752493, Antimicrobial agents and chemotherapy, 1998, Kaatz, G W et. al.
Effect of sucralfate on antibiotic therapy for Helicobacter pylori infection in mice.
score: 1.0752442, Antimicrobial agents and chemotherapy, 2004, Watanabe, Koichiro et. al.
Natural products in crop protection
score: 1.0752369, Bioorganic & Medicinal Chemistry, 2009, Dayan, Franck E.; Cantrell, Charles L.; Duke, Stephen O.
Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.
score: 1.0752343, Antimicrobial agents and chemotherapy, 2003, Mann, Paul A et. al.
Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype.
score: 1.0751917, Antimicrobial agents and chemotherapy, 2011, Ramirez, Maria Soledad et. al.
Sesquiterpene lactones as inhibitors of human neutrophil elastase
score: 1.075118, Bioorganic & Medicinal Chemistry, 2002, Siedle, B et. al.
In vitro and in vivo antibacterial activities of DK-507k, a novel fluoroquinolone.
score: 1.0750775, Antimicrobial agents and chemotherapy, 2003, Otani, Tsuyoshi et. al.
Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial: the MACH 2 study.
score: 1.0750243, Antimicrobial agents and chemotherapy, 1999, Mégraud, F et. al.
Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.
score: 1.0750144, Antimicrobial agents and chemotherapy, 2001, Schöler, N et. al.
Identification of a novel variant of staphylococcal cassette chromosome mec, type II.5, and Its truncated form by insertion of putative conjugative transposon Tn6012.
score: 1.0750138, Antimicrobial agents and chemotherapy, 2009, Han, Xiao et. al.
Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase.
score: 1.0747849, Antimicrobial agents and chemotherapy, 2008, Hanes, Jeremiah W; Johnson, Kenneth A
Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains.
score: 1.0746758, Antimicrobial agents and chemotherapy, 2003, Loeffler, J M; Fischetti, V A
Deletions of the endocytic components VPS28 and VPS32 in Candida albicans lead to echinocandin and azole hypersensitivity.
score: 1.0745187, Antimicrobial agents and chemotherapy, 2006, Cornet, Muriel; Gaillardin, Claude; Richard, Mathias L
Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene.
score: 1.0744987, Antimicrobial agents and chemotherapy, 2012, Kapoor, Arun et. al.
Synthesis and biodistribution of [ 11C]R116301, a promising PET ligand for central NK 1 receptors
score: 1.0744709, Bioorganic & Medicinal Chemistry, 2005, Van der Mey, M. et. al.
Sophorolipids having enhanced antibacterial activity.
score: 1.0744546, Antimicrobial agents and chemotherapy, 2007, Shah, Vishal; Badia, Daniel; Ratsep, Peter
IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain.
score: 1.074443, Antimicrobial agents and chemotherapy, 2000, Giakkoupi, P et. al.
Studies on self-aggregation of anthracycline drugs by restrained molecular dynamics approach using nuclear magnetic resonance spectroscopy supported by absorption, fluorescence, diffusion ordered spectroscopy and mass spectrometry
score: 1.0744395, European Journal of Medicinal Chemistry, 2009, Agrawal, Prashansa; Barthwal, Sudhir Kumar; Barthwal, Ritu
Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex.
score: 1.0744358, Antimicrobial agents and chemotherapy, 2011, Projahn, Michaela et. al.
New mutation in parE in a pneumococcal in vitro mutant resistant to fluoroquinolones.
score: 1.0744121, Antimicrobial agents and chemotherapy, 2001, Janoir, C; Varon, E; Kitzis, M D; Gutmann, L
Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine
score: 1.0743893, Bioorganic & Medicinal Chemistry, 2002, Brahic, Christine et. al.
Synthesis and properties of bifunctional chloroalkyl nitrosamines with an intercalating moiety
score: 1.0743298, Bioorganic & Medicinal Chemistry, 2004, Ishikawa, Satoko; Tajima, Megumi; Mochizuki, Masataka
Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays.
score: 1.0743022, Antimicrobial agents and chemotherapy, 2001, Wu, P; Lawrence, L E; Denbleyker, K L; Barrett, J F
Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG.
score: 1.0742925, Antimicrobial agents and chemotherapy, 2012, Ramón-García, Santiago et. al.
In vitro susceptibilities of Malassezia species to a new triazole, albaconazole (UR-9825), and other antifungal compounds.
score: 1.0742852, Antimicrobial agents and chemotherapy, 2003, Garau, Margarita; Pereiro, Manolo; del Palacio, Amalia
Insight into the strong inhibitory action of salt on activity of neocarzinostatin
score: 1.074256, Bioorganic & Medicinal Chemistry, 2010, Chin, Der-Hang et. al.
Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to beta-lactams.
score: 1.0742501, Antimicrobial agents and chemotherapy, 2003, Mammeri, Hedi et. al.
Mutant A1555G mitochondrial 12S rRNA and aminoglycoside susceptibility.
score: 1.0742455, Antimicrobial agents and chemotherapy, 2010, Böttger, Erik C
1 Hit and Lead Identification: Efficient Practices for Drug Discovery
score: 1.0742414, Progress in Medicinal Chemistry, 2007, Goodnow, Robert; Gillespie, Paul
Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae.
score: 1.0742191, Antimicrobial agents and chemotherapy, 2001, Depardieu, F; Courvalin, P
Design and synthesis of 3-phenyl tetrahydronaphthalenic derivatives as new selective MT 2 melatoninergic ligands
score: 1.0741454, Bioorganic & Medicinal Chemistry, 2003, Yous, Saı̈d et. al.
Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.
score: 1.0741258, Antimicrobial agents and chemotherapy, 2003, Wei, Chih-Jen; Lei, Benfang; Musser, James M; Tu, Shiao-Chun
Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome.
score: 1.0740431, Antimicrobial agents and chemotherapy, 2005, Kartsonis, Nicholas et. al.
Carbohydrate mimetics-based glycosyltransferase inhibitors
score: 1.0740331, Bioorganic & Medicinal Chemistry, 2001, Compain, Philippe; Martin, Olivier R.
Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase β
score: 1.0739708, Bioorganic & Medicinal Chemistry, 2000, Deng, Jing-Zhen; Starck, Shelley R.; Hecht, Sidney M.
Change in colony morphology of Candida lusitaniae in association with development of amphotericin B resistance.
score: 1.0739401, Antimicrobial agents and chemotherapy, 2002, McClenny, Nancy B et. al.
Synthesis and cytotoxicities of mannose conjugated S-Nitroso- N-acetylpenicillamine (SNAP)
score: 1.0738759, Bioorganic & Medicinal Chemistry, 2002, Wu, Xuejun et. al.
Penetration of linezolid into the anterior chamber (aqueous humor) of the human eye after intravenous administration.
score: 1.0738646, Antimicrobial agents and chemotherapy, 2004, Vázquez, E García et. al.
Covalent modification of subtilisin Bacillus lentus Cysteine mutants with enantiomerically pure chiral auxiliaries causes remarkable changes in activity
score: 1.0737978, Bioorganic & Medicinal Chemistry, 2000, Dickman, Michael; Jones, J.Bryan
Comparative in vitro activities of ertapenem (MK-0826) against 469 less frequently identified anaerobes isolated from human infections.
score: 1.0737704, Antimicrobial agents and chemotherapy, 2002, Goldstein, Ellie J C et. al.
Oral delivery of meglumine antimoniate-beta-cyclodextrin complex for treatment of leishmaniasis.
score: 1.0737531, Antimicrobial agents and chemotherapy, 2004, Demicheli, Cynthia et. al.
In vitro activities of ertapenem (MK-0826) against recent clinical bacteria collected in Europe and Australia.
score: 1.0737522, Antimicrobial agents and chemotherapy, 2001, Livermore, D M et. al.
Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils.
score: 1.0736558, Antimicrobial agents and chemotherapy, 1998, Turner, J; Cho, Y; Dinh, N N; Waring, A J; Lehrer, R I
PEGylated iminodiacetic acid zinc complex stabilizes cationic RNA-bearing nanoparticles
score: 1.0736121, Bioorganic & Medicinal Chemistry Letters, 2010, Levy, Daniel E.; Ding, Zhongli; Hu, Chiwei; Zalipsky, Samuel
Lamivudine can exert a modest antiviral effect against human immunodeficiency virus type 1 containing the M184V mutation.
score: 1.0735549, Antimicrobial agents and chemotherapy, 2003, Quan, Yudong et. al.
Antifungal activity of 3'-deoxyadenosine (cordycepin).
score: 1.073547, Antimicrobial agents and chemotherapy, 1998, Sugar, A M; McCaffrey, R P
Efficacy of linezolid plus rifampin in an experimental model of methicillin-susceptible Staphylococcus aureus endocarditis.
score: 1.0735178, Antimicrobial agents and chemotherapy, 2003, Dailey, Charlene F et. al.
Efflux pump overexpression in multiple-antibiotic-resistant mutants of Bacteroides fragilis.
score: 1.0734712, Antimicrobial agents and chemotherapy, 2006, Pumbwe, Lilian; Glass, Daniel; Wexler, Hannah M
Extended-spectrum beta-lactamase TEM-24 in an Aeromonas clinical strain: acquisition from the prevalent Enterobacter aerogenes clone in France.
score: 1.073413, Antimicrobial agents and chemotherapy, 2003, Marchandin, H et. al.
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
score: 1.0734111, Antimicrobial agents and chemotherapy, 2004, Steinbach, William J et. al.
Alterations in topoisomerase IV and DNA gyrase in quinolone-resistant mutants of Mycoplasma hominis obtained in vitro.
score: 1.0733794, Antimicrobial agents and chemotherapy, 1998, Bébéar, C M et. al.
Plasmid-mediated coresistance to streptogramins and vancomycin in Enterococcus faecium HM1032.
score: 1.073342, Antimicrobial agents and chemotherapy, 1999, Bozdogan, B; Leclercq, R; Lozniewski, A; Weber, M
Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1
score: 1.0733287, Bioorganic & Medicinal Chemistry, 2012, Johnston, Jonathan B. et. al.
Inhibition of platelet adhesion by peptidomimetics mimicking the interactive β-hairpin of glycoprotein Ibα
score: 1.0732863, Bioorganic & Medicinal Chemistry Letters, 2012, Bernard, Elise et. al.
Inhibition of platelet adhesion by peptidomimetics mimicking the interactive β-hairpin of glycoprotein Ibα
score: 1.0732863, Bioorganic & Medicinal Chemistry Letters, 2012, Bernard, Elise et. al.
Inhibition of platelet adhesion by peptidomimetics mimicking the interactive β-hairpin of glycoprotein Ibα
score: 1.0732863, Bioorganic & Medicinal Chemistry Letters, 2012, Bernard, Elise et. al.
New susceptibility breakpoints and the regional variability of MIC distribution in Mycobacterium tuberculosis isolates.
score: 1.0732688, Antimicrobial agents and chemotherapy, 2012, Pasipanodya, Jotam; Srivastava, Shashikant; Gumbo, Tawanda
Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents.
score: 1.073267, Antimicrobial agents and chemotherapy, 2006, Coelho, Juliana et. al.
First isolation of a CTX-M-3-producing Enterobacter cloacae in France.
score: 1.0732636, Antimicrobial agents and chemotherapy, 2000, Doucet-Populaire, F; Ghnassia, J C; Bonnet, R; Sirot, J
Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents
score: 1.0732424, European Journal of Medicinal Chemistry, 2012, Patel, Rahul V. et. al.
Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC. A simple model for predicting blood–brain distribution
score: 1.0732329, European Journal of Medicinal Chemistry, 2003, Gulyaeva, Nellie et. al.
Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase
score: 1.073174, Bioorganic & Medicinal Chemistry, 2005, Kumar, Ajit et. al.
Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin.
score: 1.0731582, Antimicrobial agents and chemotherapy, 2003, Anderl, Jeff N; Zahller, Jeff; Roe, Frank; Stewart, Philip S
Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5]benzothiazepines as potential antimicrobial agents
score: 1.0731385, European Journal of Medicinal Chemistry, 2012, Mor, Satbir; Pahal, Preeti; Narasimhan, Balasubramanian
Bactericidal potencies of new regimens are not predictive of their sterilizing potencies in a murine model of tuberculosis.
score: 1.0731146, Antimicrobial agents and chemotherapy, 2010, Andries, Koen; Gevers, Tom; Lounis, Nacer
A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.
score: 1.0730053, Antimicrobial agents and chemotherapy, 2006, Novotna, G; Janata, J
Synthesis, biodistribution and antitumor activity of hematoporphyrin–platinum(II) conjugates
score: 1.0729067, Bioorganic & Medicinal Chemistry, 2003, Kim, Yeong-Sang et. al.
Macrolide susceptibility and beta-lactamase production among haemophilus influenzae isolates in the United States, 1996-1997.
score: 1.0729066, Antimicrobial agents and chemotherapy, 1998, Hogan, P A; Sheehan, D J
Pharmacodynamics of β-Lactamase Inhibition by NXL104 in Combination with Ceftaroline: Examining Organisms with Multiple Types of β-Lactamases.
score: 1.0728781, Antimicrobial agents and chemotherapy, 2012, Louie, Arnold et. al.
Postneurosurgical meningitis due to Proteus penneri with selection of a ceftriaxone-resistant isolate: analysis of chromosomal class A beta-lactamase HugA and its LysR-type regulatory protein HugR.
score: 1.0728222, Antimicrobial agents and chemotherapy, 2002, Liassine, Nadia et. al.
A small subpopulation of blastospores in candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and beta-1,6-glucan pathway genes.
score: 1.0728093, Antimicrobial agents and chemotherapy, 2006, Khot, Prasanna D et. al.
ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.
score: 1.0727958, Antimicrobial agents and chemotherapy, 2010, Hentschke, M et. al.
In vitro activities of anidulafungin and other antifungal agents against biofilms formed by clinical isolates of different Candida and Aspergillus species.
score: 1.0727834, Antimicrobial agents and chemotherapy, 2011, Fiori, Barbara et. al.
Nonisotopic, semiautomated plasmodium falciparum bioassay for measurement of antimalarial drug levels in serum or plasma.
score: 1.0727787, Antimicrobial agents and chemotherapy, 2004, Noedl, Harald et. al.
Microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community-acquired pneumonia.
score: 1.0727676, Antimicrobial agents and chemotherapy, 1998, Roblin, P M; Hammerschlag, M R
Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine
score: 1.0727148, Bioorganic & Medicinal Chemistry, 2008, Chen, Shengxi; Hecht, Sidney M.
Cytotoxicity and effects of 1,10-phenanthroline and 5-amino-1,10-phenanthroline derivatives on some immunocompetent cells
score: 1.0726787, European Journal of Medicinal Chemistry, 2009, Wesselinova, Diana; Kaloyanov, Nikolay; Dimitrov, Georgi
RNA–DNA Hybrids Containing Damaged DNA are Substrates for RNase H
score: 1.0726767, Bioorganic & Medicinal Chemistry Letters, 2001, Shiels, Jerome C et. al.
Determination of tissue penetration and pharmacokinetics of linezolid in patients with diabetic foot infections using in vivo microdialysis.
score: 1.0726384, Antimicrobial agents and chemotherapy, 2011, Wiskirchen, Dora E et. al.
Crystal structure of an intermolecular 2:1 complex between adenine and thymine. Evidence for both Hoogsteen and ‘quasi-Watson–Crick’ interactions
score: 1.0726222, Bioorganic & Medicinal Chemistry Letters, 2010, Chandrasekhar, Sosale et. al.
Dinucleotide analogues as novel inhibitors of RNA-dependent RNA polymerase of hepatitis C Virus.
score: 1.0725739, Antimicrobial agents and chemotherapy, 2003, Zhong, Weidong; An, Haoyun; Barawkar, Dinesh; Hong, Zhi
Streptococcus pyogenes YtgP (Spy_0390) complements Escherichia coli strains depleted of the putative peptidoglycan flippase MurJ.
score: 1.0725691, Antimicrobial agents and chemotherapy, 2009, Ruiz, Natividad
A 9- cis-epoxycarotenoid dioxygenase inhibitor for use in the elucidation of abscisic acid action mechanisms
score: 1.0725504, Bioorganic & Medicinal Chemistry, 2006, Kitahata, Nobutaka et. al.
Ribokinase from E. coli: Expression, purification, and substrate specificity
score: 1.072463, Bioorganic & Medicinal Chemistry, 2006, Chuvikovsky, Dmitry V. et. al.
Genetic Markers of Widespread Extensively Drug-Resistant Pseudomonas aeruginosa High-Risk Clones.
score: 1.072427, Antimicrobial agents and chemotherapy, 2012, Cabot, Gabriel et. al.
Comparative efficacies of antibiotics in a rat model of meningoencephalitis due to Listeria monocytogenes.
score: 1.0723909, Antimicrobial agents and chemotherapy, 1999, Michelet, C; Leib, S L; Bentue-Ferrer, D; Täuber, M G
Synthesis and in vitro cytotoxicity of haloderivatives of noscapine
score: 1.0723534, Bioorganic & Medicinal Chemistry, 2006, Verma, Akhilesh Kumar et. al.
Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.
score: 1.0722748, Antimicrobial agents and chemotherapy, 2004, Kern, Earl R et. al.
vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174.
score: 1.0722658, Antimicrobial agents and chemotherapy, 2000, Arias, C A; Courvalin, P; Reynolds, P E
Synthesis of phosphorothioate oligonucleotide–peptide conjugates by solid phase fragment condensation
score: 1.072255, Bioorganic & Medicinal Chemistry Letters, 2007, Diala, Irmina et. al.
Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori.
score: 1.0722196, Antimicrobial agents and chemotherapy, 1999, Wang, G; Rahman, M S; Humayun, M Z; Taylor, D E
First extended-spectrum-beta-lactamase (CTX-M-15)-producing Salmonella enterica serotype typhimurium isolate identified in Lebanon.
score: 1.0722196, Antimicrobial agents and chemotherapy, 2005, Moubareck, C et. al.
Cytotoxic T lymphocyte epitope analogues containing cis- or trans-4-aminocyclohexanecarboxylic acid residues
score: 1.0721945, Bioorganic & Medicinal Chemistry, 2002, Marastoni, Mauro et. al.
Efficacy of liposomal amphotericin B in treatment of systemic murine fusariosis.
score: 1.0721746, Antimicrobial agents and chemotherapy, 2002, Ortoneda, Montserrat et. al.
Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain.
score: 1.0721619, Antimicrobial agents and chemotherapy, 2004, Chen, Yahua; Tenover, Fred C; Koehler, Theresa M
In vitro antifungal activities of the new triazole UR-9825 against clinically important filamentous fungi.
score: 1.0721255, Antimicrobial agents and chemotherapy, 2001, Capilla, J; Ortoneda, M; Pastor, F J; Guarro, J
Comparison of in vitro activity of liposomal nystatin against Aspergillus species with those of nystatin, amphotericin B (AB) deoxycholate, AB colloidal dispersion, liposomal AB, AB lipid complex, and itraconazole.
score: 1.0720178, Antimicrobial agents and chemotherapy, 1999, Oakley, K L; Moore, C B; Denning, D W
QSPR models for polychlorinated biphenyls: n-Octanol/water partition coefficient
score: 1.0720061, Bioorganic & Medicinal Chemistry, 2006, Padmanabhan, J. et. al.
Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[ N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives
score: 1.0720043, European Journal of Medicinal Chemistry, 2005, Turan-Zitouni, Gülhan et. al.
Nosocomial outbreak of extended-spectrum beta-lactamase SHV-5-producing isolates of Pseudomonas aeruginosa in Athens, Greece.
score: 1.0720027, Antimicrobial agents and chemotherapy, 2004, Poirel, Laurent et. al.
Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile
score: 1.0719995, Bioorganic & Medicinal Chemistry, 2005, Ziakas, George N. et. al.
Lack of pharmacokinetic drug interaction between tenofovir disoproxil fumarate and nelfinavir mesylate.
score: 1.0718965, Antimicrobial agents and chemotherapy, 2005, Boffito, Marta et. al.
Emergence of multidrug-resistant Klebsiella pneumoniae isolates producing VIM-4 metallo-beta-lactamase, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC beta-lactamase in a Tunisian university hospital.
score: 1.0718273, Antimicrobial agents and chemotherapy, 2006, Ktari, Sonia et. al.
Differential Aspergillus lentulus echinocandin susceptibilities are Fksp independent.
score: 1.0718192, Antimicrobial agents and chemotherapy, 2010, Staab, Janet F; Kahn, Jennifer Nielsen; Marr, Kieren A
New synthetic siderophores and Their β-Lactam conjugates based on diamino acids and dipeptides
score: 1.0717928, Bioorganic & Medicinal Chemistry, 2002, Wittmann, S et. al.
A highly selective Hsp90 affinity chromatography resin with a cleavable linker
score: 1.0717877, Bioorganic & Medicinal Chemistry, 2012, Hughes, Philip F. et. al.
A highly selective Hsp90 affinity chromatography resin with a cleavable linker
score: 1.0717877, Bioorganic & Medicinal Chemistry, 2012, Hughes, Philip F. et. al.
Pyrrolo[2,1- c][1,2,4]triazines from 2-diazopyrroles: synthesis and antiproliferative activity
score: 1.0717843, European Journal of Medicinal Chemistry, 2002, Diana, Patrizia et. al.
New reagents for phosphatidylserine recognition and detection of apoptosis
score: 1.0717352, Bioorganic & Medicinal Chemistry, 2005, Hanshaw, Roger G.; Smith, Bradley D.
Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates.
score: 1.0717059, Antimicrobial agents and chemotherapy, 2005, Webber, Mark A; Talukder, Ashraf; Piddock, Laura J V
Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3.
score: 1.0716767, Antimicrobial agents and chemotherapy, 2008, Hinrichsen, Kerstin et. al.
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.
score: 1.071671, Antimicrobial agents and chemotherapy, 2005, Guardabassi, Luca et. al.
Molecular recognition by acetylcholinesterase at the peripheral anionic site: structure–activity relationships for inhibitions by aryl carbamates
score: 1.0716021, Bioorganic & Medicinal Chemistry, 1999, Lin, Gialih; Lai, Cheng-Yue; Liao, Wei-Cheng
Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A.
score: 1.071554, Antimicrobial agents and chemotherapy, 2005, Baum, Ellen Z et. al.
Assessing the in vitro effectiveness of antimicrobials against Mycoplasma mycoides subsp. mycoides small-colony type to reduce contagious bovine pleuropneumonia infection.
score: 1.071546, Antimicrobial agents and chemotherapy, 2005, Ayling, R D et. al.
Local variants of Staphylococcal cassette chromosome mec in sporadic methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococci: evidence of horizontal gene transfer?
score: 1.0715345, Antimicrobial agents and chemotherapy, 2004, Hanssen, Anne-Merethe et. al.
Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing.
score: 1.0715336, Antimicrobial agents and chemotherapy, 2005, Pettit, Robin K et. al.
Carboproteins: A 4-α-helix bundle protein model assembled on a d-galactopyranoside template
score: 1.0715051, Bioorganic & Medicinal Chemistry Letters, 2001, Brask, Jesper; Jensen, Knud J
Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis.
score: 1.0715042, Antimicrobial agents and chemotherapy, 2009, Serrano-Martín, Xenón et. al.
Effect of posaconazole on cyclosporine blood levels and dose adjustment in allogeneic blood and marrow transplant recipients.
score: 1.0714773, Antimicrobial agents and chemotherapy, 2012, Sánchez-Ortega, Isabel et. al.
Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii.
score: 1.0714443, Antimicrobial agents and chemotherapy, 2007, Corvec, Stéphane et. al.
Synthesis and biological evaluation of cyclopenta[ c]thiophene related compounds as new antitumor agents
score: 1.0714426, Bioorganic & Medicinal Chemistry, 2002, Dallemagne, Patrick et. al.
In vitro activity of cefpodoxime, an expanded-spectrum cephalosporin, against Salmonella enterica serotype typhi.
score: 1.0714377, Antimicrobial agents and chemotherapy, 2008, Sen, Bhaswati; Bhattacharya, Manjira; Niyogi, Swapan K
Effects of AIDS and gender on steady-state plasma and intrapulmonary ethionamide concentrations.
score: 1.0714072, Antimicrobial agents and chemotherapy, 2000, Conte, J E et. al.
The influence of modified purine bases on the stability of parallel DNA
score: 1.0712809, Bioorganic & Medicinal Chemistry Letters, 2000, Seela, Frank et. al.
A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V.
score: 1.0712717, Antimicrobial agents and chemotherapy, 2000, Hertogs, K et. al.
Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate
score: 1.0712054, Bioorganic & Medicinal Chemistry, 2012, Poreddy, Amruta R. et. al.
Molecular complexity from aromatics: Synthesis and photoreaction of endo-tricyclo[5.2.2.0 2,6]undecane—A stereoselective route to tricyclic framework of protoilludanes
score: 1.0711688, Bioorganic & Medicinal Chemistry Letters, 2005, Singh, Vishwakarma; Lahiri, Sanjoy; Pal, Shantanu
Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition.
score: 1.0711095, Antimicrobial agents and chemotherapy, 2008, Fransen, Signe et. al.
Synthesis and pharmacological activities of some mononuclear Ru(II) complexes
score: 1.0711029, Bioorganic & Medicinal Chemistry, 2005, Mazumder, Upal K. et. al.
In vitro susceptibilities of rapidly growing mycobacteria to telithromycin (HMR 3647) and seven other antimicrobials.
score: 1.0710746, Antimicrobial agents and chemotherapy, 2000, Fernández-Roblas, R et. al.
Synthesis and evaluation of novel chromogenic aminopeptidase substrates for microorganism detection and identification
score: 1.0710112, Bioorganic & Medicinal Chemistry Letters, 2007, James, Arthur L. et. al.
Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques
score: 1.0709938, European Journal of Medicinal Chemistry, 2004, Sato, Kumi et. al.
( R, Z)-7,15-Hexadecadien-4-olide, sex pheromone of the yellowish elongate chafer, Heptophylla picea
score: 1.0709936, Bioorganic & Medicinal Chemistry, 1996, Leal, Walter Soares et. al.
Use of pharmacokinetic and pharmacodynamic principles to determine optimal administration of daptomycin in patients receiving standardized thrice-weekly hemodialysis.
score: 1.0709678, Antimicrobial agents and chemotherapy, 2011, Patel, Nimish et. al.
Macrolide-resistant Streptococcus pyogenes in Norway: population structure and resistance determinants.
score: 1.0708751, Antimicrobial agents and chemotherapy, 2006, Littauer, P et. al.
First outbreak of Klebsiella pneumoniae clinical isolates producing GES-5 and SHV-12 extended-spectrum beta-lactamases in Korea.
score: 1.0708751, Antimicrobial agents and chemotherapy, 2005, Jeong, Seok Hoon et. al.
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles
score: 1.0708042, Bioorganic & Medicinal Chemistry, 2006, Huang, Shu-Ting; Hsei, I-Jen; Chen, Chinpiao
The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.
score: 1.070664, Antimicrobial agents and chemotherapy, 2004, Chollet, Renaud et. al.
Paclitaxel binding to human serum albumin—Automated docking studies
score: 1.0705561, Bioorganic & Medicinal Chemistry, 2007, Paal, Krisztina; Shkarupin, Aliaksei; Beckford, Laura
Clinically Relevant Gram-Negative Resistance Mechanisms Have No Effect on the Efficacy of MC-1, a Novel Siderophore-Conjugated Monocarbam.
score: 1.070536, Antimicrobial agents and chemotherapy, 2012, McPherson, Craig J et. al.
Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis.
score: 1.0705217, Antimicrobial agents and chemotherapy, 2003, Ordway, Diane et. al.
Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease.
score: 1.0703946, Antimicrobial agents and chemotherapy, 2009, Waghabi, Mariana C et. al.
Potential for interactions between caspofungin and nelfinavir or rifampin.
score: 1.0703805, Antimicrobial agents and chemotherapy, 2004, Stone, Julie A et. al.
Effect of the extent of thiolation and introduction of phosphorothioate internucleotide linkages on the anti-HIV activity of Suligovir [(s 4dU) 35]
score: 1.0703464, Bioorganic & Medicinal Chemistry Letters, 2006, Horváth, András et. al.
Structural modification of phenylpropanoid-derived compounds and the effects on their participation in redox processes
score: 1.0703184, Bioorganic & Medicinal Chemistry, 2005, Russell, Wendy R.; Scobbie, Lorraine; Chesson, Andrew
Ofloxacin-loaded liposomes: in vitro activity and drug accumulation in bacteria.
score: 1.0702855, Antimicrobial agents and chemotherapy, 2000, Furneri, P M; Fresta, M; Puglisi, G; Tempera, G
Antipneumococcal activities of two novel macrolides, GW 773546 and GW 708408, compared with those of erythromycin, azithromycin, clarithromycin, clindamycin, and telithromycin.
score: 1.0702569, Antimicrobial agents and chemotherapy, 2004, Matic, Vlatka et. al.
Inhibitory effects of 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose on biofilm formation by Staphylococcus aureus.
score: 1.0702456, Antimicrobial agents and chemotherapy, 2011, Lin, Mei-Hui et. al.
Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure–activity relationships
score: 1.0702359, Bioorganic & Medicinal Chemistry, 2006, Hassan Khan, Mahmud Tareq et. al.
Growth-inhibitory effect of heparin on Babesia parasites.
score: 1.0702011, Antimicrobial agents and chemotherapy, 2004, Bork, Sabine et. al.
Activity of pyrazinamide in the guinea pig model of tuberculosis.
score: 1.0701583, Antimicrobial agents and chemotherapy, 2010, Mitchison, Denis A
In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate.
score: 1.0701439, Antimicrobial agents and chemotherapy, 2007, Kyriacou, Helen M et. al.
The synthesis, distribution, and anti-hepatic cancer activity of YSL
score: 1.0701433, Bioorganic & Medicinal Chemistry, 2004, Ding, Wenfeng et. al.
Moxifloxacin (BAY12-8039), a new 8-methoxyquinolone, is active in a mouse model of tuberculosis.
score: 1.070094, Antimicrobial agents and chemotherapy, 1999, Miyazaki, E et. al.
Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients.
score: 1.0700456, Antimicrobial agents and chemotherapy, 2010, Diacon, Andreas H et. al.
QSAR study of flavonoid derivatives as p56lck tyrosinkinase inhibitors
score: 1.0700174, Bioorganic & Medicinal Chemistry, 2004, Thakur, Abhilash; Vishwakarma, S.; Thakur, Mamta
Comparison of censored regression and standard regression analyses for modeling relationships between antimicrobial susceptibility and patient- and institution-specific variables.
score: 1.0699891, Antimicrobial agents and chemotherapy, 2006, Hammel, Jeffrey P et. al.
Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.
score: 1.0699731, Antimicrobial agents and chemotherapy, 2005, Krueger, Wolfgang A et. al.
Host-rotaxanes with oligomeric axles are intracellular transport agents
score: 1.0699218, Bioorganic & Medicinal Chemistry Letters, 2009, Zhu, Jing et. al.
Closing in on the AMPA receptor: Synthesis and evaluation of 2-acetyl-1-(4′-chlorophenyl)-6-methoxy-7-[ 11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer
score: 1.069825, Bioorganic & Medicinal Chemistry, 2006, Årstad, Erik et. al.
First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America.
score: 1.0698237, Antimicrobial agents and chemotherapy, 2006, Villegas, Maria Virginia et. al.
Antifungal therapy in a murine model of disseminated infection by Cryptococcus gattii.
score: 1.0698109, Antimicrobial agents and chemotherapy, 2010, Calvo, Enrique et. al.
Pharmacodynamic profiling of ceftobiprole for treatment of complicated skin and skin structure infections.
score: 1.0698034, Antimicrobial agents and chemotherapy, 2009, Kimko, Holly et. al.
Characterization of dengue virus resistance to brequinar in cell culture.
score: 1.0697046, Antimicrobial agents and chemotherapy, 2010, Qing, Min et. al.
Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment?
score: 1.0696886, Bioorganic & Medicinal Chemistry Letters, 2012, Högberg, Thomas; Frimurer, Thomas M.; Sasmal, Pradip K.
Identification of new triarylethylene oxyalkanoic acid analogues as bone selective estrogen mimetics
score: 1.0696706, Bioorganic & Medicinal Chemistry, 2001, Rubin, Valeria N et. al.
Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC.
score: 1.0696703, Antimicrobial agents and chemotherapy, 1998, Schmitz, F J et. al.
Progress towards understanding β-sheet structure
score: 1.0696686, Bioorganic & Medicinal Chemistry, 1996, Nesloney, Carey L.; Kelly, Jeffery W.
Susceptibility of Chlamydia trachomatis to excipients commonly used in topical microbicide formulations.
score: 1.0696103, Antimicrobial agents and chemotherapy, 2004, Lampe, M F; Rohan, L C; Skinner, M C; Stamm, W E
Quinolones induce partial or total loss of pathogenicity islands in uropathogenic Escherichia coli by SOS-dependent or -independent pathways, respectively.
score: 1.0695936, Antimicrobial agents and chemotherapy, 2006, Soto, S M; Jimenez de Anta, M T; Vila, J
High rate of reduced susceptibility to ciprofloxacin and ceftriaxone among nontyphoid Salmonella clinical isolates in Asia.
score: 1.0695833, Antimicrobial agents and chemotherapy, 2009, Lee, Hao-Yuan et. al.
Base pairing properties of 8-oxo-7,8-dihydroadenosine in cDNA synthesis by reverse transcriptases
score: 1.0695241, Bioorganic & Medicinal Chemistry Letters, 2002, Kim, Sang Kook et. al.
New mimics of the acetate function in pheromone-based attraction
score: 1.0695231, Bioorganic & Medicinal Chemistry, 1996, Hoskovec, Michal et. al.
Efficacy of CS-758, a novel triazole, against experimental fluconazole-resistant oropharyngeal candidiasis in mice.
score: 1.0694739, Antimicrobial agents and chemotherapy, 2003, Kamai, Yasuki et. al.
Sodium lauryl sulfate abrogates human immunodeficiency virus infectivity by affecting viral attachment.
score: 1.0694157, Antimicrobial agents and chemotherapy, 2001, Bestman-Smith, J et. al.
Halogenated Pentamethine Cyanine Dyes Exhibiting High Fidelity for G-Quadruplex DNA
score: 1.0693985, Bioorganic & Medicinal Chemistry, 2012, Nanjunda, Rupesh et. al.
Contribution of specific amino acid changes in penicillin binding protein 1 to amoxicillin resistance in clinical Helicobacter pylori isolates.
score: 1.0693673, Antimicrobial agents and chemotherapy, 2011, Qureshi, Nadia N; Morikis, Dimitrios; Schiller, Neal L
Terbinafine resistance mediated by salicylate 1-monooxygenase in Aspergillus nidulans.
score: 1.0691191, Antimicrobial agents and chemotherapy, 2004, Graminha, Marcia A S et. al.
Red fluorescent scaffold for highly sensitive protease activity probes
score: 1.0691105, Bioorganic & Medicinal Chemistry Letters, 2012, Kushida, Yu et. al.
Unusual class 1 integron-associated gene cassette configuration found in IncA/C plasmids from Salmonella enterica.
score: 1.0690784, Antimicrobial agents and chemotherapy, 2009, Evershed, Nick J et. al.
Cloning and occurrence of czrC, a gene conferring cadmium and zinc resistance in methicillin-resistant Staphylococcus aureus CC398 isolates.
score: 1.0690237, Antimicrobial agents and chemotherapy, 2010, Cavaco, L M et. al.
Studies on 6-Aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones
score: 1.0690088, Bioorganic & Medicinal Chemistry, 1999, Cecchetti, Violetta et. al.
In vitro and in vivo activities of newer fluoroquinolones against Vibrio vulnificus.
score: 1.0689258, Antimicrobial agents and chemotherapy, 2002, Tang, Hung-Jen et. al.
Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae.
score: 1.0688357, Antimicrobial agents and chemotherapy, 2009, Zhao, Shuqing et. al.
Examination of potential mechanisms to explain the association between proton pump inhibitors and Clostridium difficile infection.
score: 1.0687913, Antimicrobial agents and chemotherapy, 2009, Nerandzic, Michelle M; Pultz, Michael J; Donskey, Curtis J
Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs
score: 1.0687864, Bioorganic & Medicinal Chemistry, 2005, López, Gloria V. et. al.
Clonal spread of macrolide- and tetracycline-resistant [erm(A) tet(O)] emm77 Streptococcus pyogenes isolates in Italy and Norway.
score: 1.068775, Antimicrobial agents and chemotherapy, 2006, Palmieri, Claudio et. al.
An unexpected amide bond cleavage: poly (ethylene glycol) transport forms of vancomycin. 2
score: 1.068728, European Journal of Medicinal Chemistry, 2005, Greenwald, Richard B. et. al.
3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity
score: 1.0687204, European Journal of Medicinal Chemistry, 2010, Rocha, F.V. et. al.
Randomized comparison of serum teicoplanin concentrations following daily or alternate daily dosing in healthy adults.
score: 1.0686977, Antimicrobial agents and chemotherapy, 2004, Rouveix, Bernard et. al.
In vitro activities of cefminox against anaerobic bacteria compared with those of nine other compounds.
score: 1.0686168, Antimicrobial agents and chemotherapy, 1998, Hoellman, D B; Spangler, S K; Jacobs, M R; Appelbaum, P C
Promising clinical efficacy of streptomycin-rifampin combination for treatment of buruli ulcer (Mycobacterium ulcerans disease).
score: 1.0686043, Antimicrobial agents and chemotherapy, 2007, Chauty, Annick et. al.
A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists
score: 1.0685899, European Journal of Medicinal Chemistry, 2004, Sestili, Isabella et. al.
Study on the Synthesis and PKA-I Binding Activities of 5-Alkynyl Tubercidin Analogues
score: 1.0685474, Bioorganic & Medicinal Chemistry, 2002, Zhang, Liangren; Zhang, Yunlong; Li, Xianghui; Zhang, Lihe
Synthesis of some new 5-(2-substituted-1,3-thiazol-5-yl)-2-hydroxy benzamides and their 2-alkoxy derivatives as possible antifungal agents
score: 1.0685222, European Journal of Medicinal Chemistry, 2004, Narayana, B. et. al.
Resistance of Yersinia pestis to antimicrobial agents.
score: 1.0684085, Antimicrobial agents and chemotherapy, 2006, Galimand, Marc; Carniel, Elisabeth; Courvalin, Patrice
Monitoring and characterization of extended-spectrum beta-lactamases in Escherichia coli strains from healthy and sick animals in Spain in 2003.
score: 1.0683761, Antimicrobial agents and chemotherapy, 2005, Briñas, Laura et. al.
Role of topoisomerase mutations and efflux in fluoroquinolone resistance of Bacteroides fragilis clinical isolates and laboratory mutants.
score: 1.0683363, Antimicrobial agents and chemotherapy, 2004, Ricci, Vito et. al.
Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase.
score: 1.0681337, Antimicrobial agents and chemotherapy, 2005, Alba, Jimena et. al.
In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates.
score: 1.0681303, Antimicrobial agents and chemotherapy, 2003, Meletiadis, Joseph et. al.
mar Operon involved in multidrug resistance of Enterobacter aerogenes.
score: 1.0681205, Antimicrobial agents and chemotherapy, 2002, Chollet, Renaud et. al.
Structure–activity relationships of benzylidene anabaseines in nicotinic acetylcholine receptors of cockroach nerve cords
score: 1.0681037, Bioorganic & Medicinal Chemistry, 2002, Sultana, Israt; Ikeda, Izumi; Ozoe, Yoshihisa
Pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem, in healthy male Caucasian volunteers.
score: 1.0680741, Antimicrobial agents and chemotherapy, 2006, Shibayama, Takahiro et. al.
Enhancing nicotine vaccine immunogenicity with liposomes
score: 1.0680441, Bioorganic & Medicinal Chemistry Letters, 2013, Lockner, Jonathan W. et. al.
Azole preexposure affects the Aspergillus fumigatus population in patients.
score: 1.0680437, Antimicrobial agents and chemotherapy, 2012, Alanio, Alexandre et. al.
gyrA mutations in ciprofloxacin-resistant Bartonella bacilliformis strains obtained in vitro.
score: 1.0680329, Antimicrobial agents and chemotherapy, 2003, Minnick, Michael F et. al.
Gold nanoparticles functionalized by gadolinium–DTPA conjugate of cysteine as a multimodal bioimaging agent
score: 1.068031, Bioorganic & Medicinal Chemistry Letters, 2010, Park, Ji-Ae et. al.
Pharmacokinetics of once-daily darunavir-ritonavir and atazanavir-ritonavir over 72 hours following drug cessation.
score: 1.0680219, Antimicrobial agents and chemotherapy, 2011, Boffito, Marta et. al.
Idebenone acts against growth of Helicobacter pylori by inhibiting its respiration.
score: 1.0680166, Antimicrobial agents and chemotherapy, 2006, Inatsu, Sakiko; Ohsaki, Ayumi; Nagata, Kumiko
Facile syntheses of the hexasaccharide repeating unit of the exopolysaccharide from Cryptococcus neoformans serovar A
score: 1.0680126, Bioorganic & Medicinal Chemistry, 2003, Zhang, Jianjun; Kong, Fanzuo
Improvement of monolithic solid material by utilization of spacer for identification of the target using affinity resins
score: 1.0680124, Bioorganic & Medicinal Chemistry Letters, 2009, Iwaoka, Emiko et. al.
Defluorinated sparfloxacin as a new photoproduct identified by liquid chromatography coupled with UV detection and tandem mass spectrometry.
score: 1.067849, Antimicrobial agents and chemotherapy, 1998, Engler, M; Rüsing, G; Sörgel, F; Holzgrabe, U
Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir (GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients.
score: 1.0678463, Antimicrobial agents and chemotherapy, 2001, Gilbert, C et. al.
In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates.
score: 1.0678334, Antimicrobial agents and chemotherapy, 2012, Levasseur, Premavathy et. al.
In vitro susceptibility of Pythium insidiosum to macrolides and tetracycline antibiotics.
score: 1.067713, Antimicrobial agents and chemotherapy, 2011, Loreto, Erico Silva et. al.
Effect of dirithromycin on Haemophilus influenzae infection of the respiratory mucosa.
score: 1.0676788, Antimicrobial agents and chemotherapy, 1998, Rutman, A et. al.
Effect of antibiotics on group A Streptococcus exoprotein production analyzed by two-dimensional gel electrophoresis.
score: 1.0676024, Antimicrobial agents and chemotherapy, 2005, Tanaka, Megumi et. al.
Dual DNA recognition codes of a short peptide derived from the basic leucine zipper protein EmBP1
score: 1.0675819, Bioorganic & Medicinal Chemistry, 2005, Hirata, Akiyoshi et. al.
In vitro susceptibility of breakthrough Candida bloodstream isolates correlates with daily and cumulative doses of fluconazole.
score: 1.0675103, Antimicrobial agents and chemotherapy, 2006, Clancy, Cornelius J; Staley, Benjamin; Nguyen, M Hong
Labeling of nucleosides with fluorescent 6-chloro-2,3-napthalimide
score: 1.0674747, Bioorganic & Medicinal Chemistry Letters, 2010, Katritzky, A.R.; Ozcan, S.; Todadze, E.
Anti-AIDS agents. Part 36: 1 17-carboxylated steroids as potential anti-HIV agents
score: 1.067374, Bioorganic & Medicinal Chemistry, 1999, Xia, Peng et. al.
Further insights on the structural aspects of PLA 2 inhibition by γ-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M–R
score: 1.0673276, Bioorganic & Medicinal Chemistry, 2004, Monti, Maria Chiara et. al.
Cyclodextrin retinylidene: A biomimetic kinetic trap model for rhodopsin
score: 1.067313, Bioorganic & Medicinal Chemistry Letters, 2006, Kpegba, Kafui; Murtha, Matthew; Nesnas, Nasri
Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.
score: 1.0672832, Antimicrobial agents and chemotherapy, 2006, Boyd, David A; Miller, Mark A; Mulvey, Michael R
Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect.
score: 1.0672807, Antimicrobial agents and chemotherapy, 2002, Kobayashi, Daisuke et. al.
Complex multiple antibiotic and mercury resistance region derived from the r-det of NR1 (R100).
score: 1.0672556, Antimicrobial agents and chemotherapy, 2004, Partridge, Sally R; Hall, Ruth M
Unusual carbon fixation gives rise to diverse polyketide extender units.
score: 1.0672246, Nature chemical biology, 2011, Quade, Nick et. al.
Striking "seesaw effect" between daptomycin nonsusceptibility and beta-lactam susceptibility in Staphylococcus haemolyticus.
score: 1.0671697, Antimicrobial agents and chemotherapy, 2011, Vignaroli, Carla; Rinaldi, Caterina; Varaldo, Pietro E
Efficacy of liposomal amphotericin B combined with gamma interferon or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice.
score: 1.0671532, Antimicrobial agents and chemotherapy, 2009, Rodríguez, M Mar et. al.
Absolute bioavailability and disposition of (-) and (+) 2'-deoxy- 3'-oxa-4'-thiocytidine (dOTC) following single intravenous and oral doses of racemic dOTC in humans.
score: 1.0671087, Antimicrobial agents and chemotherapy, 2000, Smith, P F; Forrest, A; Ballow, C H; Martin, D E; Proulx, L
Simple and an efficient method for the synthesis of 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol hydrochloride: (±) venlafaxine racemic mixtures
score: 1.0670875, Bioorganic & Medicinal Chemistry Letters, 2004, Basappa, ; Kavitha, C.V.; Rangappa, K.S.
GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate
score: 1.0669393, European Journal of Medicinal Chemistry, 2012, Leurs, Ulrike et. al.
Inhibitors of the tissue factor/factor VIIa-induced coagulation: synthesis and in vitro evaluation of novel 2-aryl substituted pyrido[3,4-d][1,3]-, pyrido[2,3-d][1,3]-, pyrazino[2,3-d][1,3]-, pyrimido[4,5-d][1,3]-, pyrazolo[3,4-d][1,3]-, thieno[3,2-d][1,3]- and thieno[2,3-d][1,3]-oxazin-4-ones
score: 1.0667976, Bioorganic & Medicinal Chemistry, 2000, Jakobsen, Palle; Horneman, Anne Marie; Persson, Egon
Bis[2-(4-carboxyphenoxy)carbonylethyl]phosphinic Acid (BCCEP): A Novel Affinity Reagent for the β-Cleft Modification of Human Hemoglobin
score: 1.0667053, Bioorganic & Medicinal Chemistry, 1998, Hosmane, Ramachandra S. et. al.
Effect of moxifloxacin combined with cefotaxime compared to cefotaxime-gentamicin combination on prevention of white matter damage associated with Escherichia coli sepsis in neonatal rats.
score: 1.0666912, Antimicrobial agents and chemotherapy, 2011, Le Saché, Nolwenn et. al.
Class II transposon-borne structure harboring metallo-beta-lactamase gene blaVIM-2 in Pseudomonas putida.
score: 1.0666821, Antimicrobial agents and chemotherapy, 2006, Poirel, Laurent et. al.
A subset of Staphylococcus aureus strains harboring staphylococcal cassette chromosome mec (SCCmec) type IV is deficient in CcrAB-mediated SCCmec excision.
score: 1.0666737, Antimicrobial agents and chemotherapy, 2006, Noto, Michael J; Archer, Gordon L
Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists
score: 1.0666621, Bioorganic & Medicinal Chemistry, 2004, Kam, Yoo Lim; Rhee, Soo-Jin; Choo, Hea-Young P
Identification of TEM-10 beta-lactamase in a Kluyvera sp. and other Enterobacteriaceae at a Portuguese hospital.
score: 1.0665988, Antimicrobial agents and chemotherapy, 2002, Duarte, A et. al.
VanD-type vancomycin-resistant Enterococcus faecium and Enterococcus faecalis.
score: 1.0665562, Antimicrobial agents and chemotherapy, 2004, Depardieu, Florence et. al.
High-level mupirocin resistance within methicillin-resistant Staphylococcus aureus pandemic lineages.
score: 1.0665447, Antimicrobial agents and chemotherapy, 2006, Pérez-Roth, Eduardo et. al.
Role of penicillin-binding protein 5 in expression of ampicillin resistance and peptidoglycan structure in Enterococcus faecium.
score: 1.0665423, Antimicrobial agents and chemotherapy, 2001, Sifaoui, F; Arthur, M; Rice, L; Gutmann, L
Fluorinated chloramphenicol acetyltransferase thermostability and activity profile: Improved thermostability by a single-isoleucine mutant
score: 1.06636, Bioorganic & Medicinal Chemistry Letters, 2007, Voloshchuk, Natalya et. al.
Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
score: 1.066347, Antimicrobial agents and chemotherapy, 2005, Bakhanashvili, Mary et. al.
The packing of lipid chains changes the character of bacteriorhodopsin reconstituted in a model membrane
score: 1.066307, Bioorganic & Medicinal Chemistry Letters, 2003, Sasaki, Hirotaka et. al.
Antimicrobial resistance of clinical strains of Campylobacter jejuni subsp. jejuni isolated from 1985 to 1997 in Quebec, Canada.
score: 1.0662915, Antimicrobial agents and chemotherapy, 1998, Gaudreau, C; Gilbert, H
Impact of derepressed AmpC beta-lactamase ACT-9 on the clinical efficacy of ertapenem.
score: 1.066265, Antimicrobial agents and chemotherapy, 2011, Lee, Yi-Tzu et. al.
Cyclooctadiene Ru(II) complexes of thiophene-2-carboxaldehyde-derived thiosemicarbazones: synthesis, characterization and antiamoebic activity
score: 1.0662522, European Journal of Medicinal Chemistry, 2006, Singh, Shailendra et. al.
Clonal spread of levofloxacin-resistant streptococcus pneumoniae invasive isolates in Madrid, Spain, 2007 to 2009.
score: 1.0661875, Antimicrobial agents and chemotherapy, 2011, Rodríguez-Avial, Iciar et. al.
Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori.
score: 1.0661875, Antimicrobial agents and chemotherapy, 2003, Gerrits, Monique M et. al.
High prevalence of metallo-beta-lactamase and 16S rRNA methylase coproduction among imipenem-resistant Pseudomonas aeruginosa isolates in Brazil.
score: 1.0661875, Antimicrobial agents and chemotherapy, 2007, Doi, Yohei et. al.
T2182C mutation is not associated with clarithromycin resistance in Helicobacter pylori.
score: 1.0661875, Antimicrobial agents and chemotherapy, 2005, Burucoa, Christophe et. al.
Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.
score: 1.0661766, Antimicrobial agents and chemotherapy, 2005, Mellado, E et. al.
Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa.
score: 1.0661398, Antimicrobial agents and chemotherapy, 2000, Pumbwe, L; Piddock, L J
In vitro activities of the novel cephalosporin LB 11058 against multidrug-resistant Staphylococci and Streptococci.
score: 1.0661396, Antimicrobial agents and chemotherapy, 2004, Sader, Helio S; Johnson, David M; Jones, Ronald N
Synthesis and antibacterial activity of fused Mannich ketones
score: 1.0661164, European Journal of Medicinal Chemistry, 2002, Lóránd, Tamás et. al.
Amino acid substitutions at position 95 in GyrA can add fluoroquinolone resistance to Mycobacterium leprae.
score: 1.0660841, Antimicrobial agents and chemotherapy, 2012, Yokoyama, Kazumasa et. al.
Systematic SAR study of the side chain of nonsecosteroidal vitamin D3 analogs
score: 1.0660466, Bioorganic & Medicinal Chemistry, 2012, Kashiwagi, Hirotaka et. al.
Genetic characterization of antimicrobial resistance in Canadian isolates of Salmonella serovar Typhimurium DT104.
score: 1.0659187, Antimicrobial agents and chemotherapy, 1999, Ng, L K; Mulvey, M R; Martin, I; Peters, G A; Johnson, W
Pharmacokinetic-pharmacodynamic relationship of arbekacin for treatment of patients infected with methicillin-resistant Staphylococcus aureus.
score: 1.0658588, Antimicrobial agents and chemotherapy, 2006, Sato, Reiko et. al.
Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1 H-indole-3-carboxylates
score: 1.0658583, Bioorganic & Medicinal Chemistry, 2006, Zhao, Chunshen; Zhao, Yanfang; Chai, Huifang; Gong, Ping
Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.
score: 1.0658425, Antimicrobial agents and chemotherapy, 1999, Brisse, S et. al.
Escherichia coli producing an ACC-1 class C beta-lactamase isolated in Barcelona, Spain.
score: 1.0657882, Antimicrobial agents and chemotherapy, 2005, Miró, Elisenda et. al.
Need for additional, specific information in studies with echinacea.
score: 1.0657865, Antimicrobial agents and chemotherapy, 2001, Dennehy, C
The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry
score: 1.0657862, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Baohua et. al.
Application of an in vitro infection model and simulation for reevaluation of fluoroquinolone breakpoints for Salmonella enterica serotype typhi.
score: 1.0657325, Antimicrobial agents and chemotherapy, 2005, Booker, Brent M et. al.
Theoretical descriptors in quantitative structure–affinity and selectivity relationship study of potent N4-substituted arylpiperazine 5-HT1 A receptor antagonists
score: 1.065721, Bioorganic & Medicinal Chemistry, 1998, Menziani, M.C; De Benedetti, P.G; Karelson, M
A First-in-Human, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study To Assess the Safety and Tolerability of LFF571 in Healthy Volunteers.
score: 1.0657139, Antimicrobial agents and chemotherapy, 2012, Ting, Lillian S L et. al.
Comparison of the dynamics of resistance-associated mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors after cessation of antiretroviral combination therapy.
score: 1.0656556, Antimicrobial agents and chemotherapy, 2004, Wirden, Marc et. al.
Epidemiology of invasive meningococcal disease with decreased susceptibility to penicillin in Ontario, Canada, 2000 to 2006.
score: 1.0656487, Antimicrobial agents and chemotherapy, 2010, Brown, Elizabeth M et. al.
gyrA polymorphism in Campylobacter jejuni: detection of gyrA mutations in 162 C. jejuni isolates by single-strand conformation polymorphism and DNA sequencing.
score: 1.0656309, Antimicrobial agents and chemotherapy, 2002, Hakanen, Antti et. al.
Systematic review and meta-analysis of the effectiveness and safety of tigecycline for treatment of infectious disease.
score: 1.0656001, Antimicrobial agents and chemotherapy, 2011, Cai, Yun; Wang, Rui; Liang, Beibei; Bai, Nan; Liu, Youning
nimE gene in a metronidazole-susceptible Veillonella sp. strain.
score: 1.0655786, Antimicrobial agents and chemotherapy, 2004, Marchandin, H et. al.
Mitogen-activated protein kinase 4 of Leishmania parasite as a therapeutic target
score: 1.0655168, European Journal of Medicinal Chemistry, 2010, Saravanan, Parameswaran et. al.
Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds
score: 1.0654632, European Journal of Medicinal Chemistry, 2010, Rosu, Tudor et. al.
Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,1′-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)
score: 1.0654441, European Journal of Medicinal Chemistry, 2010, Wouters, Johan et. al.
Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,1′-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)
score: 1.0654441, European Journal of Medicinal Chemistry, 2010, Wouters, Johan et. al.
Reversal of tetracycline resistance mediated by different bacterial tetracycline resistance determinants by an inhibitor of the Tet(B) antiport protein.
score: 1.0654344, Antimicrobial agents and chemotherapy, 1999, Nelson, M L; Levy, S B
Synthesis and insecticidal activity of novel N-oxydihydropyrroles: 4-hydroxy-3-mesityl-1-methoxymethoxy derivatives with various substituents at the 5-position
score: 1.065369, Bioorganic & Medicinal Chemistry, 2003, Ito, Mitsuru et. al.
Synthesis and biological evaluation of a novel 99mTc(CO) 3 complex of ciprofloxacin dithiocarbamate as a potential agent to target infection
score: 1.0653543, Bioorganic & Medicinal Chemistry Letters, 2010, Zhang, Junbo; Zhang, Shijian; Guo, Haixun; Wang, Xuebin
Anti-adipogenic chromone glycosides from Cnidium monnieri fruits in 3T3-L1 cells
score: 1.0653411, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Seon Beom et. al.
Inspired by flowers: Synthetic routes to scalemic deltamethrinic acid
score: 1.0653229, Bioorganic & Medicinal Chemistry, 2009, Krief, Alain; Jeanmart, Stephane; Kremer, Adrian
Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans.
score: 1.0653206, Antimicrobial agents and chemotherapy, 2002, Morin, Anne-Sophie et. al.
Pharmacokinetic profile of tigecycline in serum and skin blister fluid of healthy subjects after multiple intravenous administrations.
score: 1.0652861, Antimicrobial agents and chemotherapy, 2005, Sun, Heather K et. al.
Prospective survey of beta-lactamases produced by ceftazidime- resistant Pseudomonas aeruginosa isolated in a French hospital in 2000.
score: 1.0652373, Antimicrobial agents and chemotherapy, 2002, De Champs, Christophe et. al.
Synthesis of TDP-3-amino-3,4,6-trideoxy-α- d- xylo-hexopyranose—The immediate precursor of TDP-α- d-desosamine
score: 1.0651387, Bioorganic & Medicinal Chemistry Letters, 2002, Chang, Cheng-Wei T.; Liu, Hung-wen
Human immunodeficiency virus polymorphisms and zidovudine resistance.
score: 1.0651147, Antimicrobial agents and chemotherapy, 2003, Nicastri, Emanuele et. al.
Antimicrobial susceptibilities of group B streptococci isolated from patients with invasive disease: 10-year perspective.
score: 1.0650475, Antimicrobial agents and chemotherapy, 2001, Murdoch, D R; Reller, L B
Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins
score: 1.0650452, Bioorganic & Medicinal Chemistry, 2004, He, Xungui et. al.
Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy.
score: 1.0649431, Antimicrobial agents and chemotherapy, 2010, Tumbarello, Mario et. al.
Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.
score: 1.064934, Antimicrobial agents and chemotherapy, 2003, Chenel, Marylore et. al.
Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae.
score: 1.0649148, Antimicrobial agents and chemotherapy, 2008, Rodríguez, M Mar et. al.
Nonspecific effect of Mycograb on amphotericin B MIC.
score: 1.0649048, Antimicrobial agents and chemotherapy, 2012, Richie, D L et. al.
Bioactive Briarane Diterpenoids from the South China Sea Gorgonian Dichotella gemmacea
score: 1.0648579, Bioorganic & Medicinal Chemistry Letters, 2012, Li, Cui et. al.
Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.
score: 1.064833, Antimicrobial agents and chemotherapy, 2002, Kern, Earl R et. al.
Inhibition of classical pathway of complement activation with negative charged derivatives of bisphenol A and bisphenol disulphates
score: 1.0647814, Bioorganic & Medicinal Chemistry, 2005, Bureeva, Svetlana et. al.
Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn
score: 1.0647759, Bioorganic & Medicinal Chemistry, 2013, Vaijayanthi, Thangavel et. al.
GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate
score: 1.0647652, European Journal of Medicinal Chemistry, 2012, Leurs, Ulrike et. al.
Enzymatic Polymerisation Involving 2’-amino-LNA Nucleotides
score: 1.0647061, Bioorganic & Medicinal Chemistry Letters, 2012, Johannsen, Marie W. et. al.
Connection between trimethoprim-sulfamethoxazole use and resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
score: 1.0647015, Antimicrobial agents and chemotherapy, 2008, Kärpänoja, Pauliina et. al.
‘Inverted’ analogs of the antibiotic gramicidin S with an improved biological profile
score: 1.0646763, Bioorganic & Medicinal Chemistry, 2012, Kapoerchan, Varsha V. et. al.
Mycobacterium leprae is naturally resistant to PA-824.
score: 1.0646319, Antimicrobial agents and chemotherapy, 2006, Manjunatha, Ujjini H et. al.
In vitro activities of tigecycline (GAR-936) against multidrug-resistant Staphylococcus aureus and Streptococcus pneumoniae.
score: 1.0646305, Antimicrobial agents and chemotherapy, 2004, Kitzis, M D; Ly, A; Goldstein, F W
In vitro activities of the des-fluoro(6) Quinolone BMS-284756 against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections.
score: 1.0646301, Antimicrobial agents and chemotherapy, 2002, Goldstein, Ellie J C et. al.
Design, synthesis, and biological evaluation of non-peptidic ligands at the Xenopus laevis skin-melanocortin receptor
score: 1.0644127, European Journal of Medicinal Chemistry, 2003, Tammler, Ursula et. al.
Highly water-soluble matrix metalloproteinases inhibitors and their effects in a rat adjuvant-induced arthritis model
score: 1.0643082, Bioorganic & Medicinal Chemistry, 2002, Fujisawa, Tetsunori et. al.
Frequent emergence of resistance in Clostridium difficile during treatment of C. difficile-associated diarrhea with fusidic acid.
score: 1.0643054, Antimicrobial agents and chemotherapy, 2006, Norén, T et. al.
Specific binding of 2-amino-1,8-naphthyridine into a single guanine bulge as evidenced by photooxidation of GG doublet
score: 1.0643015, Bioorganic & Medicinal Chemistry Letters, 2001, Nakatani, Kazuhiko et. al.
Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae.
score: 1.0642369, Antimicrobial agents and chemotherapy, 2005, Smith, Anthony M et. al.
Pharmacokinetics of ethambutol under fasting conditions, with food, and with antacids.
score: 1.0642174, Antimicrobial agents and chemotherapy, 1999, Peloquin, C A et. al.
Antioxidant activities of flavidin in different in vitro model systems
score: 1.0642016, Bioorganic & Medicinal Chemistry, 2004, Jayaprakasha, Guddadarangavvanahally K. et. al.
Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients.
score: 1.0641165, Antimicrobial agents and chemotherapy, 2004, Wood, Robin et. al.
beta-Lactam MICs correlate poorly with mutant prevention concentrations for clinical isolates of Acinetobacter spp. and Pseudomonas aeruginosa.
score: 1.0641069, Antimicrobial agents and chemotherapy, 2006, Gugel, Juliana et. al.
Aminoethyl-substituted indole-3-acetic acids for the preparation of tagged and carrier-linked auxin
score: 1.0639481, Bioorganic & Medicinal Chemistry, 2005, Ilić, Nebojša et. al.
Efficacy of daptomycin versus vancomycin in an experimental model of foreign-body and systemic infection caused by biofilm producers and methicillin-resistant Staphylococcus epidermidis.
score: 1.0638611, Antimicrobial agents and chemotherapy, 2012, Domínguez-Herrera, J et. al.
Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen
score: 1.0638281, Bioorganic & Medicinal Chemistry, 2012, Miyano, Yuka et. al.
Synthesis and study of some 4-aza and 17a-azasteroidal isoxazoles
score: 1.0638197, European Journal of Medicinal Chemistry, 1999, Gupta, Ranju; Pathak, Devender; Jindal, Dharam P.
Characterization of tet(32) genes from the oral metagenome.
score: 1.0638029, Antimicrobial agents and chemotherapy, 2009, Warburton, Philip et. al.
Polymer-supported chiral catalysts with positive support effects
score: 1.0637643, Bioorganic & Medicinal Chemistry Letters, 2002, Fan, Qing-Hua; Wang, Rui; Chan, Albert S.C
Synthesis, characterization and cytotoxicity evaluation of some new platinum(II) complexes of tetrazolo[1,5-a]quinolines
score: 1.0637574, European Journal of Medicinal Chemistry, 2004, Bekhit, Adnan A et. al.
Structure–activity relationships of sandalwood odorants: Total synthesis and fragrance properties of cyclopropano-β-santalol
score: 1.0637438, European Journal of Medicinal Chemistry, 2008, Stappen, Iris et. al.
Functional characterization of a Cassette-specific promoter in the class 1 integron-associated qnrVC1 gene.
score: 1.0637345, Antimicrobial agents and chemotherapy, 2012, da Fonseca, Érica Lourenço; Vicente, Ana Carolina Paulo
Emission of characteristic fluorescence from the ligand–cytosine complex in U_A/ACU bulged RNA duplex
score: 1.0637116, Bioorganic & Medicinal Chemistry, 2007, Zhang, Jinhua; Takei, Fumie; Nakatani, Kazuhiko
New reporter cell line to evaluate the sequential emergence of multiple human cytomegalovirus mutations during in vitro drug exposure.
score: 1.0637046, Antimicrobial agents and chemotherapy, 2005, Gilbert, C; Boivin, G
Hypermutable and fluoroquinolone-resistant clinical isolates of Staphylococcus aureus.
score: 1.0636227, Antimicrobial agents and chemotherapy, 2005, Trong, Hiep N'Guyen; Prunier, Anne-Laure; Leclercq, Roland
Reply to "Lack of Evidence for Reduced Fitness of Clinical Staphylococcus aureus Isolates with Reduced Susceptibility to Triclosan".
score: 1.0635631, Antimicrobial agents and chemotherapy, 2012, McBain, Andrew J; Forbes, Sarah; Latimer, Joe
Heterobifunctional PEGs: Efficient synthetic strategies and useful conjugation methodologies
score: 1.063521, Bioorganic & Medicinal Chemistry Letters, 2010, Levy, Daniel E. et. al.
Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia.
score: 1.0634146, Antimicrobial agents and chemotherapy, 2002, Petraitiene, Ruta et. al.
Chemical constituents from the fruit ofGardenia jasminoidesand their inhibitory effects on nitric oxide production
score: 1.0633711, Bioorganic & Medicinal Chemistry Letters, 2013, Peng, Kaifeng et. al.
First identification of OXA-72 carbapenemase from Acinetobacter pittii in Colombia.
score: 1.0632775, Antimicrobial agents and chemotherapy, 2012, Montealegre, Maria Camila et. al.
Alpha interferon augments cidofovir's antiviral and antiproliferative activities.
score: 1.0632194, Antimicrobial agents and chemotherapy, 2003, Johnson, Jeffrey A; Gangemi, J David
Early endpoints for acute bacterial skin and skin structure infections.
score: 1.0632095, Antimicrobial agents and chemotherapy, 2012, Drusano, George L
RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family.
score: 1.0632018, Antimicrobial agents and chemotherapy, 2012, Galimand, Marc; Courvalin, Patrice; Lambert, Thierry
Synthesis and immunochemical characterization of protein conjugates of carbohydrate and carbohydrate-mimetic peptides as experimental vaccines
score: 1.0631627, Bioorganic & Medicinal Chemistry, 2004, Hossany, Rehana B et. al.
Dogs of nomadic pastoralists in northern Kenya are reservoirs of plasmid-mediated cephalosporin- and quinolone-resistant Escherichia coli, including pandemic clone B2-O25-ST131.
score: 1.0631559, Antimicrobial agents and chemotherapy, 2012, Albrechtova, Katerina et. al.
A solid-phase approach to novel purine and nucleoside analogs
score: 1.0629589, Bioorganic & Medicinal Chemistry, 2005, Chang, Junbiao et. al.
The effect of the length and flexibility of the side chain of basic amino acids on the binding of antimicrobial peptides to zwitterionic and anionic membrane model systems
score: 1.0629243, Bioorganic & Medicinal Chemistry, 2012, Russell, Amanda L. et. al.
In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis.
score: 1.0629036, Antimicrobial agents and chemotherapy, 2003, Goldstein, Ellie J C et. al.
Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence.
score: 1.0628779, Antimicrobial agents and chemotherapy, 2011, Tsai, Yu-Kuo et. al.
Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.
score: 1.0628123, Antimicrobial agents and chemotherapy, 2003, Faldynova, M et. al.
Correlation between pretreatment levels of interferon response genes and clinical responses to an immune response modifier (Imiquimod) in genital warts.
score: 1.062801, Antimicrobial agents and chemotherapy, 2000, Arany, I et. al.
Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections.
score: 1.062793, Antimicrobial agents and chemotherapy, 2007, Kwiek, Jesse J et. al.
Genetic environment and expression of the extended-spectrum beta-lactamase blaPER-1 gene in gram-negative bacteria.
score: 1.0627153, Antimicrobial agents and chemotherapy, 2005, Poirel, Laurent et. al.
An analysis of the ‘legal high’ mephedrone
score: 1.0627105, Bioorganic & Medicinal Chemistry Letters, 2010, Gibbons, Simon; Zloh, Mire
Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring
score: 1.0626806, Bioorganic & Medicinal Chemistry, 2003, Tapia, Ricardo A. et. al.
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.
score: 1.0626342, Antimicrobial agents and chemotherapy, 2006, Hostetler, Karl Y et. al.
Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.
score: 1.0626199, Antimicrobial agents and chemotherapy, 2011, Moore, Brioni R et. al.
Macrolide resistance in Peptostreptococcus spp. mediated by ermTR: possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes.
score: 1.0625614, Antimicrobial agents and chemotherapy, 2001, Reig, M; Galan, J; Baquero, F; Perez-Diaz, J C
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.
score: 1.0624901, Antimicrobial agents and chemotherapy, 1999, Price, R N et. al.
Combination chemotherapy against Clonorchis sinensis: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in a rat model.
score: 1.0624786, Antimicrobial agents and chemotherapy, 2009, Keiser, Jennifer et. al.
In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli.
score: 1.0623398, Antimicrobial agents and chemotherapy, 2010, Urban, Carl; Mariano, Noriel; Rahal, James J
Resistance Emergence Mechanism and Mechanism of Resistance Suppression by Tobramycin for Cefepime for Pseudomonas aeruginosa.
score: 1.0622685, Antimicrobial agents and chemotherapy, 2012, Drusano, G L et. al.
Chlamydia pneumoniae resists antibiotics in lymphocytes.
score: 1.0622541, Antimicrobial agents and chemotherapy, 2003, Yamaguchi, Hiroyuki et. al.
Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity
score: 1.0622305, Bioorganic & Medicinal Chemistry, 2005, Tao, Guoxin; Irie, Yoshifumi; Li, Dian-Jun; Keung, Wing Ming
Phenotype and molecular characterization of the first inhibitor-resistant TEM-derived beta-lactamase identified in Portugal.
score: 1.0621962, Antimicrobial agents and chemotherapy, 2002, Caniça, Manuela et. al.
Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting.
score: 1.0621595, Nature chemical biology, 2009, Fisch, Katja M et. al.
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B 1–DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin
score: 1.0621512, Bioorganic & Medicinal Chemistry, 1998, Raj, Hanumantharao G et. al.
Optimizing second-line therapy for drug-resistant tuberculosis: the additive value of sequencing for multiple resistance loci.
score: 1.0621462, Antimicrobial agents and chemotherapy, 2011, Heysell, Scott K; Houpt, Eric R
Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump.
score: 1.0620914, Antimicrobial agents and chemotherapy, 2005, Chuanchuen, Rungtip et. al.
Probing the activation site of ribonuclease L with new N 6-substituted 2′,5′-adenylate trimers
score: 1.0620188, Bioorganic & Medicinal Chemistry, 2003, Münch, Ursula et. al.
Efficacy of short-course ceftriaxone therapy for Borrelia burgdorferi infection in C3H mice.
score: 1.0619845, Antimicrobial agents and chemotherapy, 2002, Pavia, Charles; Inchiosa, Mario A; Wormser, Gary P
Method for estimation of low outer membrane permeability to beta-lactam antibiotics.
score: 1.0619779, Antimicrobial agents and chemotherapy, 2002, Lakaye, Bernard et. al.
Results obtained with various antifungal susceptibility testing methods do not predict early clinical outcome in patients with cryptococcosis.
score: 1.0619722, Antimicrobial agents and chemotherapy, 2006, Dannaoui, E et. al.
Introduction of the mec element (methicillin resistance) into Staphylococcus aureus alters in vitro functional activities of fibrinogen and fibronectin adhesins.
score: 1.0619678, Antimicrobial agents and chemotherapy, 1998, Vaudaux, P E et. al.
In vitro activity and fecal concentration of rifaximin after oral administration.
score: 1.061964, Antimicrobial agents and chemotherapy, 2000, Jiang, Z D; Ke, S; Palazzini, E; Riopel, L; Dupont, H
Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium
score: 1.0619047, Bioorganic & Medicinal Chemistry Letters, 2006, Auernheimer, Jörg; Kessler, Horst
Determinants of rifampin, isoniazid, pyrazinamide, and ethambutol pharmacokinetics in a cohort of tuberculosis patients.
score: 1.0619034, Antimicrobial agents and chemotherapy, 2006, McIlleron, Helen et. al.
Optimized elution of daptomycin from polymethylmethacrylate beads.
score: 1.0619003, Antimicrobial agents and chemotherapy, 2009, Weiss, Brian D et. al.
Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus.
score: 1.0618417, Antimicrobial agents and chemotherapy, 2012, Tsuji, Brian T et. al.
Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs.
score: 1.0618358, Antimicrobial agents and chemotherapy, 2011, Shang, Shaobin et. al.
The peptide hormone ghrelin binds to membrane-mimetics via its octanoyl chain and an adjacent phenylalanine
score: 1.0618218, Bioorganic & Medicinal Chemistry, 2010, Großauer, Jörg et. al.
In vitro activities of polymyxin B, imipenem, and rifampin against multidrug-resistant Acinetobacter baumannii.
score: 1.0617781, Antimicrobial agents and chemotherapy, 2006, Wareham, D W; Bean, D C
A 3,4-Epoxypiperidine structure as a novel and simple DNA-cleavage unit
score: 1.0617618, Bioorganic & Medicinal Chemistry Letters, 2002, Miyashita, Kazuyuki et. al.
Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma
score: 1.061734, Bioorganic & Medicinal Chemistry, 1999, Fukuda, Hiroyuki et. al.
Nasal carriage in Vietnamese children of Streptococcus pneumoniae resistant to multiple antimicrobial agents.
score: 1.0617087, Antimicrobial agents and chemotherapy, 2000, Parry, C M et. al.
Synthesis and kinetic studies of an amidine-containing phosphonofluoridate: a novel potent inhibitor of trypsin-like enzymes
score: 1.0616634, Bioorganic & Medicinal Chemistry, 1998, Ni, Li-Ming; Powers, James C.
Mechanism of action of NB2001 and NB2030, novel antibacterial agents activated by beta-lactamases.
score: 1.0616326, Antimicrobial agents and chemotherapy, 2004, Stone, Geoffrey W et. al.
Exploration of the DTrp-NMeLys Motif in the Search for potent somatostatin antagonists
score: 1.0615036, Bioorganic & Medicinal Chemistry, 2002, Rajeswaran, W.G et. al.
Loss of the homotypic fusion and vacuole protein sorting or golgi-associated retrograde protein vesicle tethering complexes results in gentamicin sensitivity in the yeast Saccharomyces cerevisiae.
score: 1.0614857, Antimicrobial agents and chemotherapy, 2006, Wagner, Mark C et. al.
A single oral dose of thalidomide enhances the capacity of lymphocytes to secrete gamma interferon in healthy humans.
score: 1.0614397, Antimicrobial agents and chemotherapy, 2000, Verbon, A et. al.
Synthesis, in vitro and in vivo studies of Gd-DTPA-XDA-D1-Glc(OH) complex as a new potential MRI contrast agent
score: 1.0613309, Bioorganic & Medicinal Chemistry Letters, 2010, Ozaki, Nobuhisa et. al.
Possible role of hydroxyl radicals in the oxidative degradation of folic acid
score: 1.0613291, Bioorganic & Medicinal Chemistry Letters, 2005, Patro, Birija S. et. al.
Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.
score: 1.061307, Antimicrobial agents and chemotherapy, 2005, Park, S et. al.
High-level resistance to trimethoprim in clinical isolates of Campylobacter jejuni by acquisition of foreign genes (dfr1 and dfr9) expressing drug-insensitive dihydrofolate reductases.
score: 1.0612886, Antimicrobial agents and chemotherapy, 1998, Gibreel, A; Sköld, O
Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: Influence of sex and inhibitors
score: 1.0612869, Bioorganic & Medicinal Chemistry, 2006, Klecker, Raymond W.; Cysyk, Richard L.; Collins, Jerry M.
Antiviral therapy reduces viral burden but does not prevent thymic involution in young cats infected with feline immunodeficiency virus.
score: 1.0612628, Antimicrobial agents and chemotherapy, 2000, Hayes, K A; Phipps, A J; Francke, S; Mathes, L E
Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections.
score: 1.0612515, Antimicrobial agents and chemotherapy, 2005, Lenaerts, L; Verbeken, E; De Clercq, E; Naesens, L
DNA hydrolysis promoted by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane
score: 1.0612514, Bioorganic & Medicinal Chemistry Letters, 2006, Wan, Shu-Hui et. al.
Biocatalytic ammonolysis of (5 S)-4,5-dihydro-1 H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester: Preparation of an intermediate to the dipeptidyl peptidase IV inhibitor Saxagliptin
score: 1.0612389, Bioorganic & Medicinal Chemistry Letters, 2006, Gill, Iqbal; Patel, Ramesh
Potential applications of nicotinic ligands in the laboratory and clinic
score: 1.0611307, Bioorganic & Medicinal Chemistry Letters, 2004, Dani, J.A et. al.
Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase.
score: 1.0611023, Antimicrobial agents and chemotherapy, 2000, Kim, W S; Wang, Y; Fang, A; Demain, A L
Replacement of broad-spectrum cephalosporins by piperacillin-tazobactam: impact on sustained high rates of bacterial resistance.
score: 1.0610841, Antimicrobial agents and chemotherapy, 2004, Bantar, Carlos et. al.
Diversity, epidemiology, and genetics of class D beta-lactamases.
score: 1.0610794, Antimicrobial agents and chemotherapy, 2010, Poirel, Laurent; Naas, Thierry; Nordmann, Patrice
Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility.
score: 1.0610472, Antimicrobial agents and chemotherapy, 2001, Smith, A M; Botha, R F; Koornhof, H J; Klugman, K P
Risk factors for new detection of vancomycin-resistant enterococci in acute-care hospitals that employ strict infection control procedures.
score: 1.0608419, Antimicrobial agents and chemotherapy, 2003, Padiglione, Alexander A et. al.
A ‘cassette’ RNase
score: 1.0607846, Bioorganic & Medicinal Chemistry Letters, 2001, Futaki, Shiroh et. al.
Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 Pneumococci from 10 central and Eastern European countries.
score: 1.0607832, Antimicrobial agents and chemotherapy, 2002, Nagai, Kensuke et. al.
International retrospective analysis of 73 cases of invasive fusariosis treated with voriconazole.
score: 1.0607565, Antimicrobial agents and chemotherapy, 2010, Lortholary, Olivier et. al.
In Vitro Synergy Between Clofazimine And Amikacin in Nontuberculous Mycobacterial Disease.
score: 1.06074, Antimicrobial agents and chemotherapy, 2012, van Ingen, Jakko et. al.
Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides.
score: 1.060617, Antimicrobial agents and chemotherapy, 2000, Rosenau, A et. al.
Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition.
score: 1.060614, Antimicrobial agents and chemotherapy, 2003, Tribuddharat, Chanwit et. al.
Improved CILAT reagents for quantitative proteomics
score: 1.0604164, Bioorganic & Medicinal Chemistry Letters, 2009, Zeng, Dexing; Li, Shuwei
Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.
score: 1.0603704, Antimicrobial agents and chemotherapy, 1998, Lopez-Ribot, J L et. al.
Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
score: 1.0603409, Antimicrobial agents and chemotherapy, 2006, Onyewu, Chiatogu; Afshari, Natalie A; Heitman, Joseph
Enzymatic synthesis of S- adenosyl- l-methionine on the preparative scale
score: 1.0603056, Bioorganic & Medicinal Chemistry, 1996, Park, Jeongho et. al.
Synthesis and characterization of selective dopamine D 2 receptor antagonists
score: 1.0602942, Bioorganic & Medicinal Chemistry, 2006, Vangveravong, Suwanna et. al.
Widespread distribution of a tet W determinant among tetracycline-resistant isolates of the animal pathogen Arcanobacterium pyogenes.
score: 1.0602484, Antimicrobial agents and chemotherapy, 2002, Billington, Stephen J; Songer, J Glenn; Jost, B Helen
Synthesis, characterization and cytotoxicity of new platinum(IV) axial carboxylate complexes: crystal structure of potential antitumor agent [Pt IV( trans-1 R,2 R-diaminocyclohexane) trans(acetate) 2Cl 2]
score: 1.0602336, Bioorganic & Medicinal Chemistry, 2000, Ali Khan, S.Rounaq et. al.
Plasmid-mediated 16S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides.
score: 1.0601799, Antimicrobial agents and chemotherapy, 2004, Doi, Yohei et. al.
Association of extended-spectrum β-lactamase VEB-5 and 16S rRNA methyltransferase armA in Salmonella enterica from the United Kingdom.
score: 1.0601303, Antimicrobial agents and chemotherapy, 2012, Hidalgo, Laura et. al.
No Recurrence of Pneumocystis jirovecii Pneumonia after Solid Organ Transplantation Regardless of Secondary Prophylaxis.
score: 1.0601181, Antimicrobial agents and chemotherapy, 2012, Kim, Tark et. al.
In vitro activity of JPC 2067 alone and in combination with sulfamethoxazole against nocardia species.
score: 1.0600626, Antimicrobial agents and chemotherapy, 2012, Mookherjee, Swagatam; Shoen, Carolyn; Cynamon, Michael
Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents
score: 1.0600433, European Journal of Medicinal Chemistry, 2012, Yıldırım, Tuba et. al.
Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread.
score: 1.0599101, Antimicrobial agents and chemotherapy, 2004, Cheshenko, Natalia et. al.
Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study.
score: 1.0598467, Antimicrobial agents and chemotherapy, 2012, Kim, So Hyun et. al.
Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark.
score: 1.0598317, Antimicrobial agents and chemotherapy, 2001, Aarestrup, F M et. al.
An improved route to 1,2-dideoxy-β-1-phenyl- d-ribofuranose
score: 1.059752, Bioorganic & Medicinal Chemistry Letters, 1998, Wichai, Uthai; Woski, Stephen A.
Orally administered recombinant metallo-beta-lactamase preserves colonization resistance of piperacillin-tazobactam-treated mice.
score: 1.0597488, Antimicrobial agents and chemotherapy, 2005, Stiefel, Usha et. al.
Efficacy of linezolid in experimental otitis media.
score: 1.0597396, Antimicrobial agents and chemotherapy, 2000, Pelton, S I; Figueira, M; Albut, R; Stalker, D
Structure–activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters
score: 1.0596561, Bioorganic & Medicinal Chemistry, 2001, Scapecchi, S. et. al.
Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
score: 1.0595797, Bioorganic & Medicinal Chemistry Letters, 2004, Lorenz, Christina et. al.
Identification of vat(E-3), a novel gene encoding resistance to quinupristin-dalfopristin in a strain of Enterococcus faecium from a hospital patient in the United Kingdom.
score: 1.0595064, Antimicrobial agents and chemotherapy, 2001, Soltani, M; Beighton, D; Philpott-Howard, J; Woodford, N
The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine
score: 1.0594875, European Journal of Medicinal Chemistry, 2010, Ramos-Lima, Francisco J. et. al.
Genomic approach to identifying the putative target of and mechanisms of resistance to mefloquine in mycobacteria.
score: 1.0594859, Antimicrobial agents and chemotherapy, 2005, Danelishvili, Lia et. al.
Resistance to mercury and antimicrobial agents in Streptococcus mutans isolates from human subjects in relation to exposure to dental amalgam fillings.
score: 1.0594701, Antimicrobial agents and chemotherapy, 2000, Leistevuo, J et. al.
Ultrasonically controlled release of ciprofloxacin from self-assembled coatings on poly(2-hydroxyethyl methacrylate) hydrogels for Pseudomonas aeruginosa biofilm prevention.
score: 1.059456, Antimicrobial agents and chemotherapy, 2005, Norris, P et. al.
Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits.
score: 1.0594462, Antimicrobial agents and chemotherapy, 2004, Petraitiene, Ruta et. al.
Pharmacokinetic interaction study of ritonavir-boosted saquinavir in combination with rifabutin in healthy subjects.
score: 1.0593905, Antimicrobial agents and chemotherapy, 2011, Zhang, Xiaoping et. al.
The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K + channels of the alga Nitella hookeri
score: 1.0593387, Bioorganic & Medicinal Chemistry Letters, 2003, Giles, Kristian R et. al.
Antimicrobial susceptibilities of Porphyromonas gingivalis, Prevotella intermedia, and Prevotella nigrescens spp. isolated in Spain.
score: 1.0592479, Antimicrobial agents and chemotherapy, 1998, Andrés, M T; Chung, W O; Roberts, M C; Fierro, J F
Antimicrobial susceptibilities of Campylobacter jejuni isolates from poultry from Alberta, Canada.
score: 1.0591991, Antimicrobial agents and chemotherapy, 2006, Kos, Veronica N; Keelan, Monika; Taylor, Diane E
Intelligent fluorescent nucleoside in sensing cytosine base: Importance of hydrophobic nature of perylene fluorophore
score: 1.0591399, Bioorganic & Medicinal Chemistry Letters, 2006, Bag, Subhendu Sekhar et. al.
In vitro interactions of micafungin with other antifungal drugs against clinical isolates of four species of Cryptococcus.
score: 1.0591273, Antimicrobial agents and chemotherapy, 2005, Serena, Carolina et. al.
Peptide T-araC conjugates: solid-phase synthesis and biological activity of N 4-(acylpeptidyl)-araC
score: 1.0591122, Bioorganic & Medicinal Chemistry, 2000, Manfredini, Stefano et. al.
Phototargeting oral black-pigmented bacteria.
score: 1.0591066, Antimicrobial agents and chemotherapy, 2005, Soukos, Nikolaos S et. al.
The vanB2 gene cluster of the majority of vancomycin-resistant Enterococcus faecium isolates from Taiwan is associated with the pbp5 gene and is carried by Tn5382 containing a novel insertion sequence.
score: 1.0590585, Antimicrobial agents and chemotherapy, 2005, Lu, Jang-Jih et. al.
Synthesis and evaluation of cytotoxic activity of arylfurans
score: 1.0588182, European Journal of Medicinal Chemistry, 2006, de Oliveira, Renata B. et. al.
Search for the Optimal Linker in Tandem Hairpin Polyamides
score: 1.0587963, Bioorganic & Medicinal Chemistry, 2002, Kers, Inger; Dervan, Peter B
5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis.
score: 1.0587795, Antimicrobial agents and chemotherapy, 2006, Upcroft, Jacqueline A et. al.
Rediscovery of known natural compounds: Nuisance or goldmine?
score: 1.0587607, Bioorganic & Medicinal Chemistry, 2005, Tulp, Martin; Bohlin, Lars
Cyclooxygenase inhibitors – current status and future prospects
score: 1.0587373, European Journal of Medicinal Chemistry, 2001, Dannhardt, Gerd; Kiefer, Werner
Longitudinal assessment of antipneumococcal susceptibility in the United States.
score: 1.0587324, Antimicrobial agents and chemotherapy, 2002, Jones, Mark E et. al.
Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans.
score: 1.0586789, Antimicrobial agents and chemotherapy, 2003, Joukhadar, Christian et. al.
Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection.
score: 1.058659, Antimicrobial agents and chemotherapy, 2001, de Lalla, F et. al.
An atom counting strategy towards analyzing the biological activity of sex hormones
score: 1.0584963, European Journal of Medicinal Chemistry, 2007, Roy, D.R. et. al.
Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance.
score: 1.0584366, Antimicrobial agents and chemotherapy, 2006, Miyazaki, Taiga et. al.
Formation of spiroiminodihydantoin nucleoside from 8-oxo-7,8-dihydro-2′-deoxyguanosine by nitric oxide under aerobic conditions
score: 1.0584267, Bioorganic & Medicinal Chemistry Letters, 2009, Suzuki, Toshinori
Prolonged antimicrobial activity of a catheter containing chlorhexidine-silver sulfadiazine extends protection against catheter infections in vivo.
score: 1.0583647, Antimicrobial agents and chemotherapy, 2001, Bassetti, S; Hu, J; D'Agostino, R B; Sherertz, R J
Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis.
score: 1.0583364, Antimicrobial agents and chemotherapy, 2004, Hernandez, Steve et. al.
Ex vivo pharmacodynamics of amoxicillin-clavulanate against beta-lactamase-producing Escherichia coli in a yucatan miniature pig model that mimics human pharmacokinetics.
score: 1.0582791, Antimicrobial agents and chemotherapy, 2002, Bronner, Stéphane et. al.
Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates.
score: 1.0582479, Antimicrobial agents and chemotherapy, 2005, Löfmark, Sonja et. al.
Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments.
score: 1.0581833, Antimicrobial agents and chemotherapy, 2006, Clancy, Cornelius J et. al.
Protein oligomerization: How and why
score: 1.0581773, Bioorganic & Medicinal Chemistry, 2005, Ali, Mayssam H.; Imperiali, Barbara
Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase.
score: 1.0581002, Antimicrobial agents and chemotherapy, 2005, Frankel, Fernando A et. al.
Validation of the rapid fluorescent focus inhibition test for rabies virus-neutralizing antibodies in clinical samples.
score: 1.0580927, Antimicrobial agents and chemotherapy, 2012, Kostense, Stefan et. al.
Quantitative structure-activity relationships studies of CCR5 inhibitors and toxicity of aromatic compounds using gene expression programming
score: 1.0580908, European Journal of Medicinal Chemistry, 2010, Shi, Weimin; Zhang, Xiaoya; Shen, Qi
Expression of N-terminal Cys-protein fragments using an intein refolding strategy
score: 1.0580891, Bioorganic & Medicinal Chemistry, 2006, Hackenberger, Christian P.R. et. al.
Effects of lipid-based oral formulations on plasma and tissue amphotericin B concentrations and renal toxicity in male rats.
score: 1.0580039, Antimicrobial agents and chemotherapy, 2003, Risovic, Verica et. al.
Synthesis by microwave irradiation and binding properties of novel 5-HT 1A receptor ligands
score: 1.0579857, European Journal of Medicinal Chemistry, 2001, Caliendo, Giuseppe et. al.
A novel approach to predict a toxicological property of aromatic compounds in the Tetrahymena pyriformis
score: 1.0579811, Bioorganic & Medicinal Chemistry, 2004, González, Maykel Pérez et. al.
Absolute bioavailability and intracellular pharmacokinetics of azithromycin in patients with cystic fibrosis.
score: 1.0579695, Antimicrobial agents and chemotherapy, 2005, Beringer, Paul et. al.
Structure-Related Inhibitory Activity of Oleanolic Acid Glycosides on Gastric Emptying in Mice
score: 1.0579591, Bioorganic & Medicinal Chemistry, 1999, Matsuda, Hisashi et. al.
High genetic diversity of ciprofloxacin-nonsusceptible isolates of Streptococcus pneumoniae in Poland.
score: 1.0579576, Antimicrobial agents and chemotherapy, 2005, Sadowy, Ewa et. al.
Some O, O′, O″, O‴-di/tetra aryldithioimidophonate transition metal complexes derived from catechol and bisphenol-A as antibacterial and antifungal agents
score: 1.0579206, European Journal of Medicinal Chemistry, 2009, Kumar, Vikrant; Ahamad, Tansir; Nishat, N.
Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin.
score: 1.0579035, Antimicrobial agents and chemotherapy, 2002, van Duin, David; Casadevall, Arturo; Nosanchuk, Joshua D
Population pharmacokinetics of daptomycin.
score: 1.0578964, Antimicrobial agents and chemotherapy, 2004, Dvorchik, Barry et. al.
Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, Michigan.
score: 1.0578916, Antimicrobial agents and chemotherapy, 2011, Marchaim, Dror et. al.
Stability and compatibility of ceftazidime administered by continuous infusion to intensive care patients.
score: 1.057815, Antimicrobial agents and chemotherapy, 2001, Servais, H; Tulkens, P M
Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation
score: 1.0578137, Bioorganic & Medicinal Chemistry, 2012, Wolf, Antje et. al.
Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation
score: 1.0578137, Bioorganic & Medicinal Chemistry, 2012, Wolf, Antje et. al.
Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation
score: 1.0578137, Bioorganic & Medicinal Chemistry, 2012, Wolf, Antje et. al.
Type V staphylococcal cassette chromosome mec in community staphylococci from Australia.
score: 1.0577973, Antimicrobial agents and chemotherapy, 2005, O'Brien, F G et. al.
A new linker for glucuronylated anticancer prodrugs
score: 1.057689, Bioorganic & Medicinal Chemistry, 2004, Rivault, Freddy et. al.
Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations.
score: 1.0576863, Antimicrobial agents and chemotherapy, 2005, Wiuff, C et. al.
Mefloquine is active in vitro and in vivo against Mycobacterium avium complex.
score: 1.0576756, Antimicrobial agents and chemotherapy, 1999, Bermudez, L E et. al.
Treatment of yellow fever virus with an adenovirus-vectored interferon, DEF201, in a hamster model.
score: 1.0576314, Antimicrobial agents and chemotherapy, 2011, Julander, Justin G et. al.
Correlation of the virological response to short-term maraviroc monotherapy with standard and deep-sequencing-based genotypic tropism prediction methods.
score: 1.0576281, Antimicrobial agents and chemotherapy, 2012, Gonzalez-Serna, A et. al.
A Pyridone Analogue of Traditional Cannabinoids. A New Class of Selective Ligands for the CB 2 Receptor
score: 1.0576241, Bioorganic & Medicinal Chemistry, 2001, Huffman, John W et. al.
Inhibition of secretion of interleukin-1alpha and tumor necrosis factor alpha by the ketolide antibiotic telithromycin.
score: 1.057583, Antimicrobial agents and chemotherapy, 2002, Araujo, Fausto G; Slifer, Teri L; Remington, Jack S
Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection Model.
score: 1.0575665, Antimicrobial agents and chemotherapy, 2002, Kutlin, Andrei; Roblin, Patricia M; Hammerschlag, Margaret R
2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor
score: 1.0575604, Bioorganic & Medicinal Chemistry, 2000, Scott, Malcolm K et. al.
Chromosomal mutations responsible for fluoroquinolone resistance in Ureaplasma species in the United States.
score: 1.0575127, Antimicrobial agents and chemotherapy, 2012, Xiao, Li et. al.
Genetic basis of tetracycline and minocycline resistance in potentially probiotic Lactobacillus plantarum strain CCUG 43738.
score: 1.0574705, Antimicrobial agents and chemotherapy, 2006, Huys, Geert; D'Haene, Klaas; Swings, Jean
Quinolones sensitize gram-negative bacteria to antimicrobial peptides.
score: 1.0574342, Antimicrobial agents and chemotherapy, 2006, Campos, Miguel A; Morey, Pau; Bengoechea, José A
Subpopulations of Helicobacter pylori are responsible for discrepancies in the outcome of nitroimidazole susceptibility testing.
score: 1.0573424, Antimicrobial agents and chemotherapy, 1999, van der Wouden, E J et. al.
Molecular correlates of high-level antifolate resistance in Rwandan children with Plasmodium falciparum malaria.
score: 1.05731, Antimicrobial agents and chemotherapy, 2010, Karema, Corine et. al.
Comparative pharmacodynamics and antimutant potentials of doripenem and imipenem with ciprofloxacin-resistant Pseudomonas aeruginosa in an in vitro model.
score: 1.0572874, Antimicrobial agents and chemotherapy, 2012, Firsov, Alexander A et. al.
Solid-phase synthesis of α-substituted 3-bisarylthio N-Hydroxy propionamides as Specific MMP Inhibitors
score: 1.0572647, Bioorganic & Medicinal Chemistry, 2002, Chollet, Anne-Marie et. al.
The enigma of coproporphyrinogen oxidase: How does this unusual enzyme carry out oxidative decarboxylations to afford vinyl groups?
score: 1.0572534, Bioorganic & Medicinal Chemistry Letters, 2005, Lash, Timothy D.
New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human κ opioid receptors
score: 1.0571999, Bioorganic & Medicinal Chemistry, 2005, Lee, David Y.W. et. al.
In Vitro Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335.
score: 1.057125, Antimicrobial agents and chemotherapy, 2012, Lagacé, Lisette et. al.
Synthesis of 2-substituted β-cyclodextrin derivatives with a hydrolytic activity against the organophosphorylester paraoxon
score: 1.0570828, European Journal of Medicinal Chemistry, 2005, Masurier, Nicolas et. al.
Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.
score: 1.0570781, Antimicrobial agents and chemotherapy, 2011, Lu, Ping et. al.
Reverse engineering antibiotic sensitivity in a multidrug-resistant Pseudomonas aeruginosa isolate.
score: 1.0570636, Antimicrobial agents and chemotherapy, 2006, Struble, Julie M; Gill, Ryan T
A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients.
score: 1.0570286, Antimicrobial agents and chemotherapy, 2012, Smythe, Wynand et. al.
Real-time monitoring of bacterial infection in vivo: development of bioluminescent staphylococcal foreign-body and deep-thigh-wound mouse infection models.
score: 1.0570278, Antimicrobial agents and chemotherapy, 2003, Kuklin, Nelly A et. al.
Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection.
score: 1.0570097, Antimicrobial agents and chemotherapy, 2004, Pammit, Michael A et. al.
Pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate in humans.
score: 1.0569698, Antimicrobial agents and chemotherapy, 2002, Bekersky, Ihor et. al.
Impact of trimethoprim-sulfamethoxazole prophylaxis on etiology and susceptibilities of pathogens causing human immunodeficiency virus-associated bacteremia.
score: 1.0569377, Antimicrobial agents and chemotherapy, 2002, Wininger, David A; Fass, Robert J
Inhibition of hepatitis C virus replication by antimonial compounds.
score: 1.0569286, Antimicrobial agents and chemotherapy, 2005, Hwang, Der-Ren et. al.
Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes.
score: 1.0569267, Antimicrobial agents and chemotherapy, 2003, Bernstein, D I et. al.
CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.
score: 1.0569243, Antimicrobial agents and chemotherapy, 2004, Miriagou, V et. al.
A module located at a chromosomal integration hot spot is responsible for the multidrug resistance of a reference strain from Escherichia coli clonal group A.
score: 1.056918, Antimicrobial agents and chemotherapy, 2009, Lescat, Mathilde et. al.
Synthesis and evaluation of photolabile insulin prodrugs
score: 1.056917, Bioorganic & Medicinal Chemistry Letters, 2005, Li, Lian-Sheng et. al.
Importance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance.
score: 1.0569079, Antimicrobial agents and chemotherapy, 2012, Köser, Claudio U et. al.
Efficacy, Safety, and Pharmacokinetics of Intravenous Peramivir in Children with 2009 Pandemic H1N1 Influenza A Virus Infection.
score: 1.0569061, Antimicrobial agents and chemotherapy, 2012, Sugaya, Norio et. al.
Health care-associated pneumonia and community-acquired pneumonia: a single-center experience.
score: 1.0569053, Antimicrobial agents and chemotherapy, 2007, Micek, Scott T et. al.
A convenient synthesis of ( Z)-4-hydroxy- N-desmethyltamoxifen (endoxifen)
score: 1.0568993, Bioorganic & Medicinal Chemistry Letters, 2010, Fauq, Abdul H.; Maharvi, Ghulam M.; Sinha, Dola
Functional and structural characterization of the genetic environment of an extended-spectrum beta-lactamase blaVEB gene from a Pseudomonas aeruginosa isolate obtained in India.
score: 1.0567887, Antimicrobial agents and chemotherapy, 2004, Aubert, Daniel et. al.
Cloning of a cation efflux pump gene associated with chlorhexidine resistance in Klebsiella pneumoniae.
score: 1.0567504, Antimicrobial agents and chemotherapy, 2002, Fang, Chi-Tai et. al.
Synthesis and evaluation of a radioiodinated bladder cancer specific peptide
score: 1.0567309, Bioorganic & Medicinal Chemistry, 2012, Ha, Yeong Su et. al.
Synthesis and evaluation of a radioiodinated bladder cancer specific peptide
score: 1.0567309, Bioorganic & Medicinal Chemistry, 2012, Ha, Yeong Su et. al.
Synthesis and evaluation of a radioiodinated bladder cancer specific peptide
score: 1.0567309, Bioorganic & Medicinal Chemistry, 2012, Ha, Yeong Su et. al.
Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.
score: 1.0567168, Antimicrobial agents and chemotherapy, 2001, Ramaswamy, M; Peteherych, K D; Kennedy, A L; Wasan, K M
Distribution and antimicrobial activity of ciprofloxacin in human soft tissues.
score: 1.0567103, Antimicrobial agents and chemotherapy, 1999, Brunner, M et. al.
Enhanced RNA binding of dimerized aminoglycosides
score: 1.0566077, Bioorganic & Medicinal Chemistry, 1999, Michael, Katja; Wang, Hai; Tor, Yitzhak
Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro.
score: 1.0565067, Antimicrobial agents and chemotherapy, 2000, Cottagnoud, P et. al.
Comparative in vitro susceptibilities and bactericidal activities of investigational fluoroquinolone ABT-492 and other antimicrobial agents against human mycoplasmas and ureaplasmas.
score: 1.056492, Antimicrobial agents and chemotherapy, 2003, Waites, Ken B; Crabb, Donna M; Duffy, Lynn B
Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections.
score: 1.0563865, Antimicrobial agents and chemotherapy, 2011, Huang, Liyi et. al.
Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors
score: 1.0563807, European Journal of Medicinal Chemistry, 2012, Navarrete-Vazquez, Gabriel et. al.
A quantitative structure–activity relationship study on some HIV-1 protease inhibitors using molecular connectivity index
score: 1.0563417, Bioorganic & Medicinal Chemistry, 2001, Gayathri, P.; Pande, V.; Sivakumar, R.; Gupta, S.P.
In vitro development of resistance to telithromycin (HMR 3647), four macrolides, clindamycin, and pristinamycin in Streptococcus pneumoniae.
score: 1.0563035, Antimicrobial agents and chemotherapy, 2000, Davies, T A; Dewasse, B E; Jacobs, M R; Appelbaum, P C
First identification of blaIMI-1 in an Enterobacter cloacae clinical isolate from France.
score: 1.0561714, Antimicrobial agents and chemotherapy, 2012, Naas, Thierry et. al.
Photochemical N-demethylation of alkaloids
score: 1.0561622, Bioorganic & Medicinal Chemistry Letters, 2001, Ripper, Justin A.; Tiekink, Edward R.T.; Scammells, Peter J.
Is stavudine triphosphate a natural metabolite of zidovudine?
score: 1.0561532, Antimicrobial agents and chemotherapy, 2006, Benech, Henri et. al.
Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS.
score: 1.0559785, Antimicrobial agents and chemotherapy, 2010, Fernández, Lucía et. al.
Use of anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads for capture of respiratory syncytial virus
score: 1.0558924, Bioorganic & Medicinal Chemistry Letters, 2009, Sakudo, Akikazu et. al.
Straightforward Syntheses of Furanomycin Derivatives and their Biological Evaluation
score: 1.0558378, Bioorganic & Medicinal Chemistry, 2002, Kazmaier, Uli et. al.
Antibiotic resistance in Listeria spp.
score: 1.0558309, Antimicrobial agents and chemotherapy, 1999, Charpentier, E; Courvalin, P
Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A).
score: 1.0557461, Antimicrobial agents and chemotherapy, 2002, Schwarz, Stefan; Kehrenberg, Corinna; Ojo, Kayode K
Cloning of a Chryseobacterium (Flavobacterium) meningosepticum chromosomal gene (blaA(CME)) encoding an extended-spectrum class A beta-lactamase related to the Bacteroides cephalosporinases and the VEB-1 and PER beta-lactamases.
score: 1.0557088, Antimicrobial agents and chemotherapy, 1999, Rossolini, G M et. al.
Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-Cyclopropylfurano[2,3- e]indoline ( seco-iso-CFI) and seco-Cyclopropyltetrahydrofurano[2,3- f]quinoline ( seco-CFQ) analogues
score: 1.0556656, Bioorganic & Medicinal Chemistry, 2002, Howard, Tiffany T. et. al.
Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter.
score: 1.0556564, Antimicrobial agents and chemotherapy, 2004, Michot, Jean-Michel et. al.
Relationship between in vitro activities of amphotericin B and flucytosine and pH for clinical yeast and mold isolates.
score: 1.0556194, Antimicrobial agents and chemotherapy, 2005, te Dorsthorst, D T A et. al.
Fitness cost due to mutations in the 16S rRNA associated with spectinomycin resistance in Chlamydia psittaci 6BC.
score: 1.0556112, Antimicrobial agents and chemotherapy, 2005, Binet, Rachel; Maurelli, Anthony T
A small amount of fat does not affect piperaquine exposure in patients with malaria.
score: 1.0556092, Antimicrobial agents and chemotherapy, 2011, Annerberg, Anna et. al.
Efficacy of colistin versus beta-lactams, aminoglycosides, and rifampin as monotherapy in a mouse model of pneumonia caused by multiresistant Acinetobacter baumannii.
score: 1.0556016, Antimicrobial agents and chemotherapy, 2002, Montero, A et. al.
Drug evaluation of concurrent Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium complex infections in a rat model.
score: 1.0555831, Antimicrobial agents and chemotherapy, 1998, Brun-Pascaud, M et. al.
bla(SHV) Genes in Klebsiella pneumoniae: different allele distributions are associated with different promoters within individual isolates.
score: 1.055559, Antimicrobial agents and chemotherapy, 2005, Hammond, David S et. al.
New high affinity H 3 receptor agonists without a basic side chain
score: 1.0555356, Bioorganic & Medicinal Chemistry, 2005, Kitbunnadaj, Ruengwit et. al.
A Phe389Leu substitution in ergA confers terbinafine resistance in Aspergillus fumigatus.
score: 1.0555347, Antimicrobial agents and chemotherapy, 2006, Rocha, E M F et. al.
In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts.
score: 1.0554963, Antimicrobial agents and chemotherapy, 2006, Sabatelli, F et. al.
Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.
score: 1.0554896, Antimicrobial agents and chemotherapy, 2004, Hofman, Michael J et. al.
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine- N 1-acetyltransferase
score: 1.0554066, Bioorganic & Medicinal Chemistry, 1996, Wu, Ronghui et. al.
Multiplex asymmetric PCR-based oligonucleotide microarray for detection of drug resistance genes containing single mutations in Enterobacteriaceae.
score: 1.0553903, Antimicrobial agents and chemotherapy, 2007, Zhu, Ling-Xiang et. al.
Vancomycin AUC24/MIC ratio in patients with complicated bacteremia and infective endocarditis due to methicillin-resistant Staphylococcus aureus and its association with attributable mortality during hospitalization.
score: 1.0553874, Antimicrobial agents and chemotherapy, 2012, Brown, Jack; Brown, Kristen; Forrest, Alan
Carbapenem-resistant isolates of Klebsiella pneumoniae in China and detection of a conjugative plasmid (blaKPC-2 plus qnrB4) and a blaIMP-4 gene.
score: 1.0552564, Antimicrobial agents and chemotherapy, 2008, Mendes, Rodrigo E et. al.
QSAR Studies on acylated histamine derivatives
score: 1.0552504, Bioorganic & Medicinal Chemistry, 2001, Agrawal, Vijay K; Khadikar, Padmakar V
Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain.
score: 1.0552276, Antimicrobial agents and chemotherapy, 2011, Hidalgo, Álvaro et. al.
Multicenter study in Taiwan of the in vitro activities of nemonoxacin, tigecycline, doripenem, and other antimicrobial agents against clinical isolates of various Nocardia species.
score: 1.055155, Antimicrobial agents and chemotherapy, 2011, Lai, Chih-Cheng et. al.
Activity of voriconazole, a new triazole, combined with neutrophils or monocytes against Candida albicans: effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
score: 1.0551443, Antimicrobial agents and chemotherapy, 1998, Vora, S; Purimetla, N; Brummer, E; Stevens, D A
Paclitaxel arrests growth of intracellular Toxoplasma gondii.
score: 1.0551249, Antimicrobial agents and chemotherapy, 1998, Estes, R; Vogel, N; Mack, D; McLeod, R
In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis.
score: 1.0549566, Antimicrobial agents and chemotherapy, 2006, Hoeben, Barbara J et. al.
Genome Sequencing of a Neisseria gonorrhoeae Isolate of a Successful International Clone with Decreased Susceptibility and Resistance to Extended-Spectrum Cephalosporins.
score: 1.0548893, Antimicrobial agents and chemotherapy, 2012, Hess, David et. al.
Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants
score: 1.054858, Bioorganic & Medicinal Chemistry, 2004, Bhandari, Kalpana; Srivastava, Shipra; Shankar, Girija
The putative lactococcal extracytoplasmic function anti-sigma factor llmg2447 determines resistance to the cell wall-active bacteriocin lcn972.
score: 1.0548394, Antimicrobial agents and chemotherapy, 2012, Roces, Clara et. al.
Identification of Peptides Derived from the Human Antimicrobial Peptide LL-37 Active against Biofilms Formed by Pseudomonas aeruginosa Using a Library of Truncated Fragments.
score: 1.0547955, Antimicrobial agents and chemotherapy, 2012, Nagant, C et. al.
In vitro and in vivo antibacterial activities of CS-834, a new oral carbapenem.
score: 1.0547665, Antimicrobial agents and chemotherapy, 1998, Yamaguchi, K et. al.
Lacticin Q-mediated selective toxicity depending on physicochemical features of membrane components.
score: 1.0547417, Antimicrobial agents and chemotherapy, 2011, Yoneyama, Fuminori et. al.
Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548.
score: 1.0547373, Antimicrobial agents and chemotherapy, 2005, Galimand, M; Sabtcheva, S; Courvalin, P; Lambert, T
Effect of porins and plasmid-mediated AmpC beta-lactamases on the efficacy of beta-lactams in rat pneumonia caused by Klebsiella pneumoniae.
score: 1.0547222, Antimicrobial agents and chemotherapy, 2006, Padilla, Emma et. al.
Efflux pump Lde is associated with fluoroquinolone resistance in Listeria monocytogenes.
score: 1.0547102, Antimicrobial agents and chemotherapy, 2003, Godreuil, Sylvain et. al.
DNA binding, antioxidant and antimicrobial activities of homo- and heteronuclear copper(II) and nickel(II) complexes with new oxime-type ligands
score: 1.0546726, European Journal of Medicinal Chemistry, 2010, Colak, Ahmet et. al.
Effect of voriconazole combined with micafungin against Candida, Aspergillus, and Scedosporium spp. and Fusarium solani.
score: 1.0546365, Antimicrobial agents and chemotherapy, 2005, Heyn, Kathrin et. al.
Horizontal transfer of parC and gyrA in fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.
score: 1.0546252, Antimicrobial agents and chemotherapy, 2000, Ferrándiz, M J; Fenoll, A; Liñares, J; De La Campa, A G
Metal ion CHElate-aSSisted LIGAtion (CHESS LIGA) for SNP detection on microarrays
score: 1.0546227, Bioorganic & Medicinal Chemistry Letters, 2009, Hien, Le Thi; Oretskaya, Tatiana S.; Zatsepin, Timofei S.
Technetium-99m-labeled ceftizoxime loaded long-circulating and pH-sensitive liposomes used to identify osteomyelitis
score: 1.0545959, Bioorganic & Medicinal Chemistry Letters, 2012, Ferreira, Soraya Maria Zandim Maciel Dias et. al.
Technetium-99m-labeled ceftizoxime loaded long-circulating and pH-sensitive liposomes used to identify osteomyelitis
score: 1.0545959, Bioorganic & Medicinal Chemistry Letters, 2012, Ferreira, Soraya Maria Zandim Maciel Dias et. al.
On the mechanism of isomerization of all- trans-retinol esters to 11- cis-retinol in retinal pigment epithelial cells: 11-Fluoro-all- trans-retinol as substrate/inhibitor in the visual cycle
score: 1.0545892, Bioorganic & Medicinal Chemistry, 2005, Fishkin, Nathan et. al.
Synthesis and QSAR studies of novel 1-substituted-2-aminobenzimidazoles derivatives
score: 1.054558, European Journal of Medicinal Chemistry, 2006, Guida, Xuan; Jianhua, Han; Xiaomin, Li
Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B.
score: 1.0545186, Antimicrobial agents and chemotherapy, 1999, Denning, D W; Warn, P
Impact of dose de-escalation and escalation on daptomycin's pharmacodynamics against clinical methicillin-resistant Staphylococcus aureus isolates in an in vitro model.
score: 1.054466, Antimicrobial agents and chemotherapy, 2011, Vidaillac, Celine; Steed, Molly E; Rybak, Michael J
Novel chimeric genotype 1b/2a hepatitis C virus suitable for high-throughput screening.
score: 1.0544594, Antimicrobial agents and chemotherapy, 2008, Zhang, Yingjia; Weady, Peter; Duggal, Rohit; Hao, Weidong
Prevalence of antimicrobial-resistant pathogens in middle ear fluid: multinational study of 917 children with acute otitis media.
score: 1.0544551, Antimicrobial agents and chemotherapy, 1998, Jacobs, M R; Dagan, R; Appelbaum, P C; Burch, D J
Identification of the Haemophilus influenzae tolC gene by susceptibility profiles of insertionally inactivated efflux pump mutants.
score: 1.0544252, Antimicrobial agents and chemotherapy, 2004, Trepod, Catherine M; Mott, John E
Independent behavior of commensal flora for carriage of fluoroquinolone-resistant bacteria in patients at admission.
score: 1.0543464, Antimicrobial agents and chemotherapy, 2010, de Lastours, Victoire et. al.
Inhibitory action of a truncated derivative of the amphibian skin peptide dermaseptin s3 on Saccharomyces cerevisiae.
score: 1.0543289, Antimicrobial agents and chemotherapy, 1998, Coote, P J et. al.
Effect of trovafloxacin on production of cytokines by human monocytes.
score: 1.0543212, Antimicrobial agents and chemotherapy, 1998, Khan, A A; Slifer, T R; Remington, J S
Chemiosmotic mechanism of antimicrobial activity of Ag(+) in Vibrio cholerae.
score: 1.0542596, Antimicrobial agents and chemotherapy, 2002, Dibrov, Pavel et. al.
Influence of a pulmonary surfactant on the in vitro activity of tobramycin against Pseudomonas aeruginosa.
score: 1.0542325, Antimicrobial agents and chemotherapy, 1999, Caldwell, E J; Piper, D S
Potential prodrugs of non-steroidal anti-inflammatory agents for targeted drug delivery to the CNS
score: 1.0542057, European Journal of Medicinal Chemistry, 2004, Perioli, Luana et. al.
In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection.
score: 1.0541739, Antimicrobial agents and chemotherapy, 2004, Steinbach, William J et. al.
Diverse mobilized class 1 integrons are common in the chromosomes of pathogenic Pseudomonas aeruginosa clinical isolates.
score: 1.0541697, Antimicrobial agents and chemotherapy, 2012, Martinez, Elena et. al.
Sequence-Selective Peptide Detection by Small Synthetic Chemosensors Selected from an Encoded Combinatorial Chemosensor Library
score: 1.0540895, Bioorganic & Medicinal Chemistry Letters, 2001, Iorio, Edward James et. al.
Population pharmacokinetics of voriconazole in adults.
score: 1.0540798, Antimicrobial agents and chemotherapy, 2012, Hope, William W
Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.
score: 1.0540744, Antimicrobial agents and chemotherapy, 2002, Dutta, Ireena; Reynolds, Peter E
Postantibiotic effects of garenoxacin (BMS-284756) against 12 gram-positive or -negative organisms.
score: 1.0540488, Antimicrobial agents and chemotherapy, 2003, Pankuch, G A; Jacobs, M R; Appelbaum, P C
Synthesis and antibacterial activity of various substituted s-triazines
score: 1.0540045, European Journal of Medicinal Chemistry, 2006, Srinivas, K. et. al.
Pharmacokinetics of nelfinavir and efavirenz in antiretroviral-naive, human immunodeficiency virus-infected subjects when administered alone or in combination with nucleoside analog reverse transcriptase inhibitors.
score: 1.054003, Antimicrobial agents and chemotherapy, 2005, Smith, Patrick F et. al.
Animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration.
score: 1.0538829, Antimicrobial agents and chemotherapy, 2001, Aviles, P et. al.
Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile.
score: 1.053848, Antimicrobial agents and chemotherapy, 2004, Kaldalu, Niilo; Mei, Rui; Lewis, Kim
Pharmacokinetics of intraperitoneal and intravenous fosfomycin in automated peritoneal dialysis patients without peritonitis.
score: 1.0538076, Antimicrobial agents and chemotherapy, 2012, Tobudic, Selma et. al.
Comparative pharmacokinetics of intramuscular artesunate and artemether in patients with severe falciparum malaria.
score: 1.0537558, Antimicrobial agents and chemotherapy, 2004, Hien, T T et. al.
Global challenge of antibiotic-resistant Treponema pallidum.
score: 1.0537452, Antimicrobial agents and chemotherapy, 2010, Stamm, Lola V
Corrigendum to “A flexizyme that selectively charges amino acids activated by a water-friendly leaving group” [Bioorg. Med. Chem. Lett. 19 (2009) 3892]
score: 1.053696, Bioorganic & Medicinal Chemistry Letters, 2010, Niwa, Nobuyoshi et. al.
Introduction of ertapenem into a hospital formulary: effect on antimicrobial usage and improved in vitro susceptibility of Pseudomonas aeruginosa.
score: 1.0536948, Antimicrobial agents and chemotherapy, 2009, Goldstein, Ellie J C et. al.
Pulmonary damage and bacterial load in assessment of the efficacy of simulated human treatment-like amoxicillin (2,000 milligrams) therapy of experimental pneumococcal pneumonia caused by strains for which amoxicillin MICs differ.
score: 1.0535935, Antimicrobial agents and chemotherapy, 2005, Gracia, Matilde et. al.
Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression
score: 1.0535478, Bioorganic & Medicinal Chemistry Letters, 2005, Yeh, Li-An et. al.
In vivo activity of HSR-903, a new fluoroquinolone, against respiratory pathogens.
score: 1.053447, Antimicrobial agents and chemotherapy, 1998, Yoshizumi, S; Domon, H; Miyazaki, S; Yamaguchi, K
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
score: 1.0534167, Antimicrobial agents and chemotherapy, 2006, Tumbarello, Mario et. al.
Antimicrobial susceptibility to azithromycin among Salmonella enterica isolates from the United States.
score: 1.0533854, Antimicrobial agents and chemotherapy, 2011, Sjölund-Karlsson, Maria et. al.
Sphingolipids as coenzymes in anion transfer and tumor death
score: 1.0533845, Bioorganic & Medicinal Chemistry, 2004, Radin, Norman S.
Sensititre YeastOne caspofungin susceptibility testing of Candida clinical isolates: correlation with results of NCCLS M27-A2 multicenter study.
score: 1.0533652, Antimicrobial agents and chemotherapy, 2005, Cantón, Emilia et. al.
Phage display screening against a set of targets to establish peptide-based sugar mimetics and molecular docking to predict binding site
score: 1.0533614, Bioorganic & Medicinal Chemistry, 2009, Yu, Limin et. al.
Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients.
score: 1.0533551, Antimicrobial agents and chemotherapy, 1999, Lopez-Ribot, J L et. al.
Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme
score: 1.0533496, Bioorganic & Medicinal Chemistry, 2005, Andrade, Marcelo T. et. al.
Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections.
score: 1.0532243, Antimicrobial agents and chemotherapy, 2004, Kern, Earl R et. al.
A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms.
score: 1.0532219, Antimicrobial agents and chemotherapy, 2000, Brooun, A; Liu, S; Lewis, K
Synthetic approaches to peptides containing the l-Gln- l-Val-D( S)-Dmt motif
score: 1.0531759, Bioorganic & Medicinal Chemistry, 2007, Suaifan, Ghadeer A.R.Y. et. al.
Synthesis and antitumor activities of novel 5-deazaflavin-sialic acid conjugate molecules
score: 1.0531328, Bioorganic & Medicinal Chemistry, 2000, Ikeuchi, Yoshihiro et. al.
Evaluation of once-weekly therapy for tuberculosis using isoniazid plus rifamycins in the mouse aerosol infection model.
score: 1.0531009, Antimicrobial agents and chemotherapy, 1998, Brooks, J V; Orme, I M
Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E).
score: 1.053093, Antimicrobial agents and chemotherapy, 2005, Klaassen, Corné H W; Mouton, Johan W
Influence of antituberculosis drug resistance and Mycobacterium tuberculosis lineage on outcome in HIV-associated tuberculous meningitis.
score: 1.0530706, Antimicrobial agents and chemotherapy, 2012, Tho, Dau Quang et. al.
Analysis of structural features of bis-quaternary ammonium antimicrobial agents 4,4′-(α,ω-Polymethylenedithio)bis (1-alkylpyridinium iodide)s using computational simulation
score: 1.0530366, Bioorganic & Medicinal Chemistry, 2003, Ohkura, Kazuto et. al.
Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors
score: 1.0530122, Bioorganic & Medicinal Chemistry, 2005, Kassiou, Michael et. al.
Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtCl 2( R-dimepyrr)] ( R-dimepyrr = N-dimethyl-2( R)-aminomethylpyrrolidine)
score: 1.0530055, European Journal of Medicinal Chemistry, 2009, Diakos, Connie I. et. al.
A protein kinase signal-responsive gene carrier modified RGD peptide
score: 1.0530002, Bioorganic & Medicinal Chemistry Letters, 2006, Oishi, Jun et. al.
Temporal appearance of plasmid-mediated quinolone resistance genes.
score: 1.0529878, Antimicrobial agents and chemotherapy, 2009, Jacoby, George A et. al.
Correlation of antibacterial activity of some N-[5-(2-furanyl)-2-methyl-4-oxo-4 H-thieno[2,3- d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3 H-thieno[2,3- d]pyrimidin-4-ones with topological indices using Hansch analysis
score: 1.0529583, Bioorganic & Medicinal Chemistry Letters, 2006, Narasimhan, Balasubramanian et. al.
Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas.
score: 1.0529505, Antimicrobial agents and chemotherapy, 2005, Chavez-Bueno, Susana et. al.
Rapid Identification of International Multidrug-Resistant Pseudomonas aeruginosa Clones by Multiple-Locus Variable Number of Tandem Repeats Analysis and Investigation of Their Susceptibility to Lytic Bacteriophages.
score: 1.052927, Antimicrobial agents and chemotherapy, 2012, Larché, Jérôme et. al.
Population-based study of the increased incidence of skin and soft tissue infections and associated antimicrobial use.
score: 1.0528523, Antimicrobial agents and chemotherapy, 2012, Marra, Fawziah et. al.
Diversity of Tn1546 and its role in the dissemination of vancomycin-resistant enterococci in Portugal.
score: 1.052775, Antimicrobial agents and chemotherapy, 2008, Novais, Carla et. al.
Characterization of OXA-25, OXA-26, and OXA-27, molecular class D beta-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii.
score: 1.0527238, Antimicrobial agents and chemotherapy, 2001, Afzal-Shah, M; Woodford, N; Livermore, D M
Synthesis and antimicrobial activities of silver(I) 3-(substituted phenyl)sulfanylpropenoates
score: 1.0526871, European Journal of Medicinal Chemistry, 2008, Barreiro, Elena et. al.
Design, synthesis, and biological evaluation of anti-HIV double-drugs
score: 1.0526526, Bioorganic & Medicinal Chemistry, 2001, Matsumoto, Hikaru et. al.
Exposure to metronidazole in vivo readily induces resistance in Helicobacter pylori and reduces the efficacy of eradication therapy in mice.
score: 1.0526273, Antimicrobial agents and chemotherapy, 1999, Jenks, P J; Labigne, A; Ferrero, R L
Emergence of multidrug-resistant Salmonella enterica serovar typhi in Korea.
score: 1.0526056, Antimicrobial agents and chemotherapy, 2004, Lee, Kyungwon et. al.
QSAR study on bioconcentration factor (BCF) of polyhalogented biphenyls using the PI index
score: 1.0526013, Bioorganic & Medicinal Chemistry, 2003, Khadikar, Padmakar V. et. al.
Flow cytometric monitoring of antibiotic-induced injury in Escherichia coli using cell-impermeant fluorescent probes.
score: 1.0525844, Antimicrobial agents and chemotherapy, 2000, Mortimer, F C; Mason, D J; Gant, V A
Emergence of antibiotic-resistant Pseudomonas aeruginosa: comparison of risks associated with different antipseudomonal agents.
score: 1.0525579, Antimicrobial agents and chemotherapy, 1999, Carmeli, Y; Troillet, N; Eliopoulos, G M; Samore, M H
Damage of the bacterial cell envelope by antimicrobial peptides gramicidin S and PGLa as revealed by transmission and scanning electron microscopy.
score: 1.0524657, Antimicrobial agents and chemotherapy, 2010, Hartmann, Mareike et. al.
Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood.
score: 1.0524244, Antimicrobial agents and chemotherapy, 2007, Schnitzler, Paul; Koch, Christine; Reichling, Jürgen
Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis.
score: 1.0523937, Antimicrobial agents and chemotherapy, 2012, Jeans, Adam R et. al.
Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme
score: 1.052385, European Journal of Medicinal Chemistry, 2006, Lohith, K. et. al.
The structure–bioavailability approach in antifungal agents
score: 1.0523091, European Journal of Medicinal Chemistry, 2009, Grudzień, Monika et. al.
Immunotherapy with a combination of intravenous immune globulin and p4 peptide rescues mice from postinfluenza pneumococcal pneumonia.
score: 1.0522795, Antimicrobial agents and chemotherapy, 2011, Weeks, Jenni N et. al.
Growth phase-dependent effect of clindamycin on production of exoproteins by Streptococcus pyogenes.
score: 1.0522671, Antimicrobial agents and chemotherapy, 2007, Sawai, Jun et. al.
Influence of prior exposure to zidovudine on stavudine phosphorylation in vivo and ex vivo.
score: 1.0522347, Antimicrobial agents and chemotherapy, 2001, Hoggard, P G et. al.
Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm.
score: 1.0522172, Antimicrobial agents and chemotherapy, 2012, Yu, Li-Hua et. al.
Systematic review and meta-analysis of the significance of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates.
score: 1.0521807, Antimicrobial agents and chemotherapy, 2011, van Hal, Sebastiaan J; Paterson, David L
Antibiotic susceptibility of Stenotrophomonas maltophilia in the presence of lactoferrin.
score: 1.0521259, Antimicrobial agents and chemotherapy, 2005, Qamruddin, Ahmed O; Alkawash, Mustafa A; Soothill, James S
Consumption patterns and in vitro resistance of Streptococcus pneumoniae to fluoroquinolones.
score: 1.0521256, Antimicrobial agents and chemotherapy, 2011, Simoens, Steven et. al.
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 10: identification of inhibitors for the liver microsomal acetoxycoumarin: protein transacetylase
score: 1.0521226, Bioorganic & Medicinal Chemistry, 2003, Raj, Hanumantharao G et. al.
Site-specific immobilization of proteins in a microarray using intein-mediated protein splicing
score: 1.0521169, Bioorganic & Medicinal Chemistry Letters, 2005, Girish, Aparna et. al.
A Series of Enediynes as Novel Inhibitors of Topoisomerase I
score: 1.0521121, Bioorganic & Medicinal Chemistry, 2001, Lin, Chi-Fong et. al.
Synthesis of new 2,5-Disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities
score: 1.0519857, Bioorganic & Medicinal Chemistry, 2002, Dogan, Hatice N et. al.
Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.
score: 1.0519181, Antimicrobial agents and chemotherapy, 1999, Arlet, G; Goussard, S; Courvalin, P; Philippon, A
Cloning and nucleotide sequences of the topoisomerase IV parC and parE genes of Mycoplasma hominis.
score: 1.051877, Antimicrobial agents and chemotherapy, 1998, Bébéar, C M; Charron, A; Bové, J M; Bébéar, C; Renaudin, J
Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis
score: 1.0518568, European Journal of Medicinal Chemistry, 2012, Ilić, Miloš et. al.
Aminothiazole derivatives with antidegenerative activity on cartilage
score: 1.0518081, Bioorganic & Medicinal Chemistry, 2003, Panico, Anna Maria et. al.
VIM-4 in a carbapenem-resistant strain of Pseudomonas aeruginosa isolated in Sweden.
score: 1.0518028, Antimicrobial agents and chemotherapy, 2003, Giske, Christian G; Rylander, Margareta; Kronvall, Göran
Interlaboratory comparison of agar dilution and Etest methods for determining the MICs of antibiotics used in management of Neisseria meningitidis infections.
score: 1.0517815, Antimicrobial agents and chemotherapy, 2003, Vázquez, Julio A et. al.
The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria.
score: 1.051738, Antimicrobial agents and chemotherapy, 1998, Swaney, S M; Aoki, H; Ganoza, M C; Shinabarger, D L
Increased catalytic activity of protein disulfide isomerase using aromatic thiol based redox buffers
score: 1.0517251, Bioorganic & Medicinal Chemistry Letters, 2005, Gough, Jonathan D.; Lees, Watson J.
Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.
score: 1.0515663, Antimicrobial agents and chemotherapy, 2012, Espinel-Ingroff, A et. al.
Evidence for reduction in breakpoints used to determine vancomycin susceptibility in Staphylococcus aureus.
score: 1.0515377, Antimicrobial agents and chemotherapy, 2005, Wootton, Mandy; Walsh, T R; MacGowan, A P
linckosides A and B, two new neuritogenic steroid glycosides from the okinawan starfish linckia laevigata
score: 1.0515248, Bioorganic & Medicinal Chemistry, 2002, Qi, Jianhua; Ojika, Makoto; Sakagami, Youji
Bacterial adhesion forces with substratum surfaces and the susceptibility of biofilms to antibiotics.
score: 1.0515134, Antimicrobial agents and chemotherapy, 2012, Muszanska, Agnieszka K et. al.
Cluster Analysis of the DrugBank Chemical Space Using Molecular Quantum Numbers
score: 1.0515098, Bioorganic & Medicinal Chemistry, 2012, Awale, Mahendra; Reymond, Jean-Louis
Pharmacokinetics and pharmacodynamics of cefepime in patients with various degrees of renal function.
score: 1.0514936, Antimicrobial agents and chemotherapy, 2003, Tam, Vincent H et. al.
Synthesis of α-tocohexaenol (α-T6) a fluorescent, oxidatively sensitive polyene analogue of α-tocopherol
score: 1.0514851, Bioorganic & Medicinal Chemistry, 2010, Wang, Yongsheng; Panagabko, Candace; Atkinson, Jeffrey
Structure-activity relationships of 2-Aryl-2,5-dihydropyridazino[4,3- b]indol-3(3H)-ones at the benzodiazepine receptor
score: 1.051463, Bioorganic & Medicinal Chemistry, 1996, Palluotto, F. et. al.
Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 in the woodchuck model of hepatitis B virus infection.
score: 1.0514612, Antimicrobial agents and chemotherapy, 1998, Genovesi, E V et. al.
VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.
score: 1.0514308, Antimicrobial agents and chemotherapy, 2005, Pournaras, Spyros et. al.
Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog
score: 1.0514281, Bioorganic & Medicinal Chemistry, 2013, Michelini, Flavia M. et. al.
Enzyme-catalyzed antimicrobial activation.
score: 1.0514069, Antimicrobial agents and chemotherapy, 2002, Hamilton-Miller, J M T
Electrophilicity index as a possible descriptor of biological activity
score: 1.0513786, Bioorganic & Medicinal Chemistry, 2004, Parthasarathi, R. et. al.
In vitro activities of investigational triazoles against Fusarium species: effects of inoculum size and incubation time on broth microdilution susceptibility test results.
score: 1.0513058, Antimicrobial agents and chemotherapy, 2002, Paphitou, Niki I et. al.
Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997).
score: 1.0512547, Antimicrobial agents and chemotherapy, 1998, Pfaller, M A; Jones, R N; Doern, G V; Kugler, K
Incidence of class 1 and 2 integrases in clinical and commensal bacteria from livestock, companion animals, and exotics.
score: 1.0512479, Antimicrobial agents and chemotherapy, 2001, Goldstein, C et. al.
Influence of assay methodology on the measurement of free serum ceftriaxone concentrations.
score: 1.0511883, Antimicrobial agents and chemotherapy, 1998, Kohlhepp, S J; Gilbert, D N; Leggett, J E
On the formation of steroidal amidoesters of 4-[N,N-bis(2-chloroethyl)amino]benzoic acid and their cytotoxic activity # # Dedicated to the memory of Professor Panayotis Catsoulacos
score: 1.0511447, European Journal of Medicinal Chemistry, 1999, Camoutsis, C; Sambani, C; Trafalis, D.T.P; Peristeris, P
1Hit and Lead Identification: Efficient Practices for Drug Discovery
score: 1.0510244, Progress in Medicinal Chemistry, 2007, Goodnow, Robert; Gillespie, Paul
Hypersusceptibility of the Pseudomonas aeruginosa nfxB mutant to beta-lactams due to reduced expression of the ampC beta-lactamase.
score: 1.0509761, Antimicrobial agents and chemotherapy, 2001, Masuda, N; Sakagawa, E; Ohya, S; Gotoh, N; Nishino, T
In vivo activities of recombinant divercin V41 and its structural variants against Listeria monocytogenes.
score: 1.0509561, Antimicrobial agents and chemotherapy, 2010, Rihakova, Jitka et. al.
Unusual intramolecular N→ O acyl group migration occurring during conjugation of (−)-DHMEQ with cysteine
score: 1.0509426, Bioorganic & Medicinal Chemistry Letters, 2009, Kozawa, Ikuko et. al.
Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgen receptor
score: 1.0508554, European Journal of Medicinal Chemistry, 2002, He, Yali et. al.
Synthesis and evaluation of the in vivo trypanocidal activity of water soluble organotin compounds
score: 1.0508537, European Journal of Medicinal Chemistry, 1999, Susperregui, Jacques et. al.
Pharmacokinetics and pharmacodynamics of once-daily versus twice-daily raltegravir in treatment-naive HIV-infected patients.
score: 1.0507111, Antimicrobial agents and chemotherapy, 2012, Rizk, Matthew L et. al.
Antimicrobial resistance of diarrheagenic Escherichia coli isolated from children under the age of 5 years from Ifakara, Tanzania.
score: 1.0507061, Antimicrobial agents and chemotherapy, 1999, Vila, J et. al.
Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium.
score: 1.0506666, Antimicrobial agents and chemotherapy, 2004, van der Straaten, Tahar et. al.
Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives
score: 1.050621, European Journal of Medicinal Chemistry, 2006, Kolokythas, George et. al.
Determination of the chromosomal relationship between mecA and gyrA in methicillin-resistant coagulase-negative staphylococci.
score: 1.0506124, Antimicrobial agents and chemotherapy, 1998, Fey, P D; Climo, M W; Archer, G L
Dissemination of Acinetobacter baumannii clones with OXA-23 Carbapenemase in Colombian hospitals.
score: 1.0505489, Antimicrobial agents and chemotherapy, 2007, Villegas, Maria Virginia et. al.
Impact of antibiotic MIC on infection outcome in patients with susceptible Gram-negative bacteria: a systematic review and meta-analysis.
score: 1.050542, Antimicrobial agents and chemotherapy, 2012, Falagas, Matthew E et. al.
Study of the base discrimination ability of DNA and 2′- O-methylated RNA oligomers containing 2-thiouracil bases towards complementary RNA or DNA strands and their application to single base mismatch detection
score: 1.050487, Bioorganic & Medicinal Chemistry, 2008, Okamoto, Itaru; Seio, Kohji; Sekine, Mitsuo
The role of methylglyoxal in the non-enzymatic conversion of tryptophan, its methyl ester and tryptamine to 1-acetyl-β-carbolines
score: 1.0504866, Bioorganic & Medicinal Chemistry, 2008, Nemet, Ina; Varga-Defterdarović, Lidija
Vancomycin-resistant Enterococcus faecium strains isolated from community wastewater from a semiclosed agri-food system in Texas.
score: 1.0504754, Antimicrobial agents and chemotherapy, 2005, Poole, T L et. al.
The neurokinin-1 and neurokinin-2 receptor binding sites of MDL103,392 differ
score: 1.0504446, Bioorganic & Medicinal Chemistry, 1999, Greenfeder, Scott et. al.
Synthesis and DNA binding affinity of novel A- C8/ C- C2- exo unsaturated alkoxyamido-linked pyrrolo[2,1- c][1,4]benzodiazepine dimers
score: 1.0504222, Bioorganic & Medicinal Chemistry, 2004, Kamal, Ahmed et. al.
Inhibition of peptide amyloid formation by cationic peptides with homologous sequences
score: 1.0503949, Bioorganic & Medicinal Chemistry Letters, 2003, Yamashita, Taro et. al.
Relationship between various definitions of prior antibiotic exposure and piperacillin-tazobactam resistance among patients with respiratory tract infections caused by Pseudomonas aeruginosa.
score: 1.0503765, Antimicrobial agents and chemotherapy, 2008, Patel, Nimish; McNutt, Louise-Anne; Lodise, Thomas P
Isolation, characterization and biological evaluation of datura lactones as potential immunomodulators
score: 1.0503755, Bioorganic & Medicinal Chemistry, 2005, Bhat, B.A. et. al.
Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture.
score: 1.0503286, Antimicrobial agents and chemotherapy, 2007, Lee, Sui Mae et. al.
Secretion of proteases by Pseudomonas aeruginosa biofilms exposed to ciprofloxacin.
score: 1.0503212, Antimicrobial agents and chemotherapy, 2005, Ołdak, Ewa; Trafny, Elzbieta A
In vitro susceptibility of Coxiella burnetii to trovafloxacin in comparison with susceptibilities to pefloxacin, ciprofloxacin, ofloxacin, doxycycline, and clarithromycin.
score: 1.0503128, Antimicrobial agents and chemotherapy, 1998, Gikas, A et. al.
Hydrogen sulfide induces nitric oxide release from nitrite
score: 1.0502937, Bioorganic & Medicinal Chemistry Letters, 2009, Grossi, Loris
Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir.
score: 1.0502829, Antimicrobial agents and chemotherapy, 2011, Charpentier, Charlotte et. al.
Nucleotide and amino acid sequences of the metallo-beta-lactamase, ImiS, from Aeromonas veronii bv. sobria.
score: 1.0502132, Antimicrobial agents and chemotherapy, 1998, Walsh, T R et. al.
Population pharmacokinetics of lamivudine in adult human immunodeficiency virus-infected patients enrolled in two phase III clinical trials.
score: 1.0501659, Antimicrobial agents and chemotherapy, 1999, Moore, K H et. al.
Conformationally constrained ethylenediamines: synthesis and receptor binding of 6,8-Diazabicyclo[3.2.2]nonanes
score: 1.0500362, Bioorganic & Medicinal Chemistry, 2002, Weigl, Manuela et. al.
Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors
score: 1.049994, Bioorganic & Medicinal Chemistry, 2012, Xiao, Su-long et. al.
Analysis of human immunodeficiency virus type 1 reverse transcriptase subunit structure/function in the context of infectious virions and human target cells.
score: 1.0499419, Antimicrobial agents and chemotherapy, 2005, Mulky, Alok; Kappes, John C
Penicillin-binding protein 1A, 2B, and 2X alterations in Canadian isolates of penicillin-resistant Streptococcus pneumoniae.
score: 1.0499346, Antimicrobial agents and chemotherapy, 2002, Nichol, Kimberly A; Zhanel, George G; Hoban, Daryl J
Serine protease inhibitors block invasion of host cells by Toxoplasma gondii.
score: 1.0499124, Antimicrobial agents and chemotherapy, 1999, Conseil, V; Soête, M; Dubremetz, J F
Evolution and global dissemination of macrolide-resistant group A streptococci.
score: 1.0498578, Antimicrobial agents and chemotherapy, 2006, Robinson, D Ashley et. al.
Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses.
score: 1.0498115, Antimicrobial agents and chemotherapy, 2011, Zheng, Qingbing et. al.
In vitro antimicrobial susceptibility to isepamicin of 6,296 Enterobacteriaceae clinical isolates collected at a tertiary care university hospital in Greece.
score: 1.0497753, Antimicrobial agents and chemotherapy, 2012, Maraki, Sofia et. al.
In vitro evaluation of double and triple combinations of antifungal drugs against Aspergillus fumigatus and Aspergillus terreus.
score: 1.0497531, Antimicrobial agents and chemotherapy, 2004, Dannaoui, Eric; Lortholary, Olivier; Dromer, Françoise
Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin.
score: 1.0497362, Antimicrobial agents and chemotherapy, 2004, Bucki, Robert et. al.
Heterocycle-functional gramine analogues: Solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation
score: 1.0497241, European Journal of Medicinal Chemistry, 2012, Ke, Shaoyong et. al.
Putting small molecules in the lead.
score: 1.0496546, Nature chemical biology, 2005, Jaroch, Stefan; Weinmann, Hilmar
Strain-specific expression levels of pbp4 exist in isolates of glycopeptide-intermediate Staphylococcus aureus (GISA) and heterogeneous GISA.
score: 1.0496293, Antimicrobial agents and chemotherapy, 2005, Wootton, M; Bennett, P M; MacGowan, A P; Walsh, T R
Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients.
score: 1.0496023, Antimicrobial agents and chemotherapy, 1998, Ji, B et. al.
Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp.
score: 1.0496005, Antimicrobial agents and chemotherapy, 2001, Kaye, K S et. al.
First report of the carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter baumannii isolates in Italy.
score: 1.049556, Antimicrobial agents and chemotherapy, 2006, Bertini, Alessia et. al.
New cytotoxic-antineoplastic prenyl-1,2-naphthohydroquinone derivatives
score: 1.0495396, Bioorganic & Medicinal Chemistry, 2005, Molinari, Aurora et. al.
Antimicrobial susceptibility of Neisseria gonorrhoeae in Fukuoka City, Japan, in the early 1980s and 1997-1998: emergence of high-level fluoroquinolone resistance.
score: 1.0495127, Antimicrobial agents and chemotherapy, 1999, Tanaka, M; Naito, S; Nakayama, H; Kobayashi, I
First isolation of bla(VIM-2) in Latin America: report from the SENTRY Antimicrobial Surveillance Program.
score: 1.0495127, Antimicrobial agents and chemotherapy, 2004, Mendes, Rodrigo E et. al.
Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy.
score: 1.0495035, Antimicrobial agents and chemotherapy, 2002, van Praag, Rieneke M E et. al.
In vitro interactions of micafungin with amphotericin B against clinical isolates of Candida spp.
score: 1.0494372, Antimicrobial agents and chemotherapy, 2008, Serena, Carolina et. al.
Pharmacokinetics of [18F]trovafloxacin in healthy human subjects studied with positron emission tomography.
score: 1.0493323, Antimicrobial agents and chemotherapy, 1998, Fischman, A J et. al.
Inhibitors from Rhubarb on Lipopolysaccharide-Induced Nitric Oxide Production in Macrophages: Structural Requirements of Stilbenes for the Activity
score: 1.0493251, Bioorganic & Medicinal Chemistry, 2001, Kageura, Tadashi et. al.
Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B.
score: 1.0493087, Antimicrobial agents and chemotherapy, 2003, Hornby, Jacob M; Kebaara, Bessie W; Nickerson, Kenneth W
In vivo increase in resistance to ciprofloxacin in Escherichia coli associated with deletion of the C-terminal part of MarR.
score: 1.0492253, Antimicrobial agents and chemotherapy, 2000, Linde, H J et. al.
Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold
score: 1.0492049, Bioorganic & Medicinal Chemistry, 2004, Zhong, Jiaying et. al.
Efficacy of combined therapy with liposome-encapsulated meglumine antimoniate and allopurinol in treatment of canine visceral leishmaniasis.
score: 1.0491764, Antimicrobial agents and chemotherapy, 2012, da Silva, Sydnei M et. al.
In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies.
score: 1.0491256, Antimicrobial agents and chemotherapy, 2002, Ramage, Gordon et. al.
In vivo reversion to the wild-type beta-lactam resistance phenotype mediated by a plasmid carrying ampR and qnrA1 in Enterobacter cloacae.
score: 1.0491151, Antimicrobial agents and chemotherapy, 2006, González-López, J J et. al.
The Candida dubliniensis CdCDR1 gene is not essential for fluconazole resistance.
score: 1.0491142, Antimicrobial agents and chemotherapy, 2002, Moran, Gary et. al.
FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C.
score: 1.0490641, Antimicrobial agents and chemotherapy, 2004, Ohyama, Takao; Miyakoshi, Shunichi; Isono, Fujio
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
score: 1.0490484, Bioorganic & Medicinal Chemistry, 2012, Májer, Ferenc et. al.
Design, synthesis, and characterization of peptide nanostructures having ion channel activity
score: 1.0490387, Bioorganic & Medicinal Chemistry, 2004, Biron, Eric et. al.
International spread of bla(CMY-2)-mediated cephalosporin resistance in a multiresistant Salmonella enterica serovar Heidelberg isolate stemming from the importation of a boar by Denmark from Canada.
score: 1.0490231, Antimicrobial agents and chemotherapy, 2004, Aarestrup, Frank M et. al.
Imidazoline-modified benzylimidazolines as h5-HT 1D/1B serotonergic ligands
score: 1.0490068, Bioorganic & Medicinal Chemistry, 2001, Prisinzano, Thomas et. al.
The Inactivation of Intrinsic Antibiotic Resistance Determinants Widens the Mutant Selection Window for Quinolones in Stenotrophomonas maltophilia.
score: 1.0489646, Antimicrobial agents and chemotherapy, 2012, García-León, Guillermo; Sánchez, María B; Martínez, José L
Proposal of new modification technique for linear double-stranded DNAs using the polysaccharide schizopyllan
score: 1.0488853, Bioorganic & Medicinal Chemistry Letters, 2004, Anada, Takahisa et. al.
Using enzymatic amplification by aldolase for the optical detection of DNA by an artificial signal cascade
score: 1.0487481, Bioorganic & Medicinal Chemistry Letters, 2008, Graf, Nora; Kassube, Susanne; Krämer, Roland
Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases.
score: 1.0487156, Antimicrobial agents and chemotherapy, 2003, Hoyen, Claudia K et. al.
Dissemination of an extended-spectrum-beta-lactamase blaTEM-52 gene-carrying IncI1 plasmid in various Salmonella enterica serovars isolated from poultry and humans in Belgium and France between 2001 and 2005.
score: 1.0486847, Antimicrobial agents and chemotherapy, 2007, Cloeckaert, Axel et. al.
Artemisinin and heme.
score: 1.0486452, Antimicrobial agents and chemotherapy, 2003, Meshnick, Steven R
Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH 3)CL 2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-α)pyridine
score: 1.0486276, European Journal of Medicinal Chemistry, 2004, Huq, Fazlul et. al.
A Highly Selective Hsp90 Affinity Chromatography Resin with a Cleavable Linker
score: 1.0485914, Bioorganic & Medicinal Chemistry, 2012, Hughes, Philip F. et. al.
Biocatalysed synthesis of β- O-glucosides from 9-fluorenon-2-carbohydroxyesters. Part 3: IFN-inducing and anti-HSV-2 properties
score: 1.0485556, Bioorganic & Medicinal Chemistry, 2005, Alcaro, Stefano et. al.
Fluoroquinolone-resistant urinary isolates of Escherichia coli from outpatients are frequently multidrug resistant: results from the North American Urinary Tract Infection Collaborative Alliance-Quinolone Resistance study.
score: 1.0485226, Antimicrobial agents and chemotherapy, 2006, Karlowsky, James A et. al.
Continuous infusion may improve the efficacy of vancomycin in treatment of experimental endocarditis due to heterogeneous vancomycin-intermediate Staphylococcus aureus.
score: 1.0484673, Antimicrobial agents and chemotherapy, 2011, Pea, Federico et. al.
In vitro activities of 15 antimicrobial agents against clinical isolates of South African enterococci.
score: 1.0483827, Antimicrobial agents and chemotherapy, 1998, Struwig, M C; Botha, P L; Chalkley, L J
Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.
score: 1.048333, Antimicrobial agents and chemotherapy, 2009, Bryan, Ruth A et. al.
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ
score: 1.0483227, Bioorganic & Medicinal Chemistry, 1997, Irie, Kazuhiro et. al.
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ
score: 1.0483227, Bioorganic & Medicinal Chemistry, 1997, Irie, Kazuhiro et. al.
Alkylidene branched lupane derivatives: Synthesis and antitumor activity
score: 1.0482409, European Journal of Medicinal Chemistry, 2012, Csuk, René et. al.
Alkylidene branched lupane derivatives: Synthesis and antitumor activity
score: 1.0482409, European Journal of Medicinal Chemistry, 2012, Csuk, René et. al.
A novel antimicrobial epoxide isolated from larval Galleria mellonella infected by the nematode symbiont, Photorhabdus luminescens (Enterobacteriaceae)
score: 1.0482359, Bioorganic & Medicinal Chemistry, 2006, Hu, Kaiji et. al.
In vitro activities of OPT-80 and comparator drugs against intestinal bacteria.
score: 1.0482291, Antimicrobial agents and chemotherapy, 2004, Finegold, Sydney M et. al.
Antimicrobial susceptibilities of group B streptococci isolated between 1992 and 1996 from patients with bacteremia or meningitis.
score: 1.0482246, Antimicrobial agents and chemotherapy, 1998, Fernandez, M; Hickman, M E; Baker, C J
N-Acyl substituted 7-amino-4-chloroisocoumarin: A peptide degradation model via an imide mechanism
score: 1.0481477, Bioorganic & Medicinal Chemistry Letters, 2004, Garino, Cédrik et. al.
MpeR regulates the mtr efflux locus in Neisseria gonorrhoeae and modulates antimicrobial resistance by an iron-responsive mechanism.
score: 1.0478542, Antimicrobial agents and chemotherapy, 2012, Mercante, Alexandra Dubon et. al.
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria.
score: 1.0478235, Antimicrobial agents and chemotherapy, 2007, Oyakhirome, Sunny et. al.
Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel.
score: 1.0477795, Antimicrobial agents and chemotherapy, 2006, Navon-Venezia, Shiri et. al.
Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones.
score: 1.047776, Antimicrobial agents and chemotherapy, 2001, Kenny, G E; Cartwright, F D
Identification of potential glycogen kinase-3 inhibitors by structure based virtual screening
score: 1.0477668, Biophysical Chemistry, 2007, Dessalew, Nigus; Bharatam, Prasad V.
Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents
score: 1.0476813, Bioorganic & Medicinal Chemistry Letters, 2010, Bera, Smritilekha; Zhanel, George G.; Schweizer, Frank
In vitro characterization of the Gd complex of [2,6-pyridinediylbis(methylene nitrilo)] tetraacetic acid (PMN-tetraacetic acid) and of its Eu analogue, suitable bimodal contrast agents for MRI and optical imaging
score: 1.0476661, Bioorganic & Medicinal Chemistry Letters, 2007, Laurent, S. et. al.
A novel integron in Salmonella enterica serovar Enteritidis, carrying the bla(DHA-1) gene and its regulator gene ampR, originated from Morganella morganii.
score: 1.0476634, Antimicrobial agents and chemotherapy, 2000, Verdet, C; Arlet, G; Barnaud, G; Lagrange, P H; Philippon, A
In vitro activities of gemifloxacin versus five quinolones and two macrolides against 271 Spanish isolates of Legionella pneumophila: influence of charcoal on susceptibility test results.
score: 1.0475833, Antimicrobial agents and chemotherapy, 2000, García, M T; Pelaz, C; Giménez, M J; Aguilar, L
Structure–reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets
score: 1.0475719, Bioorganic & Medicinal Chemistry, 2008, Campodónico, Paola R.; Contreras, Renato
Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.
score: 1.0475699, Antimicrobial agents and chemotherapy, 2005, Bignell, Dawn R D et. al.
Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones.
score: 1.047478, Antimicrobial agents and chemotherapy, 2004, Ito, Masayasu et. al.
Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities
score: 1.0474625, European Journal of Medicinal Chemistry, 2004, Demirayak, Seref; Karaburun, Ahmet Cagri; Beis, Rana
Low-level resistance to rifampin in Streptococcus pneumoniae.
score: 1.0474507, Antimicrobial agents and chemotherapy, 2003, Meier, Patricia Stutzmann et. al.
Ciprofloxacin-resistant gram-negative bacilli in the fecal microflora of children.
score: 1.047428, Antimicrobial agents and chemotherapy, 2006, Qin, Xuan et. al.
Predicting the activity of drugs for a group of imidazopyridine anticoccidial compounds
score: 1.047254, European Journal of Medicinal Chemistry, 2009, Si, Hongzong et. al.
Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection.
score: 1.0472492, Antimicrobial agents and chemotherapy, 2002, Olivieri, Bianca Perdigão et. al.
Design of orally active, non-peptide fibrinogen receptor antagonists. An evolutionary process from the RGD sequence to novel anti-platelet aggregation agents
score: 1.0472116, Bioorganic & Medicinal Chemistry, 1994, Bovy, P.R. et. al.
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases
score: 1.0472019, Bioorganic & Medicinal Chemistry, 2012, Mak, Lok Hang et. al.
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases
score: 1.0472019, Bioorganic & Medicinal Chemistry, 2012, Mak, Lok Hang et. al.
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases
score: 1.0472019, Bioorganic & Medicinal Chemistry, 2012, Mak, Lok Hang et. al.
Cross-resistance to lincosamides, streptogramins A, and pleuromutilins due to the lsa(C) gene in Streptococcus agalactiae UCN70.
score: 1.0471935, Antimicrobial agents and chemotherapy, 2011, Malbruny, Brigitte et. al.
Antioxidant properties of Mannich bases
score: 1.0470618, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Dong Ho et. al.
Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E 2
score: 1.0470474, Bioorganic & Medicinal Chemistry, 2006, Cho, Hoon et. al.
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
score: 1.046855, Antimicrobial agents and chemotherapy, 2010, Shekalaghe, Seif A et. al.
Site-specific mutagenesis analysis of PBP 1A from a penicillin-cephalosporin-resistant pneumococcal isolate.
score: 1.0468428, Antimicrobial agents and chemotherapy, 2003, Smith, Anthony M; Klugman, Keith P
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
score: 1.0468199, Antimicrobial agents and chemotherapy, 2005, Szabó, Dóra et. al.
Optimization of acetonitrile co-solvent and copper stoichiometry for pseudo-ligandless click chemistry with nucleic acids
score: 1.0467851, Bioorganic & Medicinal Chemistry Letters, 2012, Paredes, Eduardo; Das, Subha R.
Modification of the swern oxidation: use of a recyclable, polystyrene bound sulfoxide
score: 1.0467661, Bioorganic & Medicinal Chemistry Letters, 2002, Cole, Derek C; Stock, Joseph R; Kappel, Jo Anne
Correlation between in vitro susceptibility of Scedosporium apiospermum to voriconazole and in vivo outcome of scedosporiosis in guinea pigs.
score: 1.0466555, Antimicrobial agents and chemotherapy, 2004, Capilla, Javier; Guarro, Josep
Comparative study of the effects of ceftizoxime, piperacillin, and piperacillin-tazobactam concentrations on antibacterial activity and selection of antibiotic-resistant mutants of Enterobacter cloacae and Bacteroides fragilis in vitro and in vivo in mixed-infection abscesses.
score: 1.046616, Antimicrobial agents and chemotherapy, 2004, Stearne, Lorna E T et. al.
Enhanced production of phospholipase C and perfringolysin O (alpha and theta toxins) in a gatifloxacin-resistant strain of Clostridium perfringens.
score: 1.0465047, Antimicrobial agents and chemotherapy, 2008, Rafii, Fatemeh et. al.
Evidence for biliary excretion of vancomycin into stool during intravenous therapy: potential implications for rectal colonization with vancomycin-resistant enterococci.
score: 1.0464973, Antimicrobial agents and chemotherapy, 2004, Currie, Brian P; Lemos-Filho, Luciano
Chemical genetics resulting from a passion for synthetic organic chemistry
score: 1.0464802, Bioorganic & Medicinal Chemistry, 1998, Schreiber, Stuart L.
Glycopeptide-resistant Enterococcus faecium BM4416 is a VanD-type strain with an impaired D-Alanine:D-Alanine ligase.
score: 1.0464656, Antimicrobial agents and chemotherapy, 2000, Perichon, B; Casadewall, B; Reynolds, P; Courvalin, P
Activities of newer quinolones against Escherichia coli and Klebsiella pneumoniae containing the plasmid-mediated quinolone resistance determinant qnr.
score: 1.0464618, Antimicrobial agents and chemotherapy, 2004, Wang, Minggui et. al.
Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis
score: 1.046461, European Journal of Medicinal Chemistry, 2012, Ilić, Miloš et. al.
Advantages and limitation of BODIPY as a probe for the evaluation of lipid peroxidation and its inhibition by antioxidants in plasma
score: 1.0464313, Bioorganic & Medicinal Chemistry Letters, 2007, Itoh, Nanako et. al.
Photodynamic inactivation of Candida albicans using bridged polysilsesquioxane films doped with porphyrin
score: 1.046417, Bioorganic & Medicinal Chemistry, 2012, Alvarez, M. Gabriela et. al.
Photodynamic inactivation of Candida albicans using bridged polysilsesquioxane films doped with porphyrin
score: 1.046417, Bioorganic & Medicinal Chemistry, 2012, Alvarez, M. Gabriela et. al.
In vitro antimycoplasmal activity of citrus bergamia essential oil and its major components
score: 1.0463615, European Journal of Medicinal Chemistry, 2012, Furneri, Pio Maria et. al.
Emergence of Enterobacteriaceae isolates producing CTX-M extended-spectrum beta-lactamase in Austria.
score: 1.0463528, Antimicrobial agents and chemotherapy, 2006, Eisner, Alexandra et. al.
Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis.
score: 1.0463295, Antimicrobial agents and chemotherapy, 2011, Wallis, Robert S et. al.
New analgesic and antiinflammatory agents 4(1H)-pyridinone derivatives
score: 1.0462567, European Journal of Medicinal Chemistry, 2002, Öztürk, Gülcan et. al.
Synthesis, antimicrobial and cytotoxic activities of sulfone linked bis heterocycles
score: 1.0462493, European Journal of Medicinal Chemistry, 2012, Muralikrishna, A. et. al.
Estimation of the effect of the acidosis and alkalosis on the anesthetic potency of local anesthetics by biopartitioning micellar chromatography and micellar electrokinetic chromatography
score: 1.0460747, European Journal of Medicinal Chemistry, 2005, Canós-Rius, N. et. al.
Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany.
score: 1.0460548, Antimicrobial agents and chemotherapy, 2003, Reinert, Ralf René et. al.
Novel synthesis and anti-inflammatory activities of 2,5-disubstituted-dioxacycloalkanes
score: 1.0460488, Bioorganic & Medicinal Chemistry, 2005, Bi, Lanrong et. al.
In vitro selection and characterization of Bacillus anthracis mutants with high-level resistance to ciprofloxacin.
score: 1.0460434, Antimicrobial agents and chemotherapy, 2003, Price, Lance B et. al.
The immunosuppressant rapamycin represses human immunodeficiency virus type 1 replication.
score: 1.0459961, Antimicrobial agents and chemotherapy, 2002, Roy, Jocelyn et. al.
Ethambutol pharmacokinetic variability is linked to body mass in overweight, obese, and extremely obese people.
score: 1.0459285, Antimicrobial agents and chemotherapy, 2012, Hall, Ronald G et. al.
Detection and quantification of macrolide resistance mutations at positions 2058 and 2059 of the 23S rRNA gene by pyrosequencing.
score: 1.0459207, Antimicrobial agents and chemotherapy, 2005, Haanperä, Marjo; Huovinen, Pentti; Jalava, Jari
Isoniazid pharmacokinetics-pharmacodynamics in an aerosol infection model of tuberculosis.
score: 1.0459031, Antimicrobial agents and chemotherapy, 2004, Jayaram, Ramesh et. al.
Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans.
score: 1.0459013, Antimicrobial agents and chemotherapy, 2008, Bryan, Ruth A et. al.
Selection of an antibiotic-hypersusceptible mutant of Pseudomonas aeruginosa: identification of the GlmR transcriptional regulator.
score: 1.0458598, Antimicrobial agents and chemotherapy, 2004, Ramos-Aires, Julio et. al.
QSAR studies on some thiophene analogs as anti-inflammatory agents: enhancement of activity by electronic parameters and its utilization for chemical lead optimization
score: 1.0457142, Bioorganic & Medicinal Chemistry, 2005, Pillai, Ajay D. et. al.
Synthesis of β- D-arabinofuranosyl-1-monophosphoryl polyprenols: Examination of their function as mycobacterial arabinosyl transferase donors
score: 1.045683, Bioorganic & Medicinal Chemistry Letters, 1998, Lee, R.E; Brennan, P.J; Besra, G.S
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B
score: 1.0456799, European Journal of Medicinal Chemistry, 2012, Balaydın, Halis T. et. al.
Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever.
score: 1.045623, Antimicrobial agents and chemotherapy, 2009, Phan, Minh-Duy et. al.
Antibiotic resistance in Campylobacter strains isolated from animals, foods, and humans in Spain in 1997-1998.
score: 1.0455187, Antimicrobial agents and chemotherapy, 2000, Sáenz, Y et. al.
SER-HIS-ASP catalytic triad in model non-aqueous solvent environment: A computational study
score: 1.0455035, Bioorganic & Medicinal Chemistry Letters, 2006, Lau, Justin Kai-Chi; Cheng, Yuen-Kit
Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom.
score: 1.045501, Antimicrobial agents and chemotherapy, 2012, Giske, Christian G et. al.
Effects of rilpivirine on human adipocyte differentiation, gene expression, and release of adipokines and cytokines.
score: 1.0454619, Antimicrobial agents and chemotherapy, 2012, Díaz-Delfín, Julieta et. al.
Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis.
score: 1.0454499, Antimicrobial agents and chemotherapy, 2000, McKessar, S J et. al.
Alteration of Escherichia coli topoisomerase IV to novobiocin resistance.
score: 1.0453888, Antimicrobial agents and chemotherapy, 2003, Hardy, Christine D; Cozzarelli, Nicholas R
First Canadian Salmonella enterica serovar typhi isolate harboring an integron.
score: 1.045383, Antimicrobial agents and chemotherapy, 2004, Mulvey, Michael R et. al.
Comparison of ceftriaxone, amikacin, and ciprofloxacin in treatment of experimental Yersinia enterocolitica O9 infection in mice.
score: 1.0453393, Antimicrobial agents and chemotherapy, 1998, Jiménez-Valera, M et. al.
Synthesis and separation of diastereomers of uridine 2′,3′-cyclic boranophosphate
score: 1.0453192, Bioorganic & Medicinal Chemistry Letters, 2001, He, Kaizhang; Shaw, Barbara Ramsay
Blood, tissue, and intracellular concentrations of erythromycin and its metabolite anhydroerythromycin during and after therapy.
score: 1.0452756, Antimicrobial agents and chemotherapy, 2012, Krasniqi, S et. al.
Breakthrough bacteremia due to extended-spectrum-β-lactamase-producing Klebsiella pneumoniae during combination therapy with colistin and tigecycline.
score: 1.0452718, Antimicrobial agents and chemotherapy, 2012, Cho, Sun Young et. al.
Optimal control strategies for disinfection of bacterial populations with persister and susceptible dynamics.
score: 1.0451921, Antimicrobial agents and chemotherapy, 2012, Cogan, N G; Brown, Jason; Darres, Kyle; Petty, Katherine
Overexpression of Erg11p by the regulatable GAL1 promoter confers fluconazole resistance in Saccharomyces cerevisiae.
score: 1.0451918, Antimicrobial agents and chemotherapy, 1999, Kontoyiannis, D P; Sagar, N; Hirschi, K D
Pulsatile delivery of clarithromycin alone or in combination with amoxicillin against Streptococcus pneumoniae.
score: 1.0451827, Antimicrobial agents and chemotherapy, 2006, Leuthner, Kimberly D; Cheung, Chrissy M; Rybak, Michael J
Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump.
score: 1.0451513, Antimicrobial agents and chemotherapy, 2000, Oethinger, M et. al.
Beneficial effect of cesium salts on Pd-catalyzed hydroxycarbonylation
score: 1.0451267, Bioorganic & Medicinal Chemistry Letters, 2000, Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Recommendation of an appropriate medium for in vitro drug susceptibility testing of the fish pathogen Tenacibaculum maritimum.
score: 1.0450998, Antimicrobial agents and chemotherapy, 2005, Avendaño-Herrera, Ruben et. al.
Mechanism of fluoroquinolone resistance is an important factor in determining the antimicrobial effect of gemifloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model.
score: 1.0450875, Antimicrobial agents and chemotherapy, 2003, MacGowan, Alasdair P; Bowker, Karen E
Population pharmacokinetics of palivizumab, a humanized anti-respiratory syncytial virus monoclonal antibody, in adults and children.
score: 1.0450297, Antimicrobial agents and chemotherapy, 2012, Robbie, Gabriel J et. al.
Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 years.
score: 1.0450261, Antimicrobial agents and chemotherapy, 2006, Jullien, Vincent et. al.
Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria.
score: 1.0450184, Antimicrobial agents and chemotherapy, 2001, Davis, T M et. al.
Identification of RNase 8 as a novel human antimicrobial protein.
score: 1.0449941, Antimicrobial agents and chemotherapy, 2006, Rudolph, Bente et. al.
Precise structural elucidation of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase α
score: 1.0449759, Bioorganic & Medicinal Chemistry, 2004, Kamisuki, Shinji et. al.
A new type of carboxypeptidase a inhibitors designed using an imidazole as a zinc coordinating ligand
score: 1.0449546, Bioorganic & Medicinal Chemistry, 1997, Lee, Kyung Joo et. al.
Construction of the novel conformationally-restricted peptide library for screening of peptides that control the interaction Between nucleobases
score: 1.0449364, Bioorganic & Medicinal Chemistry Letters, 2002, Takahashi, Mizuki; Ueno, Akihiko; Mihara, Hisakazu
Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.
score: 1.0449008, Antimicrobial agents and chemotherapy, 2002, Nagl, Markus et. al.
Synthesis of substrate analogs of methyltransferases in the vitamin B 12 biosynthetic pathway and characterization of their enzymatic products
score: 1.0448818, Bioorganic & Medicinal Chemistry, 2006, Pichon-Santander, Clotilde et. al.
Duration and clinical relevance of postantibiotic effect in relation to the dosing interval.
score: 1.0448348, Antimicrobial agents and chemotherapy, 1998, den Hollander, J G; Fuursted, K; Verbrugh, H A; Mouton, J W
Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae.
score: 1.0448237, Antimicrobial agents and chemotherapy, 2003, Ibrahim, Ashraf S et. al.
Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes.
score: 1.0447223, Antimicrobial agents and chemotherapy, 2011, Hightower, Kendra E et. al.
CENTA as a chromogenic substrate for studying beta-lactamases.
score: 1.0446815, Antimicrobial agents and chemotherapy, 2001, Bebrone, C et. al.
Role of the galactosyl moiety of collagen glycopeptides for T-Cell stimulation in a model for rheumatoid arthritis
score: 1.0446683, Bioorganic & Medicinal Chemistry, 2003, Holm, Björn et. al.
Chemically modified oligonucleotides with efficient RNase H response
score: 1.044665, Bioorganic & Medicinal Chemistry Letters, 2008, Vester, Birte et. al.
Differential phenotypic and genotypic characteristics of qnrS1-harboring plasmids carried by hospital and community commensal enterobacteria.
score: 1.0446611, Antimicrobial agents and chemotherapy, 2011, Vien, Le Thi Minh et. al.
Antibiotic resistance and distribution of tetracycline resistance genes in Escherichia coli O157:H7 isolates from humans and bovines.
score: 1.0446582, Antimicrobial agents and chemotherapy, 2004, Wilkerson, Chris et. al.
Effect of culture medium on the disk diffusion method for determining antifungal susceptibilities of dermatophytes.
score: 1.044617, Antimicrobial agents and chemotherapy, 2006, Fernández-Torres, Belkys et. al.
Synthesis, study of 3D structures, and pharmacological activities of lipophilic nitroimidazolyl-1,4-dihydropyridines as calcium channel antagonist
score: 1.0445965, Bioorganic & Medicinal Chemistry, 2006, Miri, Ramin et. al.
Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms.
score: 1.0445821, Antimicrobial agents and chemotherapy, 2011, Hengzhuang, Wang et. al.
Population pharmacokinetics of atazanavir in patients with human immunodeficiency virus infection.
score: 1.0445379, Antimicrobial agents and chemotherapy, 2006, Colombo, Sara et. al.
Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.
score: 1.0444339, Antimicrobial agents and chemotherapy, 2010, Mitsui, Fukiko et. al.
Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides.
score: 1.044422, Antimicrobial agents and chemotherapy, 2002, Prunier, Anne-Laure et. al.
Synthesis of Schiff bases of 4-(4-aminophenyl)-morpholine as potential antimicrobial agents
score: 1.0442855, European Journal of Medicinal Chemistry, 2005, Panneerselvam, Perumal et. al.
Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity.
score: 1.0442027, Antimicrobial agents and chemotherapy, 1999, Rybak, M J et. al.
Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis.
score: 1.0441866, Antimicrobial agents and chemotherapy, 2000, Dhawan, V K; Bayer, A S; Yeaman, M R
Biomimetic synthesis of xuxuarines Eα and Eβ: Structure revision of Rzedowskia bistriterpenoids
score: 1.0441177, Bioorganic & Medicinal Chemistry, 2008, Jacobsen, Neil E. et. al.
Facile synthesis of metal-chelating peptides on chip for protein array
score: 1.0440993, Bioorganic & Medicinal Chemistry Letters, 2004, Cheng, Ching-Wen et. al.
Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56 + NK-cell cytotoxicity in cord blood
score: 1.0439926, Bioorganic & Medicinal Chemistry, 2004, Chien, Chichen Michael et. al.
Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation.
score: 1.0439141, Antimicrobial agents and chemotherapy, 2007, Henrichfreise, B; Wiegand, I; Pfister, W; Wiedemann, B
Pharmacophore-based small molecule CXCR4 ligands
score: 1.0438182, Bioorganic & Medicinal Chemistry Letters, 2012, Narumi, Tetsuo et. al.
Structure–activity relationship study at the 3′- N-position of paclitaxel: synthesis and biological evaluation of 3′- N-acyl-paclitaxel analogues
score: 1.0437898, Bioorganic & Medicinal Chemistry, 2002, Roh, Eun Joo et. al.
Design of Ga–DOTA-based bifunctional radiopharmaceuticals: Two functional moieties can be conjugated to radiogallium–DOTA without reducing the complex stability
score: 1.0437797, Bioorganic & Medicinal Chemistry, 2009, Mukai, Takahiro et. al.
Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
score: 1.043776, European Journal of Medicinal Chemistry, 2006, Li, Yue-Qing et. al.
Recovery of a functional class 2 integron from an Escherichia coli strain mediating a urinary tract infection.
score: 1.0437558, Antimicrobial agents and chemotherapy, 2008, Márquez, Carolina et. al.
Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold
score: 1.0437511, Bioorganic & Medicinal Chemistry, 2012, Gomaa, Mohamed S. et. al.
Anti-calmodulin acridone derivatives modulate vinblastine resistance in multidrug resistant (MDR) cancer cells
score: 1.0437491, European Journal of Medicinal Chemistry, 2004, Hegde, Ravi et. al.
Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults.
score: 1.0437474, Antimicrobial agents and chemotherapy, 2009, Lebeaux, David et. al.
Comparative pharmacodynamics of three newer fluoroquinolones versus six strains of staphylococci in an in vitro model under aerobic and anaerobic conditions.
score: 1.0436478, Antimicrobial agents and chemotherapy, 2002, Wright, David H et. al.
Efficacy of low-dose dopamine in preventing amphotericin B nephrotoxicity in bone marrow transplant patients and leukemia patients.
score: 1.043641, Antimicrobial agents and chemotherapy, 1998, Camp, M J et. al.
TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone.
score: 1.0436126, Antimicrobial agents and chemotherapy, 2002, Dumarche, P et. al.
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.
score: 1.0435245, Antimicrobial agents and chemotherapy, 2000, Riccio, M L et. al.
Microbial growth inhibition by alternating electric fields.
score: 1.0434951, Antimicrobial agents and chemotherapy, 2008, Giladi, Moshe et. al.
Inhibition of the autolytic system by vancomycin causes mimicry of vancomycin-intermediate Staphylococcus aureus-type resistance, cell concentration dependence of the MIC, and antibiotic tolerance in vancomycin-susceptible S. aureus.
score: 1.0434928, Antimicrobial agents and chemotherapy, 2006, Sieradzki, Krzysztof; Tomasz, Alexander
Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis
score: 1.0434715, Bioorganic & Medicinal Chemistry, 2005, Holm, Lotta; Kjellén, Peter; Holmdahl, Rikard; Kihlberg, Jan
Electron transfer through DNA and peptides
score: 1.0434405, Bioorganic & Medicinal Chemistry, 2006, Giese, Bernd
Proteoglycan and collagen biochemical variations during fluoroquinolone-induced chondrotoxicity in mice.
score: 1.0433161, Antimicrobial agents and chemotherapy, 1999, Simonin, M A et. al.
Identification and expression of multidrug transporters responsible for fluconazole resistance in Candida dubliniensis.
score: 1.0432866, Antimicrobial agents and chemotherapy, 1998, Moran, G P et. al.
New N-arylsulfonyl- N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)
score: 1.0431444, Bioorganic & Medicinal Chemistry, 2004, Rossello, Armando et. al.
Novel lipophilic chloroquine analogues for a highly efficient gene transfer into gynecological tumors
score: 1.0431123, Bioorganic & Medicinal Chemistry Letters, 2001, Keil, Oliver; Bojar, Hans; Prisack, Hans-Bernd; Dall, Peter
Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1 H-indole-3-carboxylates
score: 1.0430998, Bioorganic & Medicinal Chemistry, 2006, Chai, Huifang; Zhao, Yanfang; Zhao, Chunshen; Gong, Ping
Amino acids and peptides. Part 39: A bivalent poly(ethylene glycol) hybrid containing an active site (RGD) and its synergistic site (PHSRN) of fibronectin
score: 1.0430503, Bioorganic & Medicinal Chemistry Letters, 2001, Hojo, Keiko et. al.
Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis.
score: 1.0430371, Antimicrobial agents and chemotherapy, 2005, Boigegrain, Rose-Anne et. al.
Chemotherapy-associated changes of histopathological features of Mycobacterium ulcerans lesions in a Buruli ulcer mouse model.
score: 1.0430121, Antimicrobial agents and chemotherapy, 2012, Ruf, Marie-Thérèse et. al.
Synthesis of β-Substituted Naphth-1-yl Ethylamido Derivatives as New Melatoninergic agonists
score: 1.0429446, Bioorganic & Medicinal Chemistry, 1999, Mathé-Allainmat, Monique et. al.
Incidence of quinolone resistance over the period 1986 to 1998 in veterinary Salmonella isolates from Germany.
score: 1.0429441, Antimicrobial agents and chemotherapy, 1999, Malorny, B; Schroeter, A; Helmuth, R
Identification of a novel beta-lactamase produced by Xanthomonas campestris, a phytopathogenic bacterium.
score: 1.0428627, Antimicrobial agents and chemotherapy, 1999, Weng, S F; Chen, C Y; Lee, Y S; Lin, J W; Tseng, Y H
Comparative molecular analysis of community- or hospital-acquired methicillin-resistant Staphylococcus aureus.
score: 1.0428502, Antimicrobial agents and chemotherapy, 2003, Fey, P D et. al.
Trovafloxacin concentrations in airway fluids of patients with severe community-acquired pneumonia.
score: 1.0427949, Antimicrobial agents and chemotherapy, 2000, Peleman, R A et. al.
Copper-metalated peptide palindrome derived from prion octarepeat: synthesis, aggregation, and oxidative transformations
score: 1.0427528, Bioorganic & Medicinal Chemistry, 2005, Madhavaiah, C.; Verma, Sandeep
Mucroporin, the first cationic host defense peptide from the venom of Lychas mucronatus.
score: 1.0427296, Antimicrobial agents and chemotherapy, 2008, Dai, Chao et. al.
Efficacy of locally delivered polyclonal immunoglobulin against Pseudomonas aeruginosa peritonitis in a murine model.
score: 1.0427149, Antimicrobial agents and chemotherapy, 1999, Barekzi, N A et. al.
Dose-dependent pharmacokinetics of amphotericin B lipid complex in rabbits.
score: 1.0426536, Antimicrobial agents and chemotherapy, 2000, Walsh, T J et. al.
The case for configurational stability of H-phosphonate diesters in the presence of diazabicyclo[5.4.0]undec-7-ene (DBU)
score: 1.0426042, Bioorganic & Medicinal Chemistry, 2001, Johansson, Tommy; Stawinski, Jacek
In vitro pharmacodynamics of amphotericin B, itraconazole, and voriconazole against Aspergillus, Fusarium, and Scedosporium spp.
score: 1.0425967, Antimicrobial agents and chemotherapy, 2005, Lewis, Russell E; Wiederhold, Nathan P; Klepser, Michael E
Pharmacokinetic profile and tolerability of indinavir-ritonavir combinations in healthy volunteers.
score: 1.042582, Antimicrobial agents and chemotherapy, 2001, Saah, A J et. al.
First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States.
score: 1.0425805, Antimicrobial agents and chemotherapy, 2009, Navon-Venezia, Shiri et. al.
Antibiotic susceptibility pattern of Mycobacterium marinum.
score: 1.0425776, Antimicrobial agents and chemotherapy, 2000, Aubry, A et. al.
MexAB-OprM- and MexXY-overproducing mutants are very prevalent among clinical strains of Pseudomonas aeruginosa with reduced susceptibility to ticarcillin.
score: 1.0425512, Antimicrobial agents and chemotherapy, 2007, Hocquet, Didier et. al.
Sequences of homologous beta-lactamases from clinical isolates of Serratia marcescens with different substrate specificities.
score: 1.0425377, Antimicrobial agents and chemotherapy, 1998, Matsumura, N; Minami, S; Mitsuhashi, S
Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells
score: 1.0424914, Bioorganic & Medicinal Chemistry Letters, 2012, Jespersen, Christine et. al.
Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells
score: 1.0424914, Bioorganic & Medicinal Chemistry Letters, 2012, Jespersen, Christine et. al.
Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells
score: 1.0424914, Bioorganic & Medicinal Chemistry Letters, 2012, Jespersen, Christine et. al.
Selection of a macaque Fab with framework regions like those in humans, high affinity, and ability to neutralize the protective antigen (PA) of Bacillus anthracis by binding to the segment of PA between residues 686 and 694.
score: 1.0424397, Antimicrobial agents and chemotherapy, 2005, Laffly, Emmanuelle et. al.
Selection and characterization of human monoclonal antibodies against Abrin by phage display
score: 1.0424171, Bioorganic & Medicinal Chemistry Letters, 2007, Zhou, Heyue et. al.
Penetration of moxifloxacin into peripheral compartments in humans.
score: 1.0423006, Antimicrobial agents and chemotherapy, 1999, Müller, M et. al.
In vitro synergistic effects of double and triple combinations of beta-lactams, vancomycin, and netilmicin against methicillin-resistant Staphylococcus aureus strains.
score: 1.0422985, Antimicrobial agents and chemotherapy, 2000, Rochon-Edouard, S; Pestel-Caron, M; Lemeland, J F; Caron, F
QSAR study on inhibition of brain 3-hydroxy-anthranilic acid dioxygenase (3-HAO): A molecular connectivity approach
score: 1.042277, Bioorganic & Medicinal Chemistry, 2001, Agrawal, Vijay K; Sohgaura, Rashmi; Khadikar, Padmakar V
Pharmacodynamic profiling of piperacillin in the presence of tazobactam in patients through the use of population pharmacokinetic models and Monte Carlo simulation.
score: 1.0422597, Antimicrobial agents and chemotherapy, 2004, Lodise, Thomas P et. al.
Synthesis of octadecylamine-retinoic acid conjugate for enhanced cytotoxic effects of 5-FU using LDL targeted nanostructured lipid carriers
score: 1.0422341, European Journal of Medicinal Chemistry, 2012, Varshosaz, Jaleh et. al.
Clinical and molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli causing bacteremia in the Rotterdam Area, Netherlands.
score: 1.0422182, Antimicrobial agents and chemotherapy, 2011, van der Bij, Akke K et. al.
Synthesis and solution conformation studies of the modified nucleoside N 4,2′- O-dimethylcytidine (m 4Cm) and its analogues
score: 1.0421922, Bioorganic & Medicinal Chemistry, 2008, Mahto, Santosh K.; Chow, Christine S.
Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
score: 1.042172, Antimicrobial agents and chemotherapy, 2000, Jalal, S; Ciofu, O; Hoiby, N; Gotoh, N; Wretlind, B
Efficacy of nitazoxanide against Cryptosporidium parvum in cell culture and in animal models.
score: 1.0421507, Antimicrobial agents and chemotherapy, 1998, Theodos, C M et. al.
Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies
score: 1.0421135, European Journal of Medicinal Chemistry, 2012, Mandal, Amitava et. al.
Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies
score: 1.0421135, European Journal of Medicinal Chemistry, 2012, Mandal, Amitava et. al.
Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies
score: 1.0421135, European Journal of Medicinal Chemistry, 2012, Mandal, Amitava et. al.
Cytotoxic activity and chemical reactivity of cis-platinum(II) and trans-palladium(II) complexes with diethyl (pyridinylmethyl)phosphates
score: 1.0420818, European Journal of Medicinal Chemistry, 2009, Kalinowska-Lis, Urszula et. al.
Interaction of bismuth subsalicylate with fruit juices, ascorbic acid, and thiol-containing substrates to produce soluble bismuth products active against Clostridium difficile.
score: 1.0420503, Antimicrobial agents and chemotherapy, 2005, Mahony, D E et. al.
Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols – Carbocyclic relatives of f-oxide-bridged phenylmorphans
score: 1.0420186, European Journal of Medicinal Chemistry, 2012, Li, Fuying et. al.
Lack of absorption of didanosine after rectal administration in human immunodeficiency virus-infected patients.
score: 1.0420009, Antimicrobial agents and chemotherapy, 1999, Wintergerst, U et. al.
Novel glycolipid TLR2 ligands of the type Pam2Cys-α-Gal: Synthesis and biological properties
score: 1.0419794, European Journal of Medicinal Chemistry, 2012, Thomann, Jean-Sébastien et. al.
Novel glycolipid TLR2 ligands of the type Pam2Cys-α-Gal: Synthesis and biological properties
score: 1.0419794, European Journal of Medicinal Chemistry, 2012, Thomann, Jean-Sébastien et. al.
Novel glycolipid TLR2 ligands of the type Pam2Cys-α-Gal: Synthesis and biological properties
score: 1.0419794, European Journal of Medicinal Chemistry, 2012, Thomann, Jean-Sébastien et. al.
Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.
score: 1.0418894, Antimicrobial agents and chemotherapy, 1999, Pelzer, S et. al.
Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor
score: 1.0418602, Bioorganic & Medicinal Chemistry, 2006, Miyata, Shohei et. al.
Polycationic peptides as prophylactic agents against methicillin-susceptible or methicillin-resistant Staphylococcus epidermidis vascular graft infection.
score: 1.0418476, Antimicrobial agents and chemotherapy, 2000, Giacometti, A et. al.
In vitro susceptibility of Coxiella burnetii to linezolid in comparison with its susceptibilities to quinolones, doxycycline, and clarithromycin.
score: 1.0418438, Antimicrobial agents and chemotherapy, 2001, Gikas, A et. al.
Efficacy of SCH27899 in an animal model of Legionnaires' disease using immunocompromised A/J mice.
score: 1.0418124, Antimicrobial agents and chemotherapy, 2000, Brieland, J K; Loebenberg, D; Menzel, F; Hare, R S
Synthesis and evaluation of [18F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)
score: 1.0418055, Bioorganic & Medicinal Chemistry, 2012, Nag, S. et. al.
Synthesis and evaluation of [18F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)
score: 1.0418055, Bioorganic & Medicinal Chemistry, 2012, Nag, S. et. al.
High affinity central benzodiazepine receptor ligands. Part 2: quantitative structure–activity relationships and comparative molecular field analysis of pyrazolo[4,3- c]quinolin-3-ones
score: 1.0417926, Bioorganic & Medicinal Chemistry, 2001, Savini, L. et. al.
In vitro activities of linezolid against important gram-positive bacterial pathogens including vancomycin-resistant enterococci.
score: 1.0417799, Antimicrobial agents and chemotherapy, 1999, Noskin, G A; Siddiqui, F; Stosor, V; Hacek, D; Peterson, L R
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
score: 1.0417248, Antimicrobial agents and chemotherapy, 2001, Yigit, H et. al.
Role of oxidative stress in persister tolerance.
score: 1.0416997, Antimicrobial agents and chemotherapy, 2012, Wu, Yanxia; Vulić, Marin; Keren, Iris; Lewis, Kim
Antimicrobial susceptibility of Shigella sonnei isolates in Japan and molecular analysis of S. sonnei isolates with reduced susceptibility to fluoroquinolones.
score: 1.0415731, Antimicrobial agents and chemotherapy, 2005, Hirose, Kenji et. al.
Pharmacokinetics of ciprofloxacin in the human eye: a clinical study and population pharmacokinetic analysis.
score: 1.0415654, Antimicrobial agents and chemotherapy, 2000, Morlet, N et. al.
Synthesis of photolabile transcription initiators and preparation of photocleavable functional RNA by transcription
score: 1.0415453, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Faqing; Shi, Yongliang
Synthesis of photolabile transcription initiators and preparation of photocleavable functional RNA by transcription
score: 1.0415453, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Faqing; Shi, Yongliang
Colonization and resistance dynamics of gram-negative bacteria in patients during and after hospitalization.
score: 1.0414295, Antimicrobial agents and chemotherapy, 2005, Filius, P Margreet G et. al.
Clarithromycin-resistant mycobacterium avium is still susceptible to treatment with clarithromycin and is virulent in mice.
score: 1.0413519, Antimicrobial agents and chemotherapy, 2000, Bermudez, L E et. al.
Conjugative plasmid conferring resistance to olaquindox.
score: 1.0413211, Antimicrobial agents and chemotherapy, 2003, Sørensen, Anders Hay et. al.
Novel conjugate of moxifloxacin and carboxymethylated glucan with enhanced activity against Mycobacterium tuberculosis.
score: 1.0412656, Antimicrobial agents and chemotherapy, 2006, Schwartz, Y S et. al.
Biological costs and mechanisms of fosfomycin resistance in Escherichia coli.
score: 1.041247, Antimicrobial agents and chemotherapy, 2003, Nilsson, Annika I et. al.
In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp.
score: 1.0412454, Antimicrobial agents and chemotherapy, 2005, Philip, Annie et. al.
In vitro activity of telithromycin (HMR3647), a new ketolide, against clinical isolates of Mycoplasma pneumoniae in Japan.
score: 1.0411293, Antimicrobial agents and chemotherapy, 2000, Yamaguchi, T et. al.
Lactoferrin inhibits Porphyromonas gingivalis proteinases and has sustained biofilm inhibitory activity.
score: 1.0410707, Antimicrobial agents and chemotherapy, 2012, Dashper, Stuart G et. al.
In vitro selection of hematoporphyrin binding DNA aptamers
score: 1.0409712, Bioorganic & Medicinal Chemistry Letters, 2000, Okazawa, Atsushi et. al.
QSAR models for Daphnia toxicity of pesticides based on combinations of topological parameters of molecular structures
score: 1.040971, Bioorganic & Medicinal Chemistry, 2006, Toropov, Andrey A.; Benfenati, Emilio
Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus.
score: 1.0409425, Antimicrobial agents and chemotherapy, 2001, Ito, T et. al.
Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureus.
score: 1.040908, Antimicrobial agents and chemotherapy, 2005, Reyes, Noe et. al.
Synthesis and antiviral activities of 1′-carbon-substituted 4′-thiothymidines
score: 1.0408673, Bioorganic & Medicinal Chemistry, 2004, Haraguchi, Kazuhiro et. al.
Molecular epidemiology of VIM-4 metallo-beta-lactamase-producing Pseudomonas sp. isolates in Hungary.
score: 1.0408387, Antimicrobial agents and chemotherapy, 2006, Libisch, Balázs et. al.
Antibiotic susceptibilities of 96 isolates of Bacillus anthracis isolated in France between 1994 and 2000.
score: 1.0407802, Antimicrobial agents and chemotherapy, 2002, Cavallo, Jean-Didier et. al.
Molecular characterization of FOX-4, a new AmpC-type plasmid-mediated beta-lactamase from an Escherichia coli strain isolated in Spain.
score: 1.0407765, Antimicrobial agents and chemotherapy, 2000, Bou, G; Oliver, A; Ojeda, M; Monzón, C; Martínez-Beltrán, J
Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease
score: 1.0407331, Bioorganic & Medicinal Chemistry, 2006, Ainge, Gary D. et. al.
DNA sequence analysis of DNA gyrase and DNA topoisomerase IV quinolone resistance-determining regions of Salmonella enterica serovar Typhi and serovar Paratyphi A.
score: 1.0407181, Antimicrobial agents and chemotherapy, 2002, Hirose, Kenji et. al.
Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women.
score: 1.040695, Antimicrobial agents and chemotherapy, 2012, Benaboud, Sihem et. al.
Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.
score: 1.0406674, Antimicrobial agents and chemotherapy, 2012, Endt, Kathrin et. al.
Hydroxy- or Methoxy-Substituted Benzaldoximes and Benzaldehyde- O-alkyloximes as Tyrosinase Inhibitors
score: 1.0406377, Bioorganic & Medicinal Chemistry, 2001, Ley, Jakob P; Bertram, Heinz-Jürgen
Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids.
score: 1.0405631, Antimicrobial agents and chemotherapy, 2003, Aliabadi, F Shojaee; Landoni, M F; Lees, P
In vitro activities of tritrpticin alone and in combination with other antimicrobial agents against Pseudomonas aeruginosa.
score: 1.0405565, Antimicrobial agents and chemotherapy, 2006, Cirioni, Oscar et. al.
Resistance to chloroquine unhinges vivax malaria therapeutics.
score: 1.0404877, Antimicrobial agents and chemotherapy, 2011, Baird, J Kevin
Synthesis and protein conjugation studies of vitamin K analogues
score: 1.040477, Bioorganic & Medicinal Chemistry, 2004, Payne, Richard J. et. al.
A new backbone of artificial enzymes obtained by cross-linkage of Poly(ethylenimine)
score: 1.0404674, Bioorganic & Medicinal Chemistry Letters, 1998, Suh, Junghun; Suk Noh, Young
Combination therapy of murine mucormycosis or aspergillosis with iron chelation, polyenes, and echinocandins.
score: 1.0404277, Antimicrobial agents and chemotherapy, 2011, Ibrahim, Ashraf S et. al.
Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir.
score: 1.040384, Antimicrobial agents and chemotherapy, 2004, Furfine, Eric S et. al.
Design and synthesis of a transition state analogue for the Diels–Alder reaction
score: 1.0402848, Bioorganic & Medicinal Chemistry, 1998, Arora, Paramjit S. et. al.
Synergistic activities of fluconazole and voriconazole with terbinafine against four Candida species determined by checkerboard, time-kill, and Etest methods.
score: 1.040165, Antimicrobial agents and chemotherapy, 2005, Cantón, Emilia et. al.
Efficient identification of human immunodeficiency virus type 1 mutants resistant to a protease inhibitor by using a random mutant library.
score: 1.0401243, Antimicrobial agents and chemotherapy, 2011, Kim, Sanggu et. al.
Cloning, sequencing, and functional analysis of an iterative type I polyketide synthase gene cluster for biosynthesis of the antitumor chlorinated polyenone neocarzilin in "Streptomyces carzinostaticus".
score: 1.0400754, Antimicrobial agents and chemotherapy, 2004, Otsuka, Miyuki; Ichinose, Koji; Fujii, Isao; Ebizuka, Yutaka
Antibiotic susceptibilities of Anaplasma (Ehrlichia) phagocytophilum strains from various geographic areas in the United States.
score: 1.0400558, Antimicrobial agents and chemotherapy, 2003, Maurin, Max; Bakken, Johan S; Dumler, J Stephen
In vitro hypersusceptibility of human immunodeficiency virus type 1 subtype C protease to lopinavir.
score: 1.0400498, Antimicrobial agents and chemotherapy, 2003, Gonzalez, Luis M F et. al.
Does long-term itraconazole prophylaxis result in in vitro azole resistance in mucosal Candida albicans isolates from persons with advanced human immunodeficiency virus infection? The National Institute of Allergy and Infectious Diseases Mycoses study group.
score: 1.0400385, Antimicrobial agents and chemotherapy, 2000, Goldman, M et. al.
Microbiological efficacy of levofloxacin for treatment of community-acquired pneumonia due to Chlamydia pneumoniae.
score: 1.0399215, Antimicrobial agents and chemotherapy, 2000, Hammerschlag, M R; Roblin, P M
Terpene trilactones from Gingko biloba: From ancient times to the 21st century
score: 1.039889, Bioorganic & Medicinal Chemistry, 2005, Nakanishi, Koji
Controlled trial of 3-day quinine-clindamycin treatment versus 7-day quinine treatment for adult travelers with uncomplicated falciparum malaria imported from the tropics.
score: 1.0398455, Antimicrobial agents and chemotherapy, 2001, Parola, P et. al.
In vitro mutagenicity of anti-inflammatory parsalmide analogues PA7, PA10, and PA31 triggered by biotransformation into hydroxy derivatives
score: 1.0398339, European Journal of Medicinal Chemistry, 2006, Cardoso, H.S. et. al.
2- O-Substituted Cyclodextrins as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide
score: 1.039823, Bioorganic & Medicinal Chemistry, 2002, Tarver, Gary J et. al.
PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.
score: 1.0398207, Antimicrobial agents and chemotherapy, 2012, Moskowitz, Samuel M et. al.
Macrolide resistance mediated by a Bifidobacterium breve membrane protein.
score: 1.0398076, Antimicrobial agents and chemotherapy, 2005, Margolles, Abelardo et. al.
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B
score: 1.0398076, European Journal of Medicinal Chemistry, 2012, Balaydın, Halis T. et. al.
Synthesis and pharmacological evaluation of novel cis-3,4-Diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor
score: 1.0397811, Bioorganic & Medicinal Chemistry, 2002, Bury, Paul S. et. al.
Diversity of tetracycline resistance genes in bacteria from Chilean salmon farms.
score: 1.039701, Antimicrobial agents and chemotherapy, 2003, Miranda, Claudio D et. al.
Mass-tag technology for monitoring of protein kinase activity using mass spectrometry
score: 1.0396851, Bioorganic & Medicinal Chemistry Letters, 2004, Sonoda, Tatsuhiko et. al.
From vanA Enterococcus hirae to vanA Enterococcus faecium: a study of feed supplementation with avoparcin and tylosin in young chickens.
score: 1.0396453, Antimicrobial agents and chemotherapy, 1999, Robredo, B; Singh, K V; Baquero, F; Murray, B E; Torres, C
Geographical and ecological analysis of resistance, coresistance, and coupled resistance to antimicrobials in respiratory pathogenic bacteria in Spain.
score: 1.0395391, Antimicrobial agents and chemotherapy, 2005, Pérez-Trallero, Emilio et. al.
Delivery of the non-membrane-permeative antibiotic gentamicin into mammalian cells by using Shigella flexneri membrane vesicles.
score: 1.0394867, Antimicrobial agents and chemotherapy, 1998, Kadurugamuwa, J L; Beveridge, T J
Comparative study of copper(II)–curcumin complexes as superoxide dismutase mimics and free radical scavengers
score: 1.0394613, European Journal of Medicinal Chemistry, 2007, Barik, Atanu et. al.
Antimicrobial resistance in Haemophilus influenzae isolated during population-based surveillance for meningitis in Salvador, Brazil.
score: 1.0393845, Antimicrobial agents and chemotherapy, 2002, Reis, Joice Neves et. al.
Pulsed ultrasound enhances the killing of Escherichia coli biofilms by aminoglycoside antibiotics in vivo.
score: 1.0393573, Antimicrobial agents and chemotherapy, 2000, Rediske, A M et. al.
Ultrasonic enhancement of antibiotic action on Escherichia coli biofilms: an in vivo model.
score: 1.0393573, Antimicrobial agents and chemotherapy, 1999, Rediske, A M et. al.
Molecular analysis of tetracycline resistance in Pasteurella aerogenes.
score: 1.0392607, Antimicrobial agents and chemotherapy, 2001, Kehrenberg, C; Schwarz, S
Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.
score: 1.0392544, Antimicrobial agents and chemotherapy, 2012, Søndergaard, Annette et. al.
The ybxI gene of Bacillus subtilis 168 encodes a class D beta-lactamase of low activity.
score: 1.0391224, Antimicrobial agents and chemotherapy, 2004, Colombo, Maria-Luigi et. al.
Synthesis and pharmacokinetic profile of a quaternary ammonium derivative of chlorambucil, a potential anticancer drug for the chemotherapy of chondrosarcoma
score: 1.0390661, Bioorganic & Medicinal Chemistry, 2003, Rapp, Maryse et. al.
Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy
score: 1.0390537, Bioorganic & Medicinal Chemistry, 2012, Gardner, Christopher R. et. al.
Importance of species selection in arrythmogenic models of Q-T interval prolongation.
score: 1.0390418, Antimicrobial agents and chemotherapy, 2002, McDermott, Jeff S et. al.
Solid phase synthesis of [ 18F]Labelled peptides for positron emission tomography
score: 1.0389928, Bioorganic & Medicinal Chemistry Letters, 2000, Sutcliffe-Goulden, Julie L et. al.
Expression of the mef(E) gene encoding the macrolide efflux pump protein increases in Streptococcus pneumoniae with increasing resistance to macrolides.
score: 1.0389716, Antimicrobial agents and chemotherapy, 2005, Wierzbowski, Aleksandra K et. al.
Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria.
score: 1.0389426, Antimicrobial agents and chemotherapy, 2002, Nealon, Claire et. al.
Large conjugative plasmids from clinical strains of Salmonella enterica serovar virchow contain a class 2 integron in addition to class 1 integrons and several non-integron-associated drug resistance determinants.
score: 1.0389115, Antimicrobial agents and chemotherapy, 2006, Rodríguez, Irene et. al.
Dried blood spot analysis for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis.
score: 1.0388833, Antimicrobial agents and chemotherapy, 2012, Vu, D H et. al.
Steroidal saponins from Calamus insignis, and their cell growth and cell cycle inhibitory activities
score: 1.0388671, Bioorganic & Medicinal Chemistry, 2006, Ohtsuki, Takashi et. al.
α-Glucopyranoimidazolines as intermediate analogue inhibitors of family 20 β- N-acetylglucosaminidases
score: 1.0388347, Bioorganic & Medicinal Chemistry, 2005, Kato, Masahiro; Uno, Tetsuya; Hiratake, Jun; Sakata, Kanzo
Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues
score: 1.0388227, Bioorganic & Medicinal Chemistry, 2005, Evers, Britta et. al.
Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro.
score: 1.0387948, Antimicrobial agents and chemotherapy, 2002, Balestrieri, Emanuela et. al.
Glucocorticoids increase in vitro and in vivo activities of antibiotics against Chlamydophila pneumoniae.
score: 1.0387405, Antimicrobial agents and chemotherapy, 2004, Caronzolo, Dario et. al.
Use of different inhibitory quotients to predict early virological response to tipranavir in antiretroviral-experienced human immunodeficiency virus-infected patients.
score: 1.0386437, Antimicrobial agents and chemotherapy, 2009, Morello, Judit et. al.
Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania.
score: 1.0386157, Antimicrobial agents and chemotherapy, 2003, Pearce, Richard J et. al.
Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: identification of gyrA and parC and specification of point mutations associated with resistance.
score: 1.038601, Antimicrobial agents and chemotherapy, 2000, Yan, S S et. al.
Host mutations (miaA and rpsL) reduce tetracycline resistance mediated by Tet(O) and Tet(M).
score: 1.0385924, Antimicrobial agents and chemotherapy, 1998, Taylor, D E; Trieber, C A; Trescher, G; Bekkering, M
Efficacy of NS-718, a novel lipid nanosphere-encapsulated amphotericin B, against Cryptococcus neoformans.
score: 1.0385685, Antimicrobial agents and chemotherapy, 1998, Hossain, M A et. al.
PCR-based ordered genomic libraries: a new approach to drug target identification for Streptococcus pneumoniae.
score: 1.0385612, Antimicrobial agents and chemotherapy, 2002, Belanger, Aimee E et. al.
Can Etest be used to determine Vibrio cholerae susceptibility to erythromycin?
score: 1.0385295, Antimicrobial agents and chemotherapy, 2003, Ng, Lai-King et. al.
ErmB determinants and Tn916-Like elements in clinical isolates of Clostridium difficile.
score: 1.0385295, Antimicrobial agents and chemotherapy, 2005, Spigaglia, Patrizia et. al.
Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis.
score: 1.0384539, Antimicrobial agents and chemotherapy, 2001, Dietze, R et. al.
Concentration-dependent selection of small phenotypic differences in TEM beta-lactamase-mediated antibiotic resistance.
score: 1.0383486, Antimicrobial agents and chemotherapy, 2000, Negri, M C; Lipsitch, M; Blázquez, J; Levin, B R; Baquero, F
Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1,4-di- N-oxide derivatives as anti- Mycobacterium tuberculosis agents
score: 1.0383465, European Journal of Medicinal Chemistry, 2003, Jaso, Andrés et. al.
Synthesis and structure–affinity relationship investigations of 5-aminomethyl and 5-carbamoyl analogues of the antipsychotic sertindole. A new class of selective α 1 adrenoceptor antagonists
score: 1.0383015, Bioorganic & Medicinal Chemistry, 2003, Balle, Thomas et. al.
Synthesis and evaluation of oligo-1,3-thiazolecarboxamide derivatives as HIV-1 reverse transcriptase inhibitors
score: 1.0381923, Bioorganic & Medicinal Chemistry, 2000, Ryabinin, Vladimir A. et. al.
Correlation of the MIC and dose/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemia.
score: 1.0381841, Antimicrobial agents and chemotherapy, 2007, Rodríguez-Tudela, Juan L et. al.
Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007.
score: 1.0381828, Antimicrobial agents and chemotherapy, 2011, Castanheira, Mariana et. al.
Phenotypic distinction in Enterococcus faecium and Enterococcus faecalis strains between susceptibility and resistance to growth-enhancing antibiotics.
score: 1.0381676, Antimicrobial agents and chemotherapy, 1999, Butaye, P; Devriese, L A; Haesebrouck, F
Effect of cell-photosensitizer binding and cell density on microbial photoinactivation.
score: 1.0381538, Antimicrobial agents and chemotherapy, 2005, Demidova, Tatiana N; Hamblin, Michael R
QSAR by LFER model of HIV protease inhibitor mannitol derivatives using FA-MLR, PCRA, and PLS techniques
score: 1.0379651, Bioorganic & Medicinal Chemistry, 2006, Leonard, J. Thomas; Roy, Kunal
Using hydroxymethylphenoxy derivates with the SPOT technology to generate peptides with authentic C-termini
score: 1.037917, Bioorganic & Medicinal Chemistry Letters, 2008, Ay, Bernhard et. al.
Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes
score: 1.037902, European Journal of Medicinal Chemistry, 2010, Melo Pereira, José Clayston et. al.
Toxicity mechanisms of amphotericin B and its neutralization by conjugation with arabinogalactan.
score: 1.0378722, Antimicrobial agents and chemotherapy, 2012, Kagan, Sarah et. al.
Development of TNKase-specific cleavable peptide-linked radioimmunoconjugates for radioimmunotherapy
score: 1.037849, Bioorganic & Medicinal Chemistry Letters, 2008, Natarajan, Arutselvan et. al.
Clindamycin suppresses endotoxin released by ceftazidime-treated Escherichia coli O55:B5 and subsequent production of tumor necrosis factor alpha and interleukin-1 beta.
score: 1.0377853, Antimicrobial agents and chemotherapy, 1999, Kishi, K; Hirai, K; Hiramatsu, K; Yamasaki, T; Nasu, M
Pharmacokinetic profiles of ceftazidime after intravenous administration in patients undergoing automated peritoneal dialysis.
score: 1.0377624, Antimicrobial agents and chemotherapy, 2011, Kim, Kiwon et. al.
Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases.
score: 1.0376994, Antimicrobial agents and chemotherapy, 2011, Scotta, Claudia et. al.
Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones
score: 1.0376991, Bioorganic & Medicinal Chemistry, 2001, Mukherjee, Shubhasish et. al.
Antitumor agents. Part 209: Pheophorbide- a derivatives as photo-Independent cytotoxic agents
score: 1.0376743, Bioorganic & Medicinal Chemistry, 2002, Wongsinkongman, Prapai et. al.
Treatment of tuberculosis using a combination of sustained-release rifampin-loaded microspheres and oral dosing with isoniazid.
score: 1.0376513, Antimicrobial agents and chemotherapy, 2001, Quenelle, D C et. al.
Pharmacokinetics of itraconazole in diabetic rats.
score: 1.0376436, Antimicrobial agents and chemotherapy, 2010, Lee, Unji; Choi, Young H; Kim, So H; Lee, Byung K
Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines.
score: 1.037587, Antimicrobial agents and chemotherapy, 2004, Weiss, Taly et. al.
Comparison of methods to test antibiotic combinations against heterogeneous populations of multiresistant Pseudomonas aeruginosa from patients with acute infective exacerbations in cystic fibrosis.
score: 1.0375694, Antimicrobial agents and chemotherapy, 2009, Foweraker, Juliet E et. al.
New multiplex PCR for rapid detection of isoniazid-resistant Mycobacterium tuberculosis clinical isolates.
score: 1.0374658, Antimicrobial agents and chemotherapy, 2005, Herrera-León, Laura et. al.
Effect of linezolid in comparison with that of vancomycin on glycocalix production: in vitro study.
score: 1.037428, Antimicrobial agents and chemotherapy, 2002, Drago, L; De Vecchi, E; Valli, M; Nicola, L; Gismondo, M R
Single-dose safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, in HIV-infected children.
score: 1.0373992, Antimicrobial agents and chemotherapy, 2005, Yogev, Ram et. al.
Electrochemiluminescence determination of pipemidic acid using sulfite as energy transfer mediator
score: 1.0373899, Bioorganic & Medicinal Chemistry Letters, 2006, Liang, Yao-Dong; Gao, Wei; Song, Jun-Feng
Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model.
score: 1.0373046, Antimicrobial agents and chemotherapy, 1998, Sawa, T et. al.
Heterocycle-functional gramine analogues: Solvent and catalyst-free synthesis and their inhibition activities against cell proliferation
score: 1.0372194, European Journal of Medicinal Chemistry, 2012, Ke, Shaoyong et. al.
First VanD-Type vancomycin-resistant Enterococcus raffinosus isolate.
score: 1.0372184, Antimicrobial agents and chemotherapy, 2006, Tanimoto, Koichi et. al.
Caz-hi, and extended-spectrum TEM beta-lactamase (TEM-61), is derived from Caz-lo (TEM-11) by in vivo selection.
score: 1.0372184, Antimicrobial agents and chemotherapy, 1998, Claeys Geert, et. al.
Nucleotide sequence of IS1678, an insertion sequence in the vanA cluster of enterococci.
score: 1.0372184, Antimicrobial agents and chemotherapy, 2005, Jung, Woo Kyung et. al.
Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species
score: 1.0371586, Bioorganic & Medicinal Chemistry Letters, 2010, Xu, Wei; Huang, Han-chang; Lin, Chang-jun; Jiang, Zhao-Feng
In vitro activities of a novel nanoemulsion against Burkholderia and other multidrug-resistant cystic fibrosis-associated bacterial species.
score: 1.0371021, Antimicrobial agents and chemotherapy, 2009, LiPuma, John J et. al.
Clonal dissemination of a CTX-M-15 beta-lactamase-producing Escherichia coli strain in the Paris area, Tunis, and Bangui.
score: 1.0370769, Antimicrobial agents and chemotherapy, 2006, Lavollay, M et. al.
Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing.
score: 1.0369852, Antimicrobial agents and chemotherapy, 1999, Lipman, J; Wallis, S C; Rickard, C
Influence of soil use on prevalence of tetracycline, streptomycin, and erythromycin resistance and associated resistance genes.
score: 1.0368657, Antimicrobial agents and chemotherapy, 2012, Popowska, Magdalena et. al.
Expressed and unexpressed tet(M) genes and the erm(B)-carrying Tn1116 transposon in Streptococcus pyogenes and Streptococcus pneumoniae.
score: 1.0367705, Antimicrobial agents and chemotherapy, 2007, Giovanetti, E et. al.
High-level resistance to fluoroquinolones linked to mutations in gyrA, parC, and parE in Salmonella enterica serovar Schwarzengrund isolates from humans in Taiwan.
score: 1.0367705, Antimicrobial agents and chemotherapy, 2005, Baucheron, Sylvie et. al.
Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women.
score: 1.0367428, Antimicrobial agents and chemotherapy, 2012, Benaboud, Sihem et. al.
Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6.
score: 1.0367046, Antimicrobial agents and chemotherapy, 2012, Lamoureaux, Toni L et. al.
Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms.
score: 1.0366877, Antimicrobial agents and chemotherapy, 2001, De Kievit, T R et. al.
Imidazothiadiazine dioxides: synthesis and antiviral activity
score: 1.0366606, Bioorganic & Medicinal Chemistry, 1999, Martı́nez, Ana et. al.
Synthesis and human NKT cell stimulating properties of 3- O-sulfo-α/β-galactosylceramides
score: 1.0366104, Bioorganic & Medicinal Chemistry, 2005, Xing, Guo-Wen et. al.
Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract.
score: 1.0366091, Antimicrobial agents and chemotherapy, 2004, Donskey, Curtis J et. al.
Antibacterial activity of aminoderivatized chitosans against methicillin-resistant Staphylococcus aureus (MRSA)
score: 1.0365963, Bioorganic & Medicinal Chemistry, 2009, Lee, Dae-Sung et. al.
Isocratic high-performance liquid chromatographic method with ultraviolet detection for simultaneous determination of levels of voriconazole and itraconazole and its hydroxy metabolite in human serum.
score: 1.0365944, Antimicrobial agents and chemotherapy, 2005, Khoschsorur, GholamAli; Fruehwirth, Franz; Zelzer, Sieglinde
Fluoroquinolone-resistant Streptococcus pneumoniae in Spain: activities of garenoxacin against clinical isolates including strains with altered topoisomerases.
score: 1.0365868, Antimicrobial agents and chemotherapy, 2003, Morosini, María-Isabel et. al.
Mutation analysis of the Mycobacterium leprae folP1 gene and dapsone resistance.
score: 1.0365803, Antimicrobial agents and chemotherapy, 2011, Nakata, Noboru; Kai, Masanori; Makino, Masahiko
Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins
score: 1.0365416, Bioorganic & Medicinal Chemistry Letters, 2004, Kindermann, Maik; Sielaff, India; Johnsson, Kai
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine
score: 1.0365275, Bioorganic & Medicinal Chemistry Letters, 2004, Mazier, Claire et. al.
Occurrence of newer beta-lactamases in Klebsiella pneumoniae isolates from 24 U.S. hospitals.
score: 1.0365081, Antimicrobial agents and chemotherapy, 2002, Moland, Ellen Smith et. al.
Wild coastline birds as reservoirs of broad-spectrum-β-lactamase-producing Enterobacteriaceae in Miami Beach, Florida.
score: 1.0364998, Antimicrobial agents and chemotherapy, 2012, Poirel, Laurent et. al.
Discovery of CTX-M-like extended-spectrum beta-lactamases in Escherichia coli isolates from five US States.
score: 1.0364718, Antimicrobial agents and chemotherapy, 2003, Moland, E Smith et. al.
RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation.
score: 1.0364296, Antimicrobial agents and chemotherapy, 2007, Anguita-Alonso, Paloma et. al.
Differential effects of levofloxacin and ciprofloxacin on the risk for isolation of quinolone-resistant Pseudomonas aeruginosa.
score: 1.0364132, Antimicrobial agents and chemotherapy, 2006, Kaye, Keith S et. al.
Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.
score: 1.0363703, Antimicrobial agents and chemotherapy, 2001, Garcia-Calvo, G et. al.
(+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase
score: 1.0363552, Bioorganic & Medicinal Chemistry Letters, 2012, Wikul, Arin et. al.
Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages.
score: 1.0363387, Antimicrobial agents and chemotherapy, 2006, Mookerjee Basu, Jayati et. al.
Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes.
score: 1.0363065, Antimicrobial agents and chemotherapy, 1999, Bourne, N; Bernstein, D I; Stanberry, L R
ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae.
score: 1.0363045, Antimicrobial agents and chemotherapy, 1999, Varon, E; Janoir, C; Kitzis, M D; Gutmann, L
Presence of lamivudine or emtricitabine is associated with reduced emergence of nonnucleoside reverse transcriptase inhibitor mutations in an efavirenz-based intermittent antiretroviral treatment regimen.
score: 1.036292, Antimicrobial agents and chemotherapy, 2012, Trancart, Stéphanie et. al.
Preparation and optimization of PIT solid lipid nanoparticles via statistical factorial design
score: 1.0362311, European Journal of Medicinal Chemistry, 2012, Carbone, C. et. al.
Combination therapy with intravenous colistin for management of infections due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosis.
score: 1.0362233, Antimicrobial agents and chemotherapy, 2005, Kasiakou, Sofia K et. al.
Need for annual surveillance of antimicrobial resistance in Streptococcus pneumoniae in the United States: 2-year longitudinal analysis.
score: 1.0362169, Antimicrobial agents and chemotherapy, 2001, Sahm, D F et. al.
Synthesis of friedelan triterpenoid analogues with DNA topoisomerase IIα inhibitory activity and their molecular docking studies
score: 1.0362073, European Journal of Medicinal Chemistry, 2012, Mandal, Amitava et. al.
Risk factors for development of multiple-class resistance to Streptococcus pneumoniae Strains in Belgium over a 10-year period: antimicrobial consumption, population density, and geographic location.
score: 1.036197, Antimicrobial agents and chemotherapy, 2007, Van Eldere, Johan et. al.
New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714
score: 1.0361843, European Journal of Medicinal Chemistry, 2012, Pozo-Rodrigálvarez, Andrea et. al.
New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714
score: 1.0361843, European Journal of Medicinal Chemistry, 2012, Pozo-Rodrigálvarez, Andrea et. al.
Effects of MS-8209, an amphotericin B derivative, on tumor necrosis factor alpha synthesis and human immunodeficiency virus replication in macrophages.
score: 1.036098, Antimicrobial agents and chemotherapy, 2000, Clayette, P et. al.
Mechanism of bactericidal activity of microcin L in Escherichia coli and Salmonella enterica.
score: 1.0360978, Antimicrobial agents and chemotherapy, 2011, Morin, Natacha et. al.
Molecular characterization of glycopeptide-resistant Enterococcus faecium isolates from Portuguese hospitals.
score: 1.0360298, Antimicrobial agents and chemotherapy, 2005, Novais, Carla et. al.
Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity.
score: 1.036002, Antimicrobial agents and chemotherapy, 2006, Bayer, A S et. al.
7,8-Dihydropterin-6-carboxylic acid as light emitter of luminous millipede, Luminodesmus sequoiae
score: 1.0358685, Bioorganic & Medicinal Chemistry Letters, 2001, Kuse, Masaki et. al.
Postantibiotic effects of gatifloxacin against gram-positive and -negative organisms.
score: 1.0358442, Antimicrobial agents and chemotherapy, 1999, Pankuch, G A; Jacobs, M R; Appelbaum, P C
Antifungal combinations against simulated Candida albicans endocardial vegetations.
score: 1.0358342, Antimicrobial agents and chemotherapy, 2009, Pai, Manjunath P
Role of P-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier.
score: 1.0358047, Antimicrobial agents and chemotherapy, 2005, Edwards, Jeffrey E et. al.
Synthesis and in vitro antibacterial activity of novel heterocyclic derivatives of 18-nor-equilenin
score: 1.0357057, European Journal of Medicinal Chemistry, 2006, Karnik, A.V.; Malviya, N.J.; Kulkarni, A.M.; Jadhav, B.L.
Modulation of immunostimulatory activity of CpG oligonucleotides by site-Specific deletion of nucleobases
score: 1.0356704, Bioorganic & Medicinal Chemistry Letters, 2001, Yu, Dong et. al.
New species genetic approach to identify strains of mitis group streptococci that are donors of rifampin resistance to Streptococcus pneumoniae.
score: 1.0356281, Antimicrobial agents and chemotherapy, 2011, Ferrándiz, María-José et. al.
Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.
score: 1.0356077, Antimicrobial agents and chemotherapy, 2000, Kern, W V; Oethinger, M; Jellen-Ritter, A S; Levy, S B
Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity
score: 1.0354775, Bioorganic & Medicinal Chemistry, 1999, Karle, Jean M.; Bhattacharjee, Apurba K.
Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.
score: 1.0354003, Antimicrobial agents and chemotherapy, 2004, Doi, Yohei et. al.
Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence.
score: 1.0353739, Antimicrobial agents and chemotherapy, 2012, Lister, Ida M; Raftery, Connor; Mecsas, Joan; Levy, Stuart B
In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates.
score: 1.0353722, Antimicrobial agents and chemotherapy, 2002, Meletiadis, Joseph et. al.
Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach.
score: 1.0353118, Antimicrobial agents and chemotherapy, 2011, Park, Kwang Seung et. al.
Decreased susceptibility to noncarbapenem antimicrobials in extended-spectrum-β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates in Toronto, Canada.
score: 1.0352573, Antimicrobial agents and chemotherapy, 2012, Lowe, Christopher F et. al.
Slow reversible inhibitions of rabbit muscle aldolase with substrate analogues: synthesis, enzymatic kinetics and UV difference spectroscopy studies
score: 1.0351409, Bioorganic & Medicinal Chemistry, 1996, Gefflaut, T.; Blonski, C.; Périé, J.
Inhibition of Staphylococcus epidermidis Biofilm by Trimethylsilane Plasma Coating.
score: 1.0351165, Antimicrobial agents and chemotherapy, 2012, Ma, Yibao et. al.
Cancer cell specific gene delivery by laminin-derived peptide AG73-labeled liposomes
score: 1.0350998, Bioorganic & Medicinal Chemistry Letters, 2010, Iijima, Hiroshi et. al.
Synthesis and properties of triplex-forming oligonucleotides containing 2′- O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine
score: 1.0350622, Bioorganic & Medicinal Chemistry, 2010, Lou, Chenguang et. al.
Antimicrobial stewardship lessons: do Pseudomonas-sparing agents, such as ertapenem, effectively improve bacterial resistance?
score: 1.0349799, Antimicrobial agents and chemotherapy, 2010, dos Santos, Rodrigo Pires et. al.
Successful treatment with nitazoxanide of Enterocytozoon bieneusi microsporidiosis in a patient with AIDS.
score: 1.0349408, Antimicrobial agents and chemotherapy, 2000, Bicart-Sée, A; Massip, P; Linas, M D; Datry, A
Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain.
score: 1.0349384, Antimicrobial agents and chemotherapy, 2006, Xie, Hua et. al.
The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.
score: 1.0348919, Antimicrobial agents and chemotherapy, 2012, Duan, Jianmin et. al.
Effects of antibiotics on Shiga toxin 2 production and bacteriophage induction by epidemic Escherichia coli O104:H4 strain.
score: 1.0348571, Antimicrobial agents and chemotherapy, 2012, Bielaszewska, Martina et. al.
In vitro activities of ravuconazole and voriconazole compared with those of four approved systemic antifungal agents against 6,970 clinical isolates of Candida spp.
score: 1.0347952, Antimicrobial agents and chemotherapy, 2002, Pfaller, M A et. al.
High variability of plasma drug concentrations in dual protease inhibitor regimens.
score: 1.0347913, Antimicrobial agents and chemotherapy, 2003, Guiard-Schmid, Jean-Baptiste et. al.
Zanamivir, at 600 milligrams twice daily, inhibits oseltamivir-resistant 2009 pandemic H1N1 influenza virus in an in vitro hollow-fiber infection model system.
score: 1.0347812, Antimicrobial agents and chemotherapy, 2011, Brown, Ashley N et. al.
In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae.
score: 1.0347149, Antimicrobial agents and chemotherapy, 1999, Davies, T A et. al.
Flow cytometric determination of the effects of antibacterial agents on Mycoplasma agalactiae, Mycoplasma putrefaciens, Mycoplasma capricolum subsp. capricolum, and Mycoplasma mycoides subsp. mycoides large colony type.
score: 1.034632, Antimicrobial agents and chemotherapy, 2006, Assunção, Patricia et. al.
Genes required for intrinsic multidrug resistance in Mycobacterium avium.
score: 1.0346225, Antimicrobial agents and chemotherapy, 2004, Philalay, Julie S et. al.
SSR182289A, a selective and potent orally active thrombin inhibitor
score: 1.0345607, Bioorganic & Medicinal Chemistry, 2004, Altenburger, Jean-Michel et. al.
Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.
score: 1.0344943, Antimicrobial agents and chemotherapy, 2003, Bermudez, Luiz E et. al.
Isolation of brominated quinones showing chemiluminescence activity from luminous acorn worm, Ptychodera flava
score: 1.0344684, Bioorganic & Medicinal Chemistry, 2005, Kanakubo, Akira; Isobe, Minoru
Reduced azole susceptibility in genotype 3 Candida dubliniensis isolates associated with increased CdCDR1 and CdCDR2 expression.
score: 1.0344529, Antimicrobial agents and chemotherapy, 2005, Pinjon, Emmanuelle et. al.
Interaction of Streptococcus pneumoniae and Moraxella catarrhalis: investigation of the indirect pathogenic role of beta-lactamase-producing moraxellae by use of a continuous-culture biofilm system.
score: 1.0344521, Antimicrobial agents and chemotherapy, 1998, Budhani, R K; Struthers, J K
Phase II, randomized, multicenter, double-blind, placebo-controlled trial of a polyclonal anti-Staphylococcus aureus capsular polysaccharide immune globulin in treatment of Staphylococcus aureus bacteremia.
score: 1.034447, Antimicrobial agents and chemotherapy, 2007, Rupp, Mark E et. al.
The structural gene for microcin H47 encodes a peptide precursor with antibiotic activity.
score: 1.0344304, Antimicrobial agents and chemotherapy, 1999, Rodríguez, E; Gaggero, C; Laviña, M
Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site
score: 1.034414, Bioorganic & Medicinal Chemistry, 2006, Hampson, Laura J. et. al.
Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide
score: 1.0343952, Bioorganic & Medicinal Chemistry Letters, 2003, Higgin, Joshua J et. al.
A Convenient Synthesis of Δ 7,8-Morphinan-6-one and Its Direct Oxidation to 14-Hydroxy-Δ 7,8-morphinan-6-one
score: 1.0343904, Bioorganic & Medicinal Chemistry Letters, 2002, Passarella, Daniele et. al.
Structure–activity relationships of acyloxyamidine cytomegalovirus DNA polymerase inhibitors
score: 1.034382, Bioorganic & Medicinal Chemistry, 2000, Tucker, John A. et. al.
Simple fibroblast-based assay to test the pyrazinamide susceptibility of Mycobacterium tuberculosis.
score: 1.034367, Antimicrobial agents and chemotherapy, 2005, Takii, Takemasa et. al.
Short and efficient syntheses of analogues of way-100635: new and potent 5-HT 1A receptor antagonists
score: 1.0343456, Bioorganic & Medicinal Chemistry, 2001, Marchais, Sandrine et. al.
Salmonella excretion after cessation of tosufloxacin therapy in acute nontyphoid salmonella enterocolitis.
score: 1.0343373, Antimicrobial agents and chemotherapy, 2001, Ohnishi, K; Kimura, K
Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains
score: 1.034319, Bioorganic & Medicinal Chemistry Letters, 2004, Qian, Xuhong et. al.
Synthesis of tools for target identification of the anti-apoptotic compound CGP 3466; Part I
score: 1.0343147, Bioorganic & Medicinal Chemistry Letters, 1998, Zimmermann, Kaspar et. al.
A population pharmacokinetic analysis of nelfinavir mesylate in human immunodeficiency virus-infected patients enrolled in a phase III clinical trial.
score: 1.0343076, Antimicrobial agents and chemotherapy, 2000, Jackson, K A et. al.
Epidemic clonal groups of Escherichia coli as a cause of antimicrobial-resistant urinary tract infections in Canada, 2002 to 2004.
score: 1.0342786, Antimicrobial agents and chemotherapy, 2009, Johnson, James R et. al.
Efficient asymmetric syntheses, determination of absolute configurations and biological activities of 1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine as a novel potent dopamine uptake inhibitor in the central nervous system
score: 1.0341595, Bioorganic & Medicinal Chemistry, 2004, Kimura, Makoto et. al.
Characterization of passage-selected vancomycin-resistant Staphylococcus aureus strains of diverse parental backgrounds.
score: 1.0341101, Antimicrobial agents and chemotherapy, 2000, Pfeltz, R F et. al.
Thermodynamic quantitative structure–activity relationship analysis for enzyme–ligand interactions in aqueous phosphate buffer and organic solvent
score: 1.0341098, Bioorganic & Medicinal Chemistry, 2001, Kim, Ki Hwan
Clinical isolation and resistance patterns of and superinfection with 10 nosocomial pathogens after treatment with ceftriaxone versus ampicillin-sulbactam.
score: 1.0340873, Antimicrobial agents and chemotherapy, 2001, Carmeli, Y; Castro, J; Eliopoulos, G M; Samore, M H
Use of inverse PCR for analysis of class 1 integrons carrying an unusual 3' conserved segment structure.
score: 1.0340827, Antimicrobial agents and chemotherapy, 2011, Lee, Mei-Feng et. al.
Synthesis of new pyrrolo[1,2- d][1,2,4]triazines and thiazolo[3,4- d][1,2,4]triazines as immunostimulating agents
score: 1.0340261, Bioorganic & Medicinal Chemistry, 1998, Issartel, Véronique et. al.
Novel beta-lactamase genes from two environmental isolates of Vibrio harveyi.
score: 1.0340233, Antimicrobial agents and chemotherapy, 2000, Teo, J W; Suwanto, A; Poh, C L
mecA-blaZ corepressors in clinical Staphylococcus aureus isolates.
score: 1.034017, Antimicrobial agents and chemotherapy, 2003, Rosato, Adriana E et. al.
Standardization of an experimental murine model of invasive pulmonary aspergillosis.
score: 1.0340001, Antimicrobial agents and chemotherapy, 2006, Sheppard, Donald C et. al.
Virulence genotype and phylogenetic origin in relation to antibiotic resistance profile among Escherichia coli urine sample isolates from Israeli women with acute uncomplicated cystitis.
score: 1.0339786, Antimicrobial agents and chemotherapy, 2005, Johnson, James R et. al.
Influence of empiric therapy with a beta-lactam alone or combined with an aminoglycoside on prognosis of bacteremia due to gram-negative microorganisms.
score: 1.0339599, Antimicrobial agents and chemotherapy, 2010, Martínez, J A et. al.
Synthesis and antitumor activity of 20- O-linked nitrogen-based camptothecin ester derivatives
score: 1.0339536, Bioorganic & Medicinal Chemistry, 2004, Wang, Cun-ying et. al.
Synergy testing of vancomycin-resistant Enterococcus faecium against quinupristin-dalfopristin in combination with other antimicrobial agents.
score: 1.0339503, Antimicrobial agents and chemotherapy, 1999, Matsumura, S O; Louie, L; Louie, M; Simor, A E
Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter.
score: 1.0338473, Antimicrobial agents and chemotherapy, 2003, Noël, Thierry et. al.
Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions.
score: 1.0337426, Antimicrobial agents and chemotherapy, 2007, Kondo, Yoko et. al.
Kinetic and mechanistic investigations on reductions of aflatoxins by lactic acid
score: 1.0336966, Bioorganic & Medicinal Chemistry Letters, 2002, Shukla, Ram S.; Verma, Ramtej J.; Mehta, Daxa N.
Bimetallic complexes constructed from asymmetrical N,N′-bis(substituted)-oxamide: Cytotoxicities, and reactivities towards DNA and protein
score: 1.0336435, European Journal of Medicinal Chemistry, 2012, Li, Xiao-Wen et. al.
Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis.
score: 1.0336415, Antimicrobial agents and chemotherapy, 2011, Carrillo-Muñoz, Alfonso J et. al.
Sex attractant pheromone of the pecan nut casebearer (Lepidoptera: Pyralidae)
score: 1.0336387, Bioorganic & Medicinal Chemistry, 1996, Millar, Jocelyn G. et. al.
Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro.
score: 1.0336123, Antimicrobial agents and chemotherapy, 2011, Adesse, Daniel et. al.
Antifungal therapy in an athymic murine model of chromoblastomycosis by Fonsecaea pedrosoi.
score: 1.0335995, Antimicrobial agents and chemotherapy, 2011, Calvo, Enrique et. al.
Cysteine based novel noncompetitive inhibitors of urease(s)—Distinctive inhibition susceptibility of microbial and plant ureases
score: 1.0335383, Bioorganic & Medicinal Chemistry, 2006, Amtul, Zareen et. al.
Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT4 receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation
score: 1.0334712, Bioorganic & Medicinal Chemistry Letters, 2012, Long, Daniel D. et. al.
Efficacy of ampicillin plus arbekacin in experimental rabbit endocarditis caused by an Enterococcus faecalis strain with high-level gentamicin resistance.
score: 1.0334515, Antimicrobial agents and chemotherapy, 2000, Kak, V et. al.
The macrolide efflux genetic assembly of Streptococcus pneumoniae is present in erythromycin-resistant Streptococcus salivarius.
score: 1.0333749, Antimicrobial agents and chemotherapy, 2002, Stadler, Christina; Teuber, Michael
Reinterpretation of susceptibility data using current NCCLS breakpoint criteria.
score: 1.0333749, Antimicrobial agents and chemotherapy, 2003, Jones, Mark E et. al.
Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004.
score: 1.0333583, Antimicrobial agents and chemotherapy, 2006, Guthmann, Jean-Paul et. al.
First report of the metallo-beta-lactamase SPM-1 in Europe.
score: 1.0333489, Antimicrobial agents and chemotherapy, 2010, Salabi, Allaaeddin El et. al.
Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties
score: 1.0332755, Bioorganic & Medicinal Chemistry, 2006, Barsoum, Flora F.; Hosni, Hanaa M.; Girgis, Adel S.
9-Deaza-5′-noraristeromycin
score: 1.0332643, Bioorganic & Medicinal Chemistry, 2003, Tuncbilek, Meral; Schneller, Stewart W
Efficacy of micafungin in combination with other drugs in a murine model of disseminated trichosporonosis.
score: 1.0331593, Antimicrobial agents and chemotherapy, 2005, Serena, Carolina et. al.
Clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin-resistant Staphylococcus aureus bloodstream infections.
score: 1.0331144, Antimicrobial agents and chemotherapy, 2011, de Kraker, Marlieke E A et. al.
Binding properties of positively charged deoxynucleic guanidine (DNG), AgTgAgTgAgT and DNG/DNA chimeras to DNA
score: 1.033095, Bioorganic & Medicinal Chemistry Letters, 2008, Park, Myunji; Bruice, Thomas C.
Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.
score: 1.0330916, Antimicrobial agents and chemotherapy, 2000, Wang, Z X; Li, S M; Heide, L
The anticonvulsant activities of functionalized N-benzyl 2-acetamidoacetamides. The importance of the 2-acetamido substituent
score: 1.0330847, Bioorganic & Medicinal Chemistry, 1996, Choi, Daeock; Stables, James P; Kohn, Harold
parC mutation conferring ciprofloxacin resistance in Streptococcus pyogenes BM4513.
score: 1.0329048, Antimicrobial agents and chemotherapy, 2002, Alonso, Rodrigo; Galimand, Marc; Courvalin, Patrice
In vitro increase in chloroquine accumulation induced by dihydroethano- and ethenoanthracene derivatives in Plasmodium falciparum-parasitized erythrocytes.
score: 1.0329017, Antimicrobial agents and chemotherapy, 2002, Pradines, Bruno et. al.
Nucleoside analog 1592U89 and human immunodeficiency virus protease inhibitor 141W94 are synergistic in vitro.
score: 1.032892, Antimicrobial agents and chemotherapy, 1998, Drusano, G L et. al.
In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates.
score: 1.0328441, Antimicrobial agents and chemotherapy, 2010, Hagen, Ferry et. al.
Synthesis of pyridino[2,3- f]indole-4,9-dione 6,7-disubstituted quinoline-5,8-dione derivatives and evaluation on their cytotoxic activity
score: 1.0328426, Bioorganic & Medicinal Chemistry, 2001, Suh, Myung-Eun; Park, So-Young; Lee, Chong-Ock
l-Homoserylaminoethanol, a novel dipeptide alcohol inhibitor of eukaryotic DNA polymerase ε from a plant cultured cells, Nicotina tabacum L.
score: 1.0328225, Bioorganic & Medicinal Chemistry, 2004, Kuriyama, Isoko et. al.
Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis.
score: 1.0327714, Antimicrobial agents and chemotherapy, 2004, Mariam, Deneke H et. al.
QSPR modeling bioconcentration factor (BCF) by balance of correlations
score: 1.0327474, European Journal of Medicinal Chemistry, 2009, Toropov, A.A.; Toropova, A.P.; Benfenati, E.
Activation of NFκB is inhibited by curcumin and related enones
score: 1.0327386, Bioorganic & Medicinal Chemistry, 2006, Weber, Waylon M. et. al.
Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: Involvement of pyrrole formation on cell surface in antifungal action
score: 1.0326914, Bioorganic & Medicinal Chemistry, 2005, Fujita, Ken-ichi; Kubo, Isao
Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure
score: 1.0326669, European Journal of Medicinal Chemistry, 2002, Boussard, Cyrille et. al.
Mutations in gidB confer low-level streptomycin resistance in Mycobacterium tuberculosis.
score: 1.032623, Antimicrobial agents and chemotherapy, 2011, Wong, Sharon Y et. al.
Cure of Listeria monocytogenes meningitis after early transition to oral therapy.
score: 1.0326063, Antimicrobial agents and chemotherapy, 2010, Grant, Matthew H; Ravreby, Hannah; Lorber, Bennett
Synthesis and preliminary biological evaluation of the 99mTc labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers
score: 1.0325766, Bioorganic & Medicinal Chemistry Letters, 2006, Zhang, Yu et. al.
Pharmacokinetics and tolerability of oseltamivir combined with probenecid.
score: 1.0325462, Antimicrobial agents and chemotherapy, 2008, Holodniy, Mark et. al.
Multicenter survey of the changing in vitro antimicrobial susceptibilities of clinical isolates of Bacteroides fragilis group, Prevotella, Fusobacterium, Porphyromonas, and Peptostreptococcus species.
score: 1.0325245, Antimicrobial agents and chemotherapy, 2001, Aldridge, K E et. al.
Ciprofloxacin induction of a susceptibility determinant in Pseudomonas aeruginosa.
score: 1.0325066, Antimicrobial agents and chemotherapy, 2005, Brazas, Michelle D; Hancock, Robert E W
In vitro activities of newer quinolones against bacteroides group organisms.
score: 1.0325024, Antimicrobial agents and chemotherapy, 2002, Snydman, D R et. al.
Synthesis and Properties of Bile Acid Phosphoramidites 5′-Tethered to Antisense Oligodeoxynucleotides against HCV
score: 1.0324841, Bioorganic & Medicinal Chemistry, 2001, Lehmann, Thomas J.; Engels, Joachim W.
Structure–activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity
score: 1.0324727, Bioorganic & Medicinal Chemistry, 2006, Serradji, Nawal et. al.
Biochemical and molecular characterization of three new variants of AmpC beta-lactamases from Morganella morganii.
score: 1.0323051, Antimicrobial agents and chemotherapy, 2006, Power, Pablo et. al.
Versatile fluorescence labeling method using activated esters on solid support
score: 1.0322912, Bioorganic & Medicinal Chemistry Letters, 1999, Chang, Young-Tae; Schultz, Peter G.
Versatile fluorescence labeling method using activated esters on solid support
score: 1.0322912, Bioorganic & Medicinal Chemistry Letters, 1999, Chang, Young-Tae; Schultz, Peter G.
Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers.
score: 1.0322694, Antimicrobial agents and chemotherapy, 2006, Sansone-Parsons, Angela et. al.
Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.
score: 1.0321519, Antimicrobial agents and chemotherapy, 2012, Jiang, Zewei et. al.
In vitro and in vivo activities of CS-758 (R-120758), a new triazole antifungal agent.
score: 1.0321006, Antimicrobial agents and chemotherapy, 2002, Kamai, Yasuki et. al.
In vivo growth rates are poorly correlated with phage therapy success in a mouse infection model.
score: 1.0320929, Antimicrobial agents and chemotherapy, 2012, Bull, J J; Otto, G; Molineux, I J
In vitro pharmacodynamic characteristics of nystatin including time-kill and postantifungal effect.
score: 1.032042, Antimicrobial agents and chemotherapy, 2000, Gunderson, S M et. al.
Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area.
score: 1.0319602, Antimicrobial agents and chemotherapy, 1999, Wu, S W; Dornbusch, K; Kronvall, G
Evaluation of chelating agents as anti-angiogenic therapy through copper chelation
score: 1.031949, Bioorganic & Medicinal Chemistry, 2004, Camphausen, Kevin et. al.
Antimicrobial resistance of Neisseria gonorrhoeae and emerging ciprofloxacin resistance in the Netherlands, 1991 to 1998.
score: 1.0319263, Antimicrobial agents and chemotherapy, 2000, de Neeling, A J et. al.
Salmonella enterica serovar Typhimurium bla(PER-1)-carrying plasmid pSTI1 encodes an extended-spectrum aminoglycoside 6'-N-acetyltransferase of type Ib.
score: 1.0318994, Antimicrobial agents and chemotherapy, 2003, Casin, Isabelle et. al.
Molecular investigation of the postantibiotic effects of clarithromycin and erythromycin on Staphylococcus aureus cells.
score: 1.031797, Antimicrobial agents and chemotherapy, 1999, Champney, W S; Tober, C L
Effect of digestive site acidity and compatibility on the species, lipopily and bioavailability of iron, manganese and zinc in Prunus persica Batsch and Carthamus tinctorus
score: 1.0317585, Bioorganic & Medicinal Chemistry Letters, 2004, Shun-xing, Li; Nan-sheng, Deng; Feng-ying, Zheng
Genotypic and Phenotypic Evaluation of the Evolution of High-Level Daptomycin Nonsusceptibility in Vancomycin-Resistant Enterococcus faecium.
score: 1.0316495, Antimicrobial agents and chemotherapy, 2012, Humphries, Romney M et. al.
CTX-M-10 linked to a phage-related element is widely disseminated among Enterobacteriaceae in a Spanish hospital.
score: 1.0316358, Antimicrobial agents and chemotherapy, 2005, Oliver, Antonio et. al.
Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease P
score: 1.0315946, Bioorganic & Medicinal Chemistry Letters, 2004, Barnor, Jacob S. et. al.
Comparative in vitro activities of ABT-773 against aerobic and anaerobic pathogens isolated from skin and soft-tissue animal and human bite wound infections.
score: 1.0315932, Antimicrobial agents and chemotherapy, 2000, Goldstein, E J et. al.
Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
score: 1.0315824, European Journal of Medicinal Chemistry, 2006, Oliveira, A.M.A.G. et. al.
Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.
score: 1.0315317, Antimicrobial agents and chemotherapy, 2002, Bagge, Niels et. al.
Azithromycin versus ciprofloxacin for treatment of uncomplicated typhoid fever in a randomized trial in Egypt that included patients with multidrug resistance.
score: 1.0315304, Antimicrobial agents and chemotherapy, 1999, Girgis, N I et. al.
Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. Surveillance study.
score: 1.0314126, Antimicrobial agents and chemotherapy, 1999, Jacobs, M R et. al.
In vitro susceptibilities of four Bartonella bacilliformis strains to 30 antibiotic compounds.
score: 1.0314098, Antimicrobial agents and chemotherapy, 1999, Sobraquès, M; Maurin, M; Birtles, R J; Raoult, D
Fluconazole pharmacokinetics in burn patients.
score: 1.0313912, Antimicrobial agents and chemotherapy, 1998, Boucher, B A et. al.
A highly practical synthesis of the sialyl Lewis X pentasaccharide and an investigation of binding to E-, P-, and L-Selectins
score: 1.0313886, Bioorganic & Medicinal Chemistry, 1996, Kiyoi, Takao et. al.
Copper(II)/H 2O 2-mediated DNA cleavage: involvement of a copper(III) species in H-atom abstraction of deoxyribose units
score: 1.0313055, Bioorganic & Medicinal Chemistry Letters, 2002, Amine, Amina et. al.
Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules
score: 1.0312963, Bioorganic & Medicinal Chemistry Letters, 2010, Cheng, Shuk-Yan et. al.
Synthesis and biological evaluation of S-acyl-3-thiopropyl prodrugs of N-phosphonoacetyl- l-aspartate (PALA)
score: 1.0312825, European Journal of Medicinal Chemistry, 2003, Gagnard, Valérie et. al.
Identification and synthesis of new bicyclic acetals from the mountain pine beetle, Dendroctonus ponderosae hopkins (Col.: Scol.)
score: 1.0312483, Bioorganic & Medicinal Chemistry, 1996, Francke, W. et. al.
Complete Sequence of pJIE143, a pir-Type Plasmid Carrying ISEcp1-blaCTX-M-15 from an Escherichia coli ST131 Isolate.
score: 1.0312468, Antimicrobial agents and chemotherapy, 2011, Partridge, Sally R et. al.
A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus.
score: 1.0312161, Antimicrobial agents and chemotherapy, 2000, Katayama, Y; Ito, T; Hiramatsu, K
Synthesis of potent Ins(1,4,5)P 3 5-phosphatase inhibitors by modification of myo-inositol 1,3,4,6-tetrakisphosphate
score: 1.0312088, Bioorganic & Medicinal Chemistry, 2003, Mills, Stephen J; Potter, Barry V.L
Medium plays a role in determining expression of acrB, marA, and soxS in Escherichia coli.
score: 1.0311863, Antimicrobial agents and chemotherapy, 2006, Bailey, Andrew M; Webber, Mark A; Piddock, Laura J V
Resistance determinants and clonal diversity in group A streptococci collected during a period of increasing macrolide resistance.
score: 1.0311665, Antimicrobial agents and chemotherapy, 2002, Cresti, Stefania et. al.
In vitro activities of 13 fluoroquinolones against Staphylococcus aureus isolates with characterized mutations in gyrA, gyrB, grlA, and norA and against wild-type isolates.
score: 1.0311634, Antimicrobial agents and chemotherapy, 1999, Muñoz Bellido, J L et. al.
In vitro activities of oral beta-lactams at concentrations achieved in humans against penicillin-susceptible and -resistant pneumococci and potential to select resistance.
score: 1.031144, Antimicrobial agents and chemotherapy, 1998, Thorburn, C E; Knott, S J; Edwards, D I
Antimicrobial activity of a chelatable poly(arginyl-histidine) produced by the ergot fungus Verticillium kibiense.
score: 1.031127, Antimicrobial agents and chemotherapy, 2004, Nishikawa, Masanobu; Ogawa, Ken'ichi
Binding of an influenza A virus to a neomembrane measured by surface plasmon resonance
score: 1.0311132, Bioorganic & Medicinal Chemistry, 2004, Critchley, Peter; Dimmock, Nigel J.
Enantioselective synthesis and absolute configuration of (−)-1-(benzofuran-2-yl)-2-propylaminopentane, ((−)-BPAP), a highly potent and selective catecholaminergic activity enhancer
score: 1.0310976, Bioorganic & Medicinal Chemistry, 2001, Oka, Takahiro et. al.
Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia.
score: 1.0309912, Antimicrobial agents and chemotherapy, 2005, Clancy, Cornelius J et. al.
Structures, locations, and transfer frequencies of genetic elements conferring high-level gentamicin resistance in Enterococcus faecalis isolates in Greece.
score: 1.0309888, Antimicrobial agents and chemotherapy, 2003, Daikos, George L et. al.
Going gently into flight: analyzing noncovalent interactions by mass spectrometry
score: 1.0309541, Bioorganic & Medicinal Chemistry, 2003, Ganem, Bruce; Henion, Jack D
Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants.
score: 1.0309262, Antimicrobial agents and chemotherapy, 2011, Flynn, Patricia M et. al.
The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase.
score: 1.0308914, Antimicrobial agents and chemotherapy, 2011, Carvalho, Luis et. al.
Exploration of cornea permeable calpain inhibitors as anticataract agents
score: 1.0308547, Bioorganic & Medicinal Chemistry, 2003, Nakamura, Masayuki et. al.
A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp.
score: 1.0308147, Antimicrobial agents and chemotherapy, 1998, Tsai, S F et. al.
Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate
score: 1.0307796, Bioorganic & Medicinal Chemistry, 2012, Poreddy, Amruta R. et. al.
Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR.
score: 1.0307448, Antimicrobial agents and chemotherapy, 1998, Marr, K A et. al.
Isolation of Pseudomonas aeruginosa coproducing metallo-β-lactamase SPM-1 and 16S rRNA methylase RmtD1 in an urban river.
score: 1.0307384, Antimicrobial agents and chemotherapy, 2011, Fontes, Lívia C et. al.
gyrA Mutations associated with nalidixic acid-resistant salmonellae from wild birds.
score: 1.0307384, Antimicrobial agents and chemotherapy, 2002, Reche, M Paloma et. al.
Low correlation between MIC and mutant prevention concentration.
score: 1.0307215, Antimicrobial agents and chemotherapy, 2006, Drlica, Karl et. al.
The molecular structure of 2α-hydroxyneoanisatin and structure–activity relationships among convulsant sesquiterpenes of the seco-prezizaane and picrotoxane types
score: 1.0306938, Bioorganic & Medicinal Chemistry, 1999, Schmidt, Thomas J; Okuyama, Emi; Fronczek, Frank R
A solid-phase approach to DDB derivatives
score: 1.0306562, European Journal of Medicinal Chemistry, 2005, Qi, Xiuxiang et. al.
Recent advances in antitubercular natural products
score: 1.0306376, European Journal of Medicinal Chemistry, 2012, García, Abraham et. al.
Evaluation of a new line probe assay for rapid identification of gyrA mutations in Mycobacterium tuberculosis.
score: 1.0305979, Antimicrobial agents and chemotherapy, 2005, Giannoni, Federico et. al.
Genetic structures at the origin of acquisition and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-58 in Acinetobacter baumannii.
score: 1.0305889, Antimicrobial agents and chemotherapy, 2006, Poirel, Laurent; Nordmann, Patrice
Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice.
score: 1.0305504, Antimicrobial agents and chemotherapy, 2005, Pultz, Nicole J et. al.
Characterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens.
score: 1.0304914, Antimicrobial agents and chemotherapy, 2001, Decousser, J W; Poirel, L; Nordmann, P
Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations.
score: 1.0304616, Antimicrobial agents and chemotherapy, 2005, Garcia, Simone et. al.
Molecular cloning of the gyrA and gyrB genes of Bacteroides fragilis encoding DNA gyrase.
score: 1.0304069, Antimicrobial agents and chemotherapy, 1999, Onodera, Y; Sato, K
Novel fluorescent oligoDNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher
score: 1.0303568, Bioorganic & Medicinal Chemistry Letters, 2006, Kodama, Sinichi et. al.
An osteoclast-targeting agent for imaging and therapy of bone metastasis
score: 1.0303256, Bioorganic & Medicinal Chemistry Letters, 2008, Liu, Wei et. al.
Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.
score: 1.0303052, Antimicrobial agents and chemotherapy, 2001, Lurain, N S et. al.
Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains.
score: 1.0302896, Antimicrobial agents and chemotherapy, 2000, Heinemann, B; Wisplinghoff, H; Edmond, M; Seifert, H
First report of KPC-producing Pseudomonas aeruginosa in Brazil.
score: 1.0302634, Antimicrobial agents and chemotherapy, 2012, Jácome, Paula Regina Luna de Araújo et. al.
Synthesis of potential Rho-kinase inhibitors based on the chemistry of an original heterocycle: 4,4-Dimethyl-3,4-dihydro-1 H-quinolin-2-one
score: 1.0302535, European Journal of Medicinal Chemistry, 2008, Letellier, Marie-Anne et. al.
Detection of the KPC gene in Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii during a PCR-based nosocomial surveillance study in Puerto Rico.
score: 1.0302067, Antimicrobial agents and chemotherapy, 2011, Robledo, Iraida E; Aquino, Edna E; Vázquez, Guillermo J
Biochemical characterization of Sfh-I, a subclass B2 metallo-beta-lactamase from Serratia fonticola UTAD54.
score: 1.030196, Antimicrobial agents and chemotherapy, 2011, Fonseca, Fátima et. al.
The first metallo-beta-lactamase identified in norway is associated with a TniC-like transposon in a Pseudomonas aeruginosa isolate of sequence type 233 imported from Ghana.
score: 1.0301808, Antimicrobial agents and chemotherapy, 2009, Samuelsen, Orjan et. al.
Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates
score: 1.0301737, Bioorganic & Medicinal Chemistry, 2012, Gomaa, Mohamed S. et. al.
Frequency, Spectrum, and Nonzero Fitness Costs of Resistance to Myxopyronin in Staphylococcus aureus.
score: 1.0301653, Antimicrobial agents and chemotherapy, 2012, Srivastava, Aashish et. al.
Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance?
score: 1.0301556, Antimicrobial agents and chemotherapy, 2005, Coque, Teresa M et. al.
KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis.
score: 1.0301414, Antimicrobial agents and chemotherapy, 1998, Graybill, J R et. al.
Acyl-substituted dermaseptin S4 derivatives with improved bactericidal properties, including on oral microflora.
score: 1.0300723, Antimicrobial agents and chemotherapy, 2006, Porat, Y; Marynka, K; Tam, A; Steinberg, D; Mor, A
In vitro susceptibilities of gram-negative bacteria isolated from hospitalized patients in four European countries, Canada, and the United States in 2000-2001 to expanded-spectrum cephalosporins and comparator antimicrobials: implications for therapy.
score: 1.0300108, Antimicrobial agents and chemotherapy, 2003, Wenzel, Richard P et. al.
Increasing prevalence of methicillin-resistant Staphylococcus aureus causing nosocomial infections at a university hospital in Taiwan from 1986 to 2001.
score: 1.0299872, Antimicrobial agents and chemotherapy, 2004, Hsueh, Po-Ren et. al.
Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates
score: 1.0298866, Bioorganic & Medicinal Chemistry, 2005, Leśnikowski, Zbigniew J. et. al.
Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: implications for rapid susceptibility testing.
score: 1.0298669, Antimicrobial agents and chemotherapy, 2000, Piatek, A S et. al.
The antibiotic gentamicin inhibits specific protein trafficking functions of the Arf1/2 family of GTPases.
score: 1.0298317, Antimicrobial agents and chemotherapy, 2011, Lin, Lin et. al.
Cefepime versus imipenem-cilastatin for treatment of nosocomial pneumonia in intensive care unit patients: a multicenter, evaluator-blind, prospective, randomized study.
score: 1.0298121, Antimicrobial agents and chemotherapy, 2003, Zanetti, G et. al.
Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-{4-[3 R,5 S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl}-( R) ethanol
score: 1.0297699, Bioorganic & Medicinal Chemistry, 2003, Mylari, Banavara L. et. al.
Short-term measures of relative efficacy predict longer-term reductions in human immunodeficiency virus type 1 RNA levels following nelfinavir monotherapy.
score: 1.0296689, Antimicrobial agents and chemotherapy, 2001, Mittler, J et. al.
Postantibiotic effect of ceftobiprole against 12 Gram-positive organisms.
score: 1.0296043, Antimicrobial agents and chemotherapy, 2006, Pankuch, G A; Appelbaum, P C
Pronounced postantibiotic effect of quinupristin-dalfopristin in static cultures of Staphylococcus aureus: an effect not seen with other antibiotics.
score: 1.0296029, Antimicrobial agents and chemotherapy, 2000, Pfeil, E; Wiedemann, B
Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents
score: 1.0295304, Bioorganic & Medicinal Chemistry, 2000, Boger, Dale L. et. al.
The carboxyl terminus of peptidoglycan stem peptides is a determinant for methicillin resistance in Staphylococcus aureus.
score: 1.0294042, Antimicrobial agents and chemotherapy, 2002, De Jonge, Boudewijn L M; Gage, Douglas; Xu, Naxing
Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian hospitals reveals a limited diversity of gene cassette arrays.
score: 1.0293832, Antimicrobial agents and chemotherapy, 2002, Gombac, Francesca et. al.
Cerebrospinal fluid penetration and pharmacokinetics of vancomycin administered by continuous infusion to mechanically ventilated patients in an intensive care unit.
score: 1.0293754, Antimicrobial agents and chemotherapy, 2000, Albanèse, J et. al.
Rat liver microsomal enzyme catalyzed oxidation of 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine
score: 1.0293407, Bioorganic & Medicinal Chemistry, 1998, Zhao, Zhiyang et. al.
Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.
score: 1.0293332, Antimicrobial agents and chemotherapy, 2012, Murphey-Corb, Michael et. al.
16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium.
score: 1.0293026, Antimicrobial agents and chemotherapy, 1998, Ross, J I; Eady, E A; Cove, J H; Cunliffe, W J
Corrigendum to “Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca 2+-activated K + channel blockers” [Bioorg. Med. Chem. Lett. 19 18 (2008) 3440]
score: 1.0292659, Bioorganic & Medicinal Chemistry Letters, 2010, Graulich, Amaury et. al.
A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein
score: 1.0292346, Bioorganic & Medicinal Chemistry, 2005, Tolbert, Thomas J.; Franke, Dirk; Wong, Chi-Huey
Molecular structure and stereoelectronic properties of herbicide sulphonylureas
score: 1.0292, Bioorganic & Medicinal Chemistry, 2002, Galeazzi, R; Marucchini, C; Orena, M; Zadra, C
A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (−)-epigallocatechin gallate [(−)-EGCG]
score: 1.0291954, Bioorganic & Medicinal Chemistry, 2004, Lam, Wai Har et. al.
Comparative activities of clinafloxacin against gram-positive and -negative bacteria.
score: 1.0291945, Antimicrobial agents and chemotherapy, 1998, Ednie, L M; Jacobs, M R; Appelbaum, P C
Once-daily dosing in dogs optimizes daptomycin safety.
score: 1.0291181, Antimicrobial agents and chemotherapy, 2000, Oleson, F B et. al.
Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors
score: 1.0290916, European Journal of Medicinal Chemistry, 2012, Navarrete-Vazquez, Gabriel et. al.
Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors
score: 1.0290916, European Journal of Medicinal Chemistry, 2012, Navarrete-Vazquez, Gabriel et. al.
Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors
score: 1.0290916, European Journal of Medicinal Chemistry, 2012, Navarrete-Vazquez, Gabriel et. al.
Fluoroquinolone transport by human monocytes: characterization and comparison to other cells of myeloid lineage.
score: 1.0290486, Antimicrobial agents and chemotherapy, 2000, Bounds, S J; Nakkula, R; Walters, J D
Mathematical modeling of the interrelationship of CD4 lymphocyte count and viral load changes induced by the protease inhibitor indinavir.
score: 1.0290268, Antimicrobial agents and chemotherapy, 1998, Drusano, G L; Stein, D S
Postantibiotic effect and postantibiotic sub-MIC effect of quinupristin-dalfopristin against gram-positive and -negative organisms.
score: 1.0289861, Antimicrobial agents and chemotherapy, 1998, Pankuch, G A; Jacobs, M R; Appelbaum, P C
Emergence of PER-2 and VEB-1a in Acinetobacter baumannii Strains in the Americas.
score: 1.0289687, Antimicrobial agents and chemotherapy, 2006, Pasterán, Fernando et. al.
Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in Canada during 2000.
score: 1.0289475, Antimicrobial agents and chemotherapy, 2002, Low, Donald E et. al.
Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5.
score: 1.0289362, Antimicrobial agents and chemotherapy, 2006, Helmerhorst, Eva J et. al.
Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258.
score: 1.0289349, Antimicrobial agents and chemotherapy, 2009, Kitchel, Brandon et. al.
In vitro activities of new antifungal agents against Chaetomium spp. and inoculum standardization.
score: 1.028929, Antimicrobial agents and chemotherapy, 2003, Serena, Carolina et. al.
Vancomycin ototoxicity: a reevaluation in an era of increasing doses.
score: 1.0288933, Antimicrobial agents and chemotherapy, 2009, Forouzesh, Avisheh; Moise, Pamela A; Sakoulas, George
Use of a bioluminescent Pseudomonas aeruginosa strain within an in vitro microbiological system, as a model of wound infection, to assess the antimicrobial efficacy of wound dressings by monitoring light production.
score: 1.0288814, Antimicrobial agents and chemotherapy, 2007, Thorn, R M S; Nelson, S M; Greenman, J
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.
score: 1.0288638, Antimicrobial agents and chemotherapy, 2001, Sulavik, M C et. al.
A novel method for preparation of optically active α-monobenzoyl glycerol via lipase-catalyzed asymmetric transesterification of glycerol
score: 1.0288291, Bioorganic & Medicinal Chemistry Letters, 1999, Kato, Yasuo; Fujiwara, Isao; Asano, Yasuhisa
Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.
score: 1.0287767, Antimicrobial agents and chemotherapy, 2006, Hamelin, Marie-Eve; Prince, Gregory A; Boivin, Guy
Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages.
score: 1.0287675, Antimicrobial agents and chemotherapy, 2003, Seral, Cristina; Van Bambeke, Françoise; Tulkens, Paul M
Population pharmacokinetics of rifapentine and its primary desacetyl metabolite in South African tuberculosis patients.
score: 1.0287537, Antimicrobial agents and chemotherapy, 2005, Langdon, Grant et. al.
In vitro activities of polycationic peptides alone and in combination with clinically used antimicrobial agents against Rhodococcus equi.
score: 1.0287489, Antimicrobial agents and chemotherapy, 1999, Giacometti, A et. al.
Synthesis and in vitro antitumoral activity of new N-phenyl-3-pyrrolecarbothioamides
score: 1.02871, Bioorganic & Medicinal Chemistry, 2003, Cocco, Maria T.; Congiu, Cenzo; Onnis, Valentina
Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization.
score: 1.0286905, Antimicrobial agents and chemotherapy, 2008, Muthaiyan, Arunachalam et. al.
In vivo acquisition of ceftriaxone resistance in Salmonella enterica serotype anatum.
score: 1.028676, Antimicrobial agents and chemotherapy, 2003, Su, Lin-Hui et. al.
Telithromycin is active against Mycobacterium avium in mice despite lacking significant activity in standard in vitro and macrophage assays and is associated with low frequency of resistance during treatment.
score: 1.0286506, Antimicrobial agents and chemotherapy, 2001, Bermudez, L E et. al.
Mechanism of resistance to several antimicrobial agents in Salmonella Clinical isolates causing traveler's diarrhea.
score: 1.0286495, Antimicrobial agents and chemotherapy, 2004, Cabrera, Roberto et. al.
In vitro studies of pharmacodynamic properties of vancomycin against Staphylococcus aureus and Staphylococcus epidermidis.
score: 1.0284816, Antimicrobial agents and chemotherapy, 1998, Löwdin, E; Odenholt, I; Cars, O
Levofloxacin penetration into epithelial lining fluid as determined by population pharmacokinetic modeling and monte carlo simulation.
score: 1.0283798, Antimicrobial agents and chemotherapy, 2002, Drusano, G L et. al.
Mechanism of uptake of a cationic water-soluble pyridinium zinc phthalocyanine across the outer membrane of Escherichia coli.
score: 1.0283648, Antimicrobial agents and chemotherapy, 2000, Minnock, A et. al.
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.
score: 1.0283463, Antimicrobial agents and chemotherapy, 2005, Barr, S C et. al.
Derivation of an in vivo drug exposure breakpoint for flucytosine against Candida albicans and Impact of the MIC, growth rate, and resistance genotype on the antifungal effect.
score: 1.0283116, Antimicrobial agents and chemotherapy, 2006, Hope, William W et. al.
Characterization of a self-transferable plasmid from Salmonella enterica serotype typhimurium clinical isolates carrying two integron-borne gene cassettes together with virulence and drug resistance genes.
score: 1.0282776, Antimicrobial agents and chemotherapy, 2002, Guerra, Beatriz et. al.
Randomized trial of trimethoprim-sulfamethoxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS. Italian Collaborative Study Group.
score: 1.0282423, Antimicrobial agents and chemotherapy, 1998, Torre, D et. al.
Molecular analysis of rifampin resistance in Bacillus anthracis and Bacillus cereus.
score: 1.0282233, Antimicrobial agents and chemotherapy, 2002, Vogler, Amy J et. al.
Polyamine conjugates of meso-tritolylporphyrin and protoporphyrin IX: Potential agents for photodynamic therapy of cancers
score: 1.028192, Bioorganic & Medicinal Chemistry, 2006, Sol, Vincent et. al.
Synthesis and growth inhibition activity of α-Bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety
score: 1.0281906, Bioorganic & Medicinal Chemistry, 2003, Baraldi, Pier Giovanni et. al.
Effect of calcium carbonate on bioavailability of orally administered gemifloxacin.
score: 1.0281442, Antimicrobial agents and chemotherapy, 2003, Pletz, M W; Petzold, P; Allen, A; Burkhardt, O; Lode, H
Synthesis and biological activity of novel bifunctional isoxazolidinyl polycyclic aromatic hydrocarbons
score: 1.0281318, Bioorganic & Medicinal Chemistry, 2012, Rescifina, Antonio et. al.
Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus.
score: 1.0281187, Antimicrobial agents and chemotherapy, 2007, Milheiriço, Catarina et. al.
Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilization.
score: 1.028025, Antimicrobial agents and chemotherapy, 2011, Cuzon, Gaelle; Naas, Thierry; Nordmann, Patrice
In vitro antifungal susceptibilities of Sporothrix schenckii in two growth phases.
score: 1.0280107, Antimicrobial agents and chemotherapy, 2005, Trilles, Luciana et. al.
Determination of the in vivo pharmacodynamic profile of cefepime against extended-spectrum-beta-lactamase-producing Escherichia coli at various inocula.
score: 1.0279665, Antimicrobial agents and chemotherapy, 2004, Maglio, Dana et. al.
Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers.
score: 1.0279222, Antimicrobial agents and chemotherapy, 2004, Rigter, I M et. al.
Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase
score: 1.0279215, Bioorganic & Medicinal Chemistry, 2010, Jarmuła, Adam et. al.
A comparative molecular similarity indices (CoMSIA) study of peptide binding to the HLA-A3 superfamily
score: 1.0277193, Bioorganic & Medicinal Chemistry, 2003, Guan, Pingping; Doytchinova, Irini A; Flower, Darren R
Sodium lauryl sulfate increases the efficacy of a topical formulation of foscarnet against herpes simplex virus type 1 cutaneous lesions in mice.
score: 1.0276864, Antimicrobial agents and chemotherapy, 2000, Piret, J et. al.
Population pharmacokinetics of fluconazole in critically ill patients receiving continuous venovenous hemodiafiltration: using monte carlo simulations to predict doses for specified pharmacodynamic targets.
score: 1.0276666, Antimicrobial agents and chemotherapy, 2011, Patel, Kashyap et. al.
Safety, tolerability, and pharmacokinetics of single oral doses of BCH-10652 in healthy adult males.
score: 1.0275895, Antimicrobial agents and chemotherapy, 2000, Smith, P F; Forrest, A; Ballow, C H; Martin, D E; Proulx, L
In vitro postantibiotic effects of rifapentine, isoniazid, and moxifloxacin against Mycobacterium tuberculosis.
score: 1.0275754, Antimicrobial agents and chemotherapy, 2004, Chan, Chiu-Yeung et. al.
Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site † † This work was presented in part at the Association for Research in Vision and Ophthalmology annual meetings May 1999 and May 2000, Fort Lauderdale, FL, USA and at the Schepens Eye Research Institute's 50th Anniversary Symposium, October 2000. ‡ ‡ The nucleotide sequences reported in this paper have been submitted to the GenBank TM with accession numbers AF141347, AF141348, AF141349, AF141923, and AF147880.
score: 1.0275665, Bioorganic & Medicinal Chemistry, 2001, Crabtree, Donald V et. al.
The spiFEG Locus in Streptococcus infantarius subsp. infantarius BAA-102 Confers Protection against Nisin U.
score: 1.0275437, Antimicrobial agents and chemotherapy, 2012, Draper, Lorraine A et. al.
Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants
score: 1.0275209, Bioorganic & Medicinal Chemistry Letters, 1999, Kunnari, Tero et. al.
In vitro microbiological evaluation of 1,1'-(5,5'-(1,4-phenylene) bis (3-aryl-1 H -pyrazole-5,1-(4 H ,5 H )-diyl))diethanones, novel bis acetylated pyrazoles
score: 1.0275107, Organic and Medicinal Chemistry Letters, 2011, Kanagarajan, Vijayakumar et. al.
In vitro activities of azithromycin and ofloxacin against Chlamydia pneumoniae in a continuous-infection model.
score: 1.0274665, Antimicrobial agents and chemotherapy, 1999, Kutlin, A; Roblin, P M; Hammerschlag, M R
Geographic distribution of a large mobile element that transfers ampicillin and vancomycin resistance between Enterococcus faecium strains.
score: 1.0274363, Antimicrobial agents and chemotherapy, 2000, Hanrahan, J; Hoyen, C; Rice, L B
Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir.
score: 1.0273228, Antimicrobial agents and chemotherapy, 2012, Garcia-Rivera, Jose A et. al.
Antibiotic susceptibility patterns of Streptococcus pneumoniae in china and comparison of MICs by agar dilution and E-test methods.
score: 1.0272914, Antimicrobial agents and chemotherapy, 1998, Wang, H; Huebner, R; Chen, M; Klugman, K
Use of γ-aminopropyl-coated glass surface for the patterning of oligonucleotides through oxime bond formation
score: 1.0272435, Bioorganic & Medicinal Chemistry Letters, 2008, Dendane, Nabil et. al.
Comparative in vitro antimicrobial activities of the newly synthesized quinolone HSR-903, sitafloxacin (DU-6859a), gatifloxacin (AM-1155), and levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex.
score: 1.0272377, Antimicrobial agents and chemotherapy, 1999, Tomioka, H et. al.
Rifampin followed by ceftriaxone for experimental meningitis decreases lipoteichoic acid concentrations in cerebrospinal fluid and reduces neuronal damage in comparison to ceftriaxone alone.
score: 1.0272179, Antimicrobial agents and chemotherapy, 2003, Gerber, Joachim et. al.
Vancomycin resistance is maintained in enterococci in the viable but nonculturable state and after division is resumed.
score: 1.0272091, Antimicrobial agents and chemotherapy, 2003, Lleò, Maria Mar et. al.
Chemoproteomic approaches to drug target identification and drug profiling
score: 1.0271201, Bioorganic & Medicinal Chemistry, 2012, Bantscheff, Marcus; Drewes, Gerard
Photoreactive threading agent that specifically binds to abasic sites in DNA
score: 1.0270552, Bioorganic & Medicinal Chemistry Letters, 2006, Martelli, Alain et. al.
Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity
score: 1.0270156, European Journal of Medicinal Chemistry, 2004, You, Young-Jae et. al.
Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil.
score: 1.0270117, Antimicrobial agents and chemotherapy, 2002, Prazeres Magalhães, Paula et. al.
Iron-limited biofilms of Candida albicans and their susceptibility to amphotericin B.
score: 1.0269916, Antimicrobial agents and chemotherapy, 1998, Baillie, G S; Douglas, L J
Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide
score: 1.0269808, Bioorganic & Medicinal Chemistry Letters, 2004, Taguchi, Hiroaki et. al.
Comparison of three methods of determining MICs for filamentous fungi using different end point criteria and incubation periods.
score: 1.0269472, Antimicrobial agents and chemotherapy, 2000, Llop, C; Pujol, I; Aguilar, C; Sala, J; Riba, D; Guarro, J
Influence of renal failure on ciprofloxacin pharmacokinetics in rats.
score: 1.0269275, Antimicrobial agents and chemotherapy, 1998, Nouaille-Degorce, B et. al.
Density-functional theory and ab initio Hartree–Fork studies on the structural parameters and chemical activity of the free radicals generated by benzoquinone and hydroquinone
score: 1.0268311, Bioorganic & Medicinal Chemistry, 2005, Song, Yuanzhi et. al.
In vitro activities of voriconazole in combination with three other antifungal agents against Candida glabrata.
score: 1.0267722, Antimicrobial agents and chemotherapy, 2004, Barchiesi, Francesco et. al.
Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages.
score: 1.0267425, Antimicrobial agents and chemotherapy, 2011, Marsden, Matthew D et. al.
Carbapenem therapy for bacteremia due to extended-spectrum-β-lactamase-producing Escherichia coli or Klebsiella pneumoniae: implications of ertapenem susceptibility.
score: 1.0267374, Antimicrobial agents and chemotherapy, 2012, Lee, Nan-Yao et. al.
Effect of coadministration of vancomycin and BMP-2 on cocultured Staphylococcus aureus and W-20-17 mouse bone marrow stromal cells in vitro.
score: 1.026718, Antimicrobial agents and chemotherapy, 2012, Nguyen, A H; Kim, S; Maloney, W J; Wenke, J C; Yang, Y
Outcome of acute prosthetic joint infections due to gram-negative bacilli treated with open debridement and retention of the prosthesis.
score: 1.0267163, Antimicrobial agents and chemotherapy, 2009, Martínez-Pastor, Juan C et. al.
The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins
score: 1.0267057, Bioorganic & Medicinal Chemistry, 2000, Angus, Donald I; Kiefel, Milton J; Itzstein, Mark von
Dual Analyte Detection Using Tandem Flash Luminescence
score: 1.0266401, Bioorganic & Medicinal Chemistry Letters, 2002, Adamczyk, Maciej; Moore, Jeffrey A; Shreder, Kevin
Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release.
score: 1.0266133, Antimicrobial agents and chemotherapy, 2003, Coyle, Elizabeth A; Cha, Raymond; Rybak, Michael J
Correspondence of in vitro and in vivo fluconazole dose-response curves for Cryptococcus neoformans.
score: 1.0265926, Antimicrobial agents and chemotherapy, 2005, Larsen, Robert A et. al.
Pharmacokinetics-pharmacodynamics of cefepime and piperacillin-tazobactam against Escherichia coli and Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases: report from the ARREST program.
score: 1.0265327, Antimicrobial agents and chemotherapy, 2003, Ambrose, P G; Bhavnani, S M; Jones, R N
In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
score: 1.026497, Antimicrobial agents and chemotherapy, 2000, Brueggemann, A B et. al.
Standard numbering scheme for class B beta-lactamases.
score: 1.0264946, Antimicrobial agents and chemotherapy, 2001, Galleni, M et. al.
Efficacy of amphotericin B or itraconazole in a murine model of central nervous system Aspergillus infection.
score: 1.026486, Antimicrobial agents and chemotherapy, 2003, Chiller, Tom M et. al.
Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene.
score: 1.0264836, Antimicrobial agents and chemotherapy, 2004, Jensen, Susan E; Wong, Annie; Griffin, Alison; Barton, Barry
Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3′- C-ethynyluridine (EUrd) and 3′- C-ethynylcytidine (ECyd)
score: 1.0264761, Bioorganic & Medicinal Chemistry, 2005, Hrdlicka, Patrick J. et. al.
Pharmacokinetics of isepamicin during continuous venovenous hemodiafiltration.
score: 1.0264425, Antimicrobial agents and chemotherapy, 1999, Breilh, D et. al.
Synthesis and monoamine oxidase B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines
score: 1.0264188, Bioorganic & Medicinal Chemistry, 1999, Yu, Jian; Castagnoli Jr, Neal
Anti-DNA autoantibodies: the other DNA-binding proteins
score: 1.0262649, Bioorganic & Medicinal Chemistry, 1997, Bill, Roslyn M.; Blatt, Neal B.; Glick, Gary D.
Interlaboratory comparison of PCR-based methods for detection of penicillin G susceptibility in Neisseria meningitidis.
score: 1.0262379, Antimicrobial agents and chemotherapy, 2006, Taha, Muhamed-Kheir et. al.
A minimalist approach to fragment-based ligand design using common rings and linkers: application to kinase inhibitors.
score: 1.0262338, Proteins, 2004, Aronov, Alex M; Bemis, Guy W
Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.
score: 1.0261779, Antimicrobial agents and chemotherapy, 2009, Landersdorfer, Cornelia B et. al.
Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases
score: 1.0261534, Bioorganic & Medicinal Chemistry Letters, 2001, Nagaki, Masahiko et. al.
Successful trovafloxacin prophylaxis against experimental streptococcal aortic valve endocarditis.
score: 1.0260855, Antimicrobial agents and chemotherapy, 2000, Katsarolis, I et. al.
Detection of VIM-2 metallo-beta-lactamase in Pseudomonas aeruginosa from Germany.
score: 1.0260821, Antimicrobial agents and chemotherapy, 2005, Henrichfreise, Beate et. al.
Comparison of drug resistance scores for tipranavir in protease inhibitor-naive patients infected with HIV-1 B and non-B subtypes.
score: 1.0260734, Antimicrobial agents and chemotherapy, 2011, Stürmer, Martin et. al.
Chemoenzymatic synthesis of 1-deaza-pyridoxal 5′-phosphate
score: 1.0260364, Bioorganic & Medicinal Chemistry Letters, 2010, Griswold, Wait R.; Toney, Michael D.
A low background high-Throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone
score: 1.0259227, Bioorganic & Medicinal Chemistry Letters, 2003, Leroy, Emmanuel; Bensel, Nicolas; Reymond, Jean-Louis
Evidence of less severe aortic valve destruction after treatment of experimental staphylococcal endocarditis with vancomycin and dexamethasone.
score: 1.0259166, Antimicrobial agents and chemotherapy, 2001, Siaperas, P et. al.
Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases
score: 1.0259065, Bioorganic & Medicinal Chemistry, 2005, Saito, Akiko et. al.
Local genetic patterns within a vancomycin-resistant Enterococcus faecalis clone isolated in three hospitals in Portugal.
score: 1.0258457, Antimicrobial agents and chemotherapy, 2004, Novais, Carla et. al.
Photoinduced DNA cleavage by benzenediradical equivalents
score: 1.0257802, Bioorganic & Medicinal Chemistry Letters, 2003, Mohler, Debra L.; Gray Coonce, Janet; Predecki, Daniel
Inhibition of RNA synthesis as a therapeutic strategy against Aspergillus and Fusarium: demonstration of in vitro synergy between rifabutin and amphotericin B.
score: 1.025766, Antimicrobial agents and chemotherapy, 1998, Clancy, C J; Yu, Y C; Lewin, A; Nguyen, M H
Benzimidazole analogs inhibit human herpesvirus 6.
score: 1.0257555, Antimicrobial agents and chemotherapy, 2011, Prichard, Mark N et. al.
Evidence for transfer of CMY-2 AmpC beta-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans.
score: 1.0256925, Antimicrobial agents and chemotherapy, 2001, Winokur, P L et. al.
Cytotoxic trichilin-type limonoids from Melia azedarach
score: 1.0256887, Bioorganic & Medicinal Chemistry, 1996, Takeya, Koichi et. al.
Presence of the tet(O) gene in erythromycin- and tetracycline-resistant strains of Streptococcus pyogenes and linkage with either the mef(A) or the erm(A) gene.
score: 1.0256089, Antimicrobial agents and chemotherapy, 2003, Giovanetti, Eleonora et. al.
CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect
score: 1.0255824, Bioorganic & Medicinal Chemistry Letters, 2006, Anada, Takahisa et. al.
Molecular structure and stereoelectronic properties of sarmazenil—a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil
score: 1.0255494, Bioorganic & Medicinal Chemistry, 1998, López-Romero, B; Evrard, G; Durant, F; Sevrin, M; George, P
1- N-Substituted Thiocarbamoyl-3-Phenyl-2-Pyrazolines: Synthesis and In Vitro Antiamoebic Activities
score: 1.0255323, European Journal of Medicinal Chemistry, 2005, Abid, Mohammad; Azam, Amir
Antifungal activities of posaconazole and granulocyte-macrophage colony-stimulating factor ex vivo and in mice with disseminated infection due to Scedosporium prolificans.
score: 1.0254881, Antimicrobial agents and chemotherapy, 2004, Simitsopoulou, M et. al.
Efficacy of usual and high doses of daptomycin in combination with rifampin versus alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.
score: 1.0254265, Antimicrobial agents and chemotherapy, 2010, Garrigós, C et. al.
Proteomic approach to understanding antibiotic action.
score: 1.0254062, Antimicrobial agents and chemotherapy, 2003, Bandow, Julia Elisabeth et. al.
Enzymatic synthesis of aza- l-tyrosines
score: 1.0252187, Bioorganic & Medicinal Chemistry Letters, 2001, Watkins, E.Blake; Phillips, Robert S
Natural antibiotic susceptibilities of Edwardsiella tarda, E. ictaluri, and E. hoshinae.
score: 1.0251431, Antimicrobial agents and chemotherapy, 2001, Stock, I; Wiedemann, B
Detection of gyrA mutations among 335 Pseudomonas aeruginosa strains isolated in Japan and their susceptibilities to fluoroquinolones.
score: 1.0251162, Antimicrobial agents and chemotherapy, 1999, Takenouchi, T; Sakagawa, E; Sugawara, M
Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells.
score: 1.0251077, Antimicrobial agents and chemotherapy, 2002, Pascual, Alvaro et. al.
Very low cefotaxime concentrations select for hypermutable Streptococcus pneumoniae populations.
score: 1.0250723, Antimicrobial agents and chemotherapy, 2002, Negri, María-Cristina et. al.
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
score: 1.0250677, Antimicrobial agents and chemotherapy, 2003, Schneiders, T; Amyes, S G B; Levy, S B
Cefpodoxime-proxetil versus trimethoprim-sulfamethoxazole for short-term therapy of uncomplicated acute cystitis in women.
score: 1.0250559, Antimicrobial agents and chemotherapy, 2003, Kavatha, Demetra et. al.
Structure–Activity relationships among novel phenoxybenzamine-Related β-Chloroethylamines
score: 1.0250214, Bioorganic & Medicinal Chemistry, 2002, Giardinà, Dario et. al.
Identification of azole-responsive genes by microarray technology: why are we missing the efflux transporter genes?
score: 1.0249696, Antimicrobial agents and chemotherapy, 2001, Kontoyiannis, D P; May, G S
Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine
score: 1.0249607, European Journal of Medicinal Chemistry, 2002, Matosiuk, Dariusz et. al.
Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats.
score: 1.0249579, Antimicrobial agents and chemotherapy, 2002, Lozo, Edith et. al.
The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450
score: 1.0249075, Bioorganic & Medicinal Chemistry, 2012, Liu, Li et. al.
The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450
score: 1.0249075, Bioorganic & Medicinal Chemistry, 2012, Liu, Li et. al.
The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450
score: 1.0249075, Bioorganic & Medicinal Chemistry, 2012, Liu, Li et. al.
Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli.
score: 1.0248838, Antimicrobial agents and chemotherapy, 1999, Nelson, E C; Elisha, B G
1,4-Benzothiazine analogues and apoptosis
score: 1.0248799, Bioorganic & Medicinal Chemistry, 2003, Fringuelli, Renata et. al.
Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors.
score: 1.0248738, Antimicrobial agents and chemotherapy, 2011, Neuman, Benjamin W et. al.
A novel cholic acid-based contrast enhancement agent for targeted MRI
score: 1.0247367, Bioorganic & Medicinal Chemistry Letters, 2008, Chong, Hyun-Soon et. al.
Quinine pharmacokinetics and pharmacodynamics in children with malaria caused by Plasmodium falciparum.
score: 1.0247347, Antimicrobial agents and chemotherapy, 2005, Le Jouan, M et. al.
Molecular characterization and antimicrobial susceptibility of fluoroquinolone-resistant or -susceptible Streptococcus pneumoniae from Hong Kong.
score: 1.0247214, Antimicrobial agents and chemotherapy, 2003, Morrissey, Ian et. al.
Differential modulation of intracellular survival of cytosolic and vacuolar pathogens by curcumin.
score: 1.0247185, Antimicrobial agents and chemotherapy, 2012, Marathe, Sandhya A et. al.
pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia.
score: 1.0246957, Antimicrobial agents and chemotherapy, 1999, Marttila, H J et. al.
Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements.
score: 1.0246716, Antimicrobial agents and chemotherapy, 2009, International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC), et. al.
Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes.
score: 1.0244743, Antimicrobial agents and chemotherapy, 2004, Luque-Ortega, Juan Román et. al.
Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation
score: 1.0244179, Bioorganic & Medicinal Chemistry, 2012, Kashida, Hiromu et. al.
Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation
score: 1.0244179, Bioorganic & Medicinal Chemistry, 2012, Kashida, Hiromu et. al.
Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation
score: 1.0244179, Bioorganic & Medicinal Chemistry, 2012, Kashida, Hiromu et. al.
AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.
score: 1.0244041, Antimicrobial agents and chemotherapy, 2005, Ruzin, Alexey; Keeney, David; Bradford, Patricia A
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-Diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine
score: 1.0243759, Bioorganic & Medicinal Chemistry, 2003, Piergentili, Alessandro et. al.
Antibiotic resistance gene cluster of pAPEC-O1-R.
score: 1.0243535, Antimicrobial agents and chemotherapy, 2007, Hall, Ruth M
First synthesis of racemic saphenamycin and its enantiomers. investigation of biological activity
score: 1.0243515, Bioorganic & Medicinal Chemistry, 2003, Laursen, Jane B.; Jørgensen, Charlotte G.; Nielsen, John
Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants
score: 1.0243417, Bioorganic & Medicinal Chemistry, 2004, Schenck, Hilary A et. al.
Impact of the N348I mutation in HIV-1 reverse transcriptase on nonnucleoside reverse transcriptase inhibitor resistance in non-subtype B HIV-1.
score: 1.0243288, Antimicrobial agents and chemotherapy, 2011, McCormick, Adele L et. al.
Virological and pharmacological parameters predicting the response to lopinavir-ritonavir in heavily protease inhibitor-experienced patients.
score: 1.0243244, Antimicrobial agents and chemotherapy, 2005, Marcelin, Anne-Geneviève et. al.
2-Amino-Benzo[d]isothiazol-3-one derivatives: synthesis and assessment of their antiplatelet/spasmolytic effects
score: 1.0242785, Bioorganic & Medicinal Chemistry, 2000, Vicini, Paola et. al.
Affinity purification of von Willebrand factor using ligands derived from peptide libraries
score: 1.024271, Bioorganic & Medicinal Chemistry, 1996, Huang, Ping Y. et. al.
TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy.
score: 1.0242676, Antimicrobial agents and chemotherapy, 2000, Perilli, M et. al.
"tet(U)" is not a tetracycline resistance determinant.
score: 1.0242662, Antimicrobial agents and chemotherapy, 2012, Caryl, Jamie A et. al.
Evaluation of moxifloxacin, a new 8-methoxyquinolone, for treatment of meningitis caused by a penicillin-resistant pneumococcus in rabbits.
score: 1.0242642, Antimicrobial agents and chemotherapy, 1998, Ostergaard, C et. al.
Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophages.
score: 1.0242248, Antimicrobial agents and chemotherapy, 1998, van Etten, E W et. al.
Transmission electron microscopic study of antibiotic action on Klebsiella pneumoniae biofilm.
score: 1.0241975, Antimicrobial agents and chemotherapy, 2002, Zahller, Jeff; Stewart, Philip S
In vitro lectin-mediated selection and characterization of rHuEPO-α-binding ssDNA aptamers
score: 1.0241523, Bioorganic & Medicinal Chemistry, 2010, Zhang, Zhaoyang et. al.
Enhanced extracellular production of aspartyl proteinase, a virulence factor, by Candida albicans isolates following growth in subinhibitory concentrations of fluconazole.
score: 1.0241055, Antimicrobial agents and chemotherapy, 2000, Wu, T; Wright, K; Hurst, S F; Morrison, C J
Novel tetracycline resistance gene, tet(32), in the Clostridium-related human colonic anaerobe K10 and its transmission in vitro to the rumen anaerobe Butyrivibrio fibrisolvens.
score: 1.0240573, Antimicrobial agents and chemotherapy, 2001, Melville, C M; Scott, K P; Mercer, D K; Flint, H J
Interaction of binuclear xylylthiolato(2,2′,2″-terpyridine)platinum(II) complexes with DNA
score: 1.0240408, Bioorganic & Medicinal Chemistry Letters, 2003, Kurosaki, Hiromasa et. al.
Lack of effect of efavirenz on the pharmacokinetics of tipranavir-ritonavir in healthy volunteers.
score: 1.0240065, Antimicrobial agents and chemotherapy, 2009, la Porte, C J L; Sabo, J P; Béïque, L; Cameron, D W
Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals.
score: 1.0239686, Antimicrobial agents and chemotherapy, 2005, Riccio, Maria Letizia et. al.
Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States.
score: 1.0238873, Antimicrobial agents and chemotherapy, 2002, Karlowsky, James A et. al.
Human beta-defensin 2 induces a vigorous cytokine response in peripheral blood mononuclear cells.
score: 1.0238805, Antimicrobial agents and chemotherapy, 2006, Boniotto, Michele et. al.
Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis.
score: 1.0238374, Antimicrobial agents and chemotherapy, 2003, Collier, C T et. al.
Inactivation of the ampD gene in Pseudomonas aeruginosa leads to moderate-basal-level and hyperinducible AmpC beta-lactamase expression.
score: 1.0237988, Antimicrobial agents and chemotherapy, 2000, Langaee, T Y; Gagnon, L; Huletsky, A
Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis.
score: 1.0237397, Antimicrobial agents and chemotherapy, 2001, Silva, P E et. al.
In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides.
score: 1.0236306, Antimicrobial agents and chemotherapy, 2011, Jassem, Agatha N et. al.
Evaluation of disk diffusion method for determining eberconazole susceptibility of dermatophytes and influence of culture medium.
score: 1.0236127, Antimicrobial agents and chemotherapy, 2005, Fernández-Torres, Belkys; Inza, Isabel; Guarro, Josep
Attributable hospital cost and length of stay associated with health care-associated infections caused by antibiotic-resistant gram-negative bacteria.
score: 1.0235788, Antimicrobial agents and chemotherapy, 2010, Mauldin, Patrick D et. al.
Efflux pump-mediated quinolone resistance in Staphylococcus aureus strains wild type for gyrA, gyrB, grlA, and norA.
score: 1.0235315, Antimicrobial agents and chemotherapy, 1999, Muñoz-Bellido, J L et. al.
Antibacterial activities of the cathelicidins prophenin (residues 62 to 79) and LL-37 in the presence of a lung surfactant preparation.
score: 1.023522, Antimicrobial agents and chemotherapy, 2004, Wang, Yuqin et. al.
Three-dimensional quantitative structure–activity relationship (3D-QSAR) of 3-aryloxazolidin-2-one antibacterials
score: 1.0234552, Bioorganic & Medicinal Chemistry, 2001, Karki, Rajeshri G.; Kulkarni, Vithal M.
Synthesis of 2′-deoxyuridine 5′-(α,β-imido)triphosphate: a substrate analogue and potent inhibitor of dUTPase
score: 1.0234463, Bioorganic & Medicinal Chemistry, 1996, Persson, Tina; Larsson, Gunilla; Nyman, Per Olof
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges
score: 1.0234264, Bioorganic & Medicinal Chemistry, 1999, Gamble, William R. et. al.
Synthesis of probes with broad pH range fluorescence
score: 1.0233386, Bioorganic & Medicinal Chemistry Letters, 2003, Adamczyk, Maciej; Grote, Jonathan
Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids.
score: 1.0232457, Antimicrobial agents and chemotherapy, 2007, Novais, Angela et. al.
RmtD 16S RNA methylase in epidemiologically unrelated spm-1-producing Pseudomonas aeruginosa isolates from Brazil.
score: 1.0232457, Antimicrobial agents and chemotherapy, 2008, Castanheira, Mariana et. al.
Rollback of Salmonella enterica serotype Typhi resistance to chloramphenicol and other antimicrobials in Kolkata, India.
score: 1.0231571, Antimicrobial agents and chemotherapy, 2005, Dutta, Shanta et. al.
Effects of oleanolic acid glycosides on gastrointestinal transit and ileus in mice
score: 1.0231094, Bioorganic & Medicinal Chemistry, 1999, Li, Yuhao; Matsuda, Hisashi; Yoshikawa, Masayuki
Synthesis of Novel Polyphenols Consisted of Ferulic and Gallic Acids, and Their Inhibitory Effects on Phorbol Ester-Induced Epstein–Barr Virus Activation and Superoxide Generation
score: 1.0230768, Bioorganic & Medicinal Chemistry, 2002, Nomura, Eisaku et. al.
Controlling the intracellular localization of fluorescent polyamide analogues in cultured cells
score: 1.0230602, Bioorganic & Medicinal Chemistry Letters, 2003, Crowley, Kathleen S et. al.
Complete nucleotide sequence of KPC-3-encoding plasmid pKpQIL in the epidemic Klebsiella pneumoniae sequence type 258.
score: 1.0229346, Antimicrobial agents and chemotherapy, 2010, Leavitt, Azita et. al.
In vitro effects of ciprofloxacin and roxithromycin on apoptosis of jurkat T lymphocytes.
score: 1.0228852, Antimicrobial agents and chemotherapy, 2003, Jun, Yong-Taek et. al.
Patterns of macrolide resistance determinants among community-acquired Streptococcus pneumoniae isolates over a 5-year period of decreased macrolide susceptibility rates.
score: 1.0227988, Antimicrobial agents and chemotherapy, 1999, Oster, P et. al.
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
score: 1.0227944, Bioorganic & Medicinal Chemistry Letters, 2005, Tsukamoto, Sachiko et. al.
Comparison of two methods and three end points in determination of in vitro activity of micafungin against Aspergillus spp.
score: 1.022792, Antimicrobial agents and chemotherapy, 2003, Arikan, Sevtap; Yurdakul, Pinar; Hascelik, Gulsen
A model for evaluating topical antimicrobial efficacy against methicillin-resistant Staphylococcus aureus biofilms in superficial murine wounds.
score: 1.0227011, Antimicrobial agents and chemotherapy, 2012, Roche, Eric D et. al.
Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins.
score: 1.0226683, Antimicrobial agents and chemotherapy, 2002, Kuhn, D M et. al.
Carbapenem-resistant Klebsiella pnuemoniae in Singapore producing IMP-1 beta-lactamase and lacking an outer membrane protein.
score: 1.0226049, Antimicrobial agents and chemotherapy, 2001, Koh, T H et. al.
Prostate cancer PET bioprobes: Synthesis of [ 18F]-radiolabeled hydroxyflutamide derivatives
score: 1.022575, Bioorganic & Medicinal Chemistry, 2005, Jacobson, Orit et. al.
Characterization of the mupA gene in strains of methicillin-resistant Staphylococcus aureus with a low level of resistance to mupirocin.
score: 1.0225686, Antimicrobial agents and chemotherapy, 2001, Fujimura, S; Watanabe, A; Beighton, D
Development of a long acting human growth hormone analog suitable for once a week dosing
score: 1.0225591, Bioorganic & Medicinal Chemistry Letters, 2013, Palanki, Moorthy S.S. et. al.
Restoration of vancomycin susceptibility in Enterococcus faecalis by antiresistance determinant gene transfer.
score: 1.0225347, Antimicrobial agents and chemotherapy, 2001, Torres Viera, C et. al.
Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a pharmacokinetics/pharmacodynamics-based approach.
score: 1.0225165, Antimicrobial agents and chemotherapy, 2012, Pea, Federico et. al.
Effect of metronidazole on the pathogenicity of resistant Bacteroides strains in gnotobiotic mice.
score: 1.0224748, Antimicrobial agents and chemotherapy, 2000, Diniz, C G et. al.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
score: 1.0224555, Antimicrobial agents and chemotherapy, 2001, Yan, J J; Ko, W C; Wu, J J
Comparative activities of the triterpene saponin maesabalide III and liposomal amphotericin B (AmBisome) against Leishmania donovani in hamsters.
score: 1.0224317, Antimicrobial agents and chemotherapy, 2004, Maes, Louis et. al.
Biomimetic in vitro oxidation of lapachol: A model to predict and analyse the in vivo phase I metabolism of bioactive compounds
score: 1.0224175, European Journal of Medicinal Chemistry, 2012, Niehues, Michael et. al.
Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anticancer agents
score: 1.0223733, European Journal of Medicinal Chemistry, 2012, Yıldırım, Tuba et. al.
Evaluation of rifapentine in long-term treatment regimens for tuberculosis in mice.
score: 1.0222673, Antimicrobial agents and chemotherapy, 1999, Lenaerts, A M; Chase, S E; Chmielewski, A J; Cynamon, M H
Synthesis and biological evaluation of 1,8-naphthyridin-4(1 H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors
score: 1.0222622, Bioorganic & Medicinal Chemistry, 2004, Ferrarini, Pier Luigi et. al.
Novel anthracycline-spacer-β-glucuronide, -β-glucoside, and -β-galactoside prodrugs for application in selective chemotherapy
score: 1.0222523, Bioorganic & Medicinal Chemistry, 1999, Leenders, Ruben G.G. et. al.
Linezolid pharmacokinetics in adult patients with cystic fibrosis.
score: 1.0222197, Antimicrobial agents and chemotherapy, 2004, Bosso, John A; Flume, Patrick A; Gray, Susan L
Exposure to antibiotics induces expression of the Mycobacterium tuberculosis sigF gene: implications for chemotherapy against mycobacterial persistors.
score: 1.0222143, Antimicrobial agents and chemotherapy, 1999, Michele, T M; Ko, C; Bishai, W R
Telithromycin treatment of chronic Chlamydia pneumoniae infection in C57BL/6J mice.
score: 1.0221049, Antimicrobial agents and chemotherapy, 2004, Törmäkangas, Liisa et. al.
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation
score: 1.0220998, Bioorganic & Medicinal Chemistry, 2012, Sedláček, Ondřej et. al.
2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.
score: 1.0220959, Antimicrobial agents and chemotherapy, 2004, Bajramovic, Jeffrey J et. al.
Rapid, simple in vivo screen for new drugs active against Mycobacterium tuberculosis.
score: 1.0220914, Antimicrobial agents and chemotherapy, 2004, Nikonenko, Boris V et. al.
The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450
score: 1.022075, Bioorganic & Medicinal Chemistry, 2012, Liu, Li et. al.
Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.
score: 1.0219111, Antimicrobial agents and chemotherapy, 2010, Somé, Anyirékun Fabrice et. al.
In vitro activities of moxifloxacin and other fluoroquinolones against Mycoplasma pneumoniae.
score: 1.0218645, Antimicrobial agents and chemotherapy, 2001, Hamamoto, K; Shimizu, T; Fujimoto, N; Zhang, Y; Arai, S
Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.
score: 1.0217969, Antimicrobial agents and chemotherapy, 2004, Lee, Ann S G et. al.
Experimental and theoretical study on the supramolecular complexes of 15-crown-5 with adrenaline
score: 1.0216676, Bioorganic & Medicinal Chemistry Letters, 2010, Liu, Tao; Yu, Zhang-Yu
A novel anti-tumor agent, Ln(III) 2-thioacetate benzothiazole induces anti-angiogenic effect and cell death in cancer cell lines
score: 1.0216274, European Journal of Medicinal Chemistry, 2012, Hussein, Belal H.M. et. al.
A novel anti-tumor agent, Ln(III) 2-thioacetate benzothiazole induces anti-angiogenic effect and cell death in cancer cell lines
score: 1.0216274, European Journal of Medicinal Chemistry, 2012, Hussein, Belal H.M. et. al.
Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil.
score: 1.0216108, Antimicrobial agents and chemotherapy, 2005, Hayward, Rhys; Saliba, Kevin J; Kirk, Kiaran
Serum bactericidal activities of high-dose daptomycin with and without coadministration of gentamicin against isolates of Staphylococcus aureus and Enterococcus species.
score: 1.0216018, Antimicrobial agents and chemotherapy, 2006, DeRyke, C Andrew et. al.
In vitro activities of a new ketolide, ABT-773, alone and in combination with amoxicillin, metronidazole, or tetracycline against Helicobacter pylori.
score: 1.0215304, Antimicrobial agents and chemotherapy, 2000, Pendland, S L et. al.
In vitro interactions of approved and novel drugs against Paecilomyces spp.
score: 1.0215002, Antimicrobial agents and chemotherapy, 2004, Ortoneda, Montserrat et. al.
Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme from the marine sponge Hyrtios reticulatus
score: 1.0214203, Bioorganic & Medicinal Chemistry, 2012, Yamanokuchi, Rumi et. al.
Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi.
score: 1.0214047, Antimicrobial agents and chemotherapy, 1998, Troyer, J M; Radulovic, S; Andersson, S G; Azad, A F
Induction of {beta}-defensin resistance in the oral anaerobe Porphyromonas gingivalis.
score: 1.0213889, Antimicrobial agents and chemotherapy, 2005, Shelburne, Charles E et. al.
Fractal geometry and the pharmacometrics of micafungin in overweight, obese, and extremely obese people.
score: 1.0213048, Antimicrobial agents and chemotherapy, 2011, Hall, Ronald G; Swancutt, Mark A; Gumbo, Tawanda
Anion of hypericin is crucial to understanding the photosensitive features of the pigment
score: 1.0212952, Bioorganic & Medicinal Chemistry Letters, 2006, Shen, Liang; Ji, Hong-Fang; Zhang, Hong-Yu
Inhibition of cathepsin G by 4 H-3,1-benzoxazin-4-ones
score: 1.021253, Bioorganic & Medicinal Chemistry, 1997, Gütschow, Michael; Neumann, Ulf
Efficacy of daptomycin in implant-associated infection due to methicillin-resistant Staphylococcus aureus: importance of combination with rifampin.
score: 1.0211996, Antimicrobial agents and chemotherapy, 2009, John, Anne-Kathrin et. al.
Comparison of concentrations of sulbactam-ampicillin administered by bolus injections or bolus plus continuous infusion in tissues of patients undergoing colorectal surgery.
score: 1.0211973, Antimicrobial agents and chemotherapy, 1998, Martin, C et. al.
Antimicrobial susceptibility survey of Streptococcus pyogenes isolated in Japan from patients with severe invasive group A streptococcal infections.
score: 1.0211916, Antimicrobial agents and chemotherapy, 2005, Ikebe, Tadayoshi et. al.
Emergence of CTX-M-15-producing enterobacteria in Cameroon and characterization of a blaCTX-M-15-carrying element.
score: 1.0211814, Antimicrobial agents and chemotherapy, 2005, Gangoue-Pieboji, J et. al.
Nonoptimal DNA topoisomerases allow maintenance of supercoiling levels and improve fitness of Streptococcus pneumoniae.
score: 1.0211719, Antimicrobial agents and chemotherapy, 2011, Balsalobre, Luz et. al.
Biochemical characterization of TEM-92 extended-spectrum beta-lactamase, a protein differing from TEM-52 in the signal peptide.
score: 1.021151, Antimicrobial agents and chemotherapy, 2002, Perilli, Mariagrazia et. al.
Characterizing vancomycin-resistant Enterococcus strains with various mechanisms of daptomycin resistance developed in an in vitro pharmacokinetic/pharmacodynamic model.
score: 1.0210713, Antimicrobial agents and chemotherapy, 2011, Steed, Molly E et. al.
Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes.
score: 1.0210149, Antimicrobial agents and chemotherapy, 2011, Asahchop, Eugene L et. al.
Atomic force microscopy: application to investigation of Escherichia coli morphology before and after exposure to cefodizime.
score: 1.0209838, Antimicrobial agents and chemotherapy, 1998, Braga, P C; Ricci, D
Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1.
score: 1.0209595, Antimicrobial agents and chemotherapy, 1999, Kashuba, A D et. al.
In vitro activities of quinupristin-dalfopristin and the streptogramin RPR 106972 against Mycoplasma pneumoniae.
score: 1.0209513, Antimicrobial agents and chemotherapy, 1998, Izumikawa, K et. al.
Preparation of highly active α-chymotrypsin for catalysis in organic media
score: 1.0209373, Bioorganic & Medicinal Chemistry Letters, 2004, Roy, Ipsita; Gupta, Munishwar N
Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation.
score: 1.0209192, Bioorganic & Medicinal Chemistry, 1994, Williams, Peter D. et. al.
Synthesis and oxidant properties of novel (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl)ketonethiosemicarbazone
score: 1.020862, European Journal of Medicinal Chemistry, 2006, Karatas, Fikret; Koca, Murat; Kara, Haki; Servi, Süleyman
Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis
score: 1.020818, Bioorganic & Medicinal Chemistry, 1998, Sai, Yoshimichi et. al.
Synthesis and cellular studies of a carboranylchlorin for the PDT and BNCT of tumors
score: 1.0208044, Bioorganic & Medicinal Chemistry, 2006, Luguya, Raymond et. al.
Development and validation of limited-sampling strategies for predicting amoxicillin pharmacokinetic and pharmacodynamic parameters.
score: 1.0207409, Antimicrobial agents and chemotherapy, 2001, Suarez-Kurtz, G; Ribeiro, F M; Vicente, F L; Struchiner, C J
Human lactoferrin induces apoptosis-like cell death in Candida albicans: critical role of K+-channel-mediated K+ efflux.
score: 1.0207304, Antimicrobial agents and chemotherapy, 2008, Andrés, María T; Viejo-Díaz, Monica; Fierro, José F
Surveillance for antimicrobial susceptibility among clinical isolates of Pseudomonas aeruginosa and Acinetobacter baumannii from hospitalized patients in the United States, 1998 to 2001.
score: 1.0207016, Antimicrobial agents and chemotherapy, 2003, Karlowsky, James A et. al.
A practical molecular clip for immobilization of receptors and biomolecules on devices’ surface: Synthesis, grafting protocol and analytical assay
score: 1.0206756, Bioorganic & Medicinal Chemistry Letters, 2005, Devouge, Sabrina et. al.
Computer-Aided Simulation of a Dendrimer with a Protoporphyrinic Core as Potential, Novel Hemoprotein Mimic
score: 1.0206492, Bioorganic & Medicinal Chemistry, 2002, Fermeglia, Maurizio; Ferrone, Marco; Pricl, Sabrina
Concentrations of gatifloxacin in plasma and urine and penetration into prostatic and seminal fluid, ejaculate, and sperm cells after single oral administrations of 400 milligrams to volunteers.
score: 1.0206375, Antimicrobial agents and chemotherapy, 2001, Naber, C K et. al.
Feasibility of radioimmunotherapy of experimental pneumococcal infection.
score: 1.0206362, Antimicrobial agents and chemotherapy, 2004, Dadachova, E et. al.
In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates.
score: 1.0206048, Antimicrobial agents and chemotherapy, 2011, Pérez-Trallero, Emilio et. al.
N ω- propargyl- l-arginine and N ω- hydroxy-N ω- propargyl- l-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases
score: 1.0205683, Bioorganic & Medicinal Chemistry, 1997, Fast, Walter et. al.
N ω- propargyl- l-arginine and N ω- hydroxy-N ω- propargyl- l-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases
score: 1.0205683, Bioorganic & Medicinal Chemistry, 1997, Fast, Walter et. al.
A novel molecular modelling study of inhibitors of the 17α-hydroxylase component of the enzyme system 17α-hydroxylase/17,20-lyase (P-450 17α)
score: 1.0205621, Bioorganic & Medicinal Chemistry, 1999, Ahmed, Sabbir
Vibrio cholerae InV117, a class 1 integron harboring aac(6')-Ib and blaCTX-M-2, is linked to transposition genes.
score: 1.0205569, Antimicrobial agents and chemotherapy, 2006, Soler Bistué, Alfonso J C et. al.
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase
score: 1.0205155, European Journal of Medicinal Chemistry, 2001, Zuccotto, Fabio et. al.
Synthesis and activity on free radical processes and inflammation of 9,10-dihydro-5,8-dimethoxy-triptycene-quinones
score: 1.0204206, European Journal of Medicinal Chemistry, 2003, Xanthopoulou, Nikoletta J et. al.
Evaluation of a potential clinical interaction between ceftriaxone and calcium.
score: 1.0203623, Antimicrobial agents and chemotherapy, 2010, Steadman, Emily et. al.
Azetidin-2-one derivatives as inhibitors of thrombin
score: 1.0203143, Bioorganic & Medicinal Chemistry, 1995, Han, William T. et. al.
Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.
score: 1.0202672, Antimicrobial agents and chemotherapy, 2006, Zhao, Xilin et. al.
Kinetic properties of four plasmid-mediated AmpC beta-lactamases.
score: 1.0202385, Antimicrobial agents and chemotherapy, 2005, Bauvois, Cédric et. al.
Appropriateness of antimicrobial therapy measured by repeated prevalence surveys.
score: 1.020194, Antimicrobial agents and chemotherapy, 2007, Willemsen, Ina et. al.
Design, synthesis, stereochemistry and antioxidant properties of various 7-alkylated 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones
score: 1.0201685, Bioorganic & Medicinal Chemistry Letters, 2012, Park, Dong Ho et. al.
Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model.
score: 1.0201575, Antimicrobial agents and chemotherapy, 2000, Cynamon, M H; Carter, J L; Shoen, C M
Efficacy of calcium-EDTA as an inhibitor for metallo-β-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.
score: 1.0201418, Antimicrobial agents and chemotherapy, 2010, Aoki, Nobumasa et. al.
The host defense peptide LL-37 selectively permeabilizes apoptotic leukocytes.
score: 1.0198918, Antimicrobial agents and chemotherapy, 2009, Björstad, Ase et. al.
Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate.
score: 1.0198197, Antimicrobial agents and chemotherapy, 2008, El Fadili, Karima et. al.
Effects of halogen substitution on Watson–Crick base pairing: A possible mechanism for radiosensitivity
score: 1.0197602, Bioorganic & Medicinal Chemistry Letters, 2009, Heshmati, Emran et. al.
Antimicrobial susceptibilities and serogroups of clinical strains of Clostridium difficile isolated in France in 1991 and 1997.
score: 1.019721, Antimicrobial agents and chemotherapy, 1999, Barbut, F et. al.
Synergistic effects of anacardic acids and methicillin against methicillin resistant Staphylococcus aureus
score: 1.0197079, Bioorganic & Medicinal Chemistry, 2004, Muroi, Hisae; Nihei, Ken-ichi; Tsujimoto, Kazuo; Kubo, Isao
Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality.
score: 1.0196259, Antimicrobial agents and chemotherapy, 2001, LeClaire, R D; Bavari, S
Flow cytometry antifungal susceptibility testing of pathogenic yeasts other than Candida albicans and comparison with the NCCLS broth microdilution test.
score: 1.019603, Antimicrobial agents and chemotherapy, 2000, Ramani, R; Chaturvedi, V
Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults.
score: 1.0195977, Antimicrobial agents and chemotherapy, 2005, D'Ignazio, Joseph et. al.
Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist
score: 1.0195272, European Journal of Medicinal Chemistry, 2012, Bajare, Swapnil et. al.
Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist
score: 1.0195272, European Journal of Medicinal Chemistry, 2012, Bajare, Swapnil et. al.
Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase
score: 1.0194914, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L. et. al.
Increased mutation frequencies in Escherichia coli isolates harboring extended-spectrum beta-lactamases.
score: 1.0194819, Antimicrobial agents and chemotherapy, 2005, Baquero, María-Rosario et. al.
Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains.
score: 1.0194579, Antimicrobial agents and chemotherapy, 2005, Juan, Carlos et. al.
Magnetic resonance imaging of tumor cells by targeting the amino acid transport system
score: 1.0194273, Bioorganic & Medicinal Chemistry Letters, 2006, Lattuada, Luciano et. al.
Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives
score: 1.0193887, European Journal of Medicinal Chemistry, 2012, Quiroga, Ezequiel D. et. al.
Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives
score: 1.0193887, European Journal of Medicinal Chemistry, 2012, Quiroga, Ezequiel D. et. al.
Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives
score: 1.0193887, European Journal of Medicinal Chemistry, 2012, Quiroga, Ezequiel D. et. al.
Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters
score: 1.0193564, Bioorganic & Medicinal Chemistry, 2000, Yu, Han et. al.
Bronchopulmonary pharmacokinetics of clarithromycin and azithromycin.
score: 1.0192829, Antimicrobial agents and chemotherapy, 1998, Kashuba, A D; Amsden, G W
Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective.
score: 1.0192821, Antimicrobial agents and chemotherapy, 2002, Gillespie, Stephen H
Extrusion of penem antibiotics by multicomponent efflux systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa.
score: 1.0192459, Antimicrobial agents and chemotherapy, 2002, Okamoto, Kiyomi; Gotoh, Naomasa; Nishino, Takeshi
Sparfloxacin resistance in clinical isolates of Streptococcus pneumoniae: involvement of multiple mutations in gyrA and parC genes.
score: 1.0191685, Antimicrobial agents and chemotherapy, 1998, Taba, H; Kusano, N
Binding of Zn(II), Cu(II), and Fe(II) ions to alzheimer's Aß peptide studied by fluorescence
score: 1.0191306, Bioorganic & Medicinal Chemistry Letters, 1999, Garzon-Rodriguez, William et. al.
Synthesis and pharmacological evaluation of some N-arylsulfonyl- N-methyl- N′-(2,2-dimethyl-2 H-1-benzopyran-4-yl)ureas structurally related to cromakalim
score: 1.0191092, Bioorganic & Medicinal Chemistry, 2006, Khelili, Smail et. al.
Synergistic effect of CMP/KDO synthase inhibitors with antimicrobial agents on inhibition of production and release of vero toxin by enterohaemorrhagic Escherichia coli O157:H7
score: 1.0190978, Bioorganic & Medicinal Chemistry Letters, 2004, Kondo, Ken-ichiro et. al.
New antiproliferative benzoindolinothiazepines derivatives
score: 1.019075, European Journal of Medicinal Chemistry, 2005, Laconde, Guillaume et. al.
A pharmacokinetic study of amphotericin B lipid complex injection (Abelcet) in patients with definite or probable systemic fungal infections.
score: 1.0189414, Antimicrobial agents and chemotherapy, 2000, Adedoyin, A et. al.
In vitro activities of three licensed antifungal agents against spanish clinical isolates of Aspergillus spp.
score: 1.0188944, Antimicrobial agents and chemotherapy, 2003, Gomez-Lopez, Alicia et. al.
How pathogenic bacteria evade mammalian sabotage in the battle for iron.
score: 1.0188444, Nature chemical biology, 2006, Fischbach, Michael A et. al.
Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis.
score: 1.0188394, Antimicrobial agents and chemotherapy, 2000, Kawamura-Sato, K et. al.
Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols – Carbocyclic relatives of f-oxide-bridged phenylmorphans
score: 1.0186771, European Journal of Medicinal Chemistry, 2012, Li, Fuying et. al.
Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols – Carbocyclic relatives of f-oxide-bridged phenylmorphans
score: 1.0186771, European Journal of Medicinal Chemistry, 2012, Li, Fuying et. al.
Expanding the scope of site-specific protein biotinylation strategies using small molecules
score: 1.0186339, Bioorganic & Medicinal Chemistry Letters, 2004, Tan, Lay-Pheng; Chen, Grace Y.J.; Yao, Shao Q.
Effect of alkyl groups on the cellular hydrolysis of stavudine phosphoramidates
score: 1.0185887, Bioorganic & Medicinal Chemistry, 2006, Venkatachalam, T.K.; Sarquis, M.; Qazi, S.; Uckun, F.M.
Histatin 3-mediated killing of Candida albicans: effect of extracellular salt concentration on binding and internalization.
score: 1.0185136, Antimicrobial agents and chemotherapy, 1999, Xu, Y et. al.
Mutation in the Bacillus subtilis RNA polymerase beta' subunit confers resistance to lipiarmycin.
score: 1.0184494, Antimicrobial agents and chemotherapy, 2006, Gualtieri, Maxime et. al.
Identification of functional amino acids in the macrolide 2'-phosphotransferase II.
score: 1.0183334, Antimicrobial agents and chemotherapy, 1999, Taniguchi, K et. al.
Escherichia coli producing CTX-M-1, -2, and -9 group beta-lactamases in organic chicken egg production.
score: 1.0183214, Antimicrobial agents and chemotherapy, 2010, Bortolaia, Valeria et. al.
Intramacrophage passage of Mycobacterium tuberculosis and M. avium complex alters the drug susceptibilities of the organisms as determined by intracellular susceptibility testing using macrophages and type II alveolar epithelial cells.
score: 1.0183151, Antimicrobial agents and chemotherapy, 2002, Tomioka, Haruaki et. al.
Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats.
score: 1.0182943, Antimicrobial agents and chemotherapy, 1998, Stahlmann, R et. al.
Potential role of Veillonella spp. as a reservoir of transferable tetracycline resistance in the oral cavity.
score: 1.018205, Antimicrobial agents and chemotherapy, 2006, Ready, D et. al.
Clinical prediction of failure of Lamivudine prophylaxis for hepatitis B virus-infected patients undergoing cytotoxic chemotherapy for malignancy.
score: 1.0181774, Antimicrobial agents and chemotherapy, 2012, Kim, In Kyoung et. al.
Synthesis and enzymatic evaluation of pyridinium-Substituted uracil derivatives as novel inhibitors of thymidine phosphorylase
score: 1.0181595, Bioorganic & Medicinal Chemistry, 2002, Murray, Paul E et. al.
Molecular characterization of a ceftazidime-resistant Morganella morganii isolate producing a TEM-10 beta-lactamase.
score: 1.0180794, Antimicrobial agents and chemotherapy, 1999, Barroso, H; Freitas-Vieira, A; Duarte, A
Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure.
score: 1.0179756, Antimicrobial agents and chemotherapy, 1998, Kim, S H; Shim, H J; Kim, W B; Lee, M G
Synthesis, characterization of copper(II), cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of [7-hydroxy-4-methyl-8-coumarinyl]glycine and a comparitive study of their microbial activities
score: 1.0179191, European Journal of Medicinal Chemistry, 2008, Gudasi, Kalagouda B.; Patil, Manjula S.; Vadavi, Ramesh S.
Study on quantitative structure–toxicity relationships of benzene derivatives acting by narcosis
score: 1.0178598, Bioorganic & Medicinal Chemistry, 2002, Khadikar, Padmakar V. et. al.
MICs of oxazolidinones for Rhodococcus equi strains isolated from humans and animals.
score: 1.017803, Antimicrobial agents and chemotherapy, 2000, Bowersock, T L et. al.
Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).
score: 1.0177695, Antimicrobial agents and chemotherapy, 2004, Hirata, Takahiro et. al.
Structure–Activity relationships of 6-fluoroquinazolines: dual-Acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation
score: 1.0177603, Bioorganic & Medicinal Chemistry, 2003, Tobe, Masanori et. al.
Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin
score: 1.0177593, Bioorganic & Medicinal Chemistry, 2008, Zhou, Bin; Carney, Charlotte; Janda, Kim D.
The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease
score: 1.0176866, Bioorganic & Medicinal Chemistry, 1997, Rutenber, Earl E et. al.
Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive thai patients and healthy volunteers.
score: 1.0176824, Antimicrobial agents and chemotherapy, 2000, Wattanagoon, Y et. al.
Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
score: 1.0176499, Antimicrobial agents and chemotherapy, 2004, Vogne, Christelle et. al.
The T1R2/T1R3 Sweet Receptor and TRPM5 Ion Channel-Chapter 6:Taste Targets with Therapeutic Potential
score: 1.017478, Progress in Molecular Biology and Translational Science, 2010, Sprous, Dennis; Palmer, R. Kyle
Open-label, dose escalation study of the safety and pharmacokinetic profile of tefibazumab in healthy volunteers.
score: 1.0174422, Antimicrobial agents and chemotherapy, 2005, Reilley, Sandra et. al.
Ribavirin quantification in combination treatment of chronic hepatitis C.
score: 1.0174379, Antimicrobial agents and chemotherapy, 2003, Larrat, Sylvie et. al.
Antimicrobial susceptibility and composition of microcosm dental plaques supplemented with sucrose.
score: 1.0173407, Antimicrobial agents and chemotherapy, 1999, Pratten, J; Wilson, M
Syntheses and Biological Evaluation of Alkanediamines as Antioxidant and Hypolipidemic Agents
score: 1.0173084, Bioorganic & Medicinal Chemistry, 2001, Batra, Sanjay et. al.
Immunostimulatory activities of mono- or diglycosylated α-galactosylceramides
score: 1.0172649, Bioorganic & Medicinal Chemistry, 1997, Uchimura, Akira et. al.
Effects of Salmonella typhimurium infection and ofloxacin treatment on glucose and glutamine metabolism in Caco-2/TC-7 cells.
score: 1.0172123, Antimicrobial agents and chemotherapy, 1998, Posho, L et. al.
Genetic environments of the rmtA gene in Pseudomonas aeruginosa clinical isolates.
score: 1.0172105, Antimicrobial agents and chemotherapy, 2004, Yamane, Kunikazu et. al.
Efficacy of human simulated exposures of ceftaroline administered at 600 milligrams every 12 hours against phenotypically diverse Staphylococcus aureus isolates.
score: 1.0171178, Antimicrobial agents and chemotherapy, 2011, Keel, Rebecca A; Crandon, Jared L; Nicolau, David P
Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: data from community-based field clinics.
score: 1.0170325, Antimicrobial agents and chemotherapy, 2011, Rafiq, Yasraba et. al.
Evaluation of antibiotic susceptibilities of three rickettsial species including Rickettsia felis by a quantitative PCR DNA assay.
score: 1.0170059, Antimicrobial agents and chemotherapy, 2002, Rolain, Jean-Marc et. al.
Evolutionary changes in antimicrobial resistance of invasive Neisseria meningitidis isolates in Belgium from 2000 to 2010: increasing prevalence of penicillin nonsusceptibility.
score: 1.0169532, Antimicrobial agents and chemotherapy, 2012, Bertrand, Sophie et. al.
Relationship between the level of acquired resistance to gentamicin and synergism with amoxicillin in Enterococcus faecalis.
score: 1.0168954, Antimicrobial agents and chemotherapy, 2005, Aslangul, Elisabeth et. al.
Efficacy and tolerability of antibiotic combinations in neurobrucellosis: results of the Istanbul study.
score: 1.0168435, Antimicrobial agents and chemotherapy, 2012, Erdem, Hakan et. al.
Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases.
score: 1.0167712, Antimicrobial agents and chemotherapy, 2003, Paterson, David L et. al.
Detection and characterization of a macrolide 2'-phosphotransferase from a Pseudomonas aeruginosa clinical isolate.
score: 1.0167672, Antimicrobial agents and chemotherapy, 2000, Nakamura, A; Miyakozawa, I; Nakazawa, K; O-Hara, K; Sawai, T
Amikacin monotherapy for sepsis caused by panresistant Pseudomonas aeruginosa.
score: 1.0167597, Antimicrobial agents and chemotherapy, 2010, Layeux, Brice et. al.
Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice.
score: 1.0166299, Antimicrobial agents and chemotherapy, 2005, Spellberg, Brad; Fu, Yue; Edwards, John E; Ibrahim, Ashraf S
Tilmicosin induces apoptosis in bovine peripheral neutrophils in the presence or in the absence of Pasteurella haemolytica and promotes neutrophil phagocytosis by macrophages.
score: 1.0165991, Antimicrobial agents and chemotherapy, 2000, Chin, A C et. al.
Rapid ganciclovir susceptibility assay using flow cytometry for human cytomegalovirus clinical isolates.
score: 1.0165676, Antimicrobial agents and chemotherapy, 1998, McSharry, J J et. al.
In vivo fluconazole pharmacodynamics and resistance development in a previously susceptible Candida albicans population examined by microbiologic and transcriptional profiling.
score: 1.0165632, Antimicrobial agents and chemotherapy, 2006, Andes, D; Lepak, A; Nett, J; Lincoln, L; Marchillo, K
Linkage of vat(E) and erm(B) in streptogamin-resistant Enterococcus faecium isolates from Europe.
score: 1.0165365, Antimicrobial agents and chemotherapy, 2000, Jensen, L B; Hammerum, A M; Aarestrup, F M
Scaling adult doses of antifungal and antibacterial agents to children.
score: 1.0165321, Antimicrobial agents and chemotherapy, 2012, Dawson, Thomas H
Genotypic resistance in Helicobacter pylori strains correlates with susceptibility test and treatment outcomes after levofloxacin- and clarithromycin-based therapies.
score: 1.0165315, Antimicrobial agents and chemotherapy, 2011, Liou, Jyh-Ming et. al.
Telithromycin susceptibility and genomic diversity of macrolide-resistant serotype III group B streptococci isolated in perinatal infections.
score: 1.0164945, Antimicrobial agents and chemotherapy, 2004, Bingen, Edouard et. al.
Formation of multilamellar vesicles (‘onions’) in peptide based surfactant
score: 1.0164478, Bioorganic & Medicinal Chemistry Letters, 2000, Jayakumar, R; Murugesan, M; Ahmed, M.Rafiuddin
Fitness cost of chromosomal drug resistance-conferring mutations.
score: 1.0164146, Antimicrobial agents and chemotherapy, 2002, Sander, Peter et. al.
Single nucleotide specific detection of DNA by native chemical ligation of fluorescence labeled PNA-probes
score: 1.0164008, Bioorganic & Medicinal Chemistry, 2008, Dose, Christian; Seitz, Oliver
Synthetic chemistry: An upfront investment.
score: 1.0163751, Nature chemical biology, 2010, Young, Damian W
Synthesis and biological activity of novel substituted benzanilides as potassium channel activators. V
score: 1.0162784, European Journal of Medicinal Chemistry, 2004, Biagi, Giuliana et. al.
Variant Salmonella genomic island 1 antibiotic resistance gene cluster containing a novel 3'-N-aminoglycoside acetyltransferase gene cassette, aac(3)-Id, in Salmonella enterica serovar newport.
score: 1.0162449, Antimicrobial agents and chemotherapy, 2004, Doublet, Benoît et. al.
19F NMR Studies of Tryptophan/Serum Albumin Binding
score: 1.0162321, Bioorganic & Medicinal Chemistry, 2003, Cao, Bolong; Endsley, Stephanie; Andersen, Niels H
Affibody-displaying bionanocapsules for specific drug delivery to HER2-expressing cancer cells
score: 1.0161624, Bioorganic & Medicinal Chemistry Letters, 2010, Shishido, Takuya et. al.
Inhibition of nucleoside transport By new analogues of nitrobenzylthioinosine
score: 1.0161595, Bioorganic & Medicinal Chemistry, 2003, Deghati, Paymaneh Y.F et. al.
Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.
score: 1.0161348, Antimicrobial agents and chemotherapy, 2001, Wysocki, M et. al.
Breaking and entering.
score: 1.0161218, Nature chemical biology, 2006, Clackson, Tim
Analysis of the genetic variability of virulence-related loci in epidemic clones of methicillin-resistant Staphylococcus aureus.
score: 1.0161211, Antimicrobial agents and chemotherapy, 2005, Gomes, A R; Vinga, S; Zavolan, M; de Lencastre, H
Evaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaxime.
score: 1.0160473, Antimicrobial agents and chemotherapy, 2009, Lepercq, Jacques et. al.
Comparison of the effects of liposomal amphotericin B and conventional amphotericin B on propafenone metabolism and hepatic cytochrome P-450 in rats.
score: 1.0160096, Antimicrobial agents and chemotherapy, 2000, Inselmann, G; Volkmann, A; Heidemann, H T
Effect of continuous venovenous hemofiltration dose on achievement of adequate vancomycin trough concentrations.
score: 1.0159445, Antimicrobial agents and chemotherapy, 2012, Frazee, Erin N et. al.
Higher acyclic nitrogen containing deoxy sugar derivatives: A new lead in the generation of antimycobacterial chemotherapeutics
score: 1.0159324, Bioorganic & Medicinal Chemistry, 2002, Pathak, Rashmi et. al.
Microcin C51 plasmid genes: possible source of horizontal gene transfer.
score: 1.0159286, Antimicrobial agents and chemotherapy, 2003, Fomenko, Dmitri E et. al.
AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump.
score: 1.015834, Antimicrobial agents and chemotherapy, 2005, Wolter, Daniel J; Hanson, Nancy D; Lister, Philip D
In vitro efficacy of nikkomycin Z against the human isolate of the microsporidian species Encephalitozoon hellem.
score: 1.0158234, Antimicrobial agents and chemotherapy, 2000, Bigliardi, E et. al.
Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci.
score: 1.0157803, Antimicrobial agents and chemotherapy, 2002, Nagai, Kensuke et. al.
In vitro destruction of Streptococcus pneumoniae biofilms with bacterial and phage peptidoglycan hydrolases.
score: 1.0157646, Antimicrobial agents and chemotherapy, 2011, Domenech, Mirian; García, Ernesto; Moscoso, Miriam
Affinity labelling of the tick-borne encephalitis virus RNA replicase proteins by 4-n-exo-base-substituted photoreactive CTP analogs
score: 1.0157622, Bioorganic & Medicinal Chemistry Letters, 1998, Morozova, O.V. et. al.
Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor.
score: 1.0157269, Antimicrobial agents and chemotherapy, 2004, Vermitsky, John-Paul; Edlind, Thomas D
Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid.
score: 1.0157259, Antimicrobial agents and chemotherapy, 2002, Reinke, Ryan; Lee, Deborah J; Robinson, W Edward
First enzymatically activated Taxotere prodrugs designed for ADEPT and PMT
score: 1.0157021, Bioorganic & Medicinal Chemistry, 2004, Bouvier, Emmanuel et. al.
Induction of Apoptosis in HL-60 Cells by Photochemically Generated Hydroxyl Radicals
score: 1.0156644, Bioorganic & Medicinal Chemistry Letters, 2002, Haruna, Sakiko et. al.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
score: 1.0156119, Antimicrobial agents and chemotherapy, 2001, Chaves, J et. al.
(±)-3′- O, 4′- O-dicynnamoyl- cis-khellactone, a derivative of (±)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells
score: 1.0155931, Bioorganic & Medicinal Chemistry, 2006, Shen, Xiaoling et. al.
Molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli isolates causing bacteremia in the Calgary Health Region from 2000 to 2007: emergence of clone ST131 as a cause of community-acquired infections.
score: 1.015499, Antimicrobial agents and chemotherapy, 2009, Pitout, Johann D D et. al.
Improved synthesis of 2′-amino-2′-deoxyguanosine and its phosphoramidite
score: 1.0154849, Bioorganic & Medicinal Chemistry, 2006, Dai, Qing et. al.
Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii.
score: 1.015481, Antimicrobial agents and chemotherapy, 2000, Walker, D J et. al.
RNA aptamers that specifically bind to a K ras-derived farnesylated peptide
score: 1.0154635, Bioorganic & Medicinal Chemistry, 1997, Gilbert, Bryant A. et. al.
Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel
score: 1.015414, European Journal of Medicinal Chemistry, 2003, Battaglia, Arturo et. al.
Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin.
score: 1.0152145, Antimicrobial agents and chemotherapy, 1999, García-Arata, M I et. al.
Pharmacokinetics of amphotericin B colloidal dispersion in critically ill patients with cholestatic liver disease.
score: 1.0151817, Antimicrobial agents and chemotherapy, 2012, Weiler, Stefan et. al.
Semi-Synthesis of an O-Glycosylated docetaxel analogue
score: 1.0151128, Bioorganic & Medicinal Chemistry, 2003, Nikolakakis, Anastasia et. al.
Intravenous penciclovir for treatment of herpes simplex infections in immunocompromised patients: results of a multicenter, acyclovir-controlled trial. The Penciclovir Immunocompromised Study Group.
score: 1.0150895, Antimicrobial agents and chemotherapy, 1999, Lazarus, H M et. al.
Linezolid plus rifampin as a salvage therapy in prosthetic joint infections treated without removing the implant.
score: 1.0150779, Antimicrobial agents and chemotherapy, 2011, Gómez, J et. al.
Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa.
score: 1.0150774, Antimicrobial agents and chemotherapy, 2008, Wiegand, Irith et. al.
Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans.
score: 1.0150752, Antimicrobial agents and chemotherapy, 2010, Vediyappan, Govindsamy et. al.
Synthesis of modified proanthocyanidins: introduction of acyl substituents at C-8 of catechin. Selective synthesis of a C-4 → O → C-3 ether-linked procyanidin-like dimer
score: 1.014984, Bioorganic & Medicinal Chemistry Letters, 2005, Beauhaire, Josiane et. al.
High prevalence of carbapenem-resistant Acinetobacter baumannii carrying the blaOXA-143 gene in Brazilian hospitals.
score: 1.0149274, Antimicrobial agents and chemotherapy, 2011, Antonio, Charline S et. al.
Polyethylenimine effectively induces, stabilizes, and regulates intramolecular G-quadruplexes
score: 1.0149206, Bioorganic & Medicinal Chemistry Letters, 2009, Sun, Hongxia; Zhou, Qiuju; Xiang, Junfeng; Tang, Yalin
TD-1792 versus Vancomycin for Treatment of Complicated Skin and Skin Structure Infections.
score: 1.0148672, Antimicrobial agents and chemotherapy, 2012, Stryjewski, Martin E et. al.
Quinuclidinone O-Alkynyloximes with muscarinic agonist activity
score: 1.0148445, Bioorganic & Medicinal Chemistry, 2002, Somanadhan, Brinda et. al.
Prospective, multicenter surveillance study of Candida glabrata: fluconazole and itraconazole susceptibility profiles in bloodstream, invasive, and colonizing strains and differences between isolates from three urban teaching hospitals in New York City (Candida Susceptibility Trends Study, 1998 to 1999).
score: 1.0148261, Antimicrobial agents and chemotherapy, 2002, Safdar, Amar et. al.
Different pathways to acquiring resistance genes illustrated by the recent evolution of IncW plasmids.
score: 1.0147753, Antimicrobial agents and chemotherapy, 2008, Revilla, Carlos et. al.
A novel 11-residual peptaibol-derived carrier peptide for in vitro oligodeoxynucleotide delivery into cell
score: 1.0147697, Bioorganic & Medicinal Chemistry Letters, 2004, Wada, Shun-ich; Tanaka, Reiko
Role of P glycoprotein in absorption of novel antimalarial drugs.
score: 1.014631, Antimicrobial agents and chemotherapy, 2006, Crowe, Andrew et. al.
New description of protein–ligand interactions using a spherical self-organizing map
score: 1.0145999, Bioorganic & Medicinal Chemistry, 2012, Hasegawa, Kiyoshi; Funatsu, Kimito
New description of protein–ligand interactions using a spherical self-organizing map
score: 1.0145999, Bioorganic & Medicinal Chemistry, 2012, Hasegawa, Kiyoshi; Funatsu, Kimito
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes.
score: 1.0145115, Antimicrobial agents and chemotherapy, 1999, Hernández-Allés, S et. al.
Synergistic activity of the N-terminal peptide of human lactoferrin and fluconazole against Candida species.
score: 1.01443, Antimicrobial agents and chemotherapy, 2003, Lupetti, Antonella et. al.
Enhancement of amoxicillin resistance after unsuccessful Helicobacter pylori eradication.
score: 1.014407, Antimicrobial agents and chemotherapy, 2011, Nishizawa, Toshihiro et. al.
Immunomodulatory effects of fosfomycin in experimental human endotoxemia.
score: 1.0143826, Antimicrobial agents and chemotherapy, 2007, Sauermann, Robert et. al.
Pharmacokinetics of a new parenteral oligosaccharide antibiotic, SCH27899 (Ziracin), in healthy subjects.
score: 1.0143574, Antimicrobial agents and chemotherapy, 2001, Kozawa, O et. al.
Cytotoxic and genotoxic effects of [Ru(phi) 3] 2+ evaluated by Ames/ Salmonella and MTT methods
score: 1.0143471, European Journal of Medicinal Chemistry, 2009, Benkli, Kadriye et. al.
New non competitive AMPA antagonists
score: 1.0142456, Bioorganic & Medicinal Chemistry, 2000, Ábrahám, Gizella et. al.
Variation within the vat(E) allele of Enterococcus faecium isolates from retail poultry samples.
score: 1.0141898, Antimicrobial agents and chemotherapy, 2001, Simjee, S; McDermott, P F; Wagner, D D; White, D G
Synergistic in vitro antimalarial activity of omeprazole and quinine.
score: 1.014189, Antimicrobial agents and chemotherapy, 1999, Skinner-Adams, T; Davis, T M
Synthesis of dipeptide-bound epoxides and α,β-unsaturated amides as potential irreversible transglutaminase inhibitors
score: 1.0141826, Bioorganic & Medicinal Chemistry, 2002, de Macédo, Pierre; Marrano, Claudio; Keillor, Jeffrey W
Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan.
score: 1.0141791, Antimicrobial agents and chemotherapy, 2005, Ito, Masayasu et. al.
Inhibition of thermolysin and human α-thrombin by cobalt(III) Schiff base complexes
score: 1.0141357, Bioorganic & Medicinal Chemistry, 1999, Takeuchi, Toshihiko et. al.
Detection of methicillin-resistant Staphylococcus aureus strains resistant to multiple antibiotics and carrying the Panton-Valentine leukocidin genes in an Algiers hospital.
score: 1.0141194, Antimicrobial agents and chemotherapy, 2006, Ramdani-Bouguessa, Nadjia et. al.
Synthesis of novel DNA cross-linking antitumour agents based on polyazamacrocycles
score: 1.0140872, Bioorganic & Medicinal Chemistry, 2005, Parker, Laurie L. et. al.
Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance.
score: 1.0139806, Antimicrobial agents and chemotherapy, 2009, Furuse, Yuki; Suzuki, Akira; Oshitani, Hitoshi
Biotin-labeled abscisic acid as a probe for investigating abscisic acid binding sites on plasma membranes of barley aleurone protoplasts
score: 1.0139472, Bioorganic & Medicinal Chemistry, 2005, Kitahata, Nobutaka et. al.
Radiolabeled antibodies to Bacillus anthracis toxins are bactericidal and partially therapeutic in experimental murine anthrax.
score: 1.0139139, Antimicrobial agents and chemotherapy, 2009, Rivera, Johanna et. al.
Affinity of 5-thio- l-fucose-containing lewis X (Le X) trisaccharide analogs to anti-Le X monoclonal antibody
score: 1.0139133, Bioorganic & Medicinal Chemistry Letters, 1999, Tsuruta, Osamu et. al.
Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae.
score: 1.0138929, Antimicrobial agents and chemotherapy, 2002, Ng, Lai-King; Martin, Irene; Liu, Gary; Bryden, Louis
Rapid Identification of Carbapenemase Types in Enterobacteriaceae and Pseudomonas spp. by Using a Biochemical Test.
score: 1.0138734, Antimicrobial agents and chemotherapy, 2012, Dortet, Laurent; Poirel, Laurent; Nordmann, Patrice
Pharmacokinetic considerations and efficacy of levofloxacin in an inhalational anthrax (postexposure) rhesus monkey model.
score: 1.0138358, Antimicrobial agents and chemotherapy, 2006, Kao, L Mark et. al.
Highly regioselective synthesis of N-3 organophosphorous derivatives of 3,4-dihydropyrimidin-2(1H)-ones and their calcium channel binding studies
score: 1.0137214, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Highly regioselective synthesis of N-3 organophosphorous derivatives of 3,4-dihydropyrimidin-2(1H)-ones and their calcium channel binding studies
score: 1.0137214, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Highly regioselective synthesis of N-3 organophosphorous derivatives of 3,4-dihydropyrimidin-2(1H)-ones and their calcium channel binding studies
score: 1.0137214, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Differences between Macrolide-Resistant and -Susceptible Streptococcus pyogenes: Importance of Clonal Properties in Addition to Antibiotic Consumption.
score: 1.0137187, Antimicrobial agents and chemotherapy, 2012, Silva-Costa, C et. al.
Concentrations of tenofovir and emtricitabine in saliva: implications for preexposure prophylaxis of oral HIV acquisition.
score: 1.0137056, Antimicrobial agents and chemotherapy, 2011, de Lastours, Victoire et. al.
Maribavir antagonizes the antiviral action of ganciclovir on human cytomegalovirus.
score: 1.0136923, Antimicrobial agents and chemotherapy, 2006, Chou, Sunwen; Marousek, Gail I
Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus.
score: 1.0136103, Antimicrobial agents and chemotherapy, 2005, Xiong, Yan Q et. al.
Synthesis, chemical and enzymatic reactivity, and toxicity of dithymidylyl-3′,5′-phosphorofluoridate and -phosphorothiofluoridate
score: 1.0135999, Bioorganic & Medicinal Chemistry, 2001, Misiura, Konrad; Szymanowicz, Daria; Kuśnierczyk, Halina
Prevalence of macrolide resistance genes in clinical isolates of the Streptococcus anginosus ("S. milleri") group.
score: 1.0134962, Antimicrobial agents and chemotherapy, 2001, Jacobs, J A et. al.
Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis.
score: 1.0134897, Antimicrobial agents and chemotherapy, 2010, McClure, Jennifer C et. al.
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
score: 1.0134392, Antimicrobial agents and chemotherapy, 2000, Steffensky, M; Mühlenweg, A; Wang, Z X; Li, S M; Heide, L
Penetration of atazanavir in seminal plasma of men infected with human immunodeficiency virus type 1.
score: 1.0134298, Antimicrobial agents and chemotherapy, 2007, van Leeuwen, E et. al.
Reduced expression of the rplU-rpmA ribosomal protein operon in mexXY-expressing pan-aminoglycoside-resistant mutants of pseudomonas aeruginosa.
score: 1.0133629, Antimicrobial agents and chemotherapy, 2012, Lau, Calvin Ho-Fung et. al.
Photoaffinity analog of the semisynthetic echinocandin LY303366: identification of echinocandin targets in Candida albicans.
score: 1.013293, Antimicrobial agents and chemotherapy, 1998, Radding, J A; Heidler, S A; Turner, W W
Study of the interactions between tetracycline analogues and lysozyme
score: 1.0131826, Bioorganic & Medicinal Chemistry, 2004, Jiang, Chong-qiu; Wang, Ting
Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site
score: 1.013179, Bioorganic & Medicinal Chemistry, 2012, Abe, Yukiko et. al.
Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site
score: 1.013179, Bioorganic & Medicinal Chemistry, 2012, Abe, Yukiko et. al.
Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site
score: 1.013179, Bioorganic & Medicinal Chemistry, 2012, Abe, Yukiko et. al.
Methicillin-resistant Staphylococcus aureus screening by online immunometric monitoring of bacterial growth under selective pressure.
score: 1.0131312, Antimicrobial agents and chemotherapy, 2009, Stenholm, Teppo et. al.
Gatifloxacin and ethionamide as the foundation for therapy of tuberculosis.
score: 1.0130664, Antimicrobial agents and chemotherapy, 2003, Cynamon, Michael H; Sklaney, Mary
NagZ-dependent and NagZ-independent mechanisms for β-lactamase expression in Stenotrophomonas maltophilia.
score: 1.0130389, Antimicrobial agents and chemotherapy, 2012, Huang, Yi-Wei et. al.
Dosage-dependent antifungal efficacy of V-echinocandin (LY303366) against experimental fluconazole-resistant oropharyngeal and esophageal candidiasis.
score: 1.0130072, Antimicrobial agents and chemotherapy, 2001, Petraitis, V et. al.
Susceptibilities of Corynebacterium bovis and Corynebacterium amylocolatum isolates from bovine mammary glands to 15 antimicrobial agents.
score: 1.0129903, Antimicrobial agents and chemotherapy, 2000, Watts, J L; Rossbach, S
Alkylidene branched lupane derivatives: Synthesis and antitumor activity
score: 1.0129761, European Journal of Medicinal Chemistry, 2012, Csuk, René et. al.
Kinetics and structure–activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases
score: 1.0129182, Bioorganic & Medicinal Chemistry, 2004, Khalid, Asaad et. al.
Studies on the synthesis and properties of new PNA analogs consisting of L- and D-lysine backbones
score: 1.0128932, Bioorganic & Medicinal Chemistry Letters, 1999, Ligang Zhang, ; Jimei Min, ; Lihe Zhang,
Broad-spectrum β-lactam antibiotics for treating experimental peritonitis in mice due to Klebsiella pneumoniae producing the carbapenemase OXA-48.
score: 1.0128255, Antimicrobial agents and chemotherapy, 2012, Mimoz, Olivier et. al.
Antimicrobial susceptibility patterns among viridans group streptococcal isolates from infective endocarditis patients from 1971 to 1986 and 1994 to 2002.
score: 1.0128032, Antimicrobial agents and chemotherapy, 2004, Prabhu, Rajesh M et. al.
Differential expression of the Smb bacteriocin in Streptococcus mutans isolates.
score: 1.0127813, Antimicrobial agents and chemotherapy, 2008, Yonezawa, Hideo et. al.
Inhibition of voriconazole metabolism by chloramphenicol in an adolescent with central nervous system aspergillosis.
score: 1.0127133, Antimicrobial agents and chemotherapy, 2008, Hafner, Verena et. al.
Novel Ser79Leu and Ser81Ile substitutions in the quinolone resistance-determining regions of ParC topoisomerase IV and GyrA DNA gyrase subunits from recent fluoroquinolone-resistant Streptococcus pneumoniae clinical isolates.
score: 1.0126363, Antimicrobial agents and chemotherapy, 2005, Korzheva, Nataliya; Davies, Todd A; Goldschmidt, Raul
Recombinant anthrax toxin receptor-Fc fusion proteins produced in plants protect rabbits against inhalational anthrax.
score: 1.0126357, Antimicrobial agents and chemotherapy, 2011, Wycoff, Keith L et. al.
Antiproliferative properties of piperidinylchalcones
score: 1.0126245, Bioorganic & Medicinal Chemistry, 2006, Liu, Xiaoling; Go, Mei-Lin
Efficient synthesis of 8-Oxo-dGTP: A mutagenic nucleotide
score: 1.0125737, Bioorganic & Medicinal Chemistry Letters, 2000, Nampalli, Satyam; Kumar, Shiv
In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus spp.
score: 1.0125157, Antimicrobial agents and chemotherapy, 2002, Perea, Sofia et. al.
Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii.
score: 1.0125154, Antimicrobial agents and chemotherapy, 2010, Adams, Mark D et. al.
In vitro activities of gatifloxacin, two other quinolones, and five nonquinolone antimicrobials against obligately anaerobic bacteria.
score: 1.0124818, Antimicrobial agents and chemotherapy, 1999, Schaumann, R et. al.
Multidrug-resistant urinary tract isolates of Escherichia coli: prevalence and patient demographics in the United States in 2000.
score: 1.0124755, Antimicrobial agents and chemotherapy, 2001, Sahm, D F et. al.
Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency.
score: 1.0124701, Antimicrobial agents and chemotherapy, 2001, Wolf, D G; Yaniv, I; Ashkenazi, S; Honigman, A
Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker
score: 1.0124429, Bioorganic & Medicinal Chemistry, 2008, Ohkubo, Akihiro et. al.
Molecular evolution perspectives on intraspecific lateral DNA transfer of topoisomerase and gyrase loci in Streptococcus pneumoniae, with implications for fluoroquinolone resistance development and spread.
score: 1.0124322, Antimicrobial agents and chemotherapy, 2005, Stanhope, Michael J et. al.
Expression of OXA-type and SFO-1 β-lactamases induces changes in peptidoglycan composition and affects bacterial fitness.
score: 1.0124194, Antimicrobial agents and chemotherapy, 2012, Fernández, Ana et. al.
In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs.
score: 1.0124115, Antimicrobial agents and chemotherapy, 1999, Akova, M; Gür, D; Livermore, D M; Kocagöz, T; Akalin, H E
A ribozyme with michaelase activity
score: 1.0123464, Bioorganic & Medicinal Chemistry, 2003, Eisenführ, Alexander et. al.
Synthesis of benzamide derivatives of anacardic acid and their cytotoxic activity
score: 1.0123078, European Journal of Medicinal Chemistry, 2009, Chandregowda, Venkateshappa et. al.
Single-dose pharmacokinetics of indinavir and the effect of food.
score: 1.0122666, Antimicrobial agents and chemotherapy, 1998, Yeh, K C et. al.
Species differences in the proportion of plasma lipoprotein lipid carried by high-density lipoproteins influence the distribution of free and liposomal nystatin in human, dog, and rat plasma.
score: 1.0122115, Antimicrobial agents and chemotherapy, 1999, Ramaswamy, M; Wallace, T L; Cossum, P A; Wasan, K M
Adherence of Candida albicans to silicone induces immediate enhanced tolerance to fluconazole.
score: 1.0121849, Antimicrobial agents and chemotherapy, 2004, Mateus, Carolina; Crow, Sidney A; Ahearn, Donald G
Antifungal therapeutic drug monitoring: established and emerging indications.
score: 1.012136, Antimicrobial agents and chemotherapy, 2009, Andes, David; Pascual, Andres; Marchetti, Oscar
Fluoroquinolone-resistant Streptococcus agalactiae: epidemiology and mechanism of resistance.
score: 1.0121111, Antimicrobial agents and chemotherapy, 2005, Wehbeh, Wehbeh et. al.
Cytotoxic 2′,5′-dihydroxychalcones with unexpected antiangiogenic activity
score: 1.0120871, European Journal of Medicinal Chemistry, 2003, Nam, Nguyen-Hai et. al.
Molecular analysis of metallo-beta-lactamase gene bla(SPM-1)-surrounding sequences from disseminated Pseudomonas aeruginosa isolates in Recife, Brazil.
score: 1.0120585, Antimicrobial agents and chemotherapy, 2004, Poirel, Laurent et. al.
Improved automated synthesis of [ 18F]fluoroethylcholine as a radiotracer for cancer imaging
score: 1.0118754, Bioorganic & Medicinal Chemistry, 2007, Piel, M. et. al.
d(G 3T 4G 4) forms unusual dimeric G-quadruplex structure with the same general fold in the presence of K +, Na + or NH 4 + ions
score: 1.011809, Bioorganic & Medicinal Chemistry, 2004, Šket, Primož; Črnugelj, Martin; Plavec, Janez
Experimental and ‘in silico’ analysis of the effect of pH on HIV-1 protease inhibitor affinity: implications for the charge state of the protein ionogenic groups
score: 1.0117434, Bioorganic & Medicinal Chemistry, 2012, Domínguez, José L. et. al.
Preclinical characterization of JTK-853, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
score: 1.0117007, Antimicrobial agents and chemotherapy, 2012, Ando, Izuru et. al.
In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus.
score: 1.011659, Antimicrobial agents and chemotherapy, 2007, Deas, Tia S et. al.
Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects.
score: 1.0115975, Antimicrobial agents and chemotherapy, 2009, Ginsberg, Ann M et. al.
Synthesis, Antimicrobial and Antifungal Activity of a New Class of Spiro pyrrolidines
score: 1.0115812, Bioorganic & Medicinal Chemistry, 2003, Raj, A.Amal; Raghunathan, R; SrideviKumari, M.R; Raman, N
Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies
score: 1.011497, European Journal of Medicinal Chemistry, 2005, Tarasiuk, Jolanta et. al.
Synthesis and antimicrobial properties of 2-(benzylidene-amino)-benzo[ d]isothiazol-3-ones
score: 1.0114806, European Journal of Medicinal Chemistry, 2004, Zani, Franca; Vicini, Paola; Incerti, Matteo
Markedly enhancing lipase-catalyzed synthesis of nucleoside drugs’ ester by using a mixture system containing organic solvents and ionic liquid
score: 1.0114703, Bioorganic & Medicinal Chemistry Letters, 2006, Liu, Bo Kai; Wang, Na; Chen, Zhi Chun; Wu, Qi; Lin, Xian Fu
Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di- N-oxide
score: 1.0113722, Bioorganic & Medicinal Chemistry, 2001, Ganley, Brian et. al.
Microcin E492 is an unmodified peptide related in structure to colicin V.
score: 1.0113306, Antimicrobial agents and chemotherapy, 2002, Pons, Anne-Marie et. al.
Effects of alpha-thalassemia on pharmacokinetics of the antimalarial agent artesunate.
score: 1.0113222, Antimicrobial agents and chemotherapy, 1998, Ittarat, W et. al.
Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration of colistin methanesulfonate.
score: 1.0112843, Antimicrobial agents and chemotherapy, 2012, Imberti, Roberto et. al.
Protein phosphatase 2A inhibition and circumvention of cisplatin cross-resistance by novel TCM-platinum anticancer agents containing demethylcantharidin
score: 1.0112537, Bioorganic & Medicinal Chemistry, 2004, To, Kenneth K.W. et. al.
Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.
score: 1.0111898, Antimicrobial agents and chemotherapy, 2007, Humphreys, G S et. al.
Microflora changes with norfloxacin and pivmecillinam in women with recurrent urinary tract infection.
score: 1.0111397, Antimicrobial agents and chemotherapy, 2006, Norinder, Birgit Stattin et. al.
Plasma amprenavir pharmacokinetics and tolerability following administration of 1,400 milligrams of fosamprenavir once daily in combination with either 100 or 200 milligrams of ritonavir in healthy volunteers.
score: 1.0111381, Antimicrobial agents and chemotherapy, 2007, Ruane, Peter J et. al.
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies
score: 1.0111272, Bioorganic & Medicinal Chemistry, 2006, Farid, Ramy et. al.
Low frequency of intermittent HIV-1 semen excretion in patients treated with darunavir-ritonavir at 600/100 milligrams twice a day plus two nucleoside reverse transcriptase inhibitors or monotherapy.
score: 1.0110688, Antimicrobial agents and chemotherapy, 2010, Lambert-Niclot, Sidonie et. al.
A one-step synthesis of a deuterated paclitaxel analogue: 10-Deacetoxy-(10α- 2H)paclitaxel
score: 1.0110307, Bioorganic & Medicinal Chemistry Letters, 1999, Dutta, Dinah et. al.
In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp.
score: 1.0109959, Antimicrobial agents and chemotherapy, 1999, Kenny, D J; Russell, P; Rogers, D; Eley, S M; Titball, R W
Cyclic and linear oligocarbamate ligands for human thrombin
score: 1.0109869, Bioorganic & Medicinal Chemistry, 1999, Cho, Charles Y. et. al.
Bloodstream infections with metallo-beta-lactamase-producing Pseudomonas aeruginosa: epidemiology, microbiology, and clinical outcomes.
score: 1.010976, Antimicrobial agents and chemotherapy, 2006, Marra, Alexandre R et. al.
Susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada.
score: 1.0109702, Antimicrobial agents and chemotherapy, 2011, Patel, Samir N et. al.
An efficient enzymatic synthesis of thiamin pyrophosphate
score: 1.0109392, Bioorganic & Medicinal Chemistry Letters, 2003, Melnick, Jonathan S et. al.
Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells
score: 1.0108691, Bioorganic & Medicinal Chemistry Letters, 1999, Shen, Zhong-Jian et. al.
Inhibition of Thioredoxin Reductase by a Novel Series of Bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium Compounds for Cancer Therapy
score: 1.0108554, Bioorganic & Medicinal Chemistry, 2012, He, Jie et. al.
Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26.
score: 1.0108487, Antimicrobial agents and chemotherapy, 1999, Horii, T; Kimura, T; Sato, K; Shibayama, K; Ohta, M
Improved pharmacokinetics and reduced antibody reactivity of lysostaphin conjugated to polyethylene glycol.
score: 1.0108457, Antimicrobial agents and chemotherapy, 2003, Walsh, Scott; Shah, Anjali; Mond, James
Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes.
score: 1.0108428, Antimicrobial agents and chemotherapy, 2004, Go, Mei-Lin et. al.
New aspects of formation of 1,2-cyclic phosphates by phospholipase C-δ1
score: 1.0107361, Bioorganic & Medicinal Chemistry, 2003, Liu, Yinghui et. al.
The nucleation of monomeric parallel β-sheet-like structures and their self-assembly in aqueous solution
score: 1.0107293, Bioorganic & Medicinal Chemistry, 1999, Chitnumsub, Penchit et. al.
Pharmacokinetics of fosamprenavir plus ritonavir in human immunodeficiency virus type 1-infected adult subjects with hepatic impairment.
score: 1.0107096, Antimicrobial agents and chemotherapy, 2009, Pérez-Elías, María J et. al.
Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects
score: 1.0106222, Bioorganic & Medicinal Chemistry Letters, 2007, Tsujimoto, Hiroyuki et. al.
Antimicrobial susceptibility of Haemophilus influenzae in the respiratory tracts of patients with cystic fibrosis.
score: 1.0105125, Antimicrobial agents and chemotherapy, 1998, Möller, L V et. al.
The combination of meropenem and levofloxacin is synergistic with respect to both Pseudomonas aeruginosa kill rate and resistance suppression.
score: 1.010486, Antimicrobial agents and chemotherapy, 2010, Louie, Arnold et. al.
Influence of liposomal amphotericin B on CD8 T-cell function.
score: 1.0104543, Antimicrobial agents and chemotherapy, 2001, Kretschmar, M et. al.
Introduction of a norA promoter region mutation into the chromosome of a fluoroquinolone-susceptible strain of Staphylococcus aureus using plasmid integration.
score: 1.0103715, Antimicrobial agents and chemotherapy, 1999, Kaatz, G W; Seo, S M; Foster, T J
Purification, reconstitution, and inhibition of cytochrome P-450 sterol delta22-desaturase from the pathogenic fungus Candida glabrata.
score: 1.0103636, Antimicrobial agents and chemotherapy, 1999, Lamb, D C et. al.
High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria.
score: 1.0102817, Antimicrobial agents and chemotherapy, 2009, Sabtcheva, Stefana et. al.
Herb-drug interaction between Echinacea purpurea and etravirine in HIV-infected patients.
score: 1.0102728, Antimicrobial agents and chemotherapy, 2012, Moltó, José et. al.
Unique O-ribosylation in the biosynthesis of butirosin
score: 1.0102338, Bioorganic & Medicinal Chemistry, 2007, Kudo, Fumitaka et. al.
Inhibition of secretory phospholipase A 2. 1-Design, synthesis and structure–activity relationship studies starting from 4-tetradecyloxybenzamidine to obtain specific inhibitors of group II sPLA 2s
score: 1.0101965, European Journal of Medicinal Chemistry, 2005, Assogba, Léon et. al.
Comparative susceptibilities to fidaxomicin (OPT-80) of isolates collected at baseline, recurrence, and failure from patients in two phase III trials of fidaxomicin against Clostridium difficile infection.
score: 1.010186, Antimicrobial agents and chemotherapy, 2011, Goldstein, Ellie J C et. al.
Selection and syntheses of tentacle type peptides as ‘artificial’ lectins against various cell-surface carbohydrates
score: 1.0101504, Bioorganic & Medicinal Chemistry, 2007, Hyun, Soonsil; Kim, Jiyoung; Kwon, Miyun; Yu, Jaehoon
Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.
score: 1.0101452, Antimicrobial agents and chemotherapy, 2011, Green, Keith D; Chen, Wenjing; Garneau-Tsodikova, Sylvie
Secondary assembly of bile salts mediated by β-cyclodextrin–terbium(III) complex
score: 1.0101269, Bioorganic & Medicinal Chemistry, 2006, Liu, Yu; Zhang, Ning; Chen, Yong; Chen, Guo-Song
G-quadruplex structures of human telomere DNA examined by single molecule FRET and BrG-substitution
score: 1.0100263, Bioorganic & Medicinal Chemistry, 2008, Okamoto, Kenji et. al.
Carbapenem resistance in Elizabethkingia meningoseptica is mediated by metallo-β-lactamase BlaB.
score: 1.0099564, Antimicrobial agents and chemotherapy, 2012, González, Lisandro J; Vila, Alejandro J
Fullerene derivatives: an attractive tool for biological applications
score: 1.0097481, European Journal of Medicinal Chemistry, 2003, Bosi, Susanna et. al.
Increasing chloramphenicol resistance in Streptococcus pneumoniae isolates from Papua New Guinean children with acute bacterial meningitis.
score: 1.0097373, Antimicrobial agents and chemotherapy, 2011, Manning, Laurens et. al.
First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.
score: 1.0097004, Antimicrobial agents and chemotherapy, 2004, Gieffers, Jens et. al.
A novel thermophilic Glycosynthase that effects branching glycosylation
score: 1.009677, Bioorganic & Medicinal Chemistry Letters, 2000, Trincone, A.; Perugino, G.; Rossi, M.; Moracci, M.
Real-time PCR for dihydrofolate reductase gene single-nucleotide polymorphisms in Plasmodium vivax isolates.
score: 1.0096451, Antimicrobial agents and chemotherapy, 2004, Brega, Sara et. al.
DNA binding and antimicrobial studies of polymer–copper(II) complexes containing 1,10-phenanthroline and l-phenylalanine ligands
score: 1.0096397, European Journal of Medicinal Chemistry, 2009, Kumar, Rajendran Senthil; Arunachalam, Sankaralingam
Pharmacokinetics and safety of caspofungin in neonates and infants less than 3 months of age.
score: 1.0095959, Antimicrobial agents and chemotherapy, 2009, Sáez-Llorens, Xavier et. al.
QSAR of apoptosis induction in various cancer cells
score: 1.009576, Bioorganic & Medicinal Chemistry, 2003, Hansch, Corwin et. al.
Diversity of structures carrying the high-level gentamicin resistance gene (aac6-aph2) in Enterococcus faecalis strains isolated in France.
score: 1.0095604, Antimicrobial agents and chemotherapy, 1998, Casetta, A; Hoï, A B; de Cespédès, G; Horaud, T
Optimization of isotope-labeling conditions for lambertellin based on isotope patterns observed by mass spectrometry
score: 1.009284, Bioorganic & Medicinal Chemistry Letters, 2005, Murakami, Takanori et. al.
Reprint of BMCL_19101
score: 1.0092302, Bioorganic & Medicinal Chemistry Letters, 2012, Lansdell, Theresa A. et. al.
Intramolecular acyl migration and enzymatic hydrolysis of a novel monoacylated ascorbic acid derivative, 6- O-dodecanoyl-2- O-α- d-glucopyranosyl- l-ascorbic acid
score: 1.0092091, Bioorganic & Medicinal Chemistry, 2010, Tai, Akihiro et. al.
Induction of protein-like molecular architecture by self-assembly processes
score: 1.0091967, Bioorganic & Medicinal Chemistry, 1999, Fields, Gregg B.
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles
score: 1.009175, Bioorganic & Medicinal Chemistry, 2012, Holler, Jes Gitz et. al.
In search of novel water soluble forskolin analogues for positive inotropic activity
score: 1.0091617, Bioorganic & Medicinal Chemistry, 1998, Lal, Bansi et. al.
Molecular characterization of cefoxitin-resistant Escherichia coli from Canadian hospitals.
score: 1.0091396, Antimicrobial agents and chemotherapy, 2005, Mulvey, Michael R et. al.
Restoration of immune response by a cationic amphiphilic drug (AY 9944) in vitro: a new approach To chemotherapy against human immunodeficiency virus type 1.
score: 1.0090872, Antimicrobial agents and chemotherapy, 1998, Achour, A et. al.
In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis.
score: 1.0089515, Antimicrobial agents and chemotherapy, 1996, Narcisi, E M; Secor, W E
Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents
score: 1.0089155, Bioorganic & Medicinal Chemistry, 2012, Zhang, Zhi-Ming et. al.
Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents
score: 1.0089155, Bioorganic & Medicinal Chemistry, 2012, Zhang, Zhi-Ming et. al.
Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents
score: 1.0089155, Bioorganic & Medicinal Chemistry, 2012, Zhang, Zhi-Ming et. al.
Multidrug-resistant Salmonella enterica serovar Muenchen from pigs and humans and potential interserovar transfer of antimicrobial resistance.
score: 1.0088912, Antimicrobial agents and chemotherapy, 2005, Gebreyes, Wondwossen A; Thakur, Siddhartha
Synthesis and Biological Activity of a Photoaffinity Etoposide Probe
score: 1.0087908, Bioorganic & Medicinal Chemistry, 2001, Hasinoff, Brian B. et. al.
Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection.
score: 1.0087806, Antimicrobial agents and chemotherapy, 2008, Kiser, Jennifer J et. al.
Emergence of tetracycline resistance in Helicobacter pylori: multiple mutational changes in 16S ribosomal DNA and other genetic loci.
score: 1.008712, Antimicrobial agents and chemotherapy, 2002, Dailidiene, Daiva et. al.
Organocatalytic α-hydroxymethylation of cyclopentanone with aqueous formaldehyde: Easy access to chiral δ-lactones
score: 1.0086889, Bioorganic & Medicinal Chemistry Letters, 2009, Mase, Nobuyuki et. al.
Reduced clinical efficacy of pazufloxacin against gonorrhea due to high prevalence of quinolone-resistant isolates with the GyrA mutation. The Pazufloxacin STD Group.
score: 1.00865, Antimicrobial agents and chemotherapy, 1998, Tanaka, M et. al.
The benefits of the multi-target approach in drug design and discovery
score: 1.008631, Bioorganic & Medicinal Chemistry, 2006, Espinoza-Fonseca, L. Michel
Synthesis of the vancomycin CDE ring system
score: 1.0085976, Bioorganic & Medicinal Chemistry Letters, 1998, Boger, Dale L. et. al.
Effect of a selective decontamination of the digestive tract regimen including parenteral cefepime on establishment of intestinal colonization with vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice.
score: 1.0085881, Antimicrobial agents and chemotherapy, 2006, Paterson, David L; Stiefel, Usha; Donskey, Curtis J
Synthesis of new 2-galactosylthiazolidine-4-carboxylic acid amides. Antitumor evaluation against melanoma and breast cancer cells
score: 1.0085798, European Journal of Medicinal Chemistry, 2012, Serra, Arménio C. et. al.
Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999--2000, including a comparison of resistance rates since 1994--1995.
score: 1.0085764, Antimicrobial agents and chemotherapy, 2001, Doern, G V et. al.
ATP synthase is necessary for microcin H47 antibiotic action.
score: 1.0085237, Antimicrobial agents and chemotherapy, 2001, Trujillo, M; Rodríguez, E; Laviña, M
Using specificity to strategically target proteases
score: 1.0085071, Bioorganic & Medicinal Chemistry, 2009, Lim, Mark D.; Craik, Charles S.
ICESp2905, the erm(TR)-tet(O) Element of Streptococcus pyogenes, Is Formed by Two Independent Integrative and Conjugative Elements.
score: 1.0084698, Antimicrobial agents and chemotherapy, 2012, Giovanetti, Eleonora et. al.
Solid-phase, single nucleotide primer extension of DNA/RNA hybrids by reverse transcriptases
score: 1.0083422, Bioorganic & Medicinal Chemistry Letters, 2001, Pirrung, Michael C et. al.
Effect of natural polymorphisms in the HIV-1 CRF02_AG protease on protease inhibitor hypersusceptibility.
score: 1.0082647, Antimicrobial agents and chemotherapy, 2012, Santos, André F A et. al.
Mutation analysis of mycobacterial rpoB genes and rifampin resistance using recombinant Mycobacterium smegmatis.
score: 1.0082541, Antimicrobial agents and chemotherapy, 2012, Nakata, Noboru; Kai, Masanori; Makino, Masahiko
A physiologically based pharmacokinetic model for capreomycin.
score: 1.0082256, Antimicrobial agents and chemotherapy, 2012, Reisfeld, B et. al.
Lopinavir measurement in pleural effusion in a human immunodeficiency virus type 1-infected patient with kaposi's sarcoma.
score: 1.0082196, Antimicrobial agents and chemotherapy, 2002, Boffito, Marta et. al.
Synthesis of sialyl lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions
score: 1.008209, Bioorganic & Medicinal Chemistry, 1999, Lin, Chun-Cheng et. al.
Novel spectinomycin/streptomycin resistance gene, aadA14, from Pasteurella multocida.
score: 1.0081648, Antimicrobial agents and chemotherapy, 2005, Kehrenberg, Corinna et. al.
Microbial models of drug metabolism: microbial transformations of trimegestone® (RU27987), a 3-Keto-Δ 4,9(10)-19-norsteroid drug
score: 1.0081402, Bioorganic & Medicinal Chemistry, 1999, Lacroix, Isabelle; Biton, Jacques; Azerad, Robert
Design, synthesis and antitumor activities of novel 7-arylseleno-7-deoxydaunomycinone derivatives
score: 1.0081387, Bioorganic & Medicinal Chemistry, 2002, Zhang, Shu-Jia; Jia, Zheng-Ping; Wang, Yan-Guang
Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase.
score: 1.0080699, Antimicrobial agents and chemotherapy, 2008, Ruckenstuhl, Christoph et. al.
Interaction of the MexA and MexB components of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: identification of MexA extragenic suppressors of a T578I mutation in MexB.
score: 1.0080399, Antimicrobial agents and chemotherapy, 2005, Nehme, Dominic; Poole, Keith
Azithromycin exhibits bactericidal effects on Pseudomonas aeruginosa through interaction with the outer membrane.
score: 1.0080237, Antimicrobial agents and chemotherapy, 2005, Imamura, Yoshifumi et. al.
Synergistic in vitro interactions between alpha interferon and ribavirin against bovine viral diarrhea virus and yellow fever virus as surrogate models of hepatitis C virus replication.
score: 1.0080165, Antimicrobial agents and chemotherapy, 2003, Buckwold, Victor E et. al.
Total synthesis and antifungal evaluation of cyclic aminohexapeptides
score: 1.0079149, Bioorganic & Medicinal Chemistry, 2000, Klein, Larry L. et. al.
Functional correlation of molecular electronic properties with potency of synthetic carbinolamine antimalarial agents
score: 1.0079042, Bioorganic & Medicinal Chemistry, 1998, Bhattacharjee, Apurba K; Karle, Jean M
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa
score: 1.0078358, Bioorganic & Medicinal Chemistry, 2005, Orenes Lorente, Silvia et. al.
Candida albicans biofilms produce antifungal-tolerant persister cells.
score: 1.0077915, Antimicrobial agents and chemotherapy, 2006, LaFleur, Michael D; Kumamoto, Carol A; Lewis, Kim
Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: A chemical model for possible biologically relevant properties of molybdenum-containing enzymes
score: 1.007737, Bioorganic & Medicinal Chemistry Letters, 2012, Litvić, Mladen et. al.
Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: A chemical model for possible biologically relevant properties of molybdenum-containing enzymes
score: 1.007737, Bioorganic & Medicinal Chemistry Letters, 2012, Litvić, Mladen et. al.
Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: A chemical model for possible biologically relevant properties of molybdenum-containing enzymes
score: 1.007737, Bioorganic & Medicinal Chemistry Letters, 2012, Litvić, Mladen et. al.
Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage.
score: 1.0077145, Antimicrobial agents and chemotherapy, 2000, Tait-Kamradt, A et. al.
Generating short peptidic ligands for silver nanowires from phage display random libraries
score: 1.0077098, Bioorganic & Medicinal Chemistry Letters, 2006, Chan, Priscilla et. al.
Conformational flexibility and receptor interaction
score: 1.0076633, Bioorganic & Medicinal Chemistry, 1998, Janssen, Lambert H.M.
Insertion of mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637.
score: 1.007634, Antimicrobial agents and chemotherapy, 1999, Debets-Ossenkopp, Y J et. al.
Molecular evolution of beta-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan.
score: 1.0076054, Antimicrobial agents and chemotherapy, 2006, Sanbongi, Yumiko et. al.
Influence of the TonB energy-coupling protein on efflux-mediated multidrug resistance in Pseudomonas aeruginosa.
score: 1.0075696, Antimicrobial agents and chemotherapy, 1998, Zhao, Q et. al.
Impact of clarithromycin resistance on eradication of Helicobacter pylori in infected adults.
score: 1.0075449, Antimicrobial agents and chemotherapy, 2005, Lee, Jong Hwa et. al.
Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by antisense oligodeoxynucleotides.
score: 1.0074906, Antimicrobial agents and chemotherapy, 2003, Sarno, Renee et. al.
Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors
score: 1.0073917, BMC Bioinformatics, 2011, John, Shalini et. al.
Activities of gemifloxacin and five other antimicrobial agents against Listeria monocytogenes and coryneform bacteria isolated from clinical samples.
score: 1.0073714, Antimicrobial agents and chemotherapy, 2001, Martínez-Martínez, L; Joyanes, P; Suárez, A I; Perea, E J
Estimating the length of hospitalization attributable to multidrug antibiotic resistance.
score: 1.0073461, Antimicrobial agents and chemotherapy, 2010, Blot, Stijn et. al.
Genetic diversity of Tn916-related transposons among drug-resistant Streptococcus pneumoniae isolates colonizing healthy children in Venezuela.
score: 1.0073461, Antimicrobial agents and chemotherapy, 2011, Quintero, Beatríz et. al.
Self-propagating artificial transcription factors to enhance upregulation of target genes
score: 1.0073188, Bioorganic & Medicinal Chemistry Letters, 2010, Mori, Tomoaki et. al.
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
score: 1.0071792, Antimicrobial agents and chemotherapy, 2012, Buckner, Frederick S et. al.
C-Terminally PEGylated hGH-derivatives
score: 1.0071332, Bioorganic & Medicinal Chemistry, 2007, Peschke, Bernd et. al.
Thiourea compound AW00178 sensitizes human H1299 lung carcinoma cells to TRAIL-mediated apoptosis
score: 1.0071302, Bioorganic & Medicinal Chemistry Letters, 2012, Ryu, Byung Jun et. al.
Thiourea compound AW00178 sensitizes human H1299 lung carcinoma cells to TRAIL-mediated apoptosis
score: 1.0071302, Bioorganic & Medicinal Chemistry Letters, 2012, Ryu, Byung Jun et. al.
Thiourea compound AW00178 sensitizes human H1299 lung carcinoma cells to TRAIL-mediated apoptosis
score: 1.0071302, Bioorganic & Medicinal Chemistry Letters, 2012, Ryu, Byung Jun et. al.
Thiourea compound AW00178 sensitizes human H1299 lung carcinoma cells to TRAIL-mediated apoptosis
score: 1.0071302, Bioorganic & Medicinal Chemistry Letters, 2012, Ryu, Byung Jun et. al.
Joint population pharmacokinetic analysis of zidovudine, lamivudine, and their active intracellular metabolites in HIV patients.
score: 1.0071158, Antimicrobial agents and chemotherapy, 2011, Bazzoli, C et. al.
Antimicrobial susceptibility testing of 59 strains of Campylobacter fetus subsp. fetus.
score: 1.0069627, Antimicrobial agents and chemotherapy, 1998, Tremblay, C; Gaudreau, C
Updated sequence information for TEM beta-lactamase genes.
score: 1.0069589, Antimicrobial agents and chemotherapy, 1999, Goussard, S; Courvalin, P
Genetic basis of antibiotic resistance in clinical isolates of Streptococcus gallolyticus (Streptococcus bovis).
score: 1.0068889, Antimicrobial agents and chemotherapy, 2005, Leclercq, Roland et. al.
Mutations in the β subunit of RNA polymerase alter intrinsic cephalosporin resistance in Enterococci.
score: 1.0068519, Antimicrobial agents and chemotherapy, 2012, Kristich, Christopher J; Little, Jaime L
One-pot synthesis of functionalized 4,5-dihydroisoxazole derivatives via nitrile oxides and biological evaluation with plant cells
score: 1.0068214, Bioorganic & Medicinal Chemistry, 2004, Mincheva, Zoia et. al.
Rapid detection and estimation by pyrosequencing of 23S rRNA genes with a single nucleotide polymorphism conferring linezolid resistance in Enterococci.
score: 1.0067199, Antimicrobial agents and chemotherapy, 2003, Sinclair, Alistair; Arnold, Catherine; Woodford, Neil
Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.
score: 1.0067055, Antimicrobial agents and chemotherapy, 2010, Fortwendel, Jarrod R et. al.
Quantitative proteome analysis using D-labeled N-ethylmaleimide and 13C-labeled iodoacetanilide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
score: 1.0066846, Bioorganic & Medicinal Chemistry, 2006, Kurono, Sadamu et. al.
Potentiation of vancomycin-induced histamine release by muscle relaxants and morphine in rats.
score: 1.006683, Antimicrobial agents and chemotherapy, 1999, Shuto, H et. al.
Susceptibility testing of Malassezia species using the urea broth microdilution method.
score: 1.0066726, Antimicrobial agents and chemotherapy, 2000, Nakamura, Y; Kano, R; Murai, T; Watanabe, S; Hasegawa, A
Selection of high-level resistance to human immunodeficiency virus type 1 protease inhibitors.
score: 1.0066687, Antimicrobial agents and chemotherapy, 2003, Watkins, Terri et. al.
Validation of the intact zwittermicin A biosynthetic gene cluster and discovery of a complementary resistance mechanism in Bacillus thuringiensis.
score: 1.0066636, Antimicrobial agents and chemotherapy, 2011, Luo, Yi et. al.
Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation.
score: 1.0066538, Antimicrobial agents and chemotherapy, 2004, Desaki, Masashi et. al.
Structural basis for the design of novel Schiff base metal chelate inhibitors of trypsin
score: 1.0066273, Bioorganic & Medicinal Chemistry, 2010, Iyaguchi, Daisuke et. al.
Nonparametric population pharmacokinetic analysis of amikacin in neonates, infants, and children.
score: 1.0066145, Antimicrobial agents and chemotherapy, 2002, Tréluyer, J M; Merlé, Y; Tonnelier, S; Rey, E; Pons, G
Denaturing high-performance liquid chromatography detection of ribosomal mutations conferring macrolide resistance in gram-positive cocci.
score: 1.0065916, Antimicrobial agents and chemotherapy, 2004, Canu, Annie et. al.
Indinavir
score: 1.0065913, Bioorganic & Medicinal Chemistry, 1997,
DNA sequence analysis of regions surrounding blaCMY-2 from multiple Salmonella plasmid backbones.
score: 1.0065781, Antimicrobial agents and chemotherapy, 2004, Giles, W P et. al.
Anti-allergic activity of stilbenes from Korean rhubarb ( Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-α and IL-4 in RBL-2H3 cells
score: 1.0065653, Bioorganic & Medicinal Chemistry, 2004, Matsuda, Hisashi et. al.
Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI)
score: 1.0065442, Bioorganic & Medicinal Chemistry, 2008, Martínez, Alberto et. al.
A proposed molecular model for the interaction of calcineurin with the cyclosporin A– Cyclophilin a complex
score: 1.006503, Bioorganic & Medicinal Chemistry, 1999, Ivery, Michael T.G.
Common region CR1 for expression of antibiotic resistance genes.
score: 1.0064569, Antimicrobial agents and chemotherapy, 2006, Rodriguez-Martinez, Jose-Manuel et. al.
Synthesis and study of peptides with semirigid i and i+7 side-chain bridges designed for α-helix stabilization
score: 1.0064524, Bioorganic & Medicinal Chemistry, 1999, Yu, Chongxi; Taylor, John W.
Grayanane diterpenoids from the leaves of Craiobiodendron yunnanense
score: 1.0064368, Bioorganic & Medicinal Chemistry, 2005, Zhang, Hua-Ping; Wang, Li-Quan; Qin, Guo-Wei
The Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases.
score: 1.0064301, Antimicrobial agents and chemotherapy, 2000, Boschi, L et. al.
Synthesis and antitumor activity of cis-dichloroplatinum(II) complexes of 1-(2-aminophenyl)-1,2,3,4-tetrahydroisoquinolines
score: 1.0064144, European Journal of Medicinal Chemistry, 2006, Kuo, Chen-Yuan; Wu, Ming-Jung; Kuo, Yao-Haur
Characterization of a transmissible plasmid encoding VEB-1 and VIM-1 in Proteus mirabilis.
score: 1.0063911, Antimicrobial agents and chemotherapy, 2012, Papagiannitsis, C C et. al.
Impact of carbapenem resistance and receipt of active antimicrobial therapy on clinical outcomes of Acinetobacter baumannii bloodstream infections.
score: 1.0063596, Antimicrobial agents and chemotherapy, 2011, Esterly, John S et. al.
Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases.
score: 1.0063196, Antimicrobial agents and chemotherapy, 2006, Hong, Ying et. al.
Importance of infusion volume and pump characteristics in extended administration of ß-lactam antibiotics.
score: 1.0063064, Antimicrobial agents and chemotherapy, 2010, Claus, Barbara; Buyle, Franky; Robays, Hugo; Vogelaers, Dirk
Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens.
score: 1.0062903, Antimicrobial agents and chemotherapy, 2001, Juffermans, N P et. al.
Generation of superoxide radicals by copper–glutathione complexes: Redox-consequences associated with their interaction with reduced glutathione
score: 1.0062375, Bioorganic & Medicinal Chemistry, 2009, Speisky, Hernán et. al.
Comparison of anti-hepatitis B virus activities of lamivudine and clevudine by a quantitative assay.
score: 1.0060524, Antimicrobial agents and chemotherapy, 2003, Abdelhamed, Ayman M et. al.
An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases
score: 1.0060438, Bioorganic & Medicinal Chemistry, 2003, Brooke, Edward W et. al.
Tags for labeling protein N-termini with subtiligase for proteomics
score: 1.0060426, Bioorganic & Medicinal Chemistry Letters, 2008, Yoshihara, Hikari A.I.; Mahrus, Sami; Wells, James A.
Streptococcus pneumoniae Transposon Tn1545/Tn6003 Changes to Tn6002 Due to Spontaneous Excision in Circular Form of the erm(B)- and aphA3-Containing Macrolide-Aminoglycoside-Streptothricin (MAS) Element.
score: 1.0060033, Antimicrobial agents and chemotherapy, 2012, Palmieri, Claudio et. al.
Resistance mechanisms in an in vitro-selected amoxicillin-resistant strain of Helicobacter pylori.
score: 1.0059639, Antimicrobial agents and chemotherapy, 2006, Co, Edgie-Mark A; Schiller, Neal L
Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin resistance in isolates of Streptococcus pneumoniae.
score: 1.0059293, Antimicrobial agents and chemotherapy, 1998, Johnston, N J; De Azavedo, J C; Kellner, J D; Low, D E
Randomized, placebo-controlled trial of nonpegylated and pegylated forms of recombinant human alpha interferon 2a for suppression of dengue virus viremia in rhesus monkeys.
score: 1.0058815, Antimicrobial agents and chemotherapy, 2005, Ajariyakhajorn, C et. al.
CYP2B6 G516T polymorphism but not rifampin coadministration influences steady-state pharmacokinetics of efavirenz in human immunodeficiency virus-infected patients in South India.
score: 1.0057214, Antimicrobial agents and chemotherapy, 2009, Ramachandran, Geetha et. al.
Molecular Modelling and Cytotoxicity of Substituted Anthraquinones as Inhibitors of Human Telomerase
score: 1.0056611, Bioorganic & Medicinal Chemistry, 2002, Cairns, Donald et. al.
Macrolide resistance in Campylobacter jejuni and Campylobacter coli: molecular mechanism and stability of the resistance phenotype.
score: 1.0056217, Antimicrobial agents and chemotherapy, 2005, Gibreel, Amera et. al.
Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides
score: 1.0056129, European Journal of Medicinal Chemistry, 2006, Clerici, F. et. al.
Synthesis and cytotoxicity evaluation of pyridin[2,3- f]indole-2,4,9-trione and benz[ f]indole-2,4,9-trione derivatives
score: 1.0055873, Bioorganic & Medicinal Chemistry, 2003, Lee, Hyun-Jung et. al.
Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol
score: 1.0055413, European Journal of Medicinal Chemistry, 2010, You, Zhong-Lu; Ni, Li-Li; Shi, Da-Hua; Bai, Shun
Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol
score: 1.0055413, European Journal of Medicinal Chemistry, 2010, You, Zhong-Lu; Ni, Li-Li; Shi, Da-Hua; Bai, Shun
Synthesis of N-acridinyl- N′-alkylguanidines: Dramatic influence of amine to guanidine replacement on the physicochemical properties
score: 1.0055241, Bioorganic & Medicinal Chemistry Letters, 2008, Zeghida, Walid et. al.
Synthesis and antitumor activity of selected 7-alkylidene substituted cephems
score: 1.0054348, Bioorganic & Medicinal Chemistry, 2000, Veinberg, G. et. al.
Characteristics and population dynamics of mosaic penA allele-containing Neisseria gonorrhoeae isolates collected in Sydney, Australia, in 2007-2008.
score: 1.0053826, Antimicrobial agents and chemotherapy, 2010, Tapsall, John W; Ray, Sanghamitra; Limnios, Athena
Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist
score: 1.005277, Bioorganic & Medicinal Chemistry, 2012, Ban, Shintaro et. al.
Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist
score: 1.005277, Bioorganic & Medicinal Chemistry, 2012, Ban, Shintaro et. al.
Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist
score: 1.005277, Bioorganic & Medicinal Chemistry, 2012, Ban, Shintaro et. al.
The first steps. The attack on the carbonyl carbon of pyridoxal cofactor in pyridoxal-dependent enzymes
score: 1.0052679, Bioorganic & Medicinal Chemistry Letters, 2008, Sonnet, Philip E.; Mascavage, Linda M.; Dalton, David R.
High prevalence of extended-spectrum beta-lactamase-producing strains among blood isolates of Enterobacter spp. collected in a tertiary hospital during an 8-year period and their antimicrobial susceptibility patterns.
score: 1.0052631, Antimicrobial agents and chemotherapy, 2004, Pai, Hyunjoo et. al.
The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster.
score: 1.005232, Antimicrobial agents and chemotherapy, 2000, Patel, R et. al.
Growth hormone secretagogues derived from NN703 with hydrazidesas c-terminal
score: 1.0052284, European Journal of Medicinal Chemistry, 2000, Ankersen, Michael et. al.
Lung microdialysis study of levofloxacin in rats following intravenous infusion at steady state.
score: 1.0052206, Antimicrobial agents and chemotherapy, 2008, Marchand, Sandrine et. al.
In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model.
score: 1.0052129, Antimicrobial agents and chemotherapy, 2003, Andes, D; Marchillo, K; Stamstad, T; Conklin, R
Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation
score: 1.0052127, Bioorganic & Medicinal Chemistry, 2004, Bennett, Christopher J. et. al.
In vitro activity of clarithromycin against intracellular Helicobacter pylori.
score: 1.0052067, Antimicrobial agents and chemotherapy, 2001, Piccolomini, R et. al.
Synthesis and antifungal activity of cholesterol-hydrazone derivatives
score: 1.0050557, European Journal of Medicinal Chemistry, 2004, Loncle, Céline et. al.
Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits.
score: 1.0050013, Antimicrobial agents and chemotherapy, 1999, Callender, D P et. al.
Apparent weak efficacy of ivermectin for treatment of human toxocariasis.
score: 1.0049203, Antimicrobial agents and chemotherapy, 1998, Magnaval, J F
In vivo and in vitro studies of antibiotic release from and bacterial growth inhibition by antibiotic-impregnated polymethylmethacrylate hip spacers.
score: 1.0049037, Antimicrobial agents and chemotherapy, 2006, Kelm, Jens et. al.
Longitudinal use of a line probe assay for human immunodeficiency virus type 1 protease predicts phenotypic resistance and clinical progression in patients failing highly active antiretroviral therapy.
score: 1.004799, Antimicrobial agents and chemotherapy, 2002, Servais, Jean et. al.
Efficacy of amphiphilic core-shell nanostructures encapsulating gentamicin in an in vitro salmonella and listeria intracellular infection model.
score: 1.004786, Antimicrobial agents and chemotherapy, 2010, Ranjan, A et. al.
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
score: 1.0047715, Antimicrobial agents and chemotherapy, 2008, Howe, Anita Y M et. al.
In vitro and in vivo activities of the novel azole antifungal agent r126638.
score: 1.0046903, Antimicrobial agents and chemotherapy, 2004, Odds, F et. al.
Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice.
score: 1.0046053, Antimicrobial agents and chemotherapy, 2003, Quenelle, Debra C; Collins, Deborah J; Kern, Earl R
Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives
score: 1.0045734, Chemistry Central Journal, 2012, Osman, Hasnah et. al.
Mg 2+-mediated binding of 6-Substituted quinolones to DNA: relevance to biological activity
score: 1.0045676, Bioorganic & Medicinal Chemistry, 1998, Sissi, Claudia et. al.
Inhibition of intramacrophage growth of Penicillium marneffei by 4-aminoquinolines.
score: 1.004481, Antimicrobial agents and chemotherapy, 2001, Taramelli, D et. al.
Lack of synergy of erythromycin combined with penicillin or cefotaxime against Streptococcus pneumoniae in vitro.
score: 1.0044664, Antimicrobial agents and chemotherapy, 2003, Lin, Eugene; Stanek, Ronald J; Mufson, Maurice A
Activities of beta-lactams and macrolides against Helicobacter pylori.
score: 1.0044603, Antimicrobial agents and chemotherapy, 1999, Hassan, I J; Stark, R M; Greenman, J; Millar, M R
Prospectively validated dosing nomograms for maximizing the pharmacodynamics of vancomycin administered by continuous infusion in critically ill patients.
score: 1.0044571, Antimicrobial agents and chemotherapy, 2009, Pea, Federico et. al.
Stereoselective Detoxification of Chiral Sarin and Soman Analogues by Phosphotriesterase
score: 1.0044181, Bioorganic & Medicinal Chemistry, 2001, Li, Wen-Shan et. al.
Concentrations of tenofovir and emtricitabine in breast milk of HIV-1-infected women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2.
score: 1.0043367, Antimicrobial agents and chemotherapy, 2011, Benaboud, Sihem et. al.
Evaluation of nitrofurantoin combination therapy of metronidazole-sensitive and -resistant Helicobacter pylori infections in mice.
score: 1.0043081, Antimicrobial agents and chemotherapy, 2000, Jenks, P J et. al.
Structure–activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities
score: 1.0042823, Bioorganic & Medicinal Chemistry, 2000, Koul, Surrinder et. al.
Antifungal therapy of murine Aspergillus terreus infection.
score: 1.0042138, Antimicrobial agents and chemotherapy, 2004, Graybill, John R et. al.
Role of the PDR gene network in yeast susceptibility to the antifungal antibiotic mucidin.
score: 1.0042112, Antimicrobial agents and chemotherapy, 2000, Michalkova-Papajova, D; Obernauerova, M; Subik, J
Evaluation of new antituberculosis drugs in mouse models.
score: 1.0041982, Antimicrobial agents and chemotherapy, 2007, Davies, G R et. al.
Hydroxyurea is a carbonic anhydrase inhibitor
score: 1.0041791, Bioorganic & Medicinal Chemistry, 2003, Scozzafava, Andrea; Supuran, Claudiu T
A 1998 survey of extended-spectrum beta-lactamases in Enterobacteriaceae in France. The French Study Group.
score: 1.0039541, Antimicrobial agents and chemotherapy, 2000, De Champs, C; Sirot, D; Chanal, C; Bonnet, R; Sirot, J
Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities.
score: 1.0039394, Antimicrobial agents and chemotherapy, 2001, Zhang, K E et. al.
Disposition of intravenous pyrimethamine in healthy volunteers.
score: 1.0039321, Antimicrobial agents and chemotherapy, 2000, Almond, D S et. al.
Penetration of linezolid into soft tissues of healthy volunteers after single and multiple doses.
score: 1.0039307, Antimicrobial agents and chemotherapy, 2005, Dehghanyar, Pejman et. al.
Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells.
score: 1.003929, Antimicrobial agents and chemotherapy, 2012, Vandenbosch, Davy et. al.
Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria.
score: 1.0039038, Antimicrobial agents and chemotherapy, 2002, Brown-Elliott, Barbara A et. al.
Controlled release of PEG chain from gold nanorods: Targeted delivery to tumor
score: 1.0038998, Bioorganic & Medicinal Chemistry, 2010, Niidome, Takuro et. al.
Preparation of highly substituted γ-lactam follicle stimulating hormone receptor agonists
score: 1.0038949, Bioorganic & Medicinal Chemistry, 2005, Pelletier, Jeffrey C. et. al.
Impact of inactive empiric antimicrobial therapy on inpatient mortality and length of stay.
score: 1.0038156, Antimicrobial agents and chemotherapy, 2006, Scarsi, Kimberly K et. al.
Carbapenem susceptibility testing errors using three automated systems, disk diffusion, Etest, and broth microdilution and carbapenem resistance genes in isolates of Acinetobacter baumannii-calcoaceticus complex.
score: 1.0037664, Antimicrobial agents and chemotherapy, 2011, Markelz, Ana Elizabeth et. al.
A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells
score: 1.0037532, Bioorganic & Medicinal Chemistry, 2004, Akao, Yukihiro et. al.
Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli.
score: 1.0037369, Antimicrobial agents and chemotherapy, 2012, Singh, Renu et. al.
Interaction of genistein benzyl derivatives with lipid bilayers—fluorescence spectroscopic and calorimetric study
score: 1.0036756, Bioorganic & Medicinal Chemistry, 2009, Maniewska, J.; Grynkiewicz, G.; Szeja, W.; Hendrich, A.B.
Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules
score: 1.0036479, Bioorganic & Medicinal Chemistry, 2004, Manfredini, Stefano et. al.
The marC gene of Escherichia coli is not involved in multiple antibiotic resistance.
score: 1.0036293, Antimicrobial agents and chemotherapy, 2008, McDermott, Patrick F et. al.
Biochemical and functional characterization of an l-amino acid oxidase isolated from Bothrops pirajai snake venom
score: 1.003622, Bioorganic & Medicinal Chemistry, 2006, Izidoro, Luiz Fernando M. et. al.
Putative drug binding conformations of monoamine transporters
score: 1.0035812, Bioorganic & Medicinal Chemistry, 2006, Ravna, Aina Westrheim et. al.
Pharmacological basis for concentration-controlled therapy with zidovudine, lamivudine, and indinavir.
score: 1.0035811, Antimicrobial agents and chemotherapy, 2001, Kakuda, T N et. al.
Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by real-time PCR.
score: 1.0035785, Antimicrobial agents and chemotherapy, 2004, Branger, S; Rolain, J M; Raoult, D
DNA microarray for detection of macrolide resistance genes.
score: 1.0035374, Antimicrobial agents and chemotherapy, 2006, Cassone, Marco et. al.
first detection of trimethoprim resistance determinant dfrG in Streptococcus pyogenes clinical isolates in India.
score: 1.0035283, Antimicrobial agents and chemotherapy, 2012, Bergmann, René et. al.
Antileishmanial activity of a linalool-rich essential oil from Croton cajucara.
score: 1.0034355, Antimicrobial agents and chemotherapy, 2003, do Socorro S Rosa, Maria do Socorro S et. al.
New Role of the Disulfide Stress Effector YjbH in β-Lactam Susceptibility of Staphylococcus aureus.
score: 1.0033804, Antimicrobial agents and chemotherapy, 2011, Göhring, Nadine et. al.
Observational study of the clinical efficacy of voriconazole and its relationship to plasma concentrations in patients.
score: 1.0033324, Antimicrobial agents and chemotherapy, 2011, Troke, Peter F; Hockey, Hans P; Hope, William W
Reduced pupil diameter in volunteers on stable buprenorphine maintenance therapy with telaprevir: a drug-drug interaction involving p-glycoprotein at the blood-brain barrier?
score: 1.0032912, Antimicrobial agents and chemotherapy, 2012, Mégarbane, Bruno; Alhaddad, Hisham; Declèves, Xavier
Respiratory chain inhibition by fullerene derivatives: hydrogen peroxide production caused by fullerene derivatives and a respiratory chain system
score: 1.0032688, Bioorganic & Medicinal Chemistry, 2003, Mashino, Tadahiko et. al.
Complete DNA sequence, comparative genomics, and prevalence of an IncHI2 plasmid occurring among extraintestinal pathogenic Escherichia coli isolates.
score: 1.003235, Antimicrobial agents and chemotherapy, 2006, Johnson, Timothy J et. al.
Design and synthesis of an optimized positional scanning library of peptoids: identification of novel multidrug resistance reversal agents
score: 1.0031239, Bioorganic & Medicinal Chemistry, 2005, Masip, Isabel et. al.
Red Man Syndrome Adverse Reaction following Intravenous Infusion of Cefepime.
score: 1.0030695, Antimicrobial agents and chemotherapy, 2012, Panos, George et. al.
Relationship between antibiotic consumption and Clostridium difficile-associated diarrhea: an epidemiological note.
score: 1.0028917, Antimicrobial agents and chemotherapy, 2009, Kaier, Klaus; Frank, Uwe
Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects.
score: 1.0028883, Antimicrobial agents and chemotherapy, 2011, Cass, Robert T et. al.
Penetration of Candida biofilms by antifungal agents.
score: 1.0028478, Antimicrobial agents and chemotherapy, 2004, Al-Fattani, Mohammed A; Douglas, L Julia
Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli.
score: 1.0028077, Antimicrobial agents and chemotherapy, 1998, Vedantam, G et. al.
Prospective multicenter study of the impact of carbapenem resistance on mortality in Pseudomonas aeruginosa bloodstream infections.
score: 1.002728, Antimicrobial agents and chemotherapy, 2012, Peña, Carmen et. al.
Synthesis and evaluation of estradiol derivatives with 16α-(bromoalkylamide), 16α-(bromoalkyl) or 16α-(bromoalkynyl) side chain as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 without estrogenic activity
score: 1.0026795, Bioorganic & Medicinal Chemistry, 1996, Pelletier, Joëlle D; Poirier, Donald
Depletion of the squalene synthase (ERG9) gene does not impair growth of Candida glabrata in mice.
score: 1.0025976, Antimicrobial agents and chemotherapy, 2000, Nakayama, H; Izuta, M; Nakayama, N; Arisawa, M; Aoki, Y
In Vitro Effect of Malachite Green on Candida albicans Involves Multiple Pathways and Transcriptional Regulators UPC2 and STP2.
score: 1.0025883, Antimicrobial agents and chemotherapy, 2012, Dhamgaye, Sanjiveeni et. al.
Rapid direct detection of multiple rifampin and isoniazid resistance mutations in Mycobacterium tuberculosis in respiratory samples by real-time PCR.
score: 1.0025668, Antimicrobial agents and chemotherapy, 2004, Marín, Mercedes et. al.
Reaction of dopamine with d-glyceraldehyde under biomimetic conditions: stereoselective formation of tetrahydroisoquinolines and rate-accelerating effects of transition metal ions
score: 1.0025069, Bioorganic & Medicinal Chemistry, 1999, Manini, Paola et. al.
Synthesis, characterization and in vitro biological activity studies of Cu–M (M = Cu 2+, Co 2+, Ni 2+, Mn 2+, Zn 2+) bimetallic complexes
score: 1.0024822, European Journal of Medicinal Chemistry, 2006, Rupesh, K.R. et. al.
Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria.
score: 1.0024673, Antimicrobial agents and chemotherapy, 2000, Ezzet, F et. al.
Population pharmacokinetic analysis of voriconazole plasma concentration data from pediatric studies.
score: 1.0024655, Antimicrobial agents and chemotherapy, 2009, Karlsson, Mats O; Lutsar, Irja; Milligan, Peter A
Nomenclature of genes encoding aminoglycoside-modifying enzymes.
score: 1.0023373, Antimicrobial agents and chemotherapy, 1998, Vanhoof, R; Hannecart-Pokorni, E; Content, J
Two Structurally Distinct VanA Resistance Elements at Different Locations in a Glycopeptide-Resistant Strain of Enterococcus faecalis.
score: 1.0023373, Antimicrobial agents and chemotherapy, 2001, Tremlett, C H; Brown, D F; Palepou, M F; Woodford, N
Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core
score: 1.0022994, Bioorganic & Medicinal Chemistry Letters, 2012, Harini, Salakatte Thammaiah et. al.
Efficacies of quinupristin-dalfopristin combined with vancomycin in vitro and in experimental endocarditis due to methicillin-resistant Staphylococcus aureus in relation to cross-resistance to macrolides, lincosamides, and streptogramin B- type antibiotics.
score: 1.0022756, Antimicrobial agents and chemotherapy, 2002, Pavie, Juliette et. al.
Dissemination in Portugal of CTX-M-15-, OXA-1-, and TEM-1-producing Enterobacteriaceae strains containing the aac(6')-Ib-cr gene, which encodes an aminoglycoside- and fluoroquinolone-modifying enzyme.
score: 1.0021806, Antimicrobial agents and chemotherapy, 2006, Machado, Elisabete et. al.
Selective oxidation of sulfides to sulfoxides catalyzed by ruthenium (III) meso-tetraphenylporphyrin chloride in the presence of molecular oxygen
score: 1.0021595, Bioorganic & Medicinal Chemistry Letters, 2007, Zhou, Xian-Tai et. al.
Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[ a, g]fluorenylium derivative
score: 1.0021085, Bioorganic & Medicinal Chemistry Letters, 2004, Juskowiak, Bernard et. al.
Gold nanoparticles conjugated with monosaccharide-modified peptide for lectin detection
score: 1.001911, Bioorganic & Medicinal Chemistry Letters, 2012, Tsutsumi, Hiroshi et. al.
Gold nanoparticles conjugated with monosaccharide-modified peptide for lectin detection
score: 1.001911, Bioorganic & Medicinal Chemistry Letters, 2012, Tsutsumi, Hiroshi et. al.
In vitro activities of daptomycin, arbekacin, vancomycin, and gentamicin alone and/or in combination against glycopeptide intermediate-resistant Staphylococcus aureus in an infection model.
score: 1.0019016, Antimicrobial agents and chemotherapy, 2000, Akins, R L; Rybak, M J
Substrate specificity of N-acetylglucosaminyl(diphosphodolichol) N-acetylglucosaminyl transferase, a key enzyme in the dolichol pathway
score: 1.00188, Bioorganic & Medicinal Chemistry, 2001, Tai, Vincent W.-F; O'Reilly, Mary K; Imperiali, Barbara
Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy.
score: 1.0018054, Antimicrobial agents and chemotherapy, 2011, Shields, Ryan K et. al.
Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.
score: 1.0017987, Antimicrobial agents and chemotherapy, 2002, Iyobe, Shizuko et. al.
In vitro and in vivo effects of 14alpha-demethylase (ERG11) depletion in Candida glabrata.
score: 1.0017947, Antimicrobial agents and chemotherapy, 2001, Nakayama, H; Nakayama, N; Arisawa, M; Aoki, Y
Differences in the occurrence of two base pair variants of Tn1546 from vancomycin-resistant enterococci from humans, pigs, and poultry.
score: 1.0017693, Antimicrobial agents and chemotherapy, 1998, Jensen, L B
Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates.
score: 1.0017693, Antimicrobial agents and chemotherapy, 2006, Doloy, A et. al.
Tet protein hybrids.
score: 1.0017693, Antimicrobial agents and chemotherapy, 2005, Levy, Stuart B; McMurry, Laura M; Roberts, Marilyn C
Genetic resistance elements carrying mef subclasses other than mef(A) in Streptococcus pyogenes.
score: 1.0017693, Antimicrobial agents and chemotherapy, 2011, Del Grosso, Maria et. al.
Thr270Ile in embC (Rv3793) is not a marker for ethambutol resistance in the Mycobacterium tuberculosis complex.
score: 1.0017693, Antimicrobial agents and chemotherapy, 2011, Köser, Claudio U; Summers, David K; Archer, John A C
Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits.
score: 1.0017693, Antimicrobial agents and chemotherapy, 1998, Musafija, A; Barzilai, A; Ramon, J; Rubinstein, E
Determination of the genetic support for tet(W) in oral bacteria.
score: 1.0017693, Antimicrobial agents and chemotherapy, 2007, Villedieu, A et. al.
SmaI typeability and tetracycline susceptibility and resistance in Streptococcus pyogenes isolates with efflux-mediated erythromycin resistance.
score: 1.0017693, Antimicrobial agents and chemotherapy, 2007, Bacciaglia, A; Brenciani, A; Varaldo, P E; Giovanetti, E
Reply to "Genetic Contexts of blaNDM-1".
score: 1.0017693, Antimicrobial agents and chemotherapy, 2012, Toleman, M A; Walsh, T R
The solution structure of a lasalocid A metal complex in lipophilic solvents
score: 1.0017689, Bioorganic & Medicinal Chemistry, 2005, Ripoli, Silvia et. al.
A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone
score: 1.0017601, Bioorganic & Medicinal Chemistry Letters, 2004, Heinrich, Timo; Böttcher, Henning
[Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents
score: 1.0017432, European Journal of Medicinal Chemistry, 2010, Rubner, Gerhard et. al.
Bovine lactoferrin inhibits adenovirus infection by interacting with viral structural polypeptides.
score: 1.0017116, Antimicrobial agents and chemotherapy, 2003, Pietrantoni, Agostina et. al.
Pharmacokinetics of stavudine and didanosine coadministered with nelfinavir in human immunodeficiency virus-exposed neonates.
score: 1.0017084, Antimicrobial agents and chemotherapy, 2001, Rongkavilit, C et. al.
Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents.
score: 1.0017016, Antimicrobial agents and chemotherapy, 2001, Credito, K L et. al.
Antimicrobial resistance in fecal Escherichia coli isolates from healthy urban children of two age groups in relation to their antibiotic therapy.
score: 1.0016466, Antimicrobial agents and chemotherapy, 2011, Literak, Ivan et. al.
Mosaic staphylococcal cassette chromosome mec containing two recombinase loci and a new mec complex, B2.
score: 1.0016379, Antimicrobial agents and chemotherapy, 2007, Heusser, R; Ender, M; Berger-Bächi, B; McCallum, N
Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.
score: 1.0015776, Antimicrobial agents and chemotherapy, 2000, Ishikawa, J; Sunada, A; Oyama, R; Hotta, K
Efficacy of ciprofloxacin in an experimental model of Escherichia coli chorioamnionitis in rabbits.
score: 1.0015312, Antimicrobial agents and chemotherapy, 2009, Launay, Elise et. al.
Modulation of human α-thrombin activity with phosphonate ester inhibitors
score: 1.0014619, Bioorganic & Medicinal Chemistry, 1997, Enyedy, Edith J.; Kovach, Ildiko M.
Modulation of human α-thrombin activity with phosphonate ester inhibitors
score: 1.0014619, Bioorganic & Medicinal Chemistry, 1997, Enyedy, Edith J.; Kovach, Ildiko M.
Spread of the qnrVC quinolone resistance determinant in Vibrio cholerae.
score: 1.0014563, Antimicrobial agents and chemotherapy, 2011, da Fonseca, Erica Lourenço; Vicente, Ana Carolina Paulo
Transposons Tn1696 and Tn21 and their integrons In4 and In2 have independent origins.
score: 1.0014081, Antimicrobial agents and chemotherapy, 2001, Partridge, S R; Brown, H J; Stokes, H W; Hall, R M
Optimization of blends of synthetic pheromone components for trapping male limabean pod borers ( Etiella zinckenella Tr.) (Lepidoptera: Phycitidae): Preliminary evidence on geographical differences
score: 1.0013324, Bioorganic & Medicinal Chemistry, 1996, Tóth, M.; Talekar, N.S.; Szöcs, G.
High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae.
score: 1.0012936, Antimicrobial agents and chemotherapy, 2000, Rice, L B et. al.
Pharmacokinetics of Rifampin in Peruvian Tuberculosis Patients with and without Comorbid Diabetes or HIV.
score: 1.0012779, Antimicrobial agents and chemotherapy, 2012, Requena-Méndez, Ana et. al.
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds
score: 1.0012427, European Journal of Medicinal Chemistry, 2002, Dimmock, Jonathan R et. al.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
score: 1.0012278, Antimicrobial agents and chemotherapy, 2008, Empel, Joanna et. al.
Bacteriocin production in vancomycin-resistant and vancomycin-susceptible Enterococcus isolates of different origins.
score: 1.0012213, Antimicrobial agents and chemotherapy, 2001, del Campo, R et. al.
Design, synthesis and biological evaluation of selective boron-containing thrombin inhibitors
score: 1.0010368, Bioorganic & Medicinal Chemistry, 1999, Wienand, Anette et. al.
Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents
score: 1.0010349, European Journal of Medicinal Chemistry, 2005, Perillo, Isabel et. al.
Enabling ScFvs as multi-drug carriers: A dendritic approach
score: 1.0010298, Bioorganic & Medicinal Chemistry, 2003, Sun, Chengzao; Wirsching, Peter; Janda, Kim D
Acanthamoeba polyphaga strain age and method of cyst production influence the observed efficacy of therapeutic agents and contact lens disinfectants.
score: 1.0009044, Antimicrobial agents and chemotherapy, 2003, Hughes, Reanne; Heaselgrave, Wayne; Kilvington, Simon
Scopulariopsis brevicaulis, a fungal pathogen resistant to broad-spectrum antifungal agents.
score: 1.0008026, Antimicrobial agents and chemotherapy, 2003, Cuenca-Estrella, Manuel et. al.
Comparative effects of ciprofloxacin and ceftazidime on cytokine production in patients with severe sepsis caused by gram-negative bacteria.
score: 1.0007512, Antimicrobial agents and chemotherapy, 2004, Gogos, C A et. al.
Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: From molecular modeling to in vivo evaluation
score: 1.0007424, Bioorganic & Medicinal Chemistry, 2010, Brillouet, Séverine et. al.
Mechanisms of quinolone resistance in clinical isolates of Shigella dysenteriae.
score: 1.0007285, Antimicrobial agents and chemotherapy, 1999, Ahamed, J; Gangopadhyay, J; Kundu, M; Sinha, A K
On the mechanism of microsomal prostaglandin E synthase type-2—A theoretical study of endoperoxide reaction with MeS −
score: 1.0007048, Bioorganic & Medicinal Chemistry Letters, 2010, Li, Yi et. al.
Substituted dibenzo[ c,h]cinnolines: topoisomerase I-targeting anticancer agents
score: 1.000682, Bioorganic & Medicinal Chemistry, 2003, Yu, Younong et. al.
Rapid and efficient oxidation of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by manganese (III) Schiff base complexes
score: 1.0006671, Bioorganic & Medicinal Chemistry, 2006, Nasr-Esfahani, Masoud et. al.
Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin
score: 1.0005696, Bioorganic & Medicinal Chemistry, 2005, Pajewski, Robert et. al.
R57K polymorphism in the human immunodeficiency virus type 1 protease as predictor of early virological failure in a cohort of antiretroviral-naive patients treated mostly with a nelfinavir-containing regimen.
score: 1.0005212, Antimicrobial agents and chemotherapy, 2003, Masquelier, Bernard et. al.
Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt γ-class enzyme from the archaeon Methanosarcina thermophila with anions
score: 1.0003995, Bioorganic & Medicinal Chemistry Letters, 2004, Innocenti, Alessio et. al.
Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases
score: 1.0003704, Bioorganic & Medicinal Chemistry Letters, 1998, Massova, Irina; Kotra, Lakshmi P.; Mobashery, Shahriar
Susceptibility of Cryptococcus neoformans to photodynamic inactivation is associated with cell wall integrity.
score: 1.0003675, Antimicrobial agents and chemotherapy, 2007, Fuchs, Beth Burgwyn et. al.
Intrapatient variability of efavirenz concentrations as a predictor of virologic response to antiretroviral therapy.
score: 1.0003436, Antimicrobial agents and chemotherapy, 2004, Brundage, Richard C et. al.
Synthesis and biological evaluation of new GABA-uptake inhibitors derived from proline and from pyrrolidine-2-acetic acid
score: 1.000343, European Journal of Medicinal Chemistry, 2005, Zhao, Xueqing et. al.
In vitro activities of eight macrolide antibiotics and RP-59500 (quinupristin-dalfopristin) against viridans group streptococci isolated from blood of neutropenic cancer patients.
score: 1.0003046, Antimicrobial agents and chemotherapy, 1996, Alcaide, F; Carratala, J; Liñares, J; Gudiol, F; Martin, R
Population pharmacokinetics of extended-infusion piperacillin-tazobactam in hospitalized patients with nosocomial infections.
score: 1.000187, Antimicrobial agents and chemotherapy, 2012, Felton, T W et. al.
Selection and persistence of CTX-M-producing Escherichia coli in the intestinal flora of pigs treated with amoxicillin, ceftiofur, or cefquinome.
score: 1.0000483, Antimicrobial agents and chemotherapy, 2008, Cavaco, L M; Abatih, E; Aarestrup, F M; Guardabassi, L
Theoretical elucidation on structure–Antioxidant activity relationships for indolinonic hydroxylamines
score: 1.0000306, Bioorganic & Medicinal Chemistry Letters, 2002, Zhang, Hong-Yu; Wang, Lan-Fen
A promising target for treatment of multidrug-resistant bacterial infections.
score: 1.0000267, Antimicrobial agents and chemotherapy, 2011, Davey, Martin S et. al.
Theoretical proton affinities of α1 adrenoceptor ligands
score: 0.99994657, Bioorganic & Medicinal Chemistry, 2006, Kinsella, Gemma K.; Watson, Graeme W.; Rozas, Isabel
In vitro activities of terbinafine against cutaneous isolates of Candida albicans and other pathogenic yeasts.
score: 0.99989862, Antimicrobial agents and chemotherapy, 1998, Ryder, N S; Wagner, S; Leitner, I
In vitro and in vivo bacteriolytic activities of Escherichia coli phages: implications for phage therapy.
score: 0.99989328, Antimicrobial agents and chemotherapy, 2004, Chibani-Chennoufi, Sandra et. al.
The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc.
score: 0.99982209, Antimicrobial agents and chemotherapy, 2012, Sobke, A et. al.
α-Selective glycosylation with 5-thioglucopyranosyl donors; synthesis of an IsoMaltotetraoside mimic composed of 5-thioglucopyranose units
score: 0.99978509, Bioorganic & Medicinal Chemistry Letters, 2003, Matsuda, Hiroko et. al.
Susceptibilities of oral and nasal isolates of Streptococcus mitis and Streptococcus oralis to macrolides and PCR detection of resistance genes.
score: 0.99976823, Antimicrobial agents and chemotherapy, 2000, Ono, T et. al.
A radio frequency electric current enhances antibiotic efficacy against bacterial biofilms.
score: 0.99974809, Antimicrobial agents and chemotherapy, 2004, Caubet, R et. al.
Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis.
score: 0.99940236, Antimicrobial agents and chemotherapy, 2011, Hachmann, Anna-Barbara et. al.
Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate.
score: 0.99933453, Antimicrobial agents and chemotherapy, 1998, Haimeur, A; Ouellette, M
Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: noncovalent binding coincidental with alkylation
score: 0.9992591, Bioorganic & Medicinal Chemistry, 1996, Boger, Dale L.; Zhou, Jiacheng; Cai, Hui
Susceptibility of Chlamydia trachomatis to chlorhexidine gluconate gel.
score: 0.99922992, Antimicrobial agents and chemotherapy, 1998, Lampe, M F; Ballweber, L M; Stamm, W E
Pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects after single and multiple doses of a novel formulation.
score: 0.99922796, Antimicrobial agents and chemotherapy, 2006, Mouton, J W et. al.
Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker
score: 0.99922267, Bioorganic & Medicinal Chemistry Letters, 2009, Chu, Taiwei; Li, Zejun; Wang, Xiangyun
Paclitaxel binding to the fatty acid-induced conformation of human serum albumin—Automated docking studies
score: 0.99918398, Bioorganic & Medicinal Chemistry, 2007, Paal, Krisztina; Shkarupin, Aliaksei
Mycobacterium tuberculosis in the extracellular compartment: an underestimated adversary.
score: 0.99912605, Antimicrobial agents and chemotherapy, 2003, Grosset, Jacques
Allele-specific rpoB PCR assays for detection of rifampin-resistant Mycobacterium tuberculosis in sputum smears.
score: 0.99912522, Antimicrobial agents and chemotherapy, 2003, Mokrousov, Igor et. al.
The enhancement of neutron irradiation of HeLa-S cervix carcinoma cells by cell–nucleus-addressed deca- p-boronophenylalanine
score: 0.99909833, European Journal of Medicinal Chemistry, 2003, Braun, Klaus et. al.
Bioconversion of silybin to phase I & II microbial metabolites with retained antioxidant activity
score: 0.99903754, Bioorganic & Medicinal Chemistry, 2012, Abourashed, Ehab A.; Mikell, Julie R.; Khan, Ikhlas A.
In vitro antimicrobial susceptibility of Brachyspira pilosicoli isolates from humans.
score: 0.99900194, Antimicrobial agents and chemotherapy, 2003, Brooke, C J; Hampson, D J; Riley, T V
Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009.
score: 0.99899022, Antimicrobial agents and chemotherapy, 2011, Mehta, Supriya D et. al.
CMY-2-producing Escherichia coli in the nose of pigs.
score: 0.99897605, Antimicrobial agents and chemotherapy, 2012, Endimiani, Andrea; Hilty, Markus; Perreten, Vincent
DNA polymerase bypass in vitro and in E. coli of a C-nucleotide analogue of Fapy·dG
score: 0.99894874, Bioorganic & Medicinal Chemistry, 2008, Weledji, Yvonne N. et. al.
Use of international units when dosing colistin will help decrease confusion related to various formulations of the drug around the world.
score: 0.99892898, Antimicrobial agents and chemotherapy, 2006, Falagas, Matthew E; Kasiakou, Sofia K
Role of small bioorganic molecules in stem cell differentiation to insulin-producing cells
score: 0.99889078, Bioorganic & Medicinal Chemistry, 2006, Roche, Enrique et. al.
Historical yearly usage of vancomycin.
score: 0.99888817, Antimicrobial agents and chemotherapy, 1998, Kirst, H A; Thompson, D G; Nicas, T I
Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a pharmacokinetic study.
score: 0.99885595, Antimicrobial agents and chemotherapy, 2012, Batty, Kevin T et. al.
Structure–activity relationship study of nitrosopyrimidines acting as antifungal agents
score: 0.99883176, Bioorganic & Medicinal Chemistry, 2012, Olivella, Monica et. al.
MepR, a repressor of the Staphylococcus aureus MATE family multidrug efflux pump MepA, is a substrate-responsive regulatory protein.
score: 0.99882757, Antimicrobial agents and chemotherapy, 2006, Kaatz, Glenn W; DeMarco, Carmen E; Seo, Susan M
Bile acid–oligodeoxynucleotide conjugates: synthesis and liver excretion in rats
score: 0.99882442, Bioorganic & Medicinal Chemistry Letters, 2001, Starke, Dieter et. al.
Pyruvate decarboxylase, the target for omeprazole in metronidazole-resistant and iron-restricted Tritrichomonas foetus.
score: 0.9987844, Antimicrobial agents and chemotherapy, 2004, Sutak, Róbert; Tachezy, Jan; Kulda, Jaroslav; Hrdý, Ivan
Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida.
score: 0.99877841, Antimicrobial agents and chemotherapy, 2003, Sørum, Henning et. al.
Interaction of cyanine dyes with nucleic acids. XII.β-substituted carbocyanines as possible fluorescent probes for nucleic acids detection
score: 0.9987066, Bioorganic & Medicinal Chemistry Letters, 1999, Yarmoluk, Sergiy M et. al.
Effects of chemical and physical agents on viability and infectivity of Encephalitozoon intestinalis determined by cell culture and flow cytometry.
score: 0.99868132, Antimicrobial agents and chemotherapy, 2002, Santillana-Hayat, Maud et. al.
Clinical and antimicrobial susceptibility data of 140 Streptococcus pseudopneumoniae isolates in France.
score: 0.99867735, Antimicrobial agents and chemotherapy, 2012, Laurens, C et. al.
QSAR study on para-substituted aromatic sulfonamides as carbonic anhydrase II inhibitors using topological information indices
score: 0.99863757, Bioorganic & Medicinal Chemistry, 2006, Melagraki, Georgia et. al.
Residual activity of two HIV antiretroviral regimens prescribed without virological monitoring.
score: 0.99858903, Antimicrobial agents and chemotherapy, 2011, Dunn, D T et. al.
Drug resistance is not directly affected by mating type locus zygosity in Candida albicans.
score: 0.99855352, Antimicrobial agents and chemotherapy, 2003, Pujol, Claude et. al.
Potential latent nitrogen mustard derivatives designed to target monoamine oxidase rich cells
score: 0.99836367, Bioorganic & Medicinal Chemistry, 1997, Wang, You-Xiong; Castagnoli, Neal
Embodying a stable α-helical protein structure through efficient chemical ligation via thioether formation
score: 0.99829259, Bioorganic & Medicinal Chemistry, 1997, Futaki, Shiroh et. al.
Relationship between triclosan and susceptibilities of bacteria isolated from hands in the community.
score: 0.99816296, Antimicrobial agents and chemotherapy, 2004, Aiello, Allison E et. al.
Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruzi.
score: 0.99812771, Antimicrobial agents and chemotherapy, 1998, Michailowsky, V et. al.
Impact of burden on granulocyte clearance of bacteria in a mouse thigh infection model.
score: 0.99809969, Antimicrobial agents and chemotherapy, 2010, Drusano, G L et. al.
Comparative antimicrobial activities of the newly synthesized quinolone WQ-3034, levofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex.
score: 0.99809482, Antimicrobial agents and chemotherapy, 2000, Tomioka, H; Sato, K; Kajitani, H; Akaki, T; Shishido, S
Moxifloxacin treatment of tuberculosis.
score: 0.99807662, Antimicrobial agents and chemotherapy, 2004, Gosling, Roland; Gillespie, Stephen
Preliminary 1H NMR investigation of sialic acid transfer by the trans-sialidase from Trypanosoma cruzi
score: 0.9980014, Bioorganic & Medicinal Chemistry Letters, 2000, Wilson, Jennifer C et. al.
In vitro comparison of terbinafine and itraconazole against Penicillium marneffei.
score: 0.99793365, Antimicrobial agents and chemotherapy, 2000, McGinnis, M R; Nordoff, N G; Ryder, N S; Nunn, G B
What should be the first-choice strategy to maximize posaconazole exposure in daily clinical practice?
score: 0.99792531, Antimicrobial agents and chemotherapy, 2009, Pea, Federico; Furlanut, Mario; Viale, Pierluigi
Nitazoxanide in treatment of Helicobacter pylori: a clinical and in vitro study.
score: 0.99790998, Antimicrobial agents and chemotherapy, 2003, Guttner, Yvonne et. al.
Validation of a noninvasive, real-time imaging technology using bioluminescent Escherichia coli in the neutropenic mouse thigh model of infection.
score: 0.99779155, Antimicrobial agents and chemotherapy, 2001, Rocchetta, H L et. al.
Cu-free cycloaddition for identifying catalytic active adenylation domains of nonribosomal peptide synthetases by phage display
score: 0.99776601, Bioorganic & Medicinal Chemistry Letters, 2008, Zou, Yekui; Yin, Jun
In vitro synergistic interaction between amphotericin B and pentamidine against Scedosporium prolificans.
score: 0.99775862, Antimicrobial agents and chemotherapy, 2002, Afeltra, Javier et. al.
Inhibition of rev·RRE complexation by triplex tethered oligonucleotide probes
score: 0.99773287, Bioorganic & Medicinal Chemistry, 1997, Moses, Arikha C.; Huang, Suena W.; Schepartz, Alanna
Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa.
score: 0.99764727, Antimicrobial agents and chemotherapy, 2008, McCollum, Andrea M et. al.
Antibiotic-induced cell wall fragments of Staphylococcus aureus increase endothelial chemokine secretion and adhesiveness for granulocytes.
score: 0.99764525, Antimicrobial agents and chemotherapy, 1999, van Langevelde, P et. al.
Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of Salmonella enterica serovar Kentucky.
score: 0.99757038, Antimicrobial agents and chemotherapy, 2008, Doublet, Benoît et. al.
NDM-1-producing Acinetobacter baumannii from Algeria.
score: 0.99753671, Antimicrobial agents and chemotherapy, 2012, Boulanger, Anne et. al.
In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.
score: 0.99750065, Antimicrobial agents and chemotherapy, 2006, Vidal, Francesc et. al.
Outbreaks associated with contaminated antiseptics and disinfectants.
score: 0.99749164, Antimicrobial agents and chemotherapy, 2007, Weber, David J; Rutala, William A; Sickbert-Bennett, Emily E
Complementarity-determining region 3 size spectratypes of T cell receptor beta chains in CD8+ T cells following antiviral treatment of chronic hepatitis B.
score: 0.99749022, Antimicrobial agents and chemotherapy, 2011, Ma, Shi-Wu et. al.
Community-acquired liver abscess caused by serotype K1 Klebsiella pneumoniae with CTX-M-15-type extended-spectrum beta-lactamase.
score: 0.9974704, Antimicrobial agents and chemotherapy, 2008, Su, Sheng-Chiang et. al.
Identification of beta-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae with four methods and eight media.
score: 0.99742608, Antimicrobial agents and chemotherapy, 2001, Barry, A L; Fuchs, P C; Brown, S D
Candida glabrata mutants demonstrating paradoxical reduced caspofungin susceptibility but increased micafungin susceptibility.
score: 0.99737509, Antimicrobial agents and chemotherapy, 2011, Healey, Kelley R et. al.
Comparative study of mechanisms of herpes simplex virus inactivation by sodium lauryl sulfate and n-lauroylsarcosine.
score: 0.99732189, Antimicrobial agents and chemotherapy, 2002, Piret, Jocelyne et. al.
Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter.
score: 0.99731933, Antimicrobial agents and chemotherapy, 2003, Changsen, Chartchai et. al.
Stereo-enriched phosphorothioate oligodeoxynucleotides: synthesis, biophysical and biological properties
score: 0.99731799, Bioorganic & Medicinal Chemistry, 2000, Yu, Dong et. al.
PEG-scutellarin prodrugs: Synthesis, water solubility and protective effect on cerebral ischemia/reperfusion injury
score: 0.99720954, European Journal of Medicinal Chemistry, 2010, Lu, Juan et. al.
Antimicrobial therapy for bacillus anthracis-induced polymicrobial infection in (60)Co gamma-irradiated mice.
score: 0.99719912, Antimicrobial agents and chemotherapy, 2002, Elliott, Thomas B et. al.
Validation of the INNO-LiPA HBV DR assay (version 2) in monitoring hepatitis B virus-infected patients receiving nucleoside analog treatment.
score: 0.9971116, Antimicrobial agents and chemotherapy, 2010, Niesters, H G M et. al.
Pharmacokinetics of and short-term virologic response to low-dose 400-milligram once-daily raltegravir maintenance therapy.
score: 0.99709362, Antimicrobial agents and chemotherapy, 2012, Ananworanich, Jintanat et. al.
Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties
score: 0.99705, European Journal of Medicinal Chemistry, 2003, Teresa Cocco, Maria et. al.
Plasma concentrations of posaconazole administered via nasogastric tube in patients in a surgical intensive care unit.
score: 0.99697208, Antimicrobial agents and chemotherapy, 2012, Störzinger, Dominic et. al.
Risk factors for acquisition of multidrug-resistant Pseudomonas aeruginosa producing SPM metallo-beta-lactamase.
score: 0.9969608, Antimicrobial agents and chemotherapy, 2005, Nouér, Simone Aranha et. al.
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: a comparative study.
score: 0.99688478, Antimicrobial agents and chemotherapy, 2011, Roy Chowdhury, Piklu et. al.
Oxidatively induced Cu for Mn exchange in protein phosphatase 1γ: A new method for active site analysis
score: 0.99687575, Bioorganic & Medicinal Chemistry, 2009, Miyazaki, Atsushi et. al.
Stereospecificity of Pseudomonas fluorescens kynureninase for diastereomers of β-methylkynurenine
score: 0.99677382, Bioorganic & Medicinal Chemistry, 1999, Cyr, Lakshmi V.; Newton, M.Gary; Phillips, Robert S.
Functional molecules based on polyazometals. (1) artificial metalloproteinases prepared by conjugation of polyazometals with poly(allylamine)
score: 0.9967705, Bioorganic & Medicinal Chemistry Letters, 1998, Suh, Junghun; Moon, Sung Joo
Effect of ceftazidime on systemic cytokine concentrations in rats.
score: 0.99676346, Antimicrobial agents and chemotherapy, 2000, Alkharfy, K M; Kellum, J A; Frye, R F; Matzke, G R
Antibacterial effects of levofloxacin, erythromycin, and rifampin in a human monocyte system against Legionella pneumophila.
score: 0.99672577, Antimicrobial agents and chemotherapy, 1998, Baltch, A L; Smith, R P; Franke, M A; Michelsen, P B
Novel Fosfomycin resistance of Pseudomonas aeruginosa clinical isolates recovered in Japan in 1996.
score: 0.99659289, Antimicrobial agents and chemotherapy, 2000, Shimizu, M et. al.
Synthesis, crystal structures, biological activities and fluorescence studies of transition metal complexes with 3-carbaldehyde chromone thiosemicarbazone
score: 0.99657083, European Journal of Medicinal Chemistry, 2010, Li, Yong; Yang, Zheng-Yin; Wu, Jin-Cai
Exploring platelet chemokine antimicrobial activity: nuclear magnetic resonance backbone dynamics of NAP-2 and TC-1.
score: 0.99647424, Antimicrobial agents and chemotherapy, 2011, Nguyen, Leonard T et. al.
Fluoroquinolone resistance in invasive Streptococcus pyogenes isolates due to spontaneous mutation and horizontal gene transfer.
score: 0.99644266, Antimicrobial agents and chemotherapy, 2006, Pletz, M W R et. al.
Systematic synthesis of four epicatechin series procyanidin trimers and their inhibitory activity on the Maillard reaction and antioxidant activity
score: 0.99642239, Bioorganic & Medicinal Chemistry, 2004, Saito, Akiko et. al.
Synthesis and biological evaluation of 2,6-di- tert-butylphenol hydrazones as 5-lipoxygenase inhibitors
score: 0.99632263, Bioorganic & Medicinal Chemistry, 1998, Cuadro, Ana M et. al.
Synthesis of radioiodine labeled dibenzyl disulfide for evaluation of tumor cell uptake
score: 0.99629265, Bioorganic & Medicinal Chemistry, 2004, Ryu, Eun Kyoung et. al.
Synthesis of a disulfide-linked octameric peptide construct carrying three different antigenic determinants
score: 0.99629065, Bioorganic & Medicinal Chemistry Letters, 2001, Kragol, Goran et. al.
The synthesis and properties of new 2-pyrrolylthiones as chelating agents for transition metals and technetium
score: 0.99610579, Bioorganic & Medicinal Chemistry Letters, 2001, Selivanova, Svetlana V et. al.
Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes
score: 0.99607037, Bioorganic & Medicinal Chemistry Letters, 2004, Navarro, Aude-Emmanuelle et. al.
The preparation and antioxidant activity of the sulfanilamide derivatives of chitosan and chitosan sulfates
score: 0.99600735, Bioorganic & Medicinal Chemistry, 2007, Zhong, Zhimei et. al.
Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects.
score: 0.99600709, Antimicrobial agents and chemotherapy, 2012, Villano, Stephen A et. al.
DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer
score: 0.99597771, Bioorganic & Medicinal Chemistry, 2006, Kamal, Ahmed et. al.
Synthesis and pharmacological evaluation of new arylpiperazines. 3-{4-[4-(3-chlorophenyl)-1-piperazinyl]butyl}-quinazolidin-4-one — a dual serotonin 5-HT 1A/5-HT 2A receptor ligand with an anxiolytic-like activity
score: 0.99593919, Bioorganic & Medicinal Chemistry, 2002, Bojarski, Andrzej J et. al.
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.
score: 0.99592205, Antimicrobial agents and chemotherapy, 2011, Gilbert, Christian et. al.
Efficacy of liposomal amphotericin B with prolonged circulation in blood in treatment of severe pulmonary aspergillosis in leukopenic rats.
score: 0.99591828, Antimicrobial agents and chemotherapy, 2000, Van Etten, E W et. al.
Genetic identification of the bacteriocins produced by Enterococcus faecium IT62 and evidence that bacteriocin 32 is identical to enterocin IT.
score: 0.99591073, Antimicrobial agents and chemotherapy, 2009, Izquierdo, Esther et. al.
Risk factors for piperacillin-tazobactam-resistant Pseudomonas aeruginosa among hospitalized patients.
score: 0.99588377, Antimicrobial agents and chemotherapy, 2002, Harris, Anthony D et. al.
Synthesis and DNA cleavage activities of mononuclear macrocyclic polyamine zinc(II), copper(II), cobalt(II) complexes which linked with uracil
score: 0.99587616, Bioorganic & Medicinal Chemistry, 2006, Wang, Xiao-Yan et. al.
Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis.
score: 0.99581518, Antimicrobial agents and chemotherapy, 2010, Ando, Hiroki et. al.
Inhibition of herpes simplex virus type 1 infection by cationic beta-peptides.
score: 0.99578937, Antimicrobial agents and chemotherapy, 2008, Akkarawongsa, Radeekorn et. al.
Predicting potential miRNA target sites within gene promoters
score: 0.99577734, Bioorganic & Medicinal Chemistry Letters, 2009, Younger, Scott T.; Pertsemlidis, Alexander; Corey, David R.
New groups of antimycobacterial agents: 6-chloro-3-phenyl-4-thioxo-2 H -1,3-benzoxazine-2(3 H )-ones and 6-chloro-3-phenyl-2 H -1,3-benzoxazine-2,4(3 H )-dithiones
score: 0.99574354, European Journal of Medicinal Chemistry, 2000, Waisser, Karel et. al.
First report of Salmonella isolates with the DHA-1 AmpC beta-lactamase in the United Kingdom.
score: 0.99573718, Antimicrobial agents and chemotherapy, 2004, Liebana, E et. al.
Vancomycin-resistant Enterococcus faecium strains with highly similar pulsed-field gel electrophoresis patterns containing similar Tn1546-like elements isolated from a hospitalized patient and pigs in Denmark.
score: 0.99573718, Antimicrobial agents and chemotherapy, 1999, Jensen, L B; Hammerum, A M; Poulsen, R L; Westh, H
Increasing resistance of Brucellae to co-trimoxazole.
score: 0.99573718, Antimicrobial agents and chemotherapy, 1999, Kinsara, A; Al-Mowallad, A; Osoba, A O
Trimethoprim-sulfamethoxazole prophylaxis and antibiotic nonsusceptibility in invasive pneumococcal disease.
score: 0.99573718, Antimicrobial agents and chemotherapy, 2012, Soeters, Heidi M et. al.
Heterogeneity of genotype-phenotype correlation among macrolide-resistant Streptococcus agalactiae isolates.
score: 0.99573718, Antimicrobial agents and chemotherapy, 2005, von Both, Ulrich et. al.
Antibiotic resistance in urinary isolates of Escherichia coli from college women with urinary tract infections.
score: 0.99573718, Antimicrobial agents and chemotherapy, 2009, Olson, Ronald P; Harrell, Lizzie J; Kaye, Keith S
Demonstration of conjugative transposon (Tn5397)-mediated horizontal gene transfer between Clostridium difficile and Enterococcus faecalis.
score: 0.99573718, Antimicrobial agents and chemotherapy, 2010, Jasni, Azmiza S et. al.
Virulence factors of Escherichia coli isolates that produce CTX-M-type extended-spectrum beta-lactamases.
score: 0.99573718, Antimicrobial agents and chemotherapy, 2005, Pitout, Johann D D et. al.
Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae.
score: 0.99573718, Antimicrobial agents and chemotherapy, 2005, Trzciński, Krzysztof et. al.
RNA-RNA interactions between oligonucleotide substrates for aminoacylation
score: 0.99571296, Bioorganic & Medicinal Chemistry, 1997, Henderson, Barry S.; Schimmel, Paul
Pharmacokinetics of ampicillin and sulbactam in pediatric patients.
score: 0.99570004, Antimicrobial agents and chemotherapy, 1999, Nahata, M C; Vashi, V I; Swanson, R N; Messig, M A; Chung, M
Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1
score: 0.99568582, Bioorganic & Medicinal Chemistry, 2012, Johnston, Jonathan B. et. al.
Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1
score: 0.99568582, Bioorganic & Medicinal Chemistry, 2012, Johnston, Jonathan B. et. al.
Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1
score: 0.99568582, Bioorganic & Medicinal Chemistry, 2012, Johnston, Jonathan B. et. al.
Melatonin attenuates colistin-induced nephrotoxicity in rats.
score: 0.99558265, Antimicrobial agents and chemotherapy, 2011, Yousef, Jumana M et. al.
Effect of 3-hydroxyphthaloyl-beta-lactoglobulin on vaginal transmission of simian immunodeficiency virus in rhesus monkeys.
score: 0.99558057, Antimicrobial agents and chemotherapy, 1999, Wyand, M S; Manson, K H; Miller, C J; Neurath, A R
Micafungin concentrations in the plasma and burn eschar of severely burned patients.
score: 0.99555806, Antimicrobial agents and chemotherapy, 2012, Sasaki, Junichi et. al.
Transfer of vancomycin resistance transposon Tn1549 from Clostridium symbiosum to Enterococcus spp. in the gut of gnotobiotic mice.
score: 0.99553456, Antimicrobial agents and chemotherapy, 2006, Launay, Aline et. al.
Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria.
score: 0.9955345, Antimicrobial agents and chemotherapy, 2006, Kazimierczak, Katarzyna A; Flint, Harry J; Scott, Karen P
The trailing end point phenotype in antifungal susceptibility testing is pH dependent.
score: 0.99546788, Antimicrobial agents and chemotherapy, 1999, Marr, K A; Rustad, T R; Rex, J H; White, T C
An o-nitrobenzyl scaffold for peptide ligation: synthesis and applications
score: 0.99537631, Bioorganic & Medicinal Chemistry, 2004, Marinzi, Chiara et. al.
New benzo[ g]isoquinoline-5,10-diones and dihydrothieno [2,3- b]naphtho-4,9-dione derivatives
score: 0.99537372, Bioorganic & Medicinal Chemistry, 2003, Gomez-Monterrey, Isabel et. al.
Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA
score: 0.99536008, Bioorganic & Medicinal Chemistry, 2005, Chen, Wen-Hua et. al.
Microbiologic and immunologic evaluation of a single high dose of azithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia.
score: 0.99528755, Antimicrobial agents and chemotherapy, 2005, Ríos, Ana María et. al.
FLAG-tag selective covalent protein labeling via a binding-induced acyl-transfer reaction
score: 0.99526784, Bioorganic & Medicinal Chemistry Letters, 2009, Nonaka, Hiroshi et. al.
Oseltamivir pharmacokinetics and clinical experience in neonates and infants during an outbreak of H1N1 influenza A virus infection in a neonatal intensive care unit.
score: 0.99525959, Antimicrobial agents and chemotherapy, 2012, Standing, Joseph F et. al.
Homology modelling and active-site-mutagenesis study of the catalytic domain of the pneumococcal phosphorylcholine esterase
score: 0.99509209, Bioorganic & Medicinal Chemistry, 2005, Campillo, Nuria Eugenia et. al.
Design and synthesis of photolabile caged cytokinin
score: 0.9950689, Bioorganic & Medicinal Chemistry Letters, 2012, Hayashi, Ken-ichiro et. al.
Utilization of omeprazole to augment subtherapeutic voriconazole concentrations for treatment of Aspergillus infections.
score: 0.99503192, Antimicrobial agents and chemotherapy, 2012, Boyd, Natalie K et. al.
Interaction between grapefruit juice and praziquantel in humans.
score: 0.9950191, Antimicrobial agents and chemotherapy, 2002, Castro, Nelly et. al.
Synthesis of a triply phosphorylated pentapeptide from human τ-protein
score: 0.99501675, Bioorganic & Medicinal Chemistry, 2000, Kuder, Norman et. al.
Tularemia and once-daily gentamicin.
score: 0.99488156, Antimicrobial agents and chemotherapy, 2006, Hassoun, Ali; Spera, Richard; Dunkel, John
Insufficient evidence that extended-spectrum cephalosporins effectively prevent metastatic infections related to Klebsiella pneumoniae-caused liver abscess.
score: 0.99485711, Antimicrobial agents and chemotherapy, 2004, Lee, Susan Shin-Jung et. al.
Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis.
score: 0.99477961, Antimicrobial agents and chemotherapy, 1998, Williams, D L et. al.
Hydrophobic benzoic acids as inhibitors of influenza neuraminidase
score: 0.99476707, Bioorganic & Medicinal Chemistry, 1999, Atigadda, Venkatram R. et. al.
Streptococcus pyogenes pharyngeal isolates with reduced susceptibility to ciprofloxacin in Spain: mechanisms of resistance and clonal diversity.
score: 0.99475118, Antimicrobial agents and chemotherapy, 2005, Albertí, Sebastián et. al.
Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.
score: 0.99470915, Antimicrobial agents and chemotherapy, 2012, Arab-Alameddine, Mona et. al.
Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.
score: 0.99467818, Antimicrobial agents and chemotherapy, 2010, Witkowski, Benoit et. al.
Effect of subinhibitory concentrations of antibiotics on intrachromosomal homologous recombination in Escherichia coli.
score: 0.99463992, Antimicrobial agents and chemotherapy, 2009, López, Elena; Blázquez, Jesús
Structural effects on the reactivity 1,4-dihydropyridines with alkylperoxyl radicals and ABTS radical cation
score: 0.99463784, Bioorganic & Medicinal Chemistry, 2004, Yáñez, C et. al.
Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis.
score: 0.99463331, Antimicrobial agents and chemotherapy, 2009, Takazono, Takahiro et. al.
SGI2, a relative of Salmonella genomic island SGI1 with an independent origin.
score: 0.99462083, Antimicrobial agents and chemotherapy, 2008, Levings, Renee S; Djordjevic, Steven P; Hall, Ruth M
Synthesis of octadecylamine-retinoic acid conjugate for enhanced cytotoxic effects of 5-FU using LDL targeted nanostructured lipid carriers
score: 0.99459067, European Journal of Medicinal Chemistry, 2012, Varshosaz, Jaleh et. al.
Comparison of visual and spectrophotometric methods of broth microdilution MIC end point determination and evaluation of a sterol quantitation method for in vitro susceptibility testing of fluconazole and itraconazole against trailing and nontrailing Candida isolates.
score: 0.99456873, Antimicrobial agents and chemotherapy, 2002, Arthington-Skaggs, Beth A et. al.
Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure.
score: 0.99444707, Antimicrobial agents and chemotherapy, 2009, Fransen, Signe et. al.
Treatment of experimental anthrax with recombinant capsule depolymerase.
score: 0.99436012, Antimicrobial agents and chemotherapy, 2008, Scorpio, Angelo et. al.
A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron.
score: 0.99426528, Antimicrobial agents and chemotherapy, 2001, Miyamae, S et. al.
Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital.
score: 0.99418803, Antimicrobial agents and chemotherapy, 2004, Leflon-Guibout, Véronique et. al.
Tn6001, a transposon-like element containing the blaVIM-3-harboring integron In450.
score: 0.99418803, Antimicrobial agents and chemotherapy, 2007, Tseng, Sung-Pin et. al.
Molecular epidemiology of the SRL pathogenicity island.
score: 0.99408351, Antimicrobial agents and chemotherapy, 2003, Turner, Sally A et. al.
Ability of Candida albicans mutants to induce Staphylococcus aureus vancomycin resistance during polymicrobial biofilm formation.
score: 0.99405928, Antimicrobial agents and chemotherapy, 2010, Harriott, Melphine M; Noverr, Mairi C
Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance.
score: 0.99394177, Antimicrobial agents and chemotherapy, 2002, Angiolella, Letizia et. al.
New antimicrobial agents approved by the U.S. Food and Drug Administration in 2010 and 2011 and new indications for previously approved agents(a).
score: 0.99387243, Antimicrobial agents and chemotherapy, 2011,
New antimicrobial agents approved by the U.S. Food and Drug Administration in 2006 and new indications for previously approved agents.
score: 0.99387243, Antimicrobial agents and chemotherapy, 2007,
New antimicrobial agents approved by the US Food and Drug Administration in 2003 and new indications for previously approved agents.
score: 0.99387243, Antimicrobial agents and chemotherapy, 2004,
New antimicrobial agents approved by the U.S. Food and Drug Administration in 2005 and new indications for previously approved agents.
score: 0.99387243, Antimicrobial agents and chemotherapy, 2006,
New antimicrobial agents approved by the U.S. Food and Drug Administration in 2002 and new indications for previously approved agents.
score: 0.99387243, Antimicrobial agents and chemotherapy, 2003,
New antimicrobial agents approved by U.S Food and Drug Administration in 2000 and new indication for previously approved agents.
score: 0.99387243, Antimicrobial agents and chemotherapy, 2001,
New antimicrobial agents approved by the U.S. Food and Drug Administration in 1998 and new indications for previously approved agents.
score: 0.99387243, Antimicrobial agents and chemotherapy, 1999,
Activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.
score: 0.99374276, Antimicrobial agents and chemotherapy, 2003, Goswick, Shannon M; Brenner, George M
Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2′-butylamino)-4 H- and 3-(3′-methyl-2′-butylamino)-4 H-pyrido[4,3- e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
score: 0.99370341, Bioorganic & Medicinal Chemistry, 1999, Khelili, Smail et. al.
Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients.
score: 0.99363433, Antimicrobial agents and chemotherapy, 2005, Pruvost, Alain et. al.
Immunomodulation of pneumococcal pulmonary infection with N(G)-monomethyl-L-arginine.
score: 0.99358925, Antimicrobial agents and chemotherapy, 1999, Bergeron, Y et. al.
Effect of fasting on temporal variation in the nephrotoxicity of amphotericin B in rats.
score: 0.99355825, Antimicrobial agents and chemotherapy, 1999, LeBrun, M et. al.
Synthesis and properties of 3′-amino-2′,4′-BNA, a bridged nucleic acid with a N3′→P5′ phosphoramidate linkage
score: 0.99351172, Bioorganic & Medicinal Chemistry, 2008, Obika, Satoshi et. al.
Aminoglycoside 6'-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii.
score: 0.99350447, Antimicrobial agents and chemotherapy, 1998, Casin, I et. al.
QSAR study on tadpole narcosis using PI index: a case of heterogenous set of compounds
score: 0.99348259, Bioorganic & Medicinal Chemistry, 2004, Jaiswal, Mona; Khadikar, Padmakar
Oxidative stress induction of the MexXY multidrug efflux genes and promotion of aminoglycoside resistance development in Pseudomonas aeruginosa.
score: 0.9934807, Antimicrobial agents and chemotherapy, 2011, Fraud, Sebastien; Poole, Keith
In vitro model of colonization resistance by the enteric microbiota: effects of antimicrobial agents used in food-producing animals.
score: 0.99347451, Antimicrobial agents and chemotherapy, 2008, Wagner, R Doug; Johnson, Shemedia J; Cerniglia, Carl E
Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities
score: 0.993415, Bioorganic & Medicinal Chemistry, 2005, Saladino, Raffaele et. al.
Impact of flavophospholipol and vancomycin on conjugational transfer of vancomycin resistance plasmids.
score: 0.99338165, Antimicrobial agents and chemotherapy, 2000, Riedl, S; Ohlsen, K; Werner, G; Witte, W; Hacker, J
Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes.
score: 0.99335412, Antimicrobial agents and chemotherapy, 2006, Geiman, Deborah E et. al.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
score: 0.99332829, Antimicrobial agents and chemotherapy, 2005, Villa, Laura; Carattoli, Alessandra
Hazard ratio in clinical trials.
score: 0.99332807, Antimicrobial agents and chemotherapy, 2004, Spruance, Spotswood L et. al.
Successful treatment of fulminant hepatitis C by therapy with alpha interferon and ribavirin.
score: 0.99332807, Antimicrobial agents and chemotherapy, 2005, Yu, Ming-Lung et. al.
Human herpesvirus 8 DNA load in leukocytes of human immunodeficiency virus-infected subjects: correlation with the presence of Kaposi's sarcoma and response to anticytomegalovirus therapy.
score: 0.99332807, Antimicrobial agents and chemotherapy, 1999, Boivin, G et. al.
A multireceptorial binding reinvestigation on an extended class of σ ligands: N-[ω-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards σ 1 and EBP sites
score: 0.99324322, Bioorganic & Medicinal Chemistry, 2001, Berardi, Francesco et. al.
Lack of interaction of fluoroquinolones with lipopolysaccharides.
score: 0.99323678, Antimicrobial agents and chemotherapy, 2002, Lindner, B; Wiese, A; Brandenburg, K; Seydel, U; Dalhoff, A
Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice
score: 0.99322266, European Journal of Medicinal Chemistry, 2012, Lee, Yean-Jang et. al.
Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice
score: 0.99322266, European Journal of Medicinal Chemistry, 2012, Lee, Yean-Jang et. al.
Randomized double-blind study comparing 3- and 6-day regimens of azithromycin with a 10-day amoxicillin-clavulanate regimen for treatment of acute bacterial sinusitis.
score: 0.99317036, Antimicrobial agents and chemotherapy, 2003, Henry, Dan C et. al.
Activity of human beta-defensin 3 alone or combined with other antimicrobial agents against oral bacteria.
score: 0.99314955, Antimicrobial agents and chemotherapy, 2003, Maisetta, Giuseppantonio et. al.
Binding and permeabilization of lipid bilayers by natural and synthetic 3-alkylpyridinium polymers
score: 0.99313665, Bioorganic & Medicinal Chemistry, 2012, Grandič, Marjana et. al.
Delivery of granulocyte-macrophage colony-stimulating factor in bioadhesive hydrogel stimulates migration of dendritic cells in models of human papillomavirus-associated (pre)neoplastic epithelial lesions.
score: 0.99307306, Antimicrobial agents and chemotherapy, 2004, Hubert, Pascale et. al.
Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase.
score: 0.99306633, Antimicrobial agents and chemotherapy, 2010, Chevillotte, Meike et. al.
Acid-sensitive polyethylene glycol conjugates of doxorubicin: preparation, in vitro efficacy and intracellular distribution
score: 0.99302534, Bioorganic & Medicinal Chemistry, 1999, Rodrigues, Paula C.A. et. al.
Synthesis and cytotoxicity evaluation of 2-amino- and 2-hydroxy-3-ethoxycarbonyl- N-substituted-benzo[ f]indole-4,9-dione derivatives
score: 0.99301777, Bioorganic & Medicinal Chemistry, 2003, Lee, Hyun-Jung; Suh, Myung-Eun; Lee, Chong-Ock
Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection.
score: 0.99299693, Antimicrobial agents and chemotherapy, 2008, Mookerjee Basu, Jayati et. al.
Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants.
score: 0.99298186, Antimicrobial agents and chemotherapy, 2003, Kumano, Miyuki et. al.
Intravenous infusion of cereport increases uptake and efficacy of acyclovir in herpes simplex virus-infected rat brains.
score: 0.99287984, Antimicrobial agents and chemotherapy, 2001, Bidanset, D J et. al.
Disruption of the Candida albicans CYB5 gene results in increased azole sensitivity.
score: 0.9928657, Antimicrobial agents and chemotherapy, 2004, Rogers, K M et. al.
Should moxifloxacin be used for the treatment of extensively drug-resistant tuberculosis? An answer from a murine model.
score: 0.99284254, Antimicrobial agents and chemotherapy, 2010, Poissy, Julien et. al.
A highly efficient biomimetic aromatization of Hantzsch-1,4-dihydropyridines with t-butylhydroperoxide, catalysed by iron(III) phthalocyanine chloride
score: 0.99280216, Bioorganic & Medicinal Chemistry, 2008, Filipan-Litvić, Mirela; Litvić, Mladen; Vinković, Vladimir
Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin
score: 0.9927592, Bioorganic & Medicinal Chemistry, 2002, Chui, Helen M.-P et. al.
Tumor Cell-Specific Prodrugs Using Arsonic Acid-Presenting Iron Oxide Nanoparticles with High Sensitivity
score: 0.99266305, Bioorganic & Medicinal Chemistry, 2012, Minehara, Hiroki et. al.
CD4(+)-T-Cell-mediated resistance to systemic murine candidiasis induced by a membrane fraction of Candida albicans.
score: 0.99264746, Antimicrobial agents and chemotherapy, 2000, Mizutani, S et. al.
Pharmacokinetics of piperacillin-tazobactam in anuric intensive care patients during continuous venovenous hemodialysis.
score: 0.99254914, Antimicrobial agents and chemotherapy, 2002, Mueller, Silke C et. al.
Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
score: 0.99251784, Antimicrobial agents and chemotherapy, 2009, Marquez, Béatrice et. al.
Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America.
score: 0.99245254, Antimicrobial agents and chemotherapy, 2000, Tait-Kamradt, A et. al.
Randomized Controlled Trial of the Safety and Efficacy of Daptomycin versus Standard-of-Care Therapy for Management of Patients with Osteomyelitis Associated with Prosthetic Devices Undergoing Two-Stage Revision Arthroplasty.
score: 0.99239198, Antimicrobial agents and chemotherapy, 2012, Byren, Ivor et. al.
Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine.
score: 0.99230391, Antimicrobial agents and chemotherapy, 2012, Zvada, Simbarashe P et. al.
Novel polycyclic ‘cage’-1,2-diamines as potential anti-tuberculosis agents
score: 0.99230222, European Journal of Medicinal Chemistry, 2012, Onajole, Oluseye K. et. al.
Discovery of novel inhibitors of LEDGF/p75-IN protein–protein interactions
score: 0.9922858, Bioorganic & Medicinal Chemistry, 2013, Sanchez, Tino Wilson et. al.
Lack of pharmacokinetic interaction between the oral anti-influenza prodrug oseltamivir and aspirin.
score: 0.99225165, Antimicrobial agents and chemotherapy, 2002, Oo, Charles et. al.
Experimental phage therapy in treating Klebsiella pneumoniae-mediated liver abscesses and bacteremia in mice.
score: 0.99220448, Antimicrobial agents and chemotherapy, 2011, Hung, Chih-Hsin et. al.
Plasmid-mediated quinolone resistance in isolates obtained in german intensive care units.
score: 0.99208512, Antimicrobial agents and chemotherapy, 2005, Jonas, Daniel et. al.
Investigation of the interaction between amodiaquine and human serum albumin by fluorescence spectroscopy and molecular modeling
score: 0.99202775, European Journal of Medicinal Chemistry, 2012, Samari, Fayezeh et. al.
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.
score: 0.99202448, Nature biotechnology, 2005, Card, Graeme L et. al.
Novel lamivudine resistance.
score: 0.99199529, Antimicrobial agents and chemotherapy, 2007, Schildgen, Oliver
Inhaled nitric oxide treatment of patients with pulmonary tuberculosis evidenced by positive sputum smears.
score: 0.99199306, Antimicrobial agents and chemotherapy, 2005, Long, Richard et. al.
Biomimetic ligands for transition metals: catechol-containing peptides
score: 0.99198792, Bioorganic & Medicinal Chemistry Letters, 2000, Ashraf, Muhammed A; Jones, Keith; Handa, Sheetal
Solution Chemistry and DNA Binding Properties of MEN 10755, A Novel Disaccharide Analogue of Doxorubicin
score: 0.9919151, Bioorganic & Medicinal Chemistry, 2001, Messori, Luigi et. al.
Pharmacokinetic Interaction between amprenavir and rifabutin or rifampin in healthy males.
score: 0.99186311, Antimicrobial agents and chemotherapy, 2001, Polk, R E et. al.
Combination therapy using sodium antimony gluconate in stearylamine-bearing liposomes against established and chronic Leishmania donovani infection in BALB/c Mice.
score: 0.99175791, Antimicrobial agents and chemotherapy, 2004, Pal, Swati; Ravindran, Rajesh; Ali, Nahid
Amphotericin B resistance and membrane fluidity in Kluyveromyces lactis strains.
score: 0.99168424, Antimicrobial agents and chemotherapy, 2000, Younsi, M; Ramanandraibe, E; Bonaly, R; Donner, M; Coulon, J
Activation of the 2'-N-acetyltransferase gene [aac(2')-Ia] in Providencia stuartii by an interaction of AarP with the promoter region.
score: 0.99162268, Antimicrobial agents and chemotherapy, 1999, Macinga, D R; Paradise, M R; Parojcic, M M; Rather, P N
Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones
score: 0.99158937, Bioorganic & Medicinal Chemistry, 2012, Brackman, Gilles et. al.
Concentrations of pefloxacin in plasma and tissue after administration as surgical prophylaxis.
score: 0.99153317, Antimicrobial agents and chemotherapy, 1998, Jacoberger, B et. al.
Enhanced antiscrapie effect using combination drug treatment.
score: 0.9914641, Antimicrobial agents and chemotherapy, 2006, Kocisko, David A et. al.
Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom.
score: 0.99140344, Antimicrobial agents and chemotherapy, 2003, Miller, Robert F et. al.
Synthesis and antitumor activity of some indeno[1,2- b]quinoline-based bis carboxamides
score: 0.99134866, Bioorganic & Medicinal Chemistry, 2000, Deady, Leslie W et. al.
Adenosiland: Walking through adenosine receptors landscape
score: 0.99126122, European Journal of Medicinal Chemistry, 2012, Floris, Matteo et. al.
Adenosiland: Walking through adenosine receptors landscape
score: 0.99126122, European Journal of Medicinal Chemistry, 2012, Floris, Matteo et. al.
Adenosiland: Walking through adenosine receptors landscape
score: 0.99126122, European Journal of Medicinal Chemistry, 2012, Floris, Matteo et. al.
A new approach for early assessment of the epileptogenic potential of quinolones.
score: 0.99116967, Antimicrobial agents and chemotherapy, 1998, Delon, A; Pariat, C; Courtois, P; Bouquet, S; Couet, W
Synthesis of Substituted Indeno[1,2- b]quinoline-6-carboxamides, [1]benzothieno[3,2- b]quinoline-4-carboxamides and 10 H-quindoline-4-carboxamides: Evaluation of Structure–Activity Relationships for Cytotoxicity
score: 0.99100296, Bioorganic & Medicinal Chemistry, 2000, Chen, Junjie et. al.
In vivo impact of Met221 substitution in GOB metallo-β-lactamase.
score: 0.99097037, Antimicrobial agents and chemotherapy, 2012, Morán-Barrio, Jorgelina et. al.
Steady-state plasma pharmacokinetics of oral voriconazole in obese adults.
score: 0.99090054, Antimicrobial agents and chemotherapy, 2011, Pai, Manjunath P; Lodise, Thomas P
Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA.
score: 0.99087004, Antimicrobial agents and chemotherapy, 2000, Galimand, M; Gerbaud, G; Courvalin, P
Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease.
score: 0.9908559, Antimicrobial agents and chemotherapy, 2012, Kozísek, Milan et. al.
Thiazole Orange derivatives: Synthesis, fluorescence properties, and labeling cancer cells
score: 0.99084009, Bioorganic & Medicinal Chemistry, 2009, Fei, Xuening et. al.
Protein microarray using α-amino acids as metal tags on chips
score: 0.9906961, Bioorganic & Medicinal Chemistry Letters, 2005, Sinchaikul, Supachok et. al.
SMILES-based optimal descriptors: QSAR modeling of carcinogenicity by balance of correlations with ideal slopes
score: 0.99068645, European Journal of Medicinal Chemistry, 2010, Toropov, A.A.; Toropova, A.P.; Benfenati, E.
Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis
score: 0.99063504, Bioorganic & Medicinal Chemistry, 2003, Aoki, Shunji et. al.
New cyanine dyes as base surrogates in PNA: Forced intercalation probes (FIT-probes) for homogeneous SNP detection
score: 0.99061176, Bioorganic & Medicinal Chemistry, 2008, Bethge, Lucas; Jarikote, Dilip Venkatrao; Seitz, Oliver
Molecular Orbital Calculation for the Model Compounds of Kainoid Amino Acids, Agonists of Excitatory Amino Acid Receptors. Does the Kainoid C4-Substituent Directly Interact with the Receptors?
score: 0.9905981, Bioorganic & Medicinal Chemistry, 2002, Hashimoto, Kimiko et. al.
Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa.
score: 0.99059253, Antimicrobial agents and chemotherapy, 2002, Lepper, Philipp M et. al.
Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT 1A serotonin receptor ligands
score: 0.9905727, Bioorganic & Medicinal Chemistry, 2000, Caliendo, Giuseppe et. al.
Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a hamster model.
score: 0.99050289, Antimicrobial agents and chemotherapy, 2007, Morrey, John D et. al.
Real-time PCR and melting curve analysis for reliable and rapid detection of SHV extended-spectrum beta-lactamases.
score: 0.99048754, Antimicrobial agents and chemotherapy, 2001, Randegger, C C; Hächler, H
Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patients.
score: 0.99047248, Antimicrobial agents and chemotherapy, 2005, Fish, Douglas N; Teitelbaum, Isaac; Abraham, Edward
Comparisons between antimicrobial pharmacodynamic indices and bacterial killing as described by using the Zhi model.
score: 0.99047058, Antimicrobial agents and chemotherapy, 1998, Corvaisier, S et. al.
The large mechanosensitive channel MscL determines bacterial susceptibility to the bacteriocin sublancin 168.
score: 0.99046217, Antimicrobial agents and chemotherapy, 2009, Kouwen, Thijs R H M et. al.
Human immunoglobulin G recognizing fibrinogen-binding surface proteins is protective against both Staphylococcus aureus and Staphylococcus epidermidis infections in vivo.
score: 0.99023443, Antimicrobial agents and chemotherapy, 2006, Vernachio, John H et. al.
In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes.
score: 0.99003322, Antimicrobial agents and chemotherapy, 2002, Sun, Qiu N et. al.
Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC.
score: 0.98998395, Antimicrobial agents and chemotherapy, 2006, Ricci, Vito et. al.
Correlation of fluconazole MICs with clinical outcome in cryptococcal infection.
score: 0.98993271, Antimicrobial agents and chemotherapy, 2000, Aller, A I et. al.
Clustered ergot alkaloids modulate cell-mediated cytotoxicity
score: 0.98992558, Bioorganic & Medicinal Chemistry, 2002, Křen, Vladimı́r et. al.
Assessing the efficacy of cidofovir against herpesvirus-induced genital lesions in goats using different therapeutic regimens.
score: 0.98990081, Antimicrobial agents and chemotherapy, 2008, Tempesta, M et. al.
Triazene drug metabolites. Part 17: synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes
score: 0.98989066, Bioorganic & Medicinal Chemistry, 2000, Carvalho, Emı́lia et. al.
Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds
score: 0.98986954, Bioorganic & Medicinal Chemistry, 2008, Wängler, C. et. al.
1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine
score: 0.98984576, Bioorganic & Medicinal Chemistry, 1996, Chiarini, A. et. al.
Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay.
score: 0.98974626, Antimicrobial agents and chemotherapy, 2001, Okamoto, K; Gotoh, N; Nishino, T
Systemic expression of cytokine production in patients with severe pneumococcal pneumonia: effects of treatment with a beta-lactam versus a fluoroquinolone.
score: 0.98969523, Antimicrobial agents and chemotherapy, 2008, Calbo, Esther et. al.
Intracutaneous distributions of fluconazole, itraconazole, and griseofulvin in Guinea pigs and binding to human stratum corneum.
score: 0.98956972, Antimicrobial agents and chemotherapy, 2004, Sobue, Satoshi; Sekiguchi, Kaneo; Nabeshima, Toshitaka
Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis.
score: 0.98955263, Antimicrobial agents and chemotherapy, 2003, Zeitlinger, M A et. al.
Characterization of mupirocin-resistant Staphylococcus aureus from different geographic areas.
score: 0.98954642, Antimicrobial agents and chemotherapy, 1998, Ramsey, M A et. al.
aac(6')-Ib-cr genotyping by simultaneous high-resolution melting analyses of an unlabeled probe and full-length amplicon.
score: 0.98943844, Antimicrobial agents and chemotherapy, 2010, Bell, Jan M; Turnidge, John D; Andersson, Patiyan
A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor
score: 0.98943055, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Min et. al.
Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophages.
score: 0.98942083, Antimicrobial agents and chemotherapy, 2004, Jorajuria, Sylvie et. al.
Hairpin-shaped tetranuclear palladium(II) complex: Synthesis, crystal structure, DNA binding and cytotoxicity activity studies
score: 0.98934192, European Journal of Medicinal Chemistry, 2010, Gao, En-Jun; Wang, Ke-Hua; Zhu, Ming-Chang; Liu, Lei
Hairpin-shaped tetranuclear palladium(II) complex: Synthesis, crystal structure, DNA binding and cytotoxicity activity studies
score: 0.98934192, European Journal of Medicinal Chemistry, 2010, Gao, En-Jun; Wang, Ke-Hua; Zhu, Ming-Chang; Liu, Lei
Nitric oxide-induced oxidation of α-tocopherol
score: 0.98932313, Bioorganic & Medicinal Chemistry, 1996, d'Ischia, Marco; Novellino, Luisa
In vivo efficacy of telithromycin (HMR3647) against Streptococcus pneumoniae and Haemophilus influenzae.
score: 0.98928437, Antimicrobial agents and chemotherapy, 2001, Okamoto, H; Miyazaki, S; Tateda, K; Ishii, Y; Yamaguchi, K
The acetates of p-nitrophenyl α- l-arabinofuranoside—Regioselective preparation by action of lipases
score: 0.98927817, Bioorganic & Medicinal Chemistry, 2006, Mastihubová, Mária; Szemesová, Jana; Biely, Peter
Residual attributable mortality, a new concept for understanding the value of antibiotics in treating life-threatening acute infections.
score: 0.98926524, Antimicrobial agents and chemotherapy, 2010, Wenzel, Richard P; Gennings, Chris
The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.
score: 0.98916062, Antimicrobial agents and chemotherapy, 2004, Vanden Bossche, Hugo et. al.
Bacteremia due to Bacteroides fragilis group: distribution of species, beta-lactamase production, and antimicrobial susceptibility patterns.
score: 0.98912934, Antimicrobial agents and chemotherapy, 2003, Aldridge, Kenneth E et. al.
Transferred nuclear Overhauser effect study of macrolide–ribosome interactions: correlation between antibiotic activities and bound conformations
score: 0.9890636, Bioorganic & Medicinal Chemistry, 1998, Bertho, Gildas et. al.
Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
score: 0.98903176, Antimicrobial agents and chemotherapy, 2004, Johnston, Elizabeth et. al.
Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis.
score: 0.98899088, Antimicrobial agents and chemotherapy, 2005, Gavaldà, Joan et. al.
Short-term therapy with luliconazole, a novel topical antifungal imidazole, in guinea pig models of tinea corporis and tinea pedis.
score: 0.98893837, Antimicrobial agents and chemotherapy, 2012, Koga, Hiroyasu et. al.
reversible modulation of human factor xa activity with phosphonate esters: media effects
score: 0.98888723, Bioorganic & Medicinal Chemistry, 2000, Enyedy, Edith J.; Kovach, Ildiko M.
Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.
score: 0.98883604, Antimicrobial agents and chemotherapy, 2005, Zaragoza, Oscar et. al.
A novel thrombin binding aptamer containing a G-LNA residue
score: 0.98882958, Bioorganic & Medicinal Chemistry, 2007, Virno, Ada et. al.
1-[2-Hydroxy-3-octadecan-1′-oate]propyl-2″,2″,5″,5″-tetramethyl Pyrolidine- N-oxyl-3″-carboxylate as a potential spin probe for membrane structure studies
score: 0.98881118, Bioorganic & Medicinal Chemistry, 1999, Katoch, Rita; Trivedi, Girish K.; Phadke, Ratna S.
Design of proteins using rigid organic macrocycles as scaffolds
score: 0.98870984, Bioorganic & Medicinal Chemistry, 1999, Causton, Ashley S.; Sherman, John C.
Non-covalent modification of the heme-pocket of apomyoglobin by a 1,10-phenanthroline derivative
score: 0.98868445, Bioorganic & Medicinal Chemistry Letters, 2006, Hitomi, Yutaka et. al.
Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand
score: 0.9886804, European Journal of Medicinal Chemistry, 2009, Lawrence Arockiasamy, D. et. al.
Synthesis of novel 6-amido-6-deoxy- l-galactose derivatives as sialyl Lewis X mimetics
score: 0.98867587, Bioorganic & Medicinal Chemistry, 1997, Cappi, Michael W. et. al.
5′-Linked lipid-oligodeoxyribonucleotide derivatives as inhibitors of human immunodeficiency virus replication
score: 0.98865635, Bioorganic & Medicinal Chemistry, 1996, Kim, Sang-Gug et. al.
Characterization of UC781-tenofovir combination gel products for HIV-1 infection prevention in an ex vivo ectocervical model.
score: 0.98865442, Antimicrobial agents and chemotherapy, 2012, Cost, Marilyn et. al.
Design, synthesis and evaluation of transition-state analogue inhibitors of Escherichia coli γ-glutamylcysteine synthetase
score: 0.98854678, Bioorganic & Medicinal Chemistry, 1998, Tokutake, Nobuya et. al.
Suppression of posttreatment recurrence of experimental visceral Leishmaniasis in T-cell-deficient mice by oral miltefosine.
score: 0.98852782, Antimicrobial agents and chemotherapy, 2000, Murray, H W
Seven novel variants of the staphylococcal chromosomal cassette mec in methicillin-resistant Staphylococcus aureus isolates from Ireland.
score: 0.98847301, Antimicrobial agents and chemotherapy, 2005, Shore, Anna et. al.
Genotypic resistance analysis of the virological response to fosamprenavir-ritonavir in protease inhibitor-experienced patients in CONTEXT and TRIAD clinical trials.
score: 0.98845586, Antimicrobial agents and chemotherapy, 2008, Marcelin, Anne-Geneviève et. al.
Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.
score: 0.98833642, Antimicrobial agents and chemotherapy, 2005, Komp Lindgren, Patricia et. al.
Synthesis of Tc-99m labeled 1,2,3-triazole-4-yl c-met binding peptide as a potential c-met receptor kinase positive tumor imaging agent
score: 0.98826831, Bioorganic & Medicinal Chemistry Letters, 2010, Kim, Eun-Mi et. al.
The marvels of biosynthesis: Tracking nature's pathways
score: 0.98824727, Bioorganic & Medicinal Chemistry, 1996, Battersby, Alan R.
Multidrug resistant Mycobacterium leprae from patients with leprosy.
score: 0.9881559, Antimicrobial agents and chemotherapy, 2001, Maeda, S et. al.
Relevance of molecular weight of chitosan- N-2-hydroxypropyl trimethyl ammonium chloride and their antioxidant activities
score: 0.98803746, European Journal of Medicinal Chemistry, 2008, Xing, Ronge et. al.
Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.
score: 0.98802402, Antimicrobial agents and chemotherapy, 2004, Jensen, S E et. al.
Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation
score: 0.98802144, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L.; Garbaccio, Robert M.
New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.
score: 0.98793438, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, López-Ramos, Miriam et. al.
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 9: Comparison of acetoxy 4-methylcoumarins and other polyphenolic acetates reveal the specificity to acetoxy drug: protein transacetylase for pyran carbonyl group in proximity to the oxygen heteroatom
score: 0.98792255, Bioorganic & Medicinal Chemistry, 2002, Singh, Ishwar et. al.
Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC.
score: 0.98787837, Antimicrobial agents and chemotherapy, 2004, Ito, Teruyo et. al.
Early- and late-onset pneumonia: is this still a useful classification?
score: 0.98783976, Antimicrobial agents and chemotherapy, 2009, Gastmeier, Petra et. al.
Use of Phenyl 2-α-Selenoglycosides of N-Acetylneuraminic Acid as a Glycosyl Donor for the Glycosylation Reactions
score: 0.98782345, Bioorganic & Medicinal Chemistry Letters, 2002, Ikeda, Kiyoshi et. al.
The magnitude of the association between fluoroquinolone use and quinolone-resistant Escherichia coli and Klebsiella pneumoniae may be lower than previously reported.
score: 0.98773034, Antimicrobial agents and chemotherapy, 2004, Bolon, Maureen K et. al.
Failure of short-course ceftriaxone chemotherapy for multidrug-resistant typhoid fever in children: a randomized controlled trial in Pakistan.
score: 0.98771046, Antimicrobial agents and chemotherapy, 2000, Bhutta, Z A; Khan, I A; Shadmani, M
Antimicrobial resistance of 1,113 Streptococcus pneumoniae isolates from patients with respiratory tract infections in Spain: results of a 1-year (1996-1997) multicenter surveillance study. The Spanish Surveillance Group for Respiratory Pathogens.
score: 0.98765888, Antimicrobial agents and chemotherapy, 1999, Baquero, F et. al.
Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts.
score: 0.98765828, Antimicrobial agents and chemotherapy, 2011, Mahanty, S et. al.
The Oligo-Acyl Lysyl Antimicrobial Peptide C12K-2β12 Exhibits a Dual Mechanism of Action and Demonstrates Strong In Vivo Efficacy against Helicobacter pylori.
score: 0.98764648, Antimicrobial agents and chemotherapy, 2012, Makobongo, Morris O et. al.
Structural biology of G protein-coupled receptors
score: 0.98757707, Bioorganic & Medicinal Chemistry Letters, 2005, Lundstrom, Kenneth
Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities.
score: 0.98756222, Antimicrobial agents and chemotherapy, 2012, Moyá, Bartolomé et. al.
Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines
score: 0.98753335, European Journal of Medicinal Chemistry, 2002, Sivakumar, Ramaiya et. al.
Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.
score: 0.9874975, Antimicrobial agents and chemotherapy, 2001, Hochhut, B et. al.
Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp
score: 0.98748801, Bioorganic & Medicinal Chemistry Letters, 2012, Feng, Yunjiang et. al.
Effects of four different meal types on the population pharmacokinetics of single-dose rifapentine in healthy male volunteers.
score: 0.98744879, Antimicrobial agents and chemotherapy, 2010, Zvada, Simbarashe P et. al.
Differential adaptive response and survival of Salmonella enterica serovar enteritidis planktonic and biofilm cells exposed to benzalkonium chloride.
score: 0.98743764, Antimicrobial agents and chemotherapy, 2008, Mangalappalli-Illathu, Anil K et. al.
Synthesis of (−)-lobeline via enzymatic desymmetrization of lobelanidine
score: 0.98743467, Bioorganic & Medicinal Chemistry, 2009, Chênevert, Robert; Morin, Pierre
Synthesis of isothiocyanate-derived mercapturic acids
score: 0.98742511, European Journal of Medicinal Chemistry, 2003, Vermeulen, Martijn et. al.
Pulmonary Disposition of Tedizolid following Administration of Once-Daily Oral 200-Milligram Tedizolid Phosphate in Healthy Adult Volunteers.
score: 0.98740192, Antimicrobial agents and chemotherapy, 2012, Housman, Seth T et. al.
Dose adjustment of polymyxins for renal insufficiency.
score: 0.98730831, Antimicrobial agents and chemotherapy, 2011, Zavascki, Alexandre P
First report of the isolation of high-level vancomycin-resistant Enterococcus faecium from a patient in Japan.
score: 0.98730825, Antimicrobial agents and chemotherapy, 1998, Fujita, N; Yoshimura, M; Komori, T; Tanimoto, K; Ike, Y
Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.
score: 0.98720771, Antimicrobial agents and chemotherapy, 2007, Davis, Timothy M E et. al.
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5′-carboxamidoadenosine analogues
score: 0.98720623, Bioorganic & Medicinal Chemistry, 2006, Rodenko, Boris et. al.
Inhibition of steroid C 17(20) lyase with C-17-heteroaryl steroids
score: 0.98718796, Bioorganic & Medicinal Chemistry, 1996, Burkhart, Joseph P. et. al.
Preparation of l-α-phosphatidyl- d- myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP 2)
score: 0.98715845, Bioorganic & Medicinal Chemistry Letters, 2000, Falck, J.R.; Krishna, U.Murali; Capdevila, Jorge H.
Voriconazole inhibits fungal growth without impairing antigen presentation or T-cell activation.
score: 0.98715802, Antimicrobial agents and chemotherapy, 2003, Van Epps, Heather L; Feldmesser, Marta; Pamer, Eric G
Considerations for the distinction of ccrC-containing staphylococcal cassette chromosome mec elements.
score: 0.98711954, Antimicrobial agents and chemotherapy, 2011, Chlebowicz, Monika A; van Dijl, Jan Maarten; Buist, Girbe
Influence of ligand denticity on the properties of novel 99mTc(I)–carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue
score: 0.98706668, Bioorganic & Medicinal Chemistry, 2012, Fernández, Soledad et. al.
Influence of ligand denticity on the properties of novel 99mTc(I)–carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue
score: 0.98706668, Bioorganic & Medicinal Chemistry, 2012, Fernández, Soledad et. al.
Influence of ligand denticity on the properties of novel 99mTc(I)–carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue
score: 0.98706668, Bioorganic & Medicinal Chemistry, 2012, Fernández, Soledad et. al.
Design, Synthesis and Biological Evaluation of Novel Amino Acid Ureido Derivatives as Aminopeptidase N/CD13 Inhibitors
score: 0.98701583, Bioorganic & Medicinal Chemistry, 2012, Su, Li et. al.
Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in Northern Thailand.
score: 0.98689439, Antimicrobial agents and chemotherapy, 1999, Watt, G et. al.
Decreased bioavailability of rifampin and other antituberculosis drugs in patients with advanced human immunodeficiency virus disease.
score: 0.98686041, Antimicrobial agents and chemotherapy, 2004, Gurumurthy, Prema et. al.
Clarithromycin delays progression of bronchial epithelial cells from G1 phase to S phase and delays cell growth via extracellular signal-regulated protein kinase suppression.
score: 0.98682571, Antimicrobial agents and chemotherapy, 2006, Shinkai, Masaharu et. al.
A variant peptide of buffalo colostrum β-lactoglobulin inhibits angiotensin I-converting enzyme activity
score: 0.98682514, European Journal of Medicinal Chemistry, 2012, Rohit, A.C.; Sathisha, K.; Aparna, H.S.
A variant peptide of buffalo colostrum β-lactoglobulin inhibits angiotensin I-converting enzyme activity
score: 0.98682514, European Journal of Medicinal Chemistry, 2012, Rohit, A.C.; Sathisha, K.; Aparna, H.S.
Inhibitor-resistant TEM beta-lactamases: revision of the TEM-41 sequence.
score: 0.98679619, Antimicrobial agents and chemotherapy, 1998, Labia, R et. al.
Iridoid glucosides from Nyctanthes arbortristis results in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite
score: 0.98678775, European Journal of Medicinal Chemistry, 2012, Shukla, Anil Kumar; Patra, Sanjukta; Dubey, Vikash Kumar
Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT
score: 0.9867841, Bioorganic & Medicinal Chemistry, 2009, Esposito, Veronica et. al.
Presence of dfr6 gene cassette in superintegron of non-O1/non-O139 strain of Vibrio cholerae.
score: 0.9866394, Antimicrobial agents and chemotherapy, 2009, Kumar, Praveen; Thomas, Sabu
Extended -10 promoter in ISAba-1 upstream of blaOXA-23 from Acinetobacter baumannii.
score: 0.98663282, Antimicrobial agents and chemotherapy, 2007, Segal, Heidi et. al.
Predictive genotypic algorithm for virologic response to lopinavir-ritonavir in protease inhibitor-experienced patients.
score: 0.9865022, Antimicrobial agents and chemotherapy, 2007, King, Martin S et. al.
Renin inhibitors: C-terminal oxetanes as potent transition-state mimics
score: 0.9865008, Bioorganic & Medicinal Chemistry, 1994, Rosenberg, Saul H. et. al.
Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria.
score: 0.98649127, Antimicrobial agents and chemotherapy, 2011, Rijken, Marcus J et. al.
Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.
score: 0.98648754, Antimicrobial agents and chemotherapy, 1999, McConkey, G A
Estimate of the frequency of human immunodeficiency virus type 1 protease inhibitor resistance within unselected virus populations in vitro.
score: 0.98647116, Antimicrobial agents and chemotherapy, 1998, Tucker, S P et. al.
Preparation of conophylline affinity nano-beads and identification of a target protein
score: 0.98646673, Bioorganic & Medicinal Chemistry, 2009, Suzuki, Eriko et. al.
Dietary inclusion of colicin e1 is effective in preventing postweaning diarrhea caused by F18-positive Escherichia coli in pigs.
score: 0.9864595, Antimicrobial agents and chemotherapy, 2007, Cutler, S A et. al.
Virologic failure in first-line human immunodeficiency virus therapy with a CCR5 entry inhibitor, aplaviroc, plus a fixed-dose combination of lamivudine-zidovudine: nucleoside reverse transcriptase inhibitor resistance regardless of envelope tropism.
score: 0.98644299, Antimicrobial agents and chemotherapy, 2009, Demarest, James F et. al.
Linezolid activity compared to those of selected macrolides and other agents against aerobic and anaerobic pathogens isolated from soft tissue bite infections in humans.
score: 0.98638953, Antimicrobial agents and chemotherapy, 1999, Goldstein, E J; Citron, D M; Merriam, C V
Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro.
score: 0.98635848, Antimicrobial agents and chemotherapy, 2000, Bina, J E et. al.
Chemically-tagged mitsunobu reagents for use in solution-phase chemical library synthesis
score: 0.98635373, Bioorganic & Medicinal Chemistry Letters, 1998, Starkey, Gale W.; Parlow, John J.; Flynn, Daniel L.
Investigations toward the selection of fully-modified 4′-thioRNA aptamers: Optimization of in vitro transcription steps in the presence of 4′-thioNTPs
score: 0.9862013, Bioorganic & Medicinal Chemistry, 2008, Minakawa, Noriaki; Sanji, Mioko; Kato, Yuka; Matsuda, Akira
Defining fractional inhibitory concentration index cutoffs for additive interactions based on self-drug additive combinations, Monte Carlo simulation analysis, and in vitro-in vivo correlation data for antifungal drug combinations against Aspergillus fumigatus.
score: 0.98611002, Antimicrobial agents and chemotherapy, 2010, Meletiadis, Joseph et. al.
In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions.
score: 0.98610933, Antimicrobial agents and chemotherapy, 2001, Gomi, H et. al.
Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice.
score: 0.98604686, Antimicrobial agents and chemotherapy, 1998, Matsuo, H et. al.
Regulation of RamA by RamR in Salmonella enterica Serovar Typhimurium: Isolation of a RamR Superrepressor.
score: 0.98603171, Antimicrobial agents and chemotherapy, 2012, Ricci, Vito; Busby, Stephen J W; Piddock, Laura J V
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada.
score: 0.98594706, Antimicrobial agents and chemotherapy, 2004, Boyd, David A et. al.
Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist
score: 0.98590393, Bioorganic & Medicinal Chemistry, 2012, Ban, Shintaro et. al.
Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux.
score: 0.98585688, Antimicrobial agents and chemotherapy, 2008, Périchon, Bruno et. al.
An oxidatively releasable caging group that senses lipid peroxidation
score: 0.98576325, Bioorganic & Medicinal Chemistry Letters, 2005, Trumbull, Kari A.; Branchaud, Bruce P.
Chiral arylpyrrolidinols: preparation and biological profile
score: 0.98574871, Bioorganic & Medicinal Chemistry, 2005, Collina, Simona et. al.
Cefepime versus ceftriaxone for empiric treatment of hospitalized patients with community-acquired pneumonia.
score: 0.98572786, Antimicrobial agents and chemotherapy, 1999, Borja, J; Jané, F
Phase I evaluation of the safety and pharmacokinetics of a single-dose intravenous injection of a murine monoclonal antibody against Hantaan virus in healthy volunteers.
score: 0.98561697, Antimicrobial agents and chemotherapy, 2009, Xu, Rong et. al.
Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells
score: 0.98556479, Bioorganic & Medicinal Chemistry, 2003, Shikata, Keiji et. al.
Macrolide and tetracycline resistance and molecular relationships of clinical strains of Streptococcus agalactiae.
score: 0.98554573, Antimicrobial agents and chemotherapy, 2002, Culebras, Esther et. al.
Activity of a tamoxifen–Raloxifene hybrid ligand for estrogen receptors at an AP-1 Site
score: 0.98542822, Bioorganic & Medicinal Chemistry Letters, 2001, Weatherman, Ross V.; Carroll, David C.; Scanlan, Thomas S.
Diversity of beta-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae.
score: 0.98535246, Antimicrobial agents and chemotherapy, 2002, Dabernat, Henri et. al.
Minocycline and cefotaxime in the treatment of experimental murine Vibrio vulnificus infection.
score: 0.98531242, Antimicrobial agents and chemotherapy, 1998, Chuang, Y C et. al.
Aminoglycoside resistance in Pseudomonas aeruginosa.
score: 0.98518173, Antimicrobial agents and chemotherapy, 2005, Poole, Keith
Comparative in vitro activities of meropenem, imipenem, temocillin, piperacillin, and ceftazidime in combination with tobramycin, rifampin, or ciprofloxacin against Burkholderia cepacia isolates from patients with cystic fibrosis.
score: 0.98517556, Antimicrobial agents and chemotherapy, 1999, Bonacorsi, S; Fitoussi, F; Lhopital, S; Bingen, E
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
score: 0.98517203, Bioorganic & Medicinal Chemistry, 2012, Kniess, Torsten et. al.
Promising carboranylquinazolines for boron neutron capture therapy: Synthesis, characterization, and in vitro toxicity evaluation
score: 0.98503402, European Journal of Medicinal Chemistry, 2009, Genady, Afaf R.
Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model.
score: 0.98501454, Antimicrobial agents and chemotherapy, 2006, Patton, D L et. al.
Population pharmacokinetics and pharmacodynamics of caspofungin in pediatric patients.
score: 0.98487876, Antimicrobial agents and chemotherapy, 2011, Li, Chi-Chung et. al.
Some aspect of the interactions of adriamycin with human serum albumin
score: 0.98485286, Bioorganic & Medicinal Chemistry, 1996, Trynda-Lemiesz, Lilianna; Kozlowski, Henryk
Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli.
score: 0.98477607, Antimicrobial agents and chemotherapy, 1999, Laraki, N et. al.
Production of isoprenoid pharmaceuticals by engineered microbes.
score: 0.98464982, Nature chemical biology, 2006, Chang, Michelle C Y; Keasling, Jay D
In vitro susceptibilities of Mycoplasma hominis to six fluoroquinolones as determined by E test.
score: 0.98460539, Antimicrobial agents and chemotherapy, 1999, Waites, K B; Canupp, K C; Kenny, G E
Pharmacometrics-based dose selection of levofloxacin as a treatment for postexposure inhalational anthrax in children.
score: 0.98449827, Antimicrobial agents and chemotherapy, 2010, Li, Fang et. al.
Redox-changes associated with the glutathione-dependent ability of the Cu(II)–GSSG complex to generate superoxide
score: 0.98447, Bioorganic & Medicinal Chemistry, 2012, Aliaga, Margarita E. et. al.
Redox-changes associated with the glutathione-dependent ability of the Cu(II)–GSSG complex to generate superoxide
score: 0.98447, Bioorganic & Medicinal Chemistry, 2012, Aliaga, Margarita E. et. al.
Structure-Requirements of isocoumarins, phthalides, and stilbenes from hydrangeae dulcis folium for inhibitory activity on histamine release from rat peritoneal mast cells
score: 0.98445954, Bioorganic & Medicinal Chemistry, 1999, Matsuda, Hisashi; Shimoda, Hiroshi; Yoshikawa, Masayuki
Subinhibitory concentrations of antimicrobial agents reduce the uptake of Legionella pneumophila into Acanthamoeba castellanii and U937 cells by altering the expression of virulence-associated antigens.
score: 0.98438836, Antimicrobial agents and chemotherapy, 1998, Lück, P C; Schmitt, J W; Hengerer, A; Helbig, J H
Bac 32, a novel bacteriocin widely disseminated among clinical isolates of Enterococcus faecium.
score: 0.98435192, Antimicrobial agents and chemotherapy, 2006, Inoue, Takako; Tomita, Haruyoshi; Ike, Yasuyoshi
Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs
score: 0.9842716, Bioorganic & Medicinal Chemistry, 2007, Duca, Maria et. al.
Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin.
score: 0.98425529, Antimicrobial agents and chemotherapy, 2005, Helmick, Ryan A et. al.
Pharmacokinetics of caspofungin in two patients with burn injuries.
score: 0.98416175, Antimicrobial agents and chemotherapy, 2012, Jullien, V; Blanchet, B; Benyamina, M; Tod, M; Vinsonneau, C
New approach for the synthesis of [ 18F]fluoroethyltyrosine for cancer imaging: Simple, fast, and high yielding automated synthesis
score: 0.98406574, Bioorganic & Medicinal Chemistry, 2009, Zuhayra, M. et. al.
The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2'-deoxy-3'-thiacytidine and a reduced ability to synthesize viral DNA.
score: 0.9839393, Antimicrobial agents and chemotherapy, 1998, Ladner, S K; Miller, T J; King, R W
Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory season.
score: 0.98391575, Antimicrobial agents and chemotherapy, 2000, Jones, M E et. al.
Trends in antimicrobial resistance among clinical isolates of the Bacteroides fragilis group from 1992 to 1997 in Montreal, Canada.
score: 0.98383851, Antimicrobial agents and chemotherapy, 1999, Labbé, A C et. al.
Prevalence and risk factors for aminoglycoside nephrotoxicity in intensive care units.
score: 0.98383131, Antimicrobial agents and chemotherapy, 2009, Oliveira, João F P et. al.
Multidose pharmacokinetics of ritonavir and zidovudine in human immunodeficiency virus-infected patients.
score: 0.98375734, Antimicrobial agents and chemotherapy, 1998, Cato, A; Qian, J; Hsu, A; Levy, B; Leonard, J; Granneman, R
Design of artificial nucleobases for the recognition of the AT inversion by triple-helix forming oligonucleotides: A structure–stability relationship study and neighbour bases effect
score: 0.98375111, Bioorganic & Medicinal Chemistry, 2003, Guianvarc'h, Dominique et. al.
Azithromycin as treatment for disseminated Mycobacterium avium complex in AIDS patients.
score: 0.98371886, Antimicrobial agents and chemotherapy, 1999, Koletar, S L et. al.
Effect of interleukin-10 on gut-derived sepsis caused by Pseudomonas aeruginosa in mice.
score: 0.98371715, Antimicrobial agents and chemotherapy, 1998, Matsumoto, T et. al.
Caspofungin uptake is mediated by a high-affinity transporter in Candida albicans.
score: 0.98367595, Antimicrobial agents and chemotherapy, 2004, Paderu, Padmaja; Park, Steven; Perlin, David S
High throughput artificial membrane permeability assay for blood–brain barrier
score: 0.9836654, European Journal of Medicinal Chemistry, 2003, Di, Li et. al.
Cell adhesion inhibitory activity of ( d)-corynoline, a hexahydrobenzo[ c]phenanthridine-type alkaloid, and its structure–activity relationship, studied by X-ray crystal structure analysis and molecular docking study
score: 0.9835793, Bioorganic & Medicinal Chemistry, 2005, Kamigauchi, Miyoko et. al.
Killing activities of trovafloxacin alone and in combination with beta-lactam agents, rifampin, or vancomycin against Streptococcus pneumoniae isolates with various susceptibilities to extended-spectrum cephalosporins at concentrations clinically achievable in cerebrospinal fluid.
score: 0.98346082, Antimicrobial agents and chemotherapy, 1999, Fitoussi, F; Doit, C; Geslin, P; Bingen, E
New aromatase inhibitors. Synthesis and biological activity of aryl-substituted pyrrolizine and indolizine derivatives
score: 0.98345862, Bioorganic & Medicinal Chemistry, 2000, Sonnet, Pascal et. al.
A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography?
score: 0.983402, Bioorganic & Medicinal Chemistry Letters, 2007, Yu, G. et. al.
Thermodynamics and fluorescence studies of the interactions of cyclooctapeptides with Hg 2+, Pb 2+, and Cd 2+
score: 0.98335091, Bioorganic & Medicinal Chemistry, 2008, Ngu-Schwemlein, Maria et. al.
Synthesis of nuclease-resistant siRNAs possessing benzene-phosphate backbones in their 3′-overhang regions
score: 0.98319176, Bioorganic & Medicinal Chemistry Letters, 2008, Ueno, Yoshihito et. al.
Synthesis and biological evaluation of a new class of glycoconjugated disulfides that exhibit potential anticancer properties
score: 0.98318327, Bioorganic & Medicinal Chemistry, 2012, Bonaccorsi, Paola et. al.
Synthesis and biological evaluation of a new class of glycoconjugated disulfides that exhibit potential anticancer properties
score: 0.98318327, Bioorganic & Medicinal Chemistry, 2012, Bonaccorsi, Paola et. al.
Synthesis and biological evaluation of a new class of glycoconjugated disulfides that exhibit potential anticancer properties
score: 0.98318327, Bioorganic & Medicinal Chemistry, 2012, Bonaccorsi, Paola et. al.
Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase
score: 0.98316914, Bioorganic & Medicinal Chemistry, 2000, Pochet, Lionel et. al.
In vitro and in vivo activities of Syn2190, a novel beta-lactamase inhibitor.
score: 0.98316619, Antimicrobial agents and chemotherapy, 1999, Nishida, K et. al.
Molecular epidemiology and prevalence of macrolide efflux genes mef(A) and mef(E) in Streptococcus pneumoniae obtained in Canada from 1997 to 2002.
score: 0.98310151, Antimicrobial agents and chemotherapy, 2005, Wierzbowski, Aleksandra K et. al.
Hybrid molecules of carvacrol and benzoyl urea/thiourea with potential applications in agriculture and medicine
score: 0.98301901, Bioorganic & Medicinal Chemistry Letters, 2012, Pete, Umesh D. et. al.
Development of rifapentine susceptibility tests for Mycobacterium tuberculosis.
score: 0.98300954, Antimicrobial agents and chemotherapy, 1999, Heifets, L; Sanchez, T; Vanderkolk, J; Pham, V
Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells
score: 0.98296856, Bioorganic & Medicinal Chemistry Letters, 2012, Oishi, Tohru et. al.
Resistance to beta-lactam antibiotics in Pseudomonas aeruginosa due to interplay between the MexAB-OprM efflux pump and beta-lactamase.
score: 0.9829446, Antimicrobial agents and chemotherapy, 1999, Nakae, T; Nakajima, A; Ono, T; Saito, K; Yoneyama, H
Detection of live and antibiotic-killed bacteria by quantitative real-time PCR of specific fragments of rRNA.
score: 0.98293077, Antimicrobial agents and chemotherapy, 2006, Aellen, Steve et. al.
Penetration of rufloxacin into the cerebrospinal fluid in patients with inflamed and uninflamed meninges.
score: 0.98282601, Antimicrobial agents and chemotherapy, 2000, Moretti, M V; Pauluzzi, S; Cesana, M
Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.
score: 0.9828243, Antimicrobial agents and chemotherapy, 1998, Jensen-Pergakes, K L et. al.
A new bioconcentration factor model based on SMILES and indices of presence of atoms
score: 0.98277049, European Journal of Medicinal Chemistry, 2010, Toropova, A.P. et. al.
Mycobacteriocidal action of exogenous nitric oxide.
score: 0.98276869, Antimicrobial agents and chemotherapy, 1999, Long, R; Light, B; Talbot, J A
Peptide antibiotics.
score: 0.98276527, Antimicrobial agents and chemotherapy, 1999, Hancock, R E; Chapple, D S
Cyclodextrin–peptide hybrid as a hydrolytic catalyst having multiple functional groups
score: 0.98272794, Bioorganic & Medicinal Chemistry Letters, 2000, Tsutsumi, Hiroshi et. al.
Structural investigation of PAP derivatives by CoMFA and CoMSIA reveals novel insight towards inhibition of Bcr-Abl oncoprotein
score: 0.98270044, Journal of Molecular Graphics and Modelling, 2007, San Juan, Amor A.
Interactions of some modified mono- and bis-β-cyclodextrins with bovine serum albumin
score: 0.98264507, Bioorganic & Medicinal Chemistry, 2006, Gao, Hui; Wang, Yi-Nong; Fan, Yun-Ge; Ma, Jian-Biao
Gold nanoparticles conjugated with monosaccharide-modified peptide for lectin detection
score: 0.9825379, Bioorganic & Medicinal Chemistry Letters, 2012, Tsutsumi, Hiroshi et. al.
New mutations and horizontal transfer of rpoB among rifampin-resistant Streptococcus pneumoniae from four Spanish hospitals.
score: 0.98252797, Antimicrobial agents and chemotherapy, 2005, Ferrándiz, María José et. al.
Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate.
score: 0.98252709, Antimicrobial agents and chemotherapy, 2003, Chenel, Marylore et. al.
Modeling and interactions of Aspergillus fumigatus lanosterol 14-α demethylase `A' with azole antifungals
score: 0.98243747, Bioorganic & Medicinal Chemistry, 2004, Gollapudy, Reena; Ajmani, Subhash; Kulkarni, Sudhir A.
Investigation on PEGylation strategy of recombinant human interleukin-1 receptor antagonist
score: 0.98241062, Bioorganic & Medicinal Chemistry, 2007, Yu, Pengzhan et. al.
A relationship between amide hydrogen bond strength and quinone reduction potential: Implications for photosystem I and bacterial reaction center quinone function
score: 0.98240761, Bioorganic & Medicinal Chemistry Letters, 2007, Feldman, Ken S.; Hester, D. Keith; Golbeck, John H.
Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
score: 0.98238266, Antimicrobial agents and chemotherapy, 2005, Anderson, Timothy J C et. al.
In vitro and in vivo activities of NS-718, a new lipid nanosphere incorporating amphotericin B, against Aspergillus fumigatus.
score: 0.98238084, Antimicrobial agents and chemotherapy, 1999, Otsubo, T et. al.
1′ S-1′-Acetoxychavicol acetate as a new type inhibitor of interferon-β production in lipopolysaccharide-activated mouse peritoneal macrophages
score: 0.98234303, Bioorganic & Medicinal Chemistry, 2005, Ando, Shin et. al.
Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes
score: 0.98234275, European Journal of Medicinal Chemistry, 2010, Sathyaraj, Gopal et. al.
Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads.
score: 0.98233522, Antimicrobial agents and chemotherapy, 1998, Nicolau, D P et. al.
Synthesis and characterization of polyoxometalates loaded starch nanocomplex and its antitumoral activity
score: 0.98227311, European Journal of Medicinal Chemistry, 2008, Zhai, Fengying et. al.
Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry
score: 0.98220324, Bioorganic & Medicinal Chemistry, 1997, Ganguly, A.K. et. al.
Genetic and functional variability of AmpC-type β-lactamases from Acinetobacter baumannii.
score: 0.98215534, Antimicrobial agents and chemotherapy, 2010, Rodríguez-Martínez, José-Manuel et. al.
Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs.
score: 0.98214406, Antimicrobial agents and chemotherapy, 1999, Kim, S H; Kwon, J W; Kim, W B; Lee, M G
Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations
score: 0.98212654, European Journal of Medicinal Chemistry, 2009, Önal, Armağan
Affinity separation of polyribonucleotide-binding human blood proteins
score: 0.98202279, Bioorganic & Medicinal Chemistry Letters, 2006, Gerasimova, Yuliya V. et. al.
Chemical probes: sharpen your epigenetic tools.
score: 0.98187036, Nature chemical biology, 2011, Hauser, Alexander-Thomas; Jung, Manfred
Phase I dose escalation study to evaluate the safety and pharmacokinetic profile of tefibazumab in subjects with end-stage renal disease requiring hemodialysis.
score: 0.9818163, Antimicrobial agents and chemotherapy, 2006, Hetherington, Seth et. al.
The integral role of triacyl glycerols in the biosynthesis of the aldehydic sex pheromones of Manduca sexta (L.)
score: 0.98181479, Bioorganic & Medicinal Chemistry, 1996, Tumlinson, James H.; Teal, Peter E.A.; Fang, Nianbai
Tau protein and tau aggregation inhibitors
score: 0.98180887, Neuropharmacology, 2010, Bulic, Bruno et. al.
Frequentist and Bayesian pharmacometric-based approaches to facilitate critically needed new antibiotic development: overcoming lies, damn lies, and statistics.
score: 0.98167841, Antimicrobial agents and chemotherapy, 2012, Ambrose, Paul G et. al.
Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery
score: 0.98167297, European Journal of Medicinal Chemistry, 2012, Chen, Haigang et. al.
Mycobacterium avium grown in Acanthamoeba castellanii is protected from the effects of antimicrobials.
score: 0.981652, Antimicrobial agents and chemotherapy, 2000, Miltner, E C; Bermudez, L E
Comparison of simultaneous splenic sample PCR with blood sample PCR for diagnosis and treatment of experimental Ehrlichia canis infection.
score: 0.98162668, Antimicrobial agents and chemotherapy, 2004, Harrus, Shimon et. al.
Enhanced saquinavir exposure in human immunodeficiency virus type 1-infected patients with diarrhea and/or wasting syndrome.
score: 0.98160138, Antimicrobial agents and chemotherapy, 2004, Trout, Hervé et. al.
Novel antiseptic urinary catheters for prevention of urinary tract infections: correlation of in vivo and in vitro test results.
score: 0.98156407, Antimicrobial agents and chemotherapy, 2009, Hachem, Ray et. al.
PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes
score: 0.98153499, Bioorganic & Medicinal Chemistry, 2012, Ingallinella, Paolo et. al.
PEGylation of Neuromedin U yields a promising candidate for the reatment of obesity and diabetes
score: 0.98153499, Bioorganic & Medicinal Chemistry, 2012, Ingallinella, Paolo et. al.
Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids
score: 0.98147449, Bioorganic & Medicinal Chemistry, 2006, Chen, Wang et. al.
Anomalous temperature dependence of peptide films at air–water interface
score: 0.98142322, Bioorganic & Medicinal Chemistry Letters, 2000, Jayakumar, R.; Murugesan, M.
Mechanisms of action of escapin, a bactericidal agent in the ink secretion of the sea hare Aplysia californica: rapid and long-lasting DNA condensation and involvement of the OxyR-regulated oxidative stress pathway.
score: 0.98136993, Antimicrobial agents and chemotherapy, 2012, Ko, Ko-Chun; Tai, Phang C; Derby, Charles D
Chitosan acetate bandage as a topical antimicrobial dressing for infected burns.
score: 0.98128758, Antimicrobial agents and chemotherapy, 2009, Dai, Tianhong et. al.
Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria
score: 0.98127611, Bioorganic & Medicinal Chemistry, 2010, Tamborrini, Marco et. al.
High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens.
score: 0.98124688, Antimicrobial agents and chemotherapy, 2006, Doualla-Bell, Florence et. al.
Dopamine/serotonin receptor ligands. Part VIII [1]:the dopamine receptor antagonist LE300 - modelled and X-ray structure plus further pharmacological characterization, including serotonin receptor binding, biogenic amine transporter testing and in vivo testings
score: 0.98122448, European Journal of Medicinal Chemistry, 2004, Decker, Michael et. al.
Prevalence of oxacillin resistance in Staphylococcus aureus among inpatients and outpatients in the United States during 2000.
score: 0.98108741, Antimicrobial agents and chemotherapy, 2002, Jones, Mark E et. al.
Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae.
score: 0.98106781, Antimicrobial agents and chemotherapy, 2005, Gacar, Gulcin G et. al.
Molecular characterization of off-target activities of telithromycin: a potential role for nicotinic acetylcholine receptors.
score: 0.98102578, Antimicrobial agents and chemotherapy, 2010, Bertrand, Daniel et. al.
Hybrid oligonucleotides: Synthesis, biophysical properties, stability studies, and biological activity
score: 0.98088649, Bioorganic & Medicinal Chemistry, 1996, Yu, Dong et. al.
An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57.
score: 0.98051139, Antimicrobial agents and chemotherapy, 2001, Weitnauer, G et. al.
Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis
score: 0.9804423, Bioorganic & Medicinal Chemistry, 2005, Li, Aiying et. al.
Gene cassettes potentially encoding fosfomycin resistance determinants.
score: 0.98040818, Antimicrobial agents and chemotherapy, 2005, Partridge, Sally R; Hall, Ruth M
Quantitation of Candida albicans ergosterol content improves the correlation between in vitro antifungal susceptibility test results and in vivo outcome after fluconazole treatment in a murine model of invasive candidiasis.
score: 0.98030658, Antimicrobial agents and chemotherapy, 2000, Arthington-Skaggs, B A; Warnock, D W; Morrison, C J
Synthesis and antitumor studies on novel Co(II), Ni(II) and Cu(II) metal complexes of bis(3-acetylcoumarin)thiocarbohydrazone
score: 0.98029564, European Journal of Medicinal Chemistry, 2008, Sathisha, M.P. et. al.
CTX-M-2 and a new CTX-M-39 enzyme are the major extended-spectrum beta-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel.
score: 0.9802071, Antimicrobial agents and chemotherapy, 2005, Chmelnitsky, Inna et. al.
Oxfendazole treatment of sheep with naturally acquired hydatid disease.
score: 0.9801532, Antimicrobial agents and chemotherapy, 1999, Dueger, E L; Moro, P L; Gilman, R H
Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18.
score: 0.98012518, Antimicrobial agents and chemotherapy, 2000, Rasheed, J K et. al.
A point mutation associated with bacterial macrolide resistance is present in both 23S rRNA genes of an erythromycin-resistant Treponema pallidum clinical isolate.
score: 0.98004053, Antimicrobial agents and chemotherapy, 2000, Stamm, L V; Bergen, H L
Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.
score: 0.98004053, Antimicrobial agents and chemotherapy, 2011, Li, Wei et. al.
Peptide–polyethylene glycol conjugates: Synthesis and properties of peptides bearing a C-terminal polyethylene glycol chain
score: 0.98003389, Bioorganic & Medicinal Chemistry, 2006, Grun, Jessica et. al.
Manganese-Based complexes of radical scavengers as neuroprotective agents
score: 0.97997064, Bioorganic & Medicinal Chemistry, 2003, Vajragupta, Opa et. al.
Morphological effects of miconazole on Helicobacter pylori.
score: 0.9799167, Antimicrobial agents and chemotherapy, 1998, von Recklinghausen, G; Schmid, E N; Vollmer, A; Ansorg, R
Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents
score: 0.97989665, European Journal of Medicinal Chemistry, 2012, Abdel-Wahab, Bakr F. et. al.
Evaluation of standard- and high-dose daptomycin versus linezolid against vancomycin-resistant Enterococcus isolates in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations.
score: 0.97988473, Antimicrobial agents and chemotherapy, 2012, Hall, Ashley D et. al.
Multilaboratory comparison of proficiencies in susceptibility testing of Helicobacter pylori and correlation between agar dilution and E test methods.
score: 0.97971734, Antimicrobial agents and chemotherapy, 2003, Best, L M et. al.
Polyhalogenobenzimidazoles: synthesis and Their inhibitory activity against casein kinases
score: 0.97970098, Bioorganic & Medicinal Chemistry, 2003, Andrzejewska, Mariola et. al.
Rapid inversion of the prevalences of macrolide resistance phenotypes paralleled by a diversification of T and emm types among Streptococcus pyogenes in Portugal.
score: 0.97963651, Antimicrobial agents and chemotherapy, 2005, Silva-Costa, C et. al.
PCR-restriction fragment length polymorphism can also detect point mutation A2142C in the 23S rRNA gene, associated with Helicobacter pylori resistance to clarithromycin.
score: 0.97956238, Antimicrobial agents and chemotherapy, 2002, Ménard, Armelle et. al.
Synthesis, binding and structure–affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS)
score: 0.97952683, Bioorganic & Medicinal Chemistry, 2000, Poirot, Marc et. al.
Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke
score: 0.97948868, Bioorganic & Medicinal Chemistry, 2006, Khalil, Ashraf A.; Davies, Bruce; Castagnoli, Neal
Antibiotic susceptibility of invasive Haemophilus influenzae strains in Canada.
score: 0.97945479, Antimicrobial agents and chemotherapy, 2008, Sill, Michelle L; Tsang, Raymond S W
Study of the binding affinity for corticosteroid-binding globulin (CBG) using the electron topological method (ETM) as three-dimensional quantitative structure–activity relationship (3D QSAR)
score: 0.97944086, Bioorganic & Medicinal Chemistry, 2003, Guzel, Yahya; Ozturk, Emel
Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.
score: 0.97940579, Antimicrobial agents and chemotherapy, 1999, Moore, R A et. al.
Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.
score: 0.97935821, Antimicrobial agents and chemotherapy, 1999, Torres-Santos, E C et. al.
Quantitative 31P NMR detection of oxygen-centered and carbon-centered radical species
score: 0.9793506, Bioorganic & Medicinal Chemistry, 2006, Argyropoulos, Dimitris S. et. al.
Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009.
score: 0.97934956, Antimicrobial agents and chemotherapy, 2011, Hammond, Sarah P; Baden, Lindsey R; Marty, Francisco M
Pharmacokinetic-pharmacodynamic relationships describing the efficacy of oritavancin in patients with Staphylococcus aureus bacteremia.
score: 0.97933099, Antimicrobial agents and chemotherapy, 2006, Bhavnani, Sujata M et. al.
Novel anthraquinone derivatives with redox-active functional groups capable of producing free radicals by metabolism: are free radicals essential for cytotoxicity?
score: 0.97929287, European Journal of Medicinal Chemistry, 1999, Barasch, Dinorah et. al.
New Mg2+-dependent oxytetracycline resistance determinant tet 34 in Vibrio isolates from marine fish intestinal contents.
score: 0.9792593, Antimicrobial agents and chemotherapy, 2002, Nonaka, Lisa; Suzuki, Satoru
Structure-function relationship studies on the frog skin antimicrobial peptide tigerinin 1: design of analogs with improved activity and their action on clinical bacterial isolates.
score: 0.97912567, Antimicrobial agents and chemotherapy, 2002, Sitaram, Narasimhaiah et. al.
Prevalence and Significance of HIV-1 Drug Resistance Mutations among Patients on Antiretroviral Therapy with Detectable Low-Level Viremia.
score: 0.97910448, Antimicrobial agents and chemotherapy, 2012, Li, Jonathan Z et. al.
Experimental phage therapy against Staphylococcus aureus in mice.
score: 0.97907149, Antimicrobial agents and chemotherapy, 2007, Capparelli, Rosanna et. al.
Determinants of quinolone versus trimethoprim-sulfamethoxazole use for outpatient urinary tract infection.
score: 0.97901628, Antimicrobial agents and chemotherapy, 2012, Stuck, Anna K et. al.
Inhibition of quorum sensing regulated biofilm formation in Serratia marcescens causing nosocomial infections
score: 0.978995, Bioorganic & Medicinal Chemistry Letters, 2012, Bakkiyaraj, Dhamodharan et. al.
Structure–activity relationships in a series of 8-substituted xanthines as A 1-adenosine receptor antagonists
score: 0.97895412, Bioorganic & Medicinal Chemistry, 2001, Strappaghetti, Giovannella et. al.
The new models of the human telomere d[AGGG(TTAGGG) 3] in K + solution
score: 0.97885391, Bioorganic & Medicinal Chemistry, 2006, Xu, Yan; Noguchi, Yuki; Sugiyama, Hiroshi
QSAR and complex network study of the chiral HMGR inhibitor structural diversity
score: 0.97883391, Bioorganic & Medicinal Chemistry, 2009, García, Isela et. al.
Microbial biotransformations of a synthetic immunomodulating agent, HR325
score: 0.97881685, Bioorganic & Medicinal Chemistry, 1997, Lacroix, Isabelle; Biton, Jacques; Azerad, Robert
Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study.
score: 0.9788077, Antimicrobial agents and chemotherapy, 2001, van Doorn, L J et. al.
α-Cyanocinnamide derivatives: a new family of non-peptide, non-sulfhydryl inhibitors of ras farnesylation
score: 0.97878383, Bioorganic & Medicinal Chemistry, 1999, Poradosu, Enrique et. al.
Synthesis and antitumour activity of new dendritic polyamines–(imide–DNA-intercalator) conjugates: potent Lck inhibitors
score: 0.97875101, European Journal of Medicinal Chemistry, 2002, Braña, Miguel F. et. al.
Functionalization of the 4,4-difluoro-4-bora-3a,4a-diaza- s-indacene (BODIPY) core
score: 0.9787418, Bioorganic & Medicinal Chemistry Letters, 2008, Li, Lingling; Nguyen, Binh; Burgess, Kevin
Total synthesis and adjuvant activity of all stereoisomers of pinellic acid
score: 0.97873648, Bioorganic & Medicinal Chemistry Letters, 2003, Shirahata, Tatsuya et. al.
Practical management of boceprevir and immunosuppressive therapy in liver transplant recipients with hepatitis C virus recurrence.
score: 0.97873593, Antimicrobial agents and chemotherapy, 2012, Coilly, Audrey et. al.
Ligand recognition by the vitamin D receptor
score: 0.97870051, Bioorganic & Medicinal Chemistry, 2001, Choi, Mihwa et. al.
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
score: 0.97869007, Antimicrobial agents and chemotherapy, 2012, Betuela, Inoni et. al.
Synthesis of 6- N-(benzothiazol-2-yl)deoxyadenosine and its exciton-coupled circular dichroism
score: 0.97868791, Bioorganic & Medicinal Chemistry, 2010, Masaki, Yoshiaki et. al.
Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics
score: 0.97863838, Bioorganic & Medicinal Chemistry, 2004, Taguchi, Takaaki et. al.
Efficacy of high doses of levofloxacin in experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus.
score: 0.97856736, Antimicrobial agents and chemotherapy, 2006, Murillo, O et. al.
Microbial growth inhibition by alternating electric fields in mice with Pseudomonas aeruginosa lung infection.
score: 0.97855971, Antimicrobial agents and chemotherapy, 2010, Giladi, Moshe et. al.
Controlled expression of an rpoS antisense RNA can inhibit RpoS function in Escherichia coli.
score: 0.97852983, Antimicrobial agents and chemotherapy, 2003, Chen, Guozhu; Patten, Cheryl L; Schellhorn, Herb E
Synthesis and biological testings as inhibitors of HMGCoA reductase of the seco-acid of tuckolide and its C-7 epimer
score: 0.97846271, Bioorganic & Medicinal Chemistry, 1999, Colle, Stéphane et. al.
Body weight cutoff for daily dosage of efavirenz and 60-week efficacy of efavirenz-based regimen in human immunodeficiency virus and tuberculosis coinfected patients receiving rifampin.
score: 0.97846169, Antimicrobial agents and chemotherapy, 2009, Manosuthi, Weerawat et. al.
Cardioprotective potential ofN,α-l-rhamnopyranosyl vincosamide, an indole alkaloid, isolated from the leaves ofMoringa oleiferain isoproterenol induced cardiotoxic rats: In vivo and in vitro studies
score: 0.97845469, Bioorganic & Medicinal Chemistry Letters, 2013, Panda, Sunanda; Kar, Anand; Sharma, Pratibha; Sharma, Ashok
Cardioprotective potential ofN,α-l-rhamnopyranosyl vincosamide, an indole alkaloid, isolated from the leaves ofMoringa oleiferain isoproterenol induced cardiotoxic rats: In vivo and in vitro studies
score: 0.97845469, Bioorganic & Medicinal Chemistry Letters, 2013, Panda, Sunanda; Kar, Anand; Sharma, Pratibha; Sharma, Ashok
Antileishmanial agents part-IV: synthesis and antileishmanial activity of novel terpenyl pyrimidines
score: 0.97839599, European Journal of Medicinal Chemistry, 2005, Chandra, Naveen et. al.
Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents
score: 0.97838607, European Journal of Medicinal Chemistry, 2012, Abdel-Wahab, Bakr F. et. al.
Pharmacokinetics of doxycycline in adults with cystic fibrosis.
score: 0.97826889, Antimicrobial agents and chemotherapy, 2012, Beringer, Paul M et. al.
Levofloxacin and moxifloxacin increase human gut colonization by Candida species.
score: 0.97823165, Antimicrobial agents and chemotherapy, 2005, Samonis, George et. al.
Antimicrobial susceptibilities of Campylobacter strains isolated from Finnish subjects infected domestically or from those infected abroad.
score: 0.97822507, Antimicrobial agents and chemotherapy, 2003, Rautelin, Hilpi et. al.
Impact of n-6 polyunsaturated fatty acids on growth of multidrug-resistant Pseudomonas aeruginosa: interactions with amikacin and ceftazidime.
score: 0.97820078, Antimicrobial agents and chemotherapy, 2000, Giamarellos-Bourboulis, E J et. al.
Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate.
score: 0.97816153, Antimicrobial agents and chemotherapy, 2002, Krebs, Fred C et. al.
Galactomannan in piperacillin-tazobactam: how much and to what extent?
score: 0.97792369, Antimicrobial agents and chemotherapy, 2005, Machetti, Marco; Furfaro, Elisa; Viscoli, Claudio
Synthesis of Plaunotol Derivatives and their Antibacterial Activities against Helicobacter pylori
score: 0.9778579, Bioorganic & Medicinal Chemistry, 2001, Tago, Keiko et. al.
Methylcytosine-selective fluorescence quenching by osmium complexation
score: 0.97777232, Bioorganic & Medicinal Chemistry, 2007, Tanaka, Kazuo; Tainaka, Kazuki; Okamoto, Akimitsu
Inhibition of hepatitis C virus (HCV) RNA polymerase by DNA aptamers: mechanism of inhibition of in vitro RNA synthesis and effect on HCV-infected cells.
score: 0.97774338, Antimicrobial agents and chemotherapy, 2008, Bellecave, Pantxika et. al.
Chitosan augments photodynamic inactivation of gram-positive and gram-negative bacteria.
score: 0.9776019, Antimicrobial agents and chemotherapy, 2011, Tsai, Tsuimin et. al.
Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults.
score: 0.97759078, Antimicrobial agents and chemotherapy, 2005, Wertheim, Heiman F L et. al.
Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties
score: 0.97756247, Chemistry Central Journal, 2012, Al-Said, Mansour S; Ghorab, Mostafa M; Nissan, Yassin M
Intrapulmonary pharmacokinetics of linezolid.
score: 0.97751604, Antimicrobial agents and chemotherapy, 2002, Conte, John E et. al.
Comprehensive high-Resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay
score: 0.97743867, Bioorganic & Medicinal Chemistry, 2003, Tse, Winston C.; Ishii, Takahiro; Boger, Dale L.
In vitro activities of garenoxacin and levofloxacin against Chlamydia pneumoniae are not affected by presence of Mycoplasma DNA.
score: 0.97737526, Antimicrobial agents and chemotherapy, 2004, Smith, Raymond P et. al.
Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime.
score: 0.97737521, Antimicrobial agents and chemotherapy, 2002, Ameyama, Satoshi et. al.
Effect of topical liposomes containing paromomycin sulfate in the course of Leishmania major infection in susceptible BALB/c mice.
score: 0.97732716, Antimicrobial agents and chemotherapy, 2009, Jaafari, Mahmoud R et. al.
Integrating conjugative elements as vectors of antibiotic, mercury, and quaternary ammonium compound resistance in marine aquaculture environments.
score: 0.97731716, Antimicrobial agents and chemotherapy, 2012, Rodríguez-Blanco, Arturo; Lemos, Manuel L; Osorio, Carlos R
Pharmacokinetics and renal disposition of polymyxin B in an animal model.
score: 0.97729454, Antimicrobial agents and chemotherapy, 2012, Abdelraouf, Kamilia et. al.
Relation between the molecular electrostatic potential and activity of some FF-MAS related sterol compounds
score: 0.97725397, Bioorganic & Medicinal Chemistry, 2001, Boer, D.R et. al.
Dendrimer-based tumor cell targeting of fibroblast growth factor-1
score: 0.97722385, Bioorganic & Medicinal Chemistry Letters, 2010, Thomas, Thommey P. et. al.
Chimeric RNase H-competent oligonucleotides directed to the HIV-1 Rev response element
score: 0.97720004, Bioorganic & Medicinal Chemistry, 2007, Prater, Chrissy E. et. al.
Stereochemical studies of hexylitaconic acid, an inhibitor of p53–HDM2 interaction
score: 0.97713202, Bioorganic & Medicinal Chemistry Letters, 2009, Nakahashi, Atsufumi et. al.
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine
score: 0.97705822, European Journal of Medicinal Chemistry, 2012, White, Alex W. et. al.
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine
score: 0.97705822, European Journal of Medicinal Chemistry, 2012, White, Alex W. et. al.
Organization of tn2610 containing two transposition modules.
score: 0.97705709, Antimicrobial agents and chemotherapy, 2006, Takaya, Akiko; Watanabe, Masato; Yamamoto, Tomoko
Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducible.
score: 0.97705391, Antimicrobial agents and chemotherapy, 2005, Ambrose, Karita D; Nisbet, Rebecca; Stephens, David S
Evaluation of the invader assay, a linear signal amplification method, for identification of mutations associated with resistance to rifampin and isoniazid in Mycobacterium tuberculosis.
score: 0.97703254, Antimicrobial agents and chemotherapy, 2000, Cooksey, R C et. al.
Biosynthesis of acaterin: Mechanism of the reaction catalyzed by dehydroacaterin reductase
score: 0.97699512, Bioorganic & Medicinal Chemistry, 2006, Nakano, Sayaka et. al.
Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli.
score: 0.97697127, Antimicrobial agents and chemotherapy, 2002, Patrzykat, Aleksander et. al.
Biocatalytic desulfurization of arylsulfonates
score: 0.976949, Bioorganic & Medicinal Chemistry, 1994, Dudley, Matthew W.; Frost, J.W.
Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration.
score: 0.97692008, Antimicrobial agents and chemotherapy, 2006, Marchand, Sandrine et. al.
Synthesis of a key Mycobacterium tuberculosis biosynthetic phosphoinositide intermediate
score: 0.9766292, Bioorganic & Medicinal Chemistry Letters, 2004, Jayaprakash, K.N.; Lu, Jun; Fraser-Reid, Bert
Virtual Screening of Virtual Libraries
score: 0.97656235, Progress in Medicinal Chemistry, 2003, Green, Darren V.S
Virtual Screening of Virtual Libraries
score: 0.97656235, Progress in Medicinal Chemistry, 2003, Green, Darren V.S
Bisacridines with aromatic linking chains. Synthesis, DNA interaction, and antitumor activity
score: 0.97648244, Bioorganic & Medicinal Chemistry, 2004, Lorente, Antonio et. al.
Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives
score: 0.9764431, European Journal of Medicinal Chemistry, 2012, Quiroga, Ezequiel D. et. al.
Optimal meropenem concentrations to treat multidrug-resistant Pseudomonas aeruginosa septic shock.
score: 0.9764004, Antimicrobial agents and chemotherapy, 2012, Taccone, Fabio Silvio et. al.
Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients.
score: 0.97639514, Antimicrobial agents and chemotherapy, 1999, Müller, M et. al.
In vitro activities of 10 antifungal drugs against 508 dermatophyte strains.
score: 0.97638035, Antimicrobial agents and chemotherapy, 2001, Fernández-Torres, B et. al.
Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries
score: 0.97630308, Bioorganic & Medicinal Chemistry Letters, 2000, Pirrung, Michael C; Park, Kaapjoo
Chronic respiratory infections by mucoid carbapenemase-producing Pseudomonas aeruginosa strains, a new potential public health problem.
score: 0.9762847, Antimicrobial agents and chemotherapy, 2008, Juan, Carlos et. al.
Artificial receptors involved in enolization and p K a shifts
score: 0.97627835, Bioorganic & Medicinal Chemistry, 2001, Snowden, Timothy S.; Bisson, Adrian P.; Anslyn, Eric V.
The triphosphate of β- d-4′- C-ethynyl-2′,3′-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase
score: 0.97620843, Bioorganic & Medicinal Chemistry, 2007, Siddiqui, Maqbool A.; Marquez, Victor E.
Efficient Synthesis of Guanfu Base G via Highly Regioselective Lipase-catalyzed Acylation in Non-aqueous Phase
score: 0.9761999, Bioorganic & Medicinal Chemistry Letters, 2012, Xia, Ye; Liu, Ji-Hua; Liu, Jing-Han; Yu, Bo-Yang
Silencing of glycopeptide resistance in Enterococcus faecalis BM4405 by novobiocin.
score: 0.97617936, Antimicrobial agents and chemotherapy, 2005, Patiño, Lorena Abadía et. al.
Use of mutator strains for characterization of novel antimicrobial agents.
score: 0.97616215, Antimicrobial agents and chemotherapy, 2001, O'Neill, A J; Chopra, I
16S rRNA mutation-mediated tetracycline resistance in Helicobacter pylori.
score: 0.97613442, Antimicrobial agents and chemotherapy, 2002, Gerrits, Monique M et. al.
In Vitro Analyses of the Effects of Heparin and Parabens on Candida albicans Biofilms and Planktonic Cells.
score: 0.97613108, Antimicrobial agents and chemotherapy, 2012, Miceli, Marisa H et. al.
Should we use N-acetyltransferase type 2 genotyping to personalize isoniazid doses?
score: 0.97610767, Antimicrobial agents and chemotherapy, 2005, Kinzig-Schippers, Martina et. al.
Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats.
score: 0.97609579, Antimicrobial agents and chemotherapy, 2002, Solbrig, Marylou V et. al.
QSAR study on toxicity to aqueous organisms using the PI index
score: 0.97608883, Bioorganic & Medicinal Chemistry, 2002, Khadikar, Padmakar V.; Phadnis, Anjani; Shrivastava, Anjali
Pulsed-exposure and postantibiotic leukocyte enhancement effects of amikacin, clarithromycin, clofazimine, and rifampin against intracellular Mycobacterium avium.
score: 0.97604897, Antimicrobial agents and chemotherapy, 1998, Horgen, L; Jerome, A; Rastogi, N
Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs
score: 0.97600981, Bioorganic & Medicinal Chemistry Letters, 2006, Granier, Sébastien et. al.
Identifying patients harboring extended-spectrum-beta-lactamase-producing Enterobacteriaceae on hospital admission: derivation and validation of a scoring system.
score: 0.97597647, Antimicrobial agents and chemotherapy, 2011, Tumbarello, Mario et. al.
Horizontal transfer of iturin A operon, itu, to Bacillus subtilis 168 and conversion into an iturin A producer.
score: 0.97596441, Antimicrobial agents and chemotherapy, 2005, Tsuge, Kenji et. al.
Investigation of the interaction between amodiaquine and human serum albumin by fluorescence spectroscopy and molecular modeling
score: 0.9759614, European Journal of Medicinal Chemistry, 2012, Samari, Fayezeh et. al.
Compartmental pharmacokinetics and tissue distribution of multilamellar liposomal nystatin in rabbits.
score: 0.97593181, Antimicrobial agents and chemotherapy, 2000, Groll, A H et. al.
Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate
score: 0.97588756, Bioorganic & Medicinal Chemistry Letters, 2004, Jackson, Henry L et. al.
Pharmacodynamics of the antibacterial effect of and emergence of resistance to doripenem in Pseudomonas aeruginosa and Acinetobacter baumannii in an in vitro pharmacokinetic model.
score: 0.97587345, Antimicrobial agents and chemotherapy, 2012, Bowker, Karen E et. al.
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
score: 0.97579633, Nature chemical biology, 2010, Kwiatkowski, Nicholas et. al.
Chemoprophylaxis of influenza A virus infections, with single doses of zanamivir, demonstrates that zanamivir is cleared slowly from the respiratory tract.
score: 0.97569893, Antimicrobial agents and chemotherapy, 1999, Fenton, R J et. al.
Relationship of carbapenem restriction in 22 university teaching hospitals to carbapenem use and carbapenem-resistant Pseudomonas aeruginosa.
score: 0.97565649, Antimicrobial agents and chemotherapy, 2009, Pakyz, Amy L; Oinonen, Michael; Polk, Ronald E
Non-peptidic inhibitors of human neutrophil elastase: The design and synthesis of sulfonanilide-containing inhibitors
score: 0.97560461, Bioorganic & Medicinal Chemistry, 1996, Imaki, Katsuhiro et. al.
In vitro activities of Y-688, a new 7-substituted fluoroquinolone, against anaerobic bacteria.
score: 0.97548975, Antimicrobial agents and chemotherapy, 1998, MacGowan, A P et. al.
Use of confocal microscopy to analyze the rate of vancomycin penetration through Staphylococcus aureus biofilms.
score: 0.97545085, Antimicrobial agents and chemotherapy, 2005, Jefferson, Kimberly K; Goldmann, Donald A; Pier, Gerald B
Novel pH-Sensitive cationic lipids with linear ortho ester linkers for gene delivery
score: 0.97542134, European Journal of Medicinal Chemistry, 2012, Chen, Haigang et. al.
Use of the hepatitis B virus recombinant baculovirus-HepG2 system to study the effects of (-)-beta-2',3'-dideoxy-3'-thiacytidine on replication of hepatitis B virus and accumulation of covalently closed circular DNA.
score: 0.97536891, Antimicrobial agents and chemotherapy, 1999, Delaney, W E; Miller, T G; Isom, H C
The abasic site as a target for generation of locally multiply damaged sites
score: 0.97534395, Bioorganic & Medicinal Chemistry Letters, 2000, Martelli, Alain et. al.
Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi
score: 0.97523522, Bioorganic & Medicinal Chemistry, 2001, Loukaci, Ali et. al.
Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae.
score: 0.97514694, Antimicrobial agents and chemotherapy, 2000, Capobianco, J O et. al.
Synergy of histone-derived peptides of coho salmon with lysozyme and flounder pleurocidin.
score: 0.97502411, Antimicrobial agents and chemotherapy, 2001, Patrzykat, A; Zhang, L; Mendoza, V; Iwama, G K; Hancock, R E
Covalent protein–oligonucleotide conjugates by copper-free click reaction
score: 0.97497743, Bioorganic & Medicinal Chemistry, 2012, Khatwani, Santoshkumar L. et. al.
Covalent protein–oligonucleotide conjugates by copper-free click reaction
score: 0.97497743, Bioorganic & Medicinal Chemistry, 2012, Khatwani, Santoshkumar L. et. al.
Inhibition of HIV-1 Tat-TAR interaction by diphenylfuran derivatives: effects of the terminal basic side chains
score: 0.9748139, Bioorganic & Medicinal Chemistry, 1999, Gelus, Nathalie et. al.
Synthesis and biological properties of chemically modified siRNAs bearing 1-deoxy-d-ribofuranose in their 3′-overhang region
score: 0.97479795, Bioorganic & Medicinal Chemistry Letters, 2012, Taniho, Kazumi et. al.
Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: A chemoenzymatic route to sulforaphane
score: 0.97467012, Bioorganic & Medicinal Chemistry Letters, 1999, Iori, R. et. al.
Identification of a new anti-diabetic agent by combining VOSO 4 and vitamin E in a single molecule: Studies on its spectral, thermal and pharmacological properties
score: 0.9746663, European Journal of Medicinal Chemistry, 2010, Refat, Moamen S.; El-Shazly, Samir A.
Identification of a new anti-diabetic agent by combining VOSO 4 and vitamin E in a single molecule: Studies on its spectral, thermal and pharmacological properties
score: 0.9746663, European Journal of Medicinal Chemistry, 2010, Refat, Moamen S.; El-Shazly, Samir A.
Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children.
score: 0.97458713, Antimicrobial agents and chemotherapy, 2010, Walsh, Thomas J et. al.
Molecular characterization of resistance to macrolides in Bartonella henselae.
score: 0.97450501, Antimicrobial agents and chemotherapy, 2006, Biswas, Silpak; Raoult, Didier; Rolain, Jean-Marc
In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain
score: 0.97441663, European Journal of Medicinal Chemistry, 2006, Badhan, Raj; Penny, Jeffrey
The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
score: 0.97435668, Bioorganic & Medicinal Chemistry Letters, 2006, Tuntiwechapikul, Wirote et. al.
Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro
score: 0.97424016, Bioorganic & Medicinal Chemistry, 2005, Xing, Ronge et. al.
Accumulation of norfloxacin by Bacteroides fragilis.
score: 0.9742388, Antimicrobial agents and chemotherapy, 2000, Ricci, V; Piddock, L J
Vancomycin resistance plasmid in Enterococcus faecalis that encodes sensitivity to a sex pheromone also produced by Staphylococcus aureus.
score: 0.97411132, Antimicrobial agents and chemotherapy, 2001, Showsh, S A; De Boever, E H; Clewell, D B
Development of potential anticancer agents that target the telomere sequence
score: 0.97388936, Bioorganic & Medicinal Chemistry Letters, 2010, Park, Myunji; Bruice, Thomas C.
Solid-phase synthesis of oligomeric deoxynucleic-thiourea (DNT) and deoxynucleic S-methylthiourea (DNmt): a neutral/polycationic analogue of DNA
score: 0.97385106, Bioorganic & Medicinal Chemistry Letters, 2000, Arya, Dev P; Bruice, Thomas C
Radiolabeling of RGD peptide and preliminary biological evaluation in mice bearing U87MG tumors
score: 0.97377574, Bioorganic & Medicinal Chemistry, 2012, Li, Jianbo et. al.
Radiolabeling of RGD peptide and preliminary biological evaluation in mice bearing U87MG tumors
score: 0.97377574, Bioorganic & Medicinal Chemistry, 2012, Li, Jianbo et. al.
Radiolabeling of RGD peptide and preliminary biological evaluation in mice bearing U87MG tumors
score: 0.97377574, Bioorganic & Medicinal Chemistry, 2012, Li, Jianbo et. al.
Comparative effectiveness of linezolid and vancomycin among a national cohort of patients infected with methicillin-resistant Staphylococcus aureus.
score: 0.97374403, Antimicrobial agents and chemotherapy, 2010, Caffrey, Aisling R; Quilliam, Brian J; LaPlante, Kerry L
The treatment response of chronically hepatitis C virus-infected patients depends on interferon concentration but not on interferon gene expression in peripheral blood mononuclear cells.
score: 0.9737229, Antimicrobial agents and chemotherapy, 2012, François, Catherine et. al.
Effects of fluconazole and clarithromycin on rifabutin and 25-O-desacetylrifabutin pharmacokinetics.
score: 0.97372157, Antimicrobial agents and chemotherapy, 2000, Jordan, M K et. al.
Steady-state plasma and bronchopulmonary concentrations of intravenous levofloxacin and azithromycin in healthy adults.
score: 0.97362001, Antimicrobial agents and chemotherapy, 2003, Rodvold, Keith A; Danziger, Larry H; Gotfried, Mark H
Pharmacokinetic assessment of nevirapine and metabolites in human immunodeficiency virus type 1-infected patients with hepatic fibrosis.
score: 0.97360926, Antimicrobial agents and chemotherapy, 2009, Cammett, Anna Maria et. al.
Iridoid glucosides from Nyctanthes arbortristis results in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite
score: 0.97359235, European Journal of Medicinal Chemistry, 2012, Shukla, Anil Kumar; Patra, Sanjukta; Dubey, Vikash Kumar
Intrinsic epidemicity of Streptococcus pneumoniae depends on strain serotype and antibiotic susceptibility pattern.
score: 0.97357905, Antimicrobial agents and chemotherapy, 2011, Domenech de Cellès, Matthieu et. al.
Class 1 Integrons in Salmonella Strains causing traveler's diarrhea.
score: 0.97355686, Antimicrobial agents and chemotherapy, 2006, Cabrera, Roberto et. al.
QSAR studies of HIV-1 integrase inhibition
score: 0.97336533, Bioorganic & Medicinal Chemistry, 2002, Yuan, Hongbin; Parrill, Abby L
Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG)
score: 0.97334777, Bioorganic & Medicinal Chemistry, 2005, Temperini, Claudia et. al.
The adenine derivative of α- l-LNA (α- l- ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and α- l-LNA complementary sequences
score: 0.97333964, Bioorganic & Medicinal Chemistry Letters, 2001, Håkansson, Anders E; Wengel, Jesper
Persistence of Borrelia burgdorferi following antibiotic treatment in mice.
score: 0.97331313, Antimicrobial agents and chemotherapy, 2008, Hodzic, Emir et. al.
Expansion of clonal complex 258 KPC-2-producing Klebsiella pneumoniae in Latin American hospitals: report of the SENTRY Antimicrobial Surveillance Program.
score: 0.97322173, Antimicrobial agents and chemotherapy, 2012, Castanheira, Mariana et. al.
On the nature of the irreversible inhibition of histidine ammonia lyase by cysteine and dioxygen
score: 0.97310459, Bioorganic & Medicinal Chemistry, 1996, Weber, Karlheinz; Rétey, János
Enterocin P causes potassium ion efflux from Enterococcus faecium T136 cells.
score: 0.97305545, Antimicrobial agents and chemotherapy, 2001, Herranz, C et. al.
Accumulation of 3-ketosteroids induced by itraconazole in azole-resistant clinical Candida albicans isolates.
score: 0.97304333, Antimicrobial agents and chemotherapy, 1999, Marichal, P et. al.
Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides
score: 0.97298557, Bioorganic & Medicinal Chemistry, 2007, Bando, Toshikazu et. al.
Concise Synthesis of Ciguatoxin ABC-Ring Fragments and Surface Plasmon Resonance Study of the Interaction of their BSA Conjugates with Monoclonal Antibodies
score: 0.97297282, Bioorganic & Medicinal Chemistry Letters, 2001, Nagumo, Yoko et. al.
Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes.
score: 0.972969, Antimicrobial agents and chemotherapy, 2010, Brenciani, Andrea et. al.
Preclinical safety assessments of UC781 anti-human immunodeficiency virus topical microbicide formulations.
score: 0.97292488, Antimicrobial agents and chemotherapy, 2007, Patton, D L et. al.
Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis.
score: 0.97288837, Antimicrobial agents and chemotherapy, 1998, Collins, L A; Torrero, M N; Franzblau, S G
Hepatitis C RNA–Dependent RNA Polymerase Inhibitors: A Review of Structure–Activity and Resistance Relationships; Different Scaffolds and Mutations
score: 0.97286666, Bioorganic & Medicinal Chemistry, 2012, Mayhoub, Abdelrahman S.
Concise synthesis of Cannabisin G
score: 0.97285324, Bioorganic & Medicinal Chemistry Letters, 2010, Li, Dawei; Li, Wenling; Wang, Qian; Yang, Zhaoqi; Hou, Zijie
Administration of liposomal agents and blood clearance capacity of the mononuclear phagocyte system.
score: 0.9728466, Antimicrobial agents and chemotherapy, 1998, van Etten, E W et. al.
Mutational analysis of metronidazole resistance in Helicobacter pylori.
score: 0.97273268, Antimicrobial agents and chemotherapy, 2005, Moore, Jill M; Salama, Nina R
Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents.
score: 0.97272102, Antimicrobial agents and chemotherapy, 1999, Henry, K W; Cruz, M C; Katiyar, S K; Edlind, T D
Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae.
score: 0.97269727, Antimicrobial agents and chemotherapy, 2006, Takahata, Sho et. al.
Therapeutic drug monitoring of posaconazole in patients with acute myeloid leukemia or myelodysplastic syndrome.
score: 0.97268097, Antimicrobial agents and chemotherapy, 2012, Vaes, M et. al.
A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.
score: 0.97259623, Antimicrobial agents and chemotherapy, 1999, Bozdogan, B et. al.
Single-dose pharmacokinetics of meropenem during continuous venovenous hemofiltration.
score: 0.97258498, Antimicrobial agents and chemotherapy, 1998, Thalhammer, F et. al.
Pharmacokinetics and safety of single oral doses of emtricitabine in human immunodeficiency virus-infected children.
score: 0.97257532, Antimicrobial agents and chemotherapy, 2004, Wang, Laurene H et. al.
Development of a multicomponent kinetic assay of the early enzymes in the Campylobacter jejuni N-linked glycosylation pathway
score: 0.97252619, Bioorganic & Medicinal Chemistry, 2010, Morrison, James P.; Troutman, Jerry M.; Imperiali, Barbara
Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid.
score: 0.97251136, Antimicrobial agents and chemotherapy, 2002, Conte, John E et. al.
Transmission of IncN plasmids carrying blaCTX-M-1 between commensal Escherichia coli in pigs and farm workers.
score: 0.97240628, Antimicrobial agents and chemotherapy, 2009, Moodley, Arshnee; Guardabassi, Luca
Two pharmacodynamic models for assessing the efficacy of amoxicillin-clavulanate against experimental respiratory tract infections caused by strains of Streptococcus pneumoniae.
score: 0.97232473, Antimicrobial agents and chemotherapy, 1999, Woodnutt, G; Berry, V
Pharmacokinetics of meropenem in critically ill patients with acute renal failure treated by continuous hemodiafiltration.
score: 0.9722887, Antimicrobial agents and chemotherapy, 1998, Krueger, W A et. al.
The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs
score: 0.97225247, European Journal of Medicinal Chemistry, 2008, Cheng, Yiyun; Xu, Tongwen
Hyperlactatemia and human immunodeficiency virus infection: lessons from the era of antiretroviral monotherapy.
score: 0.97211646, Antimicrobial agents and chemotherapy, 2002, Chariot, Patrick et. al.
The chemistry and biology of mucin-type O-linked glycosylation
score: 0.97210844, Bioorganic & Medicinal Chemistry, 2005, Hang, Howard C.; Bertozzi, Carolyn R.
In vitro microbicidal activities of cecropin peptides D2A21 and D4E1 and gel formulations containing 0.1 to 2% D2A21 against Chlamydia trachomatis.
score: 0.97204207, Antimicrobial agents and chemotherapy, 2002, Ballweber, L M; Jaynes, J E; Stamm, W E; Lampe, M F
Detection of azithromycin resistance in Treponema pallidum by real-time PCR.
score: 0.97203379, Antimicrobial agents and chemotherapy, 2007, Pandori, Mark W et. al.
Mutations in 23S rRNA account for intrinsic resistance to macrolides in Mycoplasma hominis and Mycoplasma fermentans and for acquired resistance to macrolides in M. hominis.
score: 0.97199294, Antimicrobial agents and chemotherapy, 2002, Pereyre, S et. al.
A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats
score: 0.97199089, Bioorganic & Medicinal Chemistry Letters, 2012, Hagihara, Masaki et. al.
First total synthesis of prasinic acid and its anticancer activity
score: 0.97196111, Bioorganic & Medicinal Chemistry Letters, 2012, Chakor, Narayan et. al.
First total synthesis of prasinic acid and its anticancer activity
score: 0.97196111, Bioorganic & Medicinal Chemistry Letters, 2012, Chakor, Narayan et. al.
PhoQ Mutations Promote Lipid A Modification and Polymyxin Resistance of Pseudomonas aeruginosa Found in Colistin-Treated Cystic Fibrosis Patients.
score: 0.97188574, Antimicrobial agents and chemotherapy, 2011, Miller, Amanda K et. al.
Differential bidirectional transfer of indinavir in the isolated perfused human placenta.
score: 0.97188006, Antimicrobial agents and chemotherapy, 2005, Sudhakaran, Sreeja et. al.
PnuC and the utilization of the nicotinamide riboside analog 3-aminopyridine in Haemophilus influenzae.
score: 0.97186735, Antimicrobial agents and chemotherapy, 2004, Sauer, Elizabeta et. al.
Antioxidant activity of water-soluble chitosan derivatives
score: 0.97180177, Bioorganic & Medicinal Chemistry Letters, 2001, Xie, Wenming; Xu, Peixin; Liu, Qing
Synthesis, electrochemistry, and molluscicidal activity of nitroaromatic compounds: effects of substituents and the role of redox potential
score: 0.97178211, Bioorganic & Medicinal Chemistry, 2001, de Abreu, Fabiane C. et. al.
Impact of antimicrobial dosing regimen on evolution of drug resistance in vivo: fluconazole and Candida albicans.
score: 0.97176165, Antimicrobial agents and chemotherapy, 2006, Andes, D et. al.
Lamivudine resistance in human T-cell leukemia virus type 1 may be due to a polymorphism at codon 118 (V-->I) of the reverse transcriptase.
score: 0.97175533, Antimicrobial agents and chemotherapy, 2003, Toro, Carlos et. al.
Enantioselective syntheses of ( R)- and ( S)-argentilactone and their cytotoxic activities against cancer cell lines
score: 0.97168437, Bioorganic & Medicinal Chemistry, 2004, de Fatima, Ângelo et. al.
Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum β-lactamase from an Escherichia coli O102-ST405 strain.
score: 0.97161706, Antimicrobial agents and chemotherapy, 2011, Billard-Pomares, Typhaine et. al.
Non-imidazole histamine H 3 ligands. Part III. New 4- n-propylpiperazines as non-imidazole histamine H 3-antagonists
score: 0.97160174, European Journal of Medicinal Chemistry, 2005, Walczyński, Krzysztof; Zuiderveld, Obbe P.; Timmerman, Henk
New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents
score: 0.97157555, Bioorganic & Medicinal Chemistry, 2006, Ziakas, George N. et. al.
Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients.
score: 0.9714374, Antimicrobial agents and chemotherapy, 2002, Blandizzi, Corrado et. al.
Synergy, pharmacodynamics, and time-sequenced ultrastructural changes of the interaction between nikkomycin Z and the echinocandin FK463 against Aspergillus fumigatus.
score: 0.9714311, Antimicrobial agents and chemotherapy, 2001, Chiou, C C et. al.
Synthesis of bicyclic biaryls as glucose-6-phosphatase inhibitors
score: 0.97141337, Bioorganic & Medicinal Chemistry, 2004, Farhanullah, et. al.
Effect of antacids and ranitidine on the single-dose pharmacokinetics of fosamprenavir.
score: 0.97133447, Antimicrobial agents and chemotherapy, 2005, Ford, Susan L et. al.
In vitro activities of rifamycin derivatives ABI-1648 (Rifalazil, KRM-1648), ABI-1657, and ABI-1131 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae.
score: 0.97131597, Antimicrobial agents and chemotherapy, 2003, Roblin, Patricia M et. al.
Pharmacokinetics-pharmacodynamics of tigecycline in patients with community-acquired pneumonia.
score: 0.97130134, Antimicrobial agents and chemotherapy, 2012, Rubino, Christopher M et. al.
Chemoenzymatic synthesis of polyprenyl phosphates
score: 0.97115724, Bioorganic & Medicinal Chemistry, 2008, Hartley, Meredith D.; Larkin, Angelyn; Imperiali, Barbara
Irreversibly inhibitory kinetics of 3,5-dihydroxyphenyl decanoate on mushroom ( Agaricus bisporus) tyrosinase
score: 0.9711393, Bioorganic & Medicinal Chemistry, 2005, Qiu, Ling et. al.
Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor.
score: 0.97106619, Antimicrobial agents and chemotherapy, 2011, Neoh, Chin Fen et. al.
Design and Synthesis of Novel Tetra-Peptide Motilin Agonists
score: 0.97103848, Bioorganic & Medicinal Chemistry, 2002, Haramura, Masayuki et. al.
Determination of meropenem penetration into the lung from sparse data.
score: 0.97101688, Antimicrobial agents and chemotherapy, 2011, Kees, Martin G; Lodise, Thomas P; Drusano, G L
Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients.
score: 0.97093506, Antimicrobial agents and chemotherapy, 2003, Marcelin, Anne-Geneviève et. al.
Genetic context and structural diversity of class 1 integrons from human commensal bacteria in a hospital intensive care unit.
score: 0.97089166, Antimicrobial agents and chemotherapy, 2011, Betteridge, Thu et. al.
Effects of peripheral substituents on diastereoselectivity of the fifth ligand-binding to chlorophylls, and nomenclature of the asymmetric axial coordination sites
score: 0.97082142, Bioorganic & Medicinal Chemistry, 2005, Oba, Toru; Tamiaki, Hitoshi
Atomic force microscopy study of the effect of antimicrobial peptides on the cell envelope of Escherichia coli.
score: 0.970712, Antimicrobial agents and chemotherapy, 2005, Meincken, M; Holroyd, D L; Rautenbach, M
ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphaerella graminicola.
score: 0.97063068, Antimicrobial agents and chemotherapy, 2002, Zwiers, Lute-Harm et. al.
Cyanine dye conjugates as probes for live cell imaging
score: 0.97062123, Bioorganic & Medicinal Chemistry Letters, 2007, Carreon, Jay R. et. al.
Synthesis of a cationic pyridoxamine conjugation reagent and application to the mechanistic analysis of an artificial transaminase
score: 0.97058886, Bioorganic & Medicinal Chemistry Letters, 2000, Kuang, Hao et. al.
Human salivary histatin 5 fungicidal action does not induce programmed cell death pathways in Candida albicans.
score: 0.97053769, Antimicrobial agents and chemotherapy, 2004, Wunder, David; Dong, Jin; Baev, Didi; Edgerton, Mira
Local treatment of experimental Pseudomonas aeruginosa osteomyelitis with a biodegradable dilactide polymer releasing ciprofloxacin.
score: 0.97044622, Antimicrobial agents and chemotherapy, 2008, Kanellakopoulou, Kyriaki et. al.
Amino acid substitutions at position 69 of the reverse transcriptase of human immunodeficiency virus type 1 are frequent in zalcitabine-naive antiretroviral-drug-experienced patients.
score: 0.97038736, Antimicrobial agents and chemotherapy, 2002, Montes, Brigitte; Segondy, Michel
Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains.
score: 0.9703315, Antimicrobial agents and chemotherapy, 1998, Breitschwerdt, E B; Hegarty, B C; Hancock, S I
Bactericidal and antiendotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2.
score: 0.97027162, Antimicrobial agents and chemotherapy, 2005, Santamaría, Carlos et. al.
Oligonucleotides containing 7-vinyl-7-deazaguanine as a facile strategy for expanding the functional diversity of DNA
score: 0.97022967, Bioorganic & Medicinal Chemistry Letters, 2002, Okamoto, Akimitsu et. al.
Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study.
score: 0.97019418, Antimicrobial agents and chemotherapy, 1998, Loebstein, R et. al.
Vancomycin resistance: Modeling backbone variants with d-Ala- d-Ala and d-Ala- d-Lac peptides
score: 0.97018904, Bioorganic & Medicinal Chemistry Letters, 2009, Leung, Siegfried S.F. et. al.
Activity of LY333328 combined with gentamicin in vitro and in rabbit experimental endocarditis due to vancomycin-susceptible or -resistant Enterococcus faecalis.
score: 0.97018829, Antimicrobial agents and chemotherapy, 2000, Lefort, A; Saleh-Mghir, A; Garry, L; Carbon, C; Fantin, B
Bactericidal activities of R207910 and other newer antimicrobial agents against Mycobacterium leprae in mice.
score: 0.97011403, Antimicrobial agents and chemotherapy, 2006, Ji, Baohong et. al.
Pharmacokinetics of intravenous piperacillin administration in patients undergoing on-line hemodiafiltration.
score: 0.96999978, Antimicrobial agents and chemotherapy, 2009, Oh, Kook-Hwan et. al.
Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells
score: 0.96998153, Bioorganic & Medicinal Chemistry, 2013, Taka, Thanachai et. al.
Homodimeric SV40 NLS peptide formed by disulfide bond as enhancer for gene delivery
score: 0.96988904, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Bieong-Kil et. al.
Stereoselective synthesis of bioactive natural spiroacetals aculeatins A and B
score: 0.96987877, Bioorganic & Medicinal Chemistry Letters, 2010, Das, Biswanath; Krishnaiah, Martha; Sudhakar, Chithaluri
Antisense oligonucleotides: Efficient synthesis of 2′- O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1 H-tetrazole as coupling activator?
score: 0.96986443, Bioorganic & Medicinal Chemistry, 2006, Wang, Zhiwei et. al.
Eradication of resident bacteria of normal human skin by antimicrobial ointment.
score: 0.96984791, Antimicrobial agents and chemotherapy, 2003, Hendley, J Owen; Ashe, Kathleen M
Chitin Synthases with a Myosin Motor-Like Domain Control the Resistance of Aspergillus fumigatus to Echinocandins.
score: 0.96967347, Antimicrobial agents and chemotherapy, 2012, Jiménez-Ortigosa, Cristina et. al.
Role of lipid II and membrane thickness in the mechanism of action of the lantibiotic bovicin HC5.
score: 0.96960732, Antimicrobial agents and chemotherapy, 2011, Paiva, Aline Dias et. al.
In vitro and in vivo antibacterial activities of L-084, a novel oral carbapenem, against causative organisms of respiratory tract infections.
score: 0.96960319, Antimicrobial agents and chemotherapy, 2001, Miyazaki, S et. al.
Streptococcus pyogenes isolates with high-level macrolide resistance and reduced susceptibility to telithromycin associated with 23S rRNA mutations.
score: 0.96949906, Antimicrobial agents and chemotherapy, 2006, Farrell, David J et. al.
Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy
score: 0.96949436, Bioorganic & Medicinal Chemistry, 2012, Gardner, Christopher R. et. al.
Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy
score: 0.96949436, Bioorganic & Medicinal Chemistry, 2012, Gardner, Christopher R. et. al.
Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy
score: 0.96949436, Bioorganic & Medicinal Chemistry, 2012, Gardner, Christopher R. et. al.
Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines as inhibitors of TNF-α and IL-6
score: 0.96945058, European Journal of Medicinal Chemistry, 2012, Guirado, Antonio et. al.
Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines as inhibitors of TNF-α and IL-6
score: 0.96945058, European Journal of Medicinal Chemistry, 2012, Guirado, Antonio et. al.
DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore
score: 0.96939254, Bioorganic & Medicinal Chemistry, 1999, Boger, Dale L.; Saionz, Kurt W.
Nevirapine plasma exposure affects both durability of viral suppression and selection of nevirapine primary resistance mutations in a clinical setting.
score: 0.96932859, Antimicrobial agents and chemotherapy, 2005, González de Requena, D et. al.
An unusually cold active nitroreductase for prodrug activations
score: 0.96931517, Bioorganic & Medicinal Chemistry, 2012, Çelik, Ayhan; Yetiş, Gülden
An unusually cold active nitroreductase for prodrug activations
score: 0.96931517, Bioorganic & Medicinal Chemistry, 2012, Çelik, Ayhan; Yetiş, Gülden
An unusually cold active nitroreductase for prodrug activations
score: 0.96931517, Bioorganic & Medicinal Chemistry, 2012, Çelik, Ayhan; Yetiş, Gülden
Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists
score: 0.96912653, Bioorganic & Medicinal Chemistry Letters, 2012, Koller, Manuel et. al.
Glu375Gln and Asp225Val mutants: about the nature of the covalent linkages between heme group and apo-Protein in bovine lactoperoxidase
score: 0.96900615, Bioorganic & Medicinal Chemistry Letters, 2001, Suriano, Gianpaolo et. al.
Antimicrobial therapies for Helicobacter pylori infection in gnotobiotic piglets.
score: 0.96899925, Antimicrobial agents and chemotherapy, 1998, Krakowka, S; Eaton, K A; Leunk, R D
An efficient synthesis of methyl tetra- o-hexyl gentiooctaoside, an octaosyl analogue of ANP receptor antagonist HS-142-1
score: 0.96867886, Bioorganic & Medicinal Chemistry, 1996, Qiu, Yi; Nakahara, Yoshiaki; Ogawa, Tomoya
Mutations conferring drug resistance in malaria parasite drug transporters Pgh1 and PfCRT do not affect steady-state vacuolar Ca2+.
score: 0.96867456, Antimicrobial agents and chemotherapy, 2005, Biagini, Giancarlo A et. al.
HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients.
score: 0.96851907, Antimicrobial agents and chemotherapy, 2012, Gonzalez-Serna, Alejandro et. al.
Antibiotic-dependent induction of Pseudomonas putida DOT-T1E TtgABC efflux pump is mediated by the drug binding repressor TtgR.
score: 0.96843181, Antimicrobial agents and chemotherapy, 2003, Terán, Wilson et. al.
Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation.
score: 0.96828969, Nature chemical biology, 2007, Smith, Peter A; Romesberg, Floyd E
Structural alterations in the translational attenuator of constitutively expressed erm(A) genes in Staphylococcus aureus.
score: 0.96827064, Antimicrobial agents and chemotherapy, 2001, Schmitz, F J et. al.
Simultaneous quantitation of intracellular zidovudine and lamivudine triphosphates in human immunodeficiency virus-infected individuals.
score: 0.9682572, Antimicrobial agents and chemotherapy, 2000, Rodriguez, J F et. al.
Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains.
score: 0.96821136, Antimicrobial agents and chemotherapy, 2007, Beer, Ronny et. al.
Synthesis and biological evaluation of 2-(3′-(1 H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine ( S-TBPG), a novel mGlu1 receptor antagonist
score: 0.96818968, Bioorganic & Medicinal Chemistry, 2001, Costantino, Gabriele et. al.
Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells.
score: 0.96816669, Antimicrobial agents and chemotherapy, 2008, Woodhouse, Stephen D et. al.
Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics
score: 0.96814561, Bioorganic & Medicinal Chemistry, 2004, Kruger, Ryan G et. al.
Impact of first-line antifungal agents on the outcomes and costs of candidemia.
score: 0.96812127, Antimicrobial agents and chemotherapy, 2012, Ha, Young Eun et. al.
Synthesis of a fluorescent chemosensor suitable for the imaging of zinc(II) in live cells
score: 0.96810906, Bioorganic & Medicinal Chemistry Letters, 2003, Lim, Nathaniel C. et. al.
Beta-lactamase nomenclature.
score: 0.96807919, Antimicrobial agents and chemotherapy, 2006, Jacoby, George A
Erythromycin and clindamycin resistance in group B streptococcal clinical isolates.
score: 0.96807919, Antimicrobial agents and chemotherapy, 2006, Gygax, Scott E et. al.
Role of attP in integrase-mediated integration of the Shigella resistance locus pathogenicity island of Shigella flexneri.
score: 0.96807919, Antimicrobial agents and chemotherapy, 2004, Turner, Sally A et. al.
Zinc-(II) 2,9,16,23-tetrakis (methoxy) phthalocyanine: Potential photosensitizer for use in photodynamic therapy in vitro
score: 0.96791486, Bioorganic & Medicinal Chemistry, 2007, Yslas, Edith I.; Durantini, Edgardo N.; Rivarola, Viviana A.
A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.
score: 0.9678794, Antimicrobial agents and chemotherapy, 2004, Jost, B Helen et. al.
Virulent Bacteriophages Can Target O104:H4 Enteroaggregative Escherichia coli in the Mouse Intestine.
score: 0.96786182, Antimicrobial agents and chemotherapy, 2012, Maura, Damien et. al.
SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands.
score: 0.96784848, Antimicrobial agents and chemotherapy, 2001, Yuan, M; Hall, L M; Hoogkamp-Korstanje, J; Livermore, D M
Computational study of bindings of HK20 Fab and D5 Fab to HIV-1 gp41
score: 0.96778357, Bioorganic & Medicinal Chemistry Letters, 2012, Hartono, Yossa Dwi et. al.
Pharmacodynamic analysis and clinical trial of amoxicillin sprinkle administered once daily for 7 days compared to penicillin V potassium administered four times daily for 10 days in the treatment of tonsillopharyngitis due to Streptococcus pyogenes in children.
score: 0.96771272, Antimicrobial agents and chemotherapy, 2008, Pichichero, M E et. al.
Structural study of four-stranded quadruplex structures containing 2′-deoxy-8-(propyn-1-yl)adenosine
score: 0.96764588, Bioorganic & Medicinal Chemistry, 2004, Esposito, Veronica et. al.
The 2-aminoglucosamide motif improves cellular uptake and photodynamic activity of tetraphenylporphyrin
score: 0.96759255, European Journal of Medicinal Chemistry, 2005, Di Stasio, Benoît et. al.
Rapid Killing of Acinetobacter baumannii by Polymyxins Is Mediated by a Hydroxyl Radical Death Pathway.
score: 0.96755617, Antimicrobial agents and chemotherapy, 2012, Sampson, Timothy R et. al.
Compound efflux in Helicobacter pylori.
score: 0.96748854, Antimicrobial agents and chemotherapy, 2005, Kutschke, Amy; de Jonge, Boudewijn L M
8-Azapurines as new inhibitors of cyclin-dependent kinases
score: 0.96741967, Bioorganic & Medicinal Chemistry, 2005, Havlicek, Libor et. al.
Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.
score: 0.96737715, Antimicrobial agents and chemotherapy, 2005, Yonezawa, Hideo; Kuramitsu, Howard K
Polysorbate 80 inhibition of Pseudomonas aeruginosa biofilm formation and its cleavage by the secreted lipase LipA.
score: 0.96732076, Antimicrobial agents and chemotherapy, 2009, Toutain-Kidd, Christine M et. al.
Enterococci with glycopeptide resistance in turkeys, turkey farmers, turkey slaughterers, and (sub)urban residents in the south of The Netherlands: evidence for transmission of vancomycin resistance from animals to humans?
score: 0.96724632, Antimicrobial agents and chemotherapy, 1999, Stobberingh, E et. al.
Efficacy of voriconazole in treatment of systemic scedosporiosis in neutropenic mice.
score: 0.96721327, Antimicrobial agents and chemotherapy, 2003, Capilla, Javier et. al.
Synthesis, physicochemical investigation and cytotoxic activity of new Pt(II) complexes with hydantoin ligands
score: 0.9670926, European Journal of Medicinal Chemistry, 2003, Bakalova, Adriana et. al.
Efficient synthesis and evaluation of bimodal ligand NETA
score: 0.96702727, Bioorganic & Medicinal Chemistry Letters, 2008, Chong, Hyun-Soon et. al.
Use of the microbial growth curve in postantibiotic effect studies of Legionella pneumophila.
score: 0.96701992, Antimicrobial agents and chemotherapy, 2003, Smith, Raymond P et. al.
Metals in anticancer therapy: Copper(II) complexes as inhibitors of the 20S proteasome
score: 0.9668698, European Journal of Medicinal Chemistry, 2009, Hindo, Sarmad Sahiel et. al.
Minutissamides E–L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp.
score: 0.96684961, Bioorganic & Medicinal Chemistry, 2012, Kang, Hahk-Soo et. al.
Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modeling
score: 0.96677236, Bioorganic & Medicinal Chemistry, 2005, Zheng, Lei et. al.
Penetration of colistin into cerebrospinal fluid.
score: 0.96671368, Antimicrobial agents and chemotherapy, 2009, Markantonis, S L et. al.
PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin.
score: 0.96657026, Antimicrobial agents and chemotherapy, 2012, Piedade, Rita et. al.
Comparison of the effects of deferiprone versus deferoxamine on growth and virulence of Yersinia enterocolitica.
score: 0.96656265, Antimicrobial agents and chemotherapy, 2002, Lesic, Biliana; Foulon, Jeannine; Carniel, Elisabeth
Analysis of bla(SHV) codon 238 and 240 allele mixtures using Sybr green high-resolution melting analysis.
score: 0.96650391, Antimicrobial agents and chemotherapy, 2009, Andersson, Patiyan et. al.
Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms.
score: 0.96643878, Antimicrobial agents and chemotherapy, 2004, Hamamoto, Hiroshi et. al.
Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages.
score: 0.96639957, Antimicrobial agents and chemotherapy, 2004, Van Bambeke, Françoise et. al.
Safety and single-dose pharmacokinetics of abacavir (1592U89) in human immunodeficiency virus type 1-infected children.
score: 0.96634398, Antimicrobial agents and chemotherapy, 1999, Hughes, W et. al.
Comparative evaluation of NCCLS M27-A and EUCAST broth microdilution procedures for antifungal susceptibility testing of candida species.
score: 0.96630802, Antimicrobial agents and chemotherapy, 2002, Cuenca-Estrella, Manuel et. al.
pEl1573 Carrying blaIMP-4, from Sydney, Australia, Is Closely Related to Other IncL/M Plasmids.
score: 0.96629765, Antimicrobial agents and chemotherapy, 2012, Partridge, Sally R et. al.
Genetic Contexts of blaNDM-1.
score: 0.96629765, Antimicrobial agents and chemotherapy, 2012, Partridge, Sally R; Iredell, Jonathan R
Homology models of the cannabinoid CB1 and CB2 receptors. A docking analysis study
score: 0.96626146, European Journal of Medicinal Chemistry, 2005, Montero, Cristina et. al.
Indinavir-fluconazole interaction.
score: 0.96621185, Antimicrobial agents and chemotherapy, 1999, Bellibas, S E
Synthesis of a netropsin conjugate of a water-soluble epi-quinocarcin analogue: the importance of stereochemistry at nitrogen
score: 0.96617662, Bioorganic & Medicinal Chemistry, 2000, Herberich, Brad; Scott, Jack D.; Williams, Robert M.
Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts.
score: 0.96608988, Antimicrobial agents and chemotherapy, 2008, Adonizio, Allison; Kong, Kok-Fai; Mathee, Kalai
Molecular imaging of hydrogen peroxide produced for cell signaling.
score: 0.96603307, Nature chemical biology, 2007, Miller, Evan W et. al.
Interaction of cromolyn sodium with human serum albumin: A fluorescence quenching study
score: 0.96603168, Bioorganic & Medicinal Chemistry, 2005, Hu, Yan-Jun; Liu, Yi; Pi, Zhen-Bang; Qu, Song-Sheng
Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus.
score: 0.96599739, Antimicrobial agents and chemotherapy, 2005, Koort, Jyri K et. al.
Alterations in penicillin-binding protein 1A confer resistance to beta-lactam antibiotics in Helicobacter pylori.
score: 0.96595256, Antimicrobial agents and chemotherapy, 2002, Gerrits, M M et. al.
Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners
score: 0.96584529, Bioorganic & Medicinal Chemistry Letters, 2005, Hilton, S.T. et. al.
CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1.
score: 0.96574871, Antimicrobial agents and chemotherapy, 2004, Chen, Chia-Geun et. al.
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase.
score: 0.96569551, Antimicrobial agents and chemotherapy, 2005, Parikh, Urvi M et. al.
Synthesis and analgesic evaluation of some 5-[β-(10-phenothiazinyl)ethyl]-1-(acyl)-1,2,3,4-tetrazoles
score: 0.96560435, European Journal of Medicinal Chemistry, 2004, Rajasekaran, A; Thampi, P.P
Effect of the hepatitis C virus protease inhibitor telaprevir on the pharmacokinetics of amlodipine and atorvastatin.
score: 0.96553798, Antimicrobial agents and chemotherapy, 2011, Lee, Jee Eun et. al.
Positive impact of HIV-1 gag cleavage site mutations on the virological response to darunavir boosted with ritonavir.
score: 0.96553648, Antimicrobial agents and chemotherapy, 2011, Larrouy, Lucile et. al.
Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli.
score: 0.96551308, Antimicrobial agents and chemotherapy, 2003, Oberparleiter, Christoph et. al.
Synthesis and antimicrobial study of novel heterocyclic compounds from hydroxybenzophenones
score: 0.96550851, European Journal of Medicinal Chemistry, 2005, Khanum, Shaukath A. et. al.
Mosaic structure of p1658/97, a 125-kilobase plasmid harboring an active amplicon with the extended-spectrum beta-lactamase gene blaSHV-5.
score: 0.96549106, Antimicrobial agents and chemotherapy, 2007, Zienkiewicz, M et. al.
Syntheses and studies of multiwarhead siderophore-5-fluorouridine conjugates
score: 0.96541916, Bioorganic & Medicinal Chemistry, 1999, Lu, Yong; Miller, Marvin J
Effects of organic anion, organic cation, and dipeptide transport inhibitors on cefdinir in the isolated perfused rat kidney.
score: 0.96534272, Antimicrobial agents and chemotherapy, 2003, Lepsy, Christopher S et. al.
Synthesis and antiplatelet activity of phenyl quinolones
score: 0.96528969, Bioorganic & Medicinal Chemistry, 1998, Huang, Li-Jiau et. al.
Cholesterol enhances Helicobacter pylori resistance to antibiotics and LL-37.
score: 0.96520355, Antimicrobial agents and chemotherapy, 2011, McGee, David J et. al.
Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells
score: 0.96510353, Bioorganic & Medicinal Chemistry Letters, 2012, Oishi, Tohru et. al.
Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells
score: 0.96510353, Bioorganic & Medicinal Chemistry Letters, 2012, Oishi, Tohru et. al.
Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells
score: 0.96510353, Bioorganic & Medicinal Chemistry Letters, 2012, Oishi, Tohru et. al.
Determination of the phamacophore of penclomedine, a clinically-evaluated antitumor pyridine derivative
score: 0.96509782, Bioorganic & Medicinal Chemistry, 2002, Tiwari, Anita; Waud, William R; Struck, Robert F
Safety and pharmacokinetics of single intravenous dose of MGAWN1, a novel monoclonal antibody to West Nile virus.
score: 0.96508666, Antimicrobial agents and chemotherapy, 2010, Beigel, John H et. al.
In vitro activities of Garenoxacin (BMS 284756) against 108 clinical isolates of Gardnerella vaginalis.
score: 0.96508366, Antimicrobial agents and chemotherapy, 2002, Goldstein, Ellie J C et. al.
Conformational and SAR analysis of NAALADase and PSMA inhibitors
score: 0.96507772, Bioorganic & Medicinal Chemistry, 2003, Jayne Oliver, A et. al.
[ 11C]Choline as a PET biomarker for assessment of prostate cancer tumor models
score: 0.96502907, Bioorganic & Medicinal Chemistry, 2004, Zheng, Qi-Huang et. al.
Synthesis and spectroscopic studies of biologically active compounds derived from oxalyldihydrazide and benzil, and their Cr(III), Fe(III) and Mn(III) complexes
score: 0.96500149, European Journal of Medicinal Chemistry, 2009, Singh, D.P.; Kumar, Ramesh; Singh, Jitender
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s
score: 0.96495314, Bioorganic & Medicinal Chemistry, 2004, Irie, Kazuhiro et. al.
Itraconazole oral solution for primary prophylaxis of fungal infections in patients with hematological malignancy and profound neutropenia: a randomized, double-blind, double-placebo, multicenter trial comparing itraconazole and amphotericin B.
score: 0.96492802, Antimicrobial agents and chemotherapy, 2000, Harousseau, J L et. al.
Cancer preventive agents. Part 1: Chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds
score: 0.96490118, Bioorganic & Medicinal Chemistry, 2005, Sakurai, Nobuko et. al.
4-Phenylbutanoyl-2( S)-acylpyrrolidines and 4-phenylbutanoyl- l-prolyl-2( S)-acylpyrrolidines as prolyl oligopeptidase inhibitors
score: 0.96483021, Bioorganic & Medicinal Chemistry, 2002, Wallén, Erik A.A et. al.
Development and optimization of a useful assay for determining Hsp90’s inherent ATPase activity
score: 0.96480534, Bioorganic & Medicinal Chemistry, 2006, Avila, Christopher; Kornilayev, Boris A.; Blagg, Brian S.J.
Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus.
score: 0.9647992, Antimicrobial agents and chemotherapy, 2000, Kaatz, G W et. al.
Piperacillin-tazobactam penetration into human pancreatic juice.
score: 0.9647138, Antimicrobial agents and chemotherapy, 2008, Bertazzoni Minelli, Elisa et. al.
A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure.
score: 0.96471198, Antimicrobial agents and chemotherapy, 2009, Zong, Zhiyong; Partridge, Sally R; Iredell, Jonathan R
1,4-Dihydroxyxanthone modulates the adhesive property of endothelial cells by inhibiting intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin
score: 0.9646889, Bioorganic & Medicinal Chemistry, 2004, Madan, Babita et. al.
In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues
score: 0.96464896, Bioorganic & Medicinal Chemistry, 2002, Feldman, Ken S et. al.
Randomized, double-blind trial of an antibiotic-lock technique for prevention of gram-positive central venous catheter-related infection in neutropenic patients with cancer.
score: 0.96446755, Antimicrobial agents and chemotherapy, 1999, Carratalà, J et. al.
Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells
score: 0.96439887, Bioorganic & Medicinal Chemistry, 2012, Asami, Yukihiro et. al.
Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells
score: 0.96439887, Bioorganic & Medicinal Chemistry, 2012, Asami, Yukihiro et. al.
Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells
score: 0.96439887, Bioorganic & Medicinal Chemistry, 2012, Asami, Yukihiro et. al.
Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues
score: 0.96439096, Bioorganic & Medicinal Chemistry, 2008, Seio, Kohji et. al.
Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.
score: 0.96435777, Antimicrobial agents and chemotherapy, 2011, Li, Hui; Luo, Yi-Feng; Blackwell, Timothy S; Xie, Can-Mao
The contribution of the methyl groups on thymine bases to binding specificity and affinity by alanine-rich mutants of the bZIP motif
score: 0.96413307, Bioorganic & Medicinal Chemistry, 2001, Kise, Kenneth J.; Shin, Jumi A.
Identification of optimal renal dosage adjustments for traditional and extended-infusion piperacillin-tazobactam dosing regimens in hospitalized patients.
score: 0.96402503, Antimicrobial agents and chemotherapy, 2010, Patel, N; Scheetz, M H; Drusano, G L; Lodise, T P
In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis.
score: 0.96400394, Antimicrobial agents and chemotherapy, 2011, Küster, Tatiana et. al.
Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 3: Imidazoles
score: 0.963906, Bioorganic & Medicinal Chemistry, 2013, Lamberth, Clemens et. al.
Synthesis of novel (2 R,4 R)- and (2 S,4 S)- iso dideoxynucleosides with exocyclic methylene as potential antiviral agents 1
score: 0.96366805, Bioorganic & Medicinal Chemistry, 2002, Yoo, Su Jeong et. al.
Diversity of the early step of the futalosine pathway.
score: 0.9635611, Antimicrobial agents and chemotherapy, 2011, Arakawa, Chisato et. al.
Dynamics of mutator and antibiotic-resistant populations in a pharmacokinetic/pharmacodynamic model of Pseudomonas aeruginosa biofilm treatment.
score: 0.96354939, Antimicrobial agents and chemotherapy, 2011, Macià, María D et. al.
Evaluation of 18F-labeled acetylcholinesterase substrates as PET radiotracers
score: 0.96335715, Bioorganic & Medicinal Chemistry, 2005, Shao, Xia et. al.
AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN.
score: 0.96335055, Antimicrobial agents and chemotherapy, 2007, Serrano-Gómez, Diego et. al.
A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori.
score: 0.9633395, Antimicrobial agents and chemotherapy, 2000, Tsutsui, N et. al.
Nonbonded bivalence approach to cell-permeable molecules that target DNA sequences
score: 0.96332351, Bioorganic & Medicinal Chemistry, 2004, Pang, Yuan-Ping
Pharmacokinetics of clinafloxacin after single and multiple doses.
score: 0.96322308, Antimicrobial agents and chemotherapy, 2001, Randinitis, E J; Brodfuehrer, J I; Eiseman, I; Vassos, A B
A case of daptomycin-induced immune thrombocytopenia.
score: 0.96311806, Antimicrobial agents and chemotherapy, 2012, Grégoire, Charles et. al.
Novel radiosynthesis of PET HSV-tk gene reporter probes [ 18F]FHPG and [ 18F]FHBG employing dual Sep-Pak SPE techniques
score: 0.96308727, Bioorganic & Medicinal Chemistry Letters, 2003, Wang, Ji-Quan et. al.
Increase of the M phenotype among erythromycin-resistant Streptococcus pneumoniae isolates from Spain related to the serotype 14 variant of the Spain9V-3 clone.
score: 0.96301488, Antimicrobial agents and chemotherapy, 2006, Ardanuy, C; Fenoll, A; Berrón, S; Calatayud, L; Liñares, J
Binding of an aptamer to the N-terminal fragment of VCAM-1
score: 0.96299151, Bioorganic & Medicinal Chemistry Letters, 2007, Chauveau, Fabien et. al.
Establishing criteria for assessment of efficacy of antimicrobial agents in acute otitis media.
score: 0.96290589, Antimicrobial agents and chemotherapy, 2000, Erhardt, W; Murphy, M; Knirsch, C
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein.
score: 0.96284803, Nature chemical biology, 2011, Woods, Lucy A et. al.
Synthesis of vanillin ethers from 4-(bromomethyl) coumarins as anti-inflammatory agents
score: 0.96280328, European Journal of Medicinal Chemistry, 2003, Ghate, Manjunath et. al.
Neuronal nicotinic receptors and epilepsy, from genes to possible therapeutic compounds
score: 0.96274164, Bioorganic & Medicinal Chemistry Letters, 2004, Hogg, Ronald C.; Bertrand, Daniel
The beta-defensin gallinacin-6 is expressed in the chicken digestive tract and has antimicrobial activity against food-borne pathogens.
score: 0.96274009, Antimicrobial agents and chemotherapy, 2007, van Dijk, Albert et. al.
Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8′-hydroxylase CYP707A with no growth-retardant effect
score: 0.96272361, Bioorganic & Medicinal Chemistry, 2009, Todoroki, Yasushi et. al.
Ocular distribution, spectrum of activity, and in vivo viral neutralization of a fully humanized anti-herpes simplex virus IgG Fab fragment following topical application.
score: 0.96266268, Antimicrobial agents and chemotherapy, 2012, Berdugo, Marianne et. al.
Identification of beta-defensins in human conjunctiva.
score: 0.962535, Antimicrobial agents and chemotherapy, 1998, Hattenbach, L O; Gümbel, H; Kippenberger, S
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.
score: 0.96250935, Antimicrobial agents and chemotherapy, 2002, Martínez-Martínez, Luis et. al.
Association of the endotoxin antagonist E5564 with high-density lipoproteins in vitro: dependence on low-density and triglyceride-rich lipoprotein concentrations.
score: 0.96229489, Antimicrobial agents and chemotherapy, 2003, Wasan, Kishor M et. al.
Pharmacodynamic profile of telithromycin against macrolide- and fluoroquinolone-resistant Streptococcus pneumoniae in a neutropenic mouse thigh model.
score: 0.9622734, Antimicrobial agents and chemotherapy, 2005, Tessier, Pamela R et. al.
Biologically active oligodeoxyribonucleotides—IX. 1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification
score: 0.96226134, Bioorganic & Medicinal Chemistry, 1997, Koizumi, Makoto et. al.
In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus.
score: 0.96221235, Antimicrobial agents and chemotherapy, 2006, Naguleswaran, Arunasalam et. al.
Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides
score: 0.96212583, Bioorganic & Medicinal Chemistry Letters, 2003, Collins, Christopher J. et. al.
Synthesis and bronchodilator activity of new quinazolin derivative
score: 0.96201862, European Journal of Medicinal Chemistry, 2006, Zabeer, A. et. al.
Developing site-Specific immobilization strategies of peptides in a microarray
score: 0.96199693, Bioorganic & Medicinal Chemistry Letters, 2002, Lesaicherre, Marie-Laure et. al.
Inducible, but not constitutive, resistance of gonococci to hydrophobic agents due to the MtrC-MtrD-MtrE efflux pump requires TonB-ExbB-ExbD proteins.
score: 0.96182523, Antimicrobial agents and chemotherapy, 2002, Rouquette-Loughlin, Corinne et. al.
Enantioselective synthesis and biological evaluation of 5- o-carboranyl pyrimidine nucleosides
score: 0.961765, Bioorganic & Medicinal Chemistry, 1999, Mourier, Nicolas S. et. al.
Cyclodextrin-grafted polysaccharides as supramolecular carrier systems for naproxen
score: 0.96173615, Bioorganic & Medicinal Chemistry Letters, 2006, Ramírez, Héctor L. et. al.
Outcomes of patients with melioidosis treated with meropenem.
score: 0.96172828, Antimicrobial agents and chemotherapy, 2004, Cheng, Allen C et. al.
Chloramphenicol-sensitive Escherichia coli strain expressing the chloramphenicol acetyltransferase (cat) gene.
score: 0.96169585, Antimicrobial agents and chemotherapy, 2001, Potrykus, J; Wegrzyn, G
Susceptibility of Klebsiella pneumoniae isolates from intra-abdominal infections and molecular characterization of ertapenem-resistant isolates.
score: 0.96166523, Antimicrobial agents and chemotherapy, 2011, Hawser, Stephen P et. al.
Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine.
score: 0.96165026, Antimicrobial agents and chemotherapy, 1999, Adams, L B et. al.
Anti-Kaposi's sarcoma and antiangiogenic activities of sulfated dextrins.
score: 0.96164462, Antimicrobial agents and chemotherapy, 1999, Thornton, M; Barkley, L; Mason, J C; Shaunak, S
Aerosolized gentamicin reduces the burden of tuberculosis in a murine model.
score: 0.96162416, Antimicrobial agents and chemotherapy, 2012, Roy, Chad J et. al.
Pyrazinone conjugates as potential cephalosporin allergens
score: 0.96158503, Bioorganic & Medicinal Chemistry Letters, 2001, Venemalm, Lennart
Effect of Rifampin on Production of Inflammatory Mediators in HepG2 Liver Epithelial Cells.
score: 0.96158468, Antimicrobial agents and chemotherapy, 2011, Yuhas, Yael; Berent, Eva; Ashkenazi, Shai
Pharmacokinetics and safety of intravenous ceftolozane-tazobactam in healthy adult subjects following single and multiple ascending doses.
score: 0.96154921, Antimicrobial agents and chemotherapy, 2012, Miller, Benjamin et. al.
Anthracene based base-discriminating fluorescent oligonucleotide probes for SNPs typing: Synthesis and photophysical properties
score: 0.96147991, Bioorganic & Medicinal Chemistry, 2008, Saito, Yoshio et. al.
Regeneration of 4-thio-2′-deoxyuridine residues in DNA
score: 0.96144838, Bioorganic & Medicinal Chemistry Letters, 1999, Coleman, Robert S.; Pires, Richard M.
Pharmacokinetics of indinavir at 800, 600, and 400 milligrams administered with ritonavir at 100 milligrams and efavirenz in ethnic chinese patients infected with human immunodeficiency virus.
score: 0.96142636, Antimicrobial agents and chemotherapy, 2004, Lee, Lawrence S et. al.
The Cys607-->Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients.
score: 0.96131727, Antimicrobial agents and chemotherapy, 1998, Baldanti, F et. al.
Novel synthesized aminosteroidal heterocycles intervention for inhibiting iron-induced oxidative stress
score: 0.96120459, European Journal of Medicinal Chemistry, 2005, Elmegeed, Gamal A.; Ahmed, Hanaa H.; Hussein, Jihan S.
High-efficiency generation of antibiotic-resistant strains of Streptococcus pneumoniae by PCR and transformation.
score: 0.96116365, Antimicrobial agents and chemotherapy, 2003, Martín-Galiano, Antonio J; de la Campa, Adela G
Gamma interferon supplementation for melioidosis.
score: 0.96113507, Antimicrobial agents and chemotherapy, 2010, Koh, Gavin C K W; Limmathurotsakul, Direk
Effect of antifungal therapy timing on mortality in cancer patients with candidemia.
score: 0.96113248, Antimicrobial agents and chemotherapy, 2010, Taur, Ying et. al.
Modeling the interaction between FK506 and FKBP12: A mechanism for formation of the calcineurin inhibitory complex
score: 0.96110257, Bioorganic & Medicinal Chemistry, 1997, Ivery, Michael T.G.; Weiler, Larry
Population pharmacokinetic analysis of ceftobiprole for treatment of complicated skin and skin structure infections.
score: 0.96100938, Antimicrobial agents and chemotherapy, 2009, Kimko, Holly et. al.
The synthesis and anti-proliferative effects of β-elemene derivatives with mTOR inhibition activity
score: 0.96099786, Bioorganic & Medicinal Chemistry, 2006, Xu, Liying et. al.
Xenograft model for identifying chemotherapeutic agents against papillomaviruses.
score: 0.96097594, Antimicrobial agents and chemotherapy, 2001, Pawellek, A et. al.
Acquisition of rectal colonization by vancomycin-resistant Enterococcus among intensive care unit patients treated with piperacillin-tazobactam versus those receiving cefepime-containing antibiotic regimens.
score: 0.96096443, Antimicrobial agents and chemotherapy, 2008, Paterson, David L et. al.
Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice.
score: 0.96090894, Antimicrobial agents and chemotherapy, 2007, Lewis, Russell E et. al.
Saturability of granulocyte kill of Pseudomonas aeruginosa in a murine model of pneumonia.
score: 0.96077175, Antimicrobial agents and chemotherapy, 2011, Drusano, G L et. al.
Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats.
score: 0.96073222, Antimicrobial agents and chemotherapy, 2001, Ando, H et. al.
Blocking the receptor for interleukin 10 protects mice from lethal listeriosis.
score: 0.96069581, Antimicrobial agents and chemotherapy, 2001, Silva, R A; Appelberg, R
Aminoglycoside use in intensive care units and aminoglycoside nephrotoxicity. Comment letter 1.
score: 0.9606607, Antimicrobial agents and chemotherapy, 2010, Pogue, Jason M; Potoski, Brian A; Kaye, Keith S
Aminoglycoside use in intensive care units and aminoglycoside nephrotoxicity. Comment letter 2.
score: 0.9606607, Antimicrobial agents and chemotherapy, 2010, Peloquin, Charles
A simple, solid-phase binding assay for the nuclear import receptor karyopherin α. Part 1: direct binding
score: 0.96059134, Bioorganic & Medicinal Chemistry Letters, 2000, Connolly, Michael D. et. al.
Structure–activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X 1 receptor antagonist
score: 0.96054952, European Journal of Medicinal Chemistry, 2004, Kassack, Matthias U et. al.
High rates of fecal carriage of nonenterococcal vanB in both children and adults.
score: 0.9604777, Antimicrobial agents and chemotherapy, 2008, Graham, M et. al.
Intrapulmonary pharmacokinetics and pharmacodynamics of itraconazole and 14-hydroxyitraconazole at steady state.
score: 0.9604688, Antimicrobial agents and chemotherapy, 2004, Conte, John E et. al.
Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase.
score: 0.9604246, Antimicrobial agents and chemotherapy, 2010, Karakama, Yuko et. al.
A possible prebiotic synthesis of purine, adenine, cytosine, and 4(3H)-pyrimidinone from formamide
score: 0.96029526, Bioorganic & Medicinal Chemistry, 2001, Saladino, Raffaele et. al.
Pharmacokinetics and efficacies of liposomal and conventional formulations of tobramycin after intratracheal administration in rats with pulmonary Burkholderia cepacia infection.
score: 0.96029476, Antimicrobial agents and chemotherapy, 2002, Marier, Jean-Francois; Lavigne, Jean; Ducharme, Murray P
aph(3')-IIb, a gene encoding an aminoglycoside-modifying enzyme, is under the positive control of surrogate regulator HpaA.
score: 0.96020932, Antimicrobial agents and chemotherapy, 2003, Zeng, Lin; Jin, Shouguang
In vitro and in vivo evaluations of the activities of lauric acid monoester formulations against Staphylococcus aureus.
score: 0.96016763, Antimicrobial agents and chemotherapy, 2005, Rouse, Mark S et. al.
Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists
score: 0.96012089, Bioorganic & Medicinal Chemistry, 2006, Yasuhara, Akito et. al.
Synthesis, crystal structure, DNA interaction and antioxidant activities of two novel water-soluble Cu(2+) complexes derivated from 2-oxo-quinoline-3-carbaldehyde Schiff-bases
score: 0.95984355, European Journal of Medicinal Chemistry, 2009, Liu, Zeng-Chen et. al.
Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2.
score: 0.95979194, Antimicrobial agents and chemotherapy, 2005, Razonable, Raymund R et. al.
Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets
score: 0.95972263, Bioorganic & Medicinal Chemistry, 2003, Villar, Rosa M et. al.
Efficacy of bacteriophage therapy in experimental sepsis and meningitis caused by a clone O25b:H4-ST131 Escherichia coli strain producing CTX-M-15.
score: 0.95966808, Antimicrobial agents and chemotherapy, 2012, Pouillot, Flavie et. al.
A novel and selective monoamine oxidase B substrate
score: 0.95953116, Bioorganic & Medicinal Chemistry, 2005, Rimoldi, John M. et. al.
α-Ketoamides and α-Ketocarbonyls: Conformational analysis and development of all-atom OPLS force field
score: 0.95950061, Bioorganic & Medicinal Chemistry, 2000, Kahn, Kalju; Bruice, Thomas C.
Functionalized analogues of 5,8,10-trideazafolate: Development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase
score: 0.95944176, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L. et. al.
Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate.
score: 0.95933913, Antimicrobial agents and chemotherapy, 2001, Bowman, J C et. al.
Evaluation of a DNA microarray, the check-points ESBL/KPC array, for rapid detection of TEM, SHV, and CTX-M extended-spectrum beta-lactamases and KPC carbapenemases.
score: 0.95899026, Antimicrobial agents and chemotherapy, 2010, Naas, T; Cuzon, G; Truong, H; Bernabeu, S; Nordmann, P
Single strand DNA catenane synthesis using the formation of G-quadruplex structure
score: 0.95895204, Bioorganic & Medicinal Chemistry, 2012, Sannohe, Yuta; Sugiyama, Hiroshi
Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca
score: 0.95864322, Bioorganic & Medicinal Chemistry, 2004, Zhang, Yalin et. al.
A simple method to obtain a covalent immobilized phospholipase A 2
score: 0.95863747, Bioorganic & Medicinal Chemistry Letters, 2001, Madoery, R.R.; Fidelio, G.D.
Risk factors for selection of the L74I reverse transcriptase mutation in human immunodeficiency virus type 1-infected patients.
score: 0.95863491, Antimicrobial agents and chemotherapy, 2006, Wirden, Marc et. al.
Interaction of arylpiperazine ligands with the hydrophobic part of the 5-HT 1A receptor binding site
score: 0.95855465, Bioorganic & Medicinal Chemistry, 2006, Zlatović, Mario V. et. al.
Potential antitumoral properties of a new copper complex with santonic acid
score: 0.95853929, Bioorganic & Medicinal Chemistry, 2008, Williams, Patricia A.M. et. al.
Beta-lactam and fluoroquinolone combination antibiotic therapy for bacteremia caused by gram-negative bacilli.
score: 0.95851347, Antimicrobial agents and chemotherapy, 2009, Al-Hasan, Majdi N et. al.
CmeABC functions as a multidrug efflux system in Campylobacter jejuni.
score: 0.95845741, Antimicrobial agents and chemotherapy, 2002, Lin, Jun; Michel, Linda Overbye; Zhang, Qijing
Cross-linking of proteins by maillard processes—Model reactions of d-glucose or methylglyoxal with butylamine and guanidine derivatives
score: 0.95821257, Bioorganic & Medicinal Chemistry, 1998, Lederer, Markus O; Gerum, Fränzi; Severin, Theodor
A glutamate mutase is involved in the biosynthesis of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis.
score: 0.95818796, Antimicrobial agents and chemotherapy, 2003, Heinzelmann, E et. al.
Proteomic Response of Bacillus subtilis to Lantibiotics Reflects Differences in Interaction with the Cytoplasmic Membrane.
score: 0.95804589, Antimicrobial agents and chemotherapy, 2012, Wenzel, Michaela et. al.
Pharmacokinetics of a fluoronaphthyridone, trovafloxacin (CP 99,219), in infants and children following administration of a single intravenous dose of alatrofloxacin.
score: 0.95802858, Antimicrobial agents and chemotherapy, 2000, Bradley, J S et. al.
Ribosomal protection proteins and their mechanism of tetracycline resistance.
score: 0.95797369, Antimicrobial agents and chemotherapy, 2003, Connell, Sean R et. al.
Fragment-based drug discovery takes a virtual turn.
score: 0.95797077, Nature chemical biology, 2009, Pellecchia, Maurizio
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells
score: 0.95790052, Bioorganic & Medicinal Chemistry, 2006, Doležal, Karel et. al.
Interaction between Artemether-Lumefantrine and Nevirapine-Based Antiretroviral Therapy in HIV-1-Infected Patients.
score: 0.95771395, Antimicrobial agents and chemotherapy, 2011, Kredo, T et. al.
Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis.
score: 0.9577107, Antimicrobial agents and chemotherapy, 2005, Dabur, Rajesh et. al.
The reactivity of phenolic and non-phenolic residual kraft lignin model compounds with Mn(II)-peroxidase from Lentinula edodes
score: 0.95760339, Bioorganic & Medicinal Chemistry, 2000, Crestini, Claudia et. al.
Determination of human serum albumin using an intramolecular charge transfer fluorescence probe: 4′-Dimethylamino-2,5-dihydroxychalcone
score: 0.95755867, Bioorganic & Medicinal Chemistry Letters, 2005, Xu, Zhicheng; Yang, Weibing; Dong, Chuan
Ineffectiveness of echinacea for prevention of experimental rhinovirus colds.
score: 0.95748893, Antimicrobial agents and chemotherapy, 2000, Turner, R B; Riker, D K; Gangemi, J D
The antibiotic monensin causes cell cycle disruption of Toxoplasma gondii mediated through the DNA repair enzyme TgMSH-1.
score: 0.95744539, Antimicrobial agents and chemotherapy, 2011, Lavine, Mark D; Arrizabalaga, Gustavo
The lethal effect of bis-type azridinylnaphthoquinone derivative on oral cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2
score: 0.95736763, Bioorganic & Medicinal Chemistry, 2006, Peng, Yi-Chen et. al.
A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis.
score: 0.95721242, Antimicrobial agents and chemotherapy, 2012, Johnson, Todd J et. al.
D-Ala:D-Ala ligase gene flanking the vanC cluster: evidence for presence of three ligase genes in vancomycin-resistant Enterococcus gallinarum BM4174.
score: 0.95720895, Antimicrobial agents and chemotherapy, 2002, Ambúr, Ole-Herman; Reynolds, Peter E; Arias, Cesar A
Inhibition of herpes simplex virus reactivation by dipyridamole.
score: 0.95707076, Antimicrobial agents and chemotherapy, 2001, Tenser, R B; Gaydos, A; Hay, K A
Synthesis, structural characterization and antitumor activity of novel 2,4-diamino-1,3,5-triazine derivatives
score: 0.95704135, European Journal of Medicinal Chemistry, 2000, Brzozowski, Z.; Sączewski, F.; Gdaniec, M.
Zinc(II) complexes of the second-generation quinolone antibacterial drug enrofloxacin: Structure and DNA or albumin interaction
score: 0.95692922, Bioorganic & Medicinal Chemistry, 2010, Tarushi, Alketa et. al.
Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity
score: 0.95684382, Bioorganic & Medicinal Chemistry, 2013, Ge, Hai-Xia et. al.
Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey.
score: 0.9566853, Antimicrobial agents and chemotherapy, 1999, Fielding, R M; Moon-McDermott, L; Lewis, R O; Horner, M J
New artesunic acid homodimers: Potent reversal agents of multidrug resistance in leukemia cells
score: 0.95667347, Bioorganic & Medicinal Chemistry, 2012, Reiter, Christoph et. al.
DAS181 inhibits H5N1 influenza virus infection of human lung tissues.
score: 0.956666, Antimicrobial agents and chemotherapy, 2009, Chan, Renee W Y et. al.
Synthetic multifunctional pores that open and close in response to chemical stimulation
score: 0.9566567, Bioorganic & Medicinal Chemistry, 2005, Gorteau, Virginie et. al.
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
score: 0.95652086, Antimicrobial agents and chemotherapy, 2003, Komp Lindgren, Patricia; Karlsson, Asa; Hughes, Diarmaid
In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae.
score: 0.95641442, Antimicrobial agents and chemotherapy, 2004, Pereyre, S et. al.
Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation
score: 0.95641141, Bioorganic & Medicinal Chemistry Letters, 1998, Kandimalla, Ekambar R.; Shaw, Denise R.; Agrawal, Sudhir
Neuritogenic cerebrosides from an edible chinese mushroom. Part 2 † † For Part 1, see ref 1. : structures of two additional termitomycesphins and activity enhancement of an inactive cerebroside by hydroxylation
score: 0.95636551, Bioorganic & Medicinal Chemistry, 2001, Qi, Jianhua; Ojika, Makoto; Sakagami, Youji
Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks.
score: 0.95628195, Antimicrobial agents and chemotherapy, 2005, Casey, John et. al.
PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages.
score: 0.95613775, Antimicrobial agents and chemotherapy, 2000, Martin, M et. al.
Six groups of the OXY beta-Lactamase evolved over millions of years in Klebsiella oxytoca.
score: 0.95612379, Antimicrobial agents and chemotherapy, 2005, Fevre, Cindy et. al.
New ether diglycosides from Matayba guianensis with antiplasmodial activity
score: 0.95611152, Bioorganic & Medicinal Chemistry, 2005, de Mesquita, Mariana Laundry et. al.
Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus.
score: 0.95601683, Antimicrobial agents and chemotherapy, 2011, Fan, Zheng et. al.
Ritonavir increases plasma amprenavir (APV) exposure to a similar extent when coadministered with either fosamprenavir or APV.
score: 0.95589181, Antimicrobial agents and chemotherapy, 2006, Wire, Mary B et. al.
Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo
score: 0.95580748, European Journal of Medicinal Chemistry, 2012, Ichihara, Hideaki et. al.
Molecular dynamics simulations on the critical states of the farnesyltransferase enzyme
score: 0.95577518, Bioorganic & Medicinal Chemistry, 2009, Sousa, Sérgio Filipe et. al.
New real-time PCR assay using locked nucleic acid probes to assess prevalence of ParC mutations in fluoroquinolone-susceptible Streptococcus pneumoniae isolates from France.
score: 0.95574031, Antimicrobial agents and chemotherapy, 2006, Decousser, Jean-Winoc et. al.
Nuclear translocation peptides as antibiotics.
score: 0.95572276, Antimicrobial agents and chemotherapy, 2006, Kobayashi, Nahoko; Yamada, Yoshinao; Yoshida, Tetsuhiko
Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)
score: 0.95563665, Bioorganic & Medicinal Chemistry, 2004, Fryatt, Tara et. al.
Increase of β-lactam-resistant invasive Haemophilus influenzae in Sweden, 1997 to 2010.
score: 0.9555863, Antimicrobial agents and chemotherapy, 2012, Resman, Fredrik et. al.
Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials.
score: 0.95548432, Antimicrobial agents and chemotherapy, 2002, Spruance, Spotswood L et. al.
Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents
score: 0.95542822, Bioorganic & Medicinal Chemistry Letters, 2008, Tanaka, Kazuo et. al.
Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum
score: 0.95539516, Bioorganic & Medicinal Chemistry, 2004, Ma, Ji; Jones, Shannon H; Hecht, Sidney M
Synthesis and properties of new substituted 1,2,4-triazoles: potential antitumor agents
score: 0.95514589, Bioorganic & Medicinal Chemistry, 2003, Al-Soud, Yaseen A et. al.
Therapeutic efficacy of human macrophage colony-stimulating factor, used alone and in combination with antifungal agents, in mice with systemic Candida albicans infection.
score: 0.95508997, Antimicrobial agents and chemotherapy, 2000, Kuhara, T; Uchida, K; Yamaguchi, H
MIC-based interspecies prediction of the antimicrobial effects of ciprofloxacin on bacteria of different susceptibilities in an in vitro dynamic model.
score: 0.95506627, Antimicrobial agents and chemotherapy, 1998, Firsov, A A et. al.
Use of pharmacokinetic-pharmacodynamic analyses to optimize therapy with the systemic antifungal micafungin for invasive candidiasis or candidemia.
score: 0.95486419, Antimicrobial agents and chemotherapy, 2011, Andes, David et. al.
Variant Salmonella genomic island 1-L antibiotic resistance gene cluster in Salmonella enterica serovar Newport.
score: 0.95458252, Antimicrobial agents and chemotherapy, 2006, Cloeckaert, Axel et. al.
Pharmacokinetic interaction of abacavir (1592U89) and ethanol in human immunodeficiency virus-infected adults.
score: 0.95450799, Antimicrobial agents and chemotherapy, 2000, McDowell, J A et. al.
Effect of ciprofloxacin-induced prostaglandin E2 on interleukin-18-treated monocytes.
score: 0.9544634, Antimicrobial agents and chemotherapy, 2005, Takahashi, Hideo Kohka et. al.
Perfluorinated markers for hypoxia detection: synthesis of sulfur-containing precursors and [ 18F]-labelling
score: 0.95445316, Bioorganic & Medicinal Chemistry, 2005, Cheguillaume, Arnaud et. al.
Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model.
score: 0.95443399, Antimicrobial agents and chemotherapy, 2005, Faber, Christopher et. al.
Preclinical in vitro and in vivo characterization of the fully human monoclonal IgM antibody KBPA101 specific for Pseudomonas aeruginosa serotype IATS-O11.
score: 0.95430727, Antimicrobial agents and chemotherapy, 2010, Horn, Michael P et. al.
Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma
score: 0.95429208, Bioorganic & Medicinal Chemistry, 1999, Jordan, Allan M. et. al.
Antifungal activities of R-135853, a sordarin derivative, in experimental candidiasis in mice.
score: 0.95428353, Antimicrobial agents and chemotherapy, 2005, Kamai, Yasuki et. al.
Genetic characterization of optochin-susceptible viridans group streptococci.
score: 0.95421382, Antimicrobial agents and chemotherapy, 2003, Martín-Galiano, Antonio J et. al.
Arylisothiocyanate-Containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase
score: 0.95411974, Bioorganic & Medicinal Chemistry, 2001, Zhang, Xuechun et. al.
ISCR2, another vehicle for bla(VEB) gene acquisition.
score: 0.95406733, Antimicrobial agents and chemotherapy, 2009, Poirel, Laurent et. al.
Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.
score: 0.95371362, Antimicrobial agents and chemotherapy, 2008, Jenke, Andreas C W et. al.
Use of terbinafine in mouse and rat models of Pneumocystis carinii pneumonia.
score: 0.95366577, Antimicrobial agents and chemotherapy, 2002, Walzer, Peter D; Ashbaugh, Alan
Syntheses and Kinetic Evaluation of Racemic and Optically Active 2-Benzyl-2-methyl-3,4-epoxybutanoic Acids as Irreversible Inactivators for Carboxypeptidase A
score: 0.95364122, Bioorganic & Medicinal Chemistry, 2002, Lee, Mijoon; Kim, Dong H.
Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo.
score: 0.95359585, Antimicrobial agents and chemotherapy, 2008, Bernstein, David I et. al.
Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine.
score: 0.95346755, Antimicrobial agents and chemotherapy, 2002, Tatsumi, Yoshiyuki et. al.
In vitro system for modeling influenza A virus resistance under drug pressure.
score: 0.95339114, Antimicrobial agents and chemotherapy, 2010, Brown, Ashley N et. al.
Discrepancies between protease inhibitor concentrations and viral load in reservoirs and sanctuary sites in human immunodeficiency virus-infected patients.
score: 0.95332347, Antimicrobial agents and chemotherapy, 2003, Solas, Caroline et. al.
Characterization of a chromosomal gene encoding type B beta-lactamase in phage group II isolates of Staphylococcus aureus.
score: 0.95324225, Antimicrobial agents and chemotherapy, 1998, Voladri, R K; Kernodle, D S
Steroid — DNA conjugates: Improved triplex formation with 5-amido-(7-deoxycholic acid)-dU incorporated oligonucleotides
score: 0.95320836, Bioorganic & Medicinal Chemistry Letters, 1999, Li Yue-Ming, Dimpan Bhatia.; Ganesh, Krishna N
Fluconazole penetration into the pancreas.
score: 0.95319639, Antimicrobial agents and chemotherapy, 2000, Shrikhande, S et. al.
In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketone
score: 0.95311331, Bioorganic & Medicinal Chemistry, 1997, Morris, Tina S et. al.
Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities
score: 0.95309511, Bioorganic & Medicinal Chemistry, 2003, Matsuda, Hisashi et. al.
Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues
score: 0.95308738, European Journal of Medicinal Chemistry, 2003, Budzisz, Elzbieta et. al.
Synthesis and antitumor activity of goniofufurone analogues
score: 0.95296892, Bioorganic & Medicinal Chemistry, 1999, Mereyala, Hari Babu et. al.
Mefloquine versus quinine plus sulphalene-pyrimethamine (metakelfin) for treatment of uncomplicated imported falciparum malaria acquired in Africa.
score: 0.95291476, Antimicrobial agents and chemotherapy, 2005, Matteelli, Alberto et. al.
Photoaffinity labeling of PKC isozymes by phorbol ester derivatives
score: 0.95289287, Bioorganic & Medicinal Chemistry, 1998, Uotsu, Koichiro; Sodeoka, Mikiko; Shibasaki, Masakatsu
Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high-level beta-lactam resistance involves three AmpD homologues.
score: 0.95277811, Antimicrobial agents and chemotherapy, 2006, Juan, Carlos et. al.
In vitro assessment of antifungal therapeutic potential of salivary histatin-5, two variants of histatin-5, and salivary mucin (MUC7) domain 1.
score: 0.95277719, Antimicrobial agents and chemotherapy, 2000, Situ, H; Bobek, L A
Prospective investigation of nasal mupirocin, hexachlorophene body wash, and systemic antibiotics for prevention of recurrent community-associated methicillin-resistant Staphylococcus aureus infections.
score: 0.95275839, Antimicrobial agents and chemotherapy, 2012, Miller, Loren G et. al.
Saquinavir
score: 0.95274432, Bioorganic & Medicinal Chemistry, 1997,
New Cu(II), Co(II), Ni(II) complexes with aroyl-hydrazone based ligand. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation
score: 0.95272923, European Journal of Medicinal Chemistry, 2010, Angelusiu, Madalina Veronica et. al.
Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery.
score: 0.95272206, Antimicrobial agents and chemotherapy, 2011, Douglas, Alexandra et. al.
Association of ITPA gene polymorphisms and the risk of ribavirin-induced anemia in HIV/hepatitis C virus (HCV)-coinfected patients receiving HCV combination therapy.
score: 0.95271393, Antimicrobial agents and chemotherapy, 2012, Domingo, Pere et. al.
Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis.
score: 0.95246853, Antimicrobial agents and chemotherapy, 2005, Ueda, Ohmi et. al.
Active site of an aminoacyl–tRNA synthetase dissected by energy-transfer-dependent fluorescence
score: 0.95242321, Bioorganic & Medicinal Chemistry Letters, 2001, Nomanbhoy, Tyzoon K; Schimmel, Paul
Stochastic-based descriptors studying peptides biological properties: modeling the bitter tasting threshold of dipeptides
score: 0.95242162, Bioorganic & Medicinal Chemistry, 2004, Ramos de Armas, Ronal et. al.
The synthesis of l-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells
score: 0.95232896, Bioorganic & Medicinal Chemistry, 2006, Chen, Jiaojiao; Lu, Min; Jing, Yongkui; Dong, Jinhua
Limited-sampling strategy models for itraconazole and hydroxy-itraconazole based on data from a bioequivalence study.
score: 0.95230185, Antimicrobial agents and chemotherapy, 1999, Suarez-Kurtz, G et. al.
Conformational analysis of the antimalarial agent quinidine
score: 0.95226485, Bioorganic & Medicinal Chemistry, 1997, Silva, Thais H.A. et. al.
Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1.
score: 0.95202488, Antimicrobial agents and chemotherapy, 2000, Uchino, H et. al.
Disposition of posaconazole following single-dose oral administration in healthy subjects.
score: 0.95175262, Antimicrobial agents and chemotherapy, 2004, Krieter, Philip et. al.
α-Peptide/β-sulfonamidopeptide hybrids: Analogs of the chemotactic agent for-Met-Leu-Phe-OMe
score: 0.95171615, Bioorganic & Medicinal Chemistry, 2006, Giordano, Cesare et. al.
Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis.
score: 0.9516402, Antimicrobial agents and chemotherapy, 2007, Shen, Xin et. al.
The ortho hydroxy-amino group: Another choice for synthesizing novel antioxidants
score: 0.95163672, Bioorganic & Medicinal Chemistry Letters, 2006, Chen, Weijun; Guo, Ping; Song, Jirong; Cao, Wei; Bian, Jiang
Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene delivery
score: 0.9516146, Bioorganic & Medicinal Chemistry Letters, 2002, Hasegawa, Seiji; Hirashima, Naohide; Nakanishi, Mamoru
Expanding the 43C9 class of catalytic antibodies using a chain-shuffling approach
score: 0.95161264, Bioorganic & Medicinal Chemistry, 1997, Miller, Grover Paul; Posner, Bruce A.; Benkovic, Stephen J.
Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines
score: 0.95153669, Bioorganic & Medicinal Chemistry, 2006, Cárdenas, Mariano et. al.
Characterization of globally spread Escherichia coli ST131 isolates (1991 to 2010).
score: 0.95152201, Antimicrobial agents and chemotherapy, 2012, Novais, Angela et. al.
Quantitative structure–activity relationship studies on cyclic cyanoguanidines acting as HIV-1 protease inhibitors
score: 0.95146018, Bioorganic & Medicinal Chemistry, 1999, Gupta, S.P.; Suresh Babu, M.
QSAR modeling of acute toxicity by balance of correlations
score: 0.95145043, Bioorganic & Medicinal Chemistry, 2008, Toropov, Andrey A. et. al.
Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa.
score: 0.9514482, Antimicrobial agents and chemotherapy, 1999, Mine, T; Morita, Y; Kataoka, A; Mizushima, T; Tsuchiya, T
Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1 H-benzimidazoles
score: 0.95142268, European Journal of Medicinal Chemistry, 2006, Kumar, Bobba Venkata Siva et. al.
Influence of Vehicles Used for Oral Dosing of Test Molecules on the Progression of Mycobacterium tuberculosis Infection in Mice.
score: 0.95140823, Antimicrobial agents and chemotherapy, 2012, Singh, Shubhra; Dwivedi, Richa; Chaturvedi, Vinita
(3 E,8 Z,11 Z)-3,8,11-Tetradecatrienyl acetate, major sex pheromone component of the tomato pest Scrobipalpuloides absoluta (Lepidoptera: Gelechiidae)
score: 0.95135349, Bioorganic & Medicinal Chemistry, 1996, Attygalle, Athula B. et. al.
Streptococcus gordonii strains resistant to fluorodeoxyuridine contain mutations in the thymidine kinase gene and are deficient in thymidine kinase activity.
score: 0.95130385, Antimicrobial agents and chemotherapy, 2000, Franke, C A; Bolman, T M; Ottum, S A; Jones, K F; Hruby, D E
The macrolide roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane in vitro.
score: 0.9512823, Antimicrobial agents and chemotherapy, 2005, Abdelghaffar, Houria et. al.
Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes.
score: 0.9512788, Nature chemical biology, 2008, Kaplun, Alexander et. al.
Rapid isolation of novel FK506 binding proteins from multiple organisms using gDNA and cDNA T7 phage display
score: 0.95127183, Bioorganic & Medicinal Chemistry, 2009, Piggott, Andrew M. et. al.
Selective cleavages of tRNA Phe with secondary and tertiary structures by enediyne antitumor antibiotics
score: 0.95125878, Bioorganic & Medicinal Chemistry, 1997, Sugiura, Yukio et. al.
Detection of florfenicol resistance genes in Escherichia coli isolated from sick chickens.
score: 0.95108331, Antimicrobial agents and chemotherapy, 2000, Keyes, K et. al.
Interspecies comparison of pharmacokinetics of the novel triazole antifungal agent SYN-2869 and its derivatives.
score: 0.95104637, Antimicrobial agents and chemotherapy, 2000, Khan, J K et. al.
Use of real-time PCR and fluorimetry to detect lamivudine resistance-associated mutations in hepatitis B virus.
score: 0.9510342, Antimicrobial agents and chemotherapy, 1999, Cane, P A; Cook, P; Ratcliffe, D; Mutimer, D; Pillay, D
Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis.
score: 0.95102989, Antimicrobial agents and chemotherapy, 2004, Alberola, J et. al.
Modes of antifungal action of alkanols against Saccharomyces cerevisiae
score: 0.95100393, Bioorganic & Medicinal Chemistry, 2003, Kubo, Isao; Fujita, Tomoko; Kubo, Aya; Fujita, Ken-ichi
Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing.
score: 0.9509995, Antimicrobial agents and chemotherapy, 2012, Davis, David A et. al.
Pharmacokinetics of dapsone administered daily and weekly in human immunodeficiency virus-infected children.
score: 0.95098615, Antimicrobial agents and chemotherapy, 1999, Mirochnick, M et. al.
Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis.
score: 0.950806, Antimicrobial agents and chemotherapy, 2002, Rogers, P David; Barker, Katherine S
Immunity to the bacteriocin sublancin 168 Is determined by the SunI (YolF) protein of Bacillus subtilis.
score: 0.95076197, Antimicrobial agents and chemotherapy, 2009, Dubois, Jean-Yves F et. al.
Interaction between fosamprenavir, with and without ritonavir, and nevirapine in human immunodeficiency virus-infected subjects.
score: 0.95070879, Antimicrobial agents and chemotherapy, 2006, DeJesus, Edwin et. al.
Combining NMR and molecular modelling in a drug delivery context: investigation of the multi-mode inclusion of a new NPY-5 antagonist bromobenzenesulfonamide into β-cyclodextrin
score: 0.95056279, Bioorganic & Medicinal Chemistry, 2004, Uccello-Barretta, Gloria et. al.
Selenotyrosine and related phenylalanine derivatives
score: 0.95053907, Bioorganic & Medicinal Chemistry, 2001, Ganther, Howard E
Solution-phase synthesis of combinatorial libraries designed to modulate protein–protein or protein–DNA interactions
score: 0.95049417, Bioorganic & Medicinal Chemistry, 2003, Boger, Dale L
Inhibitory activities of colicins against Escherichia coli strains responsible for postweaning diarrhea and edema disease in swine.
score: 0.95046979, Antimicrobial agents and chemotherapy, 2004, Stahl, Chad H et. al.
Broad-spectrum antimicrobial activity of hemoglobin
score: 0.95043974, Bioorganic & Medicinal Chemistry, 2001, A. Parish, Craig et. al.
Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)
score: 0.95042091, Bioorganic & Medicinal Chemistry Letters, 2012, Qian, Wen-Jian et. al.
Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)
score: 0.95042091, Bioorganic & Medicinal Chemistry Letters, 2012, Qian, Wen-Jian et. al.
Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)
score: 0.95042091, Bioorganic & Medicinal Chemistry Letters, 2012, Qian, Wen-Jian et. al.
Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice.
score: 0.95037633, Antimicrobial agents and chemotherapy, 2005, Erkkilä, Leena et. al.
Additive SMILES-based optimal descriptors in QSAR modelling bee toxicity: Using rare SMILES attributes to define the applicability domain
score: 0.95037266, Bioorganic & Medicinal Chemistry, 2008, Toropov, A.A.; Benfenati, E.
Complete Sequence of p07-406, a 24,179-base-pair plasmid harboring the blaVIM-7 metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.
score: 0.95022064, Antimicrobial agents and chemotherapy, 2008, Li, Hongyang et. al.
MDR1-mediated drug resistance in Candida dubliniensis.
score: 0.95015386, Antimicrobial agents and chemotherapy, 2001, Wirsching, S et. al.
Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formation.
score: 0.95009409, Antimicrobial agents and chemotherapy, 2006, Vaillant, Andrew et. al.
New sesquiterpenic phytotoxins establish unprecedented relationship between different groups of blackleg fungal isolates
score: 0.95005477, Bioorganic & Medicinal Chemistry, 2005, Pedras, M. Soledade C. et. al.
Functionalized oligoanthranilamides: modular and conformationally controlled scaffolds
score: 0.95004514, Bioorganic & Medicinal Chemistry, 2001, Hamuro, Yoshitomo; Hamilton, Andrew D
Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocyte proliferation
score: 0.95002769, Bioorganic & Medicinal Chemistry, 2004, Cerqueira, F et. al.
Stability of colistimethate sodium in aqueous solution.
score: 0.95001386, Antimicrobial agents and chemotherapy, 2012, Healan, A M et. al.
Efficient solid-phase synthesis of oligodeoxynucleotides having a 5′-terminal 2,2,7-trimethylguanosine pyrophosphate linkage
score: 0.94989729, Bioorganic & Medicinal Chemistry, 2009, Ohkubo, Akihiro et. al.
Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol
score: 0.94988246, Bioorganic & Medicinal Chemistry, 2001, Huang, Qiulong et. al.
Fluorescent monitoring of kinase activity in real time: development of a robust fluorescence-based assay for Abl tyrosine kinase activity
score: 0.94976387, Bioorganic & Medicinal Chemistry Letters, 2001, Hofmann, Roseanne M. et. al.
Intravesical nitric oxide delivery for prevention of catheter-associated urinary tract infections.
score: 0.94963048, Antimicrobial agents and chemotherapy, 2005, Carlsson, Stefan et. al.
Activities of a nitrofurazone-containing urinary catheter and a silver hydrogel catheter against multidrug-resistant bacteria characteristic of catheter-associated urinary tract infection.
score: 0.94950097, Antimicrobial agents and chemotherapy, 1999, Johnson, J R; Delavari, P; Azar, M
Insight into the reactive form of the anticancer agent iproplatin
score: 0.94943061, European Journal of Medicinal Chemistry, 2008, Volckova, Erika; Weaver, Evelyne; Bose, Rathindra N.
Direct assay for α-amylase using fluorophore-modified cyclodextrins
score: 0.94939485, Bioorganic & Medicinal Chemistry, 2006, Murayama, Takuya et. al.
DNA Triple Helix Stabilization by Aminoglycoside Antibiotics
score: 0.94936259, Bioorganic & Medicinal Chemistry Letters, 2000, Arya, Dev P; Coffee, R.Lane
Alendronate
score: 0.94934055, Bioorganic & Medicinal Chemistry, 1996, Shinkai, Ichiro; Ohta, Yukari
2,3-Dimethoxybenzo[ i]phenanthridines: topoisomerase I-targeting anticancer agents
score: 0.94928865, Bioorganic & Medicinal Chemistry, 2003, Li, Dajie et. al.
Opposite vascular activity of (R)-apomorphine and its oxidised derivatives. Endothelium-dependent vasoconstriction induced by the auto-oxidation metabolite
score: 0.94919745, European Journal of Medicinal Chemistry, 2003, Abarca, Belén et. al.
Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: Relevance of DNA and protein interactions for their mechanism of action
score: 0.94913712, European Journal of Medicinal Chemistry, 2012, Gouvea, Ligiane R. et. al.
Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.
score: 0.9491144, Antimicrobial agents and chemotherapy, 2002, Rawat, Mamta et. al.
The effect of individual N-glycans on enzyme activity
score: 0.94894186, Bioorganic & Medicinal Chemistry, 2009, Skropeta, Danielle
An aspartic protease analogue: intermolecular catalysis of peptide hydrolysis by carboxyl groups
score: 0.94891871, Bioorganic & Medicinal Chemistry Letters, 2001, Oh, Sezu; Chang, Wonsuk; Suh, Junghun
In vitro activities of terbinafine against Aspergillus species in comparison with those of itraconazole and amphotericin B.
score: 0.94875309, Antimicrobial agents and chemotherapy, 2001, Moore, C B; Walls, C M; Denning, D W
Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor.
score: 0.94872615, Antimicrobial agents and chemotherapy, 2003, Phan, Dana D et. al.
Lipase-catalyzed acetylation of N-acetylneuraminic acid deiivative
score: 0.94864628, Bioorganic & Medicinal Chemistry Letters, 1999, Lo, Lee-Chiang et. al.
Potent inhibition of protein-tyrosine phosphatase by phosphotyrosine-mimic containing cyclic peptides
score: 0.94863951, Bioorganic & Medicinal Chemistry, 1997, Akamatsu, Miki et. al.
Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing.
score: 0.94855604, Antimicrobial agents and chemotherapy, 2007, Hope, William W et. al.
The synthesis and biological evaluation of 4- p-nitrobenzylthio- v-triazolo [4,5- d]pyridazine and imidazo[4,5- d]pyridazine ribosides as potential nucleoside transport inhibitors
score: 0.94833999, Bioorganic & Medicinal Chemistry, 1996, Bussolari, Jacqueline C. et. al.
Characterization of fertilinβ-disintegrin binding specificity in sperm–egg adhesion
score: 0.94829939, Bioorganic & Medicinal Chemistry, 2000, Gupta, Suparna; Li, Haishan; Sampson, Nicole S
P glycoprotein in human immunodeficiency virus type 1 infection and therapy.
score: 0.94817929, Antimicrobial agents and chemotherapy, 2004, Sankatsing, Sanjay U C et. al.
Amide and α-keto carbonyl inhibitors of thrombin based on arginine and lysine: Synthesis, stability and biological characterization
score: 0.94811082, Bioorganic & Medicinal Chemistry, 1995, Brady, Stephen F. et. al.
Biomimetic synthesis of acid-sensitive (−)- and (+)-caparrapi oxides, (−)- and (+)-8-epicaparrapi oxides, and (+)-dysifragin induced by artificial cyclases
score: 0.94808666, Bioorganic & Medicinal Chemistry, 2005, Uyanik, Muhammet; Ishihara, Kazuaki; Yamamoto, Hisashi
Synthetic analogues of beta-1,2 oligomannosides prevent intestinal colonization by the pathogenic yeast Candida albicans.
score: 0.94807715, Antimicrobial agents and chemotherapy, 2002, Dromer, Françoise et. al.
Electrolytic generation of oxygen partially explains electrical enhancement of tobramycin efficacy against Pseudomonas aeruginosa biofilm.
score: 0.94807002, Antimicrobial agents and chemotherapy, 1999, Stewart, P S et. al.
Evaluations of shorter exposures of contact lens cleaning solutions against Fusarium oxysporum species complex and Fusarium solani species complex to simulate inappropriate usage.
score: 0.94806788, Antimicrobial agents and chemotherapy, 2011, Ramani, Rama; Chaturvedi, Vishnu
De novo design, synthesis and evaluation of a non-steroidal diphenylnaphthyl propylene ligand for the estrogen receptor
score: 0.94798116, Bioorganic & Medicinal Chemistry, 2003, Schmidt, Jonathan M et. al.
Antibacterial properties of an oligo-acyl-lysyl hexamer targeting Gram-negative species.
score: 0.94793677, Antimicrobial agents and chemotherapy, 2012, Zaknoon, Fadia et. al.
Importance of collection tube during clinical studies of oseltamivir.
score: 0.94790923, Antimicrobial agents and chemotherapy, 2007, Lindegardh, Niklas et. al.
Antioxidant activity of N-carboxymethyl chitosan oligosaccharides
score: 0.94790053, Bioorganic & Medicinal Chemistry Letters, 2008, Sun, Tao; Yao, Qian; Zhou, Dongxiang; Mao, Fang
Therapeutic potential of human neutrophil peptide 1 against experimental tuberculosis.
score: 0.94772131, Antimicrobial agents and chemotherapy, 2001, Sharma, S; Verma, I; Khuller, G K
Diversity-Oriented Synthesis Approach to Macrocycles via Oxidative Ring Expansion
score: 0.94768829, Nature Chemical Biology, 2012, Kopp, Felix et. al.
Mechanism of toxicity of esters of Caffeic and dihydrocaffeic acids
score: 0.9476289, Bioorganic & Medicinal Chemistry, 2001, Etzenhouser, Beth et. al.
Discovery of 1-(β-amino substituted-β-alanyl)-N,N-dimethylindoline-2-carboxamides as novel nonpeptide antagonists of nociceptin/orphanin FQ receptor: Efficient design, synthesis, and structure–activity relationship studies
score: 0.94748343, European Journal of Medicinal Chemistry, 2012, Hayashi, Shigeo; Ohashi, Katsuyo; Nakata, Eriko; Emoto, Chie
Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)–malonato–Pt–DACH conjugates
score: 0.94744827, European Journal of Medicinal Chemistry, 2003, Furin, Alessia et. al.
Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury.
score: 0.94744625, Antimicrobial agents and chemotherapy, 2008, Mohr, John F et. al.
Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis.
score: 0.94735842, Antimicrobial agents and chemotherapy, 2007, Scorpio, Angelo et. al.
Intrinsic macrolide resistance in rapidly growing mycobacteria.
score: 0.94735239, Antimicrobial agents and chemotherapy, 2006, Nash, Kevin A et. al.
4-Substituted anilino imidazo[1,2-a] and triazolo[4,3-a]quinoxalines. Synthesis and evaluation of in vitro biological activity
score: 0.94734039, European Journal of Medicinal Chemistry, 2006, Corona, Paola et. al.
The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.
score: 0.94733581, Antimicrobial agents and chemotherapy, 2004, Song, Jia L et. al.
Are SHV beta-lactamases universal in Klebsiella pneumoniae?
score: 0.94732421, Antimicrobial agents and chemotherapy, 2000, Babini, G S; Livermore, D M
Anion recognition by Thiostrepton
score: 0.9472851, Bioorganic & Medicinal Chemistry Letters, 2001, Godoy-Alcántar, Carolina et. al.
Getting pharmaceutical R&D back on target.
score: 0.94716844, Nature chemical biology, 2011, Bunnage, Mark E
In vitro activities of ABT-773, a new ketolide, against aerobic and anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis.
score: 0.94713498, Antimicrobial agents and chemotherapy, 2001, Goldstein, E J et. al.
Sequencing of the rpoB gene in Legionella pneumophila and characterization of mutations associated with rifampin resistance in the Legionellaceae.
score: 0.94711184, Antimicrobial agents and chemotherapy, 2000, Nielsen, K; Hindersson, P; Hoiby, N; Bangsborg, J M
c-nucleoside analogues of furanfurin as ligands to a 1 adenosine receptors
score: 0.94707823, Bioorganic & Medicinal Chemistry, 2000, Franchetti, Palmarisa et. al.
Posaconazole in human serum: a greater pharmacodynamic effect than predicted by the non-protein-bound serum concentration.
score: 0.9470529, Antimicrobial agents and chemotherapy, 2011, Lignell, Anders et. al.
Macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes in the pediatric population in Germany during 2000-2001.
score: 0.94689292, Antimicrobial agents and chemotherapy, 2003, Reinert, Ralf René et. al.
Rational design of dynorphin A analogues with δ-receptor selectivity and antagonism for δ- and κ-receptors
score: 0.94682837, Bioorganic & Medicinal Chemistry, 1998, Guerrini, Remo et. al.
Effect of zinc salts on respiratory syncytial virus replication.
score: 0.94673498, Antimicrobial agents and chemotherapy, 2004, Suara, Rahaman O; Crowe, James E
Antibacterial and DNA interaction studies of zinc(II) complexes with quinolone family member, ciprofloxacin
score: 0.94668657, European Journal of Medicinal Chemistry, 2010, Patel, Mohan; Chhasatia, Mehul; Parmar, Pradhuman
In vitro anti-Trypanosoma cruzi activity of dronedarone, a novel amiodarone derivative with an improved safety profile.
score: 0.94653649, Antimicrobial agents and chemotherapy, 2012, Benaim, Gustavo et. al.
Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315.
score: 0.94647683, Antimicrobial agents and chemotherapy, 1999, Ito, T; Katayama, Y; Hiramatsu, K
Monoclonal antibody mediated intracellular targeting of tallysomycin S 10b
score: 0.94642618, Bioorganic & Medicinal Chemistry Letters, 2004, Walker, Michael A et. al.
Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan.
score: 0.94630605, Antimicrobial agents and chemotherapy, 2004, Sanbongi, Yumiko et. al.
Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of Clostridium difficile-associated diarrhea in hospitalized patients.
score: 0.94613721, Antimicrobial agents and chemotherapy, 2009, Aldeyab, Mamoon A et. al.
A quantum chemical and statistical study of flavonoid compounds (flavones) with anti-HIV activity
score: 0.9460828, European Journal of Medicinal Chemistry, 2003, Souza, Jaime et. al.
Efficacy of LY303366 against amphotericin B-susceptible and -resistant Aspergillus fumigatus in a murine model of invasive aspergillosis.
score: 0.94603148, Antimicrobial agents and chemotherapy, 1998, Verweij, P E et. al.
Fluconazole versus Candida albicans: a complex relationship.
score: 0.94591846, Antimicrobial agents and chemotherapy, 1998, Graybill, J R et. al.
Initial concentration-time profile of gentamicin determines efficacy against Enterobacter cloacae ATCC 13047.
score: 0.94587003, Antimicrobial agents and chemotherapy, 1998, Rayner, C R et. al.
Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1.
score: 0.94585442, Antimicrobial agents and chemotherapy, 1999, Billman-Jacobe, H; Haites, R E; Coppel, R L
Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challenge.
score: 0.94582524, Antimicrobial agents and chemotherapy, 2005, Ulrich, Martina et. al.
Clinical efficacy of intravenous followed by oral azithromycin monotherapy in hospitalized patients with community-acquired pneumonia. The Azithromycin Intravenous Clinical Trials Group.
score: 0.94574842, Antimicrobial agents and chemotherapy, 2000, Plouffe, J et. al.
Detection of DNA hybridization on a liposome surface using ultrasound velocimetry and turbidimetry methods
score: 0.94558829, Bioorganic & Medicinal Chemistry Letters, 2004, Hianik, Tibor et. al.
Synthesis and activity of pyrrolidinyl- and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi
score: 0.94557328, European Journal of Medicinal Chemistry, 2000, Joyeau, Roger et. al.
Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl- l-cysteine—Preparation of S-substituted thiosuccinic acid esters
score: 0.94556318, Bioorganic & Medicinal Chemistry, 2007, Schmidt, Thomas J.; Ak, Muharrem; Mrowietz, Ulrich
Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis.
score: 0.9455133, Antimicrobial agents and chemotherapy, 2005, Larsen, Robert A et. al.
Bacteriophage therapy.
score: 0.9453334, Antimicrobial agents and chemotherapy, 2001, Sulakvelidze, A; Alavidze, Z; Morris, J G
Effect of metronidazole resistance on bacterial eradication of Helicobacter pylori in infected children.
score: 0.94529411, Antimicrobial agents and chemotherapy, 1998, Raymond, J et. al.
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action
score: 0.94520326, Bioorganic & Medicinal Chemistry, 2012, Fioravanti, Rossella et. al.
Association of a thr-371 substitution in a conserved amino acid motif of penicillin-binding protein 1A with penicillin resistance of Streptococcus pneumoniae.
score: 0.94514697, Antimicrobial agents and chemotherapy, 1998, Asahi, Y; Ubukata, K
N,N-Disubstituted Aminomethyl Benzofuran Derivatives: Synthesis and Preliminary Binding Evaluation
score: 0.94514118, Bioorganic & Medicinal Chemistry, 1999, Boyé, Sophie et. al.
The influence of hydroquinone on tyrosinase kinetics
score: 0.94511419, Bioorganic & Medicinal Chemistry, 2012, Stratford, Michael R.L. et. al.
The influence of hydroquinone on tyrosinase kinetics
score: 0.94511419, Bioorganic & Medicinal Chemistry, 2012, Stratford, Michael R.L. et. al.
The influence of hydroquinone on tyrosinase kinetics
score: 0.94511419, Bioorganic & Medicinal Chemistry, 2012, Stratford, Michael R.L. et. al.
Interaction of antimycobacterial drugs with the anti-Mycobacterium avium complex effects of antimicrobial effectors, reactive oxygen intermediates, reactive nitrogen intermediates, and free fatty acids produced by macrophages.
score: 0.94508817, Antimicrobial agents and chemotherapy, 2004, Sano, Keisuke et. al.
Original preparation of conjugates for antibody production against Amicoumacin-related anti-microbial agents
score: 0.94507829, Bioorganic & Medicinal Chemistry, 2008, Shinkaruk, Svitlana et. al.
Distribution of Spontaneous gyrA Mutations in 97 Fluoroquinolone-Resistant Helicobacter pylori Isolates Collected in France.
score: 0.94502146, Antimicrobial agents and chemotherapy, 2012, Garcia, Magali et. al.
The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core
score: 0.94493909, Bioorganic & Medicinal Chemistry, 2000, Zhou, Genfa et. al.
Glycopolydiacetylene nanoparticles as a chromatic biosensor to detect Shiga-like toxin producing Escherichia coli O157:H7
score: 0.94491584, Bioorganic & Medicinal Chemistry Letters, 2008, Nagy, Jon O. et. al.
Changes in the antigenicity of a hepatitis B virus mutant stemming from lamivudine therapy.
score: 0.94488419, Antimicrobial agents and chemotherapy, 2000, Chen, W N; Oon, C J
Aromatic–aromatic and proline–aromatic interactions in endomorphin-1 and endomorphin-2
score: 0.94481176, European Journal of Medicinal Chemistry, 2005, Leitgeb, Balázs; Tóth, Géza
Single-dose pharmacokinetics of amprenavir, a human immunodeficiency virus type 1 protease inhibitor, in subjects with normal or impaired hepatic function.
score: 0.94479367, Antimicrobial agents and chemotherapy, 2000, Veronese, L et. al.
Self-Assembly of synthetic zinc chlorins in a silicate micelle prepared by sol-gel process
score: 0.94474971, Bioorganic & Medicinal Chemistry Letters, 2002, Saga, Yoshitaka; Miyatake, Tomohiro; Tamiaki, Hitoshi
Strategy for RNA recognition by yeast histidyl-tRNA synthetase
score: 0.94464566, Bioorganic & Medicinal Chemistry, 1997, Rudinger, Joëlle et. al.
Molecular characterization of the plasma membrane H(+)-ATPase, an antifungal target in Cryptococcus neoformans.
score: 0.94447743, Antimicrobial agents and chemotherapy, 2000, Soteropoulos, P et. al.
Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A.
score: 0.94433926, Antimicrobial agents and chemotherapy, 2001, Desta, Z; Soukhova, N V; Flockhart, D A
Synthesis, antibacterial and antifungal activity of some new pyridazinone metal complexes
score: 0.94430203, European Journal of Medicinal Chemistry, 2006, Sönmez, Mehmet; Berber, İsmet; Akbaş, Esvet
UV–visible spectral identification of the solution-phase and solid-phase permanganate oxidation reactions of thymine acetic acid
score: 0.94423023, Bioorganic & Medicinal Chemistry Letters, 2004, Bui, Chinh T.; Sam, Lien A.; Cotton, Richard G.H.
Distribution of subclasses mefA and mefE of the mefA gene among clinical isolates of macrolide-resistant (M-phenotype) Streptococcus pneumoniae, viridans group streptococci, and Streptococcus pyogenes.
score: 0.94422775, Antimicrobial agents and chemotherapy, 2005, Ardanuy, Carmen et. al.
Effect of protonation of the N-acetyl neuraminic acid residue of sialyl lewis X
score: 0.94412174, Bioorganic & Medicinal Chemistry, 2002, Pichierri, Fabio; Matsuo, Yo
Molecular characterization of multidrug resistance in Streptococcus mitis.
score: 0.94401433, Antimicrobial agents and chemotherapy, 1999, Poutanen, S M et. al.
Organoiodine (III) mediated synthesis of 3-aryl/hetryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines as antibacterial agents
score: 0.94384839, European Journal of Medicinal Chemistry, 2004, Prakash, Om et. al.
Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermedia.
score: 0.94377211, Antimicrobial agents and chemotherapy, 2009, Wakabayashi, Hiroyuki et. al.
Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport.
score: 0.94376114, Antimicrobial agents and chemotherapy, 2006, Yamaguchi, Shoji et. al.
Structure–activity relationships of novel P2-receptor antagonists structurally related to Reactive Blue 2
score: 0.94375551, European Journal of Medicinal Chemistry, 2005, Glänzel, Markus et. al.
[18F]Ciprofloxacin, a new positron emission tomography tracer for noninvasive assessment of the tissue distribution and pharmacokinetics of ciprofloxacin in humans.
score: 0.94373567, Antimicrobial agents and chemotherapy, 2004, Brunner, Martin et. al.
Development of a fluorescent intercalator displacement assay (G4-FID) for establishing quadruplex-DNA affinity and selectivity of putative ligands
score: 0.94369911, Bioorganic & Medicinal Chemistry Letters, 2006, Monchaud, David et. al.
Structure–affinity relationships of halogenated predicentrine and glaucine derivatives at D 1 and D 2 dopaminergic receptors: halogenation and D 1 receptor selectivity
score: 0.94369562, Bioorganic & Medicinal Chemistry, 2005, Asencio, Marcelo et. al.
Posttreatment changes in Escherichia coli antimicrobial susceptibility rates among diarrheic patients treated with ciprofloxacin.
score: 0.94369335, Antimicrobial agents and chemotherapy, 2005, Putnam, Shannon D et. al.
New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity
score: 0.9436612, European Journal of Medicinal Chemistry, 2010, Krstić, Milena et. al.
Lack of ritonavir antifungal effect in vitro.
score: 0.94356287, Antimicrobial agents and chemotherapy, 1999, Diz, P; Ocampo, A; Iglesias, I; Otero, I
Identification of tripeptides recognized by the PDZ domain of Dishevelled
score: 0.94355774, Bioorganic & Medicinal Chemistry, 2009, Lee, Ho-Jin; Wang, Nick X.; Shao, Youming; Zheng, Jie J.
Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes.
score: 0.94351944, Antimicrobial agents and chemotherapy, 2003, Li, Xian-Zhi; Poole, Keith; Nikaido, Hiroshi
Sculpted immunogens; B-cell epitope optimization using constrained secondary structure libraries
score: 0.94349492, Bioorganic & Medicinal Chemistry, 1996, Urban, Jan et. al.
Immunochromatographic strip test for rapid detection of nevirapine in plasma samples from human immunodeficiency virus-infected patients.
score: 0.94347203, Antimicrobial agents and chemotherapy, 2007, Cressey, Tim R et. al.
Rapid biochemical synthesis of 11C-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis
score: 0.94342176, Bioorganic & Medicinal Chemistry, 2012, Matsuda, Takayoshi et. al.
Rapid biochemical synthesis of 11C-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis
score: 0.94342176, Bioorganic & Medicinal Chemistry, 2012, Matsuda, Takayoshi et. al.
Rapid biochemical synthesis of 11C-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis
score: 0.94342176, Bioorganic & Medicinal Chemistry, 2012, Matsuda, Takayoshi et. al.
Linckosides C–E, three new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
score: 0.9433426, Bioorganic & Medicinal Chemistry, 2004, Qi, Jianhua; Ojika, Makoto; Sakagami, Youji
Identification of putative steroid-binding sites in human ABCB1 and ABCG2
score: 0.9432755, European Journal of Medicinal Chemistry, 2009, Mares-Sámano, Sergio; Badhan, Raj; Penny, Jeffrey
Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis.
score: 0.9431101, Antimicrobial agents and chemotherapy, 2000, Aviles, P; Falcoz, C; San Roman, R; Gargallo-Viola, D
Antileishmanial activity of the antiulcer agent omeprazole.
score: 0.94300614, Antimicrobial agents and chemotherapy, 2002, Jiang, Suping et. al.
Chemoenzymatic synthesis of ( E)-3,7-dimethyl-2-octene-1,8-diol isolated from the hairpencils of male danaus chrysippus (African monarch)
score: 0.94288523, Bioorganic & Medicinal Chemistry Letters, 2003, Takabe, Kunihiko et. al.
Erythromycin biosynthesis. The 4- pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase
score: 0.94287743, Bioorganic & Medicinal Chemistry Letters, 2001, Yin, Yifeng et. al.
chemistry of opium alkaloids. part 44: Synthesis and opioid receptor binding profile of substituted ethenoisomorphinans and ethenomorphinans 1 Part XLIII. Baas, J. M. A.; Woudenberg, R. H.; Maat, L. Liebigs Ann./Recueil 1997, 13. 1
score: 0.94284357, Bioorganic & Medicinal Chemistry, 1999, Maat, Leendert et. al.
Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes.
score: 0.94281464, Antimicrobial agents and chemotherapy, 2011, Brenciani, Andrea et. al.
Copper-Promoted overall transformation of 4- tert-butylphenol to its para-hydroxyquinonic derivative, 2-hydroxy-5- tert-butyl-1,4-benzoquinone. Biomimetic studies on the generation of topaquinone in copper amine oxidases
score: 0.94279945, Bioorganic & Medicinal Chemistry Letters, 2000, Rinaldi, Andrea C et. al.
Pharmacokinetics of indinavir combined with low-dose ritonavir in human immunodeficiency virus type 1-infected children.
score: 0.94274481, Antimicrobial agents and chemotherapy, 2004, Bergshoeff, A S et. al.
Hybrid peptides constructed from RES-701-1, an endothelin B receptor antagonist, and endothelin; binding selectivity for endothelin receptors and their pharmacological activity
score: 0.9426737, Bioorganic & Medicinal Chemistry, 1998, Shibata, Kenji et. al.
Synthesis, immunological activities, and scavenging ability toward superoxide anion of (1→3)-β- d-pentaglucoside and its epoxyalkyl derivatives
score: 0.94261415, Bioorganic & Medicinal Chemistry, 2005, Huang, Gang-Liang; Liu, Man-Xi; Mei, Xin-Ya; Wang, Ying
Bifunctional CD4-DC-SIGN fusion proteins demonstrate enhanced avidity to gp120 and inhibit HIV-1 infection and dissemination.
score: 0.94251674, Antimicrobial agents and chemotherapy, 2012, Du, Tao et. al.
Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice.
score: 0.9423654, Antimicrobial agents and chemotherapy, 2000, Consigny, S; Bentoucha, A; Bonnafous, P; Grosset, J; Ji, B
Cancer chemopreventive activity of sulforamate derivatives
score: 0.94232553, European Journal of Medicinal Chemistry, 2006, Moriarty, Robert M. et. al.
Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-Acetylglucosamine sugar with simple C 2-symmetric 1,2-diols
score: 0.94220547, Bioorganic & Medicinal Chemistry, 1996, Prodger, Jeremy C. et. al.
Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats.
score: 0.94214789, Antimicrobial agents and chemotherapy, 2002, Smolders, I et. al.
Modulating pyridoxamine-mediated transamination through a ββα motif peptide scaffold
score: 0.94209031, Bioorganic & Medicinal Chemistry, 1999, Shogren-Knaak, Michael A; Imperiali, Barbara
New screening tools for lead compound identification.
score: 0.94201279, Nature chemical biology, 2005, Sawyer, Tomi K
The synthesis and immunosuppressive activities of steroid–urotoxin linkers
score: 0.94194992, Bioorganic & Medicinal Chemistry, 2004, Wang, Chao; Zhao, Ming; Qiu, Xuecai; Peng, Shiqi
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein
score: 0.94183702, Bioorganic & Medicinal Chemistry, 2012, Miyamae, Yusaku et. al.
Production of enterocin P, an antilisterial pediocin-like bacteriocin from Enterococcus faecium P13, in Pichia pastoris.
score: 0.94181914, Antimicrobial agents and chemotherapy, 2005, Gutiérrez, Jorge et. al.
Synthesis, structural investigations and biological evaluation of novel hexahydropyridazine-1-carboximidamides, -carbothioamides and -carbothioimidic acid esters as inducible nitric oxide synthase inhibitors
score: 0.94173994, Bioorganic & Medicinal Chemistry, 2004, Morgenstern, Olaf et. al.
Comparative drug disposition, urinary pharmacokinetics, and renal effects of multilamellar liposomal nystatin and amphotericin B deoxycholate in rabbits.
score: 0.94151032, Antimicrobial agents and chemotherapy, 2003, Groll, Andreas H et. al.
On how the conformation of biliverdins influences their reduction to bilirubins: A biological and molecular modeling study
score: 0.94146087, Bioorganic & Medicinal Chemistry, 2003, Mora, Marı́a E et. al.
Characterization of multivalent lactose quantum dots and its application in carbohydrate–protein interactions study and cell imaging
score: 0.9414277, Bioorganic & Medicinal Chemistry, 2010, Yang, Yang et. al.
Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE 2 derivatives
score: 0.94138394, Bioorganic & Medicinal Chemistry, 2002, Tani, Kousuke et. al.
Hepatoprotective principles from the flowers of Tilia argentea (Linden): structure requirements of tiliroside and mechanisms of action
score: 0.94128918, Bioorganic & Medicinal Chemistry, 2002, Matsuda, Hisashi et. al.
Piperazine N-substituted naphthyridines, pyridothienopyrimidines and pyridothienotriazines: new antiprotozoals active against Philasterides dicentrarchi
score: 0.94126726, European Journal of Medicinal Chemistry, 2003, Quintela, José M et. al.
In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.
score: 0.94119054, Antimicrobial agents and chemotherapy, 2003, Williams, Stephanie L et. al.
Molecular Modeling on Structure-Function Analysis of Human Progesterone Receptor Modulators
score: 0.94113626, Scientia Pharmaceutica, 2011, Pal, Ria; Islam, Md Ataul; Hossain, Tabassum; Saha, Achintya
Synthesis of fluorescent microgonotropens (FMGTs) and their interactions with dsDNA
score: 0.94109995, Bioorganic & Medicinal Chemistry, 2000, Satz, Alexander L; Bruice, Thomas C
Synthesis and Cytotoxicity of 2-Methyl-1-substituted-imidazo[4,5- g]quinoline-4,9-dione and 7,8-dihydro-10 H-[1,4]oxazino[3′,4′:2,3]imidazo[4,5- g]quinoline-5,12-dione Derivatives
score: 0.94103494, Bioorganic & Medicinal Chemistry, 2000, Suh, Myung-Eun et. al.
Modular structure of microcin H47 and colicin V.
score: 0.94102589, Antimicrobial agents and chemotherapy, 2007, Azpiroz, María F; Laviña, Magela
Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?
score: 0.94095915, Bioorganic & Medicinal Chemistry, 2006, Václavíková, Radka et. al.
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design
score: 0.94092362, Bioorganic & Medicinal Chemistry, 2004, Zhang, Xue Wu; Yap, Yee Leng
Interaction between fluconazole and amphotericin B in mice with systemic infection due to fluconazole-susceptible or -resistant strains of Candida albicans.
score: 0.94089329, Antimicrobial agents and chemotherapy, 1999, Louie, A et. al.
1-benzazepin-2-one calcium channel blockers—VI. Receptor-binding model and possible relationship to desmethoxyverapamil.
score: 0.94076254, Bioorganic & Medicinal Chemistry, 1993, Kimball, S.David et. al.
Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker
score: 0.94068819, Bioorganic & Medicinal Chemistry Letters, 2001, Dickerson, Tobin J.; Reed, Neal N.; Janda, Kim D.
Haemophilus ducreyi is susceptible to protegrin.
score: 0.94067325, Antimicrobial agents and chemotherapy, 1998, Fortney, K; Totten, P A; Lehrer, R I; Spinola, S M
Tetrazolo[1,5- a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents
score: 0.94065371, European Journal of Medicinal Chemistry, 2004, Bekhit, Adnan A et. al.
Protection against lipopolysaccharide-induced death by fluoroquinolones.
score: 0.94059367, Antimicrobial agents and chemotherapy, 2000, Khan, A A et. al.
1-Substituted pyrazolo[1,5- c]quinazolines as novel Gly/NMDA receptor antagonists: Synthesis, biological evaluation, and molecular modeling study
score: 0.9404675, Bioorganic & Medicinal Chemistry, 2005, Varano, Flavia et. al.
Contribution of topoisomerase IV and DNA gyrase mutations in Streptococcus pneumoniae to resistance to novel fluoroquinolones.
score: 0.94045363, Antimicrobial agents and chemotherapy, 1999, Pestova, E et. al.
CH/π interaction in the conformation of peptides. A database study † † This paper is dedicated to the memory of the late Professor Sir Derek H. R. Barton, the founder of the concept of conformation. The authors sincerely regret the immeasurable loss of an outstanding figure in the world of science.
score: 0.94040198, Bioorganic & Medicinal Chemistry, 1999, Umezawa, Yoji et. al.
Modulation of cyclosporin A/cyclophilin interactions by drug vehicles
score: 0.94033928, Bioorganic & Medicinal Chemistry, 1997, Janowski, Bernhard; Fischer, Gunter
Syntheses and biological evaluation of new glyco-modified angucyclin-antibiotics
score: 0.94032013, Bioorganic & Medicinal Chemistry, 2000, Kirschning, Andreas et. al.
Reduction of no synthase expression and tumor necrosis factor alpha production in macrophages by amphotericin B lipid carriers.
score: 0.94022323, Antimicrobial agents and chemotherapy, 2001, Larabi, M et. al.
Related clones containing SCCmec type IV predominate among clinically significant Staphylococcus epidermidis isolates.
score: 0.94019355, Antimicrobial agents and chemotherapy, 2003, Wisplinghoff, Hilmar et. al.
Practical synthesis of Taxol side chain
score: 0.94009225, Bioorganic & Medicinal Chemistry Letters, 1998, Ha, Hyun-Joon et. al.
Aldose reductase inhibitory effect by tectorigenin derivatives from Viola hondoensis
score: 0.94005291, Bioorganic & Medicinal Chemistry, 2006, Moon, Hyung-In; Jung, Jae-Chul; Lee, Joongku
Ocular distribution of intravenously administered lipid formulations of amphotericin B in a rabbit model.
score: 0.94003083, Antimicrobial agents and chemotherapy, 2002, Goldblum, David et. al.
Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug
score: 0.9397564, Bioorganic & Medicinal Chemistry, 2000, Hanson, Ronald L et. al.
Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates.
score: 0.93963008, Antimicrobial agents and chemotherapy, 2005, Xie, Zhifang; Siddiqi, Noman; Rubin, Eric J
Vancomycin and ceftazidime bioactivities persist for at least 2 weeks in the lumen in ports: simplifying treatment of port-associated bloodstream infections by using the antibiotic lock technique.
score: 0.93961611, Antimicrobial agents and chemotherapy, 2001, Haimi-Cohen, Y et. al.
Comparative in vitro efficacies of various catheter lock solutions.
score: 0.93960689, Antimicrobial agents and chemotherapy, 2006, Sherertz, Robert J et. al.
Synthesis and biological evaluation of 6/7- exo-methyl-3β-(4-iodo)phenyltropane-2β-carboxylic acid methyl esters
score: 0.93959891, European Journal of Medicinal Chemistry, 2005, Airaksinen, Anu J. et. al.
Acetate-mediated growth inhibition in sterol 14alpha-demethylation-deficient cells of Candida albicans.
score: 0.93951611, Antimicrobial agents and chemotherapy, 1999, Shimokawa, O; Nakayama, H
Quantitative structure-activity studies of octopaminergic 2-(Arylimino)thiazolidines and Oxazolidines against the nervous system of Periplaneta americana L.
score: 0.93938258, Bioorganic & Medicinal Chemistry, 1997, Hirashima, Akinori et. al.
Mdt(A), a new efflux protein conferring multiple antibiotic resistance in Lactococcus lactis and Escherichia coli.
score: 0.93915947, Antimicrobial agents and chemotherapy, 2001, Perreten, V; Schwarz, F V; Teuber, M; Levy, S B
Structure–cytotoxic activity relationship for the toad poison bufadienolides
score: 0.93904251, Bioorganic & Medicinal Chemistry, 1998, Kamano, Yoshiaki et. al.
Genetic elements responsible for erythromycin resistance in streptococci.
score: 0.93883904, Antimicrobial agents and chemotherapy, 2009, Varaldo, Pietro E et. al.
Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.
score: 0.93873314, Antimicrobial agents and chemotherapy, 1998, Hafner, R et. al.
Tolerance and pharmacokinetic interactions of rifabutin and azithromycin.
score: 0.93873314, Antimicrobial agents and chemotherapy, 2001, Hafner, R et. al.
Diamine containing VLA-4 antagonists
score: 0.93859802, Bioorganic & Medicinal Chemistry, 2001, Astles, Peter C.; Harris, Neil V.; Morley, Andrew D.
Immunocytochemistry for vancomycin using a monoclonal antibody that reveals accumulation of the drug in rat kidney and liver.
score: 0.93850639, Antimicrobial agents and chemotherapy, 2012, Fujiwara, Kunio et. al.
Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen.
score: 0.93843046, Antimicrobial agents and chemotherapy, 2006, Capitano, Blair et. al.
Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: A chemical model for possible biologically relevant properties of molybdenum-containing enzymes
score: 0.93840277, Bioorganic & Medicinal Chemistry Letters, 2012, Litvić, Mladen et. al.
Efficacy and pharmacokinetics of intravenous nanocapsule formulations of halofantrine in Plasmodium berghei-infected mice.
score: 0.93836261, Antimicrobial agents and chemotherapy, 2004, Mosqueira, Vanessa C F et. al.
The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant
score: 0.93812505, Bioorganic & Medicinal Chemistry, 2002, Brik, Ashraf; Dawson, Philip E; Keinan, Ehud
LYP inhibits T-cell activation when dissociated from CSK.
score: 0.93811511, Nature chemical biology, 2012, Vang, Torkel et. al.
Optimization of Hydrophobic Domains in Peptides that Undergo Transformation from α-Helix to β-Fibril
score: 0.93811074, Bioorganic & Medicinal Chemistry, 1999, Takahashi, Yuta; Ueno, Akihiko; Mihara, Hisakazu
Synthesis of glycosylated β-amino acids as new class of antitubercular agents
score: 0.93799958, European Journal of Medicinal Chemistry, 2002, Tripathi, R.P. et. al.
Transcriptional analyses of antifungal drug resistance in Candida albicans.
score: 0.93795129, Antimicrobial agents and chemotherapy, 2000, Lyons, C N; White, T C
Interaction between artemisinin and heme. A Density Functional Theory study of structures and interaction energies
score: 0.93771455, Bioorganic & Medicinal Chemistry, 2008, Araújo, Jocley Queiroz et. al.
Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants.
score: 0.93770725, Antimicrobial agents and chemotherapy, 1998, Rice, L B
Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors—A review of the triketone chemistry story from a Syngenta perspective
score: 0.93770713, Bioorganic & Medicinal Chemistry, 2009, Beaudegnies, Renaud et. al.
Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of novel pyridine complexes with Zn(II)
score: 0.93768705, European Journal of Medicinal Chemistry, 2010, Gao, En-jun et. al.
Pharmacokinetics of high-dose oseltamivir in healthy volunteers.
score: 0.93752692, Antimicrobial agents and chemotherapy, 2009, Wattanagoon, Y et. al.
Development of a novel targeting system for lethal photosensitization of antibiotic-resistant strains of Staphylococcus aureus.
score: 0.93750037, Antimicrobial agents and chemotherapy, 2005, Embleton, Michelle L et. al.
Diversity of VanA glycopeptide resistance elements in enterococci from humans and nonhuman sources.
score: 0.93746498, Antimicrobial agents and chemotherapy, 1998, Woodford, N; Adebiyi, A M; Palepou, M F; Cookson, B D
Toward Protein-Cleaving Catalytic Drugs: Artificial Protease Selective for Myoglobin
score: 0.93741954, Bioorganic & Medicinal Chemistry, 2003, Jeon, Joong Won et. al.
Mutation in the sdeS gene promotes expression of the sdeAB efflux pump genes and multidrug resistance in Serratia marcescens.
score: 0.93736569, Antimicrobial agents and chemotherapy, 2011, Maseda, Hideaki et. al.
Highly regioselective synthesis of N-3 organophosphorous derivatives of 3,4-dihydropyrimidin-2(1H)-ones and their calcium channel binding studies
score: 0.93729756, European Journal of Medicinal Chemistry, 2012, Singh, Kamaljit et. al.
Synthesis of anticancer β-lactams: mechanism of action
score: 0.93727611, Bioorganic & Medicinal Chemistry, 2004, Banik, Bimal K.; Becker, Frederick F.; Banik, Indrani
Labeling, characterization, and in vivo localization of a new 90Y-based phosphonate chelate 2,3-dicarboxypropane-1,1-diphosphonic acid for the treatment of bone metastases: Comparison with 99mTc–DPD complex
score: 0.9372579, Bioorganic & Medicinal Chemistry, 2008, Djokić, Divna Dj.; Janković, Drina Lj.; Nikolić, Nadežda S.
Pharmacokinetics of oral valganciclovir and intravenous ganciclovir administered to prevent cytomegalovirus disease in an adult patient receiving small-intestine transplantation.
score: 0.93692046, Antimicrobial agents and chemotherapy, 2004, Fortún Abete, Jesús et. al.
MarA-like regulator of multidrug resistance in Yersinia pestis.
score: 0.93680962, Antimicrobial agents and chemotherapy, 2006, Udani, Rupa A; Levy, Stuart B
Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: results from a randomized, controlled clinical trial. Collaborative Antiviral Study Group/AIDS Clinical Trials Group, Herpes Zoster Study Group.
score: 0.93673972, Antimicrobial agents and chemotherapy, 1998, Gnann, J W et. al.
Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.
score: 0.93671996, Antimicrobial agents and chemotherapy, 2009, Sánchez-Cañete, María P et. al.
Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro.
score: 0.93669707, Antimicrobial agents and chemotherapy, 1998, Kawasaki, S et. al.
Redox-changes associated with the glutathione-dependent ability of the Cu(II)-GSSG complex to generate superoxide
score: 0.9366347, Bioorganic & Medicinal Chemistry, 2012, Aliaga, Margarita E. et. al.
T cell monitoring of chemotherapy in experimental rat tuberculosis.
score: 0.93662261, Antimicrobial agents and chemotherapy, 2011, Foo, Damian Guang et. al.
Antiviral cyclic d, l-α-peptides: Targeting a general biochemical pathway in virus infections
score: 0.93660405, Bioorganic & Medicinal Chemistry, 2005, Horne, W. Seth et. al.
Isolation and Synthesis of Two Antiproliferative Calamenene-type Sesquiterpenoids from Sterculia capuronii from the Madagascar Rain Forest
score: 0.93659809, Bioorganic & Medicinal Chemistry, 2012, Dai, Yumin et. al.
Synthesis, characterisation, activities, cell uptake and DNA binding of a trinuclear complex: [{ trans-PtCl(NH 3)} 2μ-{ trans-Pd(NH 3)(2-hydroxypyridine)-(H 2N(CH 2) 6NH 2) 2]Cl 4
score: 0.93654967, European Journal of Medicinal Chemistry, 2006, Cheng, H.; Huq, F.; Beale, P.; Fisher, K.
Development of an allele-specific PCR for detection of the K65R resistance mutation in patients infected with subtype C human immunodeficiency virus type 1.
score: 0.93654012, Antimicrobial agents and chemotherapy, 2010, Toni, Thomas A et. al.
Preparation and use of a photoactivatable glucose-6-phosphate analogue
score: 0.93646562, Bioorganic & Medicinal Chemistry Letters, 2000, Peng, Jirong et. al.
Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C.
score: 0.93628672, Antimicrobial agents and chemotherapy, 2009, Yee, Leland J et. al.
Alginate lyase promotes diffusion of aminoglycosides through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa.
score: 0.93627712, Antimicrobial agents and chemotherapy, 1998, Hatch, R A; Schiller, N L
Preparation of soluble and insoluble polymer supported IBX reagents
score: 0.93622436, Bioorganic & Medicinal Chemistry Letters, 2002, Reed, Neal N et. al.
Antifungal susceptibilities of Paecilomyces species.
score: 0.93609276, Antimicrobial agents and chemotherapy, 1998, Aguilar, C; Pujol, I; Sala, J; Guarro, J
Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections.
score: 0.93587219, Antimicrobial agents and chemotherapy, 2011, Ahmad, Zahoor et. al.
Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans.
score: 0.93582024, Antimicrobial agents and chemotherapy, 2005, Etuaful, S et. al.
In vitro and in vivo activities of arachidonic acid against Schistosoma mansoni and Schistosoma haematobium.
score: 0.93576091, Antimicrobial agents and chemotherapy, 2010, El Ridi, Rashika et. al.
Preparation of N- t Boc l-glutathione dimethyl and di- tert-butyl esters: Versatile synthetic building blocks
score: 0.93575314, Bioorganic & Medicinal Chemistry, 2007, Falck, J.R.; Sangras, Bhavani; Capdevila, Jorge H.
The use of ‘electronic nose’ sensor responses to predict the inhibition activity of alcohols on the cytochrome P-450 catalyzed p-hydroxylation of aniline
score: 0.93571158, Bioorganic & Medicinal Chemistry, 2000, Vaid, Thomas P; Lewis, Nathan S
Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study.
score: 0.93565762, Antimicrobial agents and chemotherapy, 1999, McDowell, J A et. al.
A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium).
score: 0.93564955, Antimicrobial agents and chemotherapy, 2001, Koutsolioutsou, A et. al.
Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX
score: 0.93563816, European Journal of Medicinal Chemistry, 2006, Calderone, Vincenzo et. al.
Ribonucleic guanidine demonstrates an unexpected marked preference for complementary DNA rather than RNA
score: 0.9355622, Bioorganic & Medicinal Chemistry, 2006, Park, Myunji; Toporowski, Joseph W.; Bruice, Thomas C.
Synthesis and biological evaluation of deoxy salacinols, the role of polar substituents in the side chain on the α-glucosidase inhibitory activity
score: 0.93554929, Bioorganic & Medicinal Chemistry, 2006, Muraoka, Osamu et. al.
Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.
score: 0.93549543, Antimicrobial agents and chemotherapy, 2003, Sanglard, Dominique et. al.
Micafungin enhances neutrophil fungicidal functions against Candida pseudohyphae.
score: 0.93527869, Antimicrobial agents and chemotherapy, 2004, Gil-Lamaignere, Cristina et. al.
In vitro susceptibilities of the microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to albendazole and its sulfoxide and sulfone metabolites.
score: 0.93526932, Antimicrobial agents and chemotherapy, 1998, Ridoux, O; Drancourt, M
Pharmacokinetics and safety profile of the human anti-Pseudomonas aeruginosa serotype O11 immunoglobulin M monoclonal antibody KBPA-101 in healthy volunteers.
score: 0.93519832, Antimicrobial agents and chemotherapy, 2009, Lazar, Hedvika et. al.
Effect of glycine on Helicobacter pylori in vitro.
score: 0.9351123, Antimicrobial agents and chemotherapy, 2004, Minami, Masaaki et. al.
Rapid photolytic release of cytidine 5′-diphosphate from a coumarin derivative: a new tool for the investigation of ribonucleotide reductases
score: 0.93510819, Bioorganic & Medicinal Chemistry, 2002, Schönleber, Ralph O et. al.
Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams.
score: 0.93509283, Antimicrobial agents and chemotherapy, 2003, Nishino, Kunihiko et. al.
Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys.
score: 0.93502812, Antimicrobial agents and chemotherapy, 2000, Manson, K H; Wyand, M S; Miller, C; Neurath, A R
Retraction notice to “Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrug of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease” [European Journal of Medicinal Chemistry 42 (2006) 885–890]
score: 0.93493397, European Journal of Medicinal Chemistry, 2008, Dhaneshwar, Suneela S. et. al.
Lanthanide-based fluorogenic peptide substrate for the highly sensitive detection of thermolysin
score: 0.93485015, Bioorganic & Medicinal Chemistry Letters, 2009, Marguerre, Ann-Kathrin; Krämer, Roland
Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes
score: 0.93480966, European Journal of Medicinal Chemistry, 2012, Yin, Handong et. al.
Effect of unsaturation in fatty acids on the binding and oxidation by myeloperoxidase: Ramifications for the initiation of atherosclerosis
score: 0.93467533, Bioorganic & Medicinal Chemistry Letters, 2010, Clark, Amanda L.; Matera, Kathryn Mansfield
The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.
score: 0.93464811, Antimicrobial agents and chemotherapy, 2002, Pradel, Elizabeth; Pagès, Jean-Marie
Access to the inaccessible sequence of Cpn 60.1 (195–217) by temporary oxazolidine protection of selected amide bonds
score: 0.93458289, Bioorganic & Medicinal Chemistry Letters, 2001, Keller, Michael; Miller, Andrew D.
Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs.
score: 0.934563, Antimicrobial agents and chemotherapy, 2004, Dumitru, Raluca; Hornby, Jacob M; Nickerson, Kenneth W
Pharmacokinetics of telbivudine in healthy subjects and absence of drug interaction with lamivudine or adefovir dipivoxil.
score: 0.93440896, Antimicrobial agents and chemotherapy, 2006, Zhou, Xiao-Jian et. al.
Safety and efficacy of moxifloxacin monotherapy for treatment of orthopedic implant-related staphylococcal infections.
score: 0.93439259, Antimicrobial agents and chemotherapy, 2010, San Juan, Rafael et. al.
Chromatin as an expansive canvas for chemical biology.
score: 0.93428217, Nature chemical biology, 2012, Fierz, Beat; Muir, Tom W
Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.
score: 0.93427022, Antimicrobial agents and chemotherapy, 2010, Sissi, C et. al.
Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold
score: 0.93426097, Bioorganic & Medicinal Chemistry, 2012, Gomaa, Mohamed S. et. al.
Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold
score: 0.93426097, Bioorganic & Medicinal Chemistry, 2012, Gomaa, Mohamed S. et. al.
Both a protective and a deleterious role for the L76V mutation.
score: 0.93409356, Antimicrobial agents and chemotherapy, 2009, Tartaglia, Alessandra et. al.
Synthesis, spectroscopic characterization and biological properties of new natural aldehydes thiosemicarbazones
score: 0.93406054, Bioorganic & Medicinal Chemistry, 2000, Tarasconi, Pieralberto et. al.
The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate
score: 0.93402882, Bioorganic & Medicinal Chemistry Letters, 2006, Żesławska, Ewa et. al.
Pharmacokinetic evaluation of amphotericin B in lung tissue: lung lymph distribution after intravenous injection and airspace distribution after aerosolization and inhalation of amphotericin B.
score: 0.93400975, Antimicrobial agents and chemotherapy, 1998, Koizumi, T et. al.
In vitro activities of 5-fluorocytosine against 8,803 clinical isolates of Candida spp.: global assessment of primary resistance using National Committee for Clinical Laboratory Standards susceptibility testing methods.
score: 0.93400775, Antimicrobial agents and chemotherapy, 2002, Pfaller, M A et. al.
Antibacterial efficacy of temperate phage-mediated inhibition of bacterial group motilities.
score: 0.93399906, Antimicrobial agents and chemotherapy, 2012, Chung, In-Young; Sim, Nuri; Cho, You-Hee
TETA analogue containing one methylenephosphonate pendant arm: Lanthanide complexes and biological evaluation of its 153Sm and 166Ho complexes
score: 0.93393828, European Journal of Medicinal Chemistry, 2010, Lima, Luís M.P. et. al.
Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity
score: 0.93370718, European Journal of Medicinal Chemistry, 2006, Colombo, Diego et. al.
An organoselenium compound inhibits Staphylococcus aureus biofilms on hemodialysis catheters in vivo.
score: 0.93359913, Antimicrobial agents and chemotherapy, 2012, Tran, Phat L et. al.
Rethinking screening.
score: 0.93356491, Nature chemical biology, 2010, Kodadek, Thomas
New model of oropharyngeal candidiasis in mice.
score: 0.93351722, Antimicrobial agents and chemotherapy, 2001, Kamai, Y et. al.
Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5' nuclease real-time PCR.
score: 0.93351608, Antimicrobial agents and chemotherapy, 2005, Hamasuna, Ryoichi; Osada, Yukio; Jensen, Jørgen Skov
Ambulatory treatment of multidrug-resistant Staphylococcus-infected orthopedic implants with high-dose oral co-trimoxazole (trimethoprim-sulfamethoxazole).
score: 0.93348617, Antimicrobial agents and chemotherapy, 1998, Stein, A et. al.
Quinolinotriazole-β-cyclodextrin and its adamantanecarboxylic acid complex as efficient water-soluble fluorescent Cd 2+ sensors
score: 0.9332945, Bioorganic & Medicinal Chemistry, 2010, Zhang, Ying-Ming et. al.
Alkylidene branched lupane derivatives: Synthesis and antitumor activity
score: 0.93319144, European Journal of Medicinal Chemistry, 2012, Csuk, René et. al.
Risk factors for fecal quinolone-resistant Escherichia coli in Mexican children.
score: 0.93315747, Antimicrobial agents and chemotherapy, 2003, Zaidi, Mussaret B et. al.
Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-Targeted anticancer drugs
score: 0.93309589, Bioorganic & Medicinal Chemistry, 2002, Spicer, Julie A et. al.
Synthesis and anticonvulsant activity of enaminones.
score: 0.93309291, European Journal of Medicinal Chemistry, 2002, Eddington, Natalie D et. al.
Experimental bacteriophage therapy increases survival of Galleria mellonella larvae infected with clinically relevant strains of the Burkholderia cepacia complex.
score: 0.93290541, Antimicrobial agents and chemotherapy, 2009, Seed, Kimberley D; Dennis, Jonathan J
Enteroviral meningitis: natural history and outcome of pleconaril therapy.
score: 0.93287592, Antimicrobial agents and chemotherapy, 2006, Desmond, R A et. al.
A short and efficient synthesis of 4-[2,2-dimethyl-4(tol-4-yl)benzochrom-3-en-7-yl]benzoic acid - a potent retinoic acid receptor antagonist
score: 0.9328431, Bioorganic & Medicinal Chemistry Letters, 1999, Vuligonda, Vidyasagar; Chandraratna, Roshantha A.S.
Phase II Dose Escalation Study of Caspofungin for Invasive Aspergillosis.
score: 0.93280904, Antimicrobial agents and chemotherapy, 2011, Cornely, O A et. al.
Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII
score: 0.93276278, European Journal of Medicinal Chemistry, 2005, Calderone, Vincenzo et. al.
Garbled messages and corrupted translations.
score: 0.93276254, Nature chemical biology, 2010, Schneider-Poetsch, Tilman et. al.
Interpretation of genotype and pharmacokinetics for resistance to fosamprenavir-ritonavir-based regimens in antiretroviral-experienced patients.
score: 0.93268236, Antimicrobial agents and chemotherapy, 2007, Pellegrin, Isabelle et. al.
A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor
score: 0.93266278, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Min et. al.
A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor
score: 0.93266278, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Min et. al.
A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor
score: 0.93266278, Bioorganic & Medicinal Chemistry Letters, 2012, Wang, Min et. al.
Small Molecule Proteostasis Regulators for Protein Conformational Diseases
score: 0.93231569, Nature Chemical Biology, 2011, Calamini, Barbara et. al.
Pharmacokinetics of DA-7867, a new oxazolidinone, after intravenous or oral administration to rats: intestinal first-pass effect.
score: 0.93226459, Antimicrobial agents and chemotherapy, 2004, Bae, Soo K et. al.
Structure determination of metabolites isolated from urine and bile after administration of AY4166, a novel d-phenylalanine-derivative hypoglycemic agent
score: 0.93208337, Bioorganic & Medicinal Chemistry, 1996, Takesada, Hiroko et. al.
RNA interference with 2′,4′-bridged nucleic acid analogues
score: 0.93181, Bioorganic & Medicinal Chemistry, 2010, Abdur Rahman, S.M. et. al.
Synergistic Effect of Thermal Energy on Bactericidal Action of Photolysis of H2O2 in Relation to Acceleration of Hydroxyl Radical Generation.
score: 0.93175504, Antimicrobial agents and chemotherapy, 2012, Shirato, Midori et. al.
Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases
score: 0.93173276, European Journal of Medicinal Chemistry, 2010, Liu, Zeng-Chen et. al.
Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations.
score: 0.93156437, Antimicrobial agents and chemotherapy, 2012, Lu, Yanhui et. al.
Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis
score: 0.93141159, European Journal of Medicinal Chemistry, 2012, Ilić, Miloš et. al.
Acyclovir for treatment of postherpetic neuralgia: efficacy and pharmacokinetics.
score: 0.93140711, Antimicrobial agents and chemotherapy, 2001, Acosta, E P; Balfour, H H
In vitro antimycoplasmal activity of citrus bergamia essential oil and its major components
score: 0.93131209, European Journal of Medicinal Chemistry, 2012, Furneri, Pio Maria et. al.
New aromatic iminoimidazolidine derivatives as α 1-adrenoceptor antagonists: a novel synthetic approach and pharmacological activity
score: 0.93130531, Bioorganic & Medicinal Chemistry, 2000, Dardonville, Christophe et. al.
Synthesis, radiosynthesis and In vivo evaluation of 5-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[ 11C]one, as a potent NR 1A/2B subtype selective NMDA PET radiotracer
score: 0.93122109, Bioorganic & Medicinal Chemistry, 2003, Roger, Gaëlle et. al.
18F-FBHGal for asialoglycoprotein receptor imaging in a hepatic fibrosis mouse model
score: 0.93115258, Bioorganic & Medicinal Chemistry, 2013, Kao, Hao-Wen et. al.
Physicochemical properties of quinolone antibiotics in various environments
score: 0.93105243, European Journal of Medicinal Chemistry, 2002, Park, Hyoung-Ryun; Kim, Tae Heung; Bark, Ki-Min
Histones accelerate the cyclic 1, N 2-propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde
score: 0.93104415, Bioorganic & Medicinal Chemistry Letters, 2003, Sako, Magoichi et. al.
Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES
score: 0.93097703, Bioorganic & Medicinal Chemistry, 2002, Nishiyama, Yasuhiro et. al.
N 6-Cycloalkyl-2-phenyl-3-deaza-8-azaadenines: a new class of A 1 adenosine receptor ligands. A comparison with the corresponding adenines and 8-azaadenines
score: 0.93073559, European Journal of Medicinal Chemistry, 2003, Biagi, Giuliana et. al.
Impact of alpha interferon and ribavirin on the function of maturing dendritic cells.
score: 0.93073378, Antimicrobial agents and chemotherapy, 2004, Barnes, Eleanor et. al.
Binding partners for curcumin in human schwannoma cells: Biologic Implications
score: 0.9306066, Bioorganic & Medicinal Chemistry, 2013, Angelo, Laura S. et. al.
Fluorescent ε-ATP analogues for probing physicochemical properties of proteins. Synthesis, biochemical evaluation, and sensitivity to properties of the medium
score: 0.93060167, Bioorganic & Medicinal Chemistry, 2004, Sharon, Einat et. al.
Biotransformations with Rhizopus arrhizus and Geotrichum candidum for the preparation of ( S)-Atenolol and ( S)-Propranolol
score: 0.93053074, Bioorganic & Medicinal Chemistry, 2000, Damle, Subhash V; Patil, Prashant N; Salunkhe, Manikrao M
Epicubenol synthase. Origin of the oxygen atom of a bacterial sesquiterpene alcohol
score: 0.93052321, Bioorganic & Medicinal Chemistry Letters, 2000, Cane, David E.; Ke, Ning
Medium sized lactones with hypolipidaemic and antioxidant activity: synthesis and biological evaluation of promising dual-action anti-atherosclerosis drugs
score: 0.93050528, Bioorganic & Medicinal Chemistry, 1999, Baldazzi, Claudia et. al.
In vitro activities of gemifloxacin (SB 265805, LB20304) against recent clinical isolates of Chlamydia pneumoniae.
score: 0.9304294, Antimicrobial agents and chemotherapy, 1999, Roblin, P M; Reznik, T; Kutlin, A; Hammerschlag, M R
High levels of antimicrobial coresistance among extended-spectrum-beta-lactamase-producing Enterobacteriaceae.
score: 0.93036633, Antimicrobial agents and chemotherapy, 2005, Schwaber, Mitchell J et. al.
Synthesis and initial tumor affinity testing of iodine-123 labelled EGFR-affine agents as potential imaging probes for hormone-refractory prostate cancer
score: 0.9298629, European Journal of Medicinal Chemistry, 2010, Fozing, Thierry; Scheuer, Claudia; Samnick, Samuel
Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine
score: 0.92977121, Bioorganic & Medicinal Chemistry, 2004, Bareich, David et. al.
Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin.
score: 0.92969097, Antimicrobial agents and chemotherapy, 2003, Schmutz, Elisabeth et. al.
Synthesis, characterization, and anti-bacterial efficacy of some novel cyclophane amide
score: 0.92962588, Bioorganic & Medicinal Chemistry, 2006, Rajakumar, Perumal et. al.
Influence of VanD type resistance on activities of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecium.
score: 0.92959042, Antimicrobial agents and chemotherapy, 2003, Lefort, Agnès et. al.
The cell adhesion and proliferation activities of a peptide derived from human tenascin-C are dependent on two Ile residues
score: 0.92937761, Bioorganic & Medicinal Chemistry, 2012, Hayashi, Ryo et. al.
Differences in the Frequency of 23S rRNA Gene Mutations in Mycoplasma pneumoniae between Children and Adults with Community-Acquired Pneumonia: Clinical Impact of Mutations Conferring Macrolide Resistance.
score: 0.92934279, Antimicrobial agents and chemotherapy, 2012, Yoo, Soo Jin et. al.
A tetracycline-binding RNA aptamer
score: 0.92933077, Bioorganic & Medicinal Chemistry, 2001, Berens, Christian; Thain, Alison; Schroeder, Renée
8-Methylureido-10-amino-10-methyl-imidazo[1,2- a]indeno[1,2- e]pyrazine-4-ones: Highly In vivo Potent and Selective AMPA Receptor Antagonists
score: 0.92929013, Bioorganic & Medicinal Chemistry, 2000, Jimonet, Patrick et. al.
Prevalence of protease and reverse transcriptase drug resistance mutations over time in drug-naïve human immunodeficiency virus type 1-positive individuals in Rio de Janeiro, Brazil.
score: 0.92915394, Antimicrobial agents and chemotherapy, 2002, Dumans, Ana T et. al.
Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors
score: 0.92901605, European Journal of Medicinal Chemistry, 2006, de Souza, Aparecido Ribeiro et. al.
Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles
score: 0.92891049, European Journal of Medicinal Chemistry, 2002, Andrzejewska, Mariola et. al.
An axenic amastigote system for drug screening.
score: 0.92881175, Antimicrobial agents and chemotherapy, 1997, Callahan, H L; Portal, A C; Devereaux, R; Grogl, M
LUMO energy of model compounds of bispyridinium compounds as an index for the inhibition of choline kinase
score: 0.92859174, European Journal of Medicinal Chemistry, 2001, Campos, Joaquı́n et. al.
Synthesis and reactivity studies on new copper(II) complexes: DNA binding, generation of phenoxyl radical, SOD and nuclease activities
score: 0.92858194, European Journal of Medicinal Chemistry, 2010, Ghosh, Kaushik et. al.
Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5′-ends
score: 0.92851675, Bioorganic & Medicinal Chemistry, 2000, Sengle, Gerhard et. al.
Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(–) and S(+)-2-α-hydroxybenzylbenzimidazole) 2Cl 2] complexes
score: 0.92835105, European Journal of Medicinal Chemistry, 2005, Gökçe, M.; Utku, S.; Gür, S.; Özkul, A.; Gümüş, F.
Zinc(II) and copper(II) complexes of β-substituted hydroxylporphyrins as tumor photosensitizers
score: 0.92820723, Bioorganic & Medicinal Chemistry Letters, 2006, Huang, Qimao et. al.
Searching for allosteric effects via QSARs
score: 0.92815146, Bioorganic & Medicinal Chemistry, 2001, Hansch, Corwin; Garg, Rajni; Kurup, Alka
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.
score: 0.92809515, Antimicrobial agents and chemotherapy, 2005, McCammon, Mark T et. al.
Studies on the mode of action of the antifungal hexapeptide PAF26.
score: 0.92798238, Antimicrobial agents and chemotherapy, 2006, Muñoz, Alberto; López-García, Belén; Marcos, Jose F
Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda.
score: 0.92780501, Antimicrobial agents and chemotherapy, 2011, Baliraine, Frederick N et. al.
The virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner.
score: 0.92771264, Antimicrobial agents and chemotherapy, 2010, Bultmann, Hermann et. al.
Nucleotide sequence of the bla(RTG-2) (CARB-5) gene and phylogeny of a new group of carbenicillinases.
score: 0.92767562, Antimicrobial agents and chemotherapy, 2000, Choury, D et. al.
Two novel antibiotics, Sch 419558 and Sch 419559, produced by Pseudomonas fluorescens: effect on activity by overexpression of RpoE
score: 0.92751624, Bioorganic & Medicinal Chemistry, 2004, Yang, Shu-Wei et. al.
Reduced efficacy of intermittent preventive treatment of malaria in malnourished children.
score: 0.92745746, Antimicrobial agents and chemotherapy, 2009, Danquah, Ina et. al.
Selective binding of coumarin enantiomers to human α 1-acid glycoprotein genetic variants
score: 0.92739504, Bioorganic & Medicinal Chemistry, 2006, Hazai, Eszter et. al.
Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure–activity relationships underpinning their anti-proliferative and chelation efficacy
score: 0.92720076, Bioorganic & Medicinal Chemistry Letters, 2013, Lukmantara, Adeline Y. et. al.
Bactericidal activities of milk lipids.
score: 0.92710087, Antimicrobial agents and chemotherapy, 2001, Sprong, R C; Hulstein, M F; Van der Meer, R
Design and syntheses of putative bioactive taxanes
score: 0.92708482, Bioorganic & Medicinal Chemistry, 2002, Nikolakakis, Anastasia et. al.
Population pharmacokinetics of piperacillin at two dose levels: influence of nonlinear pharmacokinetics on the pharmacodynamic profile.
score: 0.92691683, Antimicrobial agents and chemotherapy, 2012, Landersdorfer, Cornelia B et. al.
A novel peptide-grafted liposomal delivery system targeted to macrophages.
score: 0.92683346, Antimicrobial agents and chemotherapy, 1998, Banerjee, G; Medda, S; Basu, M K
Double-blind evaluation of the safety and pharmacokinetics of multiple oral once-daily 750-milligram and 1-gram doses of levofloxacin in healthy volunteers.
score: 0.92678524, Antimicrobial agents and chemotherapy, 1998, Chien, S C et. al.
Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infection.
score: 0.92655768, Antimicrobial agents and chemotherapy, 2002, Lewis, Russell E et. al.
Properties of flaky affinity resin with co-continuous structure
score: 0.92649308, Bioorganic & Medicinal Chemistry, 2008, Mori, Tomoko et. al.
Lipase catalyzed synthesis of benzyl acetate in solvent-free medium using vinyl acetate as acyl donor
score: 0.92624011, Bioorganic & Medicinal Chemistry Letters, 2006, Majumder, Abir B. et. al.
Synthesis of peptide aldehydes via enzymatic acylation of amino aldehyde derivatives
score: 0.92622207, Bioorganic & Medicinal Chemistry, 1999, Voyushina, Tatiana L. et. al.
Corrigendum to “Design, synthesis and SAR studies of 4-allyoxyaniline amides as potent 15-lipoxygensae inhibitors” [Bioorg. Med. Chem. 17 (2009) 1614]
score: 0.92618124, Bioorganic & Medicinal Chemistry, 2010, Seyedi, Seyed Mohammad et. al.
Anti-HIV natural product (+)-calanolide A is active against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis
score: 0.92556871, Bioorganic & Medicinal Chemistry, 2004, Xu, Ze-Qi et. al.
Characterization of the MexC-MexD-OprJ multidrug efflux system in DeltamexA-mexB-oprM mutants of Pseudomonas aeruginosa.
score: 0.92554, Antimicrobial agents and chemotherapy, 1998, Gotoh, N et. al.
Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.
score: 0.92553769, Antimicrobial agents and chemotherapy, 2004, Kern, Earl R et. al.
Large flanking sequence effects in single nucleotide mismatch detection using fluorescent nucleoside Ç f
score: 0.92515114, Bioorganic & Medicinal Chemistry, 2010, Gardarsson, Haraldur; Sigurdsson, Snorri Th.
Dendrimers as potential drug carriers. Part II. Prolonged delivery of ketoprofen by in vitro and in vivo studies
score: 0.92513465, European Journal of Medicinal Chemistry, 2006, Na, Man et. al.
Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults.
score: 0.9250983, Antimicrobial agents and chemotherapy, 2006, Ma, Joseph D et. al.
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.
score: 0.9250904, Antimicrobial agents and chemotherapy, 2006, Gilgado, Fèlix et. al.
Electronic detection of DNA mutation based on strand exchange reaction
score: 0.92494256, Bioorganic & Medicinal Chemistry, 2009, Watanabe, Mariko et. al.
Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.
score: 0.92492056, Antimicrobial agents and chemotherapy, 2004, Azoulay-Dupuis, E et. al.
Adaptation and antibiotic tolerance of anaerobic Burkholderia pseudomallei.
score: 0.92485038, Antimicrobial agents and chemotherapy, 2011, Hamad, Mohamad A et. al.
Synthesis and antiproliferative activity of 2,6-Dibenzylamino-3,5-dicyanopyridines on human cancer cell lines
score: 0.92475576, European Journal of Medicinal Chemistry, 2005, Cocco, Maria Teresa et. al.
The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells.
score: 0.924677, Antimicrobial agents and chemotherapy, 2009, Mendez, Susana et. al.
Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides.
score: 0.92457361, Antimicrobial agents and chemotherapy, 2009, Sonza, Secondo et. al.
New Bis-catechols 5-lipoxygenase inhibitors
score: 0.92438293, Bioorganic & Medicinal Chemistry, 2001, Dupont, Romain et. al.
A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin
score: 0.92433847, Bioorganic & Medicinal Chemistry Letters, 2003, Wanner, Jutta et. al.
Tn2009, a Tn916-like element containing mef(E) in Streptococcus pneumoniae.
score: 0.92427922, Antimicrobial agents and chemotherapy, 2004, Del Grosso, Maria et. al.
Population pharmacokinetics and pharmacodynamic modeling of abacavir (1592U89) from a dose-ranging, double-blind, randomized monotherapy trial with human immunodeficiency virus-infected subjects.
score: 0.92417438, Antimicrobial agents and chemotherapy, 2000, Weller, S; Radomski, K M; Lou, Y; Stein, D S
Single-dose AmBisome (Liposomal amphotericin B) as prophylaxis for murine systemic candidiasis and histoplasmosis.
score: 0.92416078, Antimicrobial agents and chemotherapy, 2000, Garcia, A; Adler-Moore, J P; Proffitt, R T
DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases
score: 0.92413403, Bioorganic & Medicinal Chemistry, 2012, San Pedro, Joanna Maria N. et. al.
The electricidal effect: reduction of Staphylococcus and pseudomonas biofilms by prolonged exposure to low-intensity electrical current.
score: 0.92412458, Antimicrobial agents and chemotherapy, 2009, del Pozo, Jose L et. al.
Interaction of antimicrobial peptide temporin L with lipopolysaccharide in vitro and in experimental rat models of septic shock caused by gram-negative bacteria.
score: 0.92402392, Antimicrobial agents and chemotherapy, 2006, Giacometti, Andrea et. al.
Effect of melanin on netilmicin-induced inhibition of collagen biosynthesis in human skin fibroblasts
score: 0.9239947, Bioorganic & Medicinal Chemistry, 2006, Buszman, Ewa et. al.
Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.
score: 0.9237698, Antimicrobial agents and chemotherapy, 2000, Giacometti, A et. al.
Heterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles
score: 0.92372187, European Journal of Medicinal Chemistry, 2006, Mathew, V.; Keshavayya, J.; Vaidya, V.P.
Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potentialantidepressant drugs
score: 0.92365812, Bioorganic & Medicinal Chemistry, 1999, Corral, Carlos et. al.
Pharmacokinetics of ethionamide in children.
score: 0.92363172, Antimicrobial agents and chemotherapy, 2011, Thee, S et. al.
Pharmacokinetics of levofloxacin and ciprofloxacin during continuous renal replacement therapy in critically ill patients.
score: 0.92359501, Antimicrobial agents and chemotherapy, 2001, Malone, R S; Fish, D N; Abraham, E; Teitelbaum, I
The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro.
score: 0.92340256, Antimicrobial agents and chemotherapy, 2002, Bowman, J C et. al.
In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron.
score: 0.92336984, Antimicrobial agents and chemotherapy, 2001, Pradines, B et. al.
Corrugoside, a new immunostimulatory α-galactoglycosphingolipid from the marine sponge Axinella corrugata
score: 0.92332764, Bioorganic & Medicinal Chemistry, 2008, Costantino, Valeria et. al.
Synthesis of some new biologically active 1,3,4-oxadiazolyl nitroindoles and a modified Fischer indole synthesis of ethyl nitro indole-2-carboxylates
score: 0.92331278, Bioorganic & Medicinal Chemistry, 2005, Narayana, B. et. al.
Trovafloxacin treatment of viridans group Streptococcus experimental endocarditis.
score: 0.92327747, Antimicrobial agents and chemotherapy, 2000, Piper, K E et. al.
The chemoenzymatic synthesis of usnic acid
score: 0.92323672, Bioorganic & Medicinal Chemistry Letters, 2009, Hawranik, Drew J. et. al.
A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.
score: 0.92314014, Antimicrobial agents and chemotherapy, 2012, Fang, Yue et. al.
Small-molecule inhibition of APT1 affects Ras localization and signaling.
score: 0.92305257, Nature chemical biology, 2010, Dekker, Frank J et. al.
Nevirapine exposure with WHO pediatric weight band dosing: enhanced therapeutic concentrations predicted based on extensive international pharmacokinetic experience.
score: 0.92294987, Antimicrobial agents and chemotherapy, 2012, Nikanjam, Mina et. al.
Pharmacokinetics and absolute bioavailability of oral foscarnet in human immunodeficiency virus-seropositive patients.
score: 0.92290533, Antimicrobial agents and chemotherapy, 1998, Noormohamed, F H et. al.
Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapy.
score: 0.9227835, Antimicrobial agents and chemotherapy, 2005, Jullien, Vincent et. al.
Pharmacokinetic and pharmacodynamic evaluation of liposomal amikacin for inhalation in cystic fibrosis patients with chronic pseudomonal infection.
score: 0.92276342, Antimicrobial agents and chemotherapy, 2009, Okusanya, Olanrewaju O et. al.
Piperacillin and tazobactam exhibit linear pharmacokinetics after multiple standard clinical doses.
score: 0.92270286, Antimicrobial agents and chemotherapy, 1999, Auclair, B; Ducharme, M P
Interaction of the Echinocandin Caspofungin with Amphotericin B or Voriconazole against Aspergillus Biofilms In Vitro.
score: 0.92269482, Antimicrobial agents and chemotherapy, 2012, Liu, Weixia et. al.
Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands
score: 0.92250315, European Journal of Medicinal Chemistry, 2001, Imming, Peter et. al.
Transferable vanB2 Tn5382-containing elements in fecal streptococcal strains from veal calves.
score: 0.92241749, Antimicrobial agents and chemotherapy, 2003, Dahl, Kristin H; Sundsfjord, Arnfinn
Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus.
score: 0.92239484, Antimicrobial agents and chemotherapy, 2004, Tahlan, Kapil et. al.
Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates.
score: 0.92231105, Antimicrobial agents and chemotherapy, 2009, Hirt, Déborah et. al.
Induction of apoptosis in HeLa cells by 3β-hydroxy-12-oleanen-27-oic acid from the rhizomes of Astilbe chinensis
score: 0.92230301, Bioorganic & Medicinal Chemistry, 2006, Sun, Hong-Xiang; Zheng, Quan-Fang; Tu, Jue
Induction of antimalaria immunity by pyrimethamine prophylaxis during exposure to sporozoites is curtailed by parasite resistance.
score: 0.92219062, Antimicrobial agents and chemotherapy, 2011, Friesen, Johannes; Borrmann, Steffen; Matuschewski, Kai
Amino- and glycoconjugates of pyrido[4,3,2- kl]acridine. Synthesis, antitumor activity, and DNA binding
score: 0.92209155, Bioorganic & Medicinal Chemistry, 2006, Bouffier, Laurent et. al.
In vitro trafficking and efficacy of core-shell nanostructures for treating intracellular Salmonella infections.
score: 0.92195223, Antimicrobial agents and chemotherapy, 2009, Ranjan, A et. al.
Improving the affinity of naphthalene diimide ligand to telomeric DNA by incorporating Zn2+ ions into its dipicolylamine groups
score: 0.92193453, Bioorganic & Medicinal Chemistry, 2012, Czerwinska, Izabella; Sato, Shinobu; Takenaka, Shigeori
Improving the affinity of naphthalene diimide ligand to telomeric DNA by incorporating Zn2+ ions into its dipicolylamine groups
score: 0.92193453, Bioorganic & Medicinal Chemistry, 2012, Czerwinska, Izabella; Sato, Shinobu; Takenaka, Shigeori
The synthesis of ( R)-(+)-lipoic acid using a monooxygenase-catalysed biotransformation as the key step
score: 0.92182847, Bioorganic & Medicinal Chemistry, 1997, Adger, Brian et. al.
Observations on the covalent cross-linking of the binding domain (BD) of the high mobility group I/Y (HMG I/Y) proteins to DNA by FR66979
score: 0.92177131, Bioorganic & Medicinal Chemistry, 2000, Rajski, Scott R; Williams, Robert M
QSAR study of dual cyclooxygenase and 5-lipoxygenase inhibitors 2,6-di- tert-butylphenol derivatives
score: 0.92169833, Bioorganic & Medicinal Chemistry, 2003, Ruiz, Juan; Pérez, Carmen; Pouplana, Ramon
Synthesis and initial PET imaging of new potential dopamine D 3 receptor radioligands ( E)-4,3,2-[ 11C]methoxy- N-4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl-cinnamoylamides
score: 0.92166952, Bioorganic & Medicinal Chemistry, 2005, Gao, Mingzhang et. al.
Determinants of individual variation in intracellular accumulation of anti-HIV nucleoside analog metabolites.
score: 0.92166696, Antimicrobial agents and chemotherapy, 2011, Paintsil, Elijah et. al.
Enzymatic α(2–3)sialylation of non-natural type-I (Lewis c) disaccharides with recombinant sialyl-transferase
score: 0.9216549, Bioorganic & Medicinal Chemistry Letters, 1998, Baisch, Gabi; Öhrlein, Reinhold; Streiff, Markus
Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties
score: 0.9216072, Bioorganic & Medicinal Chemistry, 2006, Takano, Yasuo et. al.
Determinants of Intrinsic Aminoglycoside Resistance in Pseudomonas aeruginosa.
score: 0.92151421, Antimicrobial agents and chemotherapy, 2012, Krahn, Thomas et. al.
The disaccharide anthracycline MEN 10755 binds human serum albumin to a non-classical drug binding site
score: 0.9212802, Bioorganic & Medicinal Chemistry, 2002, Messori, Luigi et. al.
Using guanidinium groups for the recognition of RNA and as catalysts for the hydrolysis of RNA
score: 0.92116926, Bioorganic & Medicinal Chemistry, 1997, Perreault, Denise M.; Cabell, Larry A.; Anslyn, Eric V.
Hybridized and isosteric analogues of N 1-acetyl- N 4-dimethyl-piperazinium iodide (ADMP) and N 1-phenyl- N 4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action
score: 0.92098495, Bioorganic & Medicinal Chemistry, 1999, Manetti, Dina et. al.
Cloning and characterization of a gene, pbpF, encoding a new penicillin-binding protein, PBP2B, in Staphylococcus aureus.
score: 0.9207364, Antimicrobial agents and chemotherapy, 1999, Komatsuzawa, H et. al.
Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center.
score: 0.9206537, Antimicrobial agents and chemotherapy, 2006, Long, Katherine S et. al.
The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
score: 0.92059633, Nature chemical biology, 2006, Wille, Georg et. al.
Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy.
score: 0.92044583, Antimicrobial agents and chemotherapy, 2001, Villani, P et. al.
Molecular dynamics simulations of the amyloid-beta binding alcohol dehydrogenase (ABAD) enzyme
score: 0.92038124, Bioorganic & Medicinal Chemistry, 2008, Marques, Alexandra T. et. al.
Substituted glycals as probes of glycosidase mechanisms
score: 0.92036457, Bioorganic & Medicinal Chemistry, 1996, Lai, Ellen C.K. et. al.
Two novel vaginal microbicides (polystyrene sulfonate and cellulose sulfate) inhibit Gardnerella vaginalis and anaerobes commonly associated with bacterial vaginosis.
score: 0.9203404, Antimicrobial agents and chemotherapy, 2002, Simoes, Jose A et. al.
Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient.
score: 0.9201636, Antimicrobial agents and chemotherapy, 2005, Hantz, Sébastien et. al.
Consequences of interaction of a lipophilic endotoxin antagonist with plasma lipoproteins.
score: 0.92004877, Antimicrobial agents and chemotherapy, 2000, Rose, J R et. al.
Differential diffusions of indinavir and lopinavir in genital secretions of human immunodeficiency virus-infected women.
score: 0.91995878, Antimicrobial agents and chemotherapy, 2004, Launay, Odile et. al.
Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine.
score: 0.91983271, Antimicrobial agents and chemotherapy, 1999, Zhou, T et. al.
Primary amines protect against retinal degeneration in mouse models of retinopathies
score: 0.91978852, Nature chemical biology, 2011, Maeda, Akiko et. al.
UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability
score: 0.9197766, Bioorganic & Medicinal Chemistry, 2009, Langkjær, Niels; Pasternak, Anna; Wengel, Jesper
Suppression of gastric acid production by proton pump inhibitor treatment facilitates colonization of the large intestine by vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in clindamycin-treated mice.
score: 0.9195262, Antimicrobial agents and chemotherapy, 2006, Stiefel, Usha et. al.
Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes
score: 0.9195258, Bioorganic & Medicinal Chemistry, 2006, Girennavar, Basavaraj et. al.
Levofloxacin inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.
score: 0.91949365, Antimicrobial agents and chemotherapy, 2012, Yamaya, Mutsuo et. al.
A comparative density-functional study of the reaction mechanism of the O 2-dependent coproporphyrinogen III oxidase
score: 0.91930396, Bioorganic & Medicinal Chemistry, 2008, Silva, Pedro J.; Ramos, Maria João
Pharmacokinetics of telbivudine following oral administration of escalating single and multiple doses in patients with chronic hepatitis B virus infection: pharmacodynamic implications.
score: 0.91920861, Antimicrobial agents and chemotherapy, 2006, Zhou, Xiao-Jian et. al.
Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4]triazol-3-yl)methyl-5-oxo- [1,2,4]triazole derivatives
score: 0.91920538, European Journal of Medicinal Chemistry, 2004, Demirbas, Neslihan et. al.
Effects of synthetic cecropin analogs on in vitro growth of Acholeplasma laidlawii.
score: 0.91918146, Antimicrobial agents and chemotherapy, 2001, Borth, W B; Jones, V P; Ullman, D E; Hu, J S
Sequence diversity of the reverse transcriptase of human immunodeficiency virus type 1 from untreated Brazilian individuals.
score: 0.91897167, Antimicrobial agents and chemotherapy, 1999, Brindeiro, R et. al.
Synthesis of some analogues of blattellastanoside A, the steroidal aggregation pheromone of the German cockroach
score: 0.918907, Bioorganic & Medicinal Chemistry, 1996, Mori, Kenji; Nakayama, Tôru; Sakuma, Masayuki
Synthesis and biological activity of new derivatives of 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid
score: 0.91889713, European Journal of Medicinal Chemistry, 2004, Modzelewska-Banachiewicz, Boźena et. al.
Polymer supported synthesis of aminooxyalkylated oligonucleotides, and some applications in the fabrication of microarrays
score: 0.91880359, Bioorganic & Medicinal Chemistry, 2009, Sethi, D. et. al.
Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing
score: 0.91871896, Bioorganic & Medicinal Chemistry, 2013, Lama, Rati et. al.
Modulation of remote DNA oxidation by hybridization with peptide nucleic acids (PNA)
score: 0.91871118, Bioorganic & Medicinal Chemistry, 2002, Okamoto, Akimitsu et. al.
Synthesis of d- and l-apio nucleoside analogues with 2′-hydroxyl group as potential anti-HIV agents
score: 0.91863139, Bioorganic & Medicinal Chemistry, 2004, Jin, Dong Zhe et. al.
In vitro resistance profile of the candidate HIV-1 microbicide drug dapivirine.
score: 0.91857929, Antimicrobial agents and chemotherapy, 2012, Schader, Susan M et. al.
New diketone based vanadium complexes as insulin mimetics
score: 0.91857348, European Journal of Medicinal Chemistry, 2008, Sheela, A.; Roopan, S. Mohana; Vijayaraghavan, R.
Bis-pyrene labeled DNA aptamer as an intelligent fluorescent biosensor
score: 0.91853005, Bioorganic & Medicinal Chemistry Letters, 2003, Yamana, Kazushige et. al.
Concise syntheses of arabinogalactans with β-(1→6)-linked galactopyranose backbones and α-(1→3)- and α-(1→2)-linked arabinofuranose side chains
score: 0.91843497, Bioorganic & Medicinal Chemistry, 2005, Li, Aixiao; Kong, Fanzuo
Ertapenem pharmacokinetics and impact on intestinal microflora, in comparison to those of ceftriaxone, after multiple dosing in male and female volunteers.
score: 0.91822064, Antimicrobial agents and chemotherapy, 2004, Pletz, Mathias W R et. al.
A thiolate ligand on a cytochrome P-450 mimic permits the use of simple environmentally benign oxidants for biomimetic steroid hydroxylation in water
score: 0.9181654, Bioorganic & Medicinal Chemistry Letters, 2005, Fang, Zhenglai; Breslow, Ronald
Interaction of wogonin with bovine serum albumin
score: 0.91808902, Bioorganic & Medicinal Chemistry, 2005, Tian, Jianniao; Liu, Jiaqin; Hu, Zhide; Chen, Xingguo
Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae.
score: 0.91795743, Antimicrobial agents and chemotherapy, 2002, Emerson, Lyndal R et. al.
Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.
score: 0.9178878, Antimicrobial agents and chemotherapy, 2006, Chiang, Lisa Y et. al.
In vitro comparison of nitrofurazone- and silver alloy-coated foley catheters for contact-dependent and diffusible inhibition of urinary tract infection-associated microorganisms.
score: 0.91787031, Antimicrobial agents and chemotherapy, 2012, Johnson, James R; Johnston, Brian; Kuskowski, Michael A
A small-molecule screen identifies new functions for the plant hormone strigolactone.
score: 0.91777133, Nature chemical biology, 2010, Tsuchiya, Yuichiro et. al.
Toward the antibody-catalyzed chemiluminescence. Design and synthesis of hapten
score: 0.91757491, Bioorganic & Medicinal Chemistry Letters, 1998, Sawa, Masaaki et. al.
Pseudomonas aeruginosa exopolysaccharide Psl promotes resistance to the biofilm inhibitor polysorbate 80.
score: 0.91740162, Antimicrobial agents and chemotherapy, 2012, Zegans, Michael E et. al.
Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol.
score: 0.91726517, Antimicrobial agents and chemotherapy, 2000, Bammert, G F; Fostel, J M
Monitoring of duplex and triplex formation by 19F NMR using oligodeoxynucleotides possessing 5-fluorodeoxyuridine unit as 19F signal transmitter
score: 0.91724686, Bioorganic & Medicinal Chemistry, 2010, Tanabe, Kazuhito; Sugiura, Masaaki; Nishimoto, Sei-ichi
Liver-targeted siRNA delivery by polyethylenimine (PEI)-pullulan carrier
score: 0.91719864, Bioorganic & Medicinal Chemistry, 2010, Kang, Jeong-Hun et. al.
Efficacy of macrolides and telithromycin against leptospirosis in a hamster model.
score: 0.91718569, Antimicrobial agents and chemotherapy, 2006, Moon, James E et. al.
Deoxyiminoalditols from aldonolactones — V. Preparation of the four stereoisomers of 1,5-dideoxy-1,5-iminopentitols. Evaluation of these iminopentitols and three 1,5-dideoxy-1,5-iminoheptitols as glycosidase inhibitors
score: 0.91713538, Bioorganic & Medicinal Chemistry, 1996, Godskesen, Michael et. al.
Effect of various antibacterial preparations on the pathogenic oral flora in elderly patients fed via nasogastric tube.
score: 0.91693705, Antimicrobial agents and chemotherapy, 2005, Leibovitz, Arthur; Carmeli, Yehuda; Segal, Refael
Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry
score: 0.91659721, Bioorganic & Medicinal Chemistry, 2009, Feng, Xidong et. al.
Comparative in vitro efficacies and antimicrobial durabilities of novel antimicrobial central venous catheters.
score: 0.91656166, Antimicrobial agents and chemotherapy, 2006, Hanna, Hend et. al.
Plant extracts with anti-inflammatory properties—A new approach for characterization of their bioactive compounds and establishment of structure–antioxidant activity relationships
score: 0.91647019, Bioorganic & Medicinal Chemistry, 2009, Amaral, Sónia et. al.
Multiple reactive immunization towards the hydrolysis of organophosphorus nerve agents: hapten design and synthesis
score: 0.91626487, Bioorganic & Medicinal Chemistry, 2001, Huang, Haihong et. al.
Peptide synthesis in organic media with subtilisin 72 immobilized on poly(vinyl alcohol)-cryogel carrier
score: 0.91622656, Bioorganic & Medicinal Chemistry Letters, 2001, Bacheva, Anna V et. al.
Anion-selective transport activities of tetrameric sterol–spermine conjugates
score: 0.91617828, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Wen-Hua; Zhou, Jia; Wang, Yong-Min
Anion-selective transport activities of tetrameric sterol–spermine conjugates
score: 0.91617828, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Wen-Hua; Zhou, Jia; Wang, Yong-Min
Anion-selective Transport Activities of Tetrameric Sterol-Spermine Conjugates
score: 0.91617828, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Wen-Hua; Zhou, Jia; Wang, Yong-Min
Anion-selective transport activities of tetrameric sterol–spermine conjugates
score: 0.91617828, Bioorganic & Medicinal Chemistry Letters, 2012, Chen, Wen-Hua; Zhou, Jia; Wang, Yong-Min
A New Class of RAR Subtype Selective Retinoids: Correlation of Pharmacological Effects with Receptor Activity
score: 0.9159363, Bioorganic & Medicinal Chemistry, 1999, Vuligonda, Vidyasagar et. al.
Flavonols from Heterotheca inuloides: Tyrosinase Inhibitory Activity and Structural Criteria
score: 0.9159355, Bioorganic & Medicinal Chemistry, 2000, Kubo, Isao et. al.
CesRK, a two-component signal transduction system in Listeria monocytogenes, responds to the presence of cell wall-acting antibiotics and affects beta-lactam resistance.
score: 0.91593052, Antimicrobial agents and chemotherapy, 2003, Kallipolitis, Birgitte H et. al.
Targeting a ruthenium complex to the nucleus with short peptides
score: 0.91584715, Bioorganic & Medicinal Chemistry, 2010, Puckett, Cindy A.; Barton, Jacqueline K.
Differential in vivo activities of anidulafungin, caspofungin, and micafungin against Candida glabrata isolates with and without FKS resistance mutations.
score: 0.91583332, Antimicrobial agents and chemotherapy, 2012, Arendrup, Maiken Cavling et. al.
Libraries of opiate and anti-opiate peptidomimetics containing 2,3-methanoleucine
score: 0.91577973, Bioorganic & Medicinal Chemistry, 1997, Burgess, Kevin et. al.
Influence of conformationally restricted pyrimidines on the activity of 10–23 DNAzymes
score: 0.91573864, Bioorganic & Medicinal Chemistry, 2012, Robaldo, Laura et. al.
Ruthenium (II) nitrofurylsemicarbazone complexes: new DNA binding agents
score: 0.91559554, European Journal of Medicinal Chemistry, 2004, Cabrera, Eliana et. al.
Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations.
score: 0.91552936, Antimicrobial agents and chemotherapy, 1998, Johnson, E M et. al.
Synthesis of 2′-C-α-difluoromethylarauridine and its 3′-O-phosphoramidite incorporation into a hammerhead ribozyme
score: 0.91547053, Bioorganic & Medicinal Chemistry Letters, 1999, Dunkel, Martin; Reither, Vivian
Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug
score: 0.91541878, European Journal of Medicinal Chemistry, 2007, Ma, Minglu et. al.
Coulombic effects on the traceless Staudinger ligation in water
score: 0.91533164, Bioorganic & Medicinal Chemistry, 2009, Tam, Annie; Raines, Ronald T.
Ritonavir
score: 0.91531207, Bioorganic & Medicinal Chemistry, 1997,
Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis.
score: 0.91528706, Antimicrobial agents and chemotherapy, 2006, Kirkpatrick, William R; Coco, Brent J; Patterson, Thomas F
Site-directed mutagenesis of monofunctional chorismate mutase engineered from the E. coli P-protein
score: 0.9152721, Bioorganic & Medicinal Chemistry, 1996, Zhang, Sheng et. al.
In vitro selection of phosphorothiolated aptamers
score: 0.91524208, Bioorganic & Medicinal Chemistry Letters, 1998, Jhaveri, Sulay; Olwin, Brad; Ellington, Andrew D.
AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters.
score: 0.91515486, Antimicrobial agents and chemotherapy, 2005, Su, Xian-Zhong et. al.
β-1,4-Galactosyltransferase-catalyzed Synthesis of the Branched Tetrasaccharide Repeating Unit of Streptococcus pneumoniae Type 14
score: 0.91498504, Bioorganic & Medicinal Chemistry, 1998, Niggemann, Jutta et. al.
Mitochondrial ribosome as the target for the macrolide antibiotic clarithromycin in the helminth Echinococcus multilocularis.
score: 0.91492358, Antimicrobial agents and chemotherapy, 2005, Mathis, Alexander et. al.
Systematic review and meta-analysis of the tolerability and hepatotoxicity of antifungals in empirical and definitive therapy for invasive fungal infection.
score: 0.91473807, Antimicrobial agents and chemotherapy, 2010, Wang, Jiun-Ling et. al.
Pharmacokinetics of rifapentine in subjects seropositive for the human immunodeficiency virus: a phase I study.
score: 0.91468621, Antimicrobial agents and chemotherapy, 1999, Keung, A C et. al.
Effect of Transcriptional Activators SoxS, RobA, and RamA on Expression of Multidrug Efflux Pump AcrAB-TolC in Enterobacter cloacae.
score: 0.91464337, Antimicrobial agents and chemotherapy, 2012, Pérez, Astrid et. al.
Aminoglycosides: nephrotoxicity.
score: 0.91458473, Antimicrobial agents and chemotherapy, 1999, Mingeot-Leclercq, M P; Tulkens, P M
Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.
score: 0.91427895, Antimicrobial agents and chemotherapy, 2006, Niimi, K et. al.
Pharmacokinetics of darunavir at 900 milligrams and ritonavir at 100 milligrams once daily when coadministered with efavirenz at 600 milligrams once daily in healthy volunteers.
score: 0.91417833, Antimicrobial agents and chemotherapy, 2010, Soon, Gaik H et. al.
Structural characterization and antimicrobial activity of 1,3-bis(2-benzimidazyl)-2-thiapropane ligand and its Pd(II) and Zn(II) halide complexes
score: 0.91410968, European Journal of Medicinal Chemistry, 2005, Agh-Atabay, Naz M.; Dulger, Basaran; Gucin, Fahrettin
A Practical Synthesis and Biological Evaluation of 9-Halogenated PGF Analogues
score: 0.91400119, Bioorganic & Medicinal Chemistry, 2002, Tani, Kousuke et. al.
Catabolism of the hemoregulatory peptide N-Acetyl-Ser-Asp-Lys-Pro: a new insight into the physiological role of the angiotensin-I-converting enzyme N-active site
score: 0.91392595, Bioorganic & Medicinal Chemistry, 1996, Rousseau-Plasse, Anne; Lenfant, Maryse; Potier, Pierre
Conformational probes for elucidating the nature of substance P binding to the NK 1 receptor: initial efforts to map the Phe 7-Phe 8 region
score: 0.91391817, Bioorganic & Medicinal Chemistry Letters, 1998, Tong, Yunsong et. al.
The use of neamine as a molecular template: Identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3′-phosphotransferase type IIa by mass spectroscopy
score: 0.91383868, Bioorganic & Medicinal Chemistry Letters, 1998, Yang, Yi et. al.
Antibody-catalyzed oxidative degradation of nicotine using riboflavin
score: 0.91382568, Bioorganic & Medicinal Chemistry, 2004, Dickerson, Tobin J.; Yamamoto, Noboru; Janda, Kim D.
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
score: 0.91381277, Nature chemical biology, 2011, Park, Je Won et. al.
Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent
score: 0.91380027, Bioorganic & Medicinal Chemistry Letters, 2012, Pandey, Suresh K. et. al.
Synthesis and in vitro characterization of trans- and cis-[18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor
score: 0.91361303, European Journal of Medicinal Chemistry, 2012, Koudih, Radouane et. al.
Synthesis and in vitro characterization of trans- and cis-[18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor
score: 0.91361303, European Journal of Medicinal Chemistry, 2012, Koudih, Radouane et. al.
Shiga-like toxin II impairs hepatobiliary transport of doxorubicin in rats by down-regulation of hepatic P glycoprotein and multidrug resistance-associated protein Mrp2.
score: 0.91346833, Antimicrobial agents and chemotherapy, 2003, Hidemura, Kazuhiko et. al.
New chlorogenin hexasaccharide isolated from Agave fourcroydes with cytotoxic and cell cycle inhibitory activities
score: 0.91345987, Bioorganic & Medicinal Chemistry, 2004, Ohtsuki, Takashi et. al.
Linear and nonlinear QSAR study of N-hydroxy-2-[(phenylsulfonyl)amino]acetamide derivatives as matrix metalloproteinase inhibitors
score: 0.9133401, Bioorganic & Medicinal Chemistry, 2006, Fernández, Michael; Caballero, Julio; Tundidor-Camba, Alain
Drug-drug interaction study of ketoconazole and ritonavir-boosted saquinavir.
score: 0.91332581, Antimicrobial agents and chemotherapy, 2009, Kaeser, Benoite et. al.
Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor
score: 0.91318067, Bioorganic & Medicinal Chemistry Letters, 2012, Hao, Jia et. al.
Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor
score: 0.91318067, Bioorganic & Medicinal Chemistry Letters, 2012, Hao, Jia et. al.
Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor
score: 0.91318067, Bioorganic & Medicinal Chemistry Letters, 2012, Hao, Jia et. al.
Oligonucleotides containing 2′- O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2′-aldehyde oligonucleotides for chemoselective ligation
score: 0.91296984, Bioorganic & Medicinal Chemistry, 2005, Zubin, Eugeny M. et. al.
Ligand binding to I 2 imidazoline receptor: The role of lipophilicity in quantitative structure—activity relationship models
score: 0.91286536, Bioorganic & Medicinal Chemistry, 1998, Pigini, M. et. al.
A straightforward stereoselective synthesis of meso-, ( S, S)- and ( R, R)-2,6-diaminopimelic acids from cis-1,4-diacetoxycyclohept-2-ene
score: 0.91278509, Bioorganic & Medicinal Chemistry Letters, 2007, Saito, Yukako et. al.
DFT study of the reductive decomposition of artemisinin
score: 0.91272887, Bioorganic & Medicinal Chemistry, 2006, Taranto, Alex Gutterres et. al.
Scabrosin esters and derivatives: chemical derivatization studies and biological evaluation
score: 0.91263911, Bioorganic & Medicinal Chemistry, 2004, Chai, Christina L.L. et. al.
Total synthesis of 25-Hydroxy-16,23 E-diene Vitamin D 3 and 1α,25-Dihydroxy-16,23 E-diene Vitamin D 3: separation of genomic and nongenomic vitamin D Activities
score: 0.91261835, Bioorganic & Medicinal Chemistry, 1998, Kabat, Marek M. et. al.
Evaluation of aldose reductase inhibition and docking studies of some secondary metabolites, isolated from Origanum vulgare L. ssp. hirtum
score: 0.91225871, Bioorganic & Medicinal Chemistry, 2006, Koukoulitsa, Catherine et. al.
Syntheses and preventive effects of analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D 3 (ED-71) on bone mineral loss in ovariectomized rats
score: 0.91205004, Bioorganic & Medicinal Chemistry, 1998, Ono, Yoshiyuki et. al.
Lack of effect of experimental hypovolemia on imipenem muscle distribution in rats assessed by microdialysis.
score: 0.91203109, Antimicrobial agents and chemotherapy, 2005, Marchand, Sandrine et. al.
Synthesis and antimicrobial properties of imidazolium and pyrrolidinonium salts
score: 0.91189041, Bioorganic & Medicinal Chemistry, 2004, Demberelnyamba, D. et. al.
Synthesis and in vitro evaluation of S-acyl-3-thiopropyl prodrugs of Foscarnet
score: 0.91184392, Bioorganic & Medicinal Chemistry, 2004, Gagnard, Valérie et. al.
Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood.
score: 0.91181942, Antimicrobial agents and chemotherapy, 1998, Schultz, M J et. al.
Enantiomers of cis- and trans-3-(4-propyl-cyclopent-2-enyl) propyl acetate. A study on the bioactive conformation and chiral recognition of a moth sex pheromone component
score: 0.91176153, Bioorganic & Medicinal Chemistry, 1997, Gustavsson, Anna-Lena et. al.
Inhibitory effects of l-arginine derivatives on endothelium-dependent vasorelaxing response to acetylcholine of the rat aorta
score: 0.91170904, European Journal of Medicinal Chemistry, 2004, Wang, Guei-Jane; Lai, Tzi-Chung; Chen, Chinpiao
Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae.
score: 0.91168779, Antimicrobial agents and chemotherapy, 1998, Suzuki, N; Lee, C K; Nihira, T; Yamada, Y
1,8-Naphthyridines IV. 9-Substituted N, N-dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3- a][1,8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities
score: 0.91159059, European Journal of Medicinal Chemistry, 2000, Roma, Giorgio et. al.
Coordination of iron ions in the form of histidinyl dinitrosyl complexes does not prevent their genotoxicity
score: 0.91157261, Bioorganic & Medicinal Chemistry, 2012, Lewandowska, Hanna et. al.
Coordination of iron ions in the form of histidinyl dinitrosyl complexes does not prevent their genotoxicity
score: 0.91157261, Bioorganic & Medicinal Chemistry, 2012, Lewandowska, Hanna et. al.
Coordination of iron ions in the form of histidinyl dinitrosyl complexes does not prevent their genotoxicity
score: 0.91157261, Bioorganic & Medicinal Chemistry, 2012, Lewandowska, Hanna et. al.
Anticonvulsant evaluation and mechanism of action of benzylamino enaminones
score: 0.91145699, Bioorganic & Medicinal Chemistry, 2006, Edafiogho, Ivan O. et. al.
Multicenter evaluation of a new DNA microarray for rapid detection of clinically relevant bla genes from beta-lactam-resistant gram-negative bacteria.
score: 0.91141625, Antimicrobial agents and chemotherapy, 2011, Bogaerts, Pierre et. al.
Synthesis and photodynamic activity of zinc(II) phthalocyanine derivatives bearing methoxy and trifluoromethylbenzyloxy substituents in homogeneous and biological media
score: 0.91131569, Bioorganic & Medicinal Chemistry, 2005, Yslas, E. Inés; Rivarola, Viviana; Durantini, Edgardo N.
Protective efficacy of a sulfated sialyl lipid (NMSO3) against human rotavirus-induced diarrhea in a mouse model.
score: 0.91123279, Antimicrobial agents and chemotherapy, 2002, Takahashi, Kazuo et. al.
Binary and ternary inclusion complexes of finasteride in HPβCD and polymers: Preparation and characterization
score: 0.91120548, Bioorganic & Medicinal Chemistry, 2009, Asbahr, Ana Carolina C. et. al.
LfrR is a repressor that regulates expression of the efflux pump LfrA in Mycobacterium smegmatis.
score: 0.91119746, Antimicrobial agents and chemotherapy, 2006, Buroni, Silvia et. al.
Ionization behaviour and tautomerism-dependent lipophilicity of pyridine-2(1 H)-one cardiotonic agents
score: 0.91101105, Bioorganic & Medicinal Chemistry, 2000, Altomare, C. et. al.
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents
score: 0.91090888, Bioorganic & Medicinal Chemistry, 2013, Wang, Hai-Hong et. al.
T7 RNA polymerase activation and improvement of the transcriptional sequencing by polyamines
score: 0.91086312, Bioorganic & Medicinal Chemistry, 2000, Iwata, Masaaki et. al.
International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations.
score: 0.91083601, Antimicrobial agents and chemotherapy, 2009, Brüggemann, Roger J M et. al.
Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure–activity relationship study
score: 0.91071011, Bioorganic & Medicinal Chemistry, 2001, Komoda, Masato et. al.
Chlorine atom substitution influences radical scavenging activity of 6-chromanol
score: 0.91068131, Bioorganic & Medicinal Chemistry, 2012, Inami, Keiko et. al.
Abacavir sulfate
score: 0.91057774, Bioorganic & Medicinal Chemistry, 1999, Huff, Joel R
A new heterobifunctional reagent for immobilization of biomolecules on glass surface
score: 0.91052562, Bioorganic & Medicinal Chemistry Letters, 2004, Kumar, P.; Agrawal, S.K.; Misra, A.; Gupta, K.C.
Role of ABC transporters in aureobasidin A resistance.
score: 0.91048944, Antimicrobial agents and chemotherapy, 1998, Ogawa, A et. al.
Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.
score: 0.91048239, Antimicrobial agents and chemotherapy, 2011, Schubert, Sabrina et. al.
Chemo-enzymatic synthesis of a new type of enantiomerically pure carbocyclic nucleoside analogues with strong inhibitory effects on terminal deoxynucleotidyl transferase
score: 0.91031913, Bioorganic & Medicinal Chemistry, 1998, Theil, Fritz et. al.
Uptake of nitrobenzylthioinosine and purine beta-L-nucleosides by intracellular Toxoplasma gondii.
score: 0.91024083, Antimicrobial agents and chemotherapy, 2003, Al Safarjalani, Omar N et. al.
Targeting of polyamidoamine–DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation
score: 0.91022837, Bioorganic & Medicinal Chemistry, 2008, Parkhouse, Susan M.; Garnett, Martin C.; Chan, Weng C.
Extent of cross-resistance between agents used to treat human immunodeficiency virus type 1 infection in clinically derived isolates.
score: 0.9101033, Antimicrobial agents and chemotherapy, 2002, Harrigan, P Richard; Larder, Brendan A
Structure—activity studies leading to potent chloride channel blockers: 5 e-tert-butyl-2-[4-(substituted-ethynyl)phenyl]-1,3-dithianes
score: 0.91007244, Bioorganic & Medicinal Chemistry, 1994, Li, Qing X.; Casida, John E.
Cu(II) cyclen cleavage agent for human islet amyloid peptide
score: 0.91005202, Bioorganic & Medicinal Chemistry, 2010, Jeong, Keunhong et. al.
The effect of C(5) cytosine methylation at CpG sequences on mitomycin–DNA bonding profiles
score: 0.910052, Bioorganic & Medicinal Chemistry, 2001, Li, Ven-Shun; Tang, Moon-shong; Kohn, Harold
Uptake and intracellular transport of RNA Aptamers in African trypanosomes suggest therapeutic “Piggy-Back” approach
score: 0.91004398, Bioorganic & Medicinal Chemistry, 2001, Homann, Matthias; Ulrich Göringer, H
Synthesis and studies of 3′- C-trifluoromethyl nucleoside analogues bearing adenine or cytosine as the base
score: 0.90997149, Bioorganic & Medicinal Chemistry, 2002, Jeannot, Frédéric et. al.
Different Genetic Supports for the tet(S) Gene in Enterococci.
score: 0.90986286, Antimicrobial agents and chemotherapy, 2012, Novais, Carla et. al.
Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds
score: 0.90945112, Bioorganic & Medicinal Chemistry, 2005, Okouchi, Tomoharu et. al.
Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: Further evidence for the existence of an abnormal pathway for heme biosynthesis
score: 0.90944225, Bioorganic & Medicinal Chemistry, 2005, Cooper, Christopher L. et. al.
Synthesis of antioxidant propyl gallate using tannase from Aspergillus niger van Teighem in nonaqueous media
score: 0.90929412, Bioorganic & Medicinal Chemistry Letters, 2003, Sharma, Shweta; Gupta, Munishwar N
Plant agricultural streptomycin formulations do not carry antibiotic resistance genes.
score: 0.90927977, Antimicrobial agents and chemotherapy, 2009, Rezzonico, Fabio; Stockwell, Virginia O; Duffy, Brion
New cerium(III) complexes of coumarins – Synthesis, characterization and cytotoxicity evaluation
score: 0.90927852, European Journal of Medicinal Chemistry, 2008, Kostova, Irena; Momekov, Georgi
Fluorescence-based detection of short DNA sequences under non-denaturing conditions
score: 0.90916573, Bioorganic & Medicinal Chemistry, 2008, Smolina, Irina V. et. al.
The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)2 , d(CGATCG)2 and d(CGCGCG)2 shows a strong but reversible binding to G : C base pairs
score: 0.9090957, Bioorganic & Medicinal Chemistry, 2012, Mazzini, Stefania et. al.
Directed evolution: overcoming biology's limitations.
score: 0.90901026, Nature chemical biology, 2010, Appella, Daniel H
Salmonella genomic island 1 (SGI1), variant SGI1-I, and new variant SGI1-O in proteus mirabilis clinical and food isolates from China.
score: 0.90900656, Antimicrobial agents and chemotherapy, 2008, Boyd, David A et. al.
Aminoglycoside binding to human and bacterial A-Site rRNA decoding region constructs
score: 0.90887102, Bioorganic & Medicinal Chemistry, 2001, Hyun Ryu, Do; Rando, Robert R
A new scaffold for amide ligation
score: 0.90884509, Bioorganic & Medicinal Chemistry, 2001, Marinzi, Chiara et. al.
Efficacy of bacteriophage therapy against gut-derived sepsis caused by Pseudomonas aeruginosa in mice.
score: 0.90876599, Antimicrobial agents and chemotherapy, 2007, Watanabe, Ryohei et. al.
Moraxella catarrhalis outer membrane vesicles carry β-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin.
score: 0.9086995, Antimicrobial agents and chemotherapy, 2011, Schaar, Viveka et. al.
Acetoxy drug: Protein transacetylase catalyzed activation of human platelet nitric oxide synthase by polyphenolic peracetates
score: 0.90869603, Bioorganic & Medicinal Chemistry, 2006, Khurana, Pulkit et. al.
Short-course gentamicin in combination with daptomycin or vancomycin against Staphylococcus aureus in an in vitro pharmacodynamic model with simulated endocardial vegetations.
score: 0.90852009, Antimicrobial agents and chemotherapy, 2005, Tsuji, Brian T; Rybak, Michael J
Enhancing effect of indirubin derivatives on 1,25-dihydroxyvitamin D 3- and all- trans retinoic acid-induced differentiation of HL-60 leukemia cells
score: 0.90849174, Bioorganic & Medicinal Chemistry, 2006, Kim, Seung Hyun et. al.
Synthesis and evaluation of C-9 modified N-acetylneuraminic acid derivatives as substrates for N-acetylneuraminic acid aldolase
score: 0.90845899, Bioorganic & Medicinal Chemistry, 2000, Kiefel, Milton J. et. al.
Compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations.
score: 0.90842527, Antimicrobial agents and chemotherapy, 2006, Groll, Andreas H et. al.
Fluorescence spectroscopic investigation of the interaction between chloramphenicol and lysozyme
score: 0.90839892, European Journal of Medicinal Chemistry, 2009, Ding, Fei; Zhao, Guangyu; Huang, Jinli; Sun, Ying; Zhang, Li
Involvement of enterobactin synthesis pathway in production of microcin H47.
score: 0.90836143, Antimicrobial agents and chemotherapy, 2004, Azpiroz, María F; Laviña, Magela
Mechanisms of azole resistance in petite mutants of Candida glabrata.
score: 0.90835263, Antimicrobial agents and chemotherapy, 2004, Brun, Sophie et. al.
Variation in the composition and pore function of major outer membrane pore protein P2 of Haemophilus influenzae from cystic fibrosis patients.
score: 0.90817023, Antimicrobial agents and chemotherapy, 1999, Regelink, A G et. al.
Pharmacokinetic study of an oral cephalosporin, cefdinir, in hemodialysis patients.
score: 0.90816689, Antimicrobial agents and chemotherapy, 1998, Hishida, A et. al.
Herpes simplex virus ribonucleotide reductase subunit association inhibitors: the effect and conformation of β-alkylated aspartic acid derivatives
score: 0.90809653, Bioorganic & Medicinal Chemistry, 1994, Moss, Neil et. al.
Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis
score: 0.90800131, European Journal of Medicinal Chemistry, 2003, Hartmann, Rolf W.; Müller, Ursula; Ehmer, Peter B.
Structure–activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists
score: 0.90796372, Bioorganic & Medicinal Chemistry, 2006, Drizin, Irene et. al.
Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines
score: 0.9079015, Bioorganic & Medicinal Chemistry, 2005, Vintém, Ana Paula B. et. al.
High-frequency transposition for determining antibacterial mode of action.
score: 0.90762999, Nature chemical biology, 2011, Wang, Hao et. al.
Benzo[ b]acronycine derivatives: a novel class of antitumor agents
score: 0.90744368, European Journal of Medicinal Chemistry, 2004, Michel, Sylvie; Gaslonde, Thomas; Tillequin, François
Synthesis, characterization, antifungal and anti-HIV activities of metal(II) complexes of 4,6-di- tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol
score: 0.9073654, European Journal of Medicinal Chemistry, 2008, Loginova, Natalia V. et. al.
Cleavage of L-leucine-containing dipeptides by Clostridium butyricum
score: 0.90725299, Bioorganic & Medicinal Chemistry Letters, 1999, Khelifa, Nasser et. al.
New Description of Protein-Ligand Interactions Using a Spherical Self-Organizing Map
score: 0.90723104, Bioorganic & Medicinal Chemistry, 2012, Hasegawa, Kiyoshi; Funatsu, Kimito
Modeling in vivo pharmacokinetics and pharmacodynamics of moxifloxacin therapy for Mycobacterium tuberculosis infection by using a novel cartridge system.
score: 0.90720812, Antimicrobial agents and chemotherapy, 2005, Ginsburg, Amy Sarah et. al.
Sensitive and selective viral DNA detection assay via microbead-based rolling circle amplification
score: 0.90717315, Bioorganic & Medicinal Chemistry Letters, 2008, Schopf, Eric et. al.
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
score: 0.907082, Antimicrobial agents and chemotherapy, 2000, Cruz, M C et. al.
Biocidal activity of some Mannich base cationic derivatives
score: 0.90703256, Bioorganic & Medicinal Chemistry, 2005, Negm, Nabel A.; Morsy, Salwa M.I.; Said, Medhat M.
Activities of sordarins in murine histoplasmosis.
score: 0.90688651, Antimicrobial agents and chemotherapy, 1999, Graybill, J R et. al.
Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo ( b) thieno[2,3- d]pyrimidin-4(3 H)-ones
score: 0.90685044, European Journal of Medicinal Chemistry, 2006, Alagarsamy, V. et. al.
Effects of antibiotics on nosocomial epidemiology of vancomycin-resistant enterococci.
score: 0.9067983, Antimicrobial agents and chemotherapy, 2002, Harbarth, Stephan; Cosgrove, Sara; Carmeli, Yehuda
Genetic methods for assessing antimicrobial resistance.
score: 0.90676385, Antimicrobial agents and chemotherapy, 1999, Cockerill, F R
Synthesis and evaluation of a radioiodinated bladder cancer specific peptide
score: 0.90674397, Bioorganic & Medicinal Chemistry, 2012, Ha, Yeong Su et. al.
SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation of erg11A (cyp51A).
score: 0.90670175, Antimicrobial agents and chemotherapy, 2012, Blosser, Sara J; Cramer, Robert A
Hydrogen bonding isosteres: bimolecular carboxylic acid and amine- N-oxide interactions mediated via CH···O hydrogen bonds
score: 0.90660177, Bioorganic & Medicinal Chemistry, 2000, Baures, P.W; Wiznycia, A; Beatty, A.M
Verification of the turn at positions 22 and 23 of the β-amyloid fibrils with Italian mutation using solid-state NMR
score: 0.90627051, Bioorganic & Medicinal Chemistry, 2005, Masuda, Yuichi et. al.
Activities of new macrolides and fluoroquinolones against Mycobacterium ulcerans infection in mice.
score: 0.90602177, Antimicrobial agents and chemotherapy, 2001, Bentoucha, A et. al.
Definition of an electronic profile of compounds with inhibitory activity against hematin aggregation in malaria parasite
score: 0.90592206, Bioorganic & Medicinal Chemistry, 2004, Portela, César et. al.
Population pharmacokinetics of artemether, lumefantrine, and their respective metabolites in Papua New Guinean children with uncomplicated malaria.
score: 0.90579982, Antimicrobial agents and chemotherapy, 2011, Salman, Sam et. al.
Antioxidant properties of 3-hydroxycoumarin derivatives
score: 0.90573531, Bioorganic & Medicinal Chemistry, 2004, Bailly, Fabrice et. al.
Effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum.
score: 0.90571975, Antimicrobial agents and chemotherapy, 1999, Niki, Y et. al.
Synthesis and biological evaluation of aroylguanidines related to amiloride as inhibitors of the human platelet Na +/H + exchanger
score: 0.90565079, Bioorganic & Medicinal Chemistry, 2002, Laeckmann, Didier et. al.
CC-1065/duocarmycin and bleomycin A 2 hybrid agents: Lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits
score: 0.90549039, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L; Han, Nianhe
Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin
score: 0.90546029, European Journal of Medicinal Chemistry, 2003, Chiroli, Valerio et. al.
The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity.
score: 0.90541973, Antimicrobial agents and chemotherapy, 2000, Lamb, D C; Kelly, D E; White, T C; Kelly, S L
Development of a new ultraporous polymer as support in organic synthesis
score: 0.90541852, Bioorganic & Medicinal Chemistry Letters, 2002, Deleuze, Hervé; Maillard, Bernard; Mondain-Monval, Olivier
A mass spectrometric investigation of the reaction between 4,4′-vinylenedipyridine bis[2,2′ : 6′,2″-terpyridine platinum (II)] and the self-complementary oligonucleotide d(CpGpTpApCpG)
score: 0.90523312, Bioorganic & Medicinal Chemistry, 1996, Lowe, Gordon et. al.
If taken 1 hour before indinavir (IDV), didanosine does not affect IDV exposure, despite persistent buffering effects.
score: 0.9052175, Antimicrobial agents and chemotherapy, 2001, Shelton, M J; Mei, H; Hewitt, R G; Defrancesco, R
The art of the chemical probe.
score: 0.90508518, Nature chemical biology, 2010, Frye, Stephen V
A comparison of DNA and RNA quadruplex structures and stabilities
score: 0.90505561, Bioorganic & Medicinal Chemistry, 2009, Joachimi, Astrid; Benz, Armin; Hartig, Jörg S.
In vitro activities of linezolid, meropenem, and quinupristin-dalfopristin against group C and G streptococci, including vancomycin-tolerant isolates.
score: 0.90499087, Antimicrobial agents and chemotherapy, 2001, Zaoutis, T; Moore, L S; Furness, K; Klein, J D
Ertapenem versus ceftriaxone followed by appropriate oral therapy for treatment of complicated urinary tract infections in adults: results of a prospective, randomized, double-blind multicenter study.
score: 0.90498658, Antimicrobial agents and chemotherapy, 2002, Tomera, Kevin M et. al.
Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitizers in photodynamic therapy
score: 0.9048581, Bioorganic & Medicinal Chemistry, 2003, Berger, Yann et. al.
Kinetic resolution of (±)-1-phenylethanol in [Bmim][PF 6] using high activity preparations of lipases
score: 0.9047646, Bioorganic & Medicinal Chemistry Letters, 2007, Shah, Shweta; Gupta, Munishwar N.
Human macrophage inflammatory protein 3alpha: protein and peptide nuclear magnetic resonance solution structures, dimerization, dynamics, and anti-infective properties.
score: 0.90468391, Antimicrobial agents and chemotherapy, 2008, Chan, David I et. al.
Ribosomes from an oxazolidinone-resistant mutant confer resistance to eperezolid in a Staphylococcus aureus cell-free transcription-translation assay.
score: 0.90453759, Antimicrobial agents and chemotherapy, 1998, Murray, R W; Schaadt, R D; Zurenko, G E; Marotti, K R
Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by schiff base-mediated crosslinking
score: 0.90448397, Bioorganic & Medicinal Chemistry Letters, 2003, Sugiyama, Toru et. al.
Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist
score: 0.90447777, European Journal of Medicinal Chemistry, 2012, Bajare, Swapnil et. al.
C5-Substituted Derivatives of 5-OMe-BPAT: Synthesis and Interactions with Dopamine D 2 and Serotonin 5-HT 1A Receptors
score: 0.9043507, Bioorganic & Medicinal Chemistry, 1999, Homan, Evert J. et. al.
Synthesis, in vitro, and in vivo characterization of an integrin α vβ 3-targeted molecular probe for optical imaging of tumor
score: 0.9043032, Bioorganic & Medicinal Chemistry, 2005, Burnett, Christopher A. et. al.
Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents
score: 0.90399427, Scientia Pharmaceutica, 2011, Nassar, Ekhlass et. al.
Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery
score: 0.90390641, European Journal of Medicinal Chemistry, 2010, Jain, Subheet et. al.
Enriching C-terminal peptide from endopeptidase ArgC digest for protein C-terminal analysis
score: 0.90377231, Bioorganic & Medicinal Chemistry Letters, 2012, Kuyama, Hiroki; Nakajima, Chihiro; Tanaka, Koichi
Enriching C-terminal peptide from endopeptidase ArgC digest for protein C-terminal analysis
score: 0.90377231, Bioorganic & Medicinal Chemistry Letters, 2012, Kuyama, Hiroki; Nakajima, Chihiro; Tanaka, Koichi
Enriching C-terminal peptide from endopeptidase ArgC digest for protein C-terminal analysis
score: 0.90377231, Bioorganic & Medicinal Chemistry Letters, 2012, Kuyama, Hiroki; Nakajima, Chihiro; Tanaka, Koichi
Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescens.
score: 0.90358457, Antimicrobial agents and chemotherapy, 2005, Kumar, Ayush; Worobec, Elizabeth A
Systematic analysis of metallo-β-lactamases using an automated database.
score: 0.90340481, Antimicrobial agents and chemotherapy, 2012, Widmann, Michael; Pleiss, Jürgen; Oelschlaeger, Peter
Enhanced antitumor activitiy of trans(±)-1,2-Diaminocyclo- hexaneglutamatoplatinum(II) formulated with stealth liposome
score: 0.90339178, Bioorganic & Medicinal Chemistry, 2003, Han, Insook et. al.
What's wrong with drug screening today.
score: 0.90329007, Nature chemical biology, 2007, Nolan, Garry P
Comparison in antioxidant action between α-chitosan and β-chitosan at a wide range of molecular weight and chitosan concentration
score: 0.90326141, Bioorganic & Medicinal Chemistry, 2012, Jung, Jooyeoun; Zhao, Yanyun
Comparison in antioxidant action between α-chitosan and β-chitosan at a wide range of molecular weight and chitosan concentration
score: 0.90326141, Bioorganic & Medicinal Chemistry, 2012, Jung, Jooyeoun; Zhao, Yanyun
Clinical pharmacokinetics of oral controlled-release 5-fluorocytosine.
score: 0.90325727, Antimicrobial agents and chemotherapy, 2010, Pai, Manjunath P; Bruce, Hollie; Felton, Linda A
Comparative QSAR study of phenol derivatives with the help of density functional theory
score: 0.90300722, Bioorganic & Medicinal Chemistry, 2005, Pasha, F.A.; Srivastava, H.K.; Singh, P.P.
Imidazolines as efficacious glucose-dependent stimulators of insulin secretion
score: 0.90297332, European Journal of Medicinal Chemistry, 2003, Jakobsen, Palle; Madsen, Peter; Andersen, HenrikSune
Analysis of Structure-Permeability Correlation of Nitrophenol Analogues in Newborn Rat Abdominal Skin using Semiempirical Molecular Orbital Calculation
score: 0.90296248, Bioorganic & Medicinal Chemistry, 1999, Ohkura, Kazuto; Hori, Hitoshi
Air to fat and blood to fat distribution of volatile organic compounds and drugs: Linear free energy analyses
score: 0.90276701, European Journal of Medicinal Chemistry, 2006, Abraham, Michael H.; Ibrahim, Adam
A synthetic approach to the generation of quercetin sulfates and the detection of quercetin 3′- O-sulfate as a urinary metabolite in the rat
score: 0.9027463, Bioorganic & Medicinal Chemistry, 2005, Jones, Donald J.L. et. al.
Modeling antibiotic tolerance in biofilms by accounting for nutrient limitation.
score: 0.90273296, Antimicrobial agents and chemotherapy, 2004, Roberts, Mark E; Stewart, Philip S
Continuous versus intermittent infusion of oxacillin for treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus.
score: 0.90265694, Antimicrobial agents and chemotherapy, 2009, Hughes, Darrel W et. al.
Emergence and evolution of multiply antibiotic-resistant Salmonella enterica serovar Paratyphi B D-tartrate-utilizing strains containing SGI1.
score: 0.90258106, Antimicrobial agents and chemotherapy, 2009, Djordjevic, Steven P et. al.
An enzymatic synthesis of glucuronides of azetidinone-based cholesterol absorption inhibitors
score: 0.90253899, Bioorganic & Medicinal Chemistry, 1999, Reiss, Paul; Burnett, Duane A.; Zaks, Aleksey
A protein radical cage slows photolysis of methylcobalamin in methionine synthase from Escherichia coli
score: 0.90238807, Bioorganic & Medicinal Chemistry, 1996, Jarrett, Joseph T. et. al.
Evidences for complex formation between l- dabPNA and aegPNA
score: 0.90238009, Bioorganic & Medicinal Chemistry Letters, 2008, Roviello, Giovanni N. et. al.
Synthesis and in vitro selective anti- Helicobacter pylori activity of N-substituted-2-oxo- 2H-1-benzopyran-3-carboxamides
score: 0.90224592, European Journal of Medicinal Chemistry, 2006, Chimenti, Franco et. al.
Silver and thallium(I) complexation with dibenzo-16-crown-4 1 Polytopic Cation Receptors, Part V. Part IV of this series, see ref [9]. 1 2 Preliminary results of this work have been presented: Ouchi, M.; Liu, Y.; Hakushi, T.; Shibutani, Y.; Yakabe, K.; Shono, T. 1995 International Chemical Congress of Pacific Basin Societies, Abstracts Part II. Organic Chemistry, No. 344 (1995). 2
score: 0.90215332, Bioorganic & Medicinal Chemistry, 1999, Ouchi, Mikio et. al.
Antibiotic resistance trends in enteropathogenic bacteria isolated in 1985-1987 and 1995-1998 in Barcelona.
score: 0.90212679, Antimicrobial agents and chemotherapy, 2000, Prats, G et. al.
Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group.
score: 0.90208941, Antimicrobial agents and chemotherapy, 2000, Letendre, S L; Capparelli, E V; Ellis, R J; McCutchan, J A
Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans.
score: 0.90208131, Antimicrobial agents and chemotherapy, 2008, Manoharlal, Raman et. al.
Development of a 3D pharmacophore for nonspecific ligand recognition of α1, α2, α3, α5, and α6 containing gaba A/benzodiazepine receptors
score: 0.90163775, Bioorganic & Medicinal Chemistry, 2000, Filizola, Marta; Harris, Danni L; Loew, Gilda H
Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia.
score: 0.90163445, Antimicrobial agents and chemotherapy, 2003, Chamot, Eric et. al.
Some insights into mechanism for binding and drug resistance of wild type and I50V V82A and I84V mutations in HIV-1 protease with GRL-98065 inhibitor from molecular dynamic simulations
score: 0.90162879, European Journal of Medicinal Chemistry, 2010, Hu, Guo-Dong et. al.
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I
score: 0.90145922, Bioorganic & Medicinal Chemistry, 2005, Carrico, Dora et. al.
Application of Non-Parametric Regression to Quantitative Structure–Activity Relationships
score: 0.90129067, Bioorganic & Medicinal Chemistry, 2002, Hirst, Jonathan D. et. al.
Glycosyl azides as building blocks in convergent syntheses of oligomeric lactosamine and Lewis x saccharides
score: 0.90111271, Bioorganic & Medicinal Chemistry, 1997, Bröder, Wolfgang; Kunz, Horst
Fluorescence emission properties of 8-aza analogues of caffeine, theophylline, and related N-alkyl xanthines
score: 0.90109865, Bioorganic & Medicinal Chemistry, 2009, Mędza, Grzegorz et. al.
Parallel-stranded hairpins containing 8-aminopurines. novel efficient probes for triple-helix formation
score: 0.90106658, Bioorganic & Medicinal Chemistry Letters, 2001, Aviñó, Anna et. al.
Isolation and characterization of the product of inactivation of γ-aminobutyric acid aminotransferase by gabaculine
score: 0.9009924, Bioorganic & Medicinal Chemistry, 1999, Fu, Mengmeng; Silverman, Richard B.
Enriching C-terminal peptide from endopeptidase ArgC digest for protein C-terminal analysis
score: 0.9009398, Bioorganic & Medicinal Chemistry Letters, 2012, Kuyama, Hiroki; Nakajima, Chihiro; Tanaka, Koichi
Kinetic and structural consequences of the leaving group in substrates of a class C β-lactamase
score: 0.90085013, Bioorganic & Medicinal Chemistry, 2004, Ahn, Yong-Mo; Pratt, R.F.
Pharmacodynamic evaluation of factors associated with the development of bacterial resistance in acutely ill patients during therapy.
score: 0.90084743, Antimicrobial agents and chemotherapy, 1998, Thomas, J K et. al.
Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.
score: 0.90076265, Antimicrobial agents and chemotherapy, 2000, Heep, M; Rieger, U; Beck, D; Lehn, N
Site-directed mutagenesis of the rat β 1-adrenoceptor. Involvement of Tyr 356 (7.43) in (+/–)cyanopindolol but not (+/–)[ 125Iodo]cyanopindolol binding
score: 0.90033165, European Journal of Medicinal Chemistry, 2004, Rezmann-Vitti, Linda A et. al.
Construction of peptides with nucleobase amino acids
score: 0.90021383, Bioorganic & Medicinal Chemistry, 2001, Takahashi, Tsuyoshi et. al.
Gene-specific effects of antisense phosphorodiamidate morpholino oligomer-peptide conjugates on Escherichia coli and Salmonella enterica serovar typhimurium in pure culture and in tissue culture.
score: 0.90014279, Antimicrobial agents and chemotherapy, 2006, Tilley, Lucas D et. al.
Contribution of beta-lactamases to beta-lactam susceptibilities of susceptible and multidrug-resistant Mycobacterium tuberculosis clinical isolates.
score: 0.8999964, Antimicrobial agents and chemotherapy, 1998, Segura, C; Salvadó, M; Collado, I; Chaves, J; Coira, A
Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2
score: 0.89994536, Bioorganic & Medicinal Chemistry Letters, 2007, McGinley, Chris M.; Jacquot, Cyril; van der Donk, Wilfred A.
Choosing an effective protein bioconjugation strategy.
score: 0.89992071, Nature chemical biology, 2011, Stephanopoulos, Nicholas; Francis, Matthew B
Combination antifungal therapy in treatment of murine pulmonary mucormycosis: roles of quinolones and azoles.
score: 0.89971653, Antimicrobial agents and chemotherapy, 2000, Sugar, A M; Liu, X P
Templating peptide folding on the surface of a micelle
score: 0.89971104, Bioorganic & Medicinal Chemistry Letters, 2000, Searle, Mark S.; Jourdan, Muriel
Comparison of a new triazole antifungal agent, Schering 56592, with itraconazole and amphotericin B for treatment of histoplasmosis in immunocompetent mice.
score: 0.89970877, Antimicrobial agents and chemotherapy, 1999, Connolly, P et. al.
Structure-activity relationships in a series of 3-sulfonylamino-2-(1 H)-quinolones, as new AMPA/Kainate and glycine antagonists
score: 0.89953491, Bioorganic & Medicinal Chemistry, 1995, Cordi, Alex A. et. al.
Solution and solid phase combinatorial synthesis of peptidomimetic library containing diversified α-methylated amino acids
score: 0.89910879, Bioorganic & Medicinal Chemistry Letters, 1998, Kim, Sang Woong; Shin, You Seung; Ro, Seonggu
Comparison of demetalation properties between zinc chlorin and zinc porphyrin derivatives: Effect of macrocyclic structures
score: 0.8990815, Bioorganic & Medicinal Chemistry, 2010, Saga, Yoshitaka; Hojo, Sayaka; Hirai, Yuki
Amphiphilic chitosan nanosphere: Studies on formation, toxicity, and guest molecule incorporation
score: 0.89896704, Bioorganic & Medicinal Chemistry, 2008, Yoksan, Rangrong; Chirachanchai, Suwabun
A rapid non-culture-based assay for clinical monitoring of phenotypic resistance of human immunodeficiency virus type 1 to lamivudine (3TC).
score: 0.89893774, Antimicrobial agents and chemotherapy, 1999, García Lerma, J et. al.
Parallel synthesis and nucleic acid binding properties of C(6′)-α-functionalized bicyclo-DNA
score: 0.89867631, Bioorganic & Medicinal Chemistry, 2010, Šilhár, Peter; Leumann, Christian J.
Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators
score: 0.89858644, Bioorganic & Medicinal Chemistry, 1999, Supuran, Claudiu T.; Scozzafava, Andrea
Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4.
score: 0.89841478, Antimicrobial agents and chemotherapy, 2011, Grönlund, Juha et. al.
Obtaining higher transesterification rates with subtilisin Carlsberg in nonaqueous media
score: 0.89826699, Bioorganic & Medicinal Chemistry Letters, 2004, Roy, Ipsita; Sharma, Aparna; Gupta, Munishwar N.
Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase
score: 0.89823071, Bioorganic & Medicinal Chemistry, 2000, Boger, Dale L. et. al.
Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents
score: 0.89809638, European Journal of Medicinal Chemistry, 2012, Yıldırım, Tuba et. al.
Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola
score: 0.89802931, Bioorganic & Medicinal Chemistry, 2012, Kim, Hyunjung et. al.
Synthesis and radiosynthesis of [ 18F]FPhEP, a novel α 4β 2-selective, epibatidine-based antagonist for PET imaging of nicotinic acetylcholine receptors
score: 0.89788671, Bioorganic & Medicinal Chemistry, 2006, Roger, Gaëlle et. al.
Proline–Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues
score: 0.89784537, Bioorganic & Medicinal Chemistry, 2003, Paradisi, Mario Paglialunga et. al.
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
score: 0.89781701, European Journal of Medicinal Chemistry, 2012, Di, Li et. al.
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
score: 0.89781701, European Journal of Medicinal Chemistry, 2012, Di, Li et. al.
Dose-dependent resorption of quinine after intrarectal administration to children with moderate Plasmodium falciparum malaria.
score: 0.8976676, Antimicrobial agents and chemotherapy, 2004, Pussard, Eric et. al.
Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicity.
score: 0.89751311, Antimicrobial agents and chemotherapy, 2005, Chabrier-Roselló, Yeissa et. al.
An additional 2′-ribofuranose residue at a specific position of the DNA primer prevents Its elongation by HIV-1 reverse transcriptase
score: 0.89725551, Bioorganic & Medicinal Chemistry Letters, 2002, Andreeva, O.I et. al.
4-Substituted 1,5-diarylpyrazole, analogues of celecoxib: synthesis and preliminary evaluation of biological properties
score: 0.89706913, Il Farmaco, 2003, Menozzi, Giulia et. al.
Structure and biological activity of cationic [PtLCl(DMSO)]NO 3·DMSO complex containing a chelated diaminosugar: methyl-3,4-diamino-2,3,4,6-tetradeoxy-α- l-lyxopyranoside
score: 0.89701941, European Journal of Medicinal Chemistry, 2003, Fuks, Leon et. al.
Synthesis of Photolabile Transcription Initiators and Preparation of Photocleavable Functional RNA by Transcription
score: 0.89693829, Bioorganic & Medicinal Chemistry Letters, 2012, Huang, Faqing; Shi, Yongliang
In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance.
score: 0.8969227, Antimicrobial agents and chemotherapy, 2004, da Silva Ferreira, Márcia Eliana et. al.
Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus
score: 0.89689047, Bioorganic & Medicinal Chemistry, 2005, Uckun, F.M. et. al.
In vitro and in vivo activities of gatifloxacin against Mycobacterium tuberculosis.
score: 0.89682492, Antimicrobial agents and chemotherapy, 2002, Alvirez-Freites, Enrique J et. al.
Branched-chain and unsaturated 1,7-Diaminoheptane derivatives as deoxyhypusine synthase inhibitors
score: 0.89680437, Bioorganic & Medicinal Chemistry, 1998, Lee, Young Bok; Folk, J.E.
Adenosiland: walking through adenosine receptors landscape
score: 0.89650238, European Journal of Medicinal Chemistry, 2012, Floris, Matteo et. al.
Chiral preference of l-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to d- and dl-tryptophan analogues: Their in vitro reactivity towards CT DNA, 5′-GMP and 5′-TMP
score: 0.89648977, European Journal of Medicinal Chemistry, 2010, Arjmand, Farukh; Muddassir, Mohd.; Khan, Rizwan Hasan
The porphyrin–fullerene nanoparticles to promote the ATP overproduction in myocardium: 25Mg 2+-magnetic isotope effect
score: 0.89640703, European Journal of Medicinal Chemistry, 2009, Rezayat, S.M. et. al.
Synthesis of d-labeled N-alkylmaleimides and application to quantitative peptide analysis by isotope differential mass spectrometry
score: 0.89629783, Bioorganic & Medicinal Chemistry Letters, 2001, Niwayama, Satomi; Kurono, Sadamu; Matsumoto, Hiroyuki
Emergence of resistance in normal human aerobic commensal flora during telithromycin and amoxicillin-clavulanic acid treatments.
score: 0.89625395, Antimicrobial agents and chemotherapy, 2003, Crémieux, Anne-Claude et. al.
Structural and mechanistic basis for a new mode of glycosyltransferase inhibition.
score: 0.89621326, Nature chemical biology, 2010, Pesnot, Thomas et. al.
Chemical Engineering of RNase Resistant and Catalytically Active Hammerhead Ribozymes
score: 0.89619198, Bioorganic & Medicinal Chemistry, 1997, Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis
Synthesis of heterotrimeric collagen models containing Arg residues in Y-positions and analysis of their conformational stability
score: 0.89615016, Bioorganic & Medicinal Chemistry Letters, 2004, Koide, Takaki; Nishikawa, Yoshimi; Takahara, Yoshifumi
Safety and pharmacokinetics of chimeric anti-Shiga toxin 1 and anti-Shiga toxin 2 monoclonal antibodies in healthy volunteers.
score: 0.89614106, Antimicrobial agents and chemotherapy, 2009, Bitzan, Martin et. al.
Synthesis, stereochemistry, and antimicrobial evaluation of substituted piperidin-4-one oxime ethers
score: 0.89576302, European Journal of Medicinal Chemistry, 2006, Ramalingan, C.; Park, Y.T.; Kabilan, S.
Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.
score: 0.89558992, Antimicrobial agents and chemotherapy, 2000, Torkkell, S et. al.
A screen for modulators of large T antigen’s ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication
score: 0.89552568, Antiviral Research, 2012, Seguin, Sandlin P. et. al.
Ru(η 6-arene) complexes of combretastatin-analogous oxazoles with enhanced anti-tumoral impact
score: 0.89546026, European Journal of Medicinal Chemistry, 2010, Biersack, Bernhard et. al.
Evaluation of NAD(+) -dependent DNA ligase of mycobacteria as a potential target for antibiotics.
score: 0.89545873, Antimicrobial agents and chemotherapy, 2007, Korycka-Machala, Malgorzata et. al.
Structure–activity relationships of seco-prezizaane and picrotoxane/picrodendrane terpenoids by Quasar receptor-surface modeling
score: 0.89543807, Bioorganic & Medicinal Chemistry, 2004, Schmidt, Thomas J; Gurrath, Marion; Ozoe, Yoshihisa
High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a.
score: 0.89542692, Microbiology (Reading, England), 2012, Fernández, María L Suárez et. al.
STD-NMR studies of two acceptor substrates of GlfT2, a galactofuranosyltransferase from Mycobacterium tuberculosis: Epitope mapping studies
score: 0.89534773, Bioorganic & Medicinal Chemistry, 2010, Szczepina, Monica G. et. al.
Synthesis and neuroprotective activity of bergenin derivatives with antioxidant activity
score: 0.89522349, Bioorganic & Medicinal Chemistry, 2003, Takahashi, Hironobu et. al.
Template-directed interference footprinting for RNA based on inosine-specific cleavage
score: 0.89519235, Bioorganic & Medicinal Chemistry Letters, 2000, Jaikaran, Dominic C.J.; MacMillan, Andrew M.
Antitumour activity of novel 1,10-phenanthroline and 5-amino-1,10-phenanthroline derivatives
score: 0.89501233, European Journal of Medicinal Chemistry, 2009, Wesselinova, Diana et. al.
Exploring the structure and function of the mycobacterial KatG protein using trans-dominant mutants.
score: 0.89497751, Antimicrobial agents and chemotherapy, 2003, DeVito, Joseph A; Morris, Sheldon
Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance.
score: 0.89496336, Antimicrobial agents and chemotherapy, 2001, Nunes, P A; Tenreiro, S; Sá-Correia, I
Self-complementary peptides for the formation of collagen-like triple helical supramolecules
score: 0.89492801, Bioorganic & Medicinal Chemistry Letters, 2005, Koide, Takaki et. al.
Synthesis and cellular studies of polyamine conjugates of a mercaptomethyl–carboranylporphyrin
score: 0.89481083, Bioorganic & Medicinal Chemistry, 2013, Bhupathiraju, N.V.S. Dinesh K.; Vicente, M. Graça H.
The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA
score: 0.89480602, Bioorganic & Medicinal Chemistry Letters, 1998, Kumar, Ravindra et. al.
Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspofungin.
score: 0.89476447, Antimicrobial agents and chemotherapy, 2010, Decosterd, Laurent Arthur et. al.
ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate.
score: 0.89473565, Antimicrobial agents and chemotherapy, 2003, Pletz, M W et. al.
Synthesis of 26,27-bisnorcastasterone analogs and analysis of conformation–activity relationship for brassinolide-like activity
score: 0.89471404, Bioorganic & Medicinal Chemistry, 2006, Yamamoto, Shuji et. al.
Extended-spectrum beta-lactamases in enterobacteriaceae in Buenos Aires, Argentina, public hospitals.
score: 0.89470351, Antimicrobial agents and chemotherapy, 2003, Quinteros, M et. al.
Exploring the conformation of bilirubins with natural and unnatural analogues: use of positional and bridged isomers of bilirubin IXα
score: 0.89441489, Bioorganic & Medicinal Chemistry, 1999, Kogan, Marcelo J et. al.
Attributable hospital cost and antifungal treatment of invasive fungal diseases in high-risk hematology patients: an economic modeling approach.
score: 0.89425848, Antimicrobial agents and chemotherapy, 2011, Ananda-Rajah, Michelle R et. al.
Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins
score: 0.89410486, Bioorganic & Medicinal Chemistry, 2003, Trova, Michael P et. al.
Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction
score: 0.89403271, Bioorganic & Medicinal Chemistry Letters, 2006, Thavaneswaran, Shanti; Scammells, Peter J.
Chemical ecology of astigmatid mites—XLV. (2 R,3 R)-Epoxyneral: Sex pheromone of the acarid mite Caloglyphus sp. (acarina: acaridae) 1
score: 0.89401621, Bioorganic & Medicinal Chemistry, 1996, Mori, Naoki; Kuwahara, Yasumasa; Kurosa, Kazuyoshi
The initial 96 hours of invasive pulmonary aspergillosis: histopathology, comparative kinetics of galactomannan and (1->3) β-d-glucan and consequences of delayed antifungal therapy.
score: 0.89397373, Antimicrobial agents and chemotherapy, 2010, Hope, William W et. al.
Comparison of QSPR models of octanol/water partition coefficient for vitamins and non vitamins
score: 0.89384674, European Journal of Medicinal Chemistry, 2006, Raska, I.; Toropov, A.
QacA multidrug efflux pump from Staphylococcus aureus: comparative analysis of resistance to diamidines, biguanidines, and guanylhydrazones.
score: 0.89379866, Antimicrobial agents and chemotherapy, 1998, Mitchell, B A; Brown, M H; Skurray, R A
The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.
score: 0.89360609, Antimicrobial agents and chemotherapy, 2011, Wang, Liya; Sun, Ren; Eriksson, Staffan
Two related neurokinin-1 receptor antagonists have overlapping but different binding sites
score: 0.89350726, Bioorganic & Medicinal Chemistry, 1998, Greenfeder, Scott et. al.
Acridone-tagged DNA as a new probe for DNA detection by fluorescence resonance energy transfer and for mismatch DNA recognition
score: 0.89339438, Bioorganic & Medicinal Chemistry, 2008, Hagiwara, Yasuhisa et. al.
Synthesis of the Nanomolar Photoaffinity GABA B Receptor Ligand CGP 71872 Reveals Diversity in the Tissue Distribution of GABA B Receptor Forms
score: 0.89338789, Bioorganic & Medicinal Chemistry, 1999, Belley, Michel et. al.
In vitro activities of benzimidazoles against Echinococcus multilocularis metacestodes.
score: 0.89328841, Antimicrobial agents and chemotherapy, 1998, Jura, H; Bader, A; Frosch, M
Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites
score: 0.89326341, Bioorganic & Medicinal Chemistry, 2000, Ronsisvalle, Giuseppe et. al.
Gentamicin increases the efficacy of vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model.
score: 0.8932408, Antimicrobial agents and chemotherapy, 2002, Cottagnoud, Philippe et. al.
Regional prophylaxis with teicoplanin in monolateral or bilateral total knee replacement: an open study.
score: 0.8932141, Antimicrobial agents and chemotherapy, 2000, de Lalla, F et. al.
Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase α
score: 0.89318034, Bioorganic & Medicinal Chemistry, 2005, Kuriyama, Isoko et. al.
Long-chain polyamines (oligoamines) exhibit strong cytotoxicities against human prostate cancer cells
score: 0.89312714, Bioorganic & Medicinal Chemistry, 2003, Valasinas, Aldonia et. al.
Physico-chemical characterization of disoxaril–dimethyl-β-cyclodextrin inclusion complex and in vitro permeation studies
score: 0.89303731, European Journal of Medicinal Chemistry, 2006, Ventura, Cinzia Anna et. al.
10-(2-Benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid
score: 0.89299763, Bioorganic & Medicinal Chemistry, 2003, Marsilje, Thomas H et. al.
Synthetic fluorescent sensors for studying the cell biology of metals.
score: 0.89296559, Nature chemical biology, 2008, Domaille, Dylan W; Que, Emily L; Chang, Christopher J
Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]tria-zolo[4,3-a]quinoxalines as inhibitors of TNF-α and IL-6
score: 0.89294201, European Journal of Medicinal Chemistry, 2012, Guirado, Antonio et. al.
An overview of inhibitors of Na +/H + exchanger
score: 0.89283139, European Journal of Medicinal Chemistry, 2003, Masereel, B.; Pochet, L.; Laeckmann, D.
Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
score: 0.89261845, Antimicrobial agents and chemotherapy, 2005, Bauer, Larry A et. al.
New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase β
score: 0.89252275, Bioorganic & Medicinal Chemistry, 2004, Chaturvedula, V.S. Prakash et. al.
Influence of enantiomers of 1-naphthylalanine in position 2 of VAVP and dVAVP on their pharmacological properties
score: 0.8924333, European Journal of Medicinal Chemistry, 2005, Derdowska, Izabela et. al.
Design and synthesis of some substituted 1 H-pyrazolyl-thiazolo[4,5- d]pyrimidines as anti-inflammatory–antimicrobial Agents
score: 0.8924175, European Journal of Medicinal Chemistry, 2003, Bekhit, Adnan A et. al.
Molecular evaluation of the plasma membrane proton pump from Aspergillus fumigatus.
score: 0.8923428, Antimicrobial agents and chemotherapy, 2002, Burghoorn, Henriette P et. al.
Synthesis and in vitro characterization of trans- and cis18F-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-Methyl-D-Aspartate receptor
score: 0.89231664, European Journal of Medicinal Chemistry, 2012, Koudih, Radouane et. al.
Photobactericidal plastic films based on cellulose esterified by chloroacetate and a cationic porphyrin
score: 0.89217554, Bioorganic & Medicinal Chemistry, 2008, Krouit, Mohammed; Granet, Robert; Krausz, Pierre
Antitumor activity studies of newly synthesized N-salicyloyl- N′-( p-hydroxybenzthioyl)hydrazine and its Copper(II) complex both in vivo and in vitro
score: 0.89211611, Bioorganic & Medicinal Chemistry, 1997, Singh, N.K. et. al.
Raymond U. Lemieux
score: 0.8920288, Bioorganic & Medicinal Chemistry, 1996,
Early curative applications of the aminoglycoside WR279396 on an experimental Leishmania major-loaded cutaneous site do not impair the acquisition of immunity.
score: 0.8919906, Antimicrobial agents and chemotherapy, 2010, Lecoeur, Hervé et. al.
( Z, E)- α-Farnesene—An electroantennogram-active component of Maladera matrida volatiles
score: 0.89185397, Bioorganic & Medicinal Chemistry, 1996, Yarden, Gal; Shani, Arnon; Leal, Walter Soares
Pharmacophore Elucidation and Molecular Docking Studies on 5-Phenyl-1-(3-pyridyl)-1 H -1,2,4-triazole-3-carboxylic Acid Derivatives as COX-2 Inhibitors
score: 0.89180571, Scientia Pharmaceutica, 2010, Lindner, Marc; Sippl, Wolfgang; Radwan, Awwad A.
Nonthermal atmospheric plasma rapidly disinfects multidrug-resistant microbes by inducing cell surface damage.
score: 0.89171272, Antimicrobial agents and chemotherapy, 2012, Kvam, Erik; Davis, Brian; Mondello, Frank; Garner, Allen L
QSAR study of carboxylic acid derivatives as HIV-1 Integrase inhibitors
score: 0.89169549, European Journal of Medicinal Chemistry, 2010, Cheng, Zhengjun; Zhang, Yuntao; Fu, Weizhong
Synthesis and evaluation of double bond substituted combretastatins
score: 0.89159031, European Journal of Medicinal Chemistry, 2005, Hadfield, John A. et. al.
Synthesis and chain length–anti-HIV activity relationship of fully N- and O-sulfated homooligomers of tyrosine
score: 0.89154698, Bioorganic & Medicinal Chemistry, 2001, Ueki, Masaaki et. al.
Trends in antifungal drug susceptibility of Cryptococcus neoformans isolates in the United States: 1992 to 1994 and 1996 to 1998.
score: 0.89124559, Antimicrobial agents and chemotherapy, 2001, Brandt, M E et. al.
5-[4-(3,3-Dimethylbutoxycarbonyl)phenyl]-4-pentynoic acid and its derivatives inhibit ionotropic γ-aminobutyric acid receptors by binding to the 4′-ethynyl-4- n-propylbicycloorthobenzoate site
score: 0.89107926, Bioorganic & Medicinal Chemistry, 2000, Hamano, Hiroshi et. al.
Synthesis and characterization of polyester conjugates of ciprofloxacin
score: 0.89085889, European Journal of Medicinal Chemistry, 2010, Sobczak, Marcin
Corrigendum to “Design and synthesis of 4-methoxyphenylacetic acid esters as 15-lipoxygenase inhibitors and SAR comparative studies of them” [Bioorg. Med. Chem. 17 (2009) 2327]
score: 0.89060243, Bioorganic & Medicinal Chemistry, 2010, Sadeghian, Hamid et. al.
Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones
score: 0.89053409, European Journal of Medicinal Chemistry, 2004, Khalaj, Ali et. al.
Synthesis and In vitro characterization of a tissue-Selective fullerene: vectoring C 60(OH) 16AMBP to mineralized bone
score: 0.89039116, Bioorganic & Medicinal Chemistry, 2002, Gonzalez, Kelly A et. al.
QSAR studies on the activation of the human carbonic anhydrase cytosolic isoforms I and II and secretory isozyme VI with amino acids and amines
score: 0.88998697, Bioorganic & Medicinal Chemistry, 2007, Singh, Jyoti et. al.
Assessment of antifungal activities of fluconazole and amphotericin B administered alone and in combination against Candida albicans by using a dynamic in vitro mycotic infection model.
score: 0.88998188, Antimicrobial agents and chemotherapy, 1998, Lewis, R E et. al.
Conformationally-restricted vigabatrin analogs as irreversible and reversible inhibitors of γ-aminobutyric acid aminotransferase
score: 0.88991906, Bioorganic & Medicinal Chemistry, 2004, Pan, Yue; Calvert, Kristi; Silverman, Richard B.
Synthesis of newer thiadiazolyl and thiazolidinonyl quinazolin-4(3 H)-ones as potential anticonvulsant agents
score: 0.88983937, European Journal of Medicinal Chemistry, 2002, Archana, ; Srivastava, V.K; Kumar, Ashok
SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells
score: 0.88972452, Bioorganic & Medicinal Chemistry, 2012, Galindo, José L.G. et. al.
SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells
score: 0.88972452, Bioorganic & Medicinal Chemistry, 2012, Galindo, José L.G. et. al.
SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells
score: 0.88972452, Bioorganic & Medicinal Chemistry, 2012, Galindo, José L.G. et. al.
Synthesis and evaluation of a novel E-ring modified α-hydroxy keto ether analogue of camptothecin
score: 0.8896932, Bioorganic & Medicinal Chemistry, 2002, Du, Wu et. al.
Effect of the complexation with cyclodextrins on the in vitro antiviral activity of ganciclovir against Human Cytomegalovirus
score: 0.88944126, Bioorganic & Medicinal Chemistry, 2001, Nicolazzi, Céline et. al.
Identification of high-affinity PB1-derived peptides with enhanced affinity to the PA protein of influenza A virus polymerase.
score: 0.88932317, Antimicrobial agents and chemotherapy, 2011, Wunderlich, Kerstin et. al.
SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia.
score: 0.88922562, Antimicrobial agents and chemotherapy, 2002, Li, Xian-Zhi; Zhang, Li; Poole, Keith
Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects
score: 0.88910348, Bioorganic & Medicinal Chemistry, 1998, Skjærbæk, Niels et. al.
Boc-lysinated-betulonic acid: A potent, anti-prostate cancer agent
score: 0.88894034, Bioorganic & Medicinal Chemistry, 2006, Saxena, Brij B. et. al.
Perspectives in designing anti aggregation agents as Alzheimer disease drugs
score: 0.88876921, European Journal of Medicinal Chemistry, 2009, Yadav, A.; Sonker, M.
Synthetic ion channels
score: 0.88872424, Bioorganic & Medicinal Chemistry, 2004, Koert, Ulrich
Synthesis, cytotoxicity and DNA binding levels of tri-functional mononuclear platinum(II) complexes
score: 0.88868049, European Journal of Medicinal Chemistry, 2008, Zhang, Jinchao et. al.
Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent
score: 0.8885942, Bioorganic & Medicinal Chemistry Letters, 2012, Pandey, Suresh K. et. al.
Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent
score: 0.8885942, Bioorganic & Medicinal Chemistry Letters, 2012, Pandey, Suresh K. et. al.
Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs
score: 0.88815736, Bioorganic & Medicinal Chemistry, 2012, Hang, Brian I. et. al.
Strong in vitro activities of two new rifabutin analogs against multidrug-resistant Mycobacterium tuberculosis.
score: 0.88806095, Antimicrobial agents and chemotherapy, 2010, García, Ana-Belén et. al.
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
score: 0.88790005, Bioorganic & Medicinal Chemistry, 2006, Zbinden, Katrin Groebke et. al.
Antiallergic activities of rabdosiin and its related compounds: chemical and biochemical evaluations
score: 0.88788817, Bioorganic & Medicinal Chemistry, 1998, Ito, Hisatomi et. al.
Synthesis and physical characterization of a P 1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases
score: 0.88764126, Bioorganic & Medicinal Chemistry, 2002, Furlong, Stephen T. et. al.
Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cr(III), Mn(III) and Fe(III) macrocyclic complexes
score: 0.88760968, European Journal of Medicinal Chemistry, 2012, Kumar, Gajendra et. al.
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes.
score: 0.88739615, Antimicrobial agents and chemotherapy, 2001, Ganoza, M C; Kiel, M C
Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis
score: 0.88726772, Bioorganic & Medicinal Chemistry, 2005, Tsogoeva, Svetlana B. et. al.
Taxol derivatives are selective inhibitors of DNA polymerase α
score: 0.88708052, Bioorganic & Medicinal Chemistry, 2004, Oshige, Masahiko et. al.
Conformational studies of dithymidine boranomonophosphate diastereoisomers
score: 0.88685498, Bioorganic & Medicinal Chemistry, 1997, Li, Hong; Huang, Faqing; Shaw, Barbara Ramsay
Prediction of air to liver partition coefficient for volatile organic compounds using QSAR approaches
score: 0.88666572, European Journal of Medicinal Chemistry, 2010, Dashtbozorgi, Zahra; Golmohammadi, Hassan
Evolving biosynthetic tangos negotiate mechanistic landscapes.
score: 0.88619864, Nature chemical biology, 2008, Austin, Michael B; O'Maille, Paul E; Noel, Joseph P
Real-time reverse transcription-PCR quantification of cytokine mRNA expression in golden Syrian hamster infected with Leishmania infantum and treated with a new amphotericin B formulation.
score: 0.88604615, Antimicrobial agents and chemotherapy, 2006, Rama Iñiguez, S et. al.
Photoaffinity study of the cellular interactions of ilimaquinone
score: 0.88559846, Bioorganic & Medicinal Chemistry, 1998, Radeke, Heike S.; Snapper, Marc L.
N-2-(Azol-1(2)-yl)ethyliminodiacetic acids: a novel series of Gd(III) chelators as T 2 relaxation agents for magnetic resonance imaging
score: 0.88514647, Bioorganic & Medicinal Chemistry, 1999, López, Pilar et. al.
Antifungal protein PAF severely affects the integrity of the plasma membrane of Aspergillus nidulans and induces an apoptosis-like phenotype.
score: 0.8851391, Antimicrobial agents and chemotherapy, 2005, Leiter, Eva et. al.
Synthesis and anti-microbial activities of choline-like quaternary ammonium chlorides
score: 0.88501876, European Journal of Medicinal Chemistry, 2003, Pernak, Juliusz; Chwała, Przemysław
Bioengineering functional copolymers. XXI. Synthesis of a novel end carboxyl-trithiocarbonate functionalized poly(maleic anhydride) and its interaction with cancer cells
score: 0.88497858, Bioorganic & Medicinal Chemistry, 2012, Rzayev, Zakir M.O.; Tűrk, Mustafa; Söylemez, Ernur A.
New insights into the conformational requirements of B2 Bradykinin Antagonism
score: 0.88497268, Bioorganic & Medicinal Chemistry, 1998, Filizola, Marta et. al.
Covalent binding of the 13C-labeled skin sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a model peptide and glutathione
score: 0.88492223, Bioorganic & Medicinal Chemistry Letters, 2004, Alvarez-Sánchez, Rubén et. al.
Construction of two-stranded α-helix peptides based on influenza virus M1 protein selectively bound to RNA
score: 0.88482618, Bioorganic & Medicinal Chemistry Letters, 2000, Kuribayashi, Hideto et. al.
Cysteinyl-flavan-3-ol Conjugates from Grape Procyanidins. Antioxidant and Antiproliferative Properties
score: 0.88479704, Bioorganic & Medicinal Chemistry, 2002, Torres, J.L et. al.
New synthesis of (±)-α-CMBHC and its confirmation as a metabolite of α-tocopherol (vitamin E)
score: 0.88466645, Bioorganic & Medicinal Chemistry, 2001, Pope, Simon A.S et. al.
Safety and pharmacokinetics of once-daily regimens of soft-gel capsule saquinavir plus minidose ritonavir in human immunodeficiency virus-negative adults.
score: 0.88449647, Antimicrobial agents and chemotherapy, 2000, Kilby, J M et. al.
Pentopyranosyl oligonucleotide systems. Part 11: systems with shortened backbones: ( d)-β-ribopyranosyl-(4′→3′)- and ( l)-α-lyxopyranosyl-(4′→3′)-oligonucleotides
score: 0.88442808, Bioorganic & Medicinal Chemistry, 2001, Wippo, Harald et. al.
Therapeutic efficacy of liposome-encapsulated gentamicin in rat Klebsiella pneumoniae pneumonia in relation to impaired host defense and low bacterial susceptibility to gentamicin.
score: 0.88442498, Antimicrobial agents and chemotherapy, 2001, Schiffelers, R M et. al.
Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity
score: 0.88411099, Bioorganic & Medicinal Chemistry, 2004, Ilies, Marc A et. al.
Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes
score: 0.88410329, Bioorganic & Medicinal Chemistry, 2000, Collina, Simona et. al.
A concise route to triazolobenzodiazepine derivatives via a one-Pot alkyne-Azide cycloaddition reaction
score: 0.88404539, Bioorganic & Medicinal Chemistry Letters, 2002, Thomas, Andrew W
Design, synthesis and antihistaminic (H 1) activity of some condensed 3-aminopyrimidin-4(3 H )-ones
score: 0.88394994, European Journal of Medicinal Chemistry, 2000, Shishoo, Chamanlal J et. al.
Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia.
score: 0.88391677, Antimicrobial agents and chemotherapy, 2003, Edelstein, Paul H; Weiss, William J; Edelstein, Martha A C
Purification and partial amino acid sequences of the enzyme vinorine synthase involved in a crucial step of ajmaline biosynthesis
score: 0.88366247, Bioorganic & Medicinal Chemistry, 2004, Gerasimenko, Irina et. al.
Nevirapine significantly reduces the levels of racemic methadone and (R)-methadone in human immunodeficiency virus-infected patients.
score: 0.88352529, Antimicrobial agents and chemotherapy, 2004, Stocker, Hartmut et. al.
Microbial metabolism of 1-aminoanthracene by Beauveria bassiana
score: 0.8835003, Bioorganic & Medicinal Chemistry, 2008, Zhan, Jixun; Gunatilaka, A.A. Leslie
Synthesis, cytotoxicity and DNA-binding levels of ammine/propylamine platinum(II) complexes with carboxylates
score: 0.88348587, European Journal of Medicinal Chemistry, 2007, Zhang, Jinchao; Zhao, Xuejun
The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity
score: 0.88340939, Bioorganic & Medicinal Chemistry, 2006, Giménez, Diana et. al.
Mechanism of hemolysis and erythrocyte transformation caused by lipogrammistin-A, a lipophilic and acylated cyclic polyamine from the skin secretion of soapfishes (Grammistidae)
score: 0.88336184, Bioorganic & Medicinal Chemistry, 1999, Kobayashi, Yoshimasa; Onuki, Hiroyuki; Tachibana, Kazuo
A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients.
score: 0.88334815, Antimicrobial agents and chemotherapy, 1999, Piscitelli, S C et. al.
Poly(D,L-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice.
score: 0.88333426, Antimicrobial agents and chemotherapy, 2007, Lecaroz, M C et. al.
Synthesis, labeling, and biological evaluation of halogenated 2-quinolinecarboxamides as potential radioligands for the visualization of peripheral benzodiazepine receptors
score: 0.88330986, Bioorganic & Medicinal Chemistry, 2006, Cappelli, Andrea et. al.
Protein-based alignment in 3D QSAR of 26 indole inhibitors of human pancreatic phospholipase A 2
score: 0.88329672, European Journal of Medicinal Chemistry, 2001, Pintore, Marco et. al.
Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human α 1-acid glycoprotein
score: 0.88324124, Bioorganic & Medicinal Chemistry, 2004, Zsila, Ferenc; Bikádi, Zsolt; Simonyi, Miklós
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK
score: 0.88320778, Bioorganic & Medicinal Chemistry, 2006, Xu, Ya-ming et. al.
Effects of glycosylation on fragments of tumour associated human epithelial mucin MUC1
score: 0.882941, Bioorganic & Medicinal Chemistry, 1998, Braun, Peter et. al.
A multicenter phase I/II dose escalation study of single-dose cidofovir gel for treatment of recurrent genital herpes.
score: 0.88286938, Antimicrobial agents and chemotherapy, 1998, Sacks, S L et. al.
Methylation of l- trans-2,4-Pyrrolidine Dicarboxylate Converts the Glutamate Transport Inhibitor from a Substrate to a Non-substrate Inhibitor
score: 0.88286252, Bioorganic & Medicinal Chemistry, 2002, Esslinger, C.Sean et. al.
Global optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain
score: 0.88278045, Bioorganic & Medicinal Chemistry, 2003, Long, Ya-Qiu; Lung, Feng-Di T.; Roller, Peter P.
Synthesis, BiologicalEvaluation, and Structure–ActivityRelationships of Novel Substituted N -Phenyl UreidobenzenesulfonateDerivatives Blocking Cell Cycle Progression in S-Phase and InducingDNA Double-Strand Breaks
score: 0.88261237, Journal of Medicinal Chemistry, 2012, Turcotte, Vanessa et. al.
Native N -glycopeptide thioester synthesis through N → S acyl transfer
score: 0.88252358, Bioorganic & Medicinal Chemistry Letters, 2011, Premdjee, Bhavesh; Adams, Anna L.; Macmillan, Derek
Prospective, open-label investigation of the pharmacokinetics of daptomycin during cardiopulmonary bypass surgery.
score: 0.88237876, Antimicrobial agents and chemotherapy, 2011, Nguyen, Megan H et. al.
Amprenavir and efavirenz pharmacokinetics before and after the addition of nelfinavir, indinavir, ritonavir, or saquinavir in seronegative individuals.
score: 0.88228653, Antimicrobial agents and chemotherapy, 2005, Morse, Gene D et. al.
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors.
score: 0.88223885, ChemMedChem, 2009, Falchi, Federico et. al.
Binding interactions of vancomycin tracers with a bacterial cell wall peptidoglycan analogue
score: 0.88220789, Bioorganic & Medicinal Chemistry Letters, 2000, Adamczyk, Maciej et. al.
Toward preparation of antibody-based imaging probe libraries for dual-modality positron emission tomography and fluorescence imaging
score: 0.88214076, Bioorganic & Medicinal Chemistry, 2009, Xu, Heng et. al.
Azulene derivatives as TXA 2/PGH 2 receptor antagonists—II. Synthesis and biological activity of 6-mono- and 6-dihydroxylated-isopropylazulenes
score: 0.88209939, Bioorganic & Medicinal Chemistry, 1996, Yokota, Masayuki et. al.
Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration.
score: 0.8819742, Antimicrobial agents and chemotherapy, 2004, Walsh, Thomas J et. al.
2,2′-Bipyridinebutyldithiocarbamatoplatinum(II) and palladium(II) complexes: Synthesis, characterization, cytotoxicity, and rich DNA-binding studies
score: 0.88183362, Bioorganic & Medicinal Chemistry, 2008, Mansouri-Torshizi, Hassan et. al.
Novel rhenium complexes derived from α-tropanol as potential ligands for the dopamine transporter
score: 0.88179661, Bioorganic & Medicinal Chemistry, 1998, Hoepping, Alexander et. al.
Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs
score: 0.88178334, Bioorganic & Medicinal Chemistry, 2004, Zhang, Xue Wu; Yap, Yee Leng
Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana
score: 0.88161081, Bioorganic & Medicinal Chemistry, 2003, Chattopadhyay, Sunil K et. al.
N, N′-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA
score: 0.88159068, Bioorganic & Medicinal Chemistry, 2005, Suda, Hitoshi et. al.
Expanding the recognition of the minor groove of DNA by incorporation of β-alanine in hairpin polyamides
score: 0.88154595, Bioorganic & Medicinal Chemistry, 2001, Wang, Clay C.C.; Ellervik, Ulf; Dervan, Peter B.
Development of affinity chromatography using a bioactive peptide as a ligand
score: 0.88153785, Bioorganic & Medicinal Chemistry, 2006, Furuya, Minoru et. al.
Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia
score: 0.88140128, Bioorganic & Medicinal Chemistry, 2004, Das, Tapas et. al.
Biologically active oligodeoxyribonucleotides. Part 11: The least phosphate-modification of quadruplex-forming hexadeoxyribonucleotide TGGGAG, bearing 3′- and 5′-end-modification, with anti-HIV-1 activity
score: 0.88131504, Bioorganic & Medicinal Chemistry, 1998, Koizumi, Makoto et. al.
Reactivity of (1-->3)-beta-d-glucan assay with commonly used intravenous antimicrobials.
score: 0.8812661, Antimicrobial agents and chemotherapy, 2006, Marty, Francisco M et. al.
Combination therapy with paromomycin-associated stearylamine-bearing liposomes cures experimental visceral leishmaniasis through Th1-biased immunomodulation.
score: 0.88101718, Antimicrobial agents and chemotherapy, 2011, Banerjee, Antara; De, Manjarika; Ali, Nahid
Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages
score: 0.88099592, Bioorganic & Medicinal Chemistry, 2001, Yu, Dong et. al.
Signaling pathways and effector mechanisms pre-programmed cell death
score: 0.88097731, Bioorganic & Medicinal Chemistry, 2001, Blatt, Neal B.; Glick, Gary D.
Affinity labeling of the nuclear vitamin D receptor with nonsteroidal alkylating agents
score: 0.88096966, Bioorganic & Medicinal Chemistry Letters, 2003, Fernández-Gacio, Ana et. al.
Unexpected role of 5-OH in DPPH radical-scavenging activity of 4-thiaflavans. Revealed by theoretical calculations
score: 0.88093649, Bioorganic & Medicinal Chemistry Letters, 2004, Wang, Lan-Fen; Zhang, Hong-Yu
Direct measurement of pyrimidine C6-hydrate stability
score: 0.88089604, Bioorganic & Medicinal Chemistry, 2001, Nolan Carter, K.; Greenberg, Marc M.
Physicochemical and biological study of selected hydrophobic polyethylenimine-based polycationic liposomes and their complexes with DNA
score: 0.88077716, Bioorganic & Medicinal Chemistry, 2007, Masotti, Andrea et. al.
Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies
score: 0.8807576, European Journal of Medicinal Chemistry, 2008, Cheng, Yiyun; Li, Mingzhong; Xu, Tongwen
The aminoglycoside 6'-N-acetyltransferase type Ib encoded by Tn1331 is evenly distributed within the cell's cytoplasm.
score: 0.88068882, Antimicrobial agents and chemotherapy, 2003, Dery, Ken J et. al.
Acetyltransfer in natural product biosynthesis––functional cloning and molecular analysis of vinorine synthase
score: 0.88056945, Bioorganic & Medicinal Chemistry, 2004, Bayer, Anja; Ma, Xueyan; Stöckigt, Joachim
Is in vitro antibiotic combination more effective than single-drug therapy against anthrax?
score: 0.88055338, Antimicrobial agents and chemotherapy, 2005, Athamna, Abed et. al.
Identification and validation of protein targets of bioactive small molecules
score: 0.88054093, Bioorganic & Medicinal Chemistry, 2012, Titov, Denis V.; Liu, Jun O.
Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar typhimurium.
score: 0.88050439, Antimicrobial agents and chemotherapy, 2000, Giraud, E; Cloeckaert, A; Kerboeuf, D; Chaslus-Dancla, E
Synthesis, Characterization and Antitumor Studies of Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) Complexes of N-Salicyloyl- N′- o-hydroxythiobenzhydrazide
score: 0.88048669, Bioorganic & Medicinal Chemistry, 2002, Shrivastav, Anuraag; Singh, Nand K.; Singh, Sukh Mahendra
Bactericidal activity of micromolar N-chlorotaurine: evidence for its antimicrobial function in the human defense system.
score: 0.88023246, Antimicrobial agents and chemotherapy, 2000, Nagl, M; Hess, M W; Pfaller, K; Hengster, P; Gottardi, W
Activities of the oxazolidinones linezolid and eperezolid in experimental intra-abdominal abscess due to Enterococcus faecalis or vancomycin-resistant Enterococcus faecium.
score: 0.8801855, Antimicrobial agents and chemotherapy, 1999, Schülin, T et. al.
Safety, tolerance, and pharmacokinetics of high-dose liposomal amphotericin B (AmBisome) in patients infected with Aspergillus species and other filamentous fungi: maximum tolerated dose study.
score: 0.87997326, Antimicrobial agents and chemotherapy, 2001, Walsh, T J et. al.
Deoxynucleic guanidine
score: 0.87993021, Bioorganic & Medicinal Chemistry, 2004, Challa, Hemavathi; Bruice, Thomas C
Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4 H-1,4-benzothiazines as antimicrobial agents
score: 0.87986171, Bioorganic & Medicinal Chemistry, 2006, Rathore, Bhawani Singh; Kumar, M.
2-Aminopurine as a real-time probe of enzymatic cleavage and inhibition of hammerhead ribozymes
score: 0.87985052, Bioorganic & Medicinal Chemistry, 2001, Kirk, Sarah R; Luedtke, Nathan W; Tor, Yitzhak
A fungal ketoreductase domain that displays substrate-dependent stereospecificity
score: 0.87975068, Nature chemical biology, 2011, Zhou, Hui et. al.
P-loop catalytically assisting the enzymatic cleavage of single-stranded DNA
score: 0.87972251, Bioorganic & Medicinal Chemistry, 2003, Okamoto, Akimitsu; Tanabe, Kazuhito; Saito, Isao
Probing the ultra-high resolution structure of aldose reductase with molecular modelling and noncovalent mass spectrometry
score: 0.87970554, Bioorganic & Medicinal Chemistry, 2004, Darmanin, Connie et. al.
Effect of amphotericin B on larval growth of Echinococcus multilocularis.
score: 0.87965104, Antimicrobial agents and chemotherapy, 2003, Reuter, Stefan et. al.
Cytotoxicity of enantiomers of gossypol Schiff’s bases and optical stability of gossypolone
score: 0.87963039, European Journal of Medicinal Chemistry, 2004, Dao, Vi-Thuy et. al.
3,4- trans-4-Aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates—new group of potential cardiotonic drugs
score: 0.87956413, European Journal of Medicinal Chemistry, 2005, Krauze, A. et. al.
The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.
score: 0.87934799, Antimicrobial agents and chemotherapy, 2005, Miranda, Luis R et. al.
Studies on the profile of immunostimulant activities of modified iridoid glycosides 1 1 CDRI Communication no. 5707.
score: 0.87933452, Bioorganic & Medicinal Chemistry, 1998, Mathad, Vijayavitthal T et. al.
Cu(I)–Glutathione complex: A potential source of superoxide radicals generation
score: 0.87931712, Bioorganic & Medicinal Chemistry, 2008, Speisky, Hernán et. al.
Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides.
score: 0.87916916, Antimicrobial agents and chemotherapy, 2006, Vylkova, Slavena et. al.
Prevention of human rhinovirus infection by multivalent fab molecules directed against ICAM-1.
score: 0.8789179, Antimicrobial agents and chemotherapy, 2003, Charles, Catherine H et. al.
Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity
score: 0.87881716, European Journal of Medicinal Chemistry, 2001, Turan-Zitouni, Gülhan et. al.
Isolation of a Lactobacillus salivarius strain and purification of its bacteriocin, which is inhibitory to Campylobacter jejuni in the chicken gastrointestinal system.
score: 0.87873805, Antimicrobial agents and chemotherapy, 2006, Stern, N J et. al.
Pyrrolo[3,4- c]-β-carboline-diones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase
score: 0.8787096, European Journal of Medicinal Chemistry, 2000, Teller, Steffen et. al.
Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3′ allyl end and at the phenyl ring of the cinnamyl chain on μ-receptor affinity and opioid antinociception
score: 0.878547, Bioorganic & Medicinal Chemistry, 2003, Pinna, Gérard Aimè et. al.
Diastereoselective synthesis of ( R)-(alkyl)-β- d-galactopyranoside by using β-galactosidase ( Aspergillus oryzae) in low-water media
score: 0.87853338, Bioorganic & Medicinal Chemistry Letters, 2008, Majumder, Abir B.; Singh, Bhupender; Gupta, Munishwar N.
Synthesis and structure–activity relationship of ethacrynic acid analogues on glutathione-s-transferase P1-1 activity inhibition
score: 0.8781427, Bioorganic & Medicinal Chemistry, 2005, Zhao, Guisen et. al.
Specific inhibition of coxsackievirus B3 translation and replication by phosphorothioate antisense oligodeoxynucleotides.
score: 0.87802315, Antimicrobial agents and chemotherapy, 2001, Wang, A et. al.
Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi
score: 0.87800595, European Journal of Medicinal Chemistry, 2006, Silva, Raphael S.F. et. al.
Assignment of absolute stereochemistry to an insect pheromone by chiral amplification
score: 0.87757502, Bioorganic & Medicinal Chemistry, 1996, Shi, Xiongwei; Leal, Walter S.; Meinwald, Jerrold
In vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazole.
score: 0.87719875, Antimicrobial agents and chemotherapy, 1999, Torres-Rodríguez, J M et. al.
Enhanced cytotoxicity of a polymer–drug conjugate with triple payload of paclitaxel
score: 0.8770925, Bioorganic & Medicinal Chemistry, 2009, Erez, Rotem et. al.
Chlorine atom substitution influences radical scavenging activity of 6-chromanol
score: 0.87680771, Bioorganic & Medicinal Chemistry, 2012, Inami, Keiko et. al.
Chlorine atom substitution influences radical scavenging activity of 6-chromanol
score: 0.87680771, Bioorganic & Medicinal Chemistry, 2012, Inami, Keiko et. al.
Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site
score: 0.87677014, Bioorganic & Medicinal Chemistry, 2012, Abe, Yukiko et. al.
Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as Non-TZD Peroxisome Proliferator-Activated Receptor γ (PPARγ) agonist
score: 0.87652329, European Journal of Medicinal Chemistry, 2012, Bajare, Swapnil et. al.
A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis
score: 0.87642832, Bioorganic & Medicinal Chemistry, 1999, Spivak, David A. et. al.
Formation of a diimino-imidazole nucleoside from 2′-deoxyguanosine by singlet oxygen generated by methylene blue photooxidation
score: 0.87638846, Bioorganic & Medicinal Chemistry, 2003, Suzuki, Toshinori; Friesen, Marlin D; Ohshima, Hiroshi
In vivo effect of alpha(1)-acid glycoprotein on pharmacokinetics of amprenavir, a human immunodeficiency virus protease inhibitor.
score: 0.87638001, Antimicrobial agents and chemotherapy, 2001, Sadler, B M; Gillotin, C; Lou, Y; Stein, D S
Synthesis and In vitro activities of a spacer-containing glycophospholipid ligand of a lipopolysaccharide receptor involved in endotoxin tolerance
score: 0.87637803, Bioorganic & Medicinal Chemistry, 1998, Charon, Daniel et. al.
Paviosides A-H, Eight New Oleane Type Saponins from Aesculus pavia with Cytotoxic Activity
score: 0.87633169, Bioorganic & Medicinal Chemistry, 2012, Lanzotti, Virginia et. al.
Radical scavenging activities of α-alanine C 60 adduct
score: 0.87624666, Bioorganic & Medicinal Chemistry Letters, 2006, Sun, Tao; Xu, Zhude
High-Throughput Sequencing Reveals the Incomplete, Short-Term Recovery of Infant Gut Microbiota following Parenteral Antibiotic Treatment with Ampicillin and Gentamicin.
score: 0.87582477, Antimicrobial agents and chemotherapy, 2012, Fouhy, Fiona et. al.
Specific host–guest interactions in a protein-based artificial transaminase
score: 0.87580418, Bioorganic & Medicinal Chemistry, 2001, Häring, Dietmar; Distefano, Mark D
Attenuating the size and molecular carrier capabilities of polyacrylate nanoparticles by a hydrophobic fluorine effect
score: 0.87555251, Bioorganic & Medicinal Chemistry, 2012, Labruère, Raphaël; Turos, Edward
Transition state analogue inhibitors of protozoan nucleoside hydrolases
score: 0.87542036, Bioorganic & Medicinal Chemistry, 1999, Furneaux, Richard H.; Schramm, Vern L.; Tyler, Peter C.
Active efflux of norfloxacin by Bacteroides fragilis.
score: 0.87525268, Antimicrobial agents and chemotherapy, 1998, Miyamae, S; Nikaido, H; Tanaka, Y; Yoshimura, F
A QSAR study on inhibitory activities of 1-phenylbenzimidazoles against the platelet-derived growth factor receptor
score: 0.87516752, Bioorganic & Medicinal Chemistry, 2004, Zhong, Chongli; He, Jingtao; Xue, Chunyu; Li, Yajun
RNA-based diagnosis in a multicellular specimen by whole mount in situ hybridization using an RNA-specific probe
score: 0.87508908, Bioorganic & Medicinal Chemistry, 2012, Ueda, Takako et. al.
Photoactivated DNA cleavage by compounds structurally related to the bithiazole moiety of bleomycin
score: 0.87500839, Bioorganic & Medicinal Chemistry, 2001, Quada, James C.; Boturyn, Didier; Hecht, Sidney M.
Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation
score: 0.87500596, Bioorganic & Medicinal Chemistry, 1999, de Bont, Dries B.A. et. al.
No findings of dental defects in children treated with minocycline.
score: 0.87490292, Antimicrobial agents and chemotherapy, 2004, Cascio, Antonio et. al.
Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part 4: Hyperbolic Activation of Rat Liver Microsomal NADPH-Cytochrome C Reductase by the Novel Acetylator 7,8-Diacetoxy-4-methylcoumarin
score: 0.87488109, Bioorganic & Medicinal Chemistry, 1999, Raj, Hanumantharao G et. al.
Molecular probe for selective detection of thiols in water of neutral pH
score: 0.87468062, Bioorganic & Medicinal Chemistry Letters, 2003, Kim, Dong H; Su Han, Min
Nucleosides and nucleotides. Part 214: thermal stability of triplexes containing 4′α- C-Aminoalkyl-2′-deoxynucleosides
score: 0.87466363, Bioorganic & Medicinal Chemistry, 2002, Atsumi, Naoko et. al.
Identification of Human IKK-2 Inhibitors of Natural Origin (Part I): Modeling of the IKK-2 Kinase Domain, Virtual Screening and Activity Assays
score: 0.87464192, PLoS ONE, 2011, Sala, Esther et. al.
Antibacterial and antimembrane activities of cecropin A in Escherichia coli.
score: 0.87461359, Antimicrobial agents and chemotherapy, 2000, Silvestro, L; Weiser, J N; Axelsen, P H
Post-SELEX combinatorial optimization of aptamers
score: 0.87450479, Bioorganic & Medicinal Chemistry, 1997, Eaton, Bruce E. et. al.
A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A
score: 0.87423531, Bioorganic & Medicinal Chemistry, 1996, Argade, Narshinha P.; Naik, Rajan H.
Biodistribution of phosphodiester and phosphorothioate siRNA
score: 0.87417917, Bioorganic & Medicinal Chemistry Letters, 2004, Braasch, Dwaine A. et. al.
Facile synthesis of stable lipid analogues possessing a range of alkyl groups: application to artificial glycolipids
score: 0.87402205, Bioorganic & Medicinal Chemistry, 2002, Azefu, Yasuo; Tamiaki, Hitoshi; Sato, Reiko; Toma, Kazunori
Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation
score: 0.8739545, Bioorganic & Medicinal Chemistry, 2004, Kifli, Nurolaini et. al.
An oxyanion-Hole selective serine protease inhibitor in complex with trypsin
score: 0.87361991, Bioorganic & Medicinal Chemistry, 2002, Cui, Jian et. al.
In vitro activity of human beta-defensin 2 against Pseudomonas aeruginosa in the presence of tear fluid.
score: 0.87355396, Antimicrobial agents and chemotherapy, 2007, Huang, Ling C et. al.
Asymmetric aldol condensation as a route to polypropionate derived pheromones
score: 0.87350505, Bioorganic & Medicinal Chemistry, 1996, DiBattista, James P.; Webster, Francis X.
Synthesis of novel unnatural amino acid as a building block and its incorporation into an antimicrobial peptide
score: 0.87350069, Bioorganic & Medicinal Chemistry, 1999, Oh, Jong Eun; Lee, Keun Hyeung
Deciphering the function of the outer membrane protein OprD homologue of Acinetobacter baumannii.
score: 0.87334012, Antimicrobial agents and chemotherapy, 2012, Catel-Ferreira, Manuella et. al.
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS
score: 0.87317501, Frontiers in Molecular Neuroscience, 2011, Eldar-Finkelman, Hagit; Martinez, Ana
Engineering of a novel biochemical pathway for the biosynthesis of l-2-aminobutyric acid in Escherichia coli K12
score: 0.8731355, Bioorganic & Medicinal Chemistry, 1999, Fotheringham, Ian G et. al.
Molecular mechanisms of itraconazole resistance in Candida dubliniensis.
score: 0.87274781, Antimicrobial agents and chemotherapy, 2003, Pinjon, Emmanuelle et. al.
Synthesis of a novel duocarmycin derivative DU-257 and its application to immunoconjugate using poly(ethylene glycol)-dipeptidyl linker capable of tumor specific activation
score: 0.87236755, Bioorganic & Medicinal Chemistry, 2000, Suzawa, Toshiyuki et. al.
Single-dose pharmacokinetics, safety, and tolerability of albinterferon alfa-2b in subjects with end-stage renal disease on hemodialysis compared to those in matched healthy volunteers.
score: 0.87199409, Antimicrobial agents and chemotherapy, 2011, Serra, Denise B et. al.
Docking study of enantiomeric fonofos oxon bound to the active site of Torpedo californica acetylcholinesterase
score: 0.87194459, Bioorganic & Medicinal Chemistry, 2000, Hirashima, Akinori; Kuwano, Eiichi; Eto, Morifusa
Structure optimization of a leukotriene D 4 antagonist by combinatorial chemistry in solution
score: 0.87194152, Bioorganic & Medicinal Chemistry, 1997, Maehr, Hubert; Yang, Roxana
Nonconcordance with surgical site infection prevention guidelines and rates of surgical site infections for general surgical, neurological, and orthopedic procedures.
score: 0.87191942, Antimicrobial agents and chemotherapy, 2011, Young, Barnaby et. al.
Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes
score: 0.87185372, European Journal of Medicinal Chemistry, 2012, Yin, Handong et. al.
A variant peptide of buffalo colostrum β-lactoglobulin inhibits angiotensin I-converting enzyme activity
score: 0.87177573, European Journal of Medicinal Chemistry, 2012, Rohit, A.C.; Sathisha, K.; Aparna, H.S.
Diastereoisomers of an ‘arsenomethionine’-based structure from Sargassum lacerifolium: the formation of the arsenic–carbon bond in arsenic-containing natural products
score: 0.87164396, Bioorganic & Medicinal Chemistry Letters, 2000, Edmonds, John S
Systems chemical biology.
score: 0.87156788, Nature chemical biology, 2007, Oprea, Tudor I et. al.
Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents
score: 0.87135437, Bioorganic & Medicinal Chemistry, 2006, Wang, Min et. al.
An RNA aptamer that recognizes a specific conformation of the protein calsenilin
score: 0.87124956, Bioorganic & Medicinal Chemistry, 2007, Lee, Kyung Hyun et. al.
Meta-iodobenzylguanidine derivatives containing a second guanidine moiety
score: 0.87114111, Bioorganic & Medicinal Chemistry, 2004, Vaidyanathan, Ganesan et. al.
Novel vasopressin V2 receptor-selective antagonists, pyrrolo[2,1- a]quinoxaline and pyrrolo[2,1- c][1,4]benzodiazepine derivatives
score: 0.87076155, Bioorganic & Medicinal Chemistry, 1999, Ohtake, Yasuhiro et. al.
Design, development and synthesis of mixed bioconjugates of piperic acid–glycine, curcumin–glycine/alanine and curcumin–glycine–piperic acid and their antibacterial and antifungal properties
score: 0.87073271, Bioorganic & Medicinal Chemistry, 2005, Mishra, Satyendra et. al.
Photodynamic inactivation of Escherichia coli immobilized on agar surfaces by a tricationic porphyrin
score: 0.87034684, Bioorganic & Medicinal Chemistry, 2006, Caminos, Daniel A.; Durantini, Edgardo N.
Incorporation of an inducible nucleotide analog into DNA by DNA polymerases
score: 0.8703428, Bioorganic & Medicinal Chemistry, 2009, Ali, Md. Monsur et. al.
2010 Tetrahedron Young Investigator Award for Medicinal and Bioorganic Chemistry
score: 0.87031312, Bioorganic & Medicinal Chemistry, 2010, Seeberger, Peter H.
Studies of interactions between platinum(II) complexes and some biologically relevant molecules
score: 0.87004595, Bioorganic & Medicinal Chemistry, 2007, Petrović, Dejan et. al.
The hemA gene encoding glutamyl-tRNA reductase from the archaeon Methanobacterium thermoautotrophicum strain Marburg
score: 0.87001438, Bioorganic & Medicinal Chemistry, 1996, Hungerer, Christoph et. al.
Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis.
score: 0.86988054, Antimicrobial agents and chemotherapy, 2001, Patel, R; Rouse, M S; Piper, K E; Steckelberg, J M
Delay of active antimicrobial therapy and mortality among patients with bacteremia: impact of severe neutropenia.
score: 0.86975639, Antimicrobial agents and chemotherapy, 2008, Lin, Michael Y; Weinstein, Robert A; Hota, Bala
Oral lactoferrin treatment of experimental oral candidiasis in mice.
score: 0.86893909, Antimicrobial agents and chemotherapy, 2003, Takakura, Natsuko et. al.
Synthesis of 4-mercapto- l-lysine derivatives: Potential building blocks for sequential native chemical ligation
score: 0.86893615, Bioorganic & Medicinal Chemistry Letters, 2009, Pasunooti, Kalyan Kumar et. al.
Hydrazino-aza and N-azapeptoids with therapeutic potential as anticancer agents
score: 0.8688266, Bioorganic & Medicinal Chemistry, 2003, Bouget, Karine et. al.
Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A
score: 0.86882296, Bioorganic & Medicinal Chemistry, 2002, Cho, Jae Hyun et. al.
Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases.
score: 0.86880479, Antimicrobial agents and chemotherapy, 2011, Wagner, R Doug et. al.
Antimicrobial penetration and efficacy in an in vitro oral biofilm model.
score: 0.86878405, Antimicrobial agents and chemotherapy, 2011, Corbin, Audrey et. al.
Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence spectroscopy
score: 0.86866087, Bioorganic & Medicinal Chemistry, 2003, Mahara, Atsushi et. al.
Molecular dynamics simulations of the structure of aldose reductase complexed with the inhibitor tolrestat
score: 0.86855861, Bioorganic & Medicinal Chemistry Letters, 1998, Rastelli, Giulio; Costantino, Luca
Synthesis and evaluation of the antitrypanosomal and antiplasmodial activities of new 4-aminobicyclo[2.2.2]octane derivatives
score: 0.86852447, European Journal of Medicinal Chemistry, 2005, Seebacher, Werner et. al.
Porphyrin substituted phosphoramidites: new building blocks for porphyrin–oligonucleotide syntheses
score: 0.86850003, Bioorganic & Medicinal Chemistry, 2005, Balaz, Milan et. al.
Synthesis and biological activities of diflunisal hydrazide–hydrazones
score: 0.86843708, European Journal of Medicinal Chemistry, 2003, Küçükgüzel, S.Güniz et. al.
Synthesis of 4-octyl-2 H-1,4-benzo-thiazin-3-ones
score: 0.868177, European Journal of Medicinal Chemistry, 2003, Guarda, Vera L.de M. et. al.
Structure–activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum
score: 0.86815534, Bioorganic & Medicinal Chemistry, 2006, Liu, Jie et. al.
Impact of p-glycoprotein inhibition and lipopolysaccharide administration on blood-brain barrier transport of colistin in mice.
score: 0.86809488, Antimicrobial agents and chemotherapy, 2011, Jin, Liang; Li, Jian; Nation, Roger L; Nicolazzo, Joseph A
Hematologic effects of linezolid: summary of clinical experience.
score: 0.86803385, Antimicrobial agents and chemotherapy, 2002, Gerson, Stanton L et. al.
Adsorbed surfactants for affinity chromatography
score: 0.86790261, Bioorganic & Medicinal Chemistry Letters, 2003, Yaniç, Cemile et. al.
Biomimetic diels–alder cyclizations for the construction of the brevianamide, paraherquamide, sclerotamide, asperparaline and VM55599 ring systems
score: 0.86779868, Bioorganic & Medicinal Chemistry, 1998, Williams, Robert M et. al.
Molecular basis of HIV-1 TAR RNA specific recognition by an acridine tat-antagonist
score: 0.86766667, Bioorganic & Medicinal Chemistry, 1999, Gelus, Nathalie; Hamy, François; Bailly, Christian
Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases
score: 0.86755792, Chemmedchem, 2007, Brenk, Ruth et. al.
Reduction by cefodizime of the pulmonary inflammatory response induced by heat-killed Streptococcus pneumoniae in mice.
score: 0.86741592, Antimicrobial agents and chemotherapy, 1998, Bergeron, Y et. al.
SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells
score: 0.86735047, Bioorganic & Medicinal Chemistry, 2012, Galindo, José L.G. et. al.
Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis.
score: 0.8673336, Antimicrobial agents and chemotherapy, 2012, Beenken, Karen E et. al.
In vitro photo-release of a TRPV1 agonist
score: 0.8673045, Bioorganic & Medicinal Chemistry Letters, 2006, Carr, James L. et. al.
Homology model of the closed, functionally active, form of the amino terminal domain of mGluR1
score: 0.86727815, Bioorganic & Medicinal Chemistry, 2001, Costantino, Gabriele et. al.
Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities
score: 0.86722461, European Journal of Medicinal Chemistry, 2005, Julián, Miguel et. al.
Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors
score: 0.86719411, Bioorganic & Medicinal Chemistry, 2003, Xu, Yu-Wen et. al.
Potassium peroxymonosulfate (oxone) — An efficient oxidizing agent for phosphothio compounds
score: 0.86696452, Bioorganic & Medicinal Chemistry Letters, 1998, Woźniak, Lucyna A. et. al.
Synthesis, antibacterial, antifungal activity and interaction of CT-DNA with a new benzimidazole derived Cu(II) complex
score: 0.86694984, European Journal of Medicinal Chemistry, 2005, Arjmand, Farukh; Mohani, Bhawana; Ahmad, Shamim
Single-dose phase I study to evaluate the pharmacokinetics of posaconazole in new tablet and capsule formulations relative to oral suspension.
score: 0.86692927, Antimicrobial agents and chemotherapy, 2012, Krishna, Gopal; Ma, Lei; Martinho, Monika; O'Mara, Edward
99mTc-labeling of colchicine using [ 99mTc(CO) 3(H 2O) 3] + and [ 99mTc N] 2+ core for the preparation of potential tumor-targeting agents
score: 0.86692206, Bioorganic & Medicinal Chemistry, 2006, Korde, Aruna et. al.
Synthesis of sulfoquinovosylacylglycerols, inhibitors of Eukaryotic DNA Polymerase α and β
score: 0.86674811, Bioorganic & Medicinal Chemistry, 2001, Hanashima, Shinya et. al.
1,8-Naphthyridin-2,7-( 1,8H)-dione is an effective mimic of protonated cytosine in peptide nucleic acid triplex recognition systems
score: 0.86631448, Bioorganic & Medicinal Chemistry Letters, 2002, Christensen, Caspar et. al.
Can alcohol-based hand-rub solutions cause you to lose your driver's license? Comparative cutaneous absorption of various alcohols.
score: 0.86615537, Antimicrobial agents and chemotherapy, 2007, Brown, T L et. al.
Antioxidant functions required for insusceptibility of Saccharomyces cerevisiae to tetracycline antibiotics.
score: 0.86603982, Antimicrobial agents and chemotherapy, 2001, Angrave, F E; Avery, S V
Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)
score: 0.86601145, European Journal of Medicinal Chemistry, 2012, Kaluđerović, Goran N. et. al.
Pharmacokinetics of cefepime during continuous renal replacement therapy in critically ill patients.
score: 0.86593694, Antimicrobial agents and chemotherapy, 2001, Malone, R S; Fish, D N; Abraham, E; Teitelbaum, I
Chemical biologists gather in Heidelberg.
score: 0.86593135, Nature chemical biology, 2009, Köhn, Maja; Schultz, Carsten
Pharmacokinetics of posaconazole coadministered with antacid in fasting or nonfasting healthy men.
score: 0.86584037, Antimicrobial agents and chemotherapy, 2004, Courtney, Rachel et. al.
A fluorescence probe for assaying micro RNA maturation
score: 0.86572842, Bioorganic & Medicinal Chemistry, 2008, Davies, Brian P.; Arenz, Christoph
Sterilizing activities of fluoroquinolones against rifampin-tolerant populations of Mycobacterium tuberculosis.
score: 0.86567914, Antimicrobial agents and chemotherapy, 2003, Hu, Yanmin; Coates, Anthony R M; Mitchison, Denis A
Development of a bifunctional chelating agent containing isothiocyanate residue for one step F-18 labeling of peptides and application for RGD labeling
score: 0.86562046, Bioorganic & Medicinal Chemistry, 2012, Shetty, Dinesh et. al.
Nanoparticles in cellular drug delivery
score: 0.86560122, Bioorganic & Medicinal Chemistry, 2009, Faraji, Amir H.; Wipf, Peter
Chemical-genomic profiling: Systematic analysis of the cellular targets of bioactive molecules
score: 0.86559862, Bioorganic & Medicinal Chemistry, 2012, Andrusiak, Kerry; Piotrowski, Jeff S.; Boone, Charles
In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides.
score: 0.86545913, Antimicrobial agents and chemotherapy, 1998, Bergsson, G et. al.
In vitro killing of Candida albicans by fatty acids and monoglycerides.
score: 0.86545913, Antimicrobial agents and chemotherapy, 2001, Bergsson, G; Arnfinnsson, J; Steingrímsson O, ; Thormar, H
Inhibition of protein kinase C by synthetic xanthone derivatives
score: 0.86539113, Bioorganic & Medicinal Chemistry, 2003, Saraiva, Lucı́lia et. al.
Nitrite-Mediated decarboxylative conjugation of caffeic acid with glutathione under mildly acidic conditions
score: 0.86536667, Bioorganic & Medicinal Chemistry Letters, 2002, Panzella, Lucia; Napolitano, Alessandra; d'Ischia, Marco
Impairment of swimming motility by antidiarrheic Lactobacillus acidophilus strain LB retards internalization of Salmonella enterica serovar Typhimurium within human enterocyte-like cells.
score: 0.86533641, Antimicrobial agents and chemotherapy, 2011, Liévin-Le Moal, Vanessa; Amsellem, Raymonde; Servin, Alain L
Pharmacokinetics of darunavir/ritonavir and rifabutin coadministered in HIV-negative healthy volunteers.
score: 0.8652755, Antimicrobial agents and chemotherapy, 2010, Sekar, Vanitha et. al.
Pharmacokinetics of intravenous itraconazole in stable hemodialysis patients.
score: 0.86524348, Antimicrobial agents and chemotherapy, 2004, Mohr, John F et. al.
Inducible nitric oxide synthase inhibitors of Chinese herbs. Part 2: Naturally occurring furanocoumarins
score: 0.86522924, Bioorganic & Medicinal Chemistry, 2000, Wang, Ching-Chiung et. al.
Efficacies of gel formulations containing foscarnet, alone or combined with sodium lauryl sulfate, against establishment and reactivation of latent herpes simplex virus type 1.
score: 0.8651558, Antimicrobial agents and chemotherapy, 2001, Piret, J; Lamontagne, J; Désormeaux, A; Bergeron, M G
A theoretical antioxidant pharmacophore for resveratrol
score: 0.86512119, European Journal of Medicinal Chemistry, 2009, Queiroz, Auriekson N. et. al.
Seryl-histidine as an alternative DNA nicking agent in nick translation yields superior DNA probes and hybridizations
score: 0.86510614, Bioorganic & Medicinal Chemistry, 2002, Li, Yunsheng et. al.
Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
score: 0.86465067, Antimicrobial agents and chemotherapy, 2008, Pasrija, Ritu; Panwar, Sneh Lata; Prasad, Rajendra
New zirconium (IV) complexes of coumarins with cytotoxic activity
score: 0.86405821, European Journal of Medicinal Chemistry, 2006, Kostova, I.; Momekov, G.
Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes
score: 0.86403723, European Journal of Medicinal Chemistry, 2012, Yin, Handong et. al.
Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes
score: 0.86403723, European Journal of Medicinal Chemistry, 2012, Yin, Handong et. al.
Cyclic amide derivatives as potential prodrugs II: N -hydroxymethylsuccinimide- / isatin esters of some NSAIDs as prodrugs with an improved therapeutic index
score: 0.86389516, European Journal of Medicinal Chemistry, 1999, Mahfouz, Nadia M; Omar, Farghaly A; Aboul-Fadl, Tarek
A photoregulated ligand for the nuclear import receptor karyopherin α
score: 0.86370706, Bioorganic & Medicinal Chemistry, 2001, Park, Seung Bum; Standaert, Robert F.
Generation and evaluation of putative neuroregenerative drugs
score: 0.86357307, Bioorganic & Medicinal Chemistry, 2000, Adalsteinsson, Helgi; Bruice, Thomas C.
Synthesis and first in vivo evaluation of new selective high affinity β 1-adrenoceptor radioligands for SPECT based on ICI 89,406
score: 0.86350962, Bioorganic & Medicinal Chemistry, 2004, Wagner, Stefan et. al.
A solid-Supported phosphine-Free ruthenium alkylidene for olefin metathesis in methanol and water
score: 0.86337551, Bioorganic & Medicinal Chemistry Letters, 2002, Connon, Stephen J; Blechert, Siegfried
Footprinting and circular dichroism studies on paromomycin binding to the packaging region of human immunodeficiency virus type-1
score: 0.86332065, Bioorganic & Medicinal Chemistry, 2002, McPike, Mark P.; Goodisman, Jerry; Dabrowiak, James C.
Determining the mode of action of bioactive compounds
score: 0.86331777, Bioorganic & Medicinal Chemistry, 2012, Azad, Marisa A.; Wright, Gerard D.
Solid phase synthesis of structurally diverse pyrimido[4,5-d] pyrimidines for the potential use in combinatorial chemistry
score: 0.86328548, Bioorganic & Medicinal Chemistry Letters, 1999, Srivastava, Sanjay K.; Haq, W.; Chauhan, P.M.S.
The water-soluble fullerene derivative ‘Radical Sponge ®’ exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes
score: 0.8632408, Bioorganic & Medicinal Chemistry Letters, 2006, Xiao, Li; Takada, Hiroya; Gan, Xue hui; Miwa, Nobuhiko
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
score: 0.86323139, Bioorganic & Medicinal Chemistry, 2012, Su, Xiangdong et. al.
Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures.
score: 0.86308373, Antimicrobial agents and chemotherapy, 2001, McDonald, L C et. al.
Beta-lactamase-producing nontypeable Haemophilus influenzae fails to protect Streptococcus pneumoniae from amoxicillin during experimental acute otitis media.
score: 0.86286576, Antimicrobial agents and chemotherapy, 2004, Westman, Eva; Lundin, Susanne; Hermansson, Ann; Melhus, Asa
Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae)
score: 0.86266427, Bioorganic & Medicinal Chemistry, 1996, González, Antonio G. et. al.
UV-B protective effect of a polyacylated anthocyanin, HBA, in flower petals of the blue morning glory, Ipomoea tricolor cv. Heavenly Blue
score: 0.86266163, Bioorganic & Medicinal Chemistry, 2005, Mori, Mihoko et. al.
A dose ranging study of the pharmacokinetics, safety, and preliminary efficacy of lamivudine in children and adolescents with chronic hepatitis B.
score: 0.86246325, Antimicrobial agents and chemotherapy, 2000, Sokal, E M et. al.
Spirostanols obtained by cyclization of pseudosaponin derivatives and comparison of anti-platelet agglutination activities of spirostanol glycosides
score: 0.86245651, European Journal of Medicinal Chemistry, 2000, Tobari, Akihiko et. al.
Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3 H-benz[ e]indole ( seco-CBI) dimers
score: 0.86233461, Bioorganic & Medicinal Chemistry, 2000, Jia, Guofeng; Lown, J.William
Antioxidant activity of differently regioselective chitosan sulfates in vitro
score: 0.86206401, Bioorganic & Medicinal Chemistry, 2005, Xing, Ronge et. al.
Differences in the lipoprotein distribution of free and liposome-associated all-trans-retinoic acid in human, dog, and rat plasma are due to variations in lipoprotein lipid and protein content.
score: 0.86187657, Antimicrobial agents and chemotherapy, 1998, Wasan, K M et. al.
A novel neoglycopeptide building block
score: 0.86158685, Bioorganic & Medicinal Chemistry, 2003, Bartolozzi, Alessandra; Li, Baoqing; Franck, Richard W
Inhibition of human β-tryptase by Bowman–Birk inhibitor derived peptides: creation of a new tri-functional inhibitor
score: 0.86135002, Bioorganic & Medicinal Chemistry, 2004, Scarpi, Dina; McBride, Jeffrey D.; Leatherbarrow, Robin J.
Cell-penetration by Co(III)cyclen-based peptide-cleaving catalysts selective for pathogenic proteins of amyloidoses
score: 0.86104084, Bioorganic & Medicinal Chemistry, 2010, Chei, Woo Suk; Lee, Joo-Won; Kim, Jae Bum; Suh, Junghun
Synthesis of the palmitoylated and prenylated C-terminal lipopeptides of the human R- and N- Ras proteins
score: 0.86099964, Bioorganic & Medicinal Chemistry, 1999, Schmittberger, T.; Waldmann, H.
Antiestrogenic and antigenotoxic activity of bee pollen from Cystus incanus and Salix alba as evaluated by the yeast estrogen screen and the micronucleus assay in human lymphocytes
score: 0.86096878, European Journal of Medicinal Chemistry, 2010, Pinto, Barbara et. al.
Posaconazole as salvage therapy for zygomycosis.
score: 0.86073716, Antimicrobial agents and chemotherapy, 2006, Greenberg, R N et. al.
High-frequency, in vitro reversible switching of Candida lusitaniae clinical isolates from amphotericin B susceptibility to resistance.
score: 0.86060692, Antimicrobial agents and chemotherapy, 1999, Yoon, S A et. al.
Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cr (III), Mn (III) and Fe (III) macrocyclic complexes
score: 0.86048665, European Journal of Medicinal Chemistry, 2012, Kumar, Gajendra et. al.
Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cr (III), Mn (III) and Fe (III) macrocyclic complexes
score: 0.86048665, European Journal of Medicinal Chemistry, 2012, Kumar, Gajendra et. al.
Artemether and artesunate show the highest efficacies in rescuing mice with late-stage cerebral malaria and rapidly decrease leukocyte accumulation in the brain.
score: 0.86026995, Antimicrobial agents and chemotherapy, 2011, Clemmer, L et. al.
Identification and validation of bioactive small molecule target through phenotypic screening
score: 0.86018667, Bioorganic & Medicinal Chemistry, 2012, Cho, Yoon Sun; Kwon, Ho Jeong
Synthesis and deconvolution of the first combinatorial library of glycosidase inhibitors
score: 0.860049, Bioorganic & Medicinal Chemistry, 1999, Lohse, Anders et. al.
Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America.
score: 0.85976922, Antimicrobial agents and chemotherapy, 2007, McCollum, Andrea M et. al.
Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms.
score: 0.85960895, Antimicrobial agents and chemotherapy, 2001, Ramage, G; Vande Walle, K; Wickes, B L; López-Ribot, J L
Synthesis and characterization of Bis(μ-hydroxo)diiron(III) complex of N-(4-Nitro-2-hydroxy)phenylmethyl- N-(2-pyridylethyl)- N-(2-pyridylmethyl)amine and hydroxylation reaction of alkane
score: 0.85956272, Bioorganic & Medicinal Chemistry Letters, 2001, Kurosaki, Hiromasa et. al.
New antineoplastic prenylhydroquinones. Synthesis and evaluation
score: 0.85945519, Bioorganic & Medicinal Chemistry, 2000, Molinari, Aurora et. al.
Effects of escins Ia, Ib, IIa, and IIb from horse chestnuts on gastrointestinal transit and ileus in mice
score: 0.85940726, Bioorganic & Medicinal Chemistry, 1999, Matsuda, Hisashi; Li, Yuhao; Yoshikawa, Masayuki
Antioxidative constituents in Heterotheca inuloides
score: 0.85921614, Bioorganic & Medicinal Chemistry, 1997, Haraguchi, Hiroyuki et. al.
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate
score: 0.85903075, Bioorganic & Medicinal Chemistry, 2005, Kiuchi, Masatoshi et. al.
Pyrene-modified guanosine as fluorescent probe for DNA modulated by charge transfer
score: 0.85888045, Bioorganic & Medicinal Chemistry, 2008, Wanninger-Weiß, Claudia et. al.
TRH mimetics: Differentiation of antiamnesic potency from antidepressant effect
score: 0.85886944, Bioorganic & Medicinal Chemistry, 1997, Mazurov, Anatoly A. et. al.
Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.
score: 0.85884527, Antimicrobial agents and chemotherapy, 2005, Wan, William B et. al.
Antibacterial mechanism of action of arylamide foldamers.
score: 0.8588331, Antimicrobial agents and chemotherapy, 2011, Mensa, Bruk et. al.
Design and application of a peptide nucleic acid sequence targeting the p75 neurotrophin receptor
score: 0.85879346, Bioorganic & Medicinal Chemistry Letters, 2003, Cheah, Irwin K. et. al.
Purification and characterization of an alkaline lipase from a newly isolated Pseudomonas mendocina PK-12CS and chemoselective hydrolysis of fatty acid ester † † CDRI Communication No. 6212.
score: 0.85875104, Bioorganic & Medicinal Chemistry, 2003, Jinwal, Umesh K et. al.
Directed evolution of an esterase: screening of enzyme libraries based on ph-Indicators and a growth assay
score: 0.85868703, Bioorganic & Medicinal Chemistry, 1999, Bornscheuer, Uwe T.; Altenbuchner, Josef; Meyer, Hartmut H.
Microbiological aetiology, epidemiology, and clinical profile of prosthetic joint infections: are current antibiotic prophylaxis guidelines effective?
score: 0.8585755, Antimicrobial agents and chemotherapy, 2012, Peel, Trisha N et. al.
Unprecedented olefin-dependent histidine–kinase inhibitory of zerumbone ring-opening material
score: 0.8583985, Bioorganic & Medicinal Chemistry Letters, 2004, Kitayama, Takashi et. al.
QSPR/QSAR in N-[(dimethylamine)methyl] benzamides substituents groups influence upon electronic distribution and local anesthetics activity
score: 0.85826811, Bioorganic & Medicinal Chemistry, 2004, Tavares, Leoberto Costa; do Amaral, Antonia Tavares
Molecular structure and stability of perindopril erbumine and perindopril l-arginine complexes
score: 0.85812158, European Journal of Medicinal Chemistry, 2009, Remko, Milan
Efficient synthesis of 5′- O-laurate of 1-β- d-arabinofuranosylcytosine via highly regioselective enzymatic acylation in binary solvent mixtures
score: 0.85803678, Bioorganic & Medicinal Chemistry Letters, 2010, Li, Xiao-feng; Zong, Min-hua; Zhao, Guang-lei
Synthesis, conformation, and immunogenicity of monosaccharide-centered multivalent HIV-1 gp41 peptides containing the sequence of DP178
score: 0.8578969, Bioorganic & Medicinal Chemistry, 2004, Ni, Jiahong et. al.
The binding of 3′- N-piperidine-4-carboxyl-3′-deoxy- ara-uridine to ribonuclease A in the crystal
score: 0.85786558, Bioorganic & Medicinal Chemistry, 2006, Leonidas, Demetres D. et. al.
Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase
score: 0.85773195, Bioorganic & Medicinal Chemistry, 2006, Mbadugha, Bessie N.A. et. al.
α-Lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers
score: 0.8574236, Bioorganic & Medicinal Chemistry, 2001, Wang, Harry C; Kurimoto, Miki; Kahr, Bart; Chmielewski, Jean
Analysis of datasets showing which compounds kill which organisms: inferring two systems
score: 0.85739859, European Journal of Medicinal Chemistry, 2004, Hutchinson, T.P.
Solution conformations of two naturally occurring RNA nucleosides: 3-Methyluridine and 3-methylpseudouridine
score: 0.85734264, Bioorganic & Medicinal Chemistry, 2005, Desaulniers, Jean-Paul et. al.
Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding
score: 0.85734051, Bioorganic & Medicinal Chemistry, 2006, Liu, Yan et. al.
Probing the conformation of bilirubins with monopropionic analogs: a biological, spectroscopic, and molecular modeling study
score: 0.85731211, Bioorganic & Medicinal Chemistry, 1998, Kogan, Marcelo J. et. al.
New 1α,25-dihydroxy vitamin D 3 analogues with side chains attached to C-18: synthesis and biological activity
score: 0.85727726, Bioorganic & Medicinal Chemistry, 1998, Grue-Sørensen, Gunnar; Hansen, Christina Mørk
Rapid genotyping of CTX-M extended-spectrum beta-lactamases by denaturing high-performance liquid chromatography.
score: 0.85725195, Antimicrobial agents and chemotherapy, 2007, Xu, Li et. al.
Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages
score: 0.85719726, Bioorganic & Medicinal Chemistry Letters, 2002, Dubowchik, Gene M et. al.
Metabolism of 5′α,8′-cycloabscisic acid, a highly potent and long-lasting abscisic acid analogue, in radish seedlings
score: 0.85664875, Bioorganic & Medicinal Chemistry, 2004, Todoroki, Yasushi et. al.
Improved detection of mutated human cytomegalovirus UL97 by pyrosequencing.
score: 0.85662366, Antimicrobial agents and chemotherapy, 2010, Schindele, Birgit et. al.
Cytochrome P-450 model reactions: Efficient and highly selective oxidation of alcohols with tetrabutylammonium peroxymonosulfate catalyzed by Mn-porphyrins
score: 0.85646745, Bioorganic & Medicinal Chemistry, 2007, Rezaeifard, Abdolreza et. al.
Convenient method for the addition of disulfides to alkenes
score: 0.8564349, Bioorganic & Medicinal Chemistry Letters, 2007, Yamagiwa, Noriyuki; Suto, Yutaka; Torisawa, Yasuhiro
Synthesis of a new series of heterocyclic scaffolds for medicinal purposes
score: 0.85622364, European Journal of Medicinal Chemistry, 2006, Hilal, H.S. et. al.
ORL1 and opioid receptor preferences of nociceptin and dynorphin A analogues with Dmp substituted for N-terminal aromatic residues
score: 0.85620963, Bioorganic & Medicinal Chemistry, 2006, Sasaki, Yusuke et. al.
Mucoadhesive microspheres containing amoxicillin for clearance of Helicobacter pylori.
score: 0.85609654, Antimicrobial agents and chemotherapy, 1998, Nagahara, N et. al.
Synthesis and in vivo analgesic and anti-inflammatory activity of some bi heterocyclic coumarin derivatives
score: 0.85601841, European Journal of Medicinal Chemistry, 2005, Ghate, Manjunath; Kusanur, R.A.; Kulkarni, M.V.
Effects of bicyclomycin on RNA- and ATP-binding activities of transcription termination factor Rho.
score: 0.85598054, Antimicrobial agents and chemotherapy, 1998, Carrano, L et. al.
Equol, a natural estrogenic metabolite from soy isoflavones
score: 0.85552871, Bioorganic & Medicinal Chemistry, 2004, Muthyala, Rajeev S et. al.
Effects of renal function on pharmacokinetics of recombinant human granulocyte colony-stimulating factor in lung cancer patients.
score: 0.85539034, Antimicrobial agents and chemotherapy, 2001, Fukuda, M et. al.
Synthesis of novel 4- and 5-substituted benzyl ether derivatives of vesamicol and in vitro evaluation of their binding properties to the vesicular acetylcholine transporter site
score: 0.8553864, Bioorganic & Medicinal Chemistry, 2004, Scheunemann, Matthias et. al.
An efficient approach to the asymmetric total synthesis of (–)-anisodine
score: 0.85519033, European Journal of Medicinal Chemistry, 2006, Chang, Junbiao et. al.
Open-label, randomized comparison of itraconazole versus caspofungin for prophylaxis in patients with hematologic malignancies.
score: 0.8551764, Antimicrobial agents and chemotherapy, 2006, Mattiuzzi, Gloria N et. al.
Intrapulmonary distribution and pharmacokinetics of laninamivir, a neuraminidase inhibitor, after a single inhaled administration of its prodrug, laninamivir octanoate, in healthy volunteers.
score: 0.85509064, Antimicrobial agents and chemotherapy, 2012, Ishizuka, Hitoshi et. al.
Kinamycin acetyltransferase I from Streptomyces murayamaensis, an apparently large, membrane-associated enzyme
score: 0.85498643, Bioorganic & Medicinal Chemistry, 1996, Gould, Steven J et. al.
Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants.
score: 0.85490173, Antimicrobial agents and chemotherapy, 2005, Capparelli, Edmund V et. al.
Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: A correlation?
score: 0.85489512, Bioorganic & Medicinal Chemistry, 2012, Böttger, Stefan; Hofmann, Katja; Melzig, Matthias F.
Reactions of hydroxyl radical with bergenin, a natural poly phenol studied by pulse radiolysis
score: 0.85473548, Bioorganic & Medicinal Chemistry, 2009, Singh, Umang; Barik, Atanu; Priyadarsini, K. Indira
Pharmacokinetics and metabolism of [(14)C]ribavirin in rats and cynomolgus monkeys.
score: 0.8546039, Antimicrobial agents and chemotherapy, 2003, Lin, Chin-Chung et. al.
Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines as inhibitors of TNF-α and IL-6
score: 0.85440116, European Journal of Medicinal Chemistry, 2012, Guirado, Antonio et. al.
Interactions between 1-benzoyl-4- p-chlorophenyl thiosemicarbazide and serum albumin: investigation by fluorescence spectroscopy
score: 0.85406892, Bioorganic & Medicinal Chemistry, 2004, Cui, Feng-Ling; Fan, Jing; Li, Jian-Ping; Hu, Zhi-De
The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides
score: 0.85399326, Bioorganic & Medicinal Chemistry, 2009, Sannohe, Yuta et. al.
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein
score: 0.85398699, Nature Chemical Biology, 2011, Woods, Lucy A. et. al.
Backtranslating clinical knowledge for use in cheminformatics—What is the potential?
score: 0.85398448, Bioorganic & Medicinal Chemistry, 2012, Scheiber, Josef
Backtranslating clinical knowledge for use in cheminformatics—What is the potential?
score: 0.85398448, Bioorganic & Medicinal Chemistry, 2012, Scheiber, Josef
Theoretical analysis of the retention behavior of alcohols in gas chromatography
score: 0.85398379, Bioorganic & Medicinal Chemistry, 2005, Song, Yuanzhi et. al.
Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers.
score: 0.85394548, Antimicrobial agents and chemotherapy, 2003, Geller, B L et. al.
Novel Irreversible Butyrylcholinesterase Inhibitors: 2-Chloro-1-(substituted-phenyl)ethylphosphonic Acids
score: 0.85384548, Bioorganic & Medicinal Chemistry, 2002, Zhang, Nanjing; Casida, John E
The Structural Determinants of Macrolide-Actin Binding: In Silico Insights
score: 0.85380016, Biophysical Journal, 2007, Melville, James L. et. al.
Effect of chemical modifications of cytosine and guanine in a cpg-motif of oligonucleotides: structure–immunostimulatory activity relationships
score: 0.85367898, Bioorganic & Medicinal Chemistry, 2001, Kandimalla, Ekambar R et. al.
Radiolabeling of RGD peptide and preliminary biological evaluation in mice bearing U87MG tumors
score: 0.85359956, Bioorganic & Medicinal Chemistry, 2012, Li, Jianbo et. al.
Cocaine pharmacology and current pharmacotherapies for its abuse
score: 0.85358921, Bioorganic & Medicinal Chemistry, 2004, Carrera, M.Rocı́o A.; Meijler, Michael M.; Janda, Kim D.
Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations.
score: 0.85353525, Antimicrobial agents and chemotherapy, 2001, Wang, H; Dzink-Fox, J L; Chen, M; Levy, S B
Synthesis of some novel imidazolinones as potent anticonvulsant agents
score: 0.85348041, European Journal of Medicinal Chemistry, 2003, Joshi, Hashmukh; Upadhyay, Paresh; Karia, Denish; Baxi, A.J
A ‘Retro–Inverso’ PNA: structural implications for DNA and RNA binding
score: 0.85340258, Bioorganic & Medicinal Chemistry, 1998, Krotz, Achim H. et. al.
Ligand recognition in μ opioid receptor: experimentally based modeling of μ opioid receptor binding sites and their testing by ligand docking
score: 0.85338111, Bioorganic & Medicinal Chemistry, 1996, Sagara, Takeshi et. al.
Acceptor hydroxyl group mapping for human milk α1–3 and α1-3/4 fucosyltransferases
score: 0.85336459, Bioorganic & Medicinal Chemistry, 1996, Gosselin, Sylvie; Palcic, Monica M.
Solution chemistry and cytotoxic properties of novel organogold(III) compounds
score: 0.85335987, Bioorganic & Medicinal Chemistry, 2004, Messori, Luigi et. al.
Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives
score: 0.852817, Bioorganic & Medicinal Chemistry, 2002, Saraiva, Lucı́lia et. al.
Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.
score: 0.85258273, Antimicrobial agents and chemotherapy, 2011, James, Scott H et. al.
Square pyramidal copper(II) complexes with forth generation fluoroquinolone and neutral bidentate ligand: Structure, antibacterial, SOD mimic and DNA-interaction studies
score: 0.85251497, Bioorganic & Medicinal Chemistry, 2010, Patel, Mohan N.; Parmar, Pradhuman A.; Gandhi, Deepen S.
A structure–taste study of arylsulfonyl(cyclo)alkanecarboxylic acids
score: 0.85237297, Bioorganic & Medicinal Chemistry, 2005, Lysiak, Violetta et. al.
Transcription and reverse transcription of artificial nucleic acids involving backbone modification by template-directed DNA polymerase reactions
score: 0.85236635, Bioorganic & Medicinal Chemistry, 2009, Kuwahara, Masayasu et. al.
Site-specific covalent labeling of proteins inside live cells using small molecule probes
score: 0.85236246, Bioorganic & Medicinal Chemistry, 2009, Chattopadhaya, Souvik et. al.
Sequence-specific delivery of a quinone methide intermediate to the major groove of DNA
score: 0.85194664, Bioorganic & Medicinal Chemistry, 2001, Zhou, Qibing et. al.
Prospects for new antimicrobials based on N,N-dimethylbiguanide complexes as effective agents on both planktonic and adhered microbial strains
score: 0.85179914, European Journal of Medicinal Chemistry, 2010, Olar, Rodica et. al.
Prospects for new antimicrobials based on N,N-dimethylbiguanide complexes as effective agents on both planktonic and adhered microbial strains
score: 0.85179914, European Journal of Medicinal Chemistry, 2010, Olar, Rodica et. al.
Synthesis and preliminary biological characterization of a new potential 125I-Radioligand for dopamine and serotonin receptors
score: 0.85176414, Bioorganic & Medicinal Chemistry, 2001, Guarna, Antonio et. al.
Synthesis and antimicrobial activity of squalamine analogue
score: 0.85164128, Bioorganic & Medicinal Chemistry, 2000, Kim, Hong-Seok et. al.
Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.
score: 0.85143788, Antimicrobial agents and chemotherapy, 2006, Malakhov, Michael P et. al.
Therapeutic efficacy of "nubiotics" against burn wound infection by Pseudomonas aeruginosa.
score: 0.85140136, Antimicrobial agents and chemotherapy, 2004, Dale, Roderic M K; Schnell, Glen; Wong, Jonathan P
Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)
score: 0.85123054, Bioorganic & Medicinal Chemistry Letters, 2002, Kotandeniya, Delshanee; Ganley, Brian; Gates, Kent S.
Fluorescence property of oxazole yellow-linked oligonucleotide. Triple helix formation and photocleavage of double-stranded DNA in the presence of spermine
score: 0.85120922, Bioorganic & Medicinal Chemistry, 1999, Inoue, Teruhiko et. al.
Retraction notice to “Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: Synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats” [Bioorg. Med. Chem. 17 (2007) 15 (2007) 4903–4909]
score: 0.85116888, Bioorganic & Medicinal Chemistry, 2009, Dhaneshwar, Suneela S. et. al.
Selective protein modification by the hydroperoxide intermediate in a photoprotein, aequorin
score: 0.85096919, Bioorganic & Medicinal Chemistry, 2009, Doi, Issei; Kuse, Masaki; Nishikawa, Toshio; Isobe, Minoru
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.
score: 0.85091275, Nature chemical biology, 2010, Stewart, Michelle L et. al.
Generation and evaluation of putative neuroregenerative drugs
score: 0.85062154, Bioorganic & Medicinal Chemistry, 2000, Adalsteinsson, Helgi; Bruice, Thomas C.
Heteroarylisopropylamines as MAO inhibitors
score: 0.8504789, Bioorganic & Medicinal Chemistry, 2005, Vallejos, Gabriel et. al.
Regioselective nitration of N α, N 1-bis(trifluoroacetyl)- l-tryptophan methyl ester: Efficient synthesis of 2-nitro and 6-nitro- N-trifluoroacetyl- l-tryptophan methyl ester
score: 0.85036331, Bioorganic & Medicinal Chemistry Letters, 2008, Osborne, Andrew S. et. al.
A quantum chemical and statistical study of ganoderic acids with cytotoxicity against tumor cell
score: 0.85034843, European Journal of Medicinal Chemistry, 2005, Yang, Hai-long; Chen, Gao-hong; Li, Yan-qun
Resolution of ( RS)-Proglumide using Lipase from Candida cylindraceae
score: 0.85001271, Bioorganic & Medicinal Chemistry, 2002, Muralidhar, R.V et. al.
Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors
score: 0.84990826, Bioorganic & Medicinal Chemistry, 1997, Kerdesky, Francis A.J. et. al.
Pilot randomized double-blind trial of treatment of Mycobacterium ulcerans disease (Buruli ulcer) with topical nitrogen oxides.
score: 0.84975224, Antimicrobial agents and chemotherapy, 2004, Phillips, R et. al.
Quality assurance program for clinical measurement of antiretrovirals: AIDS clinical trials group proficiency testing program for pediatric and adult pharmacology laboratories.
score: 0.84964479, Antimicrobial agents and chemotherapy, 2004, Holland, Diane T et. al.
An Unusually Cold Active Nitroreductase for Prodrug Activations
score: 0.84953658, Bioorganic & Medicinal Chemistry, 2012, Çelik, Ayhan; Yetiş, Gülden
Symmetry-based inhibitors of HIV-1 protease. Design, synthesis and preliminary structure-activity studies of acylated 2,3-diamino-1-hydroxypropanes and 2,4 diamino-1-hydroxybutanes
score: 0.84943465, European Journal of Medicinal Chemistry, 1999, Marastoni, Mauro et. al.
Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4.
score: 0.8492398, Nature chemical biology, 2011, Hothorn, Michael; Dabi, Tsegaye; Chory, Joanne
Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus.
score: 0.84886183, Antimicrobial agents and chemotherapy, 2012, Zhao, Yanan et. al.
A new polyamine derivative, a structural analog of spermine, with in vivo activity as an inhibitor of ethanol appetite
score: 0.84881064, Bioorganic & Medicinal Chemistry, 2005, Font, María et. al.
In vivo monitoring of alkaloid metabolism in hybrid plant cell cultures by 2D cryo-NMR without labelling
score: 0.84879443, Bioorganic & Medicinal Chemistry, 2003, Hinse, Christiane et. al.
The aphid sex pheromone cyclopentanoids: Synthesis in the elucidation of structure and biosynthetic pathways
score: 0.84871208, Bioorganic & Medicinal Chemistry, 1996, Dawson, Glenn W.; Pickett, John A.; Smiley, Diane W.M.
Improving the membrane permeability of sialic acid derivatives
score: 0.84870018, Bioorganic & Medicinal Chemistry, 2006, Altamore, Timothy M.; Duggan, Peter J.; Krippner, Guy Y.
Clarifying the structure of granadaene: Total synthesis of related analogue [2]-granadaene and confirmation of its absolute stereochemistry
score: 0.84866388, Bioorganic & Medicinal Chemistry, 2012, Paradas, Miguel et. al.
Clarifying the structure of granadaene: Total synthesis of related analogue [2]-granadaene and confirmation of its absolute stereochemistry
score: 0.84866388, Bioorganic & Medicinal Chemistry, 2012, Paradas, Miguel et. al.
Clarifying the structure of granadaene: Total synthesis of related analogue [2]-granadaene and confirmation of its absolute stereochemistry
score: 0.84866388, Bioorganic & Medicinal Chemistry, 2012, Paradas, Miguel et. al.
Dolichylpyrophosphate oligosaccharides: large-scale isolation and evaluation as oligosaccharyltransferase substrates
score: 0.84865942, Bioorganic & Medicinal Chemistry, 1999, Gibbs, Barbara S; Coward, James K
Recent advances in tumor-targeting anticancer drug conjugates
score: 0.84850099, Bioorganic & Medicinal Chemistry, 2005, Jaracz, Stanislav et. al.
Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model.
score: 0.84830299, Antimicrobial agents and chemotherapy, 2010, Olakanmi, Oyebode et. al.
Design and synthesis of chiral and racemic phosphonate-based haptens for the induction of aldolase catalytic antibodies
score: 0.84812163, Bioorganic & Medicinal Chemistry, 1997, Mu, YongQi; Gibbs, Richard A
The antioxidant activity of glucosamine hydrochloride in vitro
score: 0.84803334, Bioorganic & Medicinal Chemistry, 2006, Xing, Ronge et. al.
Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase
score: 0.84792438, Bioorganic & Medicinal Chemistry, 2003, Goodyer, Claire L.M. et. al.
Synthesis and characterization of a catalytic Antibody–HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation
score: 0.847903, Bioorganic & Medicinal Chemistry, 2002, Satchi-Fainaro, Ronit et. al.
Tipranavir-ritonavir genotypic resistance score in protease inhibitor-experienced patients.
score: 0.84789046, Antimicrobial agents and chemotherapy, 2008, Marcelin, Anne-Genevieve et. al.
Synthesis, characterization and cytotoxicity of ammine/ethylamine platinum(II) complexes with carboxylates
score: 0.84758847, European Journal of Medicinal Chemistry, 2009, Zhang, Jinchao; Li, Yaping; Sun, Jing
Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines
score: 0.84754274, Bioorganic & Medicinal Chemistry, 1996, Kawamura, Akira et. al.
Mucoadjuvant properties of lipo- and glycoconjugated derivatives of oligochitosans
score: 0.8475276, European Journal of Medicinal Chemistry, 2009, Svirshchevskaya, E.V. et. al.
Conformationally restricted PACAP27 analogues incorporating type II/II′ IBTM β-Turn Mimetics. Synthesis, NMR Structure Determination, and Binding Affinity
score: 0.84740352, Bioorganic & Medicinal Chemistry, 2001, González-Muñiz, Rosario et. al.
Synthesis of carbohydrate-conjugate heterobimetallic Cu II–Sn 2 IV and Zn II–Sn 2 IV complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity
score: 0.84737731, European Journal of Medicinal Chemistry, 2010, Tabassum, Sartaj et. al.
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.
score: 0.84716793, Nature chemical biology, 2011, Reaper, Philip M et. al.
Challenges facing the biologist doing chemical genetics.
score: 0.84714046, Nature chemical biology, 2006, Soderholm, Jon et. al.
Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.
score: 0.84713126, Antimicrobial agents and chemotherapy, 2004, Vollmer, Jörg et. al.
Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents
score: 0.84709767, Bioorganic & Medicinal Chemistry, 2012, Romeo, Roberto et. al.
Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents
score: 0.84709767, Bioorganic & Medicinal Chemistry, 2012, Romeo, Roberto et. al.
Synthesis of oligonucleotides containing a new azobenzene fragment with efficient photoisomerizability
score: 0.8470654, Bioorganic & Medicinal Chemistry, 1999, Yamana, Kazushige; Kan, Katsushi; Nakano, Hidehiko
The genes degQ, pps, and lpa-8 (sfp) are responsible for conversion of Bacillus subtilis 168 to plipastatin production.
score: 0.84691859, Antimicrobial agents and chemotherapy, 1999, Tsuge, K; Ano, T; Hirai, M; Nakamura, Y; Shoda, M
In vivo screening of haloalkane dehalogenase mutants
score: 0.8468495, Bioorganic & Medicinal Chemistry, 1999, Chang, Chia-Hwa et. al.
Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine
score: 0.84661661, European Journal of Medicinal Chemistry, 2002, Matosiuk, Dariusz et. al.
Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin
score: 0.84644042, European Journal of Medicinal Chemistry, 2003, Kieć-Kononowicz, Katarzyna et. al.
Anti-MRSA cephems. Part 3
score: 0.84643906, Bioorganic & Medicinal Chemistry, 2003, Springer, Dane M et. al.
Microbial transformation of 2-hydroxy and 2-acetoxy ketones with Geotrichum sp.
score: 0.84638304, Bioorganic & Medicinal Chemistry, 2000, Wei, Zhi-Liang; Lin, Guo-Qiang; Li, Zu-Yi
Synthesis and evaluation of new phosphonolipid compounds for gene delivery
score: 0.8461531, European Journal of Medicinal Chemistry, 2008, Dal-Maso, Angélique Durand et. al.
Pharmacokinetics of indinavir and nelfinavir in treatment-naive, human immunodeficiency virus-infected subjects.
score: 0.84597508, Antimicrobial agents and chemotherapy, 2004, DiCenzo, Robert et. al.
NFκB decoy delivery using dendritic poly( l-lysine) for treatment of endotoxin-induced hepatitis in mice
score: 0.84588884, Bioorganic & Medicinal Chemistry, 2009, Sugao, Yusuke et. al.
Biological Properties of N-Acyl and N-Haloacetyl Neuraminic Acids: Processing by Enzymes of Sialic Acid Metabolism, and Interaction with Influenza Virus
score: 0.84585954, Bioorganic & Medicinal Chemistry, 2002, Humphrey, Andrew J et. al.
Pharmacologic characteristics of indinavir, didanosine, and stavudine in human immunodeficiency virus-infected children receiving combination therapy.
score: 0.8458481, Antimicrobial agents and chemotherapy, 2000, Fletcher, C V et. al.
Chemical synthesis, structural analysis, and decomposition of N-nitroso bile acid conjugates
score: 0.84580092, Bioorganic & Medicinal Chemistry, 1996, Dayal, Bishambar et. al.
Copper(II) complexes with N, N′-dialkyl-1,10-phenanthroline–2,9-dimethanamine: synthesis, characterization, DNA-binding thermodynamical and kinetic studies
score: 0.84568958, Bioorganic & Medicinal Chemistry, 2001, Wang, Zhong-Ming et. al.
Acyclovir, ganciclovir, and zidovudine transfer into rat milk.
score: 0.84568478, Antimicrobial agents and chemotherapy, 2002, Alcorn, Jane; McNamara, Patrick J
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells
score: 0.84563745, Bioorganic & Medicinal Chemistry, 2005, Matsumoto, Kenji et. al.
Preparation of synthetic polyoxazoline based carrier and Vibrio cholerae O-specific polysaccharide conjugate vaccine
score: 0.84559021, European Journal of Medicinal Chemistry, 2010, Farkaš, Pavol et. al.
Modest but variable effect of rifampin on steady-state plasma pharmacokinetics of efavirenz in healthy African-American and Caucasian volunteers.
score: 0.84540251, Antimicrobial agents and chemotherapy, 2011, Kwara, Awewura et. al.
Structure-based design of parasitic protease inhibitors
score: 0.84531326, Bioorganic & Medicinal Chemistry, 1996, Li, Rongshi et. al.
A variant peptide of buffalo colostrum β-lactoglobulin inhibits angiotensin I converting enzyme activity
score: 0.84530078, European Journal of Medicinal Chemistry, 2012, Rohit, A.C.; Sathisha, K.; Aparna, H.S.
Molecular recognition by Kluyveromyces of amphotericin B-loaded, galactose-tagged, poly (lactic acid) microspheres
score: 0.84521958, Bioorganic & Medicinal Chemistry, 2002, Kassab, Rima et. al.
Aponeocarzinostatin—A superior drug carrier exhibiting unusually high endurance against denaturants
score: 0.8452037, Bioorganic & Medicinal Chemistry, 2006, Sudhahar, Christopher G.; Chin, Der-Hang
Inclusion complexes of pyrimethamine in 2-hydroxypropyl-β-cyclodextrin: Characterization, phase solubility and molecular modelling
score: 0.84517929, Bioorganic & Medicinal Chemistry, 2007, de Araújo, Márcia Valéria Gaspar et. al.
Tipranavir (TPV) genotypic inhibitory quotient predicts virological response at 48 weeks to TPV-based salvage regimens.
score: 0.84495781, Antimicrobial agents and chemotherapy, 2008, de Requena, Daniel Gonzalez et. al.
Synthesis, nanosizing and in vitro drug release of a novel anti-HIV polymeric prodrug: Chitosan- O-isopropyl-5′- O-d4T monophosphate conjugate
score: 0.84487784, Bioorganic & Medicinal Chemistry, 2010, Yang, Lin et. al.
Synthesis of new steroidal isoxazoles: inhibitors of estrogen synthase
score: 0.84483016, Bioorganic & Medicinal Chemistry, 1998, Li, Shengrong et. al.
Quantitative structure–Activity relationships of phenolic compounds causing apoptosis
score: 0.84471349, Bioorganic & Medicinal Chemistry, 2003, Hansch, Corwin et. al.
Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal β-vinyl-substituted phosphotyrosyl mimetic
score: 0.84450048, Bioorganic & Medicinal Chemistry, 2005, Oishi, Shinya et. al.
Safety and efficacy of multilamellar liposomal nystatin against disseminated candidiasis in persistently neutropenic rabbits.
score: 0.8444397, Antimicrobial agents and chemotherapy, 1999, Groll, A H et. al.
Isolation and characterization of enantioselective DNA aptamers for ibuprofen
score: 0.84424124, Bioorganic & Medicinal Chemistry, 2010, Kim, Yeon Seok; Hyun, Chang Jun; Kim, In Ae; Gu, Man Bock
Total synthesis and conformational studies of hapalosin, N-desmethylhapalosin and 8-Deoxyhapalosin 1 Dedicated with affection and respect to the memory of Professor Sir Derek H. R. Barton in recognition of his distinguished contributions to science and in sincere gratitude for the immense degree of inspiration and encouragement he provided to one of us (J. Zhu). 1
score: 0.84417037, Bioorganic & Medicinal Chemistry, 1999, Wagner, Björn et. al.
Cytochrome P-450 dependent monooxygenases model system: rapid and efficient oxidation of primary aromatic amines to azo derivatives with sodium periodate catalyzed by manganese(III) Schiff base complexes
score: 0.84409679, Bioorganic & Medicinal Chemistry, 2004, Mirkhani, Valiollah et. al.
Novel Antibiofilm Chemotherapy Targets Exopolysaccharide Synthesis and Stress Tolerance in Streptococcus mutans To Modulate Virulence Expression In Vivo.
score: 0.84384416, Antimicrobial agents and chemotherapy, 2012, Falsetta, Megan L et. al.
Intracellular nucleotides of (-)-2',3'-deoxy-3'-thiacytidine in peripheral blood mononuclear cells of a patient infected with human immunodeficiency virus.
score: 0.84370807, Antimicrobial agents and chemotherapy, 1998, Solas, C; Li, Y F; Xie, M Y; Sommadossi, J P; Zhou, X J
Synthesis and binding properties of photoactivable biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein
score: 0.84367813, Bioorganic & Medicinal Chemistry, 1999, Teodori, Elisabetta et. al.
Fatty Acid Esters of Juvenoid Alcohols as Insect Hormonogen Agents (Juvenogens)
score: 0.84357982, Bioorganic & Medicinal Chemistry, 2002, Wimmer, Zdeněk et. al.
Synthesis and analgesic activity of novel N -acylarylhydrazones and isosters, derived from natural safrole # # This paper represents contribution # 36 of the LASSBio, UFRJ (Br.) (LASSBio, http://acd.ufrj.br/≈pharma/lassbio); For contribution # 35, see [24].
score: 0.84334132, European Journal of Medicinal Chemistry, 2000, Lima, Patrícia C. et. al.
The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA
score: 0.84331802, European Journal of Medicinal Chemistry, 2005, Sharples, Derek et. al.
Fluorescent Somatostatin Receptor Probes for the Intraoperative Detection of Tumor Tissue with Long-Wavelength Visible Light
score: 0.84329687, Bioorganic & Medicinal Chemistry, 2002, Mier, Walter; Beijer, Barbro; Graham, Keith; Hull, William E
Effect of nutritional status on response to treatment with artemisinin-based combination therapy in young Ugandan children with malaria.
score: 0.84256623, Antimicrobial agents and chemotherapy, 2011, Verret, Wendy J et. al.
Cryptoregiochemical analysis of an unusual bacterial desaturation
score: 0.84253529, Bioorganic & Medicinal Chemistry Letters, 2001, Fauconnot, Laëtitia; Buist, Peter H
Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor
score: 0.84245462, Bioorganic & Medicinal Chemistry, 2001, Scarpi, Dina et. al.
Moxifloxacin efficacy and vitreous penetration in a rabbit model of Staphylococcus aureus endophthalmitis and effect on gene expression of leucotoxins and virulence regulator factors.
score: 0.84225591, Antimicrobial agents and chemotherapy, 2003, Bronner, Stéphane et. al.
Total syntheses of three copper (II) tetracarboranylphenylporphyrins containing 40 or 80 boron atoms and their biological properties in EMT-6 tumor-bearing mice
score: 0.84210804, Bioorganic & Medicinal Chemistry, 2006, Wu, Haitao et. al.
Synthesis and antimuscarinic activity of some ether- and thioether-bearing 1,3-dioxolanes and related sulfoxides and sulfones
score: 0.84188566, Bioorganic & Medicinal Chemistry, 1998, Malmusi, Luca et. al.
Clinical correlates of antifungal macrodilution susceptibility test results for non-AIDS patients with severe Candida infections treated with fluconazole.
score: 0.84166078, Antimicrobial agents and chemotherapy, 2000, Lee, S C et. al.
Echinococcus multilocularis alkaline phosphatase as a marker for metacestode damage induced by in vitro drug treatment with albendazole sulfoxide and albendazole sulfone.
score: 0.84146872, Antimicrobial agents and chemotherapy, 2001, Stettler, M et. al.
Esters, amides and substituted derivatives of cinnamic acid: synthesis, antimicrobial activity and QSAR investigations
score: 0.84141502, European Journal of Medicinal Chemistry, 2004, Narasimhan, Balasubramanian et. al.
Characterization of a conjugate between Rose Bengal and chitosan for targeted antibiofilm and tissue stabilization effects as a potential treatment of infected dentin.
score: 0.84141047, Antimicrobial agents and chemotherapy, 2012, Shrestha, Annie; Hamblin, Michael R; Kishen, Anil
Solid-phase C–C and C–O bond forming reactions using ‘Traceless’ π-arene–chromium linkers
score: 0.84112296, Bioorganic & Medicinal Chemistry Letters, 2002, Rigby, James H; Kondratenko, Mikhail A
2D, 3D-QSAR and docking studies of 1,2,3-thiadiazole thioacetanilides analogues as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
score: 0.84102925, Organic and Medicinal Chemistry Letters, 2012, Jain, Shailesh V et. al.
Efficient glycoengineering of GM3 on melanoma cell and monoclonal antibody-mediated selective killing of the glycoengineered cancer cell
score: 0.84082358, Bioorganic & Medicinal Chemistry, 2007, Wang, Qianli; Zhang, Junping; Guo, Zhongwu
Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo
score: 0.84075807, European Journal of Medicinal Chemistry, 2012, Ichihara, Hideaki et. al.
Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure.
score: 0.84069608, Antimicrobial agents and chemotherapy, 2012, Caldwell, Shane J; Berghuis, Albert M
Investigation of the inhibition of leukotriene A 4 hydrolase
score: 0.84065181, Bioorganic & Medicinal Chemistry, 1995, Ollmann, Ian R. et. al.
Favorable interactions between enfuvirtide and 1-beta-D-2,6-diaminopurine dioxolane in vitro.
score: 0.8406477, Antimicrobial agents and chemotherapy, 2003, Tremblay, Cécile L et. al.
Platinum(II) complexes with steroidal esters of l-methionine and l-histidine: Synthesis, characterization and cytotoxic activity
score: 0.84064461, Bioorganic & Medicinal Chemistry, 2008, Kvasnica, Miroslav et. al.
Actions between neonicotinoids and key residues of insect nAChR based on an ab initio quantum chemistry study: Hydrogen bonding and cooperative π–π interaction
score: 0.84049932, Bioorganic & Medicinal Chemistry, 2007, Wang, Yanli; Cheng, Jiagao; Qian, Xuhong; Li, Zhong
Synthesis and cytotoxicity of new aminoterpenylquinones
score: 0.84041286, Bioorganic & Medicinal Chemistry, 2005, Miguel del Corral, José M. et. al.
Torsion angle based design of peptidomimetics: A dipeptidic template adopting β-I Turn (Ac-Aib-AzGly–NH 2)
score: 0.83990814, Bioorganic & Medicinal Chemistry, 2001, Ro, Seonggu et. al.
The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC)·poly(rG): Spectroscopic and viscometric study
score: 0.83982409, Bioorganic & Medicinal Chemistry, 2006, Sinha, Rangana et. al.
Corrigendum to “SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist” [Bioorg. Med. Chem. 17 (2009) 5247]
score: 0.83982006, Bioorganic & Medicinal Chemistry, 2010, Haydar, Simon N. et. al.
In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent
score: 0.83966323, Bioorganic & Medicinal Chemistry Letters, 2004, Yamamoto, Tatsuhiro et. al.
Regioselective substitution of 6,7-dichloroquinoline-5,8-dione: synthesis and X-ray crystal structure of 4a,10,11-triazabenzo[3,2- a]fluorene-5,6-diones
score: 0.83950649, Bioorganic & Medicinal Chemistry, 2003, Kim, Young-Shin et. al.
Synthesis and anti-tumor-promoting activity of glycoglycerolipid analogues lacking the glycerol backbone
score: 0.8394264, Bioorganic & Medicinal Chemistry, 2003, Colombo, Diego et. al.
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure
score: 0.83921766, European Journal of Medicinal Chemistry, 2012, Siddiqi, Zafar A. et. al.
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure
score: 0.83921766, European Journal of Medicinal Chemistry, 2012, Siddiqi, Zafar A. et. al.
Models for Superoxide Dismutases: Characterization of Mononuclear Cu(II), Fe(III), and Mn(II) Complexes with 4′,5′-Bis(salicylideneimino)benzo-15-crown-5
score: 0.83896068, Bioorganic & Medicinal Chemistry, 1999, Güner, Saadettin; Karaböcek, Serdar; Kaklikkaya, Islam
The factors that influence permeation across the blood–brain barrier
score: 0.83883746, European Journal of Medicinal Chemistry, 2004, Abraham, Michael H.
Polyamino acids as catalysts in asymmetric synthesis
score: 0.83814177, Bioorganic & Medicinal Chemistry, 1999, Porter, Michael J.; Roberts, Stanley M.; Skidmore, John
Evaluation of 99mTc(CO) 3 complex of 2-methyl-5-nitroimidazole as an agent for targeting tumor hypoxia
score: 0.8377086, Bioorganic & Medicinal Chemistry, 2006, Mallia, Madhava B. et. al.
Catechols from abietic acid
score: 0.83763502, Bioorganic & Medicinal Chemistry, 2003, Gigante, B et. al.
QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents
score: 0.83747188, European Journal of Medicinal Chemistry, 2004, Agrawal, Vijay K et. al.
Effective switch-on fluorescence sensing of zinc(II) ion by 8-aminoquinolino-β-cyclodextrin/adamantaneacetic acid system in water
score: 0.83717275, Bioorganic & Medicinal Chemistry, 2007, Chen, Yong; Han, Kun-Ying; Liu, Yu
Pharmacokinetic properties of conventional and double-dose sulfadoxine-pyrimethamine given as intermittent preventive treatment in infancy.
score: 0.83697427, Antimicrobial agents and chemotherapy, 2011, Salman, Sam et. al.
Search for α3β2/3γ2 subtype selective ligands that are stable on human liver microsomes
score: 0.83656988, Bioorganic & Medicinal Chemistry, 2013, Namjoshi, Ojas A. et. al.
Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure.
score: 0.83654267, Antimicrobial agents and chemotherapy, 2010, Betancor, Gilberto et. al.
Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists
score: 0.83613004, European Journal of Medicinal Chemistry, 2000, Sánchez, Isabel et. al.
3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents
score: 0.83580858, Bioorganic & Medicinal Chemistry, 2012, Kelley, Cody et. al.
Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones
score: 0.83580394, Bioorganic & Medicinal Chemistry, 2002, Park Choo, Hea-Young et. al.
Evidence supporting the activity of 2′- C-cyano-2′-deoxy-1- β-d- arabino-pentafuranosylcytosine as a terminator in enzymatic DNA-chain elongation
score: 0.83578487, Bioorganic & Medicinal Chemistry Letters, 1998, Hayakawa, Yoshihiro et. al.
A chemoenzymatic scalable route to optically active ( R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of β 3-adrenergic receptor agonists
score: 0.83577904, Bioorganic & Medicinal Chemistry, 2006, Perrone, Maria Grazia et. al.
Hesperetin: An inhibitor of the transforming growth factor-β (TGF-β) signaling pathway
score: 0.8357684, European Journal of Medicinal Chemistry, 2012, Yang, Yong et. al.
Hesperetin: An inhibitor of the transforming growth factor-β (TGF-β) signaling pathway
score: 0.8357684, European Journal of Medicinal Chemistry, 2012, Yang, Yong et. al.
Hesperetin: An inhibitor of the transforming growth factor-β (TGF-β) signaling pathway
score: 0.8357684, European Journal of Medicinal Chemistry, 2012, Yang, Yong et. al.
The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir, and penciclovir in vitro and in vivo.
score: 0.83556603, Antimicrobial agents and chemotherapy, 1998, Neyts, J; Andrei, G; De Clercq, E
Artificial metalloenzymes based on protein cavities: Exploring the effect of altering the metal ligand attachment position by site directed mutagenesis
score: 0.83552279, Bioorganic & Medicinal Chemistry Letters, 1999, Davies, Ronald R. et. al.
Hydropathic interaction analyses of small organic activators binding to antithrombin
score: 0.83539897, Bioorganic & Medicinal Chemistry, 2004, Gunnarsson, Gunnar T.; Desai, Umesh R.
E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group
score: 0.83534044, Bioorganic & Medicinal Chemistry, 1997, Schaschke, Norbert et. al.
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A 3
score: 0.83528948, Bioorganic & Medicinal Chemistry, 2003, Mir, Mohd Ayoub; Majee, Sangita; Das, Suman; Dasgupta, Dipak
The antifungal protein from Aspergillus giganteus causes membrane permeabilization.
score: 0.83527366, Antimicrobial agents and chemotherapy, 2003, Theis, T; Wedde, M; Meyer, V; Stahl, U
Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp
score: 0.83505916, Bioorganic & Medicinal Chemistry, 2008, Brito, Adriana S. et. al.
Molecular recognition of DNA by small molecules
score: 0.83498933, Bioorganic & Medicinal Chemistry, 2001, Dervan, Peter B.
Comparison of the In Vivo Pharmacokinetics and In Vitro Dissolution of Raltegravir in HIV Patients Receiving the Drug by Swallowing or by Chewing.
score: 0.83498736, Antimicrobial agents and chemotherapy, 2012, Cattaneo, Dario et. al.
Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines
score: 0.83460938, Bioorganic & Medicinal Chemistry, 2003, Lu, Xingliang et. al.
Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents
score: 0.8339867, European Journal of Medicinal Chemistry, 2012, Britton, Robert G. et. al.
Construction of hairpin ribozymes with a three-way junction
score: 0.83385184, Bioorganic & Medicinal Chemistry, 1997, Komatsu, Yasuo et. al.
An approach to the stereo-controlled synthesis of polycyclic derivatives of l-4-thiazolidinecarboxylic acid active against HIV-1 integrase
score: 0.83361211, European Journal of Medicinal Chemistry, 2006, Aiello, F. et. al.
Synthesis and binding properties of oligodeoxynucleotides containing phenylphosphon(othio)ate linkages
score: 0.8336021, Bioorganic & Medicinal Chemistry, 1997, Mag, Matthias et. al.
I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes
score: 0.83356546, Bioorganic & Medicinal Chemistry, 2007, Xu, Yan et. al.
Nonenzymatic sequence-specific cleavage of duplex DNA via triple-helix formation by homopyrimidine phosphorothioate oligonucleotides
score: 0.83348914, Bioorganic & Medicinal Chemistry, 1996, Tsukahara, Satoru et. al.
New synthetic trisaccharide inhibitors for N-acetylglucosaminyltransferase-V
score: 0.83348506, Bioorganic & Medicinal Chemistry, 1996, Lu, Pu-Ping et. al.
Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress.
score: 0.83300979, Antimicrobial agents and chemotherapy, 2004, Macvanin, Mirjana; Ballagi, Andras; Hughes, Diarmaid
Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-α and IL-4 production from RBL-2H3 cells
score: 0.83295851, Bioorganic & Medicinal Chemistry, 2002, Mastuda, Hisashi et. al.
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 7: assay and characterization of 7,8-diacetoxy-4-methylcoumarin:protein transacetylase from rat liver microsomes based on the irreversible inhibition of cytosolic glutathione S-Transferase
score: 0.83288991, Bioorganic & Medicinal Chemistry, 2000, Raj, Hanumantharao G et. al.
Sensitization of hyperthermic treatment of leukemic cell lines by a synthetic peptide
score: 0.83286307, Bioorganic & Medicinal Chemistry, 2002, Hori, Yasuharu et. al.
Thermodynamics of inclusion complexes of natural and modified cyclodextrins with propranolol in aqueous solution at 298 K
score: 0.83281145, Bioorganic & Medicinal Chemistry, 2006, Castronuovo, Giuseppina; Niccoli, Marcella
Prodrugs of biologically active phosphate esters
score: 0.83280479, Bioorganic & Medicinal Chemistry, 2003, Schultz, Carsten
Synthesis and structure–activity of antisense peptides corresponding to the region for CaM-binding domain of the inducible nitric oxide synthase 1 Symbols and abbreviations are in accord with recommendations from [1]
score: 0.83278206, European Journal of Medicinal Chemistry, 2000, Sautebin, Lidia et. al.
Characterization and DNA-interaction studies of 1,1-dicyano-2,2-ethylene dithiolate Ni(II) mixed-ligand complexes with 2-amino-5-methyl thiazole, 2-amino-2-thiazoline and imidazole. Crystal structure of [Ni(i-MNT)(2a-5mt) 2]
score: 0.83277326, Bioorganic & Medicinal Chemistry, 2009, Cox, Philip J.; Psomas, George; Bolos, Christos A.
Design, synthesis and in vitro evaluation of pyridinium ion based cyclase inhibitors and antifungal agents
score: 0.83250061, Bioorganic & Medicinal Chemistry, 1996, Rose, Ingo C. et. al.
Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
score: 0.83237908, Antimicrobial agents and chemotherapy, 2012, Chinsangaram, Jarasvech et. al.
Structural changes of benzylether derivatives of vesamicol and their influence on the binding selectivity to the vesicular acetylcholine transporter
score: 0.83237136, European Journal of Medicinal Chemistry, 2005, Wenzel, Barbara et. al.
Amphotericin B interactions with soluble oligomers of amyloid Aβ1-42 peptide
score: 0.83236263, Bioorganic & Medicinal Chemistry, 2009, Smith, Nicholas W.; Annunziata, Onofrio; Dzyuba, Sergei V.
Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin β4 in A549 human lung cancer cells
score: 0.83236079, Bioorganic & Medicinal Chemistry, 2006, Du, AiYing et. al.
Characterization of a glycosyl transferase inactivating macrolides, encoded by gimA from Streptomyces ambofaciens.
score: 0.8322895, Antimicrobial agents and chemotherapy, 1998, Gourmelen, A; Blondelet-Rouault, M H; Pernodet, J L
Coupling between substrate binding and allosteric regulation in ribozyme catalysis
score: 0.83208674, Bioorganic & Medicinal Chemistry, 2001, Araki, Michihiro et. al.
In vitro and in vivo evaluations of THAM derived telomers bearing RGD and Ara-C for tumour neovasculature targeting
score: 0.83202143, European Journal of Medicinal Chemistry, 2003, Jasseron, S. et. al.
Cellular uptake of covalent conjugates of oligonucleotide with membrane-modifying peptide, peptaibol
score: 0.83191688, Bioorganic & Medicinal Chemistry, 2012, Wada, Shun-ichi et. al.
Cellular uptake of covalent conjugates of oligonucleotide with membrane-modifying peptide, peptaibol
score: 0.83191688, Bioorganic & Medicinal Chemistry, 2012, Wada, Shun-ichi et. al.
Cellular uptake of covalent conjugates of oligonucleotide with membrane-modifying peptide, peptaibol
score: 0.83191688, Bioorganic & Medicinal Chemistry, 2012, Wada, Shun-ichi et. al.
Fungal beta-tubulin, expressed as a fusion protein, binds benzimidazole and phenylcarbamate fungicides.
score: 0.83178761, Antimicrobial agents and chemotherapy, 1998, Hollomon, D W; Butters, J A; Barker, H; Hall, L
Design, synthesis and herbicidal activity of new iron chelating motifs for HPPD-inhibitors
score: 0.8314544, Bioorganic & Medicinal Chemistry, 2009, Witschel, Matthias
Inhibition of neutrophil O 2 − production by unsymmetrical methylene derivatives of benzopyrans: their use as potential antiinflammatory agents
score: 0.83132497, European Journal of Medicinal Chemistry, 2001, Mazzei, Mauro et. al.
Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles
score: 0.83129794, European Journal of Medicinal Chemistry, 2005, Kazimierczuk, Z. et. al.
Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-Coenzyme A
score: 0.83122569, Bioorganic & Medicinal Chemistry Letters, 2001, Kershaw, Nadia J et. al.
Dialkylaminoalkylnaphthalenes as novel opioid-like analgesics
score: 0.83118798, Bioorganic & Medicinal Chemistry, 2000, Collina, Simona et. al.
SRS-A antagonist pyranoquinolone alkaloids from East African Fagara plants and their synthesis
score: 0.8310842, Bioorganic & Medicinal Chemistry, 1996, Kamikawa, Tadao et. al.
Insights into the physiological role of pig liver esterase: Isoenzymes show differences in the demethylation of prenylated proteins
score: 0.83090453, Bioorganic & Medicinal Chemistry, 2009, Brüsehaber, Elke; Böttcher, Dominique; Bornscheuer, Uwe T.
Deuterium isotope effects and product studies for the oxidation of N ω-allyl- l-arginine and N ω-allyl- N ω-hydroxy- l-arginine by neuronal nitric oxide synthase
score: 0.83087168, Bioorganic & Medicinal Chemistry, 2000, Hah, Jung-Mi; Roman, Linda J; Silverman, Richard B
A new aspect of view in synthesizing new type β-adrenoceptor blockers with ancillary antioxidant activities
score: 0.83081789, Bioorganic & Medicinal Chemistry, 2001, Huang, Yeun-Chih et. al.
Structure–activity and structure–metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure
score: 0.83075932, Bioorganic & Medicinal Chemistry, 2004, Mimoto, Tsutomu et. al.
Channel formation by CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii.
score: 0.83071513, Antimicrobial agents and chemotherapy, 2005, Siroy, Axel et. al.
Metabolism and selective toxicity of 6-nitrobenzylthioinosine in Toxoplasma gondii.
score: 0.8301965, Antimicrobial agents and chemotherapy, 1999, el Kouni, M H et. al.
Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cells
score: 0.82975924, Bioorganic & Medicinal Chemistry, 2005, Mishima, Satoshi et. al.
Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergy
score: 0.82957747, European Journal of Medicinal Chemistry, 2006, Richards, Mark L. et. al.
Enzymatic Synthesis of Monocyclic β-Lactams
score: 0.82913484, Bioorganic & Medicinal Chemistry Letters, 2002, Sleeman, Mark C et. al.
Ring-substituted histaprodifen analogues as partial agonists for histamine H 1 receptors: synthesis and structure–activity relationships # # Presented in part: XIIIth International Congress of Pharmacology, Munich, July 26–31, 1998 [1]
score: 0.82902592, European Journal of Medicinal Chemistry, 2000, Elz, Sigurd et. al.
Cell surface biotinylation by azaelectrocyclization: Easy-handling and versatile approach for living cell labeling
score: 0.82887628, Bioorganic & Medicinal Chemistry, 2012, Tanaka, Katsunori et. al.
Bromal-derived tetrahydro-β-carbolines as neurotoxic agents: chemistry, impairment of the dopamine metabolism, and inhibitory effects on mitochondrial respiration
score: 0.82854681, Bioorganic & Medicinal Chemistry, 2000, Bringmann, Gerhard et. al.
Quantitative structure–activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: Molecular modeling, CoMFA and CoMSIA studies
score: 0.82846714, Journal of Molecular Graphics and Modelling, 2009, Trossini, Gustavo H.G. et. al.
Preparation of antigens and immunoadsorbents corresponding to the Streptococcus group a cell-wall polysaccharide
score: 0.82835674, Bioorganic & Medicinal Chemistry, 1996, Auzanneau, France-Isabelle; Pinto, B.Mario
Why B-ring is the active center for genistein to scavenge peroxyl radical: A DFT study
score: 0.8282041, Bioorganic & Medicinal Chemistry Letters, 2003, Zhang, Hong-Yu; Wang, Lan-Fen; Sun, You-Min
Occurrence of antioxidant and radical scavenging proanthocyanidins from the Indian minor spice nagkesar ( Mammea longifolia planch and triana syn)
score: 0.82802201, Bioorganic & Medicinal Chemistry, 2004, Jagan Mohan Rao, Lingamallu et. al.
Soluble polymer traceless linker investigations: Solvent effects on the desulfonylation of polyethylene glycol (PEG) substituted aryl alkyl sulfones with sodium amalgam
score: 0.82786626, Bioorganic & Medicinal Chemistry Letters, 1998, Zhao, Xu-yang; Janda, Kim D.
Oral bioavailability and pharmacokinetics of trovafloxacin in patients with AIDS.
score: 0.82780506, Antimicrobial agents and chemotherapy, 1999, Lacy, M K et. al.
Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: A correlation?
score: 0.82765971, Bioorganic & Medicinal Chemistry, 2012, Böttger, Stefan; Hofmann, Katja; Melzig, Matthias F.
Gramicidin-based channel systems for the detection of protein–ligand interaction
score: 0.82727098, Bioorganic & Medicinal Chemistry, 2004, Futaki, Shiroh et. al.
S-2-Amino-5-azolylpentanoic Acids Related to l-Ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS)
score: 0.82723864, Bioorganic & Medicinal Chemistry, 1998, Ulhaq, Saraj et. al.
Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer.
score: 0.82712603, Nature chemical biology, 2010, Miller Jenkins, Lisa M et. al.
Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes
score: 0.82705455, Bioorganic & Medicinal Chemistry, 2004, Cui, Yong-Mei et. al.
Recognizing and exploiting differences between RNAi and small-molecule inhibitors.
score: 0.82705413, Nature chemical biology, 2007, Weiss, William A; Taylor, Stephen S; Shokat, Kevan M
Metabolism resistant isothiazolone inhibitors of cartilage breakdown
score: 0.82643661, Bioorganic & Medicinal Chemistry, 1995, Wright, Stephen W. et. al.
Tin(IV) complexes of pyrrolidinedithiocarbamate: synthesis, characterisation and antifungal activity
score: 0.82635027, European Journal of Medicinal Chemistry, 2005, Menezes, D.C. et. al.
Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.
score: 0.82633753, Antimicrobial agents and chemotherapy, 2006, Alcazar-Fuoli, Laura et. al.
NO-donors, part 9 [1]: diazeniumdiolates inhibit human platelet aggregation and induce a transient vasodilatation of porcine pulmonary arteries in accordance with the NO-releasing rates
score: 0.82622426, European Journal of Medicinal Chemistry, 2005, Abuo-Rahma, Gamal El Din A.A. et. al.
UVC light prophylaxis for cutaneous wound infections in mice.
score: 0.8261048, Antimicrobial agents and chemotherapy, 2012, Dai, Tianhong et. al.
Design, synthesis and activity of bisubstrate, transition-state analogues and competitive inhibitors of aspartate transcarbamylase
score: 0.82605094, European Journal of Medicinal Chemistry, 2004, Grison, Claude et. al.
Polymeric grape-seed procyanidins, but not monomeric catechins and oligomeric procyanidins, impair degranulation and membrane ruffling in RBL-2H3 cells
score: 0.8259239, Bioorganic & Medicinal Chemistry, 2006, Kondo, Kazunari et. al.
A DOTA–peptide conjugate by copper-free click chemistry
score: 0.82556181, Bioorganic & Medicinal Chemistry Letters, 2010, Martin, Molly E. et. al.
Bacteriological efficacies of three macrolides compared with those of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae.
score: 0.82536301, Antimicrobial agents and chemotherapy, 1998, Berry, V; Thorburn, C E; Knott, S J; Woodnutt, G
Coaggregate of amphiphilic zinc chlorins with synthetic surfactants in an aqueous medium to an artificial supramolecular light-harvesting system
score: 0.82526402, Bioorganic & Medicinal Chemistry, 2004, Miyatake, Tomohiro et. al.
Evaluation of antibiotic treatment against "Candidatus Helicobacter suis" in a mouse model.
score: 0.82507948, Antimicrobial agents and chemotherapy, 2005, Hellemans, A; Decostere, A; Haesebrouck, F; Ducatelle, R
Interactions of sodium and potassium ions with oligonucleotides carrying human telomeric sequence and pyrene moieties at both termini
score: 0.8247667, Bioorganic & Medicinal Chemistry, 2008, Hayashida, Hirohisa et. al.
Inhibition of protein phosphatases by Michael adducts of ascorbic acid analogues with α,β-unsaturated carbonyl compounds
score: 0.82474106, Bioorganic & Medicinal Chemistry, 2000, Witt, U.G; Schultz, J.E; Dölker, M; Eger, K
On the Search for potential anti-trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry Reactions
score: 0.82473043, European Journal of Medicinal Chemistry, 2012, da Silva Júnior, Eufrânio N. et. al.
Pharmacophore and QSAR modeling of estrogen receptor β ligands and subsequent validation and in silico search for new hits
score: 0.82467052, Journal of Molecular Graphics and Modelling, 2010, Taha, Mutasem O. et. al.
Ergot alkaloid glycosides with immunomodulatory activities
score: 0.82462162, Bioorganic & Medicinal Chemistry, 1996, Křen, Vladimír et. al.
Highly efficient controllable oxidation of alcohols to aldehydes and acids with sodium periodate catalyzed by water-soluble metalloporphyrins as biomimetic catalyst
score: 0.82461647, Bioorganic & Medicinal Chemistry, 2010, Ren, Qing-Gang et. al.
Salt-resistant alpha-helical cationic antimicrobial peptides.
score: 0.82455261, Antimicrobial agents and chemotherapy, 1999, Friedrich, C et. al.
Oxidative deamination of benzylamine by glycoxidation
score: 0.824462, Bioorganic & Medicinal Chemistry, 2003, Akagawa, Mitsugu; Sasaki, Takeshi; Suyama, Kyozo
Rapid solid-Phase synthesis of DNA-Binding pyrrole-Imidazole polyamides
score: 0.82439591, Bioorganic & Medicinal Chemistry Letters, 2002, Krutzik, Peter O.; Chamberlin, A.Richard
Novel fluorogenic substrates for acid phosphatase
score: 0.82434993, Bioorganic & Medicinal Chemistry Letters, 1999, Gee, Kyle R.
A novel spectrophotometric method for the determination of aminophylline with boric acid in pharmaceutical and mixed serum samples
score: 0.82428999, European Journal of Medicinal Chemistry, 2009, Li, Quanmin; Zhang, Tiantian; Lv, Wenying
Evaluation of copper chelation agents as anti-angiogenic therapy
score: 0.82422901, Bioorganic & Medicinal Chemistry, 2003, Camphausen, Kevin et. al.
Novel 99mTc ‘4 + 1’ peptide conjugates: Tuning the biodistribution by variation of coligands
score: 0.82422591, European Journal of Medicinal Chemistry, 2010, Kunstler, Jens-Uwe et. al.
The selection in vivo and characterization of an RNA recognition motif for spectinomycin
score: 0.82412632, Bioorganic & Medicinal Chemistry, 1997, Thom, George; Prescott, Catherine D.
Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: role in multiple antibiotic resistance.
score: 0.82412625, Antimicrobial agents and chemotherapy, 2004, Eaves, Deborah J; Ricci, Vito; Piddock, Laura J V
Synthesis and properties of oligo-2′-deoxyribonucleotides containing internucleotidic phosphoramidate linkages modified with pendant groups ending with either two amino or two hydroxyl functions
score: 0.82391288, Bioorganic & Medicinal Chemistry, 2003, Asseline, Ulysse et. al.
Synthesis, characterization, cytotoxic activities, and DNA-binding properties of the La(III) complex with Naringenin Schiff-base
score: 0.82353147, Bioorganic & Medicinal Chemistry, 2006, Wang, Bao-dui et. al.
Peptide-derived transition state analogue inhibitors of thrombin; Synthesis, activity and selectivity
score: 0.82352043, Bioorganic & Medicinal Chemistry, 1995, Jetten, Mieke et. al.
Five-membered ring azasugars as potent inhibitors of α-L-rhamnosidase (naringinase) from Penicillium decumbens
score: 0.82341202, Bioorganic & Medicinal Chemistry, 1994, Provencher, Louis; Steensma, Darryl H.; Wong, Chi-Huey
Missing in action: enzyme functional annotations in biological databases.
score: 0.82337651, Nature chemical biology, 2009, Furnham, Nicholas et. al.
Pyrazolo-triazoles as light activable dna cleaving agents
score: 0.82334574, Bioorganic & Medicinal Chemistry, 2000, Manfredini, Stefano et. al.
Antiretroviral drug resistance in human immunodeficiency virus type 2.
score: 0.82319807, Antimicrobial agents and chemotherapy, 2009, Ntemgwa, Michel L et. al.
Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals
score: 0.82314002, Bioorganic & Medicinal Chemistry Letters, 2005, Enholm, Eric; Joshi, Aarti; Wright, Dennis L.
2-(4,5-Dihydroimidazol-2-yl)benzimidazoles as highly selective imidazoline I 2/adrenergic α 2 receptor ligands
score: 0.82263371, Bioorganic & Medicinal Chemistry, 2006, Sączewski, Francieszek et. al.
A density functional study of flavonoid compounds with anti-HIV activity
score: 0.82237532, European Journal of Medicinal Chemistry, 2006, Lameira, J.; Alves, C.N.; Moliner, V.; Silla, E.
Molybdophyllysin, a toxic metalloendopeptidase from the tropical toadstool, Chlorophyllum molybdites
score: 0.82219409, Bioorganic & Medicinal Chemistry, 2012, Yamada, Mina et. al.
Molybdophyllysin, a toxic metalloendopeptidase from the tropical toadstool, Chlorophyllum molybdites
score: 0.82219409, Bioorganic & Medicinal Chemistry, 2012, Yamada, Mina et. al.
Molybdophyllysin, a toxic metalloendopeptidase from the tropical toadstool, Chlorophyllum molybdites
score: 0.82219409, Bioorganic & Medicinal Chemistry, 2012, Yamada, Mina et. al.
Antibacterial efficacy of R-type pyocins towards Pseudomonas aeruginosa in a murine peritonitis model.
score: 0.82209965, Antimicrobial agents and chemotherapy, 2008, Scholl, Dean; Martin, David W
Development of enzymatic assays for quantification of intracellular lamivudine and carbovir triphosphate levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients.
score: 0.82204147, Antimicrobial agents and chemotherapy, 2002, Kewn, Stephen et. al.
Novel pyrrolinones as N-methyl- d-aspartate receptor antagonists
score: 0.82186805, European Journal of Medicinal Chemistry, 2005, Poschenrieder, Hermann et. al.
Formation of 2-chloroinosine from guanosine by treatment of HNO 2 in the presence of NaCl
score: 0.82186544, Bioorganic & Medicinal Chemistry, 2001, Suzuki, Toshinori et. al.
Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-Steroidal Anti-Inflammatory Drugs in the Presence of Polyamidoamine Dendrimers
score: 0.82178219, European Journal of Medicinal Chemistry, 2005, Yiyun, Cheng; Tongwen, Xu
Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors
score: 0.82149904, Nature chemical biology, 2011, Adibekian, Alexander et. al.
Pegylation of antimicrobial peptides maintains the active peptide conformation, model membrane interactions, and antimicrobial activity while improving lung tissue biocompatibility following airway delivery.
score: 0.82129366, Antimicrobial agents and chemotherapy, 2012, Morris, Christopher J et. al.
Mechanisms of azole resistance in a clinical isolate of Candida tropicalis.
score: 0.82114816, Antimicrobial agents and chemotherapy, 2005, Vandeputte, Patrick et. al.
Synthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group
score: 0.82112191, Bioorganic & Medicinal Chemistry, 2003, Li, Ying et. al.
Resistance to antimicrobial peptides and stress response in Mycoplasma pulmonis.
score: 0.82108062, Antimicrobial agents and chemotherapy, 2005, Fehri, Lina Fassi et. al.
Properties of diacetyl (acetoin) reductase from Bacillus stearothermophilus
score: 0.82097089, Bioorganic & Medicinal Chemistry, 1996, Paolo Giovannini, P. et. al.
Discordances between interpretation algorithms for genotypic resistance to protease and reverse transcriptase inhibitors of human immunodeficiency virus are subtype dependent.
score: 0.82085578, Antimicrobial agents and chemotherapy, 2006, Snoeck, Joke et. al.
Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF.
score: 0.82085492, Antimicrobial agents and chemotherapy, 2002, Sánchez, Patricia; Alonso, Ana; Martinez, Jose L
Phenanthrenequinone antiretroviral agents
score: 0.82058373, Bioorganic & Medicinal Chemistry Letters, 2000, Kraus, George A. et. al.
Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3′-termini
score: 0.82046574, Bioorganic & Medicinal Chemistry, 2008, Ueno, Yoshihito et. al.
Interaction of the disodium disuccinate derivative of meso-Astaxanthin with human serum albumin: from chiral complexation to self-Assembly
score: 0.82024481, Bioorganic & Medicinal Chemistry Letters, 2003, Zsila, Ferenc; Simonyi, Miklós; Lockwood, Samuel F
An efficient oxidizing reagent for the synthesis of mixed backbone oligonucleotides via the h-Phosphonate approach
score: 0.82010183, Bioorganic & Medicinal Chemistry, 2003, Mohe, Nikhil U; Padiya, Kamlesh J; Salunkhe, Manikrao M
The pyrrole moiety as a template for COX-1/COX-2 inhibitors
score: 0.82001073, European Journal of Medicinal Chemistry, 2000, Dannhardt, Gerd et. al.
Synthesis and SAR of 5-, 6-, 7- and 8-Aza Analogues of 3-Aryl-4-hydroxyquinolin-2(1 H)-one as NMDA/Glycine Site Antagonists
score: 0.81990666, Bioorganic & Medicinal Chemistry, 2001, Zhou, Zhang-Lin et. al.
Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei
score: 0.81988065, Chemmedchem, 2009, Spinks, Daniel et. al.
Pictet–Spengler condensation of the antiparkinsonian drug l-DOPA with d-glyceraldehyde. Opposite kinetic effects of Fe 3+ and Cu 2+ ions and possible implications for the origin of therapeutic side effects
score: 0.8198527, Bioorganic & Medicinal Chemistry, 2001, Manini, Paola; d'Ischia, Marco; Prota, Giuseppe
A behaviorally selective class of thiophene-containing benzodiazepine receptor ligands
score: 0.81970044, Bioorganic & Medicinal Chemistry, 1995, Schove, Laura T. et. al.
Self-aggregates of a synthetic cadmium chlorin in solid film as a photosynthetic antenna model
score: 0.81963613, Bioorganic & Medicinal Chemistry, 1999, Amakawa, Masaaki; Tamiaki, Hitoshi
Synthesis of pavoninin-1, a shark repellent substance, and its structural analogues toward mechanistic studies on their membrane perturbation
score: 0.81951286, Bioorganic & Medicinal Chemistry, 1997, Ohnishi, Yuki; Tachibana, Kazuo
Preparation and anticoagulant activity of the phosphosulfomannan PI-88
score: 0.81939407, European Journal of Medicinal Chemistry, 2002, Yu, Guangli et. al.
Mapping of the active site of rat kidney γ-glutamyl transpeptidase using activated esters and their amide derivatives
score: 0.81932412, Bioorganic & Medicinal Chemistry, 2002, Castonguay, Roselyne; Lherbet, Christian; Keillor, Jeffrey W
A chemoenzymatic synthesis of UDP-(2-deoxy-2-fluoro)galactose and evaluation of its interaction with galactosyltransferase
score: 0.81917532, Bioorganic & Medicinal Chemistry, 1997, Hayashi, Takashi; Murray, Brion W; Wang, Ruo; Wong, Chi-Huey
Synthesis and antileishmanial profile of some novel terpenyl pyrimidines
score: 0.81917363, European Journal of Medicinal Chemistry, 2004, Pandey, Susmita et. al.
Predicting cytotoxicity from heterogeneous data sources with Bayesian learning
score: 0.81911029, Journal of Cheminformatics, 2010, Langdon, Sarah R et. al.
Cloning of S-adenosyl-L-methionine:C-24-Delta-sterol-methyltransferase (ERG6) from Leishmania donovani and characterization of mRNAs in wild-type and amphotericin B-Resistant promastigotes.
score: 0.81910389, Antimicrobial agents and chemotherapy, 2004, Pourshafie, Mohammad et. al.
Retention behavior of phenoxyacetic herbicides on a molecularly imprinted polymer with phenoxyacetic acid as a dummy template molecule
score: 0.81904569, Bioorganic & Medicinal Chemistry, 2007, Zhang, Huiting et. al.
Comparative 3D QSAR study on β 1 -, β 2 -, and β 3 -adrenoceptor agonists
score: 0.81899697, Medicinal Chemistry Research, 2009, Senthil Kumar, P.; Bharatam, Prasad V.
Binding of β- d-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies
score: 0.81885012, Bioorganic & Medicinal Chemistry, 2005, Chrysina, Evangelia D. et. al.
Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin
score: 0.81876591, Bioorganic & Medicinal Chemistry, 1999, Raj, Hanumantharao G et. al.
Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis.
score: 0.81860421, Antimicrobial agents and chemotherapy, 1999, Billington, O J; McHugh, T D; Gillespie, S H
Effects of piperine analogues on stimulation of melanocyte proliferation and melanocyte differentiation
score: 0.81850287, Bioorganic & Medicinal Chemistry, 2004, Venkatasamy, Radhakrishnan et. al.
Synthesis of acridine-nuclear localization signal (NLS) conjugates and evaluation of their impact on lipoplex and polyplex-based transfection
score: 0.81843263, European Journal of Medicinal Chemistry, 2005, Boulanger, Caroline et. al.
Structure-affinity relationships of baclofen and 3-heteroaromatic analogues
score: 0.81826978, Bioorganic & Medicinal Chemistry, 1995, Pirard, Bernard et. al.
The MCL-1 BH3 Helix is an Exclusive MCL-1 inhibitor and Apoptosis Sensitizer
score: 0.8180885, Nature chemical biology, 2010, Stewart, Michelle L. et. al.
Synthesis of 17β- N-Substituted 19-Nor-10-azasteroids as Inhibitors of Human 5α-Reductases I and II
score: 0.81791361, Bioorganic & Medicinal Chemistry, 2002, Scarpi, Dina et. al.
Generation-dependent encapsulation/electrostatic attachment of phenobarbital molecules by poly(amidoamine) dendrimers: Evidence from 2D-NOESY investigations
score: 0.81790309, European Journal of Medicinal Chemistry, 2009, Cheng, Yiyun et. al.
In search of new chemical entities with spermicidal and anti-HIV activities
score: 0.81753758, Bioorganic & Medicinal Chemistry, 1999, Srivastava, Seema et. al.
Structure–activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor
score: 0.81738211, European Journal of Medicinal Chemistry, 2005, Dar, D.E. et. al.
Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats.
score: 0.81734837, Antimicrobial agents and chemotherapy, 2002, Naruhashi, Kazumasa et. al.
Chemical investigation of Mycale mytilorum and a study on toxicity and antidiabetic activity of 5-Octadecylpyrrole-2-carboxaldehyde
score: 0.81716518, Bioorganic & Medicinal Chemistry, 2000, Bala Show Reddy, G.; Dhananjaya, N.
Space-filling effects in membrane disruption by cationic amphiphiles
score: 0.81677189, Bioorganic & Medicinal Chemistry, 2001, Fujiwara, Tomoko et. al.
Identification of preferred actinomycin–DNA binding sites by the combinatorial method REPSA
score: 0.81676236, Bioorganic & Medicinal Chemistry, 2001, Shen, Jing; Wang, Jo C.; Van Dyke, Michael W.
Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics
score: 0.81636117, Bioorganic & Medicinal Chemistry, 1998, Qian, Yimin et. al.
Astersedifolioside A–C, three new oleane-type saponins with antiproliferative activity
score: 0.81625778, Bioorganic & Medicinal Chemistry, 2004, Corea, Gabriella et. al.
A SPR strategy for high-throughput ligand screenings based on synthetic peptides mimicking a selected subdomain of the target protein: A proof of concept on HER2 receptor
score: 0.81620281, Bioorganic & Medicinal Chemistry, 2009, Monfregola, Luca et. al.
Effects of frozen conditions on stereoselectivity and velocity of O-glycosylation reactions
score: 0.81607104, Bioorganic & Medicinal Chemistry, 2010, Ishiwata, Akihiro et. al.
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv
score: 0.81601784, Tuberculosis, 2009, Ananthan, Subramaniam et. al.
Fluorescence quenching properties of multiple pyrene-modified RNAs
score: 0.81599825, Bioorganic & Medicinal Chemistry, 2009, Maie, Kenji et. al.
Antidiabetic copper(II)-picolinate: Impact of the first transition metal in the metallopicolinate complexes
score: 0.81596226, Bioorganic & Medicinal Chemistry, 2007, Yasumatsu, Naoko et. al.
Aspects of oligonucleotide and peptide sequencing with MALDI and electrospray mass spectrometry
score: 0.81592018, Bioorganic & Medicinal Chemistry, 1998, Owens, David R et. al.
Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs
score: 0.8158917, European Journal of Medicinal Chemistry, 2012, Panda, Parthasarathi et. al.
Chiral switch of enzymatic ketone reduction by addition of γ-cyclodextrin
score: 0.81580286, Bioorganic & Medicinal Chemistry, 2010, Petkova, Galina A.; Král, Vladimír
Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities
score: 0.81578434, Bioorganic & Medicinal Chemistry, 2004, Sang, Shengmin et. al.
Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen
score: 0.81557273, European Journal of Medicinal Chemistry, 2005, Khan, M.S.Y.; Akhter, Mymoona
Further syntheses employing phosphorylase
score: 0.81546474, Bioorganic & Medicinal Chemistry, 1997, Evers, Britta; Thiem, Joachim
PEGylation of Neuromedin U Yields a Promising Candidate for the Treatment of Obesity and Diabetes
score: 0.81530352, Bioorganic & Medicinal Chemistry, 2012, Ingallinella, Paolo et. al.
Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine
score: 0.81530041, European Journal of Medicinal Chemistry, 2005, Decker, Michael
( E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties
score: 0.81523228, European Journal of Medicinal Chemistry, 2002, Balsamo, Aldo et. al.
Higher order iminodiacetic acid libraries for probing protein–protein interactions
score: 0.81508077, Bioorganic & Medicinal Chemistry, 1998, Boger, Dale L. et. al.
Molecular drug design, synthesis and crystal structure determination of CuII–SnIV heterobimetallic core: DNA binding and cleavage studies
score: 0.81500647, European Journal of Medicinal Chemistry, 2012, Arjmand, Farukh et. al.
Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization
score: 0.81499738, Bioorganic & Medicinal Chemistry Letters, 2007, Edupuganti, Om P. et. al.
Identification of NovelAntimalarial Chemotypes via Chemoinformatic Compound Selection Methodsfor a High-Throughput Screening Program against the Novel MalarialTarget, PfNDH2: Increasing Hit Rate via Virtual Screening Methods
score: 0.81494871, Journal of Medicinal Chemistry, 2012, Sharma, Raman et. al.
Puzzling through fragment-based drug design.
score: 0.8147671, Nature chemical biology, 2006, Hajduk, Philip J
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.
score: 0.81468663, Nature chemical biology, 2006, Watanabe, Kenji et. al.
The influence of hydroquinone on tyrosinase kinetics
score: 0.81409054, Bioorganic & Medicinal Chemistry, 2012, Stratford, Michael R.L. et. al.
Two New β-strand Mimics
score: 0.81405654, Bioorganic & Medicinal Chemistry, 1999, Tsai, James H.; Waldman, Amy Sue; Nowick, James S.
Determination of the diastereoisomeric purity of d,l- and meso-HM-PAO by 13C-NMR spectroscopy
score: 0.81405434, European Journal of Medicinal Chemistry, 2003, Kurteva, Vanya; Simova, Svetlana
4-Aryl-4 H -naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities
score: 0.81401387, DARU Journal of Pharmaceutical Sciences, 2012, Rafinejad, Ali et. al.
Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor.
score: 0.81397316, Antimicrobial agents and chemotherapy, 2001, Servais, J et. al.
Synthetic RNA circuits.
score: 0.81386682, Nature chemical biology, 2007, Davidson, Eric A; Ellington, Andrew D
Superoxide dismutase mimetics: synthesis and structure–activity relationship study of MnTBAP analogues
score: 0.81382173, Bioorganic & Medicinal Chemistry, 2002, Gauuan, Polivina Jolicia F et. al.
CCK 2 receptor antagonists containing the conformationally constrained phenylalanine derivatives, including the new amino acid Xic
score: 0.81374766, European Journal of Medicinal Chemistry, 2002, Gibson (née Thomas), Susan E et. al.
Ratiometric multimodal chemosensors based on cubic silsesquioxanes for monitoring solvent polarity
score: 0.81369677, Bioorganic & Medicinal Chemistry, 2008, Tanaka, Kazuo; Inafuku, Kenichi; Chujo, Yoshiki
β-Peptides as inhibitors of protein–protein interactions
score: 0.81364273, Bioorganic & Medicinal Chemistry, 2005, Kritzer, Joshua A. et. al.
Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents
score: 0.81344901, Bioorganic & Medicinal Chemistry Letters, 2012, Goel, Richa et. al.
Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents
score: 0.81344901, Bioorganic & Medicinal Chemistry Letters, 2012, Goel, Richa et. al.
Paviosides A–H, eight new oleane type saponins from Aesculus pavia with cytotoxic activity
score: 0.81330128, Bioorganic & Medicinal Chemistry, 2012, Lanzotti, Virginia et. al.
Paviosides A–H, eight new oleane type saponins from Aesculus pavia with cytotoxic activity
score: 0.81330128, Bioorganic & Medicinal Chemistry, 2012, Lanzotti, Virginia et. al.
Synthesis and immunosuppressive activity of new artemisinin derivatives. Part 2: 2-[12(β or α)-Dihydroartemisinoxymethyl(or 1′-ethyl)]phenoxyl propionic acids and esters
score: 0.81285824, Bioorganic & Medicinal Chemistry, 2006, Yang, Zhong-Shun et. al.
Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms.
score: 0.81279455, Antimicrobial agents and chemotherapy, 2005, Winters, Mark A; Merigan, Thomas C
Synthesis and antimicrobial activity of the symmetric dimeric form of temporin A based on 3- N, N-di(3-aminopropyl)amino propanoic acid as the branching unit
score: 0.81278763, Bioorganic & Medicinal Chemistry, 2001, Hujakka, Helena et. al.
Synthesis of 2-amino-2-deoxy-β-glycosyl-(1→5)-nucleosides and the interaction with RNA
score: 0.81265531, Bioorganic & Medicinal Chemistry, 2003, Zhang, Guisheng et. al.
In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs.
score: 0.81259285, Antimicrobial agents and chemotherapy, 2003, Alcalá, Luis et. al.
Antitumor agents—CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis
score: 0.81237176, Bioorganic & Medicinal Chemistry, 1997, Shi, Qian et. al.
Efficient oxidative decarboxylation of carboxylic acids with sodium periodate catalyzed by supported manganese (III) porphyrin
score: 0.81186719, Bioorganic & Medicinal Chemistry Letters, 2003, Mirkhani, Valiollah et. al.
Pharmacokinetics of lopinavir in HIV-infected adults receiving rifampin with adjusted doses of lopinavir-ritonavir tablets.
score: 0.81130598, Antimicrobial agents and chemotherapy, 2011, Decloedt, Eric H et. al.
In vitro activities of strychnos alkaloids and extracts against Plasmodium falciparum.
score: 0.81123078, Antimicrobial agents and chemotherapy, 1999, Frederich, M; Hayette, M P; Tits, M; De Mol, P; Angenot, L
Synthesis and antineoplastic activity of cyclolignan aldehydes
score: 0.81122338, European Journal of Medicinal Chemistry, 2000, Gordaliza, Marina et. al.
Microwave assisted solvent free synthesis of 1,3-diphenylpropenones
score: 0.81103198, Chemistry Central Journal, 2011, Kakati, Dwipen; Sarma, Jadab C
A study of the stability of tri(glucosyloxyphenyl)chlorin, a sensitizer for photodynamic therapy, in human colon tumoural cells: a liquid chromatography and MALDI-TOF mass spectrometry analysis
score: 0.81091776, Bioorganic & Medicinal Chemistry, 2004, Laville, I et. al.
Inducing the replacement of PNA in DNA·PNA duplexes by DNA
score: 0.81069301, Bioorganic & Medicinal Chemistry, 2008, Grossmann, Tom N. et. al.
Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes.
score: 0.81056416, Antimicrobial agents and chemotherapy, 1999, Ingold, K et. al.
Noble metals strip peptides from class II MHC proteins.
score: 0.81053257, Nature chemical biology, 2006, De Wall, Stephen L et. al.
Cell-penetrating autoantibody induces caspase-mediated apoptosis through catalytic hydrolysis of DNA
score: 0.81043567, Bioorganic & Medicinal Chemistry, 2007, Lee, Eun-Jung et. al.
Synthesis and biological activity of ras farnesyl protein transferase inhibitors. Tetrapeptide analogs with amino methyl and carbon linkages
score: 0.81037944, Bioorganic & Medicinal Chemistry, 1994, Wai, John S. et. al.
Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells
score: 0.81031538, Bioorganic & Medicinal Chemistry, 2004, Kubo, Isao; Nihei, Ken-ichi; Tsujimoto, Kazuo
Synthesis and hybridization properties of an acyclic achiral phosphonate DNA analogue
score: 0.81006247, Bioorganic & Medicinal Chemistry, 1998, Kehler, Jan; Henriksen, Ulla; Vejbjerg, Helene; Dahl, Otto
Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives
score: 0.81003261, European Journal of Medicinal Chemistry, 2012, Gontijo, Vanessa Silva et. al.
Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives
score: 0.81003261, European Journal of Medicinal Chemistry, 2012, Gontijo, Vanessa Silva et. al.
A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis.
score: 0.80950221, Nature chemical biology, 2012, Bretschneider, Tom et. al.
2,2′-Bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced Peripheral blood mononuclear cells
score: 0.80942542, European Journal of Medicinal Chemistry, 2010, Rupesh, K.R. et. al.
Synthesis of novel fluorescent-labelled dinucleoside polyphosphates
score: 0.80911523, Bioorganic & Medicinal Chemistry Letters, 2004, Wright, Michael; Miller, Andrew D.
Structural and functional characterization of a synthetically modified OmpG
score: 0.80908646, Bioorganic & Medicinal Chemistry, 2010, Grosse, Wolfgang et. al.
Novel polysulfated galactose-derivatized dendrimers as binding antagonists of human immunodeficiency virus type 1 infection.
score: 0.80869222, Antimicrobial agents and chemotherapy, 2004, Kensinger, Richard D et. al.
Detailed structure–activity relationship of indolecarboxamides as H4 receptor ligands
score: 0.80833743, European Journal of Medicinal Chemistry, 2012, Engelhardt, Harald et. al.
Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1.
score: 0.80831661, Antimicrobial agents and chemotherapy, 2005, Moser, Michael J et. al.
Synthesis of quaternised 2-aminopyrimido[4,5- d]pyrimidin-4(3 H)-ones and their biological activity with dihydrofolate reductase
score: 0.80825243, European Journal of Medicinal Chemistry, 2003, Gebauer, Markus G; McKinlay, Carolyn; Gready, Jill E
Sodium etiobilirubin-IVγ-C10-sulfonate: a highly solvated bile pigment structure containing two different non-ridge-tile conformers in the unit cell
score: 0.80822702, Bioorganic & Medicinal Chemistry Letters, 2001, Senge, Mathias O; Ma, Jin Shi; McDonagh, Antony F
Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility—III
score: 0.80821463, Bioorganic & Medicinal Chemistry, 1995, Sasho, Setsuya et. al.
Synthesis of oligonucleotide 2′-conjugates via amide bond formation in solution
score: 0.80793922, Bioorganic & Medicinal Chemistry Letters, 2004, Kachalova, Anna V. et. al.
Studies on interaction of an intramolecular charge transfer fluorescence probe: 4′-Dimethylamino-2,5-dihydroxychalcone with DNA
score: 0.80777415, Bioorganic & Medicinal Chemistry, 2005, Xu, Zhicheng; Bai, Guan; Dong, Chuan
Mild and efficient oxidation of alcohols with sodium periodate catalyzed by polystyrene-bound Mn(III)porphyrin
score: 0.80690603, Bioorganic & Medicinal Chemistry, 2005, Moghadam, Majid et. al.
Fluorination of mammalian cell surfaces via the sialic acid biosynthetic pathway
score: 0.80678424, Bioorganic & Medicinal Chemistry Letters, 2008, Dafik, Laila; d’Alarcao, Marc; Kumar, Krishna
Investigation of the biological mode of action of clerocidin using whole cell assays
score: 0.80662862, Bioorganic & Medicinal Chemistry, 2001, Jamora, Colin et. al.
Building a common feature hypothesis for thymidylate synthase inhibition
score: 0.80643028, Bioorganic & Medicinal Chemistry, 2000, Kim, Seung-Gull et. al.
An efficient chemoenzymatic route to the antidepressants ( R)-fluoxetine and ( R)-tomoxetine
score: 0.80606644, Bioorganic & Medicinal Chemistry, 1996, Bracher, Franz; Litz, Thomas
Cytokine expression in the colonic mucosa of human immunodeficiency virus-infected individuals before and during 9 months of antiretroviral therapy.
score: 0.80604799, Antimicrobial agents and chemotherapy, 2008, Schulbin, Hubert et. al.
Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity
score: 0.80600196, Bioorganic & Medicinal Chemistry, 2004, Cocco, Maria T. et. al.
Structure–function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin
score: 0.80591733, Bioorganic & Medicinal Chemistry, 2005, Trouillas, Patrick et. al.
Biosynthesis: a twist in the tail.
score: 0.80590307, Nature chemical biology, 2011, Weissman, Kira J
Human serum transferrin cobalt complex: Stability and cellular uptake of cobalt
score: 0.80589811, Bioorganic & Medicinal Chemistry, 2005, Smith, T.A.D.
Experimental and Calculated Shift in p K a upon Binding of Phosphotyrosine Peptide to the SH2 Domain of p56 lck
score: 0.80544285, Bioorganic & Medicinal Chemistry, 2002, de Mol, Nico J.; Gillies, Malcolm B.; Fischer, Marcel J.E.
Synthesis and biological evaluation of methoxyphenyl porphyrin derivatives as potential photodynamic agents
score: 0.80527791, Bioorganic & Medicinal Chemistry, 2001, Elisa Milanesio, M et. al.
Synthesis of linked triple helical DNAs possessing high affinity to triple helical DNA binding protein
score: 0.80508769, Bioorganic & Medicinal Chemistry Letters, 2006, Shibata, Aya et. al.
QSAR studies for the inhibition of the transmembrane isozymes XII and XIV of human carbonic anhydrase with a series of sulfonamides
score: 0.80470783, Bioorganic & Medicinal Chemistry, 2007, Tarko, Laszlo; Supuran, Claudiu T.
Radiosynthesis of [ 18F]Lu29-024: A potential PET ligand for brain imaging of the serotonergic 5-HT 2 receptor
score: 0.80455861, Bioorganic & Medicinal Chemistry, 2000, Sobrio, Franck et. al.
Design, synthesis and antibacterial activity of novel 1,3-thiazolidine pyrimidine nucleoside analogues
score: 0.80442174, Bioorganic & Medicinal Chemistry, 2006, Sriharsha, Shimoga Nagaraj et. al.
Stereochemical determination and bioactivity assessment of ( S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis
score: 0.80441044, Bioorganic & Medicinal Chemistry, 2005, Cichewicz, Robert H. et. al.
Preferential binding to DNA sequences of peptides related to a novel XPRK motif
score: 0.80402565, Bioorganic & Medicinal Chemistry, 2003, Yang, Chia-Hung et. al.
Helenanolide type sesquiterpene lactones. Part 5: The role of glutathione addition under physiological conditions
score: 0.80398071, Bioorganic & Medicinal Chemistry, 1999, Schmidt, Thomas J et. al.
Design of a pyrene-containing fluorescence probe for labeling of RNA poly(A) tracts
score: 0.80363527, Bioorganic & Medicinal Chemistry, 2008, Tanaka, Kazuo; Okamoto, Akimitsu
Blue CrO 5 assay: A novel spectrophotometric method for the evaluation of the antioxidant and oxidant capacity of various biological substances
score: 0.80354783, European Journal of Medicinal Chemistry, 2009, Charalampidis, Pavlos S. et. al.
Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations.
score: 0.80354037, Antimicrobial agents and chemotherapy, 2005, Smith, Anthony J et. al.
QSAR of the testosterone binding globulin affinity by means of correlation weighting of local invariants of the graph of atomic orbitals
score: 0.80350615, Bioorganic & Medicinal Chemistry, 2005, Raska, Ivan; Toropov, Andrey
A highly efficient preparation of neoglycoconjugate vaccines using subcarriers that bear clustered carbohydrate antigens
score: 0.80315312, Bioorganic & Medicinal Chemistry Letters, 1999, Zhang, Jian; Kováč, Pavol
Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines
score: 0.80314417, Bioorganic & Medicinal Chemistry, 2012, Venkatesha, Shivaprasad H. et. al.
Synthesis and β-lactamase inhibitory activity of 6-fluoropenicillanic acids
score: 0.80299525, Bioorganic & Medicinal Chemistry, 1993, Danelon, Gerardo O. et. al.
High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation.
score: 0.80279297, Antimicrobial agents and chemotherapy, 2007, Pelat, Thibaut et. al.
Control of reaction chemoselectivity with a circular DNA template in the ligation of short oligodeoxyribonucleotides
score: 0.80274191, Bioorganic & Medicinal Chemistry, 2001, Selvasekaran, Janardhanam; Turnbull, Kenneth D
Mechanism of degradation of 2′-deoxycytidine by formamide: Implications for chemical DNA sequencing procedures
score: 0.8027018, Bioorganic & Medicinal Chemistry, 1997, Saladino, Raffaele et. al.
In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model
score: 0.80262143, European Journal of Medicinal Chemistry, 2010, Raman, N. et. al.
The 3-methylaspartase reaction probed using 2H- and 15N-Isotope effects for three substrates: a flip from a concerted to a carbocationic amino-Enzyme elimination mechanism upon changing the C-3 stereochemistry in the substrate from R to S
score: 0.80234897, Bioorganic & Medicinal Chemistry, 1999, Gani, David et. al.
Active site geometry of porcine pancreatic lipase: an interesting switchover from Jones' to Seebach's model
score: 0.80205925, Bioorganic & Medicinal Chemistry Letters, 2001, Basak, Amit et. al.
Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(Tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)
score: 0.80192351, European Journal of Medicinal Chemistry, 2012, Kaluđerović, Goran N. et. al.
Spectrum of pncA mutations in multidrug-resistant Mycobacterium tuberculosis isolates obtained in Latvia.
score: 0.80188104, Antimicrobial agents and chemotherapy, 2004, Tracevska, Tatjana et. al.
Regioselective hydrolysis of pentaacetyl catechin and epicatechin by porcine liver esterase
score: 0.80184326, Bioorganic & Medicinal Chemistry Letters, 2003, Basak, Amit; Mandal, Subrata; Bandyopadhyay, Saibal
The specificity of Prolyl Endopeptidase from Flavobacterium meningoseptum: mapping the S′ subsites by positional scanning via acyl transfer
score: 0.80180947, Bioorganic & Medicinal Chemistry, 1998, Bordusa, Frank; Jakubke, Hans-Dieter
Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease
score: 0.80130273, European Journal of Medicinal Chemistry, 2005, Smith, Daniel T. et. al.
Synthesis of the fatty sterol bound protein for a new sterol antibody
score: 0.80113944, Bioorganic & Medicinal Chemistry Letters, 2000, Kim, Byung Ju et. al.
In vitro selection of DNA aptamers that bind l-tyrosinamide
score: 0.80101227, Bioorganic & Medicinal Chemistry, 2001, Vianini, Elena; Palumbo, Manlio; Gatto, Barbara
para-substituted N-Nitroso- N-oxybenzenamine ammonium salts: a new class of redox-sensitive nitric oxide releasing compounds
score: 0.80062112, Bioorganic & Medicinal Chemistry, 2000, McGill, Andrea D et. al.
The Journey to the Discovery of Boceprevir-1:An NS3–NS4 HCV Protease Inhibitor for the Treatment of Chronic Hepatitis C
score: 0.80027861, Progress in Medicinal Chemistry, 2010, Chen, Kevin X.; Njoroge, F. George
Acetamidoquinone and acetamidohydroxy derivatives as inhibitors for both dihydroxyacetamido epoxidase and dehydrogenase
score: 0.7998978, Bioorganic & Medicinal Chemistry, 2002, Whiteley, Chris G.
A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues
score: 0.79975488, Bioorganic & Medicinal Chemistry, 2006, Stadelmaier, A. et. al.
Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function
score: 0.79961451, Nature chemical biology, 2010, Kwiatkowski, Nicholas et. al.
Genetic engineering of Escherichia coli for the production of precorrin-3 in vivo and in vitro
score: 0.79939434, Bioorganic & Medicinal Chemistry, 1999, Roessner, Charles A.; Park, Jeong-Ho; Scott, A.Ian
Synthesis and investigation of glycosylated mono- and diarylporphyrins for photodynamic therapy
score: 0.7989847, Bioorganic & Medicinal Chemistry, 1999, Schell, Christian; Hombrecher, Hermann K.
Antiproliferative activities of iron and platinum conjugates of salicylaldehyde semi-/thiosemicarbazones against C6 glioma cells
score: 0.79890174, European Journal of Medicinal Chemistry, 2005, Patole, J.; Padhye, S.; Moodbidri, M.S.; Shirsat, N.
Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs
score: 0.7988985, European Journal of Medicinal Chemistry, 2012, Panda, Parthasarathi et. al.
Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs
score: 0.7988985, European Journal of Medicinal Chemistry, 2012, Panda, Parthasarathi et. al.
Sequence-specific Methyltransferase-Induced Labelling (SMILing) of plasmid DNA for studying cell transfection
score: 0.7987516, Bioorganic & Medicinal Chemistry, 2008, Schmidt, Falk H.-G. et. al.
Synthesis and in vitro characterization of trans- and cis-[18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor
score: 0.79856362, European Journal of Medicinal Chemistry, 2012, Koudih, Radouane et. al.
Stereoselective allyl transfer to chiral α-methoxycarbaldehydes: A model study related to the C-9/C-15 fragment of geldanamycin
score: 0.79852128, Bioorganic & Medicinal Chemistry, 2006, Horneff, Tony et. al.
Enzymes in the synthesis of bioactive compounds
score: 0.79837484, Bioorganic & Medicinal Chemistry, 2004, Garcı́a-Junceda, Eduardo et. al.
Macrolide resistance conferred by base substitutions in 23S rRNA.
score: 0.79804547, Antimicrobial agents and chemotherapy, 2001, Vester, B; Douthwaite, S
Salivary antimicrobial peptide expression and dental caries experience in children.
score: 0.7979811, Antimicrobial agents and chemotherapy, 2005, Tao, Renchuan et. al.
Development of agents for reinforcement of fluorescence on near-infrared ray excitation for immunohistological staining
score: 0.7978837, Bioorganic & Medicinal Chemistry, 1998, Ito, Susumu et. al.
Modulation of the skeletal muscle Ca 2+ release channel/ryanodine receptor by adenosine and its metabolites: a structure–activity approach
score: 0.79783924, Bioorganic & Medicinal Chemistry, 2003, Butanda-Ochoa, Armando et. al.
Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase
score: 0.79755303, Bioorganic & Medicinal Chemistry Letters, 2013, Zeng, Jia et. al.
Effects of the hydrophobicity of taxoids on their interaction with tubulin
score: 0.79750272, Bioorganic & Medicinal Chemistry, 2000, Guénard, Daniel et. al.
Synthesis of mycothiol, 1D-1- O-(2-[ N-acetyl- l-cysteinyl]amino-2-deoxy-α- d-glucopyranosyl)- myo-inositol, principal low molecular mass thiol in the actinomycetes
score: 0.79672001, Bioorganic & Medicinal Chemistry, 2002, Jardine, M.Anwar et. al.
Interaction of tRNA-Derivatives and Oligonucleotide Primers with AZT-Resistant Mutants of HIV-1 Reverse Transcriptase
score: 0.79657553, Bioorganic & Medicinal Chemistry, 1998, Zakharova, Olga D. et. al.
Inhibition of polyamine synthesis arrests trichomonad growth and induces destruction of hydrogenosomes.
score: 0.79638279, Antimicrobial agents and chemotherapy, 1999, Reis, I A et. al.
Synthesis, antibacterial and antifungal activity of some new thiazolylhydrazone derivatives containing 3-substituted cyclobutane ring
score: 0.7962535, European Journal of Medicinal Chemistry, 2006, Cukurovali, Alaaddin et. al.
The early oxidative biodegradation steps of residual kraft lignin models with laccase
score: 0.79622385, Bioorganic & Medicinal Chemistry, 1998, Crestini, Claudia; Argyropoulos, Dimitris S.
Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX
score: 0.79586687, Bioorganic & Medicinal Chemistry, 2004, Mehedi Masud, Mohammad et. al.
Chemical biology at the Broad Institute.
score: 0.79585931, Nature chemical biology, 2007, Kotz, Joanne
Theoretical simulation of the electronic circular dichroism spectrum of calicheamicin
score: 0.79560071, Bioorganic & Medicinal Chemistry, 2005, Giorgio, Egidio et. al.
Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers.
score: 0.79537989, Antimicrobial agents and chemotherapy, 1998, Hsu, A et. al.
Polystyrene-bound Mn(T4PyP): A highly efficient and reusable catalyst for biomimetic oxidative decarboxylation of carboxylic acids with sodium periodate
score: 0.79502768, Bioorganic & Medicinal Chemistry, 2009, Moghadam, Majid et. al.
Biotechnology and applied genomics for health: initiatives of the European Union
score: 0.79498631, European Journal of Medicinal Chemistry, 2003, Aguilar, Alfredo et. al.
Synthesis and inhibition of PGE 2 production of 6,8-disubstituted chrysin derivatives
score: 0.79497267, European Journal of Medicinal Chemistry, 2005, Park, Haeil; Dao, Tran Thanh; Kim, Hyun Pyo
Plasmid relaxation induced by copper metalated diglycine conjugates under heterogeneous reaction conditions
score: 0.7947764, Bioorganic & Medicinal Chemistry Letters, 2003, Madhavaiah, C; Verma, Sandeep
Corrigendum to “Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores” [Bioorg. Med. Chem. 17 (2009) 3934]
score: 0.79470896, Bioorganic & Medicinal Chemistry, 2010, Kotian, Pravin L. et. al.
A fungal ketoreductase domain that displays substrate-dependent stereospecificity.
score: 0.79455065, Nature chemical biology, 2012, Zhou, Hui et. al.
Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques.
score: 0.79450051, Antimicrobial agents and chemotherapy, 2004, Van Rompay, Koen K A et. al.
Recognition of Bulged DNA by a Neocarzinostatin Product via an Induced Fit Mechanism
score: 0.79448343, Bioorganic & Medicinal Chemistry, 2002, Yang, Catherine F. et. al.
Omp35, a new Enterobacter aerogenes porin involved in selective susceptibility to cephalosporins.
score: 0.79446588, Antimicrobial agents and chemotherapy, 2004, Bornet, Charléric et. al.
Photo-induced anticancer activity of polypyridyl platinum(II) complexes
score: 0.79430936, European Journal of Medicinal Chemistry, 2012, Maity, Basudev et. al.
Photo-induced anticancer activity of polypyridyl platinum(II) complexes
score: 0.79430936, European Journal of Medicinal Chemistry, 2012, Maity, Basudev et. al.
Synthesis and antitumour activity of 4-hydroxy-2-pyridone derivatives
score: 0.79413764, European Journal of Medicinal Chemistry, 2000, Cocco, Maria T; Congiu, Cenzo; Onnis, Valentina
5-Phenyl substituted 1-methyl-2-pyridones and 4′-substituted biphenyl-4-carboxylic acids. synthesis and evaluation as inhibitors of steroid-5α-reductase type 1 and 2
score: 0.7941167, Bioorganic & Medicinal Chemistry, 2002, Picard, Franck; Schulz, Tobias; Hartmann, Rolf W.
Truncated phosphonated C-1’-branched N,O-nucleosides: A new class of antiviral agents
score: 0.79403181, Bioorganic & Medicinal Chemistry, 2012, Romeo, Roberto et. al.
Ultraviolet spectroscopy of anticonvulsant enaminones
score: 0.79399222, Bioorganic & Medicinal Chemistry, 2002, Edafiogho, I.O et. al.
Cleavage of β-lactone ring by serine protease. Mechanistic implications
score: 0.7938521, Bioorganic & Medicinal Chemistry, 2002, Kim, Dong H. et. al.
Antimicrobial and immunologic activities of clarithromycin in a murine model of Mycoplasma pneumoniae-induced pneumonia.
score: 0.79343125, Antimicrobial agents and chemotherapy, 2003, Hardy, Robert D et. al.
Antibacterial Activity of Joint Fluid in Cemented Total-Knee Arthroplasty: an In Vivo Comparative Study of Polymethylmethacrylate with and without Antibiotic Loading.
score: 0.79333779, Antimicrobial agents and chemotherapy, 2012, Ueng, Steve W N et. al.
Intercalation of ethidium and analogues with nucleic acids: a molecular orbital study
score: 0.79319836, Bioorganic & Medicinal Chemistry, 1997, Patterson, Steven E.; Coxon, James M.; Strekowski, Lucjan
Synthesis of cytotoxic fluorinated quassinoids
score: 0.79317268, Bioorganic & Medicinal Chemistry, 1997, Ohno, Nobuhiro et. al.
Synthesis of cytotoxic fluorinated quassinoids
score: 0.79317268, Bioorganic & Medicinal Chemistry, 1997, Ohno, Nobuhiro et. al.
Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors
score: 0.79293273, European Journal of Medicinal Chemistry, 2006, Bonechi, C. et. al.
High-throughput crystallography for lead discovery in drug design.
score: 0.79283714, Nature reviews. Drug discovery, 2002, Blundell, Tom L; Jhoti, Harren; Abell, Chris
Rebeccamycin analogues as anti-cancer agents
score: 0.79275637, European Journal of Medicinal Chemistry, 2003, Prudhomme, Michelle
Deoxysarpagine Hydroxylase — A Novel Enzyme Closing a Short Side Pathway of Alkaloid Biosynthesis in Rauvolfia
score: 0.79265007, Bioorganic & Medicinal Chemistry, 2002, Yu, Bingwu; Ruppert, Martin; Stöckigt, Joachim
Synthesis, characterization, and in vitro and in vivo evaluation of a novel pectin–adriamycin conjugate
score: 0.79264746, Bioorganic & Medicinal Chemistry, 2010, Tang, Xiao-Hai et. al.
In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone
score: 0.79243927, European Journal of Medicinal Chemistry, 2006, Nawrot-Modranka, Jolanta; Nawrot, Ewa; Graczyk, Julita
Synthesis, characterization and cytotoxicity of iodo-bridged binuclear platinum(II) complexes
score: 0.79174227, European Journal of Medicinal Chemistry, 2010, Zhang, Jinchao et. al.
Computational Analysis of Structure–Activity Relationships
score: 0.79143444, Progress in Medicinal Chemistry, 2010, Gedeck, Peter; Kramer, Christian; Ertl, Peter
Synthesis of C 2-symmetric guanidino-sugars as potent inhibitors of glycosidases
score: 0.79116692, Bioorganic & Medicinal Chemistry, 2000, Le Merrer, Yves et. al.
Ultrasensitive assay of azithromycin in medicine and bio-Fluids based on its enhanced luminol–H 2O 2 chemiluminescence reaction using flow injection technique
score: 0.79111137, Bioorganic & Medicinal Chemistry, 2003, Song, Zhenghua; Wang, Changna
An elegant synthesis of Zetaclausenamide
score: 0.79091011, European Journal of Medicinal Chemistry, 2008, Ma, Nianchun; Wu, Kemei; Huang, Liang
Stability of DNA/Td3717 complexes for gene transfection, defined by the size and polydispersity of the complex
score: 0.7908086, Bioorganic & Medicinal Chemistry, 2009, Kuriyama, Shinichi et. al.
New highly potent dipeptidic growth hormone secretagogues with low molecular weight
score: 0.79075945, European Journal of Medicinal Chemistry, 2000, Peschke, Bernd et. al.
Density functional and ab initio studies on N-acetyl-duocarmycin SA: insight into its DNA interaction properties
score: 0.790731, Bioorganic & Medicinal Chemistry, 2000, Kirschner, Karl N. et. al.
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
score: 0.79068416, Nature chemical biology, 2011, Deng, Xianming et. al.
The substrate specificity of tocopherol cyclase
score: 0.79068013, Bioorganic & Medicinal Chemistry, 1996, Stocker, Achim et. al.
Interaction between morphine and lysine
score: 0.79060026, Bioorganic & Medicinal Chemistry Letters, 2001, Nakai, Sachiko; Yoneda, Fumio
Rates of thrombin acylation and deacylation upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylating agents
score: 0.79057702, Bioorganic & Medicinal Chemistry, 1995, Brown, Audra D.; Powers, James C.
Tethered naphthalene diimide intercalators enhance DNA triplex stability
score: 0.79048011, Bioorganic & Medicinal Chemistry, 2001, Gianolio, Diego A.; McLaughlin, Larry W.
Hexofuranosyl thymidines inserted into oligodeoxynucleotides via their two exocyclic hydroxy groups. Oligo synthesis and RNase H activity
score: 0.79040676, Bioorganic & Medicinal Chemistry, 2004, Filichev, Vyacheslav V.; Vester, Birte; Pedersen, Erik B.
Role of glutamate 243 in the active site of 2-deoxy- scyllo-inosose synthase from Bacillus circulans
score: 0.79038811, Bioorganic & Medicinal Chemistry, 2007, Hirayama, Toshifumi et. al.
Design and evaluation of “3 + 1” mixed ligand oxorhenium and oxotechnetium complexes bearing a nitroaromatic group with potential application in nuclear medicine oncology
score: 0.79000678, European Journal of Medicinal Chemistry, 2006, Giglio, J. et. al.
Efficient intermittent rifapentine-moxifloxacin-containing short-course regimen for treatment of tuberculosis in mice.
score: 0.78963379, Antimicrobial agents and chemotherapy, 2005, Veziris, N et. al.
Interaction between polyamines and bacterial outer membranes as investigated with ion-selective electrodes.
score: 0.78960077, Antimicrobial agents and chemotherapy, 2002, Katsu, Takashi; Nakagawa, Hideki; Yasuda, Keiko
Spectroscopic studies of the interaction between hypocrellin B and human serum albumin
score: 0.78958401, Bioorganic & Medicinal Chemistry, 2006, Zhao, Baozhong et. al.
Hemisynthesis and antiproliferative properties of mono-[O-(14-benzoylaconine-8-yl)]esters and bis-[O-(14-benzoylaconine-8-yl)]esters
score: 0.78956772, European Journal of Medicinal Chemistry, 2012, Chodoeva, Ainura et. al.
Hemisynthesis and antiproliferative properties of mono-[O-(14-benzoylaconine-8-yl)]esters and bis-[O-(14-benzoylaconine-8-yl)]esters
score: 0.78956772, European Journal of Medicinal Chemistry, 2012, Chodoeva, Ainura et. al.
Fluoride excess in coccidioidomycosis patients receiving long-term antifungal therapy: an assessment of currently available triazoles.
score: 0.78906305, Antimicrobial agents and chemotherapy, 2012, Thompson, George R et. al.
Electrochemical release from gold–thiolate electrodes for controlled insertion of ion channels into bilayer membranes
score: 0.78889354, Bioorganic & Medicinal Chemistry, 2004, Buchmann, M.B; Fyles, T.M; Sutherland, T
Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo.
score: 0.78878417, Antimicrobial agents and chemotherapy, 2012, Ho, Kitty Ka Kit et. al.
Synthesis and QSAR studies of novel triazole compounds containing thioamide as potential antifungal agents
score: 0.78812867, Bioorganic & Medicinal Chemistry, 2006, Wei, Qing-Li et. al.
Kinase inhibitors modulate huntingtin cell localization and toxicity.
score: 0.78781415, Nature chemical biology, 2011, Atwal, Randy Singh et. al.
Side-chain assisted ligation in protein synthesis
score: 0.78766944, Bioorganic & Medicinal Chemistry Letters, 2009, Ajish Kumar, K.S. et. al.
Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.
score: 0.78760428, Nature chemical biology, 2007, Khidekel, Nelly et. al.
Carbonic anhydrase activators – Part 21 # # See Ref. [1] . Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties
score: 0.78755633, European Journal of Medicinal Chemistry, 2000, Scozzafava, Andrea; Supuran, Claudiu T.
Chemotactic peptides: fMLF-OMe analogues incorporating proline–methionine chimeras as N-terminal residue
score: 0.78728239, Bioorganic & Medicinal Chemistry, 2006, Mollica, Adriano et. al.
Synthesis and biological investigations of [ 18F]MR18445, a 5-HT 3 receptor partial agonist
score: 0.78725968, Bioorganic & Medicinal Chemistry, 1998, Katounina, Tatiana et. al.
In vitro antimycobacterial activity of 5-chloropyrazinamide.
score: 0.78653507, Antimicrobial agents and chemotherapy, 1998, Cynamon, M H; Speirs, R J; Welch, J T
Synthesis and evaluation as glycosidase inhibitors of 2,5-imino- d-glucitol and 1,5-imino- d-mannitol related derivatives
score: 0.78639496, Bioorganic & Medicinal Chemistry, 2000, McCort, Isabelle et. al.
In vitro monitoring sub-Nanogram amounts analgin in human urine by its inhibitory of the luminol-Periodate chemiluminescence reaction using reagent immobilization release technique
score: 0.78605239, Bioorganic & Medicinal Chemistry, 2002, Song, Zhenghua; Zhang, Ni
Preparations of heterospirostanols and their pharmacological activities
score: 0.78600925, European Journal of Medicinal Chemistry, 2002, Quan, Hang-Ji et. al.
Radiolabeling of paclitaxel with electrophilic 123I
score: 0.78599075, Bioorganic & Medicinal Chemistry, 2000, Roh, Eun Joo et. al.
Novel hyaluronic acid–methotrexate conjugates for osteoarthritis treatment
score: 0.7857337, Bioorganic & Medicinal Chemistry, 2009, Homma, Akie et. al.
New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity
score: 0.78561831, Scientia Pharmaceutica, 2010, Patel, Navin B.; Shaikh, Faiyazalam M.
Synthesis, antioxidant properties, biological activity and molecular modelling of a series of chalcogen analogues of the 5-lipoxygenase inhibitor DuP 654
score: 0.78533378, Bioorganic & Medicinal Chemistry, 1995, Engman, Lars et. al.
Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors
score: 0.78512004, Bioorganic & Medicinal Chemistry, 2003, Jiang, De-Jian et. al.
A single circularly permuted GFP sensor for inositol-1,3,4,5-tetrakisphosphate based on a split PH domain
score: 0.78509334, Bioorganic & Medicinal Chemistry, 2009, Sakaguchi, Reiko et. al.
Synthesis, structure, electrochemistry and spectral characterization of ( d-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice
score: 0.78502901, European Journal of Medicinal Chemistry, 2010, Sathisha, M.P. et. al.
3-Bromo- 4-(1 H-3-indolyl)-2,5-dihydro-1 H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances
score: 0.78469712, European Journal of Medicinal Chemistry, 2006, Mahboobi, Siavosh et. al.
Synthesis and QSAR study of the anticancer activity of some novel indane carbocyclic nucleosides
score: 0.78467211, Bioorganic & Medicinal Chemistry, 2003, Yao, S.-W et. al.
Structural study on silkworm eclosion hormone fragment (1–34) in solution by proton nuclear magnetic resonance spectroscopy
score: 0.78402671, Bioorganic & Medicinal Chemistry, 1998, Nosaka, Atsuko Y et. al.
Syntheses and immunomodulatory activity of 3- O-[2′-hydroxy-3′- N, N-disubstituted aminopropan-1′-yl]-α- d-glucofuranoses
score: 0.78374447, European Journal of Medicinal Chemistry, 2001, Khan, Abdul Rehman et. al.
The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and ε-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli.
score: 0.78328345, Antimicrobial agents and chemotherapy, 2012, Noll, Katia Sutyak et. al.
Activities of antimicrobial agents against intracellular pneumococci.
score: 0.78325202, Antimicrobial agents and chemotherapy, 2000, Mandell, G L; Coleman, E J
GFP-linked zinc finger protein sp1
score: 0.78260509, Bioorganic & Medicinal Chemistry, 2003, Matsushita, Keizo; Sugiura, Yukio
Product quality of parenteral vancomycin products in the United States.
score: 0.78250418, Antimicrobial agents and chemotherapy, 2012, Nambiar, S et. al.
An engineered chorismate mutase with allosteric regulation
score: 0.78212647, Bioorganic & Medicinal Chemistry, 2003, Zhang, Sheng; Wilson, David B; Ganem, Bruce
Anti-genotoxic hydrazide from Crinum defixum
score: 0.7820277, European Journal of Medicinal Chemistry, 2009, Bordoloi, Manobjyoti et. al.
A study on the perturbation of model lipid membranes by phenoxazines
score: 0.7817591, Bioorganic & Medicinal Chemistry, 2006, Hendrich, Andrzej B. et. al.
Targeting the tat-binding site of bovine immunodeficiency virus TAR RNA with a shape-selective rhodium complex
score: 0.78170081, Bioorganic & Medicinal Chemistry, 1997, Ai Ching Lim, ; Barton, Jacqueline K.
Synthesis and antifungal potential of Co(II) complexes of 1-(2′-hydroxyphenyl) ethylideneanilines
score: 0.78151584, European Journal of Medicinal Chemistry, 2006, Hothi, H.S.; Makkar, Anju; Sharma, J.R.; Manrao, M.R.
Synthesis, cytotoxicity and DNA-binding levels of new type binuclear platinum(II) complexes
score: 0.78150643, European Journal of Medicinal Chemistry, 2009, Zhang, Jinchao et. al.
Context dependent RNA-RNA recognition in a three-dimensional model of the 16S rRNA core
score: 0.78143726, Bioorganic & Medicinal Chemistry, 1997, Masquida, Benoît; Felden, Brice; Westhof, Eric
Investigation into new anticonvulsant derivatives of α-substituted N-benzylamides of γ-hydroxy- and γ-acetoxybutyric acid. Part 5: Search for new anticonvulsant compounds
score: 0.78133184, Bioorganic & Medicinal Chemistry, 2004, Malawska, Barbara et. al.
Pharmaco-toxicological study of diterpenoids
score: 0.78125932, Bioorganic & Medicinal Chemistry, 2003, Delporte, Carla et. al.
Celebrating synthesis.
score: 0.7804601, Nature chemical biology, 2011,
NMR studies of the post-activated neocarzinostatin chromophore-DNA complex. Conformational changes induced in drug and DNA
score: 0.78042347, Bioorganic & Medicinal Chemistry, 1995, Gao, Xiaolian et. al.
Determination of a sugar chain and its linkage site on a glycoprotein TIME-EA4 from silkworm diapause eggs by means of LC-ESI-Q-TOF-MS and MS/MS
score: 0.780415, Bioorganic & Medicinal Chemistry, 2002, Kurahashi, Takuya et. al.
Rat liver microsomal enzyme catalyzed oxidation of 4-phenyl- trans-1-(2-phenylcyclopropyl)-1,2,3,6-tetrahydropyridine
score: 0.78014979, Bioorganic & Medicinal Chemistry, 2001, Kuttab, Simon; Shang, Jackie; Castagnoli, Neal
Structure–activity relationship of HIV-1 protease inhibitors containing AHPBA. Part III: modification of P 2 site
score: 0.78007185, Bioorganic & Medicinal Chemistry, 1998, Takashiro, Eiji et. al.
Asymmetric hydroformylation with highly crosslinked polystyrene-supported ( R,S)-BINAPHOS–Rh(I) complexes: the effect of immobilization position
score: 0.77973335, Bioorganic & Medicinal Chemistry Letters, 2002, Shibahara, Fumitoshi et. al.
The synthesis of novel HIV-protease inhibitors
score: 0.77969234, Bioorganic & Medicinal Chemistry, 1994, Girijavallabhan, Viyyoor M. et. al.
Synthesis and cytotoxic effect of 1,3-dihydroxy-9,10-anthraquinone derivatives
score: 0.77967408, European Journal of Medicinal Chemistry, 2000, Wei, Bai-Luh et. al.
Conformational aspects of inhibitor design: enzyme–substrate interactions in the transition state
score: 0.77955778, Bioorganic & Medicinal Chemistry, 1999, Wolfenden, Richard
New ventures in the chemistry of avermectins
score: 0.7794032, Bioorganic & Medicinal Chemistry, 2009, Pitterna, Thomas et. al.
Thiol-dependent DNA cleavage by 3 H-1,2-benzodithiol-3-one 1,1-dioxide
score: 0.77903212, Bioorganic & Medicinal Chemistry Letters, 2000, Breydo, Leonid; Gates, Kent S.
Importance of surface properties of affinity resin for capturing a target protein, Cyclooxygenase-1
score: 0.77882527, Bioorganic & Medicinal Chemistry, 2009, Mori, Tomoko; Kubo, Takuya; Kaya, Kunimitsu; Hosoya, Ken
Potential drug-like inhibitors of Group 1 influenza neuraminidase identified through computer-aided drug design
score: 0.77851924, Computational Biology and Chemistry, 2010, Durrant, Jacob D.; McCammon, J. Andrew
Safety, tolerance, and pharmacokinetics of a small unilamellar liposomal formulation of amphotericin B (AmBisome) in neutropenic patients.
score: 0.77851141, Antimicrobial agents and chemotherapy, 1998, Walsh, T J et. al.
The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells
score: 0.77806499, Bioorganic & Medicinal Chemistry, 2001, Heilmann, Jörg; Wasescha, Michael R.; Schmidt, Thomas J.
Comparison in antioxidant actionbetweenα-chitosan andβ-chitosan ata wide range of molecular weightandchitosan concentration
score: 0.77802752, Bioorganic & Medicinal Chemistry, 2012, Jung, Jooyeoun; Zhao, Yanyun
Two-step enzymatic selective synthesis of water-soluble ketoprofen–saccharide conjugates in organic media
score: 0.77795468, Bioorganic & Medicinal Chemistry, 2009, Wang, Hai-Yang et. al.
Multicomponent synthesis of novel amino acid–nucleobase chimeras: a versatile approach to PNA-monomers
score: 0.77777595, Bioorganic & Medicinal Chemistry, 2000, Maison, Wolfgang et. al.
DFT-based QSAR study of testosterone and its derivatives
score: 0.77723183, Bioorganic & Medicinal Chemistry, 2004, Singh, P.P; Srivastava, H.K; Pasha, F.A
Silica-Based Artificial Protease Exploiting Aldehyde Groups as Catalytic Elements
score: 0.77698035, Bioorganic & Medicinal Chemistry Letters, 2002, Kim, Hyunsook et. al.
Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA
score: 0.77666099, Bioorganic & Medicinal Chemistry, 2003, Yu, Dong et. al.
Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent.
score: 0.77641893, Antimicrobial agents and chemotherapy, 2005, Hunter, Howard N et. al.
Comparison of MRI properties between derivatized DTPA and DOTA gadolinium–dendrimer conjugates
score: 0.77638678, Bioorganic & Medicinal Chemistry, 2010, Nwe, K. et. al.
Change or be changed:Reflections of the workshop ‘Future in Medicinal Chemistry’
score: 0.77615486, Bioorganic & Medicinal Chemistry, 2012, Brenk, Ruth; Rauh, Daniel
Green fluorescent proteins are light-induced electron donors
score: 0.77591147, Nature chemical biology, 2009, Bogdanov, Alexey M. et. al.
Syntheses of C 18 dibenzocyclooctadiene lignan derivatives as anti-HBsAg and anti-HBeAg agents
score: 0.77590086, Bioorganic & Medicinal Chemistry, 2005, Kuo, Yao-Haur et. al.
Characterization of a DNA-Cleaving deoxyribozyme
score: 0.77587706, Bioorganic & Medicinal Chemistry, 2001, Carmi, Nir; Breaker, Ronald R.
Stereoselective synthesis of 2-amino-3-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
score: 0.77586021, Bioorganic & Medicinal Chemistry, 2002, Pedregal, Concepción; Prowse, William
Site-specific labeling of ‘second generation’ annexin V with 99mTc(CO) 3 for improved imaging of apoptosis in vivo
score: 0.77576642, Bioorganic & Medicinal Chemistry, 2010, De Saint-Hubert, Marijke et. al.
New imidazo[1,2- a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities
score: 0.77567728, Bioorganic & Medicinal Chemistry, 1999, Vitse, Olivier et. al.
Phenolic acid derivatives with potential anticancer properties––a structure–activity relationship study. Part 1: Methyl, propyl and octyl esters of caffeic and gallic acids
score: 0.77544005, Bioorganic & Medicinal Chemistry, 2004, Fiuza, S.M. et. al.
Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight
score: 0.77513186, Bioorganic & Medicinal Chemistry, 2005, Billich, Andreas et. al.
Human DNA topoisomerase I inhibitory activities of synthetic polyamines
score: 0.77494071, Bioorganic & Medicinal Chemistry, 2001, Sukhanova, Alyona et. al.
Steroid-derived phospholipid scramblases induce exposure of phosphatidylserine on the surface of red blood cells
score: 0.77493696, Bioorganic & Medicinal Chemistry, 2005, DiVittorio, Kristy M. et. al.
Synthesis of nuclease-resistant siRNAs possessing universal overhangs
score: 0.7748381, Bioorganic & Medicinal Chemistry, 2009, Ueno, Yoshihito et. al.
Carbonic anhydrase inhibitors: Transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters
score: 0.77393153, Bioorganic & Medicinal Chemistry, 2006, Vullo, Daniela et. al.
Synthesis of 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives as potential antimicrobial agents
score: 0.77388034, European Journal of Medicinal Chemistry, 2003, Rameshkumar, Natesh et. al.
A phosphatidylinositol 3,4,5-trisphosphate analogue with low serum protein-binding affinity
score: 0.77387157, Bioorganic & Medicinal Chemistry, 2001, Wang, Da-Sheng; Hsu, Ao-Lin; Chen, Ching-Shih
The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies
score: 0.7736401, Journal of Biomedical Science, 2011, Lu, Shin-Hua et. al.
Pharmacokinetics and distribution over the blood-brain barrier of zalcitabine (2',3'-dideoxycytidine) and BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine) in rats, studied by microdialysis.
score: 0.77359814, Antimicrobial agents and chemotherapy, 1998, Borg, N; Ståhle, L
The 1.76 Å Resolution Crystal Structure of Glycogen Phosphorylase b Complexed with Glucose, and CP320626, a Potential Antidiabetic Drug
score: 0.77339968, Bioorganic & Medicinal Chemistry, 2002, Oikonomakos, Nikos G et. al.
Rat brain guanosine binding site
score: 0.77248431, Bioorganic & Medicinal Chemistry, 2003, Traversa, Ugo et. al.
Theoretical investigation of (−)1-(Benzofuran-2-yl)-2-propylaminopentane [(−)-BPAP] as a hydroxyl radical scavenger
score: 0.77241134, Bioorganic & Medicinal Chemistry, 2001, Nakai, Sachiko; Yoneda, Fumio
Synthesis and anti-HIV activity of α-thiophenoxy-hydroxyethylamide derivatives
score: 0.77219911, European Journal of Medicinal Chemistry, 1999, Medou, Martial et. al.
β-Lactam synthon-interceded diastereoselective synthesis of functionalized octahydroindole-based molecular scaffolds and their in vitro cytotoxic evaluation
score: 0.77217218, European Journal of Medicinal Chemistry, 2012, Singh, Pardeep et. al.
Edible Myrciaria vexator fruits: Bioactive phenolics for potential COPD therapy
score: 0.77214692, Bioorganic & Medicinal Chemistry, 2012, Dastmalchi, Keyvan et. al.
Edible Myrciaria vexator fruits: Bioactive phenolics for potential COPD therapy
score: 0.77214692, Bioorganic & Medicinal Chemistry, 2012, Dastmalchi, Keyvan et. al.
Chemoinformatics: Recent advances at the interfaces between computer and chemical information sciences, chemistry, and drug discovery
score: 0.77213399, Bioorganic & Medicinal Chemistry, 2012, Bajorath, Jürgen
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition-I. Synthesis, structure-activity relationship, and evaluation of substituted (ω-phenyl-ω)-(3-pyridyl)alkenoic acids
score: 0.77161232, Bioorganic & Medicinal Chemistry, 1994, Takeuchi, Kumiko et. al.
Aryl ureas represent a new class of anti-trypanosomal agents
score: 0.77129267, Chemistry & Biology, 2000, Du, Xiaohui et. al.
Application of chemical cytochrome P-450 model systems to studies on drug metabolism—VIII. Novel metabolism of carboxylic acids via oxidative decarboxylation
score: 0.7710707, Bioorganic & Medicinal Chemistry, 1995, Komuro, Masakatsu; Higuchi, Tsunehiko; Hirobe, Masaaki
Modified glycopeptides related to cell wall peptidoglycan: conformational studies by NMR and molecular modelling
score: 0.77076753, Bioorganic & Medicinal Chemistry, 2003, Fehér, Krisztina et. al.
Large scale, liquid phase oligonucleotide synthesis by alkyl H-phosphonate approach
score: 0.7706206, Bioorganic & Medicinal Chemistry, 2000, Padiya, Kamlesh J.; Salunkhe, Manikrao M.
Strand displacement recognition of mixed adenine–cytosine sequences in double stranded DNA by thymine–Guanine PNA (Peptide nucleic acid)
score: 0.77047539, Bioorganic & Medicinal Chemistry, 2001, Nielsen, Peter E; Egholm, Michael
Nature Chemical Biology. In this issue.
score: 0.77030532, Nature chemical biology, 2008, Goodman, Catherine; Kotz, Joanne; Sercy, Kenneth
Synthesis and Biological Activity of Novel Acridinylidene and Benzylidene thiazolidinediones
score: 0.77009733, European Journal of Medicinal Chemistry, 2005, Mourão, R.H. et. al.
Combinatorial discovery process yields antimicrobial peptoids
score: 0.76993314, Bioorganic & Medicinal Chemistry, 1999, Ng, Simon et. al.
Perfecting probes.
score: 0.76977854, Nature chemical biology, 2009,
Catalytic nanomedicine: A new field in antitumor treatment using supported platinum nanoparticles. In vitro DNA degradation and in vivo tests with C6 animal model on Wistar rats
score: 0.76958268, European Journal of Medicinal Chemistry, 2010, López, T. et. al.
The tert-butoxyl radical mediated hydrogen atom transfer reactions of the Parkinsonian proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and selected tertiary amines
score: 0.76944129, Bioorganic & Medicinal Chemistry, 2008, Suleman, N. Kamrudin et. al.
Oxidative cleavage of plasmid bluescript by water-Soluble Mn-Porphyrins and artificial oxidants or molecular oxygen
score: 0.76915705, Bioorganic & Medicinal Chemistry, 2003, Banfi, Stefano et. al.
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase
score: 0.76915216, European Journal of Medicinal Chemistry, 2012, Breda, Ardala et. al.
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase
score: 0.76915216, European Journal of Medicinal Chemistry, 2012, Breda, Ardala et. al.
Controlled site-selective protein glycosylation for precise glycan structure–catalytic activity relationships
score: 0.76913061, Bioorganic & Medicinal Chemistry, 2000, Davis, Benjamin G; Lloyd, Richard C; Jones, J.Bryan
Synthesis and evaluation of a novel 68Ga-labeled DOTA-benzamide derivative for malignant melanoma imaging
score: 0.7688463, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Hee-Jung et. al.
Molecular mechanisms of primary resistance to flucytosine in Candida albicans.
score: 0.76869915, Antimicrobial agents and chemotherapy, 2004, Hope, William W et. al.
Preparation and antimicrobial behaviour of gemini fluorosurfactants
score: 0.76858584, European Journal of Medicinal Chemistry, 2003, Massi, Lionel et. al.
Kinase inhibitors: narrowing down the real targets.
score: 0.76839231, Nature chemical biology, 2010, Daub, Henrik
Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483
score: 0.76792351, Bioorganic & Medicinal Chemistry, 1999, Bonjoch, J. et. al.
Syntheses and bioactivities of macrocyclic paclitaxel bis-lactones
score: 0.76738502, Bioorganic & Medicinal Chemistry, 2004, Liu, Changhui et. al.
Spectroscopic detection of endovesiculation by large unilamellar phosphatidylcholine vesicles: effects of chlorpromazine, dibucaine, and safingol
score: 0.76724865, Bioorganic & Medicinal Chemistry, 1999, Tedesco, Maureen M; Matile, Stefan
Interaction of novel condensed triazine derivatives with central and peripheral type benzodiazepine receptors: synthesis, in vitro pharmacology and modelling
score: 0.76710768, European Journal of Medicinal Chemistry, 2006, Szárics, Éva et. al.
A new solid-phase support for oligonucleotide synthesis
score: 0.76707078, Bioorganic & Medicinal Chemistry Letters, 1999, Devivar, Rodrigo V. et. al.
Novel Lipase-Catalysed Highly Selective Acetylation Studies on d- Arabino- and d- Threo-polyhydroxyalkyltriazoles
score: 0.76696616, Bioorganic & Medicinal Chemistry, 2002, Prasad, Ashok K et. al.
Molecular dynamics of NPY Y 1 receptor activation
score: 0.76676499, Bioorganic & Medicinal Chemistry, 1999, Sylte, I. et. al.
Medicinal chemistry tools: making sense of HTS data
score: 0.76663292, European Journal of Medicinal Chemistry, 2006, Kolossov, Evgueni; Lemon, Andrew
Corrigendum to “Evaluation of delocalized lipophilic cationic dyes as delivery vehicles for photosensitizers to mitochondria” [Bioorg. Med. Chem. 17 (2009) 6631]
score: 0.76650476, Bioorganic & Medicinal Chemistry, 2010, Ngen, Ethel J.; Rajaputra, Pallavi; You, Youngjae
Structure–Function Relationship in a β-Sheet Peptide Inhibitor of E47 Dimerization and DNA Binding
score: 0.76616445, Bioorganic & Medicinal Chemistry, 1999, Ghosh, Indraneel; Issac, Roy; Chmielewski, Jean
A comparison between two polarizability parameters in chemical–biological interactions
score: 0.76555793, Bioorganic & Medicinal Chemistry, 2005, Verma, Rajeshwar P.; Hansch, Corwin
Oligo(3-hydroxybutanoate) conjugates with acetylsalicylic acid and their antitumour activity
score: 0.76545235, European Journal of Medicinal Chemistry, 2008, Juzwa, Maria et. al.
Synthesis of a Novel Class of Non-Peptide NK-2 Receptor Ligand, Derived from 1-Phenyl-3-pyrrol-1-ylindan-2-carboxamides
score: 0.76453139, Bioorganic & Medicinal Chemistry, 2002, Guillon, Jean et. al.
Properties of nicked and circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligodeoxynucleotides
score: 0.76408455, Bioorganic & Medicinal Chemistry, 1998, Yamakawa, Hidefumi et. al.
Anchimeric assistance effect on regioselective hydrolysis of branched PEGs: a mechanistic investigation
score: 0.76389198, Bioorganic & Medicinal Chemistry, 2004, Guiotto, Andrea et. al.
YcaO domains utilize ATP to activate amide backbones during peptide cyclodehydrations
score: 0.76380032, Nature chemical biology, 2012, Dunbar, Kyle L; Melby, Joel O; Mitchell, Douglas A
DNA binding, cytotoxicity, apoptotic inducing activity, and molecular modeling study of quercetin zinc(II) complex
score: 0.76379524, Bioorganic & Medicinal Chemistry, 2009, Tan, Jun; Wang, Bochu; Zhu, Liancai
Chemogenomic approaches to rational drug design.
score: 0.76376888, British journal of pharmacology, 2007, Rognan, D
Enantioselective biocatalytic synthesis of ( S)-monastrol
score: 0.76373993, Bioorganic & Medicinal Chemistry Letters, 2010, Blasco, Maria Alfaro et. al.
Synthesis and Biological Activity of Methanesulfonamide Pyrimidine- and N-Methanesulfonyl Pyrrole-Substituted 3,5-Dihydroxy-6-heptenoates, a Novel Series of HMG-CoA Reductase Inhibitors
score: 0.76371627, Bioorganic & Medicinal Chemistry, 1997, Watanabe, Masamichi et. al.
Fluorescent intercalator displacement analyses of DNA binding by the peptide-derived natural products netropsin, actinomycin, and bleomycin
score: 0.7636871, Bioorganic & Medicinal Chemistry, 2006, Lewis, Mark A.; Long, Eric C.
Integrating virtual screening in lead discovery
score: 0.76342249, Current Opinion in Chemical Biology, 2004, Oprea, Tudor I; Matter, Hans
Ultrasound improves the synthesis of 5-hydroxymethyl-2-mercapto-1-benzylimidazole as a base compound of some pharmaceutical products
score: 0.76302691, European Journal of Medicinal Chemistry, 2008, Entezari, Mohammad H.; Asghari, Azam
Selection of a high-affinity DNA pool for a bZip protein with an out-of-phase alignment of the basic region relative to the leucine zipper
score: 0.76299461, Bioorganic & Medicinal Chemistry, 2001, Lee, Young-sam et. al.
A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11
score: 0.76287911, Bioorganic & Medicinal Chemistry, 2006, Clark, Rachel L. et. al.
Computer-aided drug design and ADMET predictions for identification and evaluation of novel potential farnesyltransferase inhibitors in cancer therapy
score: 0.76271386, Journal of Molecular Graphics and Modelling, 2010, da Silva, Carlos Henrique Tomich de Paula et. al.
Heterogeneous C–C coupling and polymerization catalysts prepared by ROMP
score: 0.7623475, Bioorganic & Medicinal Chemistry Letters, 2002, Buchmeiser, Michael R
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
score: 0.76219646, Nature chemical biology, 2007, Blodgett, Joshua A V et. al.
Synthesis and Evaluation of Novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as Antifungal Agents
score: 0.76213605, Bioorganic & Medicinal Chemistry Letters, 2012, Goel, Richa et. al.
5-Demethylovalicin, as a Methionine Aminopeptidase-2 Inhibitor Produced by Chrysosporium
score: 0.76167483, Bioorganic & Medicinal Chemistry, 2002, Son, Kwang-Hee et. al.
Kinetic and Crystallographic Studies of Glucopyranosylidene Spirothiohydantoin Binding to Glycogen Phosphorylase b
score: 0.76166608, Bioorganic & Medicinal Chemistry, 2002, Oikonomakos, Nikos G et. al.
Prediction of human absorption of natural compounds by the non-everted rat intestinal sac model
score: 0.76140938, European Journal of Medicinal Chemistry, 2006, Ruan, L.-P. et. al.
In vivo insulin-mimetic activity of [ N, N′-1,3-propyl-bis(salicyladimine)]oxovanadium(IV)
score: 0.76119155, European Journal of Medicinal Chemistry, 2007, Xie, Mingjin et. al.
Novel mimics of sialyl Lewis X
score: 0.7609317, Bioorganic & Medicinal Chemistry, 2001, Marinier, Anne et. al.
2,7-Di- tert-butyl-Fmoc-P-OSu: A new polymer-Supported reagent for the protection of the amino group
score: 0.76088215, Bioorganic & Medicinal Chemistry Letters, 2002, Chinchilla, Rafael et. al.
Synthesis and hybridization properties of polyamide based nucleic acid analogues incorporating pyrrolidine-derived nucleoamino acids
score: 0.76077456, Bioorganic & Medicinal Chemistry Letters, 2000, Altmann, Karl-Heinz et. al.
Practical syntheses of dyes for difference gel electrophoresis
score: 0.76068039, Bioorganic & Medicinal Chemistry, 2006, Jung, Michael E.; Kim, Wan-Joong
Synthesis and crystal structure of some transition metal complexes with a novel bis-Schiff base ligand and their antitumor activities
score: 0.76054608, European Journal of Medicinal Chemistry, 2006, Zhong, X. et. al.
Open access chemical and clinical probes to support drug discovery.
score: 0.76033994, Nature chemical biology, 2009, Edwards, Aled M et. al.
The conformational study of chitin and chitosan oligomers in solution
score: 0.75980093, Bioorganic & Medicinal Chemistry, 2001, Sugiyama, Hiroshi et. al.
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.
score: 0.75972356, Nature chemical biology, 2010, Hoffstrom, Benjamin G et. al.
Systems metabolic engineering of microorganisms for natural and non-natural chemicals.
score: 0.75945166, Nature chemical biology, 2012, Lee, Jeong Wook et. al.
Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids
score: 0.75909118, Bioorganic & Medicinal Chemistry, 1995, Hsieh, Hsing-Pang; Muller, James G.; Burrows, Cynthia J.
Fragment-based approaches to enzyme inhibition
score: 0.75869243, Current Opinion in Biotechnology, 2007, Ciulli, Alessio; Abell, Chris
Molecular dynamics of buspirone analogues interacting with the 5-HT 1A and 5-HT 2A serotonin receptors
score: 0.75810886, Bioorganic & Medicinal Chemistry, 2001, Bronowska, Agnieszka et. al.
Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase
score: 0.75807734, Bioorganic & Medicinal Chemistry, 1998, Miura, Tsuyoshi et. al.
A synergistic small molecule combination directly eradicates diverse prion strain structures
score: 0.7579751, Nature chemical biology, 2009, Roberts, Blake E. et. al.
In vitro evolution used to define a protein recognition site within a large RNA domain
score: 0.75796133, Bioorganic & Medicinal Chemistry, 1997, Sapag, Amalia; Draper, David E.
Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones
score: 0.75791141, European Journal of Medicinal Chemistry, 2001, Malamas, Michael S et. al.
Novel inhibitors of the sodium–calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives
score: 0.7575377, European Journal of Medicinal Chemistry, 2001, Rogister, Françoise et. al.
Cytotoxic Cytochalasins from the Endozoic Fungus Phoma sp. of the Giant Jellyfish Nemopilema nomurai
score: 0.757399, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Eun La et. al.
Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion
score: 0.75736075, Bioorganic & Medicinal Chemistry, 2005, Mammana, Angela et. al.
Berberine, a strong polyriboadenylic acid binding plant alkaloid: spectroscopic, viscometric, and thermodynamic study
score: 0.75696241, Bioorganic & Medicinal Chemistry, 2005, Yadav, Ram Chandra et. al.
Molecular modeling and dynamics simulations of PNP from Streptococcus agalactiae
score: 0.75695992, Bioorganic & Medicinal Chemistry, 2008, Caceres, Rafael Andrade et. al.
In vitro characterization of radioiodinated (+)-2-[4-(4-iodophenyl) piperidino]cyclohexanol [(+)-pIV] as a sigma-1 receptor ligand
score: 0.75655354, Bioorganic & Medicinal Chemistry, 2005, Shiba, Kazuhiro; Ogawa, Kazuma; Mori, Hirofumi
Nucleosides and nucleotides—CXXXVII. Antitumor phospholipids with 5-fluorouridine as a cytotoxic polar-head: Synthesis of 5′-phosphatidyl-5-fluorouridines by phospholipase d-catalyzed transphosphatidylation
score: 0.75634384, Bioorganic & Medicinal Chemistry, 1995, Shuto, Satoshi et. al.
Modification of cell response to insulin by membrane-Acting agents in rat white adipocytes: analysis of structural features by computational simulation
score: 0.755873, Bioorganic & Medicinal Chemistry, 2001, Ohkura, Kazuto; Hori, Hitoshi
Chemiluminescence Flow Sensor for Berberine with Immobilized Reagents
score: 0.75567869, Bioorganic & Medicinal Chemistry, 2001, Song, Zhenghua; Zhao, Tiezhu; Wang, Lin; Xiao, Zhen
A Neutral Diphosphate Mimic Crosslinks the Active Site of Human O-GlcNAc Transferase
score: 0.75553242, Nature Chemical Biology, 2011, Jiang, Jiaoyang et. al.
Probing cellular systems with chemistry.
score: 0.75501173, Nature chemical biology, 2007, Hannoush, Rami N
Imidazo[1,5- a]pyrimidine and benzo[4,5]imidazo[1,2- a]pyrimidine derivatives as calcium antagonists
score: 0.75484206, Bioorganic & Medicinal Chemistry, 1994, Alajarin, Ramón et. al.
A model ternary heparin conjugate by direct covalent bond strategy applied to drug delivery system
score: 0.75480263, Bioorganic & Medicinal Chemistry Letters, 2009, Wang, Ying et. al.
A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase—design, synthesis and stability
score: 0.75461582, European Journal of Medicinal Chemistry, 2006, Mucha, A. et. al.
Chemoenzymatic synthesis of N-linked neoglycoproteins through a chitinase-catalyzed transglycosylation
score: 0.75416358, Bioorganic & Medicinal Chemistry, 2008, Li, Cishan; Huang, Wei; Wang, Lai-Xi
Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance
score: 0.75397081, Bioorganic & Medicinal Chemistry, 2004, Gibson, Scott L. et. al.
PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein
score: 0.75343243, Bioorganic & Medicinal Chemistry, 1996, Nilsson, Ulf et. al.
Study on the multiple mechanisms underlying the reaction between hydroxyl radical and phenolic compounds by qualitative structure and activity relationship
score: 0.75337515, Bioorganic & Medicinal Chemistry, 2002, Cheng, Zhiyong et. al.
Synthesis of [ 11C]FEDAA1106 as a new PET imaging probe of peripheral benzodiazepine receptor expression
score: 0.75337031, European Journal of Medicinal Chemistry, 2009, Wang, Min et. al.
Powerful antioxidative agents based on garcinoic acid from Garcinia kola
score: 0.75323293, Bioorganic & Medicinal Chemistry, 2002, Terashima, Kenji; Takaya, Yoshiaki; Niwa, Masatake
Enzymatic synthesis of (2 E,4 E)-(6 R,10 R)-4,6,10,12-tetramethyl-2,4-tridecadien-7-one, the sex pheromone of Matsucoccus matsumurae Japanese pine bast scale
score: 0.75314261, Bioorganic & Medicinal Chemistry, 1996, Lin, Guo-Qiang; Xu, Wei-Chu
Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.
score: 0.75302211, Nature chemical biology, 2006, Gama, Cristal I et. al.
Mining and engineering natural-product biosynthetic pathways.
score: 0.75279424, Nature chemical biology, 2007, Wilkinson, Barrie; Micklefield, Jason
Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei
score: 0.75270859, Bioorganic & Medicinal Chemistry, 2003, Pasti, Claudia et. al.
Bis- N-nitroso-caged nitric oxides: photochemistry and biological performance test by rat aorta vasorelaxation
score: 0.75245625, Bioorganic & Medicinal Chemistry, 1999, Namiki, Shigeyuki et. al.
RNAi therapeutics: a potential new class of pharmaceutical drugs.
score: 0.75224252, Nature chemical biology, 2006, Bumcrot, David et. al.
Synthesis, characterization and biological studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with bidentate Schiff bases derived by heterocyclic ketone
score: 0.75193471, European Journal of Medicinal Chemistry, 2006, Singh, Kiran; Barwa, Manjeet Singh; Tyagi, Parikshit
Evaluation of the cytotoxic activity of polyethers isolated from Laurencia
score: 0.75189886, Bioorganic & Medicinal Chemistry, 1998, Fernández, JoséJ.; Souto, María L.; Norte, Manuel
Membrane interaction of amphotericin B as single-length assembly examined by solid state NMR for uniformly 13C-enriched agent
score: 0.75162462, Bioorganic & Medicinal Chemistry, 2006, Matsuoka, Shigeru et. al.
Potent and Selective Photo-inactivation of Proteins With Peptoid-Ruthenium Conjugates
score: 0.75161131, Nature chemical biology, 2010, Lee, Jiyong et. al.
Correlation of calculated molecular orbital energies of some phenothiazine compounds with MDR reversal properties
score: 0.7514316, European Journal of Medicinal Chemistry, 2006, Hilgeroth, Andreas et. al.
Pharmacokinetics of ertapenem in healthy young volunteers.
score: 0.75134578, Antimicrobial agents and chemotherapy, 2002, Majumdar, A K et. al.
Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site
score: 0.75133973, Bioorganic & Medicinal Chemistry, 1994, Schove, Laura T.; Perez, Juan J.; Loew, Gilda H.
Antimicrobial and Anti-Lipase Activity of Quercetin and its C2-C16 3-O-Acyl-Esters
score: 0.75114189, Bioorganic & Medicinal Chemistry, 2002, Gatto, Maria Teresa et. al.
Psammaplin A, a chitinase inhibitor isolated from the fijian marine sponge Aplysinella rhax
score: 0.75110157, Bioorganic & Medicinal Chemistry, 2002, Tabudravu, J.N et. al.
Saccharides as efficacious solubilisers for highly lipophilic compounds in aqueous media
score: 0.7510204, Bioorganic & Medicinal Chemistry, 2004, Bertau, Martin; Jörg, Gerhard
A theoretical study on the structure–activity relationships of metabolites of folates as antioxidants and its implications for rational design of antioxidants
score: 0.75065987, Bioorganic & Medicinal Chemistry, 2005, Ji, Hong-Fang; Tang, Guang-Yan; Zhang, Hong-Yu
Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis
score: 0.75036619, Nature chemical biology, 2010, Castoreno, Adam B. et. al.
Antitumor agents 220. Antitumor-Promoting effects of cimigenol and related compounds on Epstein–Barr virus activation and two-stage mouse skin carcinogenesis
score: 0.75018485, Bioorganic & Medicinal Chemistry, 2003, Sakurai, Nobuko et. al.
Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA
score: 0.74951746, European Journal of Medicinal Chemistry, 2009, Rehman, Zia-ur et. al.
Intercalation of water-soluble bis-Porphyrins into Poly(dA)-Poly(dT) double helix
score: 0.7489718, Bioorganic & Medicinal Chemistry, 2001, Okada, Hisatsugu; Imai, Hiroyasu; Uemori, Yoshio
Bioorganic chemistry of cyclic ADP-ribose (cADPR) 1 In memory of Sir Derek H. R. Barton, 1918–1998. 1
score: 0.74892742, Bioorganic & Medicinal Chemistry, 1999, Zhang, Fang-Jie; Gu, Qu-Ming; Sih, Charles J
Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells
score: 0.74887451, Bioorganic & Medicinal Chemistry, 2006, Fan, Chuandong et. al.
New carbamoylpiperidines as human platelet aggregation inhibitors
score: 0.7487512, Bioorganic & Medicinal Chemistry, 2000, Guo, Zhengming et. al.
Biotransformation of a 4(20),11(12)-taxadiene derivative
score: 0.74853414, Bioorganic & Medicinal Chemistry, 2001, Sun, Di-An et. al.
Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: Key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action
score: 0.74842159, Bioorganic & Medicinal Chemistry, 2012, Vázquez, Ramiro et. al.
Cellular uptake of N-methylpyrrole/ N-methylimidazole polyamide-dye conjugates
score: 0.74824121, Bioorganic & Medicinal Chemistry, 2002, Belitsky, Jason M et. al.
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3.
score: 0.74792624, Nature chemical biology, 2007, Galonić, Danica P et. al.
Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17β-hydroxysteroid dehydrogenase (17-β-HSD type 1)
score: 0.74792162, Bioorganic & Medicinal Chemistry, 1995, Tremblay, Martin R.; Auger, Serge; Poirier, Donald
On the mechanism of human intestinal absorption
score: 0.74775475, European Journal of Medicinal Chemistry, 2002, Abraham, Michael H. et. al.
Strength in diversity: a cross-disciplinary approach to graduate training in chemical biology.
score: 0.74764171, Nature chemical biology, 2006, Silvius, John
Helical templating of oligopeptides by cyclodextrin dimers
score: 0.74753438, Bioorganic & Medicinal Chemistry, 2003, Wilson, David; Perlson, Lisa; Breslow, Ronald
α-Glucosidase inhibition of natural curcuminoids and curcumin analogs
score: 0.7473915, European Journal of Medicinal Chemistry, 2006, Du, Zhi-yun et. al.
Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives
score: 0.74732821, European Journal of Medicinal Chemistry, 2005, Habala, Ladislav et. al.
Assessing the preferred solution conformation of an interacting sense–antisense (complementary) peptide pair
score: 0.74730234, Bioorganic & Medicinal Chemistry Letters, 2013, Pullen, James R. et. al.
Position-specific incorporation of a highly photodurable and blue-laser excitable fluorescent amino acid into proteins for fluorescence sensing
score: 0.74723607, Bioorganic & Medicinal Chemistry, 2005, Hamada, Hiroyuki et. al.
Polyamidoamine dendrimers used as solubility enhancers of ketoprofen
score: 0.74660869, European Journal of Medicinal Chemistry, 2005, Yiyun, Cheng; Tongwen, Xu; Rongqiang, Fu
In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species.
score: 0.74612674, Antimicrobial agents and chemotherapy, 2004, Maes, Louis et. al.
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening
score: 0.74608044, Bioorganic & Medicinal Chemistry, 2005, Novaroli, Laura et. al.
Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels
score: 0.7458694, Bioorganic & Medicinal Chemistry, 2012, Kato, Eiko; Takahashi, Noriko
Follow the leader: the use of leader peptides to guide natural product biosynthesis.
score: 0.74584638, Nature chemical biology, 2010, Oman, Trent J; van der Donk, Wilfred A
O-Methylasparvenone, a nitrogen-free serotonin antagonist
score: 0.74570781, Bioorganic & Medicinal Chemistry, 1997, Bös, Michael et. al.
Inhibitors of Bcr-abl... breaking new ground again.
score: 0.74534257, Nature chemical biology, 2006, Ohren, Jeffrey F; Sebolt-Leopold, Judith S
Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold
score: 0.74510766, Bioorganic & Medicinal Chemistry, 2003, Wei, Liuqing et. al.
Fluorescein-labeled sinistrin as marker of glomerular filtration rate
score: 0.74508905, European Journal of Medicinal Chemistry, 2005, Pill, Johannes et. al.
Small molecules: the missing link in the central dogma.
score: 0.74480528, Nature chemical biology, 2005, Schreiber, Stuart L
NO donors, part 8 [1]: synthesis and vasodilating activities of substituted benzylnitrates compared to cyclohexylmethylnitrate and GTN
score: 0.74475614, European Journal of Medicinal Chemistry, 2003, Weßler, Christoph et. al.
A new infrared fluorescent-Labeling agent and labeled antibody for diagnosing microcancers
score: 0.74457673, Bioorganic & Medicinal Chemistry, 2003, Tadatsu, Masaya et. al.
Structure-activity studies of the inhibition of serine β-lactamases by phosphonate monoesters
score: 0.74456502, Bioorganic & Medicinal Chemistry, 1997, Li, Naixin; Rahil, Jubrail; Wright, Margaret E.; Pratt, R.F.
Synthesis and β-Adrenergic Properties of ( Z)- N-[3-(Alkylamino)-2-hydroxypropylidene](aryl-methyloxy)amines: Effects of the Configuration Around the Methyloxyiminomethyl (MOIM) Double Bond on the Biopharmacological Properties of MOIM-type β-Blocking Agents
score: 0.74448162, Bioorganic & Medicinal Chemistry, 1998, Balsamo, Aldo et. al.
The Enantiomers of Carbocyclic 5′-Norguanosine: Activity towards Epstein–Barr Virus
score: 0.74447701, Bioorganic & Medicinal Chemistry, 2002, Rajappan, Vasanthakumar et. al.
An Escherichia coli system expressing human deoxyribonucleoside salvage enzymes for evaluation of potential antiproliferative nucleoside analogs.
score: 0.74429805, Antimicrobial agents and chemotherapy, 1998, Wang, J; Neuhard, J; Eriksson, S
Parallel suspension polymerization for high-throughput resin synthesis
score: 0.74392457, Bioorganic & Medicinal Chemistry Letters, 2002, Reger, Thomas S; Janda, Kim D
Chemical Neurobiology—Introduction
score: 0.74384777, Bioorganic & Medicinal Chemistry, 2010, Trauner, Dirk
Optimisation of correlation weights of SMILES invariants for modelling oral quail toxicity
score: 0.74382794, European Journal of Medicinal Chemistry, 2007, Toropov, Andrey A.; Benfenati, Emilio
An easy preparation of ‘monolithic type’ hydrophilic solid phase: Capability for affinity resin to isolate target proteins
score: 0.74353244, Bioorganic & Medicinal Chemistry, 2006, Mori, Tomoko et. al.
Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity
score: 0.74345392, European Journal of Medicinal Chemistry, 2005, Tyagi, Yogesh K. et. al.
Synthesis, crystal structure and initial biological evaluation of the new enantiomerically pure chiral palladium(II) complex trans-bis{endo-(1 R)-1,7,7-trimethylbicyclo[2.2.1]-heptan-2-amino}palladium(II)dichloride
score: 0.74342953, European Journal of Medicinal Chemistry, 2002, Abu-Surrah, Adnan S et. al.
Preparation and evaluation of the in vitro erythroid differentiation induction properties of some esters of methyl 3,4- O-isopropylidene-β- d-galactopyranoside and 2,3- O-isopropylidene- d-mannofuranose
score: 0.74339, Bioorganic & Medicinal Chemistry, 2002, Catelani, Giorgio et. al.
Synthesis, physicochemical and in vitro pharmacological investigation of new platinum (II) complexes with some cycloalkanespiro-5′-hydantoins
score: 0.74323507, European Journal of Medicinal Chemistry, 2005, Bakalova, Adriana et. al.
A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs
score: 0.74303706, Bioorganic & Medicinal Chemistry, 2001, Tietze, Lutz F. et. al.
New propylamine oligopyrrole carboxamides linked to a heterocyclic or anthraquinone system: synthesis, DNA binding, topoisomerase I inhibition and cytotoxicity
score: 0.74284743, European Journal of Medicinal Chemistry, 2003, Hotzel, Christian; Marotto, Annalisa; Pindur, Ulf
Nox2 redox signaling maintains essential cell populations in the brain.
score: 0.7425814, Nature chemical biology, 2011, Dickinson, Bryan C et. al.
Synthesis, cellular internalization and photodynamic activity of glucoconjugated derivatives of tri and tetra( meta-hydroxyphenyl)chlorins
score: 0.74242597, Bioorganic & Medicinal Chemistry, 2003, Laville, I et. al.
Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels
score: 0.74182572, Bioorganic & Medicinal Chemistry, 2012, Kato, Eiko; Takahashi, Noriko
Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels
score: 0.74182572, Bioorganic & Medicinal Chemistry, 2012, Kato, Eiko; Takahashi, Noriko
Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels
score: 0.74182572, Bioorganic & Medicinal Chemistry, 2012, Kato, Eiko; Takahashi, Noriko
Trading molecules and tracking targets in symbiotic interactions.
score: 0.74172816, Nature chemical biology, 2008, Schmidt, Eric W
Simplified fast and high yielding automated synthesis of [ 18F]fluoroethylcholine for prostate cancer imaging
score: 0.74163352, Bioorganic & Medicinal Chemistry, 2008, Zuhayra, M. et. al.
Novel tetrahydropyran-based peptidomimetics from a bioisosteric transformation of a tripeptide. Evidence of their activity at melanocortin receptors
score: 0.74116471, Bioorganic & Medicinal Chemistry, 2003, Mazur, Adam W et. al.
Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity
score: 0.74110245, European Journal of Medicinal Chemistry, 2004, Turan-Zitouni, Gülhan et. al.
Xanthones as inhibitors of microsomal lipid peroxidation and TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs)
score: 0.74102744, Bioorganic & Medicinal Chemistry, 2002, Madan, Babita et. al.
Synthesis, antitumour activity and structure–activity relationships of 5 H-benzo[ b]carbazoles
score: 0.74095982, Bioorganic & Medicinal Chemistry, 2005, Asche, Christian et. al.
LYP inhibits T cell activation when dissociated from CSK
score: 0.74088634, Nature chemical biology, 2012, Vang, Torkel et. al.
Unprecedented overmetabolism of a porphyrinogen substrate by coproporphyrinogen oxidase
score: 0.74086638, Bioorganic & Medicinal Chemistry Letters, 2002, Lash, Timothy D. et. al.
Glycosylation of sialyl acetates with a novel catalyst combination: Bismuth triflate and BF 3·OEt 2 system
score: 0.74075058, Bioorganic & Medicinal Chemistry, 2003, Ikeda, Kiyoshi et. al.
Synthesis, characterization and antimicrobial activity of water soluble dendritic macromolecules
score: 0.74050151, European Journal of Medicinal Chemistry, 2009, Tulu, Metin et. al.
Imidazole substituted biphenyls: A new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer
score: 0.74045972, Bioorganic & Medicinal Chemistry, 1999, Wachall, Bertil G. et. al.
Expanding chemical biology of 2-oxoglutarate oxygenases.
score: 0.74023243, Nature chemical biology, 2008, Loenarz, Christoph; Schofield, Christopher J
DNA sequence-specific recognition of peptides incorporating the HPRK and polyamide motifs
score: 0.74016918, Bioorganic & Medicinal Chemistry, 2004, Chang, Jung-Cheng et. al.
Structural basis for ligand recognition at the benzodiazepine binding site of GABA A α3 receptor, and pharmacophore-based virtual screening approach
score: 0.73986273, Journal of Molecular Graphics and Modelling, 2008, Vijayan, R.S.K.; Ghoshal, Nanda
Synthesis and receptor binding affinity of new selective GluR5 ligands
score: 0.73974498, Bioorganic & Medicinal Chemistry, 2001, Bunch, Lennart et. al.
3-Hydroxy-(4 H)-benzopyran-4-ones as potential iron chelating agents in vivo
score: 0.73959724, Bioorganic & Medicinal Chemistry, 2001, Ferrali, Marco et. al.
Commentary to “The structure of McN-5652” [Bioorg. Med. Chem. 9 (2001) 2105] ☆ ☆ PII of article: S0968-0896(01)00117-1 and to the corrigendum to “The structure of McN-5652” [Bioorg. Med. Chem. 10 (2002) 3368] † † PII of corrigendum: S0968-0896(02)00112-8
score: 0.73899721, Bioorganic & Medicinal Chemistry, 2002, Maryanoff, Bruce E
Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis
score: 0.73899065, Bioorganic & Medicinal Chemistry, 2003, Ravikumar, Vasulinga T et. al.
Steady-state pharmacokinetics of amprenavir coadministered with ritonavir in human immunodeficiency virus type 1-infected patients.
score: 0.7388063, Antimicrobial agents and chemotherapy, 2003, Goujard, Cecile et. al.
CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2- a]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors
score: 0.73848502, European Journal of Medicinal Chemistry, 2001, Castro, Ana et. al.
Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.
score: 0.73812367, Nature chemical biology, 2008, Wang, Zheming et. al.
Synthesis and biological evaluation of thioglycosylated porphyrins for an application in photodynamic therapy
score: 0.73800659, Bioorganic & Medicinal Chemistry, 2002, Sylvain, I et. al.
Endomorphin 2 analogues containing Dmp residue as an aromatic amino acid surrogate with high μ-opioid receptor affinity and selectivity
score: 0.73792366, Bioorganic & Medicinal Chemistry, 2003, Sasaki, Yusuke et. al.
Photodynamic therapy for Acinetobacter baumannii burn infections in mice.
score: 0.73742907, Antimicrobial agents and chemotherapy, 2009, Dai, Tianhong et. al.
Preparation of celecoxib-dimethyl-β-cyclodextrin inclusion complex: characterization and in vitro permeation study
score: 0.73730595, European Journal of Medicinal Chemistry, 2005, Ventura, Cinzia Anna et. al.
Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids
score: 0.73729483, Bioorganic & Medicinal Chemistry, 2006, Klimentová, Jana et. al.
Improvement of ACE inhibitory activity of chitooligosaccharides (COS) by carboxyl modification
score: 0.73716959, Bioorganic & Medicinal Chemistry, 2005, Huang, Ronghua; Mendis, Eresha; Kim, Se-Kwon
Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 6: hydrolysis of 7,8-diacetoxy-4-methylcoumarin by a novel deacetylase in rat liver microsomes — a simple method for assay and characterisation
score: 0.73702872, Bioorganic & Medicinal Chemistry, 2000, Raj, Hanumantha Rao G et. al.
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.
score: 0.73700771, Nature chemical biology, 2011, Ismail, Shehab A et. al.
Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists
score: 0.73697603, Bioorganic & Medicinal Chemistry, 2006, Kanuma, Kosuke et. al.
Chlorine atom substitution influences radical scavenging activity of 6-chromanol
score: 0.73692705, Bioorganic & Medicinal Chemistry, 2012, Inami, Keiko et. al.
Palladium(II) and platinum(II) complexes of a symmetric Schiff base derived from 2,6,diformyl-4-methylphenol with N-aminopyrimidine: Synthesis, characterization and detection of DNA interaction by voltammetry
score: 0.73668317, European Journal of Medicinal Chemistry, 2010, Sönmez, Mehmet; Çelebi, Metin; Yardım, Yavuz; Şentürk, Zühre
Homoepiboxidines
score: 0.7363718, Bioorganic & Medicinal Chemistry, 2004, Fitch, Richard W. et. al.
Antifungal therapy of Aspergillus invasive otitis externa: efficacy of voriconazole and review.
score: 0.73632514, Antimicrobial agents and chemotherapy, 2009, Parize, Perrine et. al.
Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense
score: 0.73602623, Bioorganic & Medicinal Chemistry, 2008, Hsieh, Yves S.-Y. et. al.
Structure-activity relationships of first bishydroxymethyl-substituted cage dimeric 4-aryl-1,4-dihydropyridines as HIV-1 protease inhibitors
score: 0.73558405, European Journal of Medicinal Chemistry, 2003, Hilgeroth, Andreas; Lilie, Hauke
Probing crucial metabolic pathways in fungal pathogens of crucifers: biotransformation of indole-3-acetaldoxime, 4-hydroxyphenylacetaldoxime, and their metabolites
score: 0.73481398, Bioorganic & Medicinal Chemistry, 2003, Pedras, M.Soledade C; Montaut, Sabine
Discovery of novel glitazones incorporated with phenylalanine and tyrosine: Synthesis, antidiabetic activity and structure–activity relationships
score: 0.73430448, Bioorganic Chemistry, 2012, Prashantha Kumar, B.R. et. al.
Discovery of novel glitazones incorporated with phenylalanine and tyrosine: Synthesis, antidiabetic activity and structure–activity relationships
score: 0.73430448, Bioorganic Chemistry, 2012, Prashantha Kumar, B.R. et. al.
Discovery of novel glitazones incorporated with phenylalanine and tyrosine: Synthesis, antidiabetic activity and structure–activity relationships
score: 0.73430448, Bioorganic Chemistry, 2012, Prashantha Kumar, B.R. et. al.
A reversible monoamine oxidase a inhibitor, befloxatone: structural approach of its mechanism of action
score: 0.73409886, Bioorganic & Medicinal Chemistry, 1999, Wouters, Johan et. al.
Electron transfer in N-hydroxyurea complexes with iron(III)
score: 0.73398366, European Journal of Medicinal Chemistry, 2005, Nigović, Biljana; Kujundžić, Nikola; Sanković, Krešimir
Structural advantage of dendritic poly( l-lysine) for gene delivery into cells
score: 0.73373955, Bioorganic & Medicinal Chemistry, 2007, Yamagata, Masato et. al.
Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B 1-DNA binding in vitro
score: 0.73356416, Bioorganic & Medicinal Chemistry, 1996, Raj, Hanumantharao G. et. al.
A sweet success for substrate engineering.
score: 0.7335081, Nature chemical biology, 2006, Griffith, Byron R; Thorson, Jon S
Synthesis, characterization, activities, cell uptake and DNA binding of trinuclear complex: [{ trans-PtCl(NH 3)} 2 μ-{ trans-Pt(NH 3)(2-hydroxypyridine)-(H 2N(CH 2) 6NH 2) 2]Cl 4
score: 0.73347884, European Journal of Medicinal Chemistry, 2005, Cheng, Howard; Huq, Fazlul; Beale, Philip; Fisher, Keith
Modulation of nucleic acid structure by ligand binding: induction of a DNA·RNA·DNA hybrid triplex by DAPI intercalation
score: 0.73337982, Bioorganic & Medicinal Chemistry, 1997, Xu, Zhitao et. al.
Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the In vivo serotonin transporter imaging with PET
score: 0.73301606, Bioorganic & Medicinal Chemistry, 2002, Karramkam, Mylène et. al.
The reaction of artemisinins with hemoglobin: A unified picture
score: 0.73253748, Bioorganic & Medicinal Chemistry, 2006, Messori, Luigi et. al.
Platelet aggregation and antibacterial effects of an l-amino acid oxidase purified from Bothrops alternatus snake venom
score: 0.73252754, Bioorganic & Medicinal Chemistry, 2004, Stábeli, Rodrigo G. et. al.
Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives
score: 0.73250892, European Journal of Medicinal Chemistry, 2012, Secci, Daniela et. al.
Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives
score: 0.73250892, European Journal of Medicinal Chemistry, 2012, Secci, Daniela et. al.
DNA targeting of two new antitumour rebeccamycin derivatives
score: 0.73247573, European Journal of Medicinal Chemistry, 2002, Facompré, Michaël et. al.
New polycyclic pyrimidine derivatives with antiplatelet in vitro activity: synthesis and pharmacological screening
score: 0.73212995, Bioorganic & Medicinal Chemistry, 2001, Bruno, Olga et. al.
Interacting RNA species identified by combinatorial selection
score: 0.73198197, Bioorganic & Medicinal Chemistry, 1997, Cho, Bongrae et. al.
Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes
score: 0.73177538, Bioorganic & Medicinal Chemistry, 2003, Passarella, Daniele et. al.
Application of enzymatically stable dipeptides for enhancement of intestinal permeability. Synthesis and In vitro evaluation of dipeptide-Coupled compounds
score: 0.73165905, Bioorganic & Medicinal Chemistry, 2001, Friedrichsen, Gerda M. et. al.
Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one
score: 0.73135298, European Journal of Medicinal Chemistry, 2013, Patil, Vijay S. et. al.
Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one
score: 0.73135298, European Journal of Medicinal Chemistry, 2013, Patil, Vijay S. et. al.
Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidinesAre Highly Active CDK9 Inhibitors: Synthesis, X-ray CrystalStructures, Structure–Activity Relationship, and AnticancerActivities
score: 0.73107422, Journal of Medicinal Chemistry, 2013, Shao, Hao et. al.
Synthesis and biological evaluation of some novel 4 H-benzopyran-4-one derivatives as nonsteroidal antiestrogens
score: 0.73104678, European Journal of Medicinal Chemistry, 2001, Ismail, Khadiga Ahmed; Abd El Aziem, Tarek
Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation.
score: 0.73080307, Nature chemical biology, 2010, Chatterjee, Champak et. al.
Syntheses of amino nitrones. Potential intramolecular traps for radical intermediates in monoamine oxidase-catalyzed reactions
score: 0.7306239, Bioorganic & Medicinal Chemistry, 1998, Zhong, Boyu; Lu, Xingliang; Silverman, Richard B.
Structure–Activity Studies of Glucose Transfer: Determination of the Spontaneous Rates of Hydrolysis of Uridine 5′-Diphospho-α- d-glucose (UDPG) and Uridine 5′-diphospho-α- d-glucuronic acid (UDPGA)
score: 0.73035367, Bioorganic & Medicinal Chemistry, 2003, Bedford, Colin T; Hickman, Alan D; Logan, Christopher J
Spectroscopic Studies of PhTX Facilitated Cation Movement Across Membranes
score: 0.73016752, Bioorganic & Medicinal Chemistry, 1999, Huang, Xuefei et. al.
Dodecaborate lipid liposomes as new vehicles for boron delivery system of neutron capture therapy
score: 0.73008151, Bioorganic & Medicinal Chemistry, 2010, Ueno, Manabu et. al.
Effect of fluoxetine on pharmacokinetics of ritonavir.
score: 0.72998803, Antimicrobial agents and chemotherapy, 1998, Ouellet, D et. al.
Higher reactivity of apolipoprotein B-100 and α-tocopherol compared to sialic acid moiety of low-density lipoprotein (LDL) in radical reaction
score: 0.72974508, Bioorganic & Medicinal Chemistry, 2003, Matsukawa, Nao et. al.
Molecular design of protein-based nanocapsules for stimulus-responsive characteristics
score: 0.72957614, Bioorganic & Medicinal Chemistry, 2009, Sao, Kentaro et. al.
Mechanism of biochemical action of substituted benzopyran-2-ones. part 8: acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom
score: 0.72911159, Bioorganic & Medicinal Chemistry, 2001, Raj, Hanumantharao G et. al.
Bis-pyrene-labeled molecular beacon: A monomer–excimer switching probe for the detection of DNA base alteration
score: 0.72909651, Bioorganic & Medicinal Chemistry, 2008, Yamana, Kazushige et. al.
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase
score: 0.72906418, Chemistry & Biology, 2001, Tondi, Donatella et. al.
7α- and 17α-Substituted estrogens containing tridentate tricarbonyl rhenium/Technetium complexes: synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m
score: 0.72903448, Bioorganic & Medicinal Chemistry, 2003, Luyt, Leonard G. et. al.
Separation of α-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline
score: 0.72891204, Bioorganic & Medicinal Chemistry, 1995, Brasili, Livio et. al.
Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides
score: 0.72890912, Bioorganic & Medicinal Chemistry, 2006, Ainge, Gary D. et. al.
Preparation of Glycosylated Amino Acid Derivatives for Glycoprotein Synthesis by In Vitro Translation System
score: 0.72888108, Bioorganic & Medicinal Chemistry, 2002, Manabe, Shino et. al.
Chemistry in living systems.
score: 0.72879904, Nature chemical biology, 2005, Prescher, Jennifer A; Bertozzi, Carolyn R
Aurine tricarboxylic acid, a potent metal-chelating inhibitor of NFκB–DNA binding
score: 0.72870389, Bioorganic & Medicinal Chemistry, 2000, Kumar Sharma, Rakesh et. al.
Parthenolide and its photochemically synthesized 1(10) Z isomer: chemical reactivity and structure–activity relationship studies in human leucocyte chemotaxis
score: 0.72835124, Bioorganic & Medicinal Chemistry, 2003, Neukirch, Hannes et. al.
A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin
score: 0.7283317, Nature Chemical Biology, 2012, Villalobos, Luz Irina A. Calderón et. al.
Bioactivation of carbamate-based 20( S)-camptothecin prodrugs
score: 0.72810911, Bioorganic & Medicinal Chemistry, 2004, Pessah, Neta et. al.
Cell binding, uptake and cytosolic partition of HIV anti- gag Phosphodiester oligonucleotides 3′-linked to cholesterol derivatives in macrophages
score: 0.72794428, Bioorganic & Medicinal Chemistry, 1999, LeDoan, Trung et. al.
Computational screening of combinatorial libraries
score: 0.72759316, Bioorganic & Medicinal Chemistry, 1996, Zheng, Qiang; Kyle, Donald J.
1 Finding Protein Kinase Hits using Structural Information
score: 0.72745879, Progress in Medicinal Chemistry, 2006, Cherry, Mike; Reader, John; Williams, David
Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand
score: 0.72737101, Bioorganic & Medicinal Chemistry, 2005, James, Michelle L. et. al.
Inhibition of papain with 2-benzyl-3,4-epoxybutanoic acid esters. Mechanistic and stereochemical probe for cysteine protease catalysis
score: 0.72690219, Bioorganic & Medicinal Chemistry, 1997, Kim, Dong H.; Jin, Yonghao; Ryu, Choon Ho
The Chemistry of Catechol- O-Methyltransferase Inhibitors
score: 0.72677945, International Review of Neurobiology, 2010, Learmonth, David A. et. al.
Reversible signal regulation system of 19F NMR by redox reactions using a metal complex as a switching module
score: 0.72662282, Bioorganic & Medicinal Chemistry, 2009, Tanaka, Kazuo et. al.
Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin
score: 0.72652946, Bioorganic & Medicinal Chemistry, 1995, Boger, Dale L. et. al.
Mapping of Possible Binding Sequences of Two Beta-Sheet Breaker Peptides on Beta Amyloid Peptide of Alzheimer's Disease
score: 0.72637893, Bioorganic & Medicinal Chemistry, 2002, Hetényi, Csaba; Körtvélyesi, Tamás; Penke, Botond
Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents
score: 0.72632861, Bioorganic & Medicinal Chemistry, 2003, Feng, Jianghua; Sun, Guoying; Pei, Fengkui; Liu, Maili
Stereocontrolled synthesis of C-glycosides: Further studies on the organolithium reagents derived from 2-deoxy- d-glucose and d-glucose
score: 0.726296, Bioorganic & Medicinal Chemistry, 1994, Lesimple, Patrick; Beau, Jean-Marie
Postgenomic chemical biology.
score: 0.72616222, Nature chemical biology, 2010,
Natural ozone scavenger prevents asthma in sensitized rats
score: 0.7260782, Bioorganic & Medicinal Chemistry, 2005, Keinan, Ehud et. al.
Chemical identification, electrophysiological and behavioral activities of the pheromone of Metamasius hemipterus (Coleoptera: Curculionidae)
score: 0.72606731, Bioorganic & Medicinal Chemistry, 1996, Ramirez-Lucas, Pamela et. al.
Prediction of aqueous solubility for a diverse set of organic compounds based on atom-type electrotopological state indices
score: 0.72577078, European Journal of Medicinal Chemistry, 2000, Huuskonen, Jarmo; Rantanen, Jukka; Livingstone, David
Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain
score: 0.72537613, Bioorganic & Medicinal Chemistry, 2001, Camarero, Julio A et. al.
HIV-1 protease inhibitors containing an N-Hydroxyamino acid core structure
score: 0.72514335, Bioorganic & Medicinal Chemistry, 2001, Marastoni, Mauro et. al.
Preferential target is mitochondria in α-mangostin-induced apoptosis in human leukemia HL60 cells
score: 0.72455123, Bioorganic & Medicinal Chemistry, 2004, Matsumoto, Kenji et. al.
Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates
score: 0.72441738, Bioorganic & Medicinal Chemistry, 1998, Boxus, Thierry et. al.
Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure
score: 0.72416824, European Journal of Medicinal Chemistry, 2012, Siddiqi, Zafar A. et. al.
Inactivation of bovine plasma amine oxidase by haloallylamines
score: 0.72348248, Bioorganic & Medicinal Chemistry, 2006, Kim, Jisook et. al.
Natural Products in Medicinal Chemistry
score: 0.72322388, Bioorganic & Medicinal Chemistry, 2009, Newman, David; Cragg, Gordon
Homology modelling and binding site mapping of the human histamine H1 receptor
score: 0.72297176, European Journal of Medicinal Chemistry, 2004, Kiss, Róbert; Kovári, Zoltán; Keserű, György M.
Computational discovery of novel low micromolar human pregnane X receptor antagonists.
score: 0.72282527, Molecular pharmacology, 2008, Ekins, Sean et. al.
The role of dynamic conformational ensembles in biomolecular recognition.
score: 0.72280547, Nature chemical biology, 2009, Boehr, David D; Nussinov, Ruth; Wright, Peter E
Synthesis and antioxidant properties of a new lipophilic ascorbic acid analogue
score: 0.72271768, Bioorganic & Medicinal Chemistry, 2003, Cotelle, Philippe et. al.
An in vitro characterization study of new near infrared dyes for molecular imaging
score: 0.72244011, European Journal of Medicinal Chemistry, 2009, Pauli, Jutta et. al.
Synthesis and diuretic activity of bicyclic fused heterocycles containing oxime- O -sulfonic acid moiety
score: 0.72234517, European Journal of Medicinal Chemistry, 2000, Nishijima, Kazumi et. al.
The linkage of catalysis and regulation in enzyme action: oxidative diversion in the hysteretically regulated yeast pyruvate decarboxylase
score: 0.72213961, Bioorganic & Medicinal Chemistry, 1999, Hajipour, Gholamhossein et. al.
Antiviral properties of cobalt(III)-complexes
score: 0.72211033, Bioorganic & Medicinal Chemistry, 2008, Delehanty, James B. et. al.
Synthesis and absolute configuration of hormone alpha1.
score: 0.7220793, Nature chemical biology, 2008, Yajima, Arata et. al.
Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties
score: 0.72207859, European Journal of Medicinal Chemistry, 2006, Sassatelli, Mathieu et. al.
Synthesis and transacylating reactivity of β-cyclodextrin ethylenediamines
score: 0.72146231, Bioorganic & Medicinal Chemistry, 1994, Beeson, John C.; Czarnik, Anthony W.
Labial gland chemistry of three species of bumblebees (Hymenoptera: Apidae) from North America
score: 0.72144577, Bioorganic & Medicinal Chemistry, 1996, Bergström, Gunnar et. al.
Structure–activity relationship of alkanols as mosquito larvicides with novel findings regarding their mode of action
score: 0.72124956, Bioorganic & Medicinal Chemistry, 1999, Hammond, David G; Kubo, Isao
1-Methyl-3-pyrrolines and 2-methylisoindolines: new classes of cyclic tertiary amine monoamine oxidase B substrates
score: 0.72087235, Bioorganic & Medicinal Chemistry, 1998, Wang, You-Xiong; Mabic, Stéphane; Castagnoli Jr, Neal
Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides
score: 0.7206591, Bioorganic & Medicinal Chemistry, 2004, Chen, Hung-Sen et. al.
Synthesis and in vitro antitumour activity evaluation of 1-aryl-1 H,3 H-thiazolo[4,3- b]quinazolines
score: 0.72050095, European Journal of Medicinal Chemistry, 2000, Grasso, Silvana et. al.
Two novel oleanolic acid saponins having a sialyl Lewis X mimetic structure from Achyranthes fauriei root
score: 0.72012325, Bioorganic & Medicinal Chemistry Letters, 1998, Ida, Yoshiteru et. al.
Conformational Studies on the Specific Cleavage Site of Type I Collagen (α-1) Fragment (157–192) by Cathepsins K and L by Proton NMR Spectroscopy
score: 0.71995004, Bioorganic & Medicinal Chemistry, 1999, Nosaka, Atsuko Y et. al.
A new solid-phase synthesis of oligonucleotides 3′-conjugated with peptides
score: 0.71893396, Bioorganic & Medicinal Chemistry, 1999, De Napoli, L et. al.
Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor
score: 0.71868334, Bioorganic & Medicinal Chemistry, 2001, Cane, David E; Chow, Cathy; Lillo, Antonietta; Kang, Ilgu
Synthesis and appetite suppressant activity of 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes as conformationally rigid analogues of fluoxetine
score: 0.71837329, Bioorganic & Medicinal Chemistry, 2006, Bhandari, Kalpana et. al.
n-->pi* interactions in proteins.
score: 0.71812182, Nature chemical biology, 2010, Bartlett, Gail J et. al.
C-Terminal truncation of α 1,6-fucosyltransferase from Rhizobium sp. does not annul the transferase activity of the enzyme
score: 0.71804493, Bioorganic & Medicinal Chemistry, 2002, Bastida, Agatha et. al.
In vitro antitumor activities of 2,6-di-[2-(Heteroaryl)vinyl]pyridines and pyridiniums
score: 0.71799908, Bioorganic & Medicinal Chemistry, 2002, Barresi, Vincenza et. al.
Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex
score: 0.71795561, Bioorganic & Medicinal Chemistry, 2006, Saraf-Levy, Talia et. al.
Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines
score: 0.71774673, Bioorganic & Medicinal Chemistry, 2006, Suhara, Yoshitomo et. al.
Synthesis, characterization and antitumor studies of transition metal complexes of o-hydroxydithiobenzoate
score: 0.71762607, Bioorganic & Medicinal Chemistry, 2002, Shrivastav, Anuraag; Singh, Nand K.; Srivastava, Geeta
Identification of a small-molecule entry inhibitor for filoviruses.
score: 0.71742354, Journal of virology, 2011, Basu, Arnab et. al.
Homology modeling and molecular dynamics studies of a novel C3-like ADP-ribosyltransferase
score: 0.71732917, Bioorganic & Medicinal Chemistry, 2004, Xiao, Jing-fa; Li, Ze-sheng; Sun, Chia-chung
Hydrophilic photolabelling of glycopeptides from the murine liver–intestine (LI) cadherin recognition domain
score: 0.71695474, Bioorganic & Medicinal Chemistry, 2006, Heiner, Sebastian; Detert, Heiner; Kuhn, Axel; Kunz, Horst
Synthesis of novel isoxazolidine derivatives and studies for their antifungal properties
score: 0.71679842, European Journal of Medicinal Chemistry, 2003, Ravi Kumar, Kodagahally R et. al.
Antihypertensive and vasorelaxing activities of synthetic xanthone derivatives
score: 0.71671382, Bioorganic & Medicinal Chemistry, 2002, Wang, Li-Wen et. al.
Synthesis of di- and tripeptide analogues containing α-ketoamide as a new core structure for inhibition of HIV-1 protease
score: 0.71671289, European Journal of Medicinal Chemistry, 2000, Sheha, Mahmoud M et. al.
Characterization of chlorophyll pigments in the mutant lacking 8-vinyl reductase of green photosynthetic bacterium Chlorobaculum tepidum
score: 0.71652227, Bioorganic & Medicinal Chemistry, 2012, Mizoguchi, Tadashi; Harada, Jiro; Tamiaki, Hitoshi
Characterization of chlorophyll pigments in the mutant lacking 8-vinyl reductase of green photosynthetic bacterium Chlorobaculum tepidum
score: 0.71652227, Bioorganic & Medicinal Chemistry, 2012, Mizoguchi, Tadashi; Harada, Jiro; Tamiaki, Hitoshi
Characterization of chlorophyll pigments in the mutant lacking 8-vinyl reductase of green photosynthetic bacterium Chlorobaculum tepidum
score: 0.71652227, Bioorganic & Medicinal Chemistry, 2012, Mizoguchi, Tadashi; Harada, Jiro; Tamiaki, Hitoshi
Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)
score: 0.71602133, Bioorganic & Medicinal Chemistry Letters, 2012, Qian, Wen-Jian et. al.
Discovery and Preliminary SAR of Bisbenzylisoquinoline Alkaloids as Inducers of C/EBPα
score: 0.71599631, Bioorganic & Medicinal Chemistry, 2012, Klausmeyer, Paul et. al.
Synthesis and evaluation of antitumor activities of novel chiral 1,2,4-triazole Schiff bases bearing γ-butenolide moiety
score: 0.71591349, Organic and Medicinal Chemistry Letters, 2012, Li, Xiang et. al.
LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes
score: 0.71568752, Bioorganic & Medicinal Chemistry, 2007, Christiansen, Janne K. et. al.
Use of an aminooxy linker for the functionalization of oligodeoxyribonucleotides
score: 0.71565731, Bioorganic & Medicinal Chemistry Letters, 2001, Defrancq, Eric; Lhomme, Jean
Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides
score: 0.71540344, Bioorganic & Medicinal Chemistry, 2012, Rahman, S.M. Abdur et. al.
Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides
score: 0.71540344, Bioorganic & Medicinal Chemistry, 2012, Rahman, S.M. Abdur et. al.
Acid–base versus structural properties of an aminoglycoside antibiotic––sisomicin: NMR and potentiometric approach
score: 0.71537727, Bioorganic & Medicinal Chemistry, 2004, Krężel, Artur et. al.
Unsymmetrical methylene derivatives of indoles as antiproliferative agents
score: 0.71518537, European Journal of Medicinal Chemistry, 2001, Mazzei, Mauro et. al.
Synthesis and biological evaluation of new clofibrate analogues as potential PPARα agonists
score: 0.71474784, European Journal of Medicinal Chemistry, 2005, Perrone, Maria Grazia et. al.
Grand challenge commentary: Beyond discovery: probes that see, grab and poke.
score: 0.7147238, Nature chemical biology, 2010, Kritzer, Joshua A
Regioselectivity and enantioselectivity in an antibody catalyzed hetero Diels—Alder reaction
score: 0.71449635, Bioorganic & Medicinal Chemistry, 1996, Meekel, Arthur A.P.; Resmini, Marina; Pandit, Upendra K.
An artificial aspartic proteinase system
score: 0.71444112, Bioorganic & Medicinal Chemistry, 2005, Jiang, Lin; Liu, Zhilian; Liang, Zhi; Gao, Yunhua
The association of vitamins C and K 3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy
score: 0.71421955, European Journal of Medicinal Chemistry, 2003, Verrax, Julien et. al.
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors
score: 0.71415222, Bioorganic & Medicinal Chemistry, 2005, Barker, David et. al.
Chemical modulators of autophagy as biological probes and potential therapeutics.
score: 0.71378167, Nature chemical biology, 2011, Fleming, Angeleen et. al.
Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.
score: 0.71280006, Nature chemical biology, 2009, Garner, Kristen M; Pletnev, Alexandre A; Eastman, Alan
Protonated structures of naturally occurring deoxyribonucleic acids and their interaction with berberine
score: 0.71239441, Bioorganic & Medicinal Chemistry, 2005, Bhadra, Kakali et. al.
Small changes in cationic substituents of diphenylfuran derivatives have major effects on the binding affinity and the binding mode with RNA helical duplexes
score: 0.71228345, Bioorganic & Medicinal Chemistry, 1995, Zhao, Min et. al.
Salicylanilides as inhibitors of the protein tyrosine kinase epidermal growth factor receptor
score: 0.71224927, European Journal of Medicinal Chemistry, 2004, Liechti, Christoph et. al.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
score: 0.71218663, Nature chemical biology, 2011, Keller, Tracy L. et. al.
Qualitative prediction of blood–brain barrier permeability on a large and refined dataset
score: 0.7119762, Journal of Computer-Aided Molecular Design, 2011, Muehlbacher, Markus et. al.
QSPR treatment of rat blood:air, saline:air and olive oil:air partition coefficients using theoretical molecular descriptors
score: 0.71193114, Bioorganic & Medicinal Chemistry, 2004, Katritzky, Alan R. et. al.
Synthesis of Abyssinone II and related compounds as potential chemopreventive agents
score: 0.7119153, European Journal of Medicinal Chemistry, 2006, Moriarty, Robert M. et. al.
Impact of mixed-backbone oligonucleotides on target binding affinity and target cleaving specificity and selectivity by Escherichia coli RNase H
score: 0.71180343, Bioorganic & Medicinal Chemistry, 1998, Shen, Ling X; Kandimalla, Ekambar R; Agrawal, Sudhir
Studies on quinones. Part 41: Synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones
score: 0.7115403, Bioorganic & Medicinal Chemistry, 2006, Valderrama, Jaime A. et. al.
Virtual screening against Mycobacterium tuberculosis dihydrofolate reductase: Suggested workflow for compound prioritization using structure interaction fingerprints
score: 0.71111078, Journal of Molecular Graphics and Modelling, 2008, Kumar, Ashutosh; Siddiqi, Mohammad Imran
1 Finding Protein Kinase Hits using Structural Information
score: 0.71106604, Progress in Medicinal Chemistry, 2006, Cherry, Mike; Reader, John; Williams, David
Semisynthetic modifications of hemiaminal function at ornithine unit of mulundocandin, towards chemical stability and antifungal activity
score: 0.71103259, Bioorganic & Medicinal Chemistry, 2003, Lal, Bansi et. al.
Major histocompatibility complex class II binding characteristics of peptoid–peptide hybrids
score: 0.71087093, Bioorganic & Medicinal Chemistry, 2002, de Haan, Ellen C et. al.
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
score: 0.71055304, Nature chemical biology, 2012, Koeberle, Solveigh C et. al.
Saturation-transfer difference NMR studies for the epitope mapping of a carbohydrate-mimetic peptide recognized by an anti-carbohydrate antibody
score: 0.71028946, Bioorganic & Medicinal Chemistry, 2004, Johnson, Margaret A.; Pinto, B.Mario
Corticotropin releasing hormone: therapeutic implications and medicinal chemistry developments
score: 0.71012553, Bioorganic & Medicinal Chemistry, 2000, Keller, Paul A et. al.
Mode of action of escins Ia and IIa and E, Z-senegin II on glucose absorption in gastrointestinal tract
score: 0.710021, Bioorganic & Medicinal Chemistry, 1998, Matsuda, Hisashi et. al.
Use of lipase for regioselective one pot amidation and hydrolysis
score: 0.70999204, Bioorganic & Medicinal Chemistry Letters, 1999, Adamczyk, Maciej; Grote, Jonathan
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids
score: 0.70993739, Bioorganic & Medicinal Chemistry, 2012, Huang, Ling et. al.
6-Substituted 2,2-Bis(fluoromethyl)-benzopyran-4-carboxamide K + channel openers
score: 0.70951418, Bioorganic & Medicinal Chemistry, 2000, Taka, Naoki et. al.
Advantages of cocrystallization in the field of solid-state pharmaceutical chemistry: l-Proline and MnCl 2
score: 0.70945667, European Journal of Medicinal Chemistry, 2010, Tilborg, Anaëlle et. al.
Chemical studies on antioxidant mechanism of tea catechins: analysis of radical reaction products of catechin and epicatechin with 2,2-Diphenyl-1-picrylhydrazyl
score: 0.70937825, Bioorganic & Medicinal Chemistry, 2002, Sang, Shengmin et. al.
Discovery and development of sesquiterpenoid derived hydroxymethylacylfulvene: a new anticancer drug
score: 0.7092762, Bioorganic & Medicinal Chemistry, 1999, McMorris, Trevor C
Polypseudorotaxanes of pegylated α-cyclodextrin/polyamidoamine dendrimer conjugate with cyclodextrins as a sustained release system for DNA
score: 0.70900177, Bioorganic & Medicinal Chemistry, 2012, Motoyama, Keiichi et. al.
Water-soluble chitosan derivatives as a BACE1 inhibitor
score: 0.70871252, Bioorganic & Medicinal Chemistry, 2005, Je, Jae-Young; Kim, Se-Kwon
Imaging amyloid β peptide oligomeric particles in solution
score: 0.70865677, Bioorganic & Medicinal Chemistry, 2005, Dong, Jijun; Apkarian, Robert P.; Lynn, David G.
A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling
score: 0.70852732, Bioorganic & Medicinal Chemistry Letters, 2000, Eisenwiener, Klaus-Peter; Powell, Pia; Mäcke, Helmut R
A peptidyl transferase ribozyme capable of combinatorial peptide synthesis
score: 0.70832012, Bioorganic & Medicinal Chemistry, 2004, Cui, Zhiyong; Sun, Lele; Zhang, Biliang
Publishers' Note
score: 0.7080771, European Journal of Medicinal Chemistry, 2010, Kiruvanayagam, Vijala
Oligosaccharides corresponding to the regular sequence of heparin: chemical synthesis and interaction with FGF-2
score: 0.7078129, Bioorganic & Medicinal Chemistry, 1999, Tabeur, Christine et. al.
Analyses of insulin-potentiating fragments of human growth hormone by computative simulation; essential unit for insulin-Involved biological responses
score: 0.70773624, Bioorganic & Medicinal Chemistry, 2000, Ohkura, Kazuto; Hori, Hitoshi
Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides
score: 0.7076884, Bioorganic & Medicinal Chemistry, 2006, Romeo, Giovanni et. al.
Influence of ligand denticity on the properties of novel cumTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue
score: 0.70762581, Bioorganic & Medicinal Chemistry, 2012, Fernández, Soledad et. al.
Polyketide origin of pheromones of Carpophilus davidsoni and C. mutilatus (Coleoptera: Nitidulidae)
score: 0.70745782, Bioorganic & Medicinal Chemistry, 1996, Bartelt, Robert J.; Weisleder, David
Effects on erythroid differentiation of platinum(II) complexes of synthetic bile acid derivatives
score: 0.70740249, Bioorganic & Medicinal Chemistry, 2006, Lampronti, Ilaria et. al.
DNA Analogues: From Supramolecular Principles to Biological Properties
score: 0.70634354, Bioorganic & Medicinal Chemistry, 2002, Leumann, Christian J.
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease
score: 0.70611406, Bioorganic & Medicinal Chemistry, 2003, Bihel, Frédéric et. al.
Specific inactivation of Escherichia coli tRNA Phe by antisense DNA-treatment under Mg 2+-deficient conditions
score: 0.70602991, Bioorganic & Medicinal Chemistry, 2000, Kanda, Takayuki et. al.
Chiral recognition in the binding of helicenediamine to double strand DNA: interactions between low molecular weight helical compounds and a helical polymer
score: 0.70579774, Bioorganic & Medicinal Chemistry, 2002, Honzawa, Shinobu et. al.
Cyanocobalamin (vitamin B 12) conjugates with enhanced solubility
score: 0.70540868, Bioorganic & Medicinal Chemistry, 2007, Wang, Xiaoyang; Wei, Lianhu; Kotra, Lakshmi P.
The interaction of analogues of the antimicrobial lipopeptide, iturin A 2, with alkali metal ions
score: 0.70506685, Bioorganic & Medicinal Chemistry, 2000, Rautenbach, M; Swart, P; van der Merwe, M.J
Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones
score: 0.70483491, Bioorganic & Medicinal Chemistry, 2001, Kumar, Rajesh et. al.
Synthesis of novel adamantylacetyl derivative of peptidoglycan monomer—biological evaluation of immunomodulatory peptidoglycan monomer and respective derivatives with lipophilic substituents on amino group
score: 0.7047377, Bioorganic & Medicinal Chemistry, 2000, Ljevaković, Đurđica et. al.
Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. strain UC 11065.
score: 0.70468888, Antimicrobial agents and chemotherapy, 2007, Zhang, Xiujun; Parry, Ronald J
A new insulin-enhancing agent: [ N, N′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity
score: 0.70425748, European Journal of Medicinal Chemistry, 2010, Xie, Ming-jin et. al.
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase
score: 0.70412046, European Journal of Medicinal Chemistry, 2012, Breda, Ardala et. al.
Novel anthracycline oligosaccharides: influence of chemical modifications of the carbohydrate moiety on biological activity
score: 0.70355395, Bioorganic & Medicinal Chemistry, 2002, Cipollone, A et. al.
Arthrobacter sp. lipase immobilization for preparation of enantiopure masked β-amino alcohols
score: 0.70343425, Bioorganic & Medicinal Chemistry, 2009, Chaubey, Asha et. al.
Synthesis of 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid: A selective carnitine palmitoyltransferase-1 inhibitor
score: 0.70314658, Bioorganic & Medicinal Chemistry, 1998, Hutchison, Tracy L.; Brouillette, Wayne J.
Multiple glycosylation of de novo designed α-helical coiled coil peptides
score: 0.7030088, Bioorganic & Medicinal Chemistry, 2010, Falenski, Jessica A.; Gerling, Ulla I.M.; Koksch, Beate
A specific substrate-Inhibitor, a 2′-Deoxy-2′-fluorouridine-Containing oligoribonucleotide, against human RNase L
score: 0.70262866, Bioorganic & Medicinal Chemistry, 2003, Ueno, Yoshihito et. al.
Synthesis of a 3-deoxy- l-iduronic acid containing heparin pentasaccharide to probe the conformation of the antithrombin III binding sequence 1 This paper is dedicated to Professor Stuart Schreiber. 1
score: 0.702373, Bioorganic & Medicinal Chemistry, 1998, Lei, Ping-Sheng et. al.
A mass spectrometry-guided genome mining approach for natural product peptidogenomics
score: 0.70229829, Nature Chemical Biology, 2011, Kersten, Roland D. et. al.
Quantitative structure–activity relationship in aziridinyl-1,4-naphthoquinone antimalarials: study of theoretical correlations by the PM3 method
score: 0.70210068, Bioorganic & Medicinal Chemistry, 2004, dos Santos, Elizabeth V.M. et. al.
Effect of polymer grafting density on silica nanoparticle toxicity
score: 0.70186747, Bioorganic & Medicinal Chemistry, 2012, Lin, I-Chun et. al.
Effect of polymer grafting density on silica nanoparticle toxicity
score: 0.70186747, Bioorganic & Medicinal Chemistry, 2012, Lin, I-Chun et. al.
Effect of polymer grafting density on silica nanoparticle toxicity
score: 0.70186747, Bioorganic & Medicinal Chemistry, 2012, Lin, I-Chun et. al.
Hydroxyl radical as a strong electrophilic species
score: 0.70155871, Bioorganic & Medicinal Chemistry, 2002, Marusawa, Hiroshi et. al.
Chemotherapy of leishmaniasis part II: synthesis and bioevaluation of substituted arylketene dithioacetals as antileishmanial agents
score: 0.70153955, European Journal of Medicinal Chemistry, 2005, Pandey, Susmita et. al.
Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate.
score: 0.70126311, Antimicrobial agents and chemotherapy, 2005, Magee, Wendy C; Hostetler, Karl Y; Evans, David H
Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages
score: 0.70106878, Bioorganic & Medicinal Chemistry, 2000, Dirsch, Verena M et. al.
Physicochemical characterization of neuroleptics. Relative stability of 7- and 9-hydroxyrisperidones and their protonated forms in gas phase and in solution
score: 0.70101184, European Journal of Medicinal Chemistry, 2010, Millefiori, S.; Alparone, A.
Targeting cancer cells with biotin–dendrimer conjugates
score: 0.7005598, European Journal of Medicinal Chemistry, 2009, Yang, Wenjun et. al.
Smart drug discovery leveraging innovative technologies and predictive knowledge.
score: 0.70033281, Nature chemical biology, 2006, Sawyer, Tomi K
Hesperetin: an Inhibitor of the Transforming Growth Factor-β (TGF-β) Signaling Pathway
score: 0.69985707, European Journal of Medicinal Chemistry, 2012, Yang, Yong et. al.
Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors
score: 0.69984502, European Journal of Medicinal Chemistry, 2001, Olgen, Sureyya; Akaho, Eiichi; Nebioglu, Dogu
Synthesis, DNA interactions and biological activity of DNA minor groove targeted polybenzamide-linked nitrogen mustards
score: 0.69978583, Bioorganic & Medicinal Chemistry, 1995, Atwell, Graham J. et. al.
Synthesis of 18O-Labelled chlorophyll derivatives at carbonyl oxygen atoms by acidic hydrolysis of the ethylene ketal and acetal
score: 0.69948201, Bioorganic & Medicinal Chemistry, 2003, Morishita, Hidetada; Tamiaki, Hitoshi
Evaluation of [ 18F]VUF 5000 as a potential PET ligand for brain imaging of the histamine H 3 receptor
score: 0.69939223, Bioorganic & Medicinal Chemistry, 1999, Windhorst, Albert D. et. al.
Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study
score: 0.69921845, European Journal of Medicinal Chemistry, 2007, Cheng, Yiyun et. al.
Alcohol-induced denaturation of β-lactoglobulin: a close correlation to the alcohol-induced α-helix formation of melittin
score: 0.69902025, Bioorganic & Medicinal Chemistry, 1999, Hirota-Nakaoka, Nami; Goto, Yuji
A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin.
score: 0.69886329, Nature chemical biology, 2012, Calderón Villalobos, Luz Irina A et. al.
Engineering charge selectivity in model ion channels
score: 0.69882737, Bioorganic & Medicinal Chemistry, 2004, Lougheed, Tyler et. al.
A mass spectrometry-guided genome mining approach for natural product peptidogenomics.
score: 0.69855072, Nature chemical biology, 2011, Kersten, Roland D et. al.
Regioselective synthesis of cyclodextrin mono-substituted conjugates of non-steroidal anti-inflammatory drugs at C-2 secondary hydroxyl by protease in non-aqueous media
score: 0.69829077, Bioorganic & Medicinal Chemistry, 2005, Wang, Na et. al.
Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease
score: 0.69814267, European Journal of Medicinal Chemistry, 2002, Mustazza, Carlo et. al.
Investigation of the chemopreventive potential of neem leaf subfractions in the hamster buccal pouch model and phytochemical characterization
score: 0.69807262, European Journal of Medicinal Chemistry, 2012, Manikandan, Palrasu et. al.
Investigation of the chemopreventive potential of neem leaf subfractions in the hamster buccal pouch model and phytochemical characterization
score: 0.69807262, European Journal of Medicinal Chemistry, 2012, Manikandan, Palrasu et. al.
Mycobactin-mediated iron acquisition within macrophages.
score: 0.69802606, Nature chemical biology, 2005, Luo, Minkui; Fadeev, Evgeny A; Groves, John T
Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives
score: 0.69800802, European Journal of Medicinal Chemistry, 2001, Sridhar, Seshaiah Krishnan et. al.
CC-1065 CBI analogs: an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions
score: 0.69777553, Bioorganic & Medicinal Chemistry, 1995, Boger, Dale L.; Yun, Weiya; Han, Nianhe; Johnson, Douglas S.
Water molecules in hydroxy/acid networks as a competition between dynamics and bonding. Synthesis of a wet hydrophobic pore
score: 0.69776063, Bioorganic & Medicinal Chemistry, 2004, Pérez-Hernández, Natalia et. al.
Locking out viral replication.
score: 0.69714313, Nature chemical biology, 2009, Begley, Darren W; Varani, Gabriele
Synthesis of the enantiomers of lasiol, an acyclic monoterpene alcohol in the mandibular gland secretion of the male ants, lasius meridionalis
score: 0.69696785, Bioorganic & Medicinal Chemistry, 1993, Kasai, Toshibiro; Watanabe, Hidenori; Mon, Kenji
Synthesis and bio-evaluation of a new fatty acid derivative for myocardial imaging
score: 0.69693692, Bioorganic & Medicinal Chemistry, 2008, Mathur, Anupam et. al.
Comparison of the efficiency of various methods for the synthesis of models of metabolites: example of 4a-methylhexahydronaphtalenones
score: 0.69682088, European Journal of Medicinal Chemistry, 2003, Estour, François et. al.
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry.
score: 0.69678041, Nature chemical biology, 2012, Betz, Karin et. al.
X-ray crystallographic structure of ABT-378 (Lopinavir) bound to HIV-1 protease
score: 0.69666981, Bioorganic & Medicinal Chemistry, 2002, Stoll, Vincent et. al.
Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (Niodene) as a potential nicotinic α4β2 receptor imaging agent
score: 0.6962315, Bioorganic & Medicinal Chemistry Letters, 2012, Pandey, Suresh K. et. al.
DNA binding properties of the marine sponge pigment fascaplysin
score: 0.69616242, Bioorganic & Medicinal Chemistry, 2001, Hörmann, Aldo; Chaudhuri, Bhabatosh; Fretz, Heinz
Synthesis and mycological activity of the compounds obtained in the reaction of N 3-substituted amidrazones with sulphinyl-bis-2,4-dihydroxybenzenethioyl
score: 0.69577715, European Journal of Medicinal Chemistry, 2001, Modzelewska-Banachiewicz, Bożena et. al.
Antimicrobial and SOD activities of novel transition metal complexes of pyridine-2,6-dicarboxylic acid containing 4-picoline as auxiliary ligand
score: 0.69575691, European Journal of Medicinal Chemistry, 2010, Siddiqi, Zafar A. et. al.
α- C-Mannosyltryptophan is not recognized by conventional mannose-binding lectins
score: 0.69556076, Bioorganic & Medicinal Chemistry, 2004, Nishikawa, Toshio et. al.
Interaction of cyanine dyes with nucleic acids. Part 19: new method for the covalent labeling of oligonucleotides with pyrylium cyanine dyes
score: 0.69530883, Bioorganic & Medicinal Chemistry Letters, 2000, Yarmoluk, Sergiy M; Kostenko, Alexander M; Dubey, Igor Y
Cooperativity and biological complexity.
score: 0.69421769, Nature chemical biology, 2008, Whitty, Adrian
Synthesis and evaluation of 7-amino-2-(2(3)-furyl)-5-phenylethylamino-oxazolo[5,4- d]pyrimidines as potential A 2A adenosine receptor antagonists for positron emission tomography (PET)
score: 0.6937129, European Journal of Medicinal Chemistry, 2006, Holschbach, Marcus H. et. al.
CoMFA and CoMSIA studies on thiazolidin-4-one as anti-HIV-1 agents
score: 0.69359691, Journal of Molecular Graphics and Modelling, 2009, Murugesan, Vanangamudi et. al.
Benzofuranyl 3,5-bis-Polyamine derivatives as time-Dependent inhibitors of trypanothione reductase
score: 0.69355981, Bioorganic & Medicinal Chemistry, 2003, Hamilton, Chris J. et. al.
Allosteric regulation and catalysis emerge via a common route.
score: 0.69323839, Nature chemical biology, 2008, Goodey, Nina M; Benkovic, Stephen J
Conformationally constrained calcium channel blockers: Novel mimics of 1-benzazepin-2-ones
score: 0.69308235, Bioorganic & Medicinal Chemistry, 1993, Barrish, Joel C. et. al.
Structure of daunomycin complexed to d-TGATCA by two-dimensional nuclear magnetic resonance spectroscopy
score: 0.69277479, European Journal of Medicinal Chemistry, 2006, Barthwal, Ritu et. al.
Computational approaches to structure-based ligand design
score: 0.69272668, Pharmacology and Therapeutics, 1999, Joseph-McCarthy, Diane
Heparin-polynitroxides: synthesis and preliminary evaluation as cardiovascular EPR/MR imaging probes and extracellular space-targeted antioxidants
score: 0.69257143, European Journal of Medicinal Chemistry, 2012, Kleschyov, Andrei L. et. al.
The synthesis and evaluation of benzofuranones as β-Lactamase substrates
score: 0.69252765, Bioorganic & Medicinal Chemistry, 2001, Adediran, S.A et. al.
‘Cyclicons’ as hybridization-based fluorescent primer-probes: synthesis, properties and application in real-time PCR
score: 0.69229787, Bioorganic & Medicinal Chemistry, 2000, Kandimalla, Ekambar R; Agrawal, Sudhir
Chemical biology and the limits of reductionism.
score: 0.69223412, Nature chemical biology, 2008, Peterson, Randall T
Catalytic transformations with copper-metalated diglycine conjugates
score: 0.6920678, Bioorganic & Medicinal Chemistry, 2004, Madhavaiah, C.; Parvez, Masood; Verma, Sandeep
Supplementation of naringenin and its synthetic derivative alters antioxidant enzyme activities of erythrocyte and liver in high cholesterol-fed rats
score: 0.69194732, Bioorganic & Medicinal Chemistry, 2002, Lee, Mi-Kyung et. al.
Mechanistic study of the photodynamic inactivation of Candida albicans by a cationic porphyrin.
score: 0.69188838, Antimicrobial agents and chemotherapy, 2005, Lambrechts, S A G; Aalders, M C G; Van Marle, J
Mechanism based representation of the active site of 5α-reductase (5AR)
score: 0.69177542, Bioorganic & Medicinal Chemistry Letters, 1998, Ahmed, Sabbir; Denison, Sophie
An efficient route to N 6 deoxyadenosine adducts of diol epoxides of carcinogenic polycyclic aromatic hydrocarbons
score: 0.69170242, Bioorganic & Medicinal Chemistry, 1995, Kim, Seong Jin et. al.
Identification of efficient fluorophores for the direct labeling of DNA via rolling circle amplification (RCA) polymerase φ29
score: 0.6916525, European Journal of Medicinal Chemistry, 2010, Linck, Lena; Resch-Genger, Ute
Identification of potent urease inhibitors via ligand- and structure-based virtual screening and in vitro assays
score: 0.69139075, Journal of Molecular Graphics and Modelling, 2010, Khan, Khalid M. et. al.
Theoretical analysis of the electronic properties of the sex pheromone and its analogue derivatives in the female processionary moth Thaumetopoea pytiocampa
score: 0.69134725, Bioorganic & Medicinal Chemistry, 2008, Chamorro, Ester R. et. al.
Inhibition of free radical-mediated oxidation of cellular biomolecules by carboxylated chitooligosaccharides
score: 0.69116341, Bioorganic & Medicinal Chemistry, 2007, Rajapakse, Niranjan et. al.
Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cu (II), Ni (II) and Co (II) complexes
score: 0.69109243, European Journal of Medicinal Chemistry, 2010, Kumar, Gajendra et. al.
Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cu (II), Ni (II) and Co (II) complexes
score: 0.69109243, European Journal of Medicinal Chemistry, 2010, Kumar, Gajendra et. al.
Potentiation of BCNU Cytotoxicity by Molecules Targeting Abasic Lesions in DNA
score: 0.69043591, Bioorganic & Medicinal Chemistry, 2001, Alarcon, Karine et. al.
Automated selection of anti-Protein aptamers
score: 0.6902573, Bioorganic & Medicinal Chemistry, 2001, Cox, J.Colin; Ellington, Andrew D
Phenazine-1-carboxamides: Structure–cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain
score: 0.69016531, Bioorganic & Medicinal Chemistry, 2006, Gamage, Swarna A. et. al.
N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors
score: 0.68896373, European Journal of Medicinal Chemistry, 2000, Martinez, Ana et. al.
Potential of mean force for Syrian hamster prion epitope protein – Monoclonal fab 3f4 antibody interaction studies
score: 0.68860151, European Journal of Medicinal Chemistry, 2009, Wang, Yeng-Tseng et. al.
In vivo and in vitro studies on the stereoselective hydrolysis of tri- and diglycerides by gastric and pancreatic lipases
score: 0.68838816, Bioorganic & Medicinal Chemistry, 1997, Carrière, Frédéric et. al.
Architectural self-construction in nature and chemical synthesis
score: 0.68803837, Bioorganic & Medicinal Chemistry, 2003, Sorensen, Erik J.
Synthesis, characterization and antitumor activity of new type binuclear platinum(II) complexes
score: 0.68767448, European Journal of Medicinal Chemistry, 2009, Zhang, Jinchao et. al.
Novel Wnt antagonists target porcupine and Axin.
score: 0.68743861, Nature chemical biology, 2009, Yeh, Jing-Ruey J; Peterson, Randall T
Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive
score: 0.68726422, Bioorganic & Medicinal Chemistry, 2005, Turner, Jennifer J.; Gerrard, Juliet A.; Hutton, Craig A.
Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element
score: 0.68721784, Bioorganic & Medicinal Chemistry, 1996, Moore, William M. et. al.
Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-Methylcoumarins mediated by the formation of a stable ADP-Fe-Inhibitor mixed ligand complex
score: 0.68709354, Bioorganic & Medicinal Chemistry, 1998, Raj, Hanumantharao G et. al.
Computer-based de novo design of drug-like molecules.
score: 0.68685393, Nature reviews. Drug discovery, 2005, Schneider, Gisbert; Fechner, Uli
Preventing protein secretion with chemical glue.
score: 0.68675542, Nature chemical biology, 2006, Stockwell, Brent R
Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide—a novel topoisomerase II inhibitor
score: 0.68667727, Journal of Molecular Modeling, 2012, Siwek, Agata et. al.
Grand challenge commentary: Informative diagnostics for personalized medicine.
score: 0.68630339, Nature chemical biology, 2010, Bailey, Ryan C
Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1 H)-quinolinones-7-carboxylic acids and their phenacyl esters
score: 0.68594427, European Journal of Medicinal Chemistry, 2006, Soural, Miroslav et. al.
Natural insights for chemical biologists.
score: 0.68581911, Nature chemical biology, 2005, Walsh, Christopher T
The synthesis of [26,27- 11C]dihydroxyvitamin D 3, a tracer for positron emission tomography (PET)
score: 0.68574662, Bioorganic & Medicinal Chemistry, 2001, Bonasera, Thomas A et. al.
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.
score: 0.68550964, Nature chemical biology, 2010, Koketsu, Kento et. al.
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
score: 0.68523736, Nature chemical biology, 2012, Nabel, Christopher S. et. al.
Molybdenocene–oligonucleotide binding study at physiological pH using NMR spectroscopy and cyclic voltammetry
score: 0.68502227, Bioorganic & Medicinal Chemistry, 2006, Vera, José L.; Román, Félix R.; Meléndez, Enrique
A pH sensitive colorometric assay for the high-Throughput screening of enzyme inhibitors and substrates
score: 0.68501755, Bioorganic & Medicinal Chemistry, 2002, Chapman, Eli; Wong, Chi-Huey
Modified iridoid glycosides as anti-implantation agents
score: 0.68457793, Bioorganic & Medicinal Chemistry, 2001, Misra, Anju P et. al.
Curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells
score: 0.68451793, Bioorganic & Medicinal Chemistry, 2003, Gertsch, Jürg et. al.
Design, synthesis and antimicrobial evaluation of novel 2-aryl-thiazolidin-4-one derivatives
score: 0.68441294, Organic and Medicinal Chemistry Letters, 2011, Prasad, Davinder et. al.
Small-molecule switch for zebrafish gene expression.
score: 0.68438663, Nature chemical biology, 2007, Chang, Young-Tae
ATM and MET kinases are synthetic lethal with non-genotoxic activation of p53
score: 0.68414367, Nature chemical biology, 2012, Sullivan, Kelly D. et. al.
Brain-targeted chemical delivery of [Leu 2, Pip 3]-TRH
score: 0.68407157, Bioorganic & Medicinal Chemistry, 2000, Yoon, Sung-Hwa et. al.
Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs
score: 0.68384909, European Journal of Medicinal Chemistry, 2012, Panda, Parthasarathi et. al.
Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines
score: 0.68374408, Bioorganic & Medicinal Chemistry, 2012, Hashimoto, Chie et. al.
Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines
score: 0.68374408, Bioorganic & Medicinal Chemistry, 2012, Hashimoto, Chie et. al.
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
score: 0.68368715, Advanced Drug Delivery Reviews, 2007, De Francesco, Raffaele; Carfí, Andrea
Dipeptide seryl-histidine and related oligopeptides cleave DNA, protein, and a carboxyl ester
score: 0.68364317, Bioorganic & Medicinal Chemistry, 2000, Li, Yunsheng et. al.
Cloning of modular type I polyketide synthase genes from salinomycin producing strain of streptomyces albus
score: 0.6835495, Bioorganic & Medicinal Chemistry, 2003, Izumikawa, Miho et. al.
Mechanistic studies of the rearrangements of steroidal 16,17-ketols and syntheses of 20→16- cis-γ-carbolactones
score: 0.68312522, Bioorganic & Medicinal Chemistry, 1999, Bruttomesso, Andrea C; Doller, Darı́o; Gros, Eduardo G
DNA double helix destabilizing properties of cyclobisintercaland compounds and competition with a single strand binding protein
score: 0.68307197, Bioorganic & Medicinal Chemistry, 2000, Teulade-Fichou, Marie-Paule et. al.
Formation of a fairly stable diazoate intermediate of 5-methyl-2′-deoxycytidine by HNO 2 and NO, and its implication to a novel mutation mechanism in CpG site
score: 0.68306092, Bioorganic & Medicinal Chemistry, 2002, Suzuki, Toshinori et. al.
Biomimetic degradation of lignin and lignin model compounds by synthetic anionic and cationic water soluble manganese and iron porphyrins
score: 0.68298113, Bioorganic & Medicinal Chemistry, 1999, Crestini, Claudia et. al.
Structure-Based Design of Ricin Inhibitors
score: 0.68276269, Toxins, 2011, Jasheway, Karl et. al.
Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain
score: 0.68263732, Bioorganic & Medicinal Chemistry, 2012, Akdemir, Atilla et. al.
Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates
score: 0.6826124, European Journal of Medicinal Chemistry, 2006, Zhao, Xiangguo; Tao, Xinyi; Wei, Dongzhi; Song, Qingxun
Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and π-acceptors
score: 0.68248776, European Journal of Medicinal Chemistry, 2010, Siddiqui, Farhan Ahmed et. al.
Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and π-acceptors
score: 0.68248776, European Journal of Medicinal Chemistry, 2010, Siddiqui, Farhan Ahmed et. al.
Natural strategies for the spatial optimization of metabolism in synthetic biology.
score: 0.68225784, Nature chemical biology, 2012, Agapakis, Christina M; Boyle, Patrick M; Silver, Pamela A
Novel metal based anti-tuberculosis agent: Synthesis, characterization, catalytic and pharmacological activities of copper complexes
score: 0.68204861, European Journal of Medicinal Chemistry, 2012, Joseph, J.; Nagashri, K.; Janaki, G. Boomadevi
Incremental truncation as a strategy in the engineering of novel biocatalysts
score: 0.6819707, Bioorganic & Medicinal Chemistry, 1999, Ostermeier, Marc; Nixon, Andrew E; Benkovic, Stephen J
Grand challenge commentary: Chemical transdifferentiation and regenerative medicine.
score: 0.68172047, Nature chemical biology, 2010, Wagner, Bridget K
Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.
score: 0.68162126, Bioorganic & Medicinal Chemistry, 2003, Corea, Gabriella et. al.
Synthesis and reactivities of 3-Indocyanine-green-acyl-1,3-thiazolidine-2-thione (ICG-ATT) as a new near-infrared fluorescent-labeling reagent
score: 0.6813494, Bioorganic & Medicinal Chemistry, 1998, Hirata, Terukage et. al.
Cardiovascular hybrid drugs: new benzazepinone derivatives as bradycardic agents endowed with selective β 1-Non-competitive antagonism
score: 0.68131432, Bioorganic & Medicinal Chemistry, 2003, Bisi, Alessandra et. al.
HIV protease inhibitor HOE/BAY 793, structure-activity relationships in a series of C 2-symmetric diols
score: 0.68120059, Bioorganic & Medicinal Chemistry, 1995, Budt, Karl-Heinz et. al.
Design and synthesis of new mitochondrial cytotoxin N-thiadiazolylanilines that inhibit tumor cell growth
score: 0.68080846, Bioorganic & Medicinal Chemistry, 1996, Hori, Hitoshi et. al.
Major sperm protein as a diagnostic antigen for onchocerciasis
score: 0.68080416, Bioorganic & Medicinal Chemistry, 2008, Park, Junguk; Dickerson, Tobin J.; Janda, Kim D.
Combined 3D-QSAR modeling and molecular docking study on 1,4-dihydroindeno[1,2-c]pyrazoles as VEGFR-2 kinase inhibitors
score: 0.68047431, Journal of Molecular Graphics and Modelling, 2010, Zeng, Huahui; Zhang, Huabei
α-Ketoamide Phe—Pro isostere as a new core structure for the inhibition of HIV protease
score: 0.6802684, Bioorganic & Medicinal Chemistry, 1994, Munoz, Benito; Giam, Chou-Zen; Wong, Chi-Huey
Spectroscopic properties of pyrene-containing DNA mimics
score: 0.68024846, Bioorganic & Medicinal Chemistry, 2008, Samain, Florent et. al.
Lipase-catalysed acylation of prostanoids
score: 0.68017445, Bioorganic & Medicinal Chemistry Letters, 1999, Parve, Omar et. al.
A versatile and convenient protocol for the stereocontrolled synthesis of olefinic insect pheromones
score: 0.67957791, Bioorganic & Medicinal Chemistry, 1996, Vasil'ev, Andrei A. et. al.
Photo-induced anticancer activity of polypyridyl platinum(II) complexes
score: 0.67925995, European Journal of Medicinal Chemistry, 2012, Maity, Basudev et. al.
Benzimidazole condensed ring systems. XI. Synthesis of some substituted cycloalkyl pyrido[1,2-a]benzimidazoles with anticipated antineoplastic activity # # This work was partly presented in the 6th Ibn Sina International Conference on pure and applied Heterocyclic Chemistry, December, 1997. For part X, see ref. [4]
score: 0.67902078, European Journal of Medicinal Chemistry, 1999, Badawey, El-Sayed A.M.; Kappe, Thomas
Bicyclic [ b]-heteroannulated pyridazine derivatives—II. Structure-activity relationships in the 6-aryltriazolo-[4,3- b]pyridazine ligands of the benzodiazepine receptor
score: 0.67893093, Bioorganic & Medicinal Chemistry, 1994, Karolak-Wojciechowska, Janina et. al.
Dihydrofolate reductase and cell growth activity inhibition by the β-carboline-benzoquinolizidine plant alkaloid deoxytubulosine from Alangium lamarckii: Its potential as an antimicrobial and anticancer agent
score: 0.67860704, Bioorganic & Medicinal Chemistry, 1999, Rao, Kothapalli Narasimha; Venkatachalam, Sekharipuram Raman
Glycosidase inhibitors of gem-diamine 1- N-iminosugars
score: 0.67830779, Bioorganic & Medicinal Chemistry, 2001, Kondo, Ken-ichiro et. al.
Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide
score: 0.67786335, Bioorganic & Medicinal Chemistry, 2000, Saotome, Chikako et. al.
Design and synthesis of a series of indole glycoprotein IIb/IIIa inhibitors
score: 0.67783031, European Journal of Medicinal Chemistry, 2002, Grumel, Valérie et. al.
alternative heterocycles for dna recognition: a 3-pyrazole/pyrrole pair specifies for g·c base pairs
score: 0.6775674, Bioorganic & Medicinal Chemistry, 2000, Zhan, Zheng-Yun J; Dervan, Peter B
Chemo-enzymatic fluorination of unactivated organic compounds.
score: 0.67727726, Nature chemical biology, 2009, Rentmeister, Andrea; Arnold, Frances H; Fasan, Rudi
Anti-oxidant activities of curcumin and related enones
score: 0.67714759, Bioorganic & Medicinal Chemistry, 2005, Weber, Waylon M. et. al.
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability.
score: 0.67678901, ChemMedChem, 2009, Vacondio, Federica et. al.
Analogue-based approaches in anti-cancer compound modelling: the relevance of QSAR models
score: 0.67658952, Organic and Medicinal Chemistry Letters, 2011, Bohari, Mohammed Hussaini et. al.
Towards oligosaccharide libraries: A study of the random galactosylation of unprotected N-acetylglucosamine
score: 0.67608237, Bioorganic & Medicinal Chemistry, 1996, Ding, Yili; Labbe, Jill; Kanie, Osamu; Hindsgaul, Ole
RNA structure: Riboswitch strikes a chord.
score: 0.67606022, Nature chemical biology, 2011, Dann, Charles E
Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
score: 0.67595276, Bioorganic & Medicinal Chemistry, 2002, Jeong, Ha-Won et. al.
Design, synthesis, and structure–activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands
score: 0.67563641, Bioorganic & Medicinal Chemistry, 2004, Okubo, Taketoshi et. al.
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations
score: 0.67517525, Bioorganic & Medicinal Chemistry, 1996, Ghelli, Stefano et. al.
Fluorescent castasterone reveals BRI1 signaling from the plasma membrane.
score: 0.67500754, Nature chemical biology, 2012, Irani, Niloufer G et. al.
Phage selection for site-specific incorporation of unnatural amino acids into proteins in vivo
score: 0.6749233, Bioorganic & Medicinal Chemistry, 2001, Pastrnak, Miro; Schultz, Peter G.
Mechanism of the Class I KDPG aldolase
score: 0.67466299, Bioorganic & Medicinal Chemistry, 2006, Fullerton, Stephen W.B. et. al.
Hemisynthesis and antiproliferative properties of mono-[O-(14-benzoylaconine-8-yl)]esters and bis-[O-(14-benzoylaconine-8-yl)]esters
score: 0.67451831, European Journal of Medicinal Chemistry, 2012, Chodoeva, Ainura et. al.
The EVA spectral descriptor 1 Current address: Synt:em, Parc Scientifique G.Besse, 30000 Nimes, France
score: 0.67394575, European Journal of Medicinal Chemistry, 2000, Turner, David B.; Willett, Peter
Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways.
score: 0.67359334, Nature chemical biology, 2011, Bond-Watts, Brooks B et. al.
The pheromone system of the male danaine butterfly, Idea leuconoe
score: 0.6734932, Bioorganic & Medicinal Chemistry, 1996, Schulz, S.; Nishida, R.
Synthesis, characterization and biological properties of a novel copper complex
score: 0.67232637, European Journal of Medicinal Chemistry, 2003, Majumder, Surajit et. al.
Stereochemistry of yeast Δ 24-sterol methyl transferase
score: 0.6723155, Bioorganic & Medicinal Chemistry, 1997, Acuna-Johnson, Adriana P. et. al.
LC/MS analysis of cellular RNA reveals NAD-linked RNA
score: 0.67148535, Nature chemical biology, 2009, Chen, Y. Grace et. al.
Isolation of quercetin's salts and studies of their physicochemical properties and antioxidant relationships
score: 0.67134724, Bioorganic & Medicinal Chemistry, 2004, Milane, Hadi A. et. al.
Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/c 17,20-lyase and 5α-reductase
score: 0.67111024, Bioorganic & Medicinal Chemistry, 1998, Ling, Yang-zhi et. al.
Lipase catalysed synthesis of optically enriched α-haloamides
score: 0.67099035, Bioorganic & Medicinal Chemistry, 2001, Azim, Abul et. al.
Choline kinase inhibitory effect and antiproliferative activity of new 1,1′,1″-(benzene-1,3,5-triylmethylene)tris{4-[(disubstituted)amino]pyridinium} tribromides
score: 0.67095081, European Journal of Medicinal Chemistry, 2003, Conejo-Garcı́a, Ana et. al.
Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine
score: 0.67058587, European Journal of Medicinal Chemistry, 2001, Matosiuk, Dariusz et. al.
Cocaine detoxification by combinatorially substituted β-Cyclodextrin libraries
score: 0.66999903, Bioorganic & Medicinal Chemistry, 2002, Yu, Jiaxin et. al.
Synthesis and characterization of a 68Ga-labeled N-(2-diethylaminoethyl)benzamide derivative as potential PET Probe for malignant melanoma
score: 0.66918382, Bioorganic & Medicinal Chemistry, 2012, Kim, Hee-Jung et. al.
Discovery of Glycosyltransferases Using Carbohydrate Arrays and Mass Spectrometry
score: 0.66912771, Nature chemical biology, 2012, Ban, Lan et. al.
Synthesis and structural studies of asparagine-modified 2-deoxy-α- N-glycopeptides associated with the renin-Angiotensin system
score: 0.66885777, Bioorganic & Medicinal Chemistry, 1994, Laupichle, Lothar; Sowa, Carsten Endres; Thiem, Joachim
Hydroquinone, a control agent of agglutination and adherence of Streptococcus mutans induced by sucrose
score: 0.66877847, Bioorganic & Medicinal Chemistry, 2004, Himejima, Masaki; Nihei, Ken-ichi; Kubo, Isao
Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo- l-Trp- l-Pro
score: 0.66858194, Bioorganic & Medicinal Chemistry, 2000, Sanz-Cervera, Juan F et. al.
Cloning and mutagenesis of the p110α subunit of human phosphoinositide 3′-hydroxykinase
score: 0.66834165, Bioorganic & Medicinal Chemistry, 1997, Stirdivant, Steven M. et. al.
Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling
score: 0.6678486, Bioorganic & Medicinal Chemistry, 2012, McDonnell, Mark E. et. al.
Turning down tau phosphorylation.
score: 0.66765591, Nature chemical biology, 2008, Fischer, Peter M
Forging synergies in drug discovery.
score: 0.66709285, Nature chemical biology, 2008,
Synthesis of 13C labelled daidzein and formononetin
score: 0.66703394, Bioorganic & Medicinal Chemistry Letters, 1998, Whalley, Jacqueline L.; Bond, Timothy J.; Botting, Nigel P.
Chemical sensing of DNT by engineered olfactory yeast strain.
score: 0.66669886, Nature chemical biology, 2007, Radhika, Venkat et. al.
Stapled peptides: Magic bullets in nature's arsenal.
score: 0.66654317, Nature chemical biology, 2010, Kritzer, Joshua A
Microbial metabolic exchange-the chemotype-to-phenotype link.
score: 0.66633203, Nature chemical biology, 2011, Phelan, Vanessa V et. al.
Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase – mimetic activities
score: 0.66608919, European Journal of Medicinal Chemistry, 2010, Abuhijleh, A. Latif; Khalaf, Juhienah
Metals in chemical biology.
score: 0.66514002, Nature chemical biology, 2008,
Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in human immunodeficiency virus-infected patients.
score: 0.66512036, Antimicrobial agents and chemotherapy, 1999, Cundy, K C et. al.
Cross-linking of proteins by maillard processes—characterization and detection of a lysine-arginine cross-link derived from d-glucose
score: 0.6644573, Bioorganic & Medicinal Chemistry, 1999, Lederer, Markus O; Bühler, Holger P
Corrigendum to “The structure of McN-5652” [Bioorg. Med. Chem. 9 (2001) 2105]
score: 0.66438521, Bioorganic & Medicinal Chemistry, 2002, Schulze, Oliver et. al.
Vibrational circular dichroism spectroscopy of selected oligopeptide conformations
score: 0.66400022, Bioorganic & Medicinal Chemistry, 1999, Keiderling, Timothy A et. al.
Structure-based drug design meets the ribosome
score: 0.66364511, Biochemical Pharmacology, 2006, Franceschi, François; Duffy, Erin M.
Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus
score: 0.66344273, Bioorganic & Medicinal Chemistry, 2012, Imamura, Masakazu et. al.
Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus
score: 0.66344273, Bioorganic & Medicinal Chemistry, 2012, Imamura, Masakazu et. al.
Accumulation of norfloxacin by Mycobacterium aurum and Mycobacterium smegmatis.
score: 0.66328749, Antimicrobial agents and chemotherapy, 1998, Williams, K J; Chung, G A; Piddock, L J
Focus on chemical systems biology. In this issue.
score: 0.66324665, Nature chemical biology, 2008, Donner, Amy; Goodman, Catherine; Kotz, Joanne
Construction of peptide conjugates with peptide nucleic acids containing an anthracene probe and their interactions with DNA
score: 0.66312649, Bioorganic & Medicinal Chemistry, 2001, Balasundaram, Ganesan et. al.
The discovery and structure—activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ET B receptor
score: 0.66270864, Bioorganic & Medicinal Chemistry, 1998, Chan, Ming Fai et. al.
Mass transport kinetics of the DNA-binding dye Hoechst-33342 into bovine spermatozoa
score: 0.66262191, Bioorganic & Medicinal Chemistry, 2007, Weisenfeld, Robert B.
Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
score: 0.66243593, Chemmedchem, 2011, Su, Xiangdong et. al.
Chemical crosshairs on the central dogma.
score: 0.66235596, Nature chemical biology, 2007, Ansari, Aseem Z
Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography
score: 0.66230776, Bioorganic & Medicinal Chemistry, 2010, Prinsen, Kristof et. al.
A direct method for the formation of peptide and carbohydrate dendrimers
score: 0.66229151, Bioorganic & Medicinal Chemistry Letters, 1999, Mitchell, Jeffrey P. et. al.
IKK β inhibitor identification: a multi-filter driven novel scaffold
score: 0.66226322, BMC Bioinformatics, 2010, Nagarajan, Shanthi et. al.
Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities.
score: 0.66202543, Antimicrobial agents and chemotherapy, 2005, Shah, Vishal et. al.
Reduction of bicyclo[3.3.1]nonane-2,8-diones with baker's yeast
score: 0.66123588, Bioorganic & Medicinal Chemistry, 1994, Mori, Kenji; Takayama, Shuichi; Kido, Masani
A microgonotropen branched decaaza decabutylamine and its DNA and DNA/transcription factor interactions
score: 0.66116337, Bioorganic & Medicinal Chemistry, 1997, Bruice, Thomas C. et. al.
An effective docking strategy for virtual screening based on multi-objective optimization algorithm
score: 0.66115725, BMC Bioinformatics, 2009, Li, Honglin et. al.
Stereoselective disposition of sulbenicillin in humans.
score: 0.66107606, Antimicrobial agents and chemotherapy, 1998, Itoh, T et. al.
In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer's disease
score: 0.66074323, Theoretical Biology & Medical Modelling, 2010, Ul-Haq, Zaheer et. al.
Hydration free energy a fragmental model and drug design
score: 0.66060372, European Journal of Medicinal Chemistry, 2002, Pèpe, Gérard et. al.
Synthesis and antiproliferative activity of some variously substituted acridineand azacridine derivatives
score: 0.66024167, European Journal of Medicinal Chemistry, 2000, Ferlin, Maria Grazia et. al.
Chemoenzymatic synthesis of an unnatural tetramethyl cobalt corphinoid 1 Dedicated to the memory of Sir Derek Barton. 1
score: 0.66012759, Bioorganic & Medicinal Chemistry, 1999, Santander, Patricio J.; Stolowich, Neal J.; Scott, A.Ian
Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA
score: 0.65958853, European Journal of Medicinal Chemistry, 2012, Zhu, Qinchang et. al.
Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA
score: 0.65958853, European Journal of Medicinal Chemistry, 2012, Zhu, Qinchang et. al.
Streamlining lead discovery by aligning in silico and high-throughput screening
score: 0.65922298, Current Opinion in Chemical Biology, 2006, Davies, John W; Glick, Meir; Jenkins, Jeremy L
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.
score: 0.65918335, Nature chemical biology, 2012, Blättermann, Stefanie et. al.
Synthesis and cytotoxic evaluation of α-methylene-γ-butyrolactone bearing naphthalene and naphtho[2,1- b]furan derivatives
score: 0.65903494, European Journal of Medicinal Chemistry, 2002, Lee, Kuan-Han; Huang, Bor-Ruey
Active conformation of some arylpiperazine postsynaptic 5-HT 1A receptor antagonists
score: 0.65882855, European Journal of Medicinal Chemistry, 2002, Paluchowska, Maria Halina et. al.
AMPA receptors and synaptic plasticity: a chemist's perspective.
score: 0.65850499, Nature chemical biology, 2010, Fleming, James J; England, Pamela M
3D-QSAR and Molecular Docking Studies on Fused Pyrazoles as p38α Mitogen-Activated Protein Kinase Inhibitors
score: 0.65846491, International Journal of Molecular Sciences, 2010, Lan, Ping; Huang, Zhi-Jian; Sun, Jun-Rong; Chen, Wei-Min
Tc and Re Chelates of 8α-Amino-6-methyl-ergoline: Synthesis and Affinity to the Dopamine D 2 Receptor
score: 0.65820207, Bioorganic & Medicinal Chemistry, 2002, Spies, H et. al.
Hemisynthesis and antiproliferative properties of mono-[O-(14-benzoylaconine-8-yl)]esters and bis-[O-(14-benzoylaconine-8-yl)]esters
score: 0.65815076, European Journal of Medicinal Chemistry, 2012, Chodoeva, Ainura et. al.
Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones
score: 0.65765031, European Journal of Medicinal Chemistry, 2000, Macchia, Bruno et. al.
Targeting of polyplex to human hepatic cells by bio-nanocapsules, hepatitis B virus surface antigen L protein particles
score: 0.65763276, Bioorganic & Medicinal Chemistry, 2012, Somiya, Masaharu et. al.
Targeting of polyplex to human hepatic cells by bio-nanocapsules, hepatitis B virus surface antigen L protein particles
score: 0.65763276, Bioorganic & Medicinal Chemistry, 2012, Somiya, Masaharu et. al.
Targeting of polyplex to human hepatic cells by bio-nanocapsules, hepatitis B virus surface antigen L protein particles
score: 0.65763276, Bioorganic & Medicinal Chemistry, 2012, Somiya, Masaharu et. al.
DNA-catalyzed sequence-specific hydrolysis of DNA.
score: 0.6575164, Nature chemical biology, 2009, Chandra, Madhavaiah; Sachdeva, Amit; Silverman, Scott K
Malleable machines take shape in eukaryotic transcriptional regulation.
score: 0.65723604, Nature chemical biology, 2008, Fuxreiter, Monika et. al.
β-Lactam synthon-interceded diastereoselective synthesis of functionalized octahydroindole-based molecular scaffolds and their in vitro cytotoxic evaluation
score: 0.65712277, European Journal of Medicinal Chemistry, 2012, Singh, Pardeep et. al.
β-Lactam synthon-interceded diastereoselective synthesis of functionalized octahydroindole-based molecular scaffolds and their in vitro cytotoxic evaluation
score: 0.65712277, European Journal of Medicinal Chemistry, 2012, Singh, Pardeep et. al.
Novel Tn antigen-containing neoglycopeptides: synthesis and evaluation as anti tumor vaccines
score: 0.65711735, Bioorganic & Medicinal Chemistry, 2002, Cipolla, Laura et. al.
Introduction of a nitroxide group on position 2 of 9-phenoxyacridine: Easy access to spin labelled DNA-binding conjugates
score: 0.65710605, Bioorganic & Medicinal Chemistry Letters, 1998, Belmont, Philippe et. al.
Syntheses and hydrolysis of basic and dibasic ampicillin esters tailored for intracellular accumulation
score: 0.65691058, Bioorganic & Medicinal Chemistry, 2001, Paternotte, Isabelle et. al.
A structure–activity relationship study on position-2 of the Gα s C-terminal peptide able to inhibit G s activation by A 2A adenosine receptor
score: 0.65690159, European Journal of Medicinal Chemistry, 2003, Grieco, Paolo et. al.
Using Simple Donors to Drive the Equilibria of Glycosyltransferase-Catalyzed Reactions
score: 0.65654679, Nature chemical biology, 2011, Gantt, Richard W. et. al.
Significance of chirality in pheromone science
score: 0.65592955, Bioorganic & Medicinal Chemistry, 2007, Mori, Kenji
Combined 3D-QSAR, Molecular Docking and Molecular Dynamics Study on Derivatives of Peptide Epoxyketone and Tyropeptin-Boronic Acid as Inhibitors Against the β5 Subunit of Human 20S Proteasome
score: 0.65579381, International Journal of Molecular Sciences, 2011, Liu, Jianling et. al.
New carbamate supports for the preparation of 3′-amino-modified oligonucleotides
score: 0.6556021, Bioorganic & Medicinal Chemistry, 1996, Aviñó, Anna et. al.
Protonated forms of poly[d(G-C)] and poly(dG).poly(dC) and Their interaction with berberine
score: 0.65558356, Bioorganic & Medicinal Chemistry, 2003, Kumar, Gopinatha Suresh et. al.
Discovery of Ipragliflozin (ASP1941): A Novel C-glucoside with Benzothiophene Structure as a Potent and Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes Mellitus
score: 0.65556457, Bioorganic & Medicinal Chemistry, 2012, Imamura, Masakazu et. al.
Chemical biology in China takes on signal transduction.
score: 0.65547615, Nature chemical biology, 2008, Jiang, Hualiang et. al.
10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase
score: 0.65546463, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L. et. al.
Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules
score: 0.6554246, Bioorganic & Medicinal Chemistry, 2001, Boger, Dale L; Tse, Winston C
Syntheses and biological activities of chemically stable prostacyclin mimics with cis-bicyclo[4.3.0]nonene ring system: The novel homoisocarbacyclin analogues
score: 0.65510057, Bioorganic & Medicinal Chemistry, 1993, Narita, Sen-ichi et. al.
Selection of deoxyribozyme ligases that catalyze the formation of an unnatural internucleotide linkage
score: 0.65499616, Bioorganic & Medicinal Chemistry, 2001, Levy, Matthew; Ellington, Andrew D
Ending the prolonged life of cancer cells.
score: 0.65494284, Nature chemical biology, 2005, Wagner, Gerhard
Docking-enabled pharmacophore model for histone deacetylase 8 inhibitors and its application in anti-cancer drug discovery
score: 0.65490042, Journal of Molecular Graphics and Modelling, 2010, Sundarapandian, Thangapandian et. al.
Synthesis of enantiopure Δ 2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human β-adrenergic receptor subtypes
score: 0.65470999, Bioorganic & Medicinal Chemistry, 2006, Dallanoce, Clelia et. al.
Theoretical study revealing the functioning of a novel combination of catalytic motifs in histone deacetylase
score: 0.65431463, Bioorganic & Medicinal Chemistry, 2005, Vanommeslaeghe, K. et. al.
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase
score: 0.65410275, European Journal of Medicinal Chemistry, 2012, Breda, Ardala et. al.
Retraction notice to “Proton-pumping-ATPase-targeted antifungal activity of cinnamaldehyde based sulfonyl tetrazoles” [Eur. J. Med. Chem. 48 (2012) 363–370]
score: 0.65400753, European Journal of Medicinal Chemistry, 2012, Shreaz, Sheikh et. al.
Retraction notice to “Proton-pumping-ATPase-targeted antifungal activity of cinnamaldehyde based sulfonyl tetrazoles” [Eur. J. Med. Chem. 48 (2012) 363–370]
score: 0.65400753, European Journal of Medicinal Chemistry, 2012, Shreaz, Sheikh et. al.
Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity
score: 0.65333103, Chemistry Central Journal, 2012, Aboul-Fadl, Tarek et. al.
5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety
score: 0.65323155, DARU Journal of Pharmaceutical Sciences, 2013, Nadri, Hamid et. al.
Local intersection volume: a new 3D descriptor applied to develop a 3D-QSAR pharmacophore model for benzodiazepine receptor ligands
score: 0.65295406, European Journal of Medicinal Chemistry, 2002, Verli, Hugo et. al.
Solubility of nicotinic acid in polyamidoamine dendrimer solutions
score: 0.6526672, European Journal of Medicinal Chemistry, 2005, Yiyun, Cheng; Tongwen, Xu
Activation mechanism for N-nitroso- N-methylbutylamine mutagenicity by radical species
score: 0.65262237, Bioorganic & Medicinal Chemistry, 2010, Tsutsumi, Nozomi; Inami, Keiko; Mochizuki, Masataka
Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase
score: 0.65249534, Bioorganic & Medicinal Chemistry, 2001, Bounaga, Sakina et. al.
Excitatory amino acid receptor ligands: Asymmetric synthesis, absolute stereochemistry and pharmacology of ( R)- and ( S)-homoibotenic acid
score: 0.6519625, Bioorganic & Medicinal Chemistry, 1995, Bischoff, F. et. al.
Database mining applied to central nervous system (CNS) activity
score: 0.65165037, European Journal of Medicinal Chemistry, 2001, Pintore, Marco et. al.
Signaling: An oxysterol ligand for Smoothened.
score: 0.65127299, Nature chemical biology, 2012, Sharpe, Hayley J; de Sauvage, Frederic J
Structure–activity relationships on adrenoceptors and imidazoline-preferring binding sites (I 1,2-PBSs). Part 1: weak intramolecular H-bond and conformational flexibility in a new I 1-PBS-selective imidazoline analogue, trans1-(4′,5′-dihydro-1′ H-imidazol-2′-yl)methyl-2-hydroxyindane (PMS 952)
score: 0.65122179, Bioorganic & Medicinal Chemistry, 2000, Ye, H.F; Dive, G; Dehareng, D; Heymans, F; Godfroid, J.J
n → π * Interactions in Proteins
score: 0.65085303, Nature chemical biology, 2010, Bartlett, Gail J. et. al.
Phospholipid-Bound Molecular Rotors: Synthesis and Characterization
score: 0.65082504, Bioorganic & Medicinal Chemistry, 2002, Haidekker, Mark A. et. al.
Glucosinolate engineering identifies a gamma-glutamyl peptidase.
score: 0.65074193, Nature chemical biology, 2009, Geu-Flores, Fernando et. al.
Sulfonates-PMMA nanoparticles conjugates: A versatile system for multimodal application
score: 0.65059665, Bioorganic & Medicinal Chemistry, 2012, Monasterolo, Claudio et. al.
Sulfonates-PMMA nanoparticles conjugates: A versatile system for multimodal application
score: 0.65059665, Bioorganic & Medicinal Chemistry, 2012, Monasterolo, Claudio et. al.
Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides
score: 0.65031001, Bioorganic & Medicinal Chemistry, 2000, Arimondo, Paola B et. al.
Synthesis, muscarinic blocking activity and molecular modeling studies of 4-DAMP-related compounds
score: 0.65018488, Bioorganic & Medicinal Chemistry, 1995, Recanatini, Maurizio et. al.
Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors
score: 0.64991355, Journal of Molecular Graphics and Modelling, 2010, Zaheer-ul-Haq, et. al.
5-(5-(6-[11C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole as a potential PET radioligand for imaging cerebral α7-nAChR in mice
score: 0.64976405, Bioorganic & Medicinal Chemistry, 2012, Gao, Yongjun et. al.
New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives
score: 0.64971006, Bioorganic & Medicinal Chemistry Letters, 2004, Lee, Yan et. al.
Toward small-molecule agonists of TNF receptors.
score: 0.64969192, Nature chemical biology, 2005, Hymowitz, Sarah G; Ashkenazi, Avi
3-Chloropropanoic acid (UMB66): a ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group
score: 0.64887587, Bioorganic & Medicinal Chemistry, 2004, Macias, Alba T et. al.
Synthesis and antimalarial activities of some furoxan sulfones and related furazans
score: 0.64875924, European Journal of Medicinal Chemistry, 2005, Galli, Ubaldina et. al.
Mechanism of amphotericin B resistance in Leishmania donovani promastigotes.
score: 0.64831777, Antimicrobial agents and chemotherapy, 1998, Mbongo, N; Loiseau, P M; Billion, M A; Robert-Gero, M
Selective photocleavage of single-stranded nucleic acids by cyclobisintercaland molecules
score: 0.64767438, Bioorganic & Medicinal Chemistry Letters, 1998, Blacker, A.John et. al.
Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai
score: 0.64732939, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Eun La et. al.
Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai
score: 0.64732939, Bioorganic & Medicinal Chemistry Letters, 2012, Kim, Eun La et. al.
Synthesis and β-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine:potential antihypertensive agents – Part IX
score: 0.6471442, European Journal of Medicinal Chemistry, 2000, Ferrarini, Pier Luigi et. al.
Oligonucleotides containing a lysine residue as 3′–3′ junction for alternate strand triple helix formation
score: 0.64690878, Bioorganic & Medicinal Chemistry, 2001, Barone, Guido et. al.
Conjugating folic acid to gold nanoparticles through glutathione for targeting and detecting cancer cells
score: 0.64672153, Bioorganic & Medicinal Chemistry, 2010, Zhang, Zhaowu et. al.
Drugs in action.
score: 0.64646024, Nature chemical biology, 2008, Eggert, Ulrike S; Superti-Furga, Giulio
The chemistry/biology interface
score: 0.6462322, Bioorganic & Medicinal Chemistry, 2012, Osada, Hiroyuki; Muroi, Makoto; Yoshida, Minoru
Intramolecular orbital alignments in serine protease/protein inhibitor complexes
score: 0.64574717, Bioorganic & Medicinal Chemistry, 2004, Fan, Yun-Hua; Grégoire, Claire-Anne; Haseltine, John
Synthesis and D 2-like binding affinity of new derivatives of N-(1-ethyl-2-pyrrolidinylmethyl)-4,5-dihydro-1 H-benzo[ g]indole-3-carboxamide and related 4 H-[1]benzothiopyrano[4,3- b]pyrrole and 5,6-dihydro-4 H-benzo[6,7]cyclohepta[ b]pyrrole-3-carboxamide analogues
score: 0.64560814, Bioorganic & Medicinal Chemistry, 2002, Pinna, Gérard A et. al.
A synergistic small-molecule combination directly eradicates diverse prion strain structures.
score: 0.64516441, Nature chemical biology, 2009, Roberts, Blake E et. al.
Derivatives of 4,6-diamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3- a]quinoxalin-2 H-1-one: potential antagonist ligands for imaging the A 2A adenosine receptor by positron emission tomography (PET)
score: 0.64464734, European Journal of Medicinal Chemistry, 2005, Holschbach, Marcus H. et. al.
Inhibitors paradoxically prime kinases.
score: 0.64455854, Nature chemical biology, 2009, Frye, Stephen V; Johnson, Gary L
Natural product glycorandomization
score: 0.64448189, Bioorganic & Medicinal Chemistry, 2004, Yang, Jie et. al.
Edible Myrciaria vexator Fruits: Bioactive Phenolics for Potential COPD Therapy
score: 0.64408052, Bioorganic & Medicinal Chemistry, 2012, Dastmalchi, Keyvan et. al.
The Process of Structure-Based Drug Design
score: 0.64271464, Chemistry & Biology, 2003, Anderson, Amy C.
Cytotoxic activity of new cerium (III) complexes of bis-coumarins
score: 0.64262185, European Journal of Medicinal Chemistry, 2005, Kostova, Irena et. al.
Stereochemistry of cleavage of internucleotide bonds by Serratia marcescens endonuclease
score: 0.64259583, Bioorganic & Medicinal Chemistry, 2001, Koziołkiewicz, Maria et. al.
Combination chemical genetics.
score: 0.64205675, Nature chemical biology, 2008, Lehár, Joseph et. al.
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
score: 0.64042291, Nature chemical biology, 2011, Bieschke, Jan et. al.
Effect of Aryl Ring Fluorination on the Antibacterial Properties of C 4 Aryl-Substituted N-Methylthio β-Lactams
score: 0.64040173, Bioorganic & Medicinal Chemistry, 2003, Long, Timothy E et. al.
Synthesis and structure–affinity relationships of 1,3,5-alkylsubstituted cyclohexylamines binding at NMDA receptor PCP site
score: 0.64030309, European Journal of Medicinal Chemistry, 2000, Jirgensons, Aigars et. al.
CH/π Interactions as demonstrated in the crystal structure of guanine-nucleotide binding proteins, Src homology-2 domains and human growth hormone in complex with their specific ligands
score: 0.64003582, Bioorganic & Medicinal Chemistry, 1998, Umezawa, Yoji; Nishio, Motohiro
New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from ( R)- and ( S)-proline and homologous pyrrolidine-2-alkanoic acids
score: 0.63996834, European Journal of Medicinal Chemistry, 2006, Fülep, Günther H. et. al.
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.
score: 0.63952151, Nature chemical biology, 2012, Hantschel, Oliver et. al.
Efficacy validation of synthesized retinol derivatives In vitro: stability, toxicity, and activity
score: 0.63950295, Bioorganic & Medicinal Chemistry, 2003, Han, Hye-Sook et. al.
N-Cubylmethyl substituted morphinoids as novel narcotic antagonists
score: 0.63944055, Bioorganic & Medicinal Chemistry, 1996, Cheng, Chen-Yu et. al.
Structure–activity relationships of sandalwood odorants: synthesis and odor of tricyclo β-santalol
score: 0.63912061, European Journal of Medicinal Chemistry, 2004, Buchbauer, Gerhard et. al.
Nox2 redox signaling maintains essential cell populations in the brain
score: 0.63899777, Nature chemical biology, 2010, Dickinson, Bryan C et. al.
The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: A concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives
score: 0.63888516, European Journal of Medicinal Chemistry, 2012, Agelis, George et. al.
Synthesis and biological evaluation of novel lipid A antagonists
score: 0.63839628, Bioorganic & Medicinal Chemistry, 2006, Peri, Francesco et. al.
Stabilization of a C 7 equatorial gamma turn in DMSO- d 6 by a ditryptophan crosslink
score: 0.63800715, Bioorganic & Medicinal Chemistry, 1998, Stachel, Shawn J. et. al.
Directed evolution drives the next generation of biocatalysts.
score: 0.63702794, Nature chemical biology, 2009, Turner, Nicholas J
Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.
score: 0.63701161, Nature chemical biology, 2008, Neumann, Heinz; Peak-Chew, Sew Y; Chin, Jason W
Combined 3D-QSAR and Docking Modelling Study on Indolocarbazole Series Compounds as Tie-2 Inhibitors
score: 0.63687015, International Journal of Molecular Sciences, 2011, Tian, Yuanxin et. al.
Thermal stability of triple helical DNAs containing 2′-deoxyinosine and 2′-deoxyxanthosine
score: 0.63660076, Bioorganic & Medicinal Chemistry, 2004, Ueno, Yoshihito; Shibata, Aya; Matsuda, Akira; Kitade, Yukio
Chemoenzymatic synthesis of PSGL-1 glycopeptides: sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan
score: 0.63632842, Bioorganic & Medicinal Chemistry, 2000, Koeller, Kathryn M; Smith, Mark E.B; Wong, Chi-Huey
A mammalian functional-genetic approach to characterizing cancer therapeutics.
score: 0.63629961, Nature chemical biology, 2011, Jiang, Hai et. al.
I 2-Imidazoline Binding Site Affinity of a Structurally Different Type of Ligands
score: 0.63615317, Bioorganic & Medicinal Chemistry, 2002, Dardonville, Christophe et. al.
Solid-phase stereoselective synthesis of 2′- O-methyl-oligoribonucleoside phosphorothioates using nucleoside bicyclic oxazaphospholidines
score: 0.63608772, Bioorganic & Medicinal Chemistry Letters, 1998, Guo, MaoJun et. al.
The design of dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes
score: 0.63607986, Bioorganic & Medicinal Chemistry, 1996, Horwell, David C. et. al.
Reactions of some cyclopentenones with selected cysteine derivatives and biological activities of the product thioethers
score: 0.63602951, Bioorganic & Medicinal Chemistry, 2004, Bickley, Jamie F et. al.
Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test
score: 0.63599664, Bioorganic & Medicinal Chemistry, 2006, Duarte, Filipe S. et. al.
Redesigning the active-site of an acyl-CoA dehydrogenase: new evidence supporting a one-base mechanism
score: 0.63589059, Bioorganic & Medicinal Chemistry, 1997, Dakoji, Srikanth et. al.
Intramolecular aldol cyclization of l- lyxo-Hexos-5-ulose derivatives: A new diastereoselective synthesis of d- chiro-Inositol
score: 0.63581535, Bioorganic & Medicinal Chemistry Letters, 2002, Catelani, Giorgio et. al.
Effect of Reishi polysaccharides on human stem/progenitor cells
score: 0.63546237, Bioorganic & Medicinal Chemistry, 2010, Chen, Wan-Yu et. al.
Origin of rate-acceleration in ester hydrolysis with metalloprotease mimics
score: 0.63463688, Bioorganic & Medicinal Chemistry, 2000, Kim, Dong H.; Lee, Soo Suk
Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant.
score: 0.63458034, Antimicrobial agents and chemotherapy, 2004, Vargas, Rita C et. al.
Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?
score: 0.63443874, European Journal of Medicinal Chemistry, 2000, McCluskey, Adam et. al.
A strategy of tRNA recognition that includes determinants of RNA structure
score: 0.63439532, Bioorganic & Medicinal Chemistry, 1997, Hamann, Christian S.; Hou, Ya-Ming
Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones “In-Water” and their biological evaluation as antibacterial and antifungal agents
score: 0.63424162, European Journal of Medicinal Chemistry, 2012, Tandon, Vishnu K. et. al.
Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones “In-Water” and their biological evaluation as antibacterial and antifungal agents
score: 0.63424162, European Journal of Medicinal Chemistry, 2012, Tandon, Vishnu K. et. al.
Synthesis and antileishmanial activity of new imidazolidin-2-one derivatives
score: 0.63421908, European Journal of Medicinal Chemistry, 2003, Robert, Jean-Michel H et. al.
Recognition of Nine Base Pair Sequences in the Minor Groove of DNA at Subpicomolar Concentrations by a Novel Microgonotropen
score: 0.63357991, Bioorganic & Medicinal Chemistry, 2002, Satz, Alexander L; Bruice, Thomas C
A New Synthetic Approach to 1-[(3 R,4 R)-1-Cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one (J-113397), the first non-peptide ORL-1 receptor antagonist
score: 0.63346992, Bioorganic & Medicinal Chemistry, 2001, De Risi, Carmela et. al.
Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design
score: 0.63321819, Chemical Biology & Drug Design, 2011, Durrant, Jacob D et. al.
Three more cyclotheonamides, C, D, and E, potent thrombin inhibitors from the marine sponge Theonella swinhoei
score: 0.63282748, Bioorganic & Medicinal Chemistry, 1995, Nakao, Youichi; Matsunaga, Shigeki; Fusetani, Nobuhiro
The role of physiological heterogeneity in microbial population behavior.
score: 0.63213084, Nature chemical biology, 2010, Lidstrom, Mary E; Konopka, Michael C
Crop plants versus energy plants—On the international food crisis
score: 0.63186379, Bioorganic & Medicinal Chemistry, 2009, Schmitz, P.M.; Kavallari, A.
Virtual ligand screening: strategies, perspectives and limitations
score: 0.63167095, Drug Discovery Today, 2006, Klebe, Gerhard
Engineering synthetic recursive pathways to generate non-natural small molecules.
score: 0.63162018, Nature chemical biology, 2012, Felnagle, Elizabeth A et. al.
Self-association of cyclic oligonucleotides through G:T:G:T minor groove tetrads
score: 0.63151233, Bioorganic & Medicinal Chemistry, 2010, Viladoms, Júlia et. al.
N-Butyl-N-methyl-11-(3'-hydroxy-21',17'-carbolactone-19'-nor-17'α-pregna-1',3',5'(10')-trien-7'α-yl)-undecanamide: an inhibitor of type 2 17β-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity
score: 0.63099811, European Journal of Medicinal Chemistry, 2000, Sam, Kay-Mane; Labrie, Fernand; Poirier, Donald
Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties
score: 0.63089396, European Journal of Medicinal Chemistry, 2001, Balsamo, Aldo et. al.
Corrigendum to “Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I–XIV” [Bioorg. Med. Chem. 17 (2009) 5791]
score: 0.63074277, Bioorganic & Medicinal Chemistry, 2010, Coban, T. Abdülkadir et. al.
Synthesis of 2′-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus
score: 0.63064136, Bioorganic & Medicinal Chemistry, 2012, Brzezinska, Jolanta et. al.
Computational study of the electronic structure characterization of a novelanti-inflammatory tripeptide derived from monocyte locomotion inhibitoryfactor (MLIF)-pentapeptide
score: 0.63018827, European Journal of Medicinal Chemistry, 2009, Barrientos-Salcedo, Carolina et. al.
Molecularly imprinted polymer of 5-methyluridine for solid-phase extraction of pyrimidine nucleoside cancer markers in urine
score: 0.6295345, Bioorganic & Medicinal Chemistry, 2008, Jégourel, Damien et. al.
Structure and Ligand Based Drug Design Strategies in the Development of Novel 5-LOX Inhibitors
score: 0.62921123, Current Medicinal Chemistry, 2012, Aparoy, Polamarasetty et. al.
Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries
score: 0.6290229, Chemistry Central Journal, 2012, Han, Bucong et. al.
Recognition and cleavage at the DNA major groove
score: 0.62889867, Bioorganic & Medicinal Chemistry, 2001, Skibo, Edward B.; Xing, Chenggou; Groy, Thomas
N-Terminal amino acid side-chain cleavage of chemically modified peptides in the gas phase: A mass spectrometry technique for N-terminus identification
score: 0.62884876, Bioorganic & Medicinal Chemistry, 2006, Chacon, Almary et. al.
Hypocholesterolemic effects of phenolic-rich extracts of Chemlali olive cultivar in rats fed a cholesterol-rich diet
score: 0.62837054, Bioorganic & Medicinal Chemistry, 2005, Fki, Ines; Bouaziz, Mohamed; Sahnoun, Zouhair; Sayadi, Sami
Natural product-inspired cascade synthesis yields modulators of centrosome integrity.
score: 0.62777495, Nature chemical biology, 2012, Dückert, Heiko et. al.
Systems biology: Metabolites do social networking.
score: 0.62751825, Nature chemical biology, 2011, Kell, Douglas B
Anti-MRSA cephems. Part 2
score: 0.62745062, Bioorganic & Medicinal Chemistry, 2003, Springer, Dane M. et. al.
An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion
score: 0.62669096, European Journal of Medicinal Chemistry, 2009, Khoee, Sepideh; Yaghoobian, Morteza
Metabolomics cuts to the chase to chase the cuts.
score: 0.62665308, Nature chemical biology, 2009, Bogyo, Matthew
Antimicrobial and SOD activities of novel transition metal ternary complexes of iminodiacetic acid containing α-diimine as auxiliary ligand
score: 0.62624992, European Journal of Medicinal Chemistry, 2009, Siddiqi, Zafar A.; Shahid, M.; Khalid, Mohd.; Kumar, S.
Synthesis, β-adrenoceptor pharmacology and toxicology of S-(−)-1-(4-(2-ethoxyethoxy)phenoxy)-2-hydroxy-3-(2-(3,4-dimethoxyphenyl)ethylamino)propane hydrochloride, a short acting β 1-specific antagonist
score: 0.62549518, European Journal of Medicinal Chemistry, 2002, Jackman, Graham P et. al.
Synthesis, Stability and In Vitro Dermal Evaluation of Aminocarbonyloxymethyl Esters as Prodrugs of Carboxylic Acid Agents
score: 0.62503857, Bioorganic & Medicinal Chemistry, 2002, Mendes, Eduarda et. al.
Effects of nucleic acids and polyanions on dimer formation and DNA binding by bZIP and bHLHZip transcription factors
score: 0.62485614, Bioorganic & Medicinal Chemistry, 2001, Kohler, Jennifer J; Schepartz, Alanna
Folded conformation of an immunostimulating tetrapeptide Rigin: high temperature molecular dynamics simulation study
score: 0.62449057, Bioorganic & Medicinal Chemistry, 2002, Ashish, A.; Kishore, R.
Synthesis and biological evaluation of thiophene [3,2- b] pyrrole derivatives as potential anti-inflammatory agents
score: 0.62437331, Bioorganic & Medicinal Chemistry, 2004, Rajender Kumar, P et. al.
Synthesis and characterization of pH-responsive and folated nanoparticles based on self-assembled brush-like PLGA/PEG/AEMA copolymer with targeted cancer therapy properties: A comprehensive kinetic study
score: 0.62427232, European Journal of Medicinal Chemistry, 2012, Khoee, Sepideh; Rahmatolahzadeh, Reza
A convenient synthesis of trans-sabinene hydrate from (−)-3-thujol via a highly selective ene reaction of singlet oxygen
score: 0.62413648, Bioorganic & Medicinal Chemistry, 1996, Baeckström, Peter; Koutek, Bohumir; Šaman, David; Vrkoč, Jan
Plant hormones are versatile chemical regulators of plant growth.
score: 0.62386588, Nature chemical biology, 2009, Santner, Aaron et. al.
Synthesis of new hexahydro- and octahydropyrido[1,2- c]pyrimidine derivatives with an arylpiperazine moiety as ligands for 5-HT 1A and 5-HT 2A receptors. Part 4
score: 0.62367975, European Journal of Medicinal Chemistry, 2006, Herold, Franciszek et. al.
Antibacterial efficacy against an in vivo Salmonella typhimurium infection model and pharmacokinetics of a liposomal ciprofloxacin formulation.
score: 0.62353407, Antimicrobial agents and chemotherapy, 1998, Webb, M S et. al.
Synthesis and structure–activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands
score: 0.62334015, Bioorganic & Medicinal Chemistry, 1998, Leclerc, Véronique et. al.
Chromene-based synthetic chalcones as potent antileishmanial agents: synthesis and biological activity.
score: 0.623238, Chemical biology & drug design, 2010, Foroumadi, Alireza et. al.
CSAR Benchmark Exercise of 2010: Combined Evaluation Across All Submitted Scoring Functions
score: 0.62287829, Journal of Chemical Information and Modeling, 2011, Smith, Richard D. et. al.
Synthesis, crystal structure and larvicidal activity of novel diamide derivatives against Culex pipiens
score: 0.62285084, Chemistry Central Journal, 2012, Wu, Rui et. al.
A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones
score: 0.62268223, Bioorganic & Medicinal Chemistry, 1999, Brady, Kenneth D. et. al.
Diversity oriented one-pot three-component sequential synthesis of annulated benzothiazoloquinazolines
score: 0.62225341, Organic and Medicinal Chemistry Letters, 2012, Kumar, Mahendra; Sharma, Kailash; Sharma, Dinesh Kumar
Biocatalytic combinatorial synthesis
score: 0.62193362, Bioorganic & Medicinal Chemistry, 1999, Krstenansky, John L.; Khmelnitsky, Yuri
Synthesis and DNA nicking studies of a novel cyclic peptide: Cyclo[Lys-Trp-Lys-Ahx-]
score: 0.62168614, Bioorganic & Medicinal Chemistry, 2001, Cheng, Chong-Teh et. al.
Synthesis, NMR spectroscopy study, and antimuscarinic activity of a series of 2-(Acyloxymethyl)-1,3-dioxolanes
score: 0.62143843, Bioorganic & Medicinal Chemistry, 1996, Malmusi, Luca et. al.
Anionic polymer, poly(methyl vinyl ether–maleic anhydride)-coated beads-based capture of human influenza A and B virus
score: 0.62114313, Bioorganic & Medicinal Chemistry, 2009, Sakudo, Akikazu et. al.
How a single inversion of configuration leads to a reversal of the binding mode: proposal of a novel arrangement of CCK 2 ligands in their receptor, and contribution to the development of peptidomimetic or non-peptide CCK 2 ligands
score: 0.62096208, European Journal of Medicinal Chemistry, 2003, Bellier, Bruno; Garbay, Christiane
Pyrrolo[1,2- f]phenanthridines and related non-rigid analogues as antiviral agents
score: 0.62089763, European Journal of Medicinal Chemistry, 2002, Almerico, Anna Maria et. al.
Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex
score: 0.62073528, European Journal of Medicinal Chemistry, 2006, Ludwig, Matthias et. al.
Chemoenzymatic synthesis of l-galactosylated dimeric Sialyl Lewis X structures employing α-1,3-fucosyltransferase V
score: 0.62021069, Bioorganic & Medicinal Chemistry, 2000, Düffels, Arno et. al.
The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase
score: 0.62016266, Bioorganic & Medicinal Chemistry, 2001, Odagaki, Y et. al.
A bacterial selection for the directed evolution of pyruvate aldolases
score: 0.61998872, Bioorganic & Medicinal Chemistry, 2004, Griffiths, Jennifer S et. al.
α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition.
score: 0.61875794, Nature chemical biology, 2011, Doucette, Christopher D et. al.
A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance.
score: 0.6186954, Nature chemical biology, 2011, Zhang, Meng et. al.
Inducible regulation of the S. cerevisiae cell cycle mediated by an RNA aptamer–ligand complex
score: 0.61868409, Bioorganic & Medicinal Chemistry, 2001, Grate, Dilara; Wilson, Charles
Novel Branching Membrane Translocational Peptide as Gene Delivery Vector
score: 0.61807318, Bioorganic & Medicinal Chemistry, 2002, Tung, Ching-Hsuan; Mueller, Stephanie; Weissleder, Ralph
Synthesis and in vitro opioid activity profiles of DALDA analogues
score: 0.61793497, European Journal of Medicinal Chemistry, 2000, Schiller, Peter W et. al.
Synthesis and pharmacological activity of metabolites of the 5-HT 4 receptor antagonist SB-207266
score: 0.61783005, Bioorganic & Medicinal Chemistry, 2001, Fedouloff, Michael et. al.
Conformationally restrained analogues of sympathomimetic catecholamines
score: 0.61778251, European Journal of Medicinal Chemistry, 2002, Balsamo, Aldo et. al.
The role of dicarbonyl compounds in non-enzymatic crosslinking: a structure–activity study
score: 0.61752317, Bioorganic & Medicinal Chemistry, 2003, Meade, Susie J; Miller, Antonia G; Gerrard, Juliet A
Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives
score: 0.61745951, European Journal of Medicinal Chemistry, 2012, Secci, Daniela et. al.
Induction of apoptosis in a leukemia cell line by triterpene saponins from Albizia adianthifolia
score: 0.6172158, Bioorganic & Medicinal Chemistry, 2004, Haddad, Mohamed et. al.
Oxysterols are allosteric activators of the oncoprotein Smoothened.
score: 0.61675709, Nature chemical biology, 2012, Nachtergaele, Sigrid et. al.
The model student: what chemical model systems can teach us about biology.
score: 0.61661832, Nature chemical biology, 2007, Kool, Eric T; Waters, Marcey L
Chemical Probes of UDP-Galactopyranose Mutase
score: 0.61633633, Chemistry & Biology, 2006, Carlson, Erin E.; May, John F.; Kiessling, Laura L.
New phospholipase A 2 inhibitor: Synthesis and inhibition mechanism of oxazolidinone phospholipid analog
score: 0.61550228, Bioorganic & Medicinal Chemistry, 1995, Iwama, Seiji et. al.
Giving Rho(d) directions.
score: 0.61545501, Nature chemical biology, 2010, Muellner, Markus K; Nijman, Sebastian M B
Synthesis, in vitro antifungal evaluation and in silico study of 3-azolyl-4-chromanone phenylhydrazones
score: 0.61507885, DARU Journal of Pharmaceutical Sciences, 2012, Ayati, Adile et. al.
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel
score: 0.61506969, Nature chemical biology, 2011, Liu, Fa et. al.
Cross-linking of proteins by maillard processes: characterization and detection of lysine–arginine cross-links derived from glyoxal and methylglyoxal
score: 0.61421586, Bioorganic & Medicinal Chemistry, 1999, Lederer, Markus O; Klaiber, Ralph G
Specific inhibitors for the glycolytic enzymes of Trypanosoma brucei
score: 0.61372123, Bioorganic & Medicinal Chemistry, 1995, Trinquier, Murielle et. al.
Rational Design of Small Molecule Inhibitors Targeting the Rac GTPase-p67phox Signaling Axis in Inflammation
score: 0.61361186, Chemistry & Biology, 2012, Bosco, Emily E. et. al.
A simple method for the preparation of (5 Z,8 Z,11 Z,14 Z)-16-Hydroxyeicosa-5,8,11,14-tetraenoic acid enantiomers and the corresponding 14,15-Dehydro analogues: role of the 16-Hydroxy group for the lipoxygenase reaction
score: 0.61242685, Bioorganic & Medicinal Chemistry, 2002, Ivanov, Igor V et. al.
Antiproliferative effect of Baylis–Hillman adducts and a new phthalide derivative on human tumor cell lines
score: 0.6124261, European Journal of Medicinal Chemistry, 2006, Kohn, Luciana K. et. al.
Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration
score: 0.61235723, Bioorganic & Medicinal Chemistry Letters, 2001, Ben-Shabat, Shimon et. al.
Effect of arginine mutation of alanine-556 on DNA recognition of zinc finger protein Sp1
score: 0.61140182, Bioorganic & Medicinal Chemistry, 2001, Matsushita, Keizo; Sugiura, Yukio
Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids.
score: 0.61129958, Nature chemical biology, 2007, Long, Xiangtian et. al.
tRNA Phe binds aminoglycoside antibiotics
score: 0.61121177, Bioorganic & Medicinal Chemistry, 1999, Kirk, Sarah R.; Tor, Yitzhak
APEX disease gene resequencing: mutations in exon 7 of the p53 tumor suppressor gene
score: 0.611174, Bioorganic & Medicinal Chemistry, 2001, Shumaker, John M et. al.
Cytotoxic activity of new lanthanum (III) complexes of bis-coumarins
score: 0.61057116, European Journal of Medicinal Chemistry, 2005, Kostova, Irena et. al.
Synthesis and characterisation of polyamine–poly(ethylene glycol) constructs for DNA binding and gene delivery
score: 0.61056152, Bioorganic & Medicinal Chemistry, 2000, Garrett, Shane W et. al.
Disease activated drugs: a new concept for the treatment of asthma
score: 0.61050117, Bioorganic & Medicinal Chemistry, 2001, Charpiot, Brigitte et. al.
Description of hydrophobicity parameters of a mixed set from their three-dimensional structures
score: 0.61023185, Bioorganic & Medicinal Chemistry, 1995, Kim, Ki H.; Kim, Daniel H.
Vomilenine Reductase — a novel Enzyme catalyzing a crucial Step in the Biosynthesis of the Therapeutically applied Antiarrhythmic Alkaloid Ajmaline
score: 0.61014507, Bioorganic & Medicinal Chemistry, 2002, von Schumann, Gerald; Gao, Shujuan; Stöckigt, Joachim
Small-molecule displacement of a cryptic degron causes conditional protein degradation.
score: 0.60968996, Nature chemical biology, 2011, Bonger, Kimberly M et. al.
Synthesis and conformational analysis of pyrimidine nucleoside analogues with a rigid sugar moiety
score: 0.60940871, Bioorganic & Medicinal Chemistry, 1995, Björsne, Magnus et. al.
Estradiol derivatives bearing sulfur-containing substituents at the 11β or 7α positions: versatile reagents for the preparation of estrogen conjugates
score: 0.60920813, Bioorganic & Medicinal Chemistry, 2004, Spera, Daniela et. al.
Synthesis and stereostructure–activity relationship of three asymmetric center pyrethroids: 2-methyl-3-phenylcyclopropyl-methyl 3-phenoxybenzyl ether and cyanohydrin ester
score: 0.60916829, Bioorganic & Medicinal Chemistry, 2001, Nishii, Yoshinori et. al.
Our choices from the recent literature.
score: 0.60909391, Nature chemical biology, 2010,
Zinc-finger hydrolase: Computational selection of a linker and a sequence towards metal activation with a synthetic αββ protein
score: 0.60838674, Bioorganic & Medicinal Chemistry, 2010, Patel, Kirti; Srivastava, Kinshuk Raj; Durani, Susheel
Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa.
score: 0.60831623, Chemical biology & drug design, 2012, Hussein, Waleed M et. al.
A Review of Solid-Phase Organic Synthesis on SynPhase™ Lanterns and SynPhase™ Crowns
score: 0.60822612, Methods in Enzymology, 2003, Parsons, Jack G et. al.
Who cares for the protons?
score: 0.60812884, Bioorganic & Medicinal Chemistry, 2012, Czodrowski, Paul
Who cares for the protons?
score: 0.60812884, Bioorganic & Medicinal Chemistry, 2012, Czodrowski, Paul
Who cares for the protons?
score: 0.60812884, Bioorganic & Medicinal Chemistry, 2012, Czodrowski, Paul
Comparison of positively charged DNG with DNA duplexes: a computational approach
score: 0.60792778, Bioorganic & Medicinal Chemistry, 2005, Toporowski, Joseph W. et. al.
Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives
score: 0.6073482, European Journal of Medicinal Chemistry, 2004, Messaoudi, Samir et. al.
Practical screening of mercury contamination in fish tissue
score: 0.60699281, Bioorganic & Medicinal Chemistry, 2001, Brümmer, Oliver; La Clair, James J; Janda, Kim D
Synthesis and biological evaluation of tetrademethyl isocolchicine derivatives as inhibitors of DNA topoisomerase action in vitro
score: 0.606946, Bioorganic & Medicinal Chemistry, 1993, Bastow, Kenneth F. et. al.
Enhanced ranking of PknB Inhibitors using data fusion methods
score: 0.60684334, Journal of Cheminformatics, 2013, Seal, Abhik et. al.
Synthesis and DNA binding studies of a new asymmetric cyanine dye binding in the minor groove of [poly(dA-dT)] 2
score: 0.6066529, Bioorganic & Medicinal Chemistry, 2003, Karlsson, H.Jonas; Lincoln, Per; Westman, Gunnar
Agonizing hedgehog.
score: 0.60662692, Nature chemical biology, 2006, Briscoe, James
Monoalkylation of DNA by reductively activated FR66979
score: 0.60655359, Bioorganic & Medicinal Chemistry, 2000, Paz, Manuel M.; Sigurdsson, Snorri Th.; Hopkins, Paul B.
Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-β receptor
score: 0.60640142, Bioorganic & Medicinal Chemistry, 1995, Ramalingam, Kalaiyarasi et. al.
SAR by HCS.
score: 0.60614554, Nature chemical biology, 2008, Lang, Paul
Synthesis and antifungal activity of alkylthio and alkylsulfonyl derivatives of SM-8668
score: 0.60566651, Bioorganic & Medicinal Chemistry, 1996, Miyauchi, Hiroshi et. al.
Properties of triple helix formation with oligodeoxyribonucleotides containing 8-oxo-2′-deoxyadenosine and 2′-modified nucleoside derivatives
score: 0.60565042, Bioorganic & Medicinal Chemistry, 1996, Ishibashi, Toshiaki et. al.
Synthesis, conformational analysis and antiviral and antitumoral activity of new 1,2-disubstituted carbocyclic nucleosides
score: 0.6056476, European Journal of Medicinal Chemistry, 2002, Santana, Lourdes et. al.
Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
score: 0.60531966, Nature chemical biology, 2006, Bang, Duhee et. al.
Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.
score: 0.60511623, ChemMedChem, 2008, Brenk, Ruth et. al.
Naphthazarin derivatives (IV): synthesis, inhibition of DNA topoisomerase I and cytotoxicity of 2- or 6-acyl-5,8-dimethoxy-1,4-naphthoquinones
score: 0.60423573, European Journal of Medicinal Chemistry, 2000, Song, Gyu-Yong et. al.
Reaction of 2′-deoxycytidine with peroxynitrite in the presence of ammonium bromide
score: 0.60416742, Bioorganic & Medicinal Chemistry, 2008, Suzuki, Toshinori et. al.
Selective carriers of norepinephrine and ammonium ions: Ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1 H-pyrazol-1-yl)propane unit
score: 0.60404995, Bioorganic & Medicinal Chemistry, 1997, Rodríguez-Franco, María Isabel et. al.
Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction
score: 0.60378266, Bioorganic & Medicinal Chemistry, 2008, Ikuta, Kenjiro et. al.
Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides
score: 0.60337041, Bioorganic & Medicinal Chemistry, 2005, Mori, Megumi et. al.
Synthesis of trifluoromethyl ketones as inhibitors of antennal esterases of insects
score: 0.60313608, Bioorganic & Medicinal Chemistry, 1994, Parrilla, A.; Villuendas, I.; Guerrero, A.
Oxysterols are allosteric activators of the oncoprotein Smoothened
score: 0.6027093, Nature Chemical Biology, 2011, Nachtergaele, Sigrid et. al.
Ring-deactivated hydroxymethylpyrroles as inhibitors of α-chymotrypsin
score: 0.60266133, Bioorganic & Medicinal Chemistry, 2001, Abell, Andrew D.; Nabbs, Brent K.
Solution structure of rifaximin and its synthetic derivative rifaximin OR determined by experimental NMR and theoretical simulation methods
score: 0.60258669, Bioorganic & Medicinal Chemistry, 2004, Martini, Silvia et. al.
A de novo peptide hexamer with a mutable channel.
score: 0.60252067, Nature chemical biology, 2011, Zaccai, Nathan R et. al.
New perfluoroalkylated amphiphilic methacrylates bearing sulfinyl group as monomers for biomedical applications: water content and oxygen permeability of their copolymers with DEGMA
score: 0.60206016, European Journal of Medicinal Chemistry, 2006, Církva, Vladimír et. al.
Cytosine-5-methyltransferases add aldehydes to DNA.
score: 0.60165982, Nature chemical biology, 2009, Liutkeviciute, Zita et. al.
Modular approaches to expanding the functions of living matter.
score: 0.60147405, Nature chemical biology, 2006, Chin, Jason W
1,2,9,9 a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation
score: 0.60134126, Bioorganic & Medicinal Chemistry, 1995, Boger, Dale L.; Yun, Weiya; Han, Nianhe
Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric oxide synthase (iNOS) inhibitors
score: 0.6006447, Journal of Molecular Graphics and Modelling, 2012, Suaifan, Ghadeer A.R.Y. et. al.
Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric oxide synthase (iNOS) inhibitors
score: 0.6006447, Journal of Molecular Graphics and Modelling, 2012, Suaifan, Ghadeer A.R.Y. et. al.
Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric oxide synthase (iNOS) inhibitors
score: 0.6006447, Journal of Molecular Graphics and Modelling, 2012, Suaifan, Ghadeer A.R.Y. et. al.
Synthetic zinc tetrapyrroles complexing with pyridine as a single axial ligand
score: 0.60056138, Bioorganic & Medicinal Chemistry, 1998, Tamiaki, Hitoshi; Yagai, Shiki; Miyatake, Tomohiro
A new class of compounds, peptide derivatives of adenosine 5′-carboxylic acid, includes inhibitors of ATP receptor-mediatedresponses
score: 0.59983876, Bioorganic & Medicinal Chemistry, 1994, Uri, Asko et. al.
Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae.
score: 0.59972879, Nature chemical biology, 2008, Hawkins, Kristy M; Smolke, Christina D
5-Cyanovaleramide production using immobilized pseudomonas chlororaphis B23
score: 0.5991317, Bioorganic & Medicinal Chemistry, 1999, Hann, Eugenia C. et. al.
Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics.
score: 0.59880276, Nature chemical biology, 2006, Price-Whelan, Alexa; Dietrich, Lars E P; Newman, Dianne K
Chemotherapy of leishmaniasis part III: synthesis and bioevaluation of novel aryl substituted terpenyl pyrimidines as antileishmanial agents
score: 0.59839204, European Journal of Medicinal Chemistry, 2006, Chandra, Naveen et. al.
Combinatorial informatics in the post-genomics ERA.
score: 0.59825854, Nature reviews. Drug discovery, 2002, Agrafiotis, Dimitris K et. al.
Synthesis and evaluation of new quinazolone derivatives of nalidixic acid as potential antibacterial and antifungal agents
score: 0.59808417, European Journal of Medicinal Chemistry, 2006, Grover, Gaurav; Kini, Suvarna G.
GlcNAc-Thiazoline conformations
score: 0.59751081, Bioorganic & Medicinal Chemistry, 2009, Knapp, Spencer et. al.
An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
score: 0.59734136, European Journal of Medicinal Chemistry, 2002, Atwell, Graham J; Yang, Shangjin; Denny, William A
Novel screening methods—the key to cloning commercially successful biocatalysts
score: 0.59689002, Bioorganic & Medicinal Chemistry, 1999, Taylor, Stephen J.C et. al.
Protection against Leishmania major infection by oligomannose-coated liposomes
score: 0.59641381, Bioorganic & Medicinal Chemistry, 2003, Shimizu, Yoshitaka et. al.
Naringenin 7- O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats
score: 0.59614531, Bioorganic & Medicinal Chemistry, 2003, Lee, Mi-Kyung et. al.
The exploration of thienothiazines as selective butyrylcholinesterase inhibitors
score: 0.596104, European Journal of Pharmaceutical Sciences, 2012, Karlsson, Daniela et. al.
The exploration of thienothiazines as selective butyrylcholinesterase inhibitors
score: 0.596104, European Journal of Pharmaceutical Sciences, 2012, Karlsson, Daniela et. al.
Diverse backbone-cyclized peptides via codon reprogramming.
score: 0.59582559, Nature chemical biology, 2009, Kawakami, Takashi et. al.
Stereoselectivity in reactions of amino acids catalyzed by pyridoxal derivatives carrying rigidly-Attached chirally-Mounted basic groups—transamination, racemization, decarboxylation, retro-Aldol reaction, and aldol condensation
score: 0.59533765, Bioorganic & Medicinal Chemistry, 2002, Liu, Lei; Rozenman, Mary; Breslow, Ronald
Bacteria and host interactions in the gut epithelial barrier.
score: 0.59508793, Nature chemical biology, 2011, Ashida, Hiroshi et. al.
Antibacterial efficacy of gentamicin encapsulated in pH-sensitive liposomes against an in vivo Salmonella enterica serovar typhimurium intracellular infection model.
score: 0.59506582, Antimicrobial agents and chemotherapy, 2000, Cordeiro, C et. al.
Computational design strategies for combinatorial libraries
score: 0.59504509, Current Opinion in Chemical Biology, 2003, Rose, Sally; Stevens, Adrian
Selection of genomic target RNAs by iterative screening
score: 0.59495347, Bioorganic & Medicinal Chemistry, 2001, Brunel, Christine et. al.
Constitutional isomers of Reactive Blue 2 – selective P2Y-receptor antagonists?
score: 0.59489311, European Journal of Medicinal Chemistry, 2003, Glänzel, Markus et. al.
Studies on the immuno-Modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-Containing glycoprotein fraction responsible for the activities
score: 0.59380191, Bioorganic & Medicinal Chemistry, 2002, Wang, Yuan-Yuan et. al.
Electrochemical studies of S-nitrosothiols
score: 0.59350066, Bioorganic & Medicinal Chemistry Letters, 1998, Hou, Yongchun et. al.
Synthesis and screening of conformationally restricted and conformationally free N-(tertiary aminoalkyl)dithiocarbamic acids and esters as inhibitors of neuronal nitric oxide synthase
score: 0.59338699, Bioorganic & Medicinal Chemistry, 1998, Sassaman, Mark B. et. al.
2- amino-9-(3- azido-2,3- dideoxy-β- d -erythro- pentofuranosyl)-6-substituted-9H- purines : Synthesis and anti-HIV activity
score: 0.59333535, Bioorganic & Medicinal Chemistry, 1995, Freeman, G.A.; Shaver, S.R.; Rideout, J.L.; Short, S.A.
Drug discovery beyond the ‘rule-of-five’
score: 0.59307416, Current Opinion in Biotechnology, 2007, Zhang, Ming-Qiang; Wilkinson, Barrie
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
score: 0.59260068, Nature chemical biology, 2008, Chatterjee, Abhishek et. al.
Novel thieno[2,3- b]- and [3,4- b]pyrans as potassium channel openers. Thiophene systems—XVII
score: 0.59223064, Bioorganic & Medicinal Chemistry, 1993, Press, Jeffery B. et. al.
Behind the folding funnel diagram.
score: 0.59126039, Nature chemical biology, 2011, Karplus, Martin
Discovery of diphenyl amine based sodium channel blockers, effective against hNa v1.2
score: 0.59117869, Bioorganic & Medicinal Chemistry, 2006, Hudgens, Debjani P. et. al.
Vitamins and cofactors: highlights of ESBOC 2009.
score: 0.59079756, Nature chemical biology, 2009, McDonald, Edward
Air to brain, blood to brain and plasma to brain distribution of volatile organic compounds: linear free energy analyses
score: 0.5907144, European Journal of Medicinal Chemistry, 2006, Abraham, Michael H.; Ibrahim, Adam; Acree, William E.
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids
score: 0.590551, Bioorganic & Medicinal Chemistry, 2005, Viegas, Cláudio et. al.
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.
score: 0.59048846, Nature chemical biology, 2006, Austin, Michael B et. al.
Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds
score: 0.59010949, European Journal of Medicinal Chemistry, 2002, Küçükgüzel, Ş.Güniz et. al.
Molecular modelling and conformational analysisof novel glycoprotein (Gp) IIb/IIIa antagonists. Molecular orbital calculationand the condensed heterocyclic derivatives
score: 0.59009671, European Journal of Medicinal Chemistry, 2000, Ono, Shin'ichiro et. al.
Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation
score: 0.58972032, Malaria Journal, 2011, Sullivan, David J; Kaludov, Nikola; Martinov, Martin N
Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes
score: 0.58962333, Bioorganic & Medicinal Chemistry, 1993, Sui, Zhihua et. al.
Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
score: 0.5896232, Nature chemical biology, 2007, Sawa, Tomohiro et. al.
Calorimetric and computational study of enthalpy of formation of 3,6-dibutanoic-1,2,4,5-tetroxane
score: 0.58894873, Bioorganic & Medicinal Chemistry, 2005, Romero, J.M. et. al.
Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.
score: 0.58887409, The Journal of pharmacology and experimental therapeutics, 2010, Henderson, Brandon J et. al.
Discovery of Ligands by a Combination of Computational and NMR-Based Screening: RNA as an Example Target
score: 0.58868937, Methods in Enzymology, 2005, Mayer, Moriz; James, Thomas L.
Discovery of Ligands by a Combination of Computational and NMR-Based Screening: RNA as an Example Target
score: 0.58868937, Methods in Enzymology, 2005, Mayer, Moriz; James, Thomas L.
Synthesis of 2-imidazolidinylidene propanedenitrile derivatives as stimulators of gastrointestinal motility—II
score: 0.58804918, Bioorganic & Medicinal Chemistry, 1994, Sasho, Setsuya et. al.
Networking chemical biology.
score: 0.58734422, Nature chemical biology, 2008,
Probing the specificity of the S 1 binding site of subtilisin Carlsberg with boronic acids
score: 0.58706722, Bioorganic & Medicinal Chemistry, 1994, Seufer-Wasserthal, Peter et. al.
Chemical expansion of cofactor activity.
score: 0.5864262, Nature chemical biology, 2006, Mercer, Andrew C; Burkart, Michael D
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.
score: 0.58635442, Nature chemical biology, 2011, Mata, Miguel A et. al.
Signalomic signatures enlighten drug profiling.
score: 0.5862736, Nature chemical biology, 2006, Abraham, Robert T
Scripps Florida.
score: 0.58619477, Nature chemical biology, 2007, Sheppard, Terry L
INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE
score: 0.58612173, Nature chemical biology, 2011, Grzegorzewicz, Anna E. et. al.
The structure of McN-5652
score: 0.58588404, Bioorganic & Medicinal Chemistry, 2001, Schulze, Oliver et. al.
New 3-benzisothiazolyl and 3-benzisoxazolylpiperazine derivatives with atypical antipsychotic binding profile
score: 0.58509142, European Journal of Medicinal Chemistry, 2002, Orjales, Aurelio et. al.
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
score: 0.58492212, Nature chemical biology, 2012, Serafimova, Iana M et. al.
Antineoplastic activity of benzimidazo[1,2- b]-isoquinolines, indolo[2,3- b]quinolines, and pyridocarbazoles
score: 0.58445298, Bioorganic & Medicinal Chemistry, 1994, Weinkauf, Ronni L. et. al.
Pseudo-cyclic oligonucleotides: in vitro and in vivo properties
score: 0.58408885, Bioorganic & Medicinal Chemistry, 1999, Jiang, Zhiwei et. al.
Principles for designing fluorescent sensors and reporters.
score: 0.58356086, Nature chemical biology, 2011, Lemke, Edward A; Schultz, Carsten
Structure–activity studies leading to (−)1-(Benzofuran-2-yl)-2-propylaminopentane, ((−)BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of Catecholamines and Serotonin in the brain
score: 0.58334196, Bioorganic & Medicinal Chemistry, 2001, Yoneda, Fumio et. al.
Community organizers and (bio)filmmaking.
score: 0.58330057, Nature chemical biology, 2008, Demple, Bruce
Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+
score: 0.58315929, European Journal of Medicinal Chemistry, 2012, Yu, Hui-juan; Chen, Yu; Yu, Lin; Hao, Zhi-feng; Zhou, Li-hua
Synthesis of [ 11C]RPR-72840A and its evaluation as a radioligand for the serotonin reuptake site in positron emission tomography
score: 0.58240388, Bioorganic & Medicinal Chemistry, 1997, Roeda, Dirk et. al.
Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors.
score: 0.58226805, Molecular pharmacology, 2012, Schepetkin, Igor A et. al.
Cancer preventive potential of trichothecenes from Trichothecium roseum
score: 0.58200347, Bioorganic & Medicinal Chemistry, 2003, Konishi, Kazuhide et. al.
Synthesis and structure—activity relationship studies in a series of 2-substituted 1,3-dioxolanes modified at the cationic head
score: 0.58185142, Bioorganic & Medicinal Chemistry, 1997, Angeli, P. et. al.
Synthesis of ionones and carvone analogues: olfactory properties and preliminary toxicity assays
score: 0.58149553, European Journal of Medicinal Chemistry, 2000, Anzaldi, Maria et. al.
Computer-aided design of functional protein interactions.
score: 0.58122337, Nature chemical biology, 2009, Mandell, Daniel J; Kortemme, Tanja
Synthesis and structure–mutagenicity relationship of benzo-annulated cyclopentaphenanthrenes
score: 0.58071226, Bioorganic & Medicinal Chemistry, 2001, Marrocchi, Assunta et. al.
Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21.
score: 0.58017264, Nature chemical biology, 2011, Wang, Yuefeng et. al.
Synthesis and α 1-antagonist activity of derivatives of 4-chloro-5-{4-[2-(2-methoxyphenoxy)-ethyl]-1-piperazinyl}-3(2H)-pyridazinone
score: 0.57994871, European Journal of Medicinal Chemistry, 2000, Strappaghetti, Giovannella et. al.
Imaging nanometer domains of beta-adrenergic receptor complexes on the surface of cardiac myocytes.
score: 0.57985011, Nature chemical biology, 2005, Ianoul, Anatoli et. al.
Chemical informatics and target identification in a zebrafish phenotypic screen.
score: 0.57948314, Nature chemical biology, 2012, Laggner, Christian et. al.
An efficient preparation of polyanionic affinity agent and its evaluation for the measurement of glycated hemoglobin
score: 0.5782525, Bioorganic & Medicinal Chemistry, 2005, Reddy, Rajarathnam E. et. al.
Bioinorganic chemistry: Getting a grip on iron.
score: 0.57785102, Nature chemical biology, 2010, Philpott, Caroline
Chemical chaperones assist intracellular folding to buffer mutational variations.
score: 0.57718284, Nature chemical biology, 2012, Bandyopadhyay, Anannya et. al.
Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata
score: 0.57716273, BMC Microbiology, 2011, Raja, Alsaba F et. al.
Synthesis, cytotoxic activities and proposed mode of binding of a series of bis{[(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl}alkylamines
score: 0.57712498, European Journal of Medicinal Chemistry, 2002, Braña, Miguel F et. al.
Synthesis and biological evaluation of novel 2′-deoxy-4′-thio-imidazole nucleosides
score: 0.57709361, Bioorganic & Medicinal Chemistry, 1999, Wang, Y. et. al.
Discovery of OT4003, a novel, potent, and orally active cys-LT 1 receptor antagonist
score: 0.57708483, Bioorganic & Medicinal Chemistry, 1997, Tværmose-Nielsen, Ole et. al.
DNA-catalyzed sequence-specific hydrolysis of DNA
score: 0.57672406, Nature chemical biology, 2009, Chandra, Madhavaiah; Sachdeva, Amit; Silverman, Scott K.
Visualization of nitric oxide in living cells by a copper-based fluorescent probe.
score: 0.57647226, Nature chemical biology, 2006, Lim, Mi Hee; Xu, Dong; Lippard, Stephen J
New quinoxalinecarbonitrile 1,4-di-N-oxide derivatives as hypoxic-cytotoxic agents
score: 0.57547189, European Journal of Medicinal Chemistry, 2000, Ortega, Miguel Ángel et. al.
Aggregator compounds confound amyloid fibrillization assay.
score: 0.57540471, Nature chemical biology, 2008, Rishton, Gilbert M
Anti-HIV-1 activity of an antisense phosphorothioate oligonucleotide bearing imidazole and primary amine groups
score: 0.57534015, Bioorganic & Medicinal Chemistry, 2001, Ushijima, Kaoru et. al.
Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels.
score: 0.57507099, Nature chemical biology, 2006, Giraldes, John W et. al.
Opportunities and challenges in plant chemical biology.
score: 0.57504307, Nature chemical biology, 2009, Hicks, Glenn R; Raikhel, Natasha V
Synthesis and Properties of Triple Helix-Forming Oligodeoxyribonucleotides containing 7-Chloro-7-deaza-2′-deoxyguanosine
score: 0.57493427, Bioorganic & Medicinal Chemistry, 2001, Aubert, Yves et. al.
Sulfonates-PMMA nanoparticles conjugates: A versatile system for multimodal application
score: 0.57387849, Bioorganic & Medicinal Chemistry, 2012, Monasterolo, Claudio et. al.
Networking by small-molecule hormones in plant immunity.
score: 0.5736618, Nature chemical biology, 2009, Pieterse, Corné M J et. al.
Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes.
score: 0.57323518, Nature chemical biology, 2012, Netz, Daili J A et. al.
Structure-Based Discovery of a Novel, Noncovalent Inhibitor of AmpC β-Lactamase
score: 0.57317453, Structure, 2002, Powers, Rachel A.; Morandi, Federica; Shoichet, Brian K.
NO place to hide.
score: 0.57270028, Nature chemical biology, 2006, Finney, Nathaniel
Synthetic ceramide analogues as skin permeation enhancers: structure–Activity relationships
score: 0.57252452, Bioorganic & Medicinal Chemistry, 2003, Vávrová, Kateřina et. al.
PEG–Ara-C conjugates for controlled release
score: 0.57243057, European Journal of Medicinal Chemistry, 2004, Schiavon, O et. al.
Biosynthesis: An HR-PKS stereo surprise.
score: 0.5722819, Nature chemical biology, 2012, Abe, Ikuro
Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα
score: 0.572176, Bioorganic & Medicinal Chemistry, 2012, Klausmeyer, Paul et. al.
Frontiers in drug discovery.
score: 0.57166844, Nature chemical biology, 2006,
Disease-Specific Non-Reducing End Carbohydrate Biomarkers for Mucopolysaccharidoses
score: 0.57118374, Nature Chemical Biology, 2011, Lawrence, Roger et. al.
Making carbon-nitrogen bonds in biological and chemical synthesis.
score: 0.57110871, Nature chemical biology, 2006, Hili, Ryan; Yudin, Andrei K
Biomimetic oxidation of ibuprofen with hydrogen peroxide catalysed by horseradish peroxidase (HRP) and 5,10,15,20- tetrakis-(2′,6′-dichloro-3′-sulphonatophenyl)porphyrinatoiron(III) and manganese(III) hydrates in AOT reverse micelles
score: 0.57054133, Bioorganic & Medicinal Chemistry, 1999, Chauhan, S.M.S.; Sahoo, B.B.
Phosphodiesterase 4 inhibitors, structurally unrelated to Rolipram, as promising agents for the treatment of asthma and other pathologies
score: 0.57053262, European Journal of Medicinal Chemistry, 2000, Dal Piaz, Vittorio; Giovannoni, Maria Paola
Protein localization: Can too much lipid glue stop Ras?
score: 0.57033579, Nature chemical biology, 2010, Cox, Adrienne D
A chemical genetic screen reveals a resistance mechanism to PI3K inhibitors in cancer
score: 0.57001996, Nature Chemical Biology, 2011, Muellner, Markus K et. al.
Reaction medium engineering in enzymatic peptide fragment condensation: synthesis of Eledoisin and LH-RH
score: 0.56830155, Bioorganic & Medicinal Chemistry, 1998, Björup, Peter et. al.
Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase
score: 0.56797502, Bioorganic & Medicinal Chemistry, 2002, Griffiths, Jennifer S et. al.
Traceless native protein labeling in mice.
score: 0.56764619, Nature chemical biology, 2009, Lin, Qing; Lim, Reyna K V
Self-reporting peptides illuminate the MHC groove.
score: 0.56755921, Nature chemical biology, 2007, Yewdell, Jonathan W; Lev, Avital
Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria.
score: 0.56724125, Nature chemical biology, 2010, Carnes, Eric C et. al.
Cytotoxic activity of new neodymium (III) complexes of bis-coumarins
score: 0.56722255, European Journal of Medicinal Chemistry, 2004, Kostova, Irena; Manolov, Ilia; Momekov, Georgi
Glycoprotein-inspired materials promote the proteolytic release of cell surface l-Selectin
score: 0.56668436, Bioorganic & Medicinal Chemistry, 1998, Gordon, Eva J.; Strong, Laura E.; Kiessling, Laura L.
Recognition of RNA by triplex formation: Divergent effects of pyrimidine C-5 methylation
score: 0.56628778, Bioorganic & Medicinal Chemistry, 1997, Wang, Shaohui; Xu, Yanzheng; Kool, Eric T.
Synthesis, molecular modelling, and antiproliferative and cytotoxic effects of carbocyclic derivatives of distamycin with chlorambucil moiety
score: 0.56614723, European Journal of Medicinal Chemistry, 2001, Bartulewicz, Danuta et. al.
Identification of novel inhibitors of dipeptidylcarboxypeptidase of Leishmania donovani via ligand-based virtual screening and biological evaluation.
score: 0.56579912, Chemical biology & drug design, 2012, Gangwar, Sonali et. al.
Key involvement of all three GlcNAc hydroxyl groups in the recognition of β-D-Glc pNAc-(1→2)-α-D-Man p-(1→6)-β-D-Glc p-OR by N-acetylglucosaminyltransferase-V
score: 0.56547659, Bioorganic & Medicinal Chemistry, 1994, Kanie, Osamu et. al.
Combining hydrophobicity and helicity: a novel approach to membrane protein structure prediction
score: 0.56521975, Bioorganic & Medicinal Chemistry, 1999, Liu, Li-Ping; Deber, Charles M.
Radiofluorinated histamine H3 receptor antagonist as a potential probe for in vivo PET imaging: Radiosynthesis and pharmacological evaluation
score: 0.5650164, Bioorganic & Medicinal Chemistry, 2012, Selivanova, Svetlana V. et. al.
Radiofluorinated histamine H3 receptor antagonist as a potential probe for in vivo PET imaging: Radiosynthesis and pharmacological evaluation
score: 0.5650164, Bioorganic & Medicinal Chemistry, 2012, Selivanova, Svetlana V. et. al.
Synthesis, antiviral activity, and bioavailability studies of γ-lactam derived HIV protease inhibitors
score: 0.56474693, Bioorganic & Medicinal Chemistry, 1994, Hungate, Randall W. et. al.
The binding of guanine–guanine mismatched DNA to naphthyridine dimer immobilized sensor surfaces: kinetic aspects
score: 0.56463956, Bioorganic & Medicinal Chemistry, 2004, Nakatani, Kazuhiko et. al.
Analysis of the non-covalent interaction between metal ions and the cysteine-Rich domain of protein kinase C eta by electrospray ionization mass spectrometry
score: 0.56426652, Bioorganic & Medicinal Chemistry, 2003, Shindo, Mayumi et. al.
Polymer-Supported catalysts: Enantioselective hydrogenation and hydrogen transfer reduction
score: 0.56424797, Bioorganic & Medicinal Chemistry Letters, 2002, Saluzzo, Christine et. al.
Synthesis and immunofluorescence assay of a new biotinylated paclitaxel
score: 0.56398075, European Journal of Medicinal Chemistry, 2002, Sambaiah, Thota et. al.
Pursuing the leadlikeness concept in pharmaceutical research
score: 0.56364184, Current Opinion in Chemical Biology, 2004, Hann, Mike M; Oprea, Tudor I
Structural basis of p38α regulation by hematopoietic tyrosine phosphatase.
score: 0.56359126, Nature chemical biology, 2011, Francis, Dana M et. al.
Protease inhibitors – Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase
score: 0.56344598, European Journal of Medicinal Chemistry, 2000, Scozzafava, Andrea; Supuran, Claudiu T
Attempts to obtain more efficient GAC-cleaving hammerhead ribozymes by in vitro selection
score: 0.56304473, Bioorganic & Medicinal Chemistry, 2000, Kore, Anilkumar R; Carola, Christophe; Eckstein, Fritz
Water-soluble polymer–drug conjugates for combination chemotherapy against visceral leishmaniasis
score: 0.56237686, Bioorganic & Medicinal Chemistry, 2010, Nicoletti, Salvatore; Seifert, Karin; Gilbert, Ian H.
Dialkylaminoalkylindolonaphthyridines as potential antitumour agents: synthesis, cytotoxicity and DNA binding properties
score: 0.56180479, European Journal of Medicinal Chemistry, 2002, Dalla Via, Lisa et. al.
Fluorescent and biotinylated analogues of docetaxel: Synthesis and biological evaluation
score: 0.56177638, Bioorganic & Medicinal Chemistry, 1995, Dubois, Joëlle et. al.
Assaying phenothiazine derivatives as trypanothione reductase and glutathione reductase inhibitors by theoretical docking and Molecular Dynamics studies
score: 0.56173159, Journal of Molecular Graphics and Modelling, 2009, Iribarne, F.; Paulino, M.; Aguilera, S.; Tapia, O.
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
score: 0.56158771, Chemmedchem, 2011, Spinks, Daniel et. al.
Structural aspects of flavonoids as trypsin inhibitors
score: 0.56153394, European Journal of Medicinal Chemistry, 2004, Maliar, Tibor et. al.
Systematic synthesis of N-methyl-1-deoxynojirimycin-containing, Le x, Le a, sialyl-Le x and sialyl-Le a epitopes recognized by selectins
score: 0.56123421, Bioorganic & Medicinal Chemistry, 1994, Kiso, Makoto et. al.
Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions
score: 0.56120918, Bioorganic & Medicinal Chemistry, 2003, Wada, Masaru et. al.
Virtual screening of GPCRs: An in silico chemogenomics approach
score: 0.56041123, BMC Bioinformatics, 2008, Jacob, Laurent et. al.
13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase.
score: 0.56018603, Nature chemical biology, 2008, Hanes, Jeremiah W; Keresztes, Ivan; Begley, Tadhg P
COX-1/COX-2 inhibitors based on the methanone moiety
score: 0.56000761, European Journal of Medicinal Chemistry, 2002, Dannhardt, Gerd; Fiebich, Bernd L; Schweppenhäuser, Johannes
One-way traffic control in replication termination.
score: 0.55943692, Nature chemical biology, 2006, Theis, Karsten
Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators
score: 0.55930214, Bioorganic & Medicinal Chemistry, 2012, Takács, Daniella et. al.
CD15 expression in human myeloid cell differentiation is regulated by sialidase activity.
score: 0.55916485, Nature chemical biology, 2008, Gadhoum, Samah Zeineb; Sackstein, Robert
Improved synthesis of the bifunctional chelating agent 1,4,7,10-tetraaza- N-(1-carboxy-3-(4-nitrophenyl)propyl)- N′, N″, N‴- tris(acetic acid)cyclododecane (PA-DOTA)
score: 0.5590759, Bioorganic & Medicinal Chemistry, 1999, Chappell, Lara L. et. al.
Scaffold proteins as dynamic switches.
score: 0.55889109, Nature chemical biology, 2007, Zhang, Mingjie
Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines
score: 0.55851018, Bioorganic & Medicinal Chemistry, 2012, Hashimoto, Chie et. al.
Oxidative conjugation of chlorogenic acid with glutathione
score: 0.55801958, Bioorganic & Medicinal Chemistry, 2003, Panzella, Lucia; Napolitano, Alessandra; d'Ischia, Marco
4′-α- C-Branched N, O-nucleosides: synthesis and biological properties
score: 0.55732291, Bioorganic & Medicinal Chemistry, 2004, Chiacchio, Ugo et. al.
β-Hairpin and β-sheet formation in designed linear peptides
score: 0.55670002, Bioorganic & Medicinal Chemistry, 1999, Ramı́rez-Alvarado, Marina et. al.
Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists
score: 0.55559666, European Journal of Pharmaceutical Sciences, 2013, Yrjölä, Sari et. al.
Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking.
score: 0.55558232, Nature chemical biology, 2005, Han, Shoufa et. al.
4-Aminopyridine derivatives with antiamnesic activity # # Presented in part at the Italian–Hungarian–Polish Joint Meeting on Medicinal Chemistry, Giardini Naxos–Taormina, September 28th–October 1st 1999.
score: 0.55511711, European Journal of Medicinal Chemistry, 2000, Andreani, Aldo et. al.
Synthesis, characterization, and in vivo skeletal localization of a new 99mTc-based multidentate phosphonate chelate: 5-Amino-1,3-bis(ethylamine-( N, N dimethyl diphosphonic acid) acetamido) benzene
score: 0.55470695, Bioorganic & Medicinal Chemistry, 2007, Panwar, Puja et. al.
Synthesis and structure–activity relationships of new arylpiperazines: para substitution with electron-withdrawing groups decrease binding to 5-HT 1A and D 2A receptors
score: 0.55430265, European Journal of Medicinal Chemistry, 2002, Santana, Lourdes et. al.
A concerted mechanism for berberine bridge enzyme.
score: 0.55425796, Nature chemical biology, 2008, Winkler, Andreas et. al.
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
score: 0.55407726, Nature chemical biology, 2011, Gupta, Rinkoo D et. al.
Alternative heterocycles for DNA recognition
score: 0.55404713, Bioorganic & Medicinal Chemistry, 2001, Nguyen, Doan H. et. al.
Grand challenge commentary: RNA epigenetics?
score: 0.55381174, Nature chemical biology, 2010, He, Chuan
Anti-tumor-promoting activity of simple models of galactoglycerolipids with branched and unsaturated acyl chains
score: 0.55379692, European Journal of Medicinal Chemistry, 2005, Colombo, Diego et. al.
Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy.
score: 0.55364648, Nature chemical biology, 2011, Pezacki, John Paul et. al.
The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia ( Hansenula) holstii NRRL Y-2448
score: 0.55352362, Bioorganic & Medicinal Chemistry, 2004, Fairweather, Jon K.; Karoli, Tomislav; Ferro, Vito
Small molecule versus DNA repair nanomachine.
score: 0.55285468, Nature chemical biology, 2008, Stivers, James T
Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis
score: 0.55238087, Chemmedchem, 2009, Richardson, John L et. al.
Characterization of chlorophyll pigments in the mutant lacking 8-vinyl reductase of green photosynthetic bacterium Chlorobaculum tepidum
score: 0.55237009, Bioorganic & Medicinal Chemistry, 2012, Mizoguchi, Tadashi; Harada, Jiro; Tamiaki, Hitoshi
Beyond blueprints.
score: 0.5523416, Nature chemical biology, 2012,
The role of the conserved histidine-aspartate pair in the ‘base-off’ binding of cobalamins
score: 0.55187538, Bioorganic & Medicinal Chemistry, 2004, Chen, Hao-Ping et. al.
Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole
score: 0.55169271, Bioorganic & Medicinal Chemistry, 2000, Bremer, Ryan E et. al.
Improvement of ligand economy controlled by polymer morphology: The case of polymer-Supported bis(oxazoline) catalysts
score: 0.55161371, Bioorganic & Medicinal Chemistry Letters, 2002, Burguete, M.I. et. al.
Enediyne-mediated cleavage of RNA
score: 0.55130356, Bioorganic & Medicinal Chemistry, 1995, Battigello, Jean-Marc A. et. al.
Introducing genetically encoded aldehydes into proteins.
score: 0.551144, Nature chemical biology, 2007, Carrico, Isaac S; Carlson, Brian L; Bertozzi, Carolyn R
Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants
score: 0.5508419, European Journal of Medicinal Chemistry, 2003, Guillonneau, Claude et. al.
New amino-nitroxide spin labels
score: 0.5507716, Bioorganic & Medicinal Chemistry, 1996, Dragutan, Ileana et. al.
Screening: Your brain on drugs.
score: 0.55073465, Nature chemical biology, 2010, Saxe, Jonathan P
Cross-dressing proteins by olefin metathesis.
score: 0.55062691, Nature chemical biology, 2008, Kirshenbaum, Kent; Arora, Paramjit S
The origins of chemical biology.
score: 0.55052452, Nature chemical biology, 2006, Morrison, Kim L; Weiss, Gregory A
Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata
score: 0.55014698, Bioorganic & Medicinal Chemistry, 1998, Haraguchi, Hiroyuki et. al.
Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor
score: 0.5495718, European Journal of Medicinal Chemistry, 2005, Hjerde, Erik; Dahl, Svein G.; Sylte, Ingebrigt
Global mapping of pharmacological space.
score: 0.54936253, Nature biotechnology, 2006, Paolini, Gaia V et. al.
Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening
score: 0.54893773, ACS Chemical Neuroscience, 2010, Mueller, Ralf et. al.
Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities
score: 0.54874603, European Journal of Medicinal Chemistry, 2001, Karakurt, Arzu et. al.
Proteins that smell: Pheromone recognition and signal transduction
score: 0.54849953, Bioorganic & Medicinal Chemistry, 1996, Prestwich, Glenn D.
A road map of cellular protein homeostasis.
score: 0.54837514, Nature chemical biology, 2009, Ang, Xiaolu L; Harper, J Wade
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
score: 0.54820757, Nature chemical biology, 2009, Gondry, Muriel et. al.
Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates.
score: 0.54738732, Nature chemical biology, 2010, Lee, Jiyong et. al.
Metabolism: biofuel via biodetoxification.
score: 0.54729154, Nature chemical biology, 2010, Dong, Hongwei; Bao, Jie
The function of terpene natural products in the natural world.
score: 0.54657452, Nature chemical biology, 2007, Gershenzon, Jonathan; Dudareva, Natalia
A place for thioether chemistry in cellular copper ion recognition and trafficking.
score: 0.5461659, Nature chemical biology, 2008, Davis, Anna V; O'Halloran, Thomas V
Killing 84 birds with one stone.
score: 0.54589835, Nature chemical biology, 2009, Waldmann, Herbert
Calculation and application of activity discriminants in lead optimization
score: 0.54583395, Journal of Molecular Graphics and Modelling, 2010, Luo, Xincai et. al.
Decoding chemical structures from genomes.
score: 0.54546223, Nature chemical biology, 2005, Bachmann, Brian O
All natural.
score: 0.54514144, Nature chemical biology, 2007,
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
score: 0.54450962, Nature chemical biology, 2012, Sullivan, Kelly D et. al.
Design, synthesis and biological evaluation of novel betulinic acid derivatives
score: 0.54439066, Chemistry Central Journal, 2012, Yang, Shengjie et. al.
New γ-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity
score: 0.54431417, European Journal of Medicinal Chemistry, 2000, Kokuryo, Yoshitsugu et. al.
A de novo peptide hexamer with a mutable channel
score: 0.54429892, Nature Chemical Biology, 2011, Zaccai, Nathan R. et. al.
Structure-Based De Novo Design of Eya2 Phosphatase Inhibitors
score: 0.54399646, Journal of Molecular Graphics and Modelling, 2012, Park, Hwangseo; Ryu, Seong Eon; Kim, Seung Jun
Constrained glycopeptide ligands for MPRs. Limitations of unprotected phosphorylated building blocks
score: 0.54329612, Bioorganic & Medicinal Chemistry, 1997, Franzyk, Henrik et. al.
Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes
score: 0.54308794, European Journal of Medicinal Chemistry, 2005, Perez-Rebolledo, Anayive et. al.
Synthesis of a [6- Pyridinyl- 18F]-labelled fluoro derivative of WAY-100635 as a candidate radioligand for brain 5-HT 1A receptor imaging with PET
score: 0.5428794, Bioorganic & Medicinal Chemistry, 2003, Karramkam, Mylène et. al.
Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine.
score: 0.54287808, Nature chemical biology, 2005, Mitchell, Douglas A; Marletta, Michael A
Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells.
score: 0.54242434, Nature chemical biology, 2010, Subramanian, Devaraj et. al.
Pharmacophore-based discovery of ligands for drug transporters
score: 0.54232104, Advanced Drug Delivery Reviews, 2006, Chang, Cheng et. al.
A systematic approach to protein glycosylation analysis: a path through the maze.
score: 0.5416621, Nature chemical biology, 2010, Mariño, Karina et. al.
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-( p-nitrobenzyl)- trans-CyDTPA
score: 0.54165262, Bioorganic & Medicinal Chemistry, 1997, Wu, C. et. al.
Synthesis and characterization of modified nucleotides in the 970 hairpin loop of Escherichia coli 16S ribosomal RNA
score: 0.54139447, Bioorganic & Medicinal Chemistry, 2009, Abeydeera, N. Dinuka; Chow, Christine S.
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.
score: 0.54115758, Nature chemical biology, 2007, Bergmann, Sebastian et. al.
Bcl-2 turns deadly.
score: 0.54103287, Nature chemical biology, 2008, Qi, Bing; Hardwick, J Marie
A new family of ATP-dependent oligomerization-macrocyclization biocatalysts.
score: 0.54040843, Nature chemical biology, 2007, Kadi, Nadia et. al.
LC/MS analysis of cellular RNA reveals NAD-linked RNA.
score: 0.54012482, Nature chemical biology, 2009, Chen, Y Grace et. al.
A simple procedure for solid-phase synthesis of peptide nucleic acids with N-terminal cysteine
score: 0.53960036, Bioorganic & Medicinal Chemistry Letters, 1998, Goodwin, Thomas E. et. al.
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.
score: 0.53957719, Nature chemical biology, 2007, Blum, Galia et. al.
Arbutin synthase, a novel member of the NRD1β glycosyltransferase family, is a unique multifunctional enzyme converting various natural products and xenobiotics
score: 0.53909154, Bioorganic & Medicinal Chemistry, 2002, Hefner, Tobias et. al.
Assessment of chemical libraries for their druggability
score: 0.53906907, Computational Biology and Chemistry, 2005, Sirois, Suzanne et. al.
Detection of small organic analytes by fluorescing molecular switches
score: 0.53905193, Bioorganic & Medicinal Chemistry, 2001, Frauendorf, Christian; Jäschke, Andres
Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach.
score: 0.53893551, The pharmacogenomics journal, 2008, Rahnasto, M et. al.
Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
score: 0.53859092, Chemistry & Biology, 2012, Van Molle, Inge et. al.
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit.
score: 0.53846276, Nature chemical biology, 2011, Ni, Qiang et. al.
Signaling Diversity of PKA Achieved Via a Ca 2+ -cAMP-PKA Oscillatory Circuit
score: 0.53846276, Nature chemical biology, 2010, Ni, Qiang et. al.
trans-Fatty acids and radical stress: What are the real culprits?
score: 0.53798864, Bioorganic & Medicinal Chemistry, 2006, Chatgilialoglu, Chryssostomos et. al.
Jeremy Knowles.
score: 0.53778891, Nature chemical biology, 2006, Kotz, Joanne
In vivo selection of tumor-targeting RNA motifs.
score: 0.53722293, Nature chemical biology, 2010, Mi, Jing et. al.
Cyclization of natural products.
score: 0.53703524, Nature chemical biology, 2006, O'Connor, Sarah E
Synthesis and vasodilator effects of 3- and 7-sulfonylurea-1,2,4-benzothiadiazin-1,1-dioxides on rat aorta
score: 0.53683171, Bioorganic & Medicinal Chemistry, 1995, Khelili, Smail et. al.
Exploring NMR ensembles of calcium binding proteins: Perspectives to design inhibitors of protein-protein interactions
score: 0.53680533, BMC Structural Biology, 2011, Isvoran, Adriana et. al.
Isocyanides in the synthesis of nitrogen heterocycles.
score: 0.53654418, Angewandte Chemie (International ed. in English), 2010, Lygin, Alexander V; de Meijere, Armin
7-Hydroxy-2-substituted-4- H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study
score: 0.53607791, European Journal of Medicinal Chemistry, 2001, Costantino, Luca et. al.
Small molecules can have big effects on endurance.
score: 0.53595494, Nature chemical biology, 2008, Baar, Keith; Hardie, D Grahame
Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity
score: 0.53590727, European Journal of Medicinal Chemistry, 2001, Domı́nguez, José N et. al.
One pathway, many products.
score: 0.53496053, Nature chemical biology, 2007, Fischbach, Michael A; Clardy, Jon
Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators
score: 0.53472892, Bioorganic & Medicinal Chemistry, 2012, Takács, Daniella et. al.
Cyclic peptide models of the Ca 2+-binding loop of α-lactalbumin
score: 0.5334411, Bioorganic & Medicinal Chemistry, 2005, Farkas, Viktor et. al.
Protein cross-linking mediated by metalloporphyrins
score: 0.53294374, Bioorganic & Medicinal Chemistry, 1998, Campbell, Lara A.; Kodadek, Thomas; Brown, Kathlynn C.
Trypanocidal activity of dicationic compounds related to pentamidine
score: 0.53284608, European Journal of Medicinal Chemistry, 2001, Donkor, Isaac O et. al.
Back to the future of nucleic acid self-amplification.
score: 0.53197784, Nature chemical biology, 2009, Ellington, Andrew D
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.
score: 0.53196916, Nature chemical biology, 2011, Patton, Gregory C et. al.
Stopping replication, at the beginning.
score: 0.53144933, Nature chemical biology, 2008, Jackson, Peter K
Channels: A TR(i)P in the air.
score: 0.53129453, Nature chemical biology, 2011, Zygmunt, Peter M
Reprogramming Bacteria to Seek and Destroy a Herbicide
score: 0.5309759, Nature chemical biology, 2010, Sinha, Joy; Reyes, Samuel J.; Gallivan, Justin P.
Design of a gene family screening library targeting G-protein coupled receptors
score: 0.53074767, Journal of Molecular Graphics and Modelling, 2004, Lamb, Michelle L. et. al.
Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding
score: 0.53053181, European Journal of Medicinal Chemistry, 2001, Kieć-Kononowicz, Katarzyna et. al.
Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin.
score: 0.53032849, Nature chemical biology, 2012, Patti, Gary J et. al.
Glycan chain-length control.
score: 0.53024997, Nature chemical biology, 2010, Whitfield, Chris
7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-COa reductase inhibitors
score: 0.53011237, Bioorganic & Medicinal Chemistry, 1994, Cecchetti, Violetta et. al.
Carbonic anhydrase inhibitors. Part 86. A QSAR studyon some sulfonamide drugs which lower intra-ocular pressure,using the ACE non-linear statistical method
score: 0.52908898, European Journal of Medicinal Chemistry, 2000, Clare, Brian W.; Supuran, Claudiu T.
Paclitaxel–HSA interaction. Binding sites on HSA molecule
score: 0.52900856, Bioorganic & Medicinal Chemistry, 2004, Trynda-Lemiesz, Lilianna
Synthesis and screening of novel vitamin E derivatives for anticancer functions
score: 0.52871307, European Journal of Medicinal Chemistry, 2012, Chen, Wenbin et. al.
Synthesis and screening of novel vitamin E derivatives for anticancer functions
score: 0.52871307, European Journal of Medicinal Chemistry, 2012, Chen, Wenbin et. al.
Antioxidant Potential of Natural and Synthesised Polyprenylated Hydroquinones
score: 0.5284253, Bioorganic & Medicinal Chemistry, 2002, Tziveleka, Leto-A et. al.
Small-molecule dissection of BMP signaling.
score: 0.52831485, Nature chemical biology, 2008, Anderson, Gregory J; Darshan, Deepak
Structure-based de novo design of Eya2 phosphatase inhibitors
score: 0.52822161, Journal of Molecular Graphics and Modelling, 2012, Park, Hwangseo; Ryu, Seong Eon; Kim, Seung Jun
Structure-based de novo design of Eya2 phosphatase inhibitors
score: 0.52822161, Journal of Molecular Graphics and Modelling, 2012, Park, Hwangseo; Ryu, Seong Eon; Kim, Seung Jun
Structure-based de novo design of Eya2 phosphatase inhibitors
score: 0.52822161, Journal of Molecular Graphics and Modelling, 2012, Park, Hwangseo; Ryu, Seong Eon; Kim, Seung Jun
Anti-HIV and Cytotoxic Activities of Ru(II)/Ru(III) Polypyridyl Complexes Containing 2,6-(2′-Benzimidazolyl)-pyridine/chalcone as Co-Ligand
score: 0.52817464, Bioorganic & Medicinal Chemistry, 2001, Mishra, Lallan et. al.
Identification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach
score: 0.52811429, Bioorganic & Medicinal Chemistry, 1995, Samson, Isabelle et. al.
Chemistry comes to the cell: ASCB 2005.
score: 0.52806941, Nature chemical biology, 2006, Marshall, Thomas W; Cai, Liang; Bear, James E
A Golgi-on-a-chip for glycan synthesis.
score: 0.5278812, Nature chemical biology, 2009, Xu, Ding; Esko, Jeffrey D
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
score: 0.52717404, Nature chemical biology, 2011, Moulick, Kamalika et. al.
Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function.
score: 0.52709678, Molecular pharmacology, 2009, Jiang, Hao et. al.
Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
score: 0.52617809, The Open Medicinal Chemistry Journal, 2009, Chu, Guo-Hua et. al.
Intermolecular interaction and morphology investigation of drug loaded ABA-triblock copolymers with different hydrophilic/lipophilic ratios
score: 0.52606864, Bioorganic & Medicinal Chemistry, 2010, Khoee, Sepideh; Rahimi, Hasan B.
Grand challenge commentary: Synthetic immunology to engineer human immunity.
score: 0.52585687, Nature chemical biology, 2010, Spiegel, David A
Nitrite as an intrinsic signaling molecule.
score: 0.52530309, Nature chemical biology, 2005, Gladwin, Mark T
Carbonic anhydrase inhibitors - Part 94. 1,3,4-Thiadiazole-2-sulfonamide derivatives as antitumor agents? # 1 # See reference [1]
score: 0.52523959, European Journal of Medicinal Chemistry, 2000, Supuran, Claudiu T.; Scozzafava, Andrea
Preparation of a subcellular conjugate with the lipopolysaccharide from Vibrio cholerae 01 using β- d-glucan as matrix
score: 0.52505878, European Journal of Medicinal Chemistry, 2002, Machová, Eva et. al.
Finding the sweet spot: the role of nature and nurture in medicinal chemistry.
score: 0.5247336, Nature reviews. Drug discovery, 2012, Hann, Michael M; Keserü, György M
A spectroscopy approach for the study of the interactions of bioactive vanadium species with bovine serum albumin
score: 0.52456556, Bioorganic & Medicinal Chemistry, 2008, Ferrer, Evelina G. et. al.
Conformationally restricted analogues of the potent CCK-B antagonist CI-988
score: 0.52431026, Bioorganic & Medicinal Chemistry, 1993, Higginbottom, M. et. al.
Robust immune responses elicited by a fully synthetic three-component vaccine.
score: 0.52391302, Nature chemical biology, 2007, Ingale, Sampat et. al.
Synthetic biology: Automated design of RNA devices.
score: 0.52382023, Nature chemical biology, 2012, Isaacs, Farren J
ortho-Carboranyl Glycosides for the Treatment of Cancer by Boron Neutron Capture Therapy
score: 0.52359086, Bioorganic & Medicinal Chemistry, 2001, Tietze, Lutz F et. al.
New ligands at the melatonin binding site MT 3
score: 0.52193906, European Journal of Medicinal Chemistry, 2006, Boussard, Marie-Françoise et. al.
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
score: 0.52192422, Nature chemical biology, 2009, Horie, Akira et. al.
Design, synthesis and biological activity of new neurohypophyseal hormones analogues conformationally restricted in the N -terminal part of the molecule. Highly potent OT receptor antagonists
score: 0.5208027, Amino Acids, 2011, Kwiatkowska, Anna et. al.
Synthesis of natural product inspired compound collections.
score: 0.51977813, Angewandte Chemie (International ed. in English), 2009, Kumar, Kamal; Waldmann, Herbert
The role of conformational entropy in molecular recognition by calmodulin.
score: 0.51970757, Nature chemical biology, 2010, Marlow, Michael S et. al.
CH/π interactions in the crystal structure of TATA-box binding protein/DNA complexes
score: 0.51956803, Bioorganic & Medicinal Chemistry, 2000, Umezawa, Yoji; Nishio, Motohiro
Chemical chaperones assist intracellular folding to buffer mutational variations
score: 0.51869718, Nature chemical biology, 2012, Bandyopadhyay, Anannya et. al.
CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
score: 0.51840534, Nature chemical biology, 2011, Urizar, Eneko et. al.
Oxidation of liposomal membrane suppressed by flavonoids: Quantitative structure–activity relationship
score: 0.51768656, Bioorganic & Medicinal Chemistry, 2005, Rackova, Lucia et. al.
Hit finding: towards ‘smarter’ approaches
score: 0.51757442, Current Opinion in Pharmacology, 2009, Langer, Thierry et. al.
Charging the batteries to heal wounds through PI3K.
score: 0.51746726, Nature chemical biology, 2006, Vanhaesebroeck, Bart
PI(3) kinases: revealing the delta lady.
score: 0.51743785, Nature chemical biology, 2010, Workman, Paul; van Montfort, Rob L M
A single thiourea group is not enough to get stable thiourea lipoplexes
score: 0.51705362, Bioorganic & Medicinal Chemistry, 2008, Kabha, Eihab et. al.
Pulling NO out of thin air.
score: 0.51679642, Nature chemical biology, 2005, Spiro, Thomas G
Synthesis, Conformation and T-Helper Cell Stimulation of an O-Linked Glycopeptide Epitope Containing Extended Carbohydrate Side-Chains
score: 0.51617009, Bioorganic & Medicinal Chemistry, 2002, Cudic, Mare; Ertl, Hildegund C.J; Otvos, Laszlo
Discovery of a new 'dynasore'.
score: 0.51595701, Nature chemical biology, 2006, Thompson, Heather M; McNiven, Mark A
The biology and chemistry of antifungal agents: A review
score: 0.5154876, Bioorganic & Medicinal Chemistry, 2012, Kathiravan, Muthu K et. al.
Greasing the gears of potassium channels.
score: 0.51523434, Nature chemical biology, 2006, Swartz, Kenton J
Synthesis, characterisation, activities, cell uptake and DNA binding of [{ trans-PtCl(NH 3) 2} {μ-(H 2N(CH 2) 6NH 2)} { trans-PdCl(NH 3) 2](NO 3)Cl
score: 0.51506668, European Journal of Medicinal Chemistry, 2004, Huq, Fazlul et. al.
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.
score: 0.51503546, Nature chemical biology, 2010, Albizu, Laura et. al.
Structural and mechanistic basis for a novel mode of glycosyltransferase inhibition
score: 0.51449326, Nature chemical biology, 2010, Pesnot, Thomas et. al.
Structure-based design of anti-infectives.
score: 0.51414065, Annals of the New York Academy of Sciences, 2010, Agarwal, Anil K; Fishwick, Colin W G
Convenient chemoenzymatic synthesis of β-purine-diphosphate sugars (GDP-fucose-analogues)
score: 0.51412228, Bioorganic & Medicinal Chemistry, 1997, Baisch, Gabi; Öhrlein, Reinhold
A natural ribozyme with 3',5' RNA ligase activity.
score: 0.51409832, Nature chemical biology, 2009, Vicens, Quentin; Cech, Thomas R
1-Substituted-4-[3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl]piperazines: influence of the N-1 piperazine substituent on 5-HT 1A receptor affinity and selectivity versus D 2 and α 1 receptors. Part 6
score: 0.51361379, Bioorganic & Medicinal Chemistry, 2000, Perrone, Roberto et. al.
Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol.
score: 0.51302402, Nature chemical biology, 2011, Yim, Harry et. al.
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.
score: 0.51294573, Nature chemical biology, 2012, Yuzwa, Scott A et. al.
Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type b receptor antagonists
score: 0.51275431, Bioorganic & Medicinal Chemistry, 1994, Bock, Mark G. et. al.
The connectivity map.
score: 0.51224795, Nature chemical biology, 2006, Michnick, Stephen W
Nitrite-methemoglobin inadequate for hypoxic vasodilation.
score: 0.51218985, Nature chemical biology, 2009, Schwab, David E; Stamler, Jonathan S; Singel, David J
KM-01, a brassinolide inhibitor, its production, isolation and structure from two fungi Drechslera avenae and Pycnoporus coccineus
score: 0.5117939, Bioorganic & Medicinal Chemistry, 1998, Kim, Seong-kie et. al.
Fluorescent chemosensing of catechol and catecholamines in water
score: 0.51178169, Bioorganic & Medicinal Chemistry, 1993, Yoon, Juyoung; Czarnik, Anthony W.
Synthesis and vasorelaxant activity of 4-(cyclic amido)-2 H-naphtho[1,2- b]pyrans
score: 0.51164676, European Journal of Medicinal Chemistry, 2002, Chiou, Wen-Fei et. al.
Plant biology: Blocking galactolipid biosynthesis.
score: 0.51072576, Nature chemical biology, 2011, Chapman, Kent D
Peering inside the black box to find enzyme-bound intermediates.
score: 0.51023491, Nature chemical biology, 2008, Townsend, Craig
Searching for a wrench to throw into the splicing machine.
score: 0.51000003, Nature chemical biology, 2008, Jurica, Melissa S
Mechanism of 3-methylaspartase probed using deuterium and solvent isotope effects and active-site directed reagents: identification of an essential cysteine residue
score: 0.50995768, Bioorganic & Medicinal Chemistry, 1999, Pollard, John R. et. al.
Genetically encoded molecules for inducibly inactivating CaV channels.
score: 0.50952332, Nature chemical biology, 2007, Yang, Tingting et. al.
Synthesis, structure–activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives
score: 0.50948861, European Journal of Medicinal Chemistry, 2005, Pękala, Elżbieta et. al.
Synthesis and biological activities of the marine bryozoan alkaloids convolutamines A, C and F, and lutamides A and C
score: 0.50931611, Bioorganic & Medicinal Chemistry, 2000, Hashima, Hirofumi et. al.
Novel Allosteric Sites on Ras for Lead Generation
score: 0.50920138, PLoS ONE, 2011, Grant, Barry J. et. al.
Effect of Polymer Grafting Density on Silica Nanoparticle Toxicity
score: 0.50918534, Bioorganic & Medicinal Chemistry, 2012, Lin, I-Chun et. al.
Bioisosterism in drug design: Identification of and structure-activity relationships in a series of glycine anilide ACAT inhibitors
score: 0.50906042, Bioorganic & Medicinal Chemistry, 1995, Howard Roark, W. et. al.
Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog
score: 0.50880924, Bioorganic & Medicinal Chemistry, 2006, Aneja, Ritu; Vangapandu, Surya N.; Joshi, Harish C.
Identification of 12Cysβ on tubulin as the binding site of tubulyzine
score: 0.50832612, Bioorganic & Medicinal Chemistry, 2006, Kim, Yeoun Jin et. al.
Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: Development of a divergent strategy for the total synthesis of duocarmycins A and SA
score: 0.50814081, Bioorganic & Medicinal Chemistry, 1995, Boger, Dale L.; Nishi, Takahide
Synthesis of azasugars as potent inhibitors of glycosidases
score: 0.50796763, Bioorganic & Medicinal Chemistry, 1997, Le Merrer, Yves et. al.
Chemical glycobiology: why now?
score: 0.5079279, Nature chemical biology, 2009, Seeberger, Peter H
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.
score: 0.50771623, Nature chemical biology, 2012, Sajish, Mathew et. al.
Marlene Haffner.
score: 0.50751716, Nature chemical biology, 2006, Goodman, Catherine
The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol.
score: 0.50731455, Nature chemical biology, 2007, Netz, Daili J A et. al.
A Review of Solid-Phase Organic Synthesis on SynPhase™ Lanterns and SynPhase™ Crowns
score: 0.5070577, Methods in Enzymology, 2003, Parsons, Jack G et. al.
Molecular Determinants of Juvenile Hormone Action as Revealed by 3D QSAR Analysis in Drosophila
score: 0.50689316, PLoS ONE, 2009, Liszeková, Denisa et. al.
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
score: 0.50548983, Nature chemical biology, 2008, O’Maille, P.E. et. al.
Enzymology: Radical break-up, blissful make-up.
score: 0.50518699, Nature chemical biology, 2011, Arcinas, Arthur J; Booker, Squire J
Construction of a chemically and conformationally self-replicating system of amyloid-like fibrils
score: 0.50477335, Bioorganic & Medicinal Chemistry, 2004, Takahashi, Yuta; Mihara, Hisakazu
Bioinorganic chemistry: electrons in Fe-S protein assembly.
score: 0.50450546, Nature chemical biology, 2010, Dos Santos, Patricia C; Dean, Dennis R
Sugars synthesized in a snap.
score: 0.50411694, Nature chemical biology, 2007, Wang, Peng George
[ 18 F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
score: 0.50362359, Bioorganic & Medicinal Chemistry, 2012, Philippe, Cécile et. al.
The interaction of glycine, aspartic acid, and lysine by the protonated macrocyclic ligand 6,19-bis(2-hydroxypropyl)-3,6,9,16,19,22-hexaaza-tricyclo-[22.2.2.2 11,14]triaconta-11,13,24,26,27,29-hexaene
score: 0.50351065, Bioorganic & Medicinal Chemistry, 2004, Huang, Jin et. al.
Enantioselective formation of ( R)-9-HPODE and ( R)-9-HPOTrE in marine green alga Ulva conglobata
score: 0.50324972, Bioorganic & Medicinal Chemistry, 2002, Akakabe, Yoshihiko; Matsui, Kenji; Kajiwara, Tadahiko
3D-QSAR Studies on Thiazolidin-4-one S1P 1 Receptor Agonists by CoMFA and CoMSIA
score: 0.5030883, International Journal of Molecular Sciences, 2011, Qian, Chuiwen et. al.
Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen
score: 0.50300396, Nature Chemical Biology, 2011, Laggner, Christian et. al.
S-nitrosylation TRiPs a calcium switch.
score: 0.50298885, Nature chemical biology, 2006, Foster, Matthew W; Hess, Douglas T; Stamler, Jonathan S
Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions
score: 0.50285641, European Journal of Medicinal Chemistry, 2003, Jansen, Michaela; Dannhardt, Gerd
Ureide catabolism in Arabidopsis thaliana and Escherichia coli.
score: 0.50283234, Nature chemical biology, 2010, Werner, Andrea K; Romeis, Tina; Witte, Claus-Peter
Immobilisation on polystyrene of diazirine derivatives of mono- and disaccharides: biological activities of modified surfaces
score: 0.50237727, Bioorganic & Medicinal Chemistry, 2001, Chevolot, Y et. al.
Diesters of glycosylglycerols active in cancer chemoprevention
score: 0.50216119, European Journal of Medicinal Chemistry, 2001, Colombo, Diego et. al.
Synthesis and antitrypanosomal activities of a series of 7-deaza-5'-noraristeromycin derivatives with variations in the cyclopentyl ring substituents.
score: 0.50192232, Antimicrobial agents and chemotherapy, 1997, Seley, K L et. al.
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1.
score: 0.50157341, Antimicrobial agents and chemotherapy, 1992, Balzarini, J et. al.
Chemical synthesis and biological investigation of a 77-mer oligoribonucleotide with a sequence corresponding to E. coli tRNA Asp
score: 0.50152249, Bioorganic & Medicinal Chemistry, 2001, Persson, Tina et. al.
Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: synthesis and determination of affinities at D 2, 5-HT 2A, 5-HT 2B and 5-HT 2C receptors # # Presented in part at the XVth International Symposium on Medicinal Chemistry, Edinburgh, UK, September, 1998. 21st paper in the series “Synthesis and CNS activity of conformationally restricted butyrophenones”. For preceding papers see [39].
score: 0.50130548, European Journal of Medicinal Chemistry, 2000, Masaguer, Christian F. et. al.
Stimulating the cell's appetite for itself.
score: 0.501206, Nature chemical biology, 2007, Simonsen, Anne; Stenmark, Harald
RF1 Knockout Allows Ribosomal Incorporation of Unnatural Amino Acids at Multiple Sites
score: 0.50114636, Nature Chemical Biology, 2011, Johnson, David B.F. et. al.
Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability
score: 0.50101052, European Journal of Medicinal Chemistry, 2004, Ouadi, Ali et. al.
Engineering a multipurpose catalyst.
score: 0.50054326, Nature chemical biology, 2006, Kazlauskas, Romas J
3- O-Substituted benzyl pyridazinone derivatives as COX inhibitors
score: 0.50040653, European Journal of Medicinal Chemistry, 2002, Chintakunta, Vamsee Krishna et. al.
Synthesis, characterization and anticonvulsant activity of enaminones. Part 6: Synthesis of substituted vinylic benzamides as potential anticonvulsants
score: 0.50019393, Bioorganic & Medicinal Chemistry, 1999, Foster, James E. et. al.
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.
score: 0.49989424, Nature chemical biology, 2012, Grzegorzewicz, Anna E et. al.
Fluorine-18 labeled galactosyl-neoglycoalbumin for imaging the hepatic asialoglycoprotein receptor
score: 0.49909368, Bioorganic & Medicinal Chemistry, 2009, Yang, Wenjiang et. al.
Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping.
score: 0.49909091, Chemical biology & drug design, 2010, Begley, Darren W; Zheng, Suxin; Varani, Gabriele
Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.
score: 0.49876385, The FEBS journal, 2010, Bonham, Kevin et. al.
Conformationally constrained analogues of diacylglycerol (DAG)-II. Differential interaction of δ-lactones and γ-lactones with protein kinase C (PK-C)
score: 0.49822299, Bioorganic & Medicinal Chemistry, 1993, Lee, Jeewoo et. al.
Mammalian circadian signaling networks and therapeutic targets.
score: 0.49817006, Nature chemical biology, 2007, Liu, Andrew C; Lewis, Warren G; Kay, Steve A
Effect of the chloro-substitution on lowering diabetic hyperglycemia of vanadium complexes with their permeability and cytotoxicity
score: 0.4971941, European Journal of Medicinal Chemistry, 2010, Xie, Ming-Jin et. al.
Directed Sorting Approach for the Synthesis of Large Combinatorial Libraries of Discrete Compounds
score: 0.49715698, Methods in Enzymology, 2003, Herpin, Timothy F; Morton, George C
Synthesis of the lipoteichoic acid of the Streptococcus species DSM 8747
score: 0.4969753, Bioorganic & Medicinal Chemistry, 2010, Qiao, Yan et. al.
Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein Association
score: 0.49668158, Chemistry & Biology, 2006, Sachchidanand, et. al.
Substituted benzopyranobenzothiazinones. Synthesis and estrogenic activity on MCF-7 breast carcinoma cells
score: 0.4963774, European Journal of Medicinal Chemistry, 2001, Jacquot, Yves et. al.
Use of enzyme penicillin acylase in selective amidation/amide hydrolysis to resolve ethyl 3-amino-4-pentynoate isomers
score: 0.49632578, Bioorganic & Medicinal Chemistry, 1999, Topgi, Ravindra S. et. al.
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.
score: 0.49583443, Nature chemical biology, 2006, Shiva, Sruti et. al.
Antitumor agents—CLI. Bis(helenalinyl)glutarate and bis(isoalantodiol-B)glutarate, potent inhibitors of human DNA topoisomerase II
score: 0.49578215, Bioorganic & Medicinal Chemistry, 1994, Chen, Chung-Hsiung et. al.
Microscopic rotary mechanism of ion translocation in the F(o) complex of ATP synthases.
score: 0.4956741, Nature chemical biology, 2010, Pogoryelov, Denys et. al.
Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination
score: 0.49502068, Nature chemical biology, 2010, Zhang, Qi et. al.
Molecular modeling of blood–brain barrier nutrient transporters: In silico basis for evaluation of potential drug delivery to the central nervous system
score: 0.49496255, Life Sciences, 2006, Allen, David D.; Geldenhuys, Werner J.
Protein aggregation: p53 succumbs to peer pressure.
score: 0.4949303, Nature chemical biology, 2011, Magzoub, Mazin; Miranker, Andrew D
Inactivation of monoamine oxidase B by cis- and trans-5-aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3 H)-ones
score: 0.49466753, Bioorganic & Medicinal Chemistry, 1998, Lu, Xingliang; Silverman, Richard B
Lipids: PI couples voltage to catalysis.
score: 0.49435431, Nature chemical biology, 2010, Okamura, Yasushi
Optimization of a blueprint for in vitro glycolysis by metabolic real-time analysis.
score: 0.49432873, Nature chemical biology, 2011, Bujara, Matthias et. al.
Taxus canadensis abundant taxane: conversion to paclitaxel and rearrangements
score: 0.4942775, Bioorganic & Medicinal Chemistry, 2000, Nikolakakis, Anastasia et. al.
Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative
score: 0.49377054, Bioorganic & Medicinal Chemistry, 1994, Jimonet, P. et. al.
Directed Sorting Approach for the Synthesis of Large Combinatorial Libraries of Discrete Compounds
score: 0.49345095, Methods in Enzymology, 2003, Herpin, Timothy F; Morton, George C
Targeting of Polyplex to Human Hepatic Cells by Bio-nanocapsules, Hepatitis B Virus Surface Antigen L Protein Particles
score: 0.49341281, Bioorganic & Medicinal Chemistry, 2012, Somiya, Masaharu et. al.
Synthesis and antitrypanosomal evaluation of E -isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. Structure–activity relationships.
score: 0.49316948, European Journal of Medicinal Chemistry, 2000, Cerecetto, Hugo et. al.
An active role for machine learning in drug development.
score: 0.49259321, Nature chemical biology, 2011, Murphy, Robert F
Cannabinoid receptor type 2 (CB2)-selective N -aryl-oxadiazolyl-propionamides: synthesis, radiolabelling, molecular modelling and biological evaluation
score: 0.4924925, Organic and Medicinal Chemistry Letters, 2012, Rühl, Thomas et. al.
Regulation of CK2 by Phosphorylation and O-GlcNAcylation Revealed by Semisynthesis
score: 0.4922826, Nature Chemical Biology, 2011, Tarrant, Mary Katherine et. al.
Hit and lead generation: beyond high-throughput screening.
score: 0.49176544, Nature reviews. Drug discovery, 2003, Bleicher, Konrad H et. al.
2,4-Decadienals are produced via ( R)-11-HPITE from arachidonic acid in marine green alga Ulva conglobata
score: 0.49174248, Bioorganic & Medicinal Chemistry, 2003, Akakabe, Yoshihiko; Matsui, Kenji; Kajiwara, Tadahiko
Antibiotics: vancomycin sensing.
score: 0.49144932, Nature chemical biology, 2010, Arthur, Michel
RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites.
score: 0.49114646, Nature chemical biology, 2011, Johnson, David B F et. al.
The challenges of integrating multi-omic data sets.
score: 0.49106147, Nature chemical biology, 2010, Palsson, Bernhard; Zengler, Karsten
Synthesis of new pyridazinone derivatives and their affinity towards α 1–α 2-adrenoceptors
score: 0.49071576, Bioorganic & Medicinal Chemistry, 1999, Corsano, Stefano et. al.
Challenges in studying phospholipid signaling.
score: 0.49055727, Nature chemical biology, 2010, Schultz, Carsten
New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA
score: 0.49045625, Bioorganic & Medicinal Chemistry, 2008, Miller, Gregory P.; Silverman, Adam P.; Kool, Eric T.
Calcium channels light up.
score: 0.49041264, Nature chemical biology, 2007, Green, Eric; Dolmetsch, Ricardo E
The impact of microwave-assisted organic synthesis in drug discovery
score: 0.49031695, Drug Discovery Today, 2006, Mavandadi, Farah; Pilotti, Åke
Feasible synthesis and biological properties of six ‘non-glycosamino’ glycan analogues of the antithrombin III binding heparin pentasaccharide
score: 0.49026328, Bioorganic & Medicinal Chemistry, 1994, Westerduin, P. et. al.
Synthetic GPI array to study antitoxic malaria response.
score: 0.48984693, Nature chemical biology, 2008, Kamena, Faustin et. al.
Synthesis, azido-tetrazole equilibrium studies and biological activity of 1-(2-azido-6-chloropyrid-4-yl)-3-phenylurea, a photoaffinity labeling reagent for cytokinin-binding proteins
score: 0.48973677, Bioorganic & Medicinal Chemistry, 1995, Dias, Marylène; Mornet, René; Laloue, Michel
Evolution of efficient pathways for degradation of anthropogenic chemicals.
score: 0.48958648, Nature chemical biology, 2009, Copley, Shelley D
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.
score: 0.48950005, Nature chemical biology, 2011, Ejim, Linda et. al.
The synthesis of 2 ′ -methylseleno adenosine and guanosine 5 ′ -triphosphates
score: 0.48939584, Bioorganic & Medicinal Chemistry, 2012, Santner, Tobias et. al.
The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3
score: 0.4893898, Bioorganic & Medicinal Chemistry, 1995, Groutas, William C. et. al.
Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey.
score: 0.489339, Nature chemical biology, 2005, Sorensen, Peter W et. al.
Chemical genetic modification of Ca2+ channel activity.
score: 0.48916762, Nature chemical biology, 2007, Nitabach, Michael
Substrate selection by the proteasome during degradation of protein complexes.
score: 0.48899794, Nature chemical biology, 2009, Prakash, Sumit et. al.
N-substituted aminohydroxypyridines as potential non-opioid analgesic agents
score: 0.48885635, Bioorganic & Medicinal Chemistry, 1995, Viaud, M.C. et. al.
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells
score: 0.48874104, Nature chemical biology, 2011, Gloster, Tracey M. et. al.
Bioaccumulation and localization of exogenous cadmium in a teleost by electron microscopy (TEM) and its specific quantitation by electron probe X-ray microanalysis (EPMA)
score: 0.488602, Bioorganic & Medicinal Chemistry, 2000, Tayal, Ashesh K; Kaur, Inderjeet; Mathur, R.P
Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation.
score: 0.4884071, Nature chemical biology, 2007, Huq, M D Mostaqul et. al.
Our paper anniversary.
score: 0.4881239, Nature chemical biology, 2006,
Reaction design: Nature-inspired total synthesis.
score: 0.48804179, Nature chemical biology, 2011, Furst, Laura; Stephenson, Corey R J
Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin
score: 0.48793663, Bioorganic & Medicinal Chemistry, 1995, Lin, Chun-Hung et. al.
Chemical approaches to the investigation of cellular systems
score: 0.48773464, Bioorganic & Medicinal Chemistry, 2002, Cook, Brian N.; Bertozzi, Carolyn R.
Synthesis and inhibitory activity of glycosidase inhibitors, glycosylamino-oxazolines
score: 0.48764391, Bioorganic & Medicinal Chemistry, 1996, Uchida, Chikara; Ogawa, Seiichiro
The academic pursuit of screening.
score: 0.48730553, Nature chemical biology, 2007,
N-tetrachlorophthaloyl (TCP) for ready protection/deprotection of amino sugar glycosides
score: 0.48717485, Bioorganic & Medicinal Chemistry, 1996, Debenham, John S; Debenham, Sheryl D; Fraser-Reid, Bert
Extensive Ligand-Based Modeling And In Silico Screening Reveal Nanomolar Inducible Nitric Oxide Synthase (iNOS) Inhibitors
score: 0.48650551, Journal of Molecular Graphics and Modelling, 2012, Suaifan, Ghadeer A.R.Y. et. al.
Assembling the pieces.
score: 0.48639138, Nature chemical biology, 2008, Thiele, Dennis J; Gitlin, Jonathan D
Submitting antibodies to binding arbitration.
score: 0.48546321, Nature chemical biology, 2008, Michnick, Stephen W; Sidhu, Sachdev S
The selective enzymatic synthesis of lipophilic esters of swainsonine
score: 0.48521309, Bioorganic & Medicinal Chemistry, 1999, Perrone, Gabriel G.; Barrow, Kevin D.; McFarlane, Ian J.
A biosensor generated via high throughput screening quantifies cell edge Src dynamics
score: 0.48510702, Nature chemical biology, 2011, Gulyani, Akash et. al.
Discovery of new antifungal leads via pharmacophore modeling and QSAR analysis of fungal N-myristoyl transferase inhibitors followed by in silico screening.
score: 0.48488219, Chemical biology & drug design, 2011, Taha, Mutasem O et. al.
Investigations using immunization to attenuate the psychoactive effects of nicotine
score: 0.48474397, Bioorganic & Medicinal Chemistry, 2004, Carrera, M.Rocı́o A et. al.
A bridge between chemistry and biology.
score: 0.48472726, Nature chemical biology, 2006, Kikuchi, Kazuya; Kakeya, Hideaki
A Class of Tricyclic Compounds Blocking Malaria Oocyst Development and Transmission.
score: 0.4842551, Antimicrobial agents and chemotherapy, 2012, Eastman, Richard T et. al.
A century at the chemistry-biology interface.
score: 0.48363557, Nature chemical biology, 2006, Kohler, Jennifer J
Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.
score: 0.4836069, Antimicrobial agents and chemotherapy, 1995, Chu, C K et. al.
Molecular frontiers.
score: 0.48349101, Nature chemical biology, 2007, Kotz, Joanne
Novel substituted quinoxaline 1,4-dioxides with in vitro antimycobacterial and anticandida activity
score: 0.48329547, European Journal of Medicinal Chemistry, 2002, Carta, Antonio et. al.
Carbonic anhydrase inhibitors – Part 78 # # See ref. [1]. This paper is dedicated to the memory of Tom Maren (1917–1999) who contributed important discoveries to the field of carbonic anhydrase inhibitors. . Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route
score: 0.4831306, European Journal of Medicinal Chemistry, 2000, Supuran, Claudiu T. et. al.
Highly active and selective endopeptidases with programmed substrate specificities.
score: 0.48262316, Nature chemical biology, 2008, Varadarajan, Navin et. al.
Cardiac glycosides are potent inhibitors of interferon-β gene expression
score: 0.48181902, Nature chemical biology, 2010, Ye, Junqiang; Chen, Shuibing; Maniatis, Tom
Syntheses, activity and modeling studies of 3- and 4-(sulfo- and sulfonamidoalkyl)pyridine and piperidine-2-carboxylic acid derivatives as analogs of NMDA receptor antagonists
score: 0.48073553, Bioorganic & Medicinal Chemistry, 1995, El Hadri, Ahmed et. al.
Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses.
score: 0.48068836, Nature chemical biology, 2012, Lawrence, Roger et. al.
Glycosyl-oxycarbonylaminosulfonyl-2′ ,3′-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity
score: 0.48039757, Bioorganic & Medicinal Chemistry, 1993, Pérez-Pérez, María-Jesús et. al.
Chemical biology at the crossroads of molecular structure and mechanism.
score: 0.48031668, Nature chemical biology, 2005, Doudna, Jennifer A
An emerging role for chemical biology.
score: 0.48024764, Nature chemical biology, 2005,
Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes
score: 0.48023995, Nature Chemical Biology, 2011, Netz, Daili J. A. et. al.
A synthetic heparan sulfate pentasaccharide, exclusively containing l-iduronic acid, displays higher affinity for FGF-2 than its d-glucuronic acid-containing isomers
score: 0.47994861, Bioorganic & Medicinal Chemistry, 1999, Kovensky, José et. al.
Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease
score: 0.47975107, Journal of Molecular Graphics and Modelling, 2013, Chen, Shi-Gao; Gu, Ruo-Xu; Dai, Hao; Wei, Dong-Qing
Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease
score: 0.47975107, Journal of Molecular Graphics and Modelling, 2013, Chen, Shi-Gao; Gu, Ruo-Xu; Dai, Hao; Wei, Dong-Qing
Simultaneous binding of a polyamide dimer and an oligonucleotide in the minor and major grooves of DNA
score: 0.47882746, Bioorganic & Medicinal Chemistry, 1996, Parks, Michelle E.; Dervan, Peter B.
FERM domain interaction with myosin negatively regulates FAK in cardiomyocyte hypertrophy.
score: 0.47866925, Nature chemical biology, 2012, Santos, Aline M et. al.
Epsilon-poly-L-lysine dispersity is controlled by a highly unusual nonribosomal peptide synthetase.
score: 0.47769438, Nature chemical biology, 2008, Yamanaka, Kazuya et. al.
CODA-RET reveals functional selectivity as a result of GPCR heteromerization
score: 0.47764938, Nature chemical biology, 2011, Urizar, Eneko et. al.
Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem.
score: 0.47739506, Nature chemical biology, 2009, Song, Hao; Payne, Stephen; Gray, Meagan; You, Lingchong
Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem
score: 0.47739506, Nature chemical biology, 2009, Song, Hao; Payne, Stephen; Gray, Meagan; You, Lingchong
Synthesis and molecular recognition of carbohydrate-centered multivalent glycoclusters by a plant lectin RCA 120
score: 0.47737006, Bioorganic & Medicinal Chemistry, 2005, Gao, Yongjun; Eguchi, Atsuko; Kakehi, Kazuaki; Lee, Yuan C.
Retromer terminates the generation of cAMP by internalized PTH receptors.
score: 0.47734675, Nature chemical biology, 2011, Feinstein, Timothy N et. al.
A biosensor generated via high-throughput screening quantifies cell edge Src dynamics.
score: 0.47733686, Nature chemical biology, 2011, Gulyani, Akash et. al.
High-throughput assay for small molecules that modulate zebrafish embryonic heart rate.
score: 0.47694769, Nature chemical biology, 2005, Burns, C Geoffrey et. al.
Further chemical modification of trehalase inhibitor trehazolin: Structure and inhibitory-activity relationship of the inhibitor
score: 0.47683805, Bioorganic & Medicinal Chemistry, 1995, Uchida, Chikara et. al.
purification and characterization of extracellular lipases from ophiostoma piliferum
score: 0.47635781, Bioorganic & Medicinal Chemistry, 1999, Brush, Theresa S et. al.
Amyloid-β Forms Fibrils by Nucleated Conformational Conversion of Oligomers
score: 0.47554817, Nature chemical biology, 2011, Lee, Jiyong et. al.
Synthesis and Evaluation of 1-(1-(Benzo[ b ]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase
score: 0.47509546, Chemmedchem, 2009, Patterson, Stephen et. al.
Bifunctional derivative of p, p′-dichlorochalcone
score: 0.47461146, European Journal of Medicinal Chemistry, 2002, Singh, Shishu Pal et. al.
Synthetic translational regulation by an L7Ae-kink-turn RNP switch.
score: 0.47393812, Nature chemical biology, 2010, Saito, Hirohide et. al.
ABC proteins in antigen translocation and viral inhibition.
score: 0.4733668, Nature chemical biology, 2010, Parcej, David; Tampé, Robert
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.
score: 0.47281207, Nature chemical biology, 2009, Dansen, Tobias B et. al.
Synthesis and in vitro antibacterial activity of spermidine-based mixed catechol- and hydroxamate-containing siderophore—Vancomycin conjugates
score: 0.47253621, Bioorganic & Medicinal Chemistry, 1996, Ghosh, Manuka; Miller, Marvin J.
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin.
score: 0.47238294, Nature chemical biology, 2007, Basu, Swati et. al.
New nepenthone and thevinone derivatives
score: 0.47228722, Bioorganic & Medicinal Chemistry, 1997, Marton, János et. al.
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'.
score: 0.47155997, Nature chemical biology, 2008, Kastrup, Christian J et. al.
Synthesis and antifungal activity of novel pyrazolecarboxamide derivatives containing a hydrazone moiety
score: 0.47154791, Chemistry Central Journal, 2012, Wu, Jian et. al.
The effect on quadruplex stability of North-nucleoside derivatives in the loops of the thrombin-binding aptamer
score: 0.47131681, Bioorganic & Medicinal Chemistry, 2012, Aviñó, Anna et. al.
The effect on quadruplex stability of North-Nucleoside derivatives in the loops of the thrombin-binding aptamer
score: 0.47131681, Bioorganic & Medicinal Chemistry, 2012, Aviñó, Anna et. al.
The effect on quadruplex stability of North-nucleoside derivatives in the loops of the thrombin-binding aptamer
score: 0.47131681, Bioorganic & Medicinal Chemistry, 2012, Aviñó, Anna et. al.
Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2
score: 0.47097838, Nature Chemical Biology, 2011, Deng, Xianming et. al.
Introducing a C-interglycosidic bond in a biologically active pentasaccharide hardly affects its biological properties
score: 0.47072272, Bioorganic & Medicinal Chemistry, 1998, Petitou, Maurice et. al.
Characterization of a catalytic antibody for stereoselective ester hydrolysis—a catalytic residue and mode of product inhibition
score: 0.47049744, Bioorganic & Medicinal Chemistry, 1994, Nakatani, Takuji et. al.
The inorganic side of chemical biology.
score: 0.47043907, Nature chemical biology, 2006, Lippard, Stephen J
Possible new RNA intermediate in RNA silencing.
score: 0.47017024, Nature chemical biology, 2009, Elkashef, Samer; Ding, Shou-Wei
Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids
score: 0.46994463, Nature Chemical Biology, 2011, Long, Jonathan Z. et. al.
Synthesis of key sandramycin analogs: systematic examination of the intercalation chromophore
score: 0.46982889, Bioorganic & Medicinal Chemistry, 1998, Boger, Dale L.; Chen, Jyun-Hung; Saionz, Kurt W.; Jin, Qing
Synthesis of bis-γ-butyrolactones containing conformationally constrained ( S)- and ( R)-diacylglycerol structures
score: 0.46802284, Bioorganic & Medicinal Chemistry, 1996, Lee, Jeewoo et. al.
Synthesis and biological activity of 6 H-isoindolo[2,1- a]indol-6-ones, analogues of batracylin, and related compounds
score: 0.46765879, European Journal of Medicinal Chemistry, 2006, Guillaumel, Jean et. al.
Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.
score: 0.46701252, Nature chemical biology, 2012, Rigo, Frank et. al.
Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation
score: 0.46687029, European Journal of Medicinal Chemistry, 2000, Arty, Indyah S et. al.
Synthesis and anti-HIV activity of new urea and nitrosourea derivatives of diamino acids
score: 0.46652997, Bioorganic & Medicinal Chemistry, 1995, Dulude, Hélène; Salvador, Romano; Gallant, Gilles
Structure-based screening of low-affinity compounds
score: 0.46638202, Drug Discovery Today, 2002, Carr, Robin; Jhoti, Harren
Metabolic oxidation regulates embryonic stem cell differentiation.
score: 0.46630286, Nature chemical biology, 2010, Yanes, Oscar et. al.
Substrate specificity of the bovine serum amine oxidase and in situ characterisation of aminoaldehydes by NMR spectroscopy
score: 0.46599972, Bioorganic & Medicinal Chemistry, 2005, Houen, Gunnar et. al.
Enantioselective deoxygenation of alkyl aryl sulfoxides by DMSO reductase from Rhodobacter sphaeroides f.s. denitrificans
score: 0.46546483, Bioorganic & Medicinal Chemistry, 1995, Abo, Mitsuru et. al.
Perspectives on NMR in drug discovery: a technique comes of age.
score: 0.46536624, Nature reviews. Drug discovery, 2008, Pellecchia, Maurizio et. al.
Mannoside hydrolysis: it's a boat!
score: 0.4653078, Nature chemical biology, 2008,
A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.
score: 0.46480894, Nature chemical biology, 2010, Koteva, Kalinka et. al.
The ABCs of trans(porter) inhibition.
score: 0.46474439, Nature chemical biology, 2008, Gaudet, Rachelle
Heterogeneity in the chemistry, structure and function of plant cell walls.
score: 0.46458639, Nature chemical biology, 2010, Burton, Rachel A; Gidley, Michael J; Fincher, Geoffrey B
An update on sphingosine-1-phosphate and other sphingolipid mediators.
score: 0.46436026, Nature chemical biology, 2010, Fyrst, Henrik; Saba, Julie D
Novel bishydroxamic acids as 5-lipoxygenase inhibitors
score: 0.46406588, Bioorganic & Medicinal Chemistry, 1994, Ohemeng, Kwasi A. et. al.
Exploring the interest of 1,2-Dithiolane ring system in peptide chemistry. Synthesis of a chemotactic tripeptide and x-ray crystal structure of a 4-amino-1,2-dithiolane-4-carboxylic acid derivative
score: 0.46389665, Bioorganic & Medicinal Chemistry, 2002, Morera, Enrico et. al.
Synthesis and screening of antibacterial and antifungal activity of 5-chloro-1,3-benzoxazol-2(3 h)-one derivatives
score: 0.46348613, Organic and Medicinal Chemistry Letters, 2012, Modiya, Priya R; Patel, Chhaganbhai N
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
score: 0.46318902, Molecular pharmacology, 2010, Rodriguez, Alice L et. al.
Synthesis and properties of oligonucleotides containing the mutagenic base O 4-benzylthymidine
score: 0.46288485, Bioorganic & Medicinal Chemistry, 1995, Fabrega, Carme et. al.
Synthesis of [ 18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)- N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia
score: 0.46282408, Bioorganic & Medicinal Chemistry, 2001, Josse, Olivier et. al.
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis.
score: 0.46274879, Nature chemical biology, 2008, Jansson, Emmelie A et. al.
Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4
score: 0.46252985, Nature Chemical Biology, 2011, Hothorn, Michael; Dabi, Tsegaye; Chory, Joanne
Cutting the forest to see a single tree?
score: 0.46092418, Nature chemical biology, 2008, van Oijen, Antoine M
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
score: 0.45996276, Nature chemical biology, 2012, Khare, Sagar D et. al.
Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21
score: 0.45985863, Nature chemical biology, 2011, Wang, Yuefeng et. al.
Hit identification of IKKβ natural product inhibitor
score: 0.45944997, BMC Pharmacology & Toxicology, 2013, Leung, Chung-Hang et. al.
Rethinking relationships between natural products.
score: 0.45927238, Nature chemical biology, 2007, Schreiber, Stuart L
5-(Trifluoromethyl)-β- l-2′-deoxyuridine, the l-Enantiomer of Trifluorothymidine: Stereospecific Synthesis and Antiherpetic Evaluations
score: 0.45911295, Bioorganic & Medicinal Chemistry, 2001, Salvetti, Raul et. al.
Synthesis of peptide analogues containing phosphonamidate methyl ester functionality: HIV-1 proteinase inhibitors possessing unique cell uptake properties
score: 0.45901016, Bioorganic & Medicinal Chemistry, 1995, Camp, Nicholas P. et. al.
Luminescent pyrimidine hydrazide oligomers with peptide affinity
score: 0.45896832, Bioorganic & Medicinal Chemistry, 2006, Li, Xiaoqiang; Miltschitzky, Stefan; König, Burkhard
Docking for fragment inhibitors of AmpC beta-lactamase.
score: 0.45892444, Proceedings of the National Academy of Sciences of the United States of America, 2009, Teotico, Denise G et. al.
Synthesis and inhibitory activity towards human leukocyte elastase of new 7α-methoxy and 7α-chloro (2-acyloxymethyl) cephem derivatives
score: 0.45884441, European Journal of Medicinal Chemistry, 2001, Balsamo, Aldo et. al.
In Vitro Bacterial Polysaccharide Biosynthesis: Defining the Functions of Wzy and Wzz
score: 0.45865884, Nature chemical biology, 2010, Woodward, Robert et. al.
Dynamics connect substrate recognition to catalysis in protein kinase A.
score: 0.45863401, Nature chemical biology, 2010, Masterson, Larry R et. al.
Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives
score: 0.458121, Bioorganic & Medicinal Chemistry, 1998, Donkor, Isaac O. et. al.
The biology and chemistry of antifungal agents: A review
score: 0.45807263, Bioorganic & Medicinal Chemistry, 2012, Kathiravan, Muthu K et. al.
Molecular recognition: O-GlcNAc transfer: size matters.
score: 0.45800179, Nature chemical biology, 2011, Gay, Laurie M; Zheng, Xiaowei; van Aalten, Daan M F
Synthesis and characterization of dendrimeric melamine cored [salen/salophFe(III)] and [salen/salophCr(III)] capped complexes and their magnetic behaviors
score: 0.45750581, Journal of Hazardous Materials, 2010, Uysal, Şaban; Koç, Ziya Erdem
Judit Puskas.
score: 0.45715974, Nature chemical biology, 2010, Goodman, Catherine
Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.
score: 0.45699214, Antimicrobial agents and chemotherapy, 1997, Eakin, A E et. al.
A LOVely view of blue light photosensing.
score: 0.45661828, Nature chemical biology, 2007, Ko, Wen-Huang; Nash, Abigail I; Gardner, Kevin H
Retooling chemical probes.
score: 0.45658101, Nature chemical biology, 2010,
Insights into the Selective Inhibition of Candida albicans Secreted Aspartyl Protease: A Docking Analysis Study
score: 0.45637231, Bioorganic & Medicinal Chemistry, 2002, Pranav Kumar, S.K.; Kulkarni, Vithal M.
Visualizing tricoordinate copper transfer.
score: 0.45625545, Nature chemical biology, 2006, Cobine, Paul A; Winge, Dennis R
Cytotoxic–antineoplastic activity of hydroquinone derivatives
score: 0.45622251, European Journal of Medicinal Chemistry, 2002, Molinari, Aurora et. al.
Cytotoxic activity and QSAR of N, N′-diarylalkanediamides
score: 0.45617102, European Journal of Medicinal Chemistry, 2001, Chacón-Garcı́a, Luis; Martı́nez, Roberto
C-Terminal capping motifs in model helical peptides
score: 0.45605958, Bioorganic & Medicinal Chemistry, 1999, Kallenbach, Neville R.; Gong, Youxiang
The integration of cell and chemical biology in protein folding.
score: 0.45589992, Nature chemical biology, 2006, Kelly, Jeffery W; Balch, William E
The future of molecular dynamics simulations in drug discovery
score: 0.45560967, Journal of Computer-Aided Molecular Design, 2011, Borhani, David W.; Shaw, David E.
Glycobiology: Challenging reaction equilibria.
score: 0.45481707, Nature chemical biology, 2011, Field, Robert A
Dissecting metal ion-dependent folding and catalysis of a single DNAzyme.
score: 0.45478377, Nature chemical biology, 2007, Kim, Hee-Kyung et. al.
Natural amino acids do not require their native tRNAs for efficient selection by the ribosome.
score: 0.45464738, Nature chemical biology, 2009, Effraim, Philip R et. al.
A practical method for targeted library design balancing lead-like properties with diversity.
score: 0.45448798, ChemMedChem, 2009, Stocks, Michael J et. al.
Chemical synthesis of scyllo-inosamine and catabolism studies in Sinorhizobium meliloti
score: 0.45350305, Bioorganic & Medicinal Chemistry, 2008, Schoffers, Elke et. al.
Three-Dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2–S100A10 Protein Interaction
score: 0.45327573, Chemmedchem, 2012, Reddy, Tummala R K et. al.
Symbiosis in chemistry and biology.
score: 0.45221612, Nature chemical biology, 2006, Murphy, Paul V; Rutledge, Peter J
Polymeric and dendrimeric pyridoxal enzyme mimics
score: 0.45201926, Bioorganic & Medicinal Chemistry, 2004, Liu, Lei; Breslow, Ronald
Se-ing into selenocysteine biosynthesis.
score: 0.45199588, Nature chemical biology, 2009, Mueller, Eugene G
Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators
score: 0.45194918, Bioorganic & Medicinal Chemistry, 2012, Takács, Daniella et. al.
Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation.
score: 0.45187007, Nature chemical biology, 2010, Clementi, Nina et. al.
4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures.
score: 0.45165999, Nature chemical biology, 2010, Forsman, Ulrika et. al.
Identification of a novel inhibitor of urokinase-type plasminogen activator.
score: 0.45154617, Molecular cancer therapeutics, 2007, Zhu, Ming et. al.
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity.
score: 0.4505031, Nature chemical biology, 2011, Paulsen, Candice E et. al.
Structure–activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity
score: 0.45013899, Bioorganic & Medicinal Chemistry, 2006, Sallem, Wafa et. al.
Further antineoplastic terpenylquinones and terpenylhydroquinones
score: 0.45010481, Bioorganic & Medicinal Chemistry, 1998, Miguel del Corral, JoséM. et. al.
Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring
score: 0.45005123, European Journal of Medicinal Chemistry, 2001, Reynolds, Robert C et. al.
AMPylation is a new post-translational modiFICation.
score: 0.44998647, Nature chemical biology, 2009, Yarbrough, Melanie L; Orth, Kim
B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities.
score: 0.44986333, ChemMedChem, 2011, Hamze, Abdallah et. al.
Preparation of the pure diastereomeric forms of S- (5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2- cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli
score: 0.44977578, Bioorganic & Medicinal Chemistry, 1993, Wu, Yong Qian; Woster, Patrick M.
Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
score: 0.44969274, European Journal of Medicinal Chemistry, 2010, Mora, María Julia; Longhi, Marcela R.; Granero, Gladys E.
Versatility of biological non-heme Fe(II) centers in oxygen activation reactions.
score: 0.44910969, Nature chemical biology, 2008, Kovaleva, Elena G; Lipscomb, John D
Efficient discovery of anti-inflammatory small molecule combinations using evolutionary computing
score: 0.44847201, Nature Chemical Biology, 2011, Small, Ben G et. al.
Solid phase synthesis of pp60 src -related phosphopeptides via ‘global’ phosphorylation and their use as substrates for enzymatic phosphorylation by casein kinase-2
score: 0.44834913, Bioorganic & Medicinal Chemistry, 1996, Perich, John W.; Meggio, Flavio; Pinna, Lorenzo A.
Cholesterol modulates glycolipid conformation and receptor activity.
score: 0.44814683, Nature chemical biology, 2011, Lingwood, Daniel et. al.
Synthesis and stereoselective κ-receptor binding of methylated analogues of GR-89.696
score: 0.44794915, European Journal of Medicinal Chemistry, 2001, Röhr, Caroline; Soukara, Stella; Wünsch, Bernhard
Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity
score: 0.44735864, Bioorganic & Medicinal Chemistry, 2005, Shi, Zhen-Dan et. al.
Reactions of purines-containing butenolides with l-cysteine or N-acetyl- l-cysteine as model biological nucleophiles: a potent mechanism-based inhibitor of ribonucleotide reductase caused apoptosis in breast carcinoma MCF7 cells
score: 0.44672341, European Journal of Medicinal Chemistry, 2002, Hakimelahi, Gholam Hossein et. al.
Protein structure: Charting a new course in coiled coils.
score: 0.44660926, Nature chemical biology, 2011, Kennan, Alan J
Template-based combinatorial enumeration of virtual compound libraries for lipids
score: 0.44637939, Journal of Cheminformatics, 2012, Sud, Manish; Fahy, Eoin; Subramaniam, Shankar
D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine.
score: 0.44572921, Nature chemical biology, 2011, Cellitti, Susan E et. al.
Stem cells: Metabolism regulates differentiation.
score: 0.44567861, Nature chemical biology, 2010, McGraw, Timothy E; Mittal, Vivek
Synthesis and preliminary evaluation of new 5-pyrazolinone derivatives as analgesic agents
score: 0.44530201, European Journal of Medicinal Chemistry, 2000, Gürsoy, Aysel et. al.
A shortcut to peptides to modulate platelets.
score: 0.44506157, Nature chemical biology, 2007, Apic, Gordana; Russell, Robert B
The biomimetic oxidation of β-1, β-0-4, β-5, and biphenyl lignin model compounds by synthetic iron porphyrins
score: 0.44424702, Bioorganic & Medicinal Chemistry, 1994, Cui, Futong; Dolphin, David
Interactions of the antibiotics neomycin B and chlortetracycline with the hammerhead ribozyme as studied by Zn 2+-dependent RNA cleavage
score: 0.44412187, Bioorganic & Medicinal Chemistry, 2004, Borda, Emily J.; Sigurdsson, Snorri Th.
Carba analogues of triglycerides—isosteric mimics for natural lipids. Novel substrates for the determination of regio- and enantioselectivities displayed by lipases
score: 0.44394884, Bioorganic & Medicinal Chemistry, 1994, Berger, Matthias; Jakob, Bernd; Schneider, Manfred P.
Quantitative structure-activity relationships of competitive inhibitors of phosphoenolpyruvate carboxylase
score: 0.4429418, Bioorganic & Medicinal Chemistry, 1995, Mancera, Ricardo L.; Gómez, Ariadne G.; Pisanty, Alejandro
N-3(9)-Arylpropenyl- N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as μ-Opioid receptor agonists. Effects on μ-Affinity of arylalkenyl chain modifications
score: 0.44283273, Bioorganic & Medicinal Chemistry, 2002, Pinna, Gérard A. et. al.
A structure-based virtual screening approach toward the discovery of histone deacetylase inhibitors: identification of promising zinc-chelating groups.
score: 0.44258364, ChemMedChem, 2010, Park, Hwangseo; Kim, Sukyoung; Kim, Yong Eun; Lim, Soo-Jeong
A convergent solid-phase synthesis of actinomycin analogues—towards implementation of double-combinatorial chemistry
score: 0.44192328, Bioorganic & Medicinal Chemistry, 1996, Tong, Glenn; Nielsen, John
In vivo selection of tumor-targeting RNA motifs
score: 0.44186677, Nature chemical biology, 2009, Mi, Jing et. al.
A natural prodrug activation mechanism in nonribosomal peptide synthesis.
score: 0.4418419, Nature chemical biology, 2011, Reimer, Daniela et. al.
Antisense therapeutics: New ways to nudge splicing.
score: 0.44138672, Nature chemical biology, 2012, Eperon, Ian
Identification of an aldose reductase inhibitor site by affinity labeling
score: 0.44106502, Bioorganic & Medicinal Chemistry, 1995, Kador, Peter F. et. al.
6 5-HT2C Ligands: Recent Progress
score: 0.44091076, Progress in Medicinal Chemistry, 2008, Monck, Nathaniel J.T.; Kennett, Guy A.
Metabolic engineering: from retrofitting to green field.
score: 0.44072407, Nature chemical biology, 2011, Nielsen, Lars K
Working towards an exegesis for lipids in biology.
score: 0.44001195, Nature chemical biology, 2009, Brown, H Alex; Murphy, Robert C
Ivano Bertini.
score: 0.43974621, Nature chemical biology, 2008, Kotz, Joanne
The role of conformational entropy in molecular recognition by calmodulin
score: 0.43938737, Nature chemical biology, 2010, Marlow, Michael S. et. al.
Lipids: LPA activates TRPV1--and it hurts.
score: 0.43779767, Nature chemical biology, 2012, Tigyi, Gabor
Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase.
score: 0.43744772, Nature chemical biology, 2011, Lee, Seung Seo et. al.
Medium-Dependence of the secondary structure of exendin-4 and glucagon-like-peptide-1
score: 0.43730849, Bioorganic & Medicinal Chemistry, 2002, Andersen, Niels H et. al.
An in vitro translation, selection and amplification system for peptide nucleic acids.
score: 0.4365683, Nature chemical biology, 2010, Brudno, Yevgeny et. al.
Looking at membrane lipids from the inside of the cell.
score: 0.4364685, Nature chemical biology, 2008, Killian, J Antoinette
Substituted 1,2,3-triazolo[1,5-a]quinazolines: synthesis and binding to benzodiazepine and adenosine receptors
score: 0.43642726, European Journal of Medicinal Chemistry, 2000, Bertelli, Lucia et. al.
Synthesis and Screening of Novel Vitamin E Derivatives for Anticancer Functions
score: 0.43585762, European Journal of Medicinal Chemistry, 2012, Chen, Wenbin et. al.
Biotin Synthesis Begins by Hijacking the Fatty Acid Synthetic Pathway
score: 0.43578879, Nature chemical biology, 2010, Lin, Steven; Hanson, Ryan E.; Cronan, John E.
Recent advances in the development of selective human MAO-B inhibitors: (Hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines
score: 0.43558813, European Journal of Medicinal Chemistry, 2012, Secci, Daniela et. al.
Recent advances in the development of selective human MAO-B inhibitors: (Hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines
score: 0.43558813, European Journal of Medicinal Chemistry, 2012, Secci, Daniela et. al.
Receptors: clicking class B GPCR ligands.
score: 0.43477911, Nature chemical biology, 2011, Sakmar, Thomas P
Relaxant activity of 2-(substituted phenyl)-1 H-benzimidazoles on isolated rat aortic rings
score: 0.43476781, Life Sciences, 2006, Estrada-Soto, Samuel et. al.
Recombinant microbial lipases for biotechnological applications
score: 0.43464281, Bioorganic & Medicinal Chemistry, 1999, Schmidt-Dannert, Claudia
β-Lactamase inhibitors derived from N-tosyloxy-β-lactams
score: 0.43464149, Bioorganic & Medicinal Chemistry, 1993, Teng, Min et. al.
Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary
score: 0.43445802, Bioorganic & Medicinal Chemistry, 1995, Nielsen, Poul; Dreiøe, Lars H; Wengel, Jesper
Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties
score: 0.43433776, Bioorganic & Medicinal Chemistry Letters, 1999, Ding, Hueisch-Jy et. al.
Synthesis of novel inhibitors of the HIV-1 protease: Difunctional enols of simple N-protected amino acids
score: 0.43394139, Bioorganic & Medicinal Chemistry, 1994, Vaillancourt, Marc et. al.
A photochemical snapshot of CD22 binding.
score: 0.433789, Nature chemical biology, 2005, Yarema, Kevin J; Sun, Zhonghui
Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds
score: 0.43376915, European Journal of Medicinal Chemistry, 2000, Dimmock, Jonathan R et. al.
Evaluation of “norpeptides” as potential inhibitors of HIV-proteases
score: 0.43336591, Bioorganic & Medicinal Chemistry, 1994, Burgess, Kevin; Pal, Biman
Enhancing effects of α-, β-monoglycosylceramides on natural killer cell activity
score: 0.43330484, Bioorganic & Medicinal Chemistry, 1996, Kobayashi, Eiichi et. al.
HIV-1 protease inhibitors: Ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs
score: 0.43314489, Bioorganic & Medicinal Chemistry, 1994, Marinier, Aime et. al.
X-Neu5Ac: A novel substrate for chromogenic assay of neuraminidase activity in bacterial expression systems
score: 0.43307934, Bioorganic & Medicinal Chemistry, 1993, Fujii, Ikuo et. al.
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.
score: 0.43272489, Nature chemical biology, 2012, Saulière, Aude et. al.
The Discovery of the CCR5 Receptor Antagonist, UK-427,857, A New Agent for the Treatment of HIV Infection and AIDS
score: 0.43165703, Progress in Medicinal Chemistry, 2005, Wood, Anthony; Armour, Duncan
Peptide Nucleic Acids (PNA): Synthesis, properties and potential applications
score: 0.43161605, Bioorganic & Medicinal Chemistry, 1996, Hyrup, Birgitte; Nielsen, Peter E.
d- myo-Inositol 1,4,5-trisphosphate analogues as useful tools in biochemical studies of intracellular calcium mobilization
score: 0.43157542, Bioorganic & Medicinal Chemistry, 1994, Gou, Da-Ming; Shieh, Woan-Ru; Lu, Pei-Jung; Chen, Ching-Shih
Teaching the design principles of metabolism.
score: 0.43142183, Nature chemical biology, 2012, Rabinowitz, Joshua D; Vastag, Livia
RNA at santa cruz.
score: 0.43127371, Nature chemical biology, 2007, Bucci, Mirella
Design and synthesis of 1,5- and 2,5-substituted tetrahydrobenzazepinones as novel potent and selective integrin α Vβ 3 antagonists
score: 0.43108865, Bioorganic & Medicinal Chemistry, 2003, Kling, Andreas et. al.
Cytochrome bd confers nitric oxide resistance to Escherichia coli.
score: 0.43060511, Nature chemical biology, 2009, Mason, Maria G et. al.
Manipulating proteostasis.
score: 0.43039896, Nature chemical biology, 2010, Sifers, Richard N
PEGylated PPI dendritic architectures for sustained delivery of H 2 receptor antagonist
score: 0.43032441, European Journal of Medicinal Chemistry, 2009, Gajbhiye, Virendra et. al.
Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition.
score: 0.4303003, Molecular pharmacology, 2010, Kirpotina, Liliya N et. al.
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues.
score: 0.43009784, Nature chemical biology, 2005, Bryan, Nathan S et. al.
Transforming fragments into candidates: small becomes big in medicinal chemistry
score: 0.42929165, Drug Discovery Today, 2009, de Kloe, Gerdien E. et. al.
Understanding human rhinovirus infections in terms of QSAR
score: 0.42925008, Virology, 2007, Verma, Rajeshwar P.; Hansch, Corwin
Identifying Tumor Cell Growth Inhibitors by Combinatorial Chemistry and Zebrafish Assays
score: 0.42912621, PLoS ONE, 2009, Xiang, Jing et. al.
N-glycan structure dictates extension of protein folding or onset of disposal.
score: 0.42909848, Nature chemical biology, 2007, Molinari, Maurizio
Plasma stability and cytotoxicity of lipophilic daunorubicin derivatives incorporated into low density lipoproteins
score: 0.42896387, European Journal of Medicinal Chemistry, 2000, Masquelier, Michèle et. al.
The conformation and activity relationship of fused analogs of DuP753
score: 0.4286139, Bioorganic & Medicinal Chemistry, 1995, Yoo, Sung-eun; Shin, Young Ah; Lee, Sung-Hou; Kim, Nak-Jung
Engineering sulfotransferases to modify heparan sulfate.
score: 0.42846445, Nature chemical biology, 2008, Xu, Ding et. al.
Thyrsiferyl 23-acetate and its derivatives induce apoptosis in various T- and B-leukemia cells
score: 0.42826161, Bioorganic & Medicinal Chemistry, 1999, Matsuzawa, Shu-ichi et. al.
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.
score: 0.42760774, Proceedings of the National Academy of Sciences of the United States of America, 2011, Huryn, Donna M et. al.
Coming clean.
score: 0.42710065, Nature chemical biology, 2005,
Enzymatic glycosynthesis GeTs better.
score: 0.42701206, Nature chemical biology, 2007, Davis, Benjamin G
Alkaloid biosynthesis takes root.
score: 0.42670111, Nature chemical biology, 2009, Ryan, Katherine S; Moore, Bradley S
A CoMFA study of COX-2 inhibitors with receptor based alignment
score: 0.4260726, Journal of Molecular Graphics and Modelling, 2004, Datar, Prasanna A.; Coutinho, Evans C.
Chemistry of polyhalogenated nitrobutadienes, 8: Nitropolychlorobutadienes—Precursors for insecticidal neonicotinoids
score: 0.42587438, Bioorganic & Medicinal Chemistry, 2009, Zapol’skii, Viktor A. et. al.
Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents
score: 0.42566178, Bioorganic & Medicinal Chemistry, 1995, Gordaliza, Marina et. al.
Synthesis and neuromuscular blocking activity of 16β-piperidinosteroidal derivatives
score: 0.42540402, European Journal of Medicinal Chemistry, 2001, Jindal, Dharam Paul et. al.
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis
score: 0.42447605, Nature chemical biology, 2009, Schmelz, Stefan et. al.
Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds
score: 0.424327, European Journal of Medicinal Chemistry, 2000, Dimmock, Jonathan R; Vashishtha, Sarvesh C; Stables, James P
Pamela Silver.
score: 0.42423507, Nature chemical biology, 2007, Goodman, Catherine
A sugar-coated switch for cellular growth and arrest.
score: 0.42377722, Nature chemical biology, 2007, Taniguchi, Naoyuki
Synthesis and in vivo biodistribution of F-18 labeled 3- cis-, 3- trans-, 4- cis-, and 4- trans-fluorocyclohexane derivatives of WAY 100635
score: 0.42375203, Bioorganic & Medicinal Chemistry, 2006, Lang, Lixin et. al.
Foundation funding and chemical biology.
score: 0.42344067, Nature chemical biology, 2008, McGovern, Victoria
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.
score: 0.42264737, Nature chemical biology, 2011, Small, Ben G et. al.
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
score: 0.42253056, Nature chemical biology, 2008, Gold, Ben et. al.
Small molecules not direct activators of caspases.
score: 0.42236795, Nature chemical biology, 2007, Denault, Jean-Bernard et. al.
Synthetic carbohydrate vaccines: Synthesis and immunogenicity of Tn antigen conjugates
score: 0.42227382, Bioorganic & Medicinal Chemistry, 1994, Toyokuni, Tatsushi; Hakomori, Sen-itiroh; Singhal, Anil K.
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.
score: 0.42200485, Nature chemical biology, 2011, Gloster, Tracey M et. al.
In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz.
score: 0.42190779, Nature chemical biology, 2010, Woodward, Robert et. al.
From yeast to alkaloids.
score: 0.42155076, Nature chemical biology, 2008, Keasling, Jay
Effects of squalene epoxidase inhibitors on Candida albicans.
score: 0.42143619, Antimicrobial agents and chemotherapy, 1992, Georgopapadakou, N H; Bertasso, A
6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus.
score: 0.42143288, Antimicrobial agents and chemotherapy, 1991, Averett, D R et. al.
Discovery of small molecule cancer drugs: Successes, challenges and opportunities
score: 0.4211603, Molecular Oncology, 2012, Hoelder, Swen; Clarke, Paul A.; Workman, Paul
Discovery of small molecule cancer drugs: Successes, challenges and opportunities
score: 0.4211603, Molecular Oncology, 2012, Hoelder, Swen; Clarke, Paul A.; Workman, Paul
Taking the chemical out of chemical genetics.
score: 0.42092224, Nature chemical biology, 2009, Scott, Charles P
Visualization of enzyme-catalyzed reactions using pH indicators: rapid screening of hydrolase libraries and estimation of the enantioselectivity
score: 0.42062426, Bioorganic & Medicinal Chemistry, 1999, Morı́s-Varas, Francisco et. al.
Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase
score: 0.42039521, Bioorganic & Medicinal Chemistry, 2006, Decker, Michael; Krauth, Fabian; Lehmann, Jochen
How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels.
score: 0.4203907, Nature chemical biology, 2012, Kusch, Jana et. al.
Structural requirements of the N-terminal region of GLP-1-[7-37]-NH 2 for receptor interaction and cAMP production
score: 0.42023699, European Journal of Medicinal Chemistry, 2004, Sarrauste de Menthière, Cyril et. al.
Structural landscape of isolated agonist-binding domains from single AMPA receptors.
score: 0.42016476, Nature chemical biology, 2011, Landes, Christy F et. al.
The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
score: 0.42004973, Nature chemical biology, 2010, Berndt, Alex et. al.
The influence of drug-like concepts on decision-making in medicinal chemistry.
score: 0.41949091, Nature reviews. Drug discovery, 2007, Leeson, Paul D; Springthorpe, Brian
An in vitro investigation into conformational aspects of gabapentin
score: 0.41928354, Bioorganic & Medicinal Chemistry, 1999, Bryans, Justin S. et. al.
Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins
score: 0.41878685, Antiviral Research, 2006, Baleja, James D. et. al.
BCR-ABL signaling: A new STATus in CML.
score: 0.41856693, Nature chemical biology, 2012, Fabbro, Doriano
Signaling: retromer arrests receptor on the run.
score: 0.41810808, Nature chemical biology, 2011, van Weering, Jan R T; Cullen, Peter J
Design of fructose-2,6-bisphosphatase inhibitors: A novel virtual screening approach
score: 0.4180576, Journal of Molecular Graphics and Modelling, 2008, Shaikh, M.S.; Mittal, Amit; Bharatam, P.V.
The rule of four.
score: 0.41783518, Nature chemical biology, 2007, Armitage, Bruce A
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity
score: 0.41760729, Journal of Biomedical Science, 2010, Shih, Shin-Ru et. al.
EPC syntheses and structure–activity relationships of hypoglycaemic semicyclic amidines
score: 0.41755742, European Journal of Medicinal Chemistry, 2000, Hartmann, Susanne et. al.
Functional, synthetic organic chemical models of cellular ion channels
score: 0.41733368, Bioorganic & Medicinal Chemistry, 2004, Gokel, George W et. al.
The devil (and an active jasmonate hormone) is in the details.
score: 0.41729176, Nature chemical biology, 2009, Yi, Hankuil; Preuss, Mary L; Jez, Joseph M
Timing facilitated site transfer of an enzyme on DNA.
score: 0.41725503, Nature chemical biology, 2012, Schonhoft, Joseph D; Stivers, James T
Quantitative structure-activity relationships for PPAR-gamma binding and gene transactivation of tyrosine-based agonists using multivariate statistics.
score: 0.41691269, Chemical biology & drug design, 2008, Giaginis, Costas et. al.
Docking and scoring in virtual screening for drug discovery: methods and applications.
score: 0.41687081, Nature reviews. Drug discovery, 2004, Kitchen, Douglas B et. al.
Made to measure.
score: 0.41647969, Nature chemical biology, 2011,
Chemical decay of an antibiotic inverts selection for resistance.
score: 0.41647969, Nature chemical biology, 2010, Palmer, Adam C; Angelino, Elaine; Kishony, Roy
Going global?
score: 0.41647969, Nature chemical biology, 2006,
The biology of time across different scales.
score: 0.41647969, Nature chemical biology, 2007, Buonomano, Dean V
Huntington's disease: flipping a switch on huntingtin.
score: 0.41647969, Nature chemical biology, 2011, Greiner, Erin R; Yang, X William
Chemical biology makes an impact.
score: 0.41647969, Nature chemical biology, 2007,
Per2 has time on its side.
score: 0.41647969, Nature chemical biology, 2007, Albrecht, Urs
Retromer terminates the generation of cAMP by internalized PTH-receptors
score: 0.41632501, Nature chemical biology, 2011, Feinstein, Timothy N. et. al.
A decade of fragment-based drug design: strategic advances and lessons learned.
score: 0.41618328, Nature reviews. Drug discovery, 2007, Hajduk, Philip J; Greer, Jonathan
Imidazo[1,2- a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity
score: 0.41593279, European Journal of Medicinal Chemistry, 2001, Parra, Stéphanie et. al.
Translation of the phosphoinositide code by PI effectors.
score: 0.41564289, Nature chemical biology, 2010, Kutateladze, Tatiana G
Remarkable structural variation within fatty acid megasynthases.
score: 0.41554513, Nature chemical biology, 2006, Cronan, John E
Targeting proteins for degradation.
score: 0.41512563, Nature chemical biology, 2009, Schrader, Erin K; Harstad, Kristine G; Matouschek, Andreas
Synthesis and pharmacological study of ethyl 1-methyl-5-(substituted 3,4-dihydro-4-oxoquinazolin-3-yl)-1 H-pyrazole-4-acetates
score: 0.41433388, European Journal of Medicinal Chemistry, 2001, Maggio, Benedetta et. al.
Conformational analysis of the endogenous μ-opioid agonist endomorphin-1 using NMR spectroscopy and molecular modeling
score: 0.41428105, FEBS Letters, 1998, Podlogar, Brent L. et. al.
Synthesis and screening of novel vitamin E derivatives for anticancer functions
score: 0.41366366, European Journal of Medicinal Chemistry, 2012, Chen, Wenbin et. al.
A stereocontrolled synthetic approach to glycopeptides corresponding to the carbohydrate-protein linkage region of cell-surface proteoglycans
score: 0.41364354, Bioorganic & Medicinal Chemistry, 1995, Neumann, Klaus W.; Tamura, Jun-ichi; Ogawa, Tomoya
Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects
score: 0.41357783, Bioorganic & Medicinal Chemistry, 2004, Račková, Lucia et. al.
Design, docking, and evaluation of multiple libraries against multiple targets.
score: 0.41300005, Proteins, 2001, Lamb, M L et. al.
Deciphering a protolanguage for bacteria-host communication.
score: 0.41265318, Nature chemical biology, 2008, Palmer, Andrew G; Blackwell, Helen E
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
score: 0.41241064, Nature chemical biology, 2010, Li, Jiannong et. al.
The selective quantification of iron by hexadentate fluorescent probes
score: 0.41205652, Bioorganic & Medicinal Chemistry, 2009, Ma, Yong Min; Hider, Robert C.
The Discovery of the CCR5 Receptor Antagonist, UK-427,857, A New Agent for the Treatment of HIV Infection and AIDS
score: 0.41190205, Progress in Medicinal Chemistry, 2005, Wood, Anthony; Armour, Duncan
Kinetic flux profiling of nitrogen assimilation in Escherichia coli.
score: 0.41147381, Nature chemical biology, 2006, Yuan, Jie et. al.
Synthetic sugars enhance the functional glycomics toolkit.
score: 0.41084637, Nature chemical biology, 2006, Turnbull, Jeremy E; Linhardt, Robert J
Determining the occurrence of a 3 10-helix and an α-helix in two different segments of a lipopeptaibol antibiotic using TOAC, a nitroxide spin-labeled C α-tetrasubstituted α-aminoacid
score: 0.41034516, Bioorganic & Medicinal Chemistry, 1999, Monaco, Vania et. al.
Sequence specific recognition of ssDNA by a lupus autoantibody
score: 0.41010323, Bioorganic & Medicinal Chemistry, 2001, Beckingham, Jennifer A.; Glick, Gary D.
From students to scientists at XLAB.
score: 0.41001986, Nature chemical biology, 2009, Goodman, Catherine
DNA replication: changing faces, trading places.
score: 0.40976091, Nature chemical biology, 2010, Campbell, Judith L
New mechanism for a classic folate inhibitor.
score: 0.40943237, Nature chemical biology, 2008, Brown, H Alex
An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids
score: 0.40923287, Nature chemical biology, 2009, Brudno, Yevgeny et. al.
Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates
score: 0.40905303, Bioorganic & Medicinal Chemistry, 1994, Yli-Kauhaluoma, Jari; Janda, Kim D.
Biotin synthesis begins by hijacking the fatty acid synthetic pathway.
score: 0.4083671, Nature chemical biology, 2010, Lin, Steven; Hanson, Ryan E; Cronan, John E
Structural basis for RNA trimming by RNase T in stable RNA 3'-end maturation.
score: 0.40830945, Nature chemical biology, 2011, Hsiao, Yu-Yuan et. al.
Iron-sulfur clusters: ever-expanding roles.
score: 0.40819664, Nature chemical biology, 2006, Fontecave, Marc
Networking at the Protein Society symposium.
score: 0.40805041, Nature chemical biology, 2005, McKnight, C James; Cordes, Matthew H J
Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction.
score: 0.40782705, Nature chemical biology, 2011, Fierz, Beat et. al.
Conserved mechanisms regulate outgrowth in zebrafish fins.
score: 0.40724241, Nature chemical biology, 2007, Iovine, M Kathryn
An aminotransferase branch point connects purine catabolism to amino acid recycling.
score: 0.40664429, Nature chemical biology, 2010, Ramazzina, Ileana et. al.
Sustainable Sciences Institute.
score: 0.40648289, Nature chemical biology, 2007, Kotz, Joanne
Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors
score: 0.40614099, Bioorganic & Medicinal Chemistry, 2012, Poongavanam, Vasanthanathan et. al.
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.
score: 0.40601856, Nature chemical biology, 2011, Verrier, Florence et. al.
Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin
score: 0.40557788, Viruses, 2013, Yang, Jie; Li, Minmin; Shen, Xintian; Liu, Shuwen
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.
score: 0.40544316, Nature chemical biology, 2005, Lautru, Sylvie et. al.
General synthesis and biological evaluation of α-1- C-substituted derivatives of fagomine (2-deoxynojirimycin-α- C-glycosides)
score: 0.40525374, Bioorganic & Medicinal Chemistry, 2005, Goujon, Jean-Yves et. al.
Amino acids that specify structure through hydrophobic clustering and histidine-aromatic interactions lead to biologically active peptidomimetics
score: 0.40515513, Bioorganic & Medicinal Chemistry, 1994, Graciani, Nilsa R. et. al.
Differences in prion strain conformations result from non-native interactions in a nucleus.
score: 0.40496679, Nature chemical biology, 2010, Ohhashi, Yumiko et. al.
It's a mod mod tRNA world.
score: 0.40456501, Nature chemical biology, 2008, Maraia, Richard J; Blewett, Nathan H; Bayfield, Mark A
The influence of the 'organizational factor' on compound quality in drug discovery.
score: 0.40426231, Nature reviews. Drug discovery, 2011, Leeson, Paul D; St-Gallay, Stephen A
Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock
score: 0.40396959, Journal of Cheminformatics, 2009, Bikadi, Zsolt; Hazai, Eszter
High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors
score: 0.40396432, PLoS Pathogens, 2009, Christophe, Thierry et. al.
This time.
score: 0.40341303, Nature chemical biology, 2009,
A fast and inexpensive method for N-terminal fluorescein-labeling of peptides
score: 0.40325669, Bioorganic & Medicinal Chemistry Letters, 1998, Weber, Peter J.A et. al.
Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis.
score: 0.40320018, Nature chemical biology, 2010, Chen, Junjun et. al.
Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study
score: 0.40151768, Bioorganic & Medicinal Chemistry, 1995, Groutas, William C. et. al.
An octakis-intercalating molecule
score: 0.40135118, Bioorganic & Medicinal Chemistry, 2001, Murr, Meredith M et. al.
Polymerization of mannosyl tricyclic orthoesters for the synthesis of α(1–6) mannopyranan—the backbone of lipomannan
score: 0.40095761, Bioorganic & Medicinal Chemistry, 2010, Yongyat, Chanokpon et. al.
Receptors: GPCR-G protein preassembly?
score: 0.40043588, Nature chemical biology, 2011, Challiss, R A John; Wess, Jürgen
Structural Determinants of CX-4945 Derivatives as Protein Kinase CK2 Inhibitors: A Computational Study
score: 0.39991648, International Journal of Molecular Sciences, 2011, Liu, Hongbo et. al.
Do-it-yourself enzymes.
score: 0.3992447, Nature chemical biology, 2008, Nanda, Vikas
Assembling iron-sulfur clusters in the cytosol.
score: 0.39897996, Nature chemical biology, 2007, Broderick, Joan B
Rethinking glycolysis: on the biochemical logic of metabolic pathways.
score: 0.39844739, Nature chemical biology, 2012, Bar-Even, Arren; Flamholz, Avi; Noor, Elad; Milo, Ron
Synthesis of Benzodioxinopyrroles as selective α 2-adrenoceptor antagonists
score: 0.39822668, Bioorganic & Medicinal Chemistry, 1995, Kitchin, J. et. al.
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
score: 0.39808468, Nature chemical biology, 2012, Puri, Aaron W. et. al.
Protein misfolding: Tracking a toxic polyQ epitope.
score: 0.39803479, Nature chemical biology, 2011, Tanaka, Motomasa
Natural expansion of the genetic code.
score: 0.39795227, Nature chemical biology, 2007, Ambrogelly, Alexandre; Palioura, Sotiria; Söll, Dieter
The proteoglycan bikunin has a defined sequence
score: 0.39737083, Nature Chemical Biology, 2011, Ly, Mellisa et. al.
Encoding synthetic polymers.
score: 0.39724836, Nature chemical biology, 2008, van Hest, Jan C M
Monell chemical senses center.
score: 0.3968518, Nature chemical biology, 2009, Goodman, Catherine
Protein dynamics: bridging the gap.
score: 0.39679122, Nature chemical biology, 2011, Daughdrill, Gary W
Synthesis of new pyrazolyl-2, 4-thiazolidinediones as antibacterial and antifungal agents
score: 0.39577804, Organic and Medicinal Chemistry Letters, 2011, Aneja, Deepak K et. al.
Structure-based discovery of antibacterial drugs.
score: 0.39555312, Nature reviews. Microbiology, 2010, Simmons, Katie J; Chopra, Ian; Fishwick, Colin W G
Chemical decay of an antibiotic inverts selection for resistance
score: 0.39474394, Nature chemical biology, 2010, Palmer, Adam C.; Angelino, Elaine; Kishony, Roy
Raging hormones in plants.
score: 0.39429, Nature chemical biology, 2008, Pichersky, Eran
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.
score: 0.39391451, Nature chemical biology, 2009, Schmelz, Stefan et. al.
Translating metabolic exchange with imaging mass spectrometry.
score: 0.39381027, Nature chemical biology, 2009, Yang, Yu-Liang et. al.
A new path to auxin.
score: 0.39349941, Nature chemical biology, 2008, Strader, Lucia C; Bartel, Bonnie
Biomaterials: metabolites empowering minerals.
score: 0.39322036, Nature chemical biology, 2011, Weiss, Ingrid M
Pyrrolo[3,2- d ]pyrimidine Derivatives as Type II Kinase Insert Domain Receptor (KDR) Inhibitors: CoMFA and CoMSIA Studies
score: 0.39213235, International Journal of Molecular Sciences, 2012, Wu, Xiao-Yun et. al.
Structure-based design of nitrosoureas containing tyrosine derivatives as potential antimelanoma agents
score: 0.39206384, European Journal of Medicinal Chemistry, 2002, Gadjeva, Vesselina
Getting the iron out.
score: 0.39185829, Nature chemical biology, 2005, Barry, Clifton E; Boshoff, Helena
The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine.
score: 0.39182528, Nature chemical biology, 2011, Roy, Hervé et. al.
20S ways to apoptosis.
score: 0.39168802, Nature chemical biology, 2008, McConkey, David J
The interdependence between screening methods and screening libraries
score: 0.39125265, Current Opinion in Chemical Biology, 2007, Shelat, Anang A; Guy, R Kiplin
Actions of cyclic esters, S-esters, and amides of phenyl- and phenylthiophosphonic acids on mammalian and insect GABA-gated chloride channels
score: 0.39109705, Bioorganic & Medicinal Chemistry, 1998, Ozoe, Yoshihisa et. al.
Discovery of protease inhibitors using targeted libraries
score: 0.39095073, Current Opinion in Chemical Biology, 1998, Whittaker, Mark
Inhibitors of the kynurenine pathway
score: 0.39015519, European Journal of Medicinal Chemistry, 2000, Stone, Trevor W
Sweet insights into learning and memory.
score: 0.38975625, Nature chemical biology, 2006, Hart, Gerald W
‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries
score: 0.38966739, Drug Discovery Today, 2009, Dobson, Paul D.; Patel, Yogendra; Kell, Douglas B.
Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration
score: 0.38904885, European Journal of Medicinal Chemistry, 2000, Colombo, Diego et. al.
The role of iron regulatory proteins in mammalian iron homeostasis and disease.
score: 0.3885845, Nature chemical biology, 2006, Rouault, Tracey A
Synthesis and antitubercular activity of imidazo[2,1- b]thiazoles
score: 0.38835819, European Journal of Medicinal Chemistry, 2001, Andreani, Aldo et. al.
Infectious diseases: Transporter targeted in tuberculosis.
score: 0.38811702, Nature chemical biology, 2012, Cole, Stewart T
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.
score: 0.3880774, Antimicrobial agents and chemotherapy, 1994, Schinazi, R F et. al.
In vitro reconstruction of tetronate RK-682 biosynthesis.
score: 0.38793032, Nature chemical biology, 2010, Sun, Yuhui et. al.
A new synthetic protocol for labeled oligonucleotides, using a chemically cleavable universal linker
score: 0.3876966, Bioorganic & Medicinal Chemistry, 2006, Mahajan, Shweta et. al.
Stochastic kinetics of intracellular huntingtin aggregate formation.
score: 0.38750571, Nature chemical biology, 2006, Colby, David W et. al.
Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate.
score: 0.38714214, Nature chemical biology, 2011, Maeda, Hiroshi; Yoo, Heejin; Dudareva, Natalia
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins
score: 0.38685803, Nature chemical biology, 2010, Hoffstrom, Benjamin G. et. al.
Switching modes for G protein-coupled receptor activation.
score: 0.38659965, Nature chemical biology, 2006, Vilardaga, Jean-Pierre
Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): An effective inhibitor of glycinamide ribonucleotide transformylase
score: 0.38599097, Bioorganic & Medicinal Chemistry, 1997, Boger, Dale L. et. al.
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation.
score: 0.38593017, Nature chemical biology, 2006, Margolin, Yelena et. al.
In silico screening of quadruplex-binding ligands
score: 0.38582631, Methods, 2012, Ma, Dik-Lung et. al.
In silico screening of quadruplex-binding ligands
score: 0.38582631, Methods, 2012, Ma, Dik-Lung et. al.
Antiproliferative actions of 7-substituted 1,3-dihydroxyacridones; possible involvement of DNA topoisomerase II and protein kinase C as biochemical targets
score: 0.38522878, Bioorganic & Medicinal Chemistry, 1994, Bastow, Kenneth F. et. al.
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
score: 0.38452882, Nature chemical biology, 2010, Guo, Zhigang et. al.
Combinatorial biosynthesis in symbiotic bacteria.
score: 0.38448631, Nature chemical biology, 2006, Piel, Jörn
Functional derivatives of 5-benzo[1,3]dioxol-5-yl-1-methyl- 1H -imidazole-2-carbaldehyde and evaluation of leishmanicidal activity
score: 0.3841949, European Journal of Medicinal Chemistry, 2000, Vanelle, Patrice et. al.
Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[ 11C]methyl-2-( S)-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomography
score: 0.38419352, Bioorganic & Medicinal Chemistry, 2001, Brown, LaVerne L. et. al.
Copper shares a piece of the pi.
score: 0.38414878, Nature chemical biology, 2008, Franz, Katherine J
Post-translational modifications: S-linked sugars lost and found.
score: 0.3833999, Nature chemical biology, 2011, Sardzík, Róbert; Both, Peter; Flitsch, Sabine L
Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae
score: 0.38335499, Biochemical Pharmacology, 2010, Salin, Olli et. al.
Hypoxia sensing goes gauche.
score: 0.38286774, Nature chemical biology, 2009, Fujimori, Danica Galonić
Synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors of steroid-5α-reductase type 1 and 2
score: 0.38208752, Bioorganic & Medicinal Chemistry, 2000, Picard, Franck et. al.
Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase
score: 0.38201636, Nature chemical biology, 2012, Xu, Yi-Fan et. al.
Structural modelling and dynamics of proteins for insights into drug interactions
score: 0.38199629, Advanced Drug Delivery Reviews, 2012, Werner, Tim et. al.
MS-271, A novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp.—II. Solution structure of MS-271: Characteristic features of the ‘lasso’ structure
score: 0.3819322, Bioorganic & Medicinal Chemistry, 1996, Katahira, Ritsuko et. al.
Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins
score: 0.38187164, Nature chemical biology, 2011, Neklesa, Taavi K. et. al.
CH/π interactions in the crystal structure of class I MHC antigens and their complexes with peptides
score: 0.38186828, Bioorganic & Medicinal Chemistry, 1998, Umezawa, Yoji; Nishio, Motohiro
An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties and In Vivo Efficacy.
score: 0.38186511, Antimicrobial agents and chemotherapy, 2012, Stokes, Neil R et. al.
Scientists without borders.
score: 0.38176722, Nature chemical biology, 2008, Kotz, Joanne
Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation
score: 0.38144675, Nature chemical biology, 2009, Han, Yang et. al.
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
score: 0.38143034, Nature chemical biology, 2012, Zhang, Liang et. al.
Programming cellular function.
score: 0.38088752, Nature chemical biology, 2005, Voigt, Christopher A; Keasling, Jay D
Discovery of a natural thiamine adenine nucleotide.
score: 0.38080232, Nature chemical biology, 2007, Bettendorff, Lucien et. al.
AutoClickChem: Click Chemistry in Silico
score: 0.3807329, PLoS Computational Biology, 2012, Durrant, Jacob D.; McCammon, J. Andrew
Cathepsin K Inhibitors: Their Potential as Anti-Osteoporosis Agents
score: 0.38058759, Progress in Medicinal Chemistry, 2004, Deaton, David N.; Kumar, Sanjay
Design, Synthesis and Characterization of a Highly Effective Inhibitor for A nalog- S ensitive ( as ) Kinases
score: 0.38047733, PLoS ONE, 2011, Klein, Michael et. al.
Plant chemical biology: Florigen takes two to tango.
score: 0.38033051, Nature chemical biology, 2011, Mylne, Joshua S; Wigge, Philip A
Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY.
score: 0.38016556, Nature chemical biology, 2008, Livingston, Alison L et. al.
Benzodiazepine peptidomimetic inhibitors of farnesyltransferase
score: 0.37959562, Bioorganic & Medicinal Chemistry, 1994, Marsters, James C. et. al.
DNA revisited.
score: 0.37901109, Nature chemical biology, 2008, Lilley, David M J
Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags.
score: 0.37780337, Nature chemical biology, 2010, Rexach, Jessica E et. al.
Novel doxorubicin-monoclonal anti-carcinoembryonic antigen antibody immunoconjugate activity in vitro
score: 0.37763566, Bioorganic & Medicinal Chemistry, 1995, Lau, Achilles et. al.
Chemical cues for sea lamprey migration.
score: 0.37755875, Nature chemical biology, 2005, Dittman, Andrew
Screening: Low-fat worms on drugs.
score: 0.3773335, Nature chemical biology, 2011, Wagner, Bridget K
Testosterone delivery using glutamide-based complex high axial ratio microstructures
score: 0.37674848, Bioorganic & Medicinal Chemistry, 2001, Goldstein, Alex S et. al.
Keynote review: Structural biology and drug discovery
score: 0.3765432, Drug Discovery Today, 2005, Congreve, Miles; Murray, Christopher W.; Blundell, Tom L.
Discovery of new β-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.
score: 0.37647813, Journal of computational chemistry, 2011, Abdula, Ahmed Mutanabbi et. al.
Ion channels: Manipulating the munchies in mice.
score: 0.37572041, Nature chemical biology, 2011, Akabas, Myles H
Identification, synthesis and pharmacological activity of moxonidine metabolites
score: 0.37496737, European Journal of Medicinal Chemistry, 2002, Wirth, David D et. al.
A gateway to study protein lysine methylation.
score: 0.37493033, Nature chemical biology, 2008, Trojer, Patrick; Reinberg, Danny
QSAR analysis and molecular modeling of ABCG2-specific inhibitors
score: 0.37390045, Advanced Drug Delivery Reviews, 2009, Nicolle, E. et. al.
QSAR analysis and molecular modeling of ABCG2-specific inhibitors
score: 0.37390045, Advanced Drug Delivery Reviews, 2009, Nicolle, E. et. al.
Linking physiological functions of iron.
score: 0.37353634, Nature chemical biology, 2005, Rouault, Tracey A
Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323.
score: 0.37299394, Antimicrobial agents and chemotherapy, 1994, Erickson-Viitanen, S et. al.
Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase.
score: 0.37290345, Antimicrobial agents and chemotherapy, 1994, Gootz, T D; McGuirk, P R; Moynihan, M S; Haskell, S L
Chromatin: a ubiquitin crowbar opens chromatin.
score: 0.37288255, Nature chemical biology, 2011, Peterson, Craig L
Stereochemical Control of Peptide Folding
score: 0.37281655, Bioorganic & Medicinal Chemistry, 1999, Kaul, Ramesh; Balaram, P
Breaking the silence in Friedreich's ataxia.
score: 0.37174174, Nature chemical biology, 2006, Festenstein, Richard
Phenotypic screening: Fishing for neuroactive compounds.
score: 0.37172733, Nature chemical biology, 2010, Jenkins, Jeremy L; Urban, Laszlo
Right on cue.
score: 0.37172492, Nature chemical biology, 2006, Lauffenburger, Douglas A
Cathepsin K Inhibitors: Their Potential as Anti-Osteoporosis Agents
score: 0.37151194, Progress in Medicinal Chemistry, 2004, Deaton, David N.; Kumar, Sanjay
Chemical synthesis of 15-ketosterols and their inhibitions of cholesteryl ester transfer protein
score: 0.37078968, Bioorganic & Medicinal Chemistry, 1995, Kim, Hong-Seok et. al.
Lactate transportation is required for lymphocyte activation.
score: 0.37060399, Nature chemical biology, 2005, Bröer, Stefan
Synthesis and in vitro cytotoxic activity of pyrrolo[2,3-e]indole derivatives and a dihydro benzoindole analogue
score: 0.37049808, European Journal of Medicinal Chemistry, 2002, Chacón-Garcı́a, Luis; Martı́nez, Roberto
Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.
score: 0.36993313, Nature chemical biology, 2008, Meloni, Gabriele et. al.
Methuselah antagonist extends life span.
score: 0.36947162, Nature chemical biology, 2007, McGarrigle, Deirdre; Huang, Xin-Yun
Non-covalent interactions: Fold globally, bond locally.
score: 0.36925064, Nature chemical biology, 2010, Zondlo, Neal J
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence.
score: 0.36887727, Nature chemical biology, 2010, Gerlach, Holger et. al.
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding.
score: 0.36839063, Nature chemical biology, 2010, Guo, Zhigang et. al.
Rational design of Tamiflu derivatives targeting at the open conformation of neuraminidase subtype 1
score: 0.36753301, Journal of Molecular Graphics and Modelling, 2009, Li, Yan; Zhou, Bingcheng; Wang, Renxiao
The Reactivity of well defined diiron(III) peroxo complexes toward substrates: addition to electrophiles and hydrocarbon oxidation
score: 0.36746897, Bioorganic & Medicinal Chemistry, 1999, LeCloux, Daniel D.; Barrios, Amy M.; Lippard, Stephen J.
Insights into signaling from the beta2-adrenergic receptor structure.
score: 0.36746718, Nature chemical biology, 2008, Audet, Martin; Bouvier, Michel
A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility.
score: 0.36716465, Nature chemical biology, 2005, Fleming, Craig et. al.
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile
score: 0.36705046, Purinergic Signalling, 2006, Cacciari, Barbara et. al.
Synthesis and anti-inflammatory activity of 1-acetyl-5-substitute daryl-3-(β-aminonaphthyl)-2-pyrazolines and β-(substitute daminoethyl) amidonaphthalenes
score: 0.3660704, European Journal of Medicinal Chemistry, 2001, Bansal, Ekta; Srivastava, V.K; Kumar, Ashok
Synthesis of di- to penta-saccharides related to the O-specific polysaccharide of Shigella dysenteriae type 1, and their nuclear magnetic resonance study
score: 0.36596651, Bioorganic & Medicinal Chemistry, 1993, Pozsgay, Vince; Coxon, Bruce; Yeh, Herman
Investigation of potential glycogen synthase kinase 3 inhibitors using pharmacophore mapping and virtual screening.
score: 0.36595881, Chemical biology & drug design, 2006, Dessalew, Nigus; Bharatam, Prasad V
Synthesis and structure–activity relationships of novel arylalkyl 4-benzyl piperazine derivatives as σ site selective ligands
score: 0.36577577, European Journal of Medicinal Chemistry, 2000, Younes, Salomé et. al.
Defining the geometry of the two-component proteasome degron
score: 0.36546602, Nature chemical biology, 2011, Inobe, Tomonao et. al.
Synthesis of N-acetylglucosaminyl asparagine-substituted puromycin analogues
score: 0.36536813, Bioorganic & Medicinal Chemistry, 1995, Kirsch, Peer et. al.
Short-circuiting RNA splicing.
score: 0.3646425, Nature chemical biology, 2008, Disney, Matthew D
10-Phenylbutyryl-substituted anthracenones as inhibitors of keratinocyte growth and LTB 4 biosynthesis
score: 0.36412292, European Journal of Medicinal Chemistry, 2001, Müller, Klaus; Breu, Klaus; Reindl, Hans
Social engineering for virtual 'big science' in systems biology.
score: 0.36388401, Nature chemical biology, 2011, Kitano, Hiroaki; Ghosh, Samik; Matsuoka, Yukiko
Synthesis of steroid intermediates via alkylation of dianion derived from acetoacetic ester
score: 0.36373332, Bioorganic & Medicinal Chemistry, 1994, Wang, K.C. et. al.
Sensing cellular magnesium with RNA.
score: 0.36335859, Nature chemical biology, 2007, DeRose, Victoria J
Therapeutic treasures from the deep.
score: 0.36327278, Nature chemical biology, 2007, Hopwood, David A
BCL-2 family antagonists for cancer therapy.
score: 0.36323477, Nature reviews. Drug discovery, 2008, Lessene, Guillaume; Czabotar, Peter E; Colman, Peter M
AMP-activated protein kinase: nature's energy sensor.
score: 0.36302501, Nature chemical biology, 2011, Carling, David et. al.
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
score: 0.36269325, Nature chemical biology, 2012, Zhang, Liang et. al.
Synthesis and in vitro binding of N, N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites
score: 0.36221954, Bioorganic & Medicinal Chemistry, 2006, Homes, Taryn P. et. al.
Drug discovery: engineering drug combinations.
score: 0.36201448, Nature chemical biology, 2010, Dixon, Scott J; Stockwell, Brent R
Oxidation of oxa and thia fatty acids and related compounds catalysed by 5- and 15-lipoxygenase
score: 0.36190991, Bioorganic & Medicinal Chemistry, 2001, Easton, Christopher J. et. al.
The yeast Wsc1 cell surface sensor behaves like a nanospring in vivo.
score: 0.36130624, Nature chemical biology, 2009, Dupres, Vincent et. al.
Unexpected N-terminal editing: a cysteine protease that cuts and pastes.
score: 0.36130263, Nature chemical biology, 2008, Carrico, Isaac
Commercial scale biocatalysis: myths and realities
score: 0.36105313, Bioorganic & Medicinal Chemistry, 1999, Rozzell, J.David
Combining docking with pharmacophore filtering for improved virtual screening
score: 0.36064938, Journal of Cheminformatics, 2009, Peach, Megan L; Nicklaus, Marc C
Trp modification signals a quorum.
score: 0.36022256, Nature chemical biology, 2005, Gibbs, Richard A
Inhibition of rat liver microsomal lipid peroxidation elicited by 2,2-dimethylchromenes and chromans containing fluorinated moieties resistant to cytochrome P-450 metabolism
score: 0.36001931, Bioorganic & Medicinal Chemistry, 1993, Irurre, Josep et. al.
Structure-activity relationship studies of CNS agents-XVII. Spiro[piperidine-4′,1-(1,2,3,4-tetrahydro-β-carboline)] as a probe defining the extended topographic model of 5-HT 1A receptors
score: 0.36000899, Bioorganic & Medicinal Chemistry, 1995, Mokrosz, Maria J. et. al.
Synthesis and antitumour activity of a new series of nitrosoureido sugars
score: 0.35898106, European Journal of Medicinal Chemistry, 2000, Monneret, Claude et. al.
Modest membrane hydrogen bonds deliver rich results.
score: 0.3588797, Nature chemical biology, 2008, Grigoryan, Gevorg; Degrado, William F
New strategy in synthetic biology: from enzyme inhibition and natural products synthesis to PET imaging by 6pi-azaelectrocyclization.
score: 0.35874704, Chemical record (New York, N.Y.), 2010, Tanaka, Katsunori; Fukase, Koichi; Katsumura, Shigeo
From carbohydrate leads to glycomimetic drugs.
score: 0.3586009, Nature reviews. Drug discovery, 2009, Ernst, Beat; Magnani, John L
Functional epitopes at the ribosome subunit interface.
score: 0.35854433, Nature chemical biology, 2006, Rackham, Oliver; Wang, Kaihang; Chin, Jason W
Conformational changes of small molecules binding to proteins
score: 0.35834897, Bioorganic & Medicinal Chemistry, 1995, Nicklaus, Marc C. et. al.
Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers.
score: 0.35802832, Nature chemical biology, 2011, Qin, Kou; Dong, Chunmin; Wu, Guangyu; Lambert, Nevin A
The siderophore yersiniabactin binds copper to protect pathogens during infection
score: 0.35796911, Nature chemical biology, 2012, Chaturvedi, Kaveri S. et. al.
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei.
score: 0.35781944, Proceedings of the National Academy of Sciences of the United States of America, 2008, Amaro, Rommie E et. al.
Biomaterials: spider strength and stretchability.
score: 0.3578123, Nature chemical biology, 2010, Linke, Wolfgang A
FTIR analysis of GPCR activation using azido probes.
score: 0.35748577, Nature chemical biology, 2009, Ye, Shixin; Huber, Thomas; Vogel, Reiner; Sakmar, Thomas P
New in 2009.
score: 0.35740352, Nature chemical biology, 2009,
Inactivation of monoamine oxidase B by benzyl 1-(aminomethyl)cyclopropane-1-carboxylate
score: 0.35727052, Bioorganic & Medicinal Chemistry, 1997, Silverman, Richard B. et. al.
A 21st century revisionist's view at a turning point in enzymology.
score: 0.3566355, Nature chemical biology, 2009, Nagel, Zachary D; Klinman, Judith P
Synthesis, Src kinase inhibitory and anticancer activities of 1-substituted 3-( N-alkyl- N-phenylamino)propane-2-ols
score: 0.35661886, Biochimie, 2010, Sharma, Deepti et. al.
Synthesis of [3′,5′- 3H 2]-α-fluoromethyl-tyrosine as a radioactive specific label of rat brain tyrosine hydroxylase
score: 0.3562891, Bioorganic & Medicinal Chemistry, 1994, Lafargue, Pierre et. al.
Mannich bases of 3 H-pyrrolo[3,2- f]quinoline having vasorelaxing activity
score: 0.35626292, European Journal of Medicinal Chemistry, 2002, Ferlin, Maria Grazia et. al.
The p K a Distribution of Drugs: Application to Drug Discovery
score: 0.35545295, Perspectives in Medicinal Chemistry, 2007, Manallack, David T.
Knot formation in newly translated proteins is spontaneous and accelerated by chaperonins.
score: 0.35497657, Nature chemical biology, 2012, Mallam, Anna L; Jackson, Sophie E
Bacillithiol is an antioxidant thiol produced in Bacilli.
score: 0.35496867, Nature chemical biology, 2009, Newton, Gerald L et. al.
Anti-Trypanosoma cruzi activity of nicotinamide
score: 0.35462102, Acta Tropica, 2012, Soares, Milena B.P. et. al.
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.
score: 0.35406809, Nature chemical biology, 2010, Hagel, Jillian M; Facchini, Peter J
Integration of virtual and high-throughput screening.
score: 0.35377513, Nature reviews. Drug discovery, 2002, Bajorath, Jürgen
Molecular motors: rocking and rolling.
score: 0.35367456, Nature chemical biology, 2005, Amos, Linda A
Crystallographic structure of a peptidyl keto acid inhibitor and human α-thrombin
score: 0.35307859, Bioorganic & Medicinal Chemistry, 1995, Håkansson, Kjell et. al.
Deciphering bacterial language.
score: 0.35307069, Nature chemical biology, 2009, Sperandio, Vanessa
Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
score: 0.3528646, Chemistry & Biology, 2012, Van Molle, Inge et. al.
Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.
score: 0.35246438, Nature chemical biology, 2009, Han, Yang et. al.
Fast 3D shape screening of large chemical databases through alignment-recycling
score: 0.35221428, Chemistry Central Journal, 2007, Fontaine, Fabien et. al.
Trafficking in persulfides: delivering sulfur in biosynthetic pathways.
score: 0.35219655, Nature chemical biology, 2006, Mueller, Eugene G
Control of protein phosphorylation with a genetically encoded photocaged amino acid.
score: 0.35207123, Nature chemical biology, 2007, Lemke, Edward A et. al.
FlexNovo: structure-based searching in large fragment spaces.
score: 0.35155778, ChemMedChem, 2006, Degen, Jörg; Rarey, Matthias
Catalyzing collaboration.
score: 0.35147249, Nature chemical biology, 2007,
Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs
score: 0.35137182, Il Farmaco, 2004, Rapposelli, Simona et. al.
Synthesis and anticonvulsant activity of 4-bromophenyl substituted aryl semicarbazones
score: 0.35133772, European Journal of Medicinal Chemistry, 2000, Pandeya, Surendra N; Yogeeswari, Perumal; Stables, James P
DNG cytidine: synthesis and binding properties of octameric guanidinium-linked deoxycytidine oligomer
score: 0.35132466, Bioorganic & Medicinal Chemistry, 2004, Szabo, Istvan E.; Bruice, Thomas C.
Binding and cleavage characteristics of the complexes formed between the neocarzinostatin chromophore and single site containing oligonucleotides
score: 0.35122708, Bioorganic & Medicinal Chemistry, 1995, Stassinopoulos, Adonis; Goldberg, Irving H.
Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE)
score: 0.35118938, BMC Structural Biology, 2012, Liu, Shu et. al.
Carbohydrate dynamics: Antibody glycans wiggle and jiggle.
score: 0.35106617, Nature chemical biology, 2011, Meier, Sebastian; Duus, Jens
Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads
score: 0.35044529, PLoS Neglected Tropical Diseases, 2011, Ang, Kenny K. H. et. al.
Single molecule analysis reveals three phases of DNA degradation by an exonuclease
score: 0.35036946, Nature chemical biology, 2011, Lee, Gwangrog et. al.
Lipids out of order.
score: 0.35035218, Nature chemical biology, 2008, Veatch, Sarah L
Small molecule displacement of a cryptic degron causes conditional protein degradation
score: 0.35023622, Nature chemical biology, 2011, Bonger, Kimberly M. et. al.
The far reaches of enzymology.
score: 0.3501477, Nature chemical biology, 2009, Zalatan, Jesse G; Herschlag, Daniel
GPIs on a chip.
score: 0.34984694, Nature chemical biology, 2008, Ferguson, Michael A J
Molecular modeling studies of pyridopurinone derivatives—Potential phosphodiesterase 5 inhibitors
score: 0.34969676, Journal of Molecular Graphics and Modelling, 2007, Srivani, P.; Srinivas, E.; Raghu, R.; Sastry, G. Narahari
In situ assembly of enzyme inhibitors using extended tethering.
score: 0.34963474, Nature biotechnology, 2003, Erlanson, Daniel A et. al.
Unexpected tails of a Ca2+ sensor.
score: 0.34958214, Nature chemical biology, 2008, Haynes, Lee P; Burgoyne, Robert D
A glycopeptide regulating stem cell fate in Arabidopsis thaliana.
score: 0.34955938, Nature chemical biology, 2009, Ohyama, Kentaro et. al.
Synthesis of key analogs of bleomycin A 2 that permit a systematic evaluation of the linker region: Identification of an exceptionally prominent role for the l-threonine substituent
score: 0.34926534, Bioorganic & Medicinal Chemistry, 1995, Boger, Dale L. et. al.
At the crossroad of thiamine degradation and biosynthesis.
score: 0.34921537, Nature chemical biology, 2007, Bettendorff, Lucien
Estimation of drug solubility in water, PEG 400 and their binary mixtures using the molecular structures of solutes
score: 0.34912552, European Journal of Pharmaceutical Sciences, 2010, Ghafourian, Taravat; Bozorgi, Atefeh Haji Agha
Glycobiology: Cellulose squeezes through.
score: 0.34876502, Nature chemical biology, 2010, Endler, Anne; Sánchez-Rodríguez, Clara; Persson, Staffan
Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs
score: 0.34848097, European Journal of Pharmaceutical Sciences, 2010, Tsai, Hsing-Ju et. al.
Fast-tracking steroid receptor crystallization.
score: 0.34793915, Nature chemical biology, 2008, Mader, Sylvie
Chromatographic retention parameters in correlation analysis with in silico biological descriptors of a novel series of N-phenyl-3-methyl succinimide derivatives
score: 0.34788454, Journal of Pharmaceutical and Biomedical Analysis, 2013, Perisic-Janjic, Nada et. al.
Chromatographic retention parameters in correlation analysis with in silico biological descriptors of a novel series of N-phenyl-3-methyl succinimide derivatives
score: 0.34788454, Journal of Pharmaceutical and Biomedical Analysis, 2013, Perisic-Janjic, Nada et. al.
Scoring functions and enrichment: a case study on Hsp90
score: 0.34785962, BMC Bioinformatics, 2007, Konstantinou-Kirtay, Chrysi et. al.
Biosynthesis: is it time to go retro?
score: 0.34742261, Nature chemical biology, 2010, Bachmann, Brian O
Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines.
score: 0.34715649, Antimicrobial agents and chemotherapy, 1995, Vennerstrom, J L et. al.
Acetoacetate decarboxylase: hydrophobics, not electrostatics.
score: 0.34675808, Nature chemical biology, 2009, Gerlt, John A
DNA-encoded chemical libraries
score: 0.34658349, Journal of Biotechnology, 2006, Scheuermann, Jörg et. al.
Synthesis and biological evaluation of O-alkylated tropolones and related α-ketohydroxy derivatives as ribonucleotide reductase inhibitors
score: 0.34656683, European Journal of Medicinal Chemistry, 2001, Tamburlin-Thumin, Isabelle et. al.
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers.
score: 0.34651197, Nature chemical biology, 2011, Lee, Jiyong et. al.
Orchestrating sulfur incorporation into RNA.
score: 0.34645186, Nature chemical biology, 2006, Lauhon, Charles T
Reaction of β-Alkannin (Shikonin) with Reactive Oxygen Species: Detection of β-Alkannin Free Radicals
score: 0.34597971, Bioorganic & Medicinal Chemistry, 2000, Gao, Dayuan et. al.
The nanny model for IDPs.
score: 0.34580771, Nature chemical biology, 2009, Tsvetkov, Peter; Reuven, Nina; Shaul, Yosef
Functionalized 3,5-dihydroxybenzoates as potent novel inhibitors of EPSP synthase
score: 0.34565933, Bioorganic & Medicinal Chemistry, 1994, Miller, Michael J. et. al.
In silico pharmacology for drug discovery: applications to targets and beyond.
score: 0.3451233, British journal of pharmacology, 2007, Ekins, S; Mestres, J; Testa, B
Synthesis of glycyrrhizin analogues containing fluorinated β(1→2)-linked disaccharides
score: 0.34511657, Bioorganic & Medicinal Chemistry, 1996, Morishima, Naohiko; Mori, Yoko
Revisiting the ancient concept of botanical therapeutics.
score: 0.3449101, Nature chemical biology, 2007, Schmidt, Barbara M et. al.
Analysis of drug-induced effect patterns to link structure and side effects of medicines.
score: 0.34437369, Nature chemical biology, 2005, Fliri, Anton F et. al.
Prediction and assignment of function for a divergent N-succinyl amino acid racemase.
score: 0.34426954, Nature chemical biology, 2007, Song, Ling et. al.
Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.
score: 0.3442559, Antimicrobial agents and chemotherapy, 1996, Oram, M et. al.
Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases)
score: 0.34418508, Purinergic Signalling, 2008, Baqi, Younis et. al.
Extracellular redox modulation by regulatory T cells.
score: 0.34407755, Nature chemical biology, 2009, Yan, Zhonghua et. al.
Nucleation of huntingtin aggregation in cells.
score: 0.34399868, Nature chemical biology, 2006, Wetzel, Ronald
Lipid-induced phenotypes.
score: 0.3439414, Nature chemical biology, 2006, Schultz, Carsten
TRPA1 underlies a sensing mechanism for O2.
score: 0.34370557, Nature chemical biology, 2011, Takahashi, Nobuaki et. al.
Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids.
score: 0.34365722, Nature chemical biology, 2011, Long, Jonathan Z et. al.
Novel cytotoxic DNA sequence and minor groove targeted photosensitizers: Conjugates of pyrene and netropsin analogues
score: 0.34343632, Bioorganic & Medicinal Chemistry, 1995, Hartley, John A. et. al.
Imaging G protein-coupled receptor islands.
score: 0.34339817, Nature chemical biology, 2005, Park, Paul S-H; Palczewski, Krzysztof
Back to school.
score: 0.34239129, Nature chemical biology, 2005,
Signal transduction: STIM1 senses both Ca²+ and heat.
score: 0.34239129, Nature chemical biology, 2011, Mancarella, Salvatore; Wang, Youjun; Gill, Donald L
The ivory tower grays.
score: 0.34239129, Nature chemical biology, 2007,
Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studies.
score: 0.34182662, Chemical biology & drug design, 2012, Shan, Jufang et. al.
Structural landscape of the isolated ligand binding domain of single AMPA receptors
score: 0.34161107, Nature chemical biology, 2011, Landes, Christy F. et. al.
Dialkylaminoalkyl esters of 2,2-diphenyl-2-alkylthioacetic acids: A new class of potent and functionally selective muscarinic antagonists
score: 0.34144252, Bioorganic & Medicinal Chemistry, 1994, Scapecchi, S. et. al.
Taking the inventory inside single cells.
score: 0.3414015, Nature chemical biology, 2007, Balázsi, G; Collins, J J
Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist
score: 0.34079545, European Journal of Medicinal Chemistry, 2000, Madsen, Ulf et. al.
Synthesis and cytotoxicity of artemisinin derivatives containing cyanoarylmethyl group
score: 0.34042882, European Journal of Medicinal Chemistry, 2001, Wu, Jin-Ming et. al.
Inquiry-based and research-based laboratory pedagogies in undergraduate science.
score: 0.34031175, Nature chemical biology, 2008, Weaver, Gabriela C; Russell, Cianán B; Wink, Donald J
Light-controlled gene silencing in zebrafish embryos.
score: 0.33925348, Nature chemical biology, 2007, Shestopalov, Ilya A; Sinha, Surajit; Chen, James K
Deciphering ligand dependent degree of binding site closure and its implication in inhibitor design: A modeling study on human adenosine kinase
score: 0.33920524, Journal of Molecular Graphics and Modelling, 2010, Bhutoria, Savita; Ghoshal, Nanda
Synthesis and biological evaluation of polyhydroxycurcuminoids
score: 0.33919807, Bioorganic & Medicinal Chemistry, 2005, Venkateswarlu, Somepalli et. al.
#science communication.
score: 0.33891027, Nature chemical biology, 2009,
Structural modifications induced during biodegradation of wheat lignin by Lentinula edodes
score: 0.33888464, Bioorganic & Medicinal Chemistry, 1998, Crestini, Claudia et. al.
Synthetic DNA minor groove-binding drugs ☆ ☆ Editor's Note: Figures 1–99 appear throughout text. Structures 1–271 appear together at the end of this article, although Structures 25, 111–147, 162–181, 182–188, and 241–255 also appear within Tables 1–5.
score: 0.33836714, Pharmacology and Therapeutics, 1999, Reddy, B.S.Praveen; Sondhi, S.Murari; Lown, J.William
Mining collections of compounds with Screening Assistant 2
score: 0.33828793, Journal of Cheminformatics, 2012, Guilloux, Vincent Le et. al.
Design, synthesis and evaluation of bouvardin, deoxybouvardin and RA-I-XIV pharmacophore analogs
score: 0.33799339, Bioorganic & Medicinal Chemistry, 1994, Boger, Dale L. et. al.
A unified mechanism of action for volatile isoprenoids in plant abiotic stress.
score: 0.33790345, Nature chemical biology, 2009, Vickers, Claudia E et. al.
Natural and synthetic cage compounds incorporating the 2,9,10-trioxatricyclo[4.3.1.0 3,8]decane type moiety
score: 0.33779204, Bioorganic & Medicinal Chemistry, 2005, Stanoeva, Elena; He, Weidong; De Kimpe, Norbert
DNA-catalyzed hydrolysis of DNA phosphodiesters.
score: 0.33760286, Nature chemical biology, 2009, Fekry, Mostafa I; Gates, Kent S
Systems biology: Hypothesis-driven omics integration.
score: 0.33707518, Nature chemical biology, 2010, Schmid, Andreas; Blank, Lars M
Untangling the estrogen receptor web.
score: 0.33694274, Nature chemical biology, 2006, Weatherman, Ross V
Synthesis and biological properties of substituted 1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acids
score: 0.33636935, Bioorganic & Medicinal Chemistry, 1995, Miyamoto, Hisashi et. al.
20-(S)-camptothecin analogues as DNA topoisomerase I inhibitors: a QSAR study.
score: 0.33579719, ChemMedChem, 2007, Hansch, Corwin; Verma, Rajeshwar P
Conformational diversity of T-kinin in DMSO, water and HFA
score: 0.33522678, European Journal of Medicinal Chemistry, 2002, Desai, Prashant; Coutinho, Evans; Srivastava, Sudha
Multiple ligand-specific conformations of the β2-adrenergic receptor.
score: 0.33516356, Nature chemical biology, 2011, Kahsai, Alem W et. al.
Membrane trafficking: Arls squeeze the fat out.
score: 0.33428621, Nature chemical biology, 2011, Williams, Roger L
Sublancin is not a lantibiotic but an S -linked glycopeptide
score: 0.33411425, Nature chemical biology, 2011, Oman, Trent J. et. al.
Site-specific PEGylation of native disulfide bonds in therapeutic proteins.
score: 0.33336895, Nature chemical biology, 2006, Shaunak, Sunil et. al.
Synthesis and characterization of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton
score: 0.33335622, Chemistry Central Journal, 2010, Li, Juan; Li, Hongqi; Li, Yijing
Synthesis and elastase inhibitory activity of 6α-chloro-2,2-dimethyl-3α-(pivaloyloxy)methylpenam sulfone, 6α-chloro-2,2-dimethyl-3- exo-methylenepenam sulfone, benzyl and methyl 6α-substituted penicillanate sulfones
score: 0.3329281, Bioorganic & Medicinal Chemistry, 1995, Boschetti, Carlos E. et. al.
Hot springs and cool natural products.
score: 0.3329032, Nature chemical biology, 2008, Kwon, Ho Jeong et. al.
QSAR, docking and in vivo studies for immunomodulatory activity of isolated triterpenoids from Eucalyptus tereticornis and Gentiana kurroo
score: 0.33235816, European Journal of Pharmaceutical Sciences, 2012, Maurya, Anupam et. al.
QSAR, docking and in vivo studies for immunomodulatory activity of isolated triterpenoids from Eucalyptus tereticornis and Gentiana kurroo
score: 0.33235816, European Journal of Pharmaceutical Sciences, 2012, Maurya, Anupam et. al.
Double bond isosteres of the peptide bond: Synthesis and biological activity of cholecystokinin (CCK) C-terminal hexapeptide analogs
score: 0.33229499, Bioorganic & Medicinal Chemistry, 1993, Shue, Youe-Kong et. al.
Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.
score: 0.33219281, ChemMedChem, 2009, Spinks, Daniel et. al.
Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
score: 0.33065158, Scientia Pharmaceutica, 2011, Bielenica, Anna et. al.
The proteoglycan bikunin has a defined sequence.
score: 0.33042488, Nature chemical biology, 2011, Ly, Mellisa et. al.
IP7 guards the CDK gate.
score: 0.3303415, Nature chemical biology, 2008, York, John D; Lew, Daniel J
Synthesis, molecular structure and anticancer activity of 1-allyl-3-amino-2-(4-chloro-2-mercaptobenzenesulphonyl)guanidine derivatives
score: 0.33008139, European Journal of Medicinal Chemistry, 2002, Brzozowski, Z; Sączewski, F; Gdaniec, M
Natural amino acids do not require their native tRNAs for efficient selection by the ribosome
score: 0.32982159, Nature chemical biology, 2009, Effraim, Philip R. et. al.
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.
score: 0.32972542, Proceedings of the National Academy of Sciences of the United States of America, 2008, Hellmuth, Klaus et. al.
Synthesis, biodistribution and PET studies in rats of 18F-Labeled bridgehead fluoromethyl analogues of WAY-100635
score: 0.32946916, Nuclear Medicine and Biology, 2012, Al Hussainy, Rana et. al.
Single-molecule analysis of human telomerase monomer.
score: 0.3283647, Nature chemical biology, 2008, Alves, David et. al.
Syntheses and molecular structures of 3- N, N-di- n-Propylamino-2-chromanones as new analogues of dopamine
score: 0.32779124, Bioorganic & Medicinal Chemistry, 1995, Benoit-Guyod, Martine et. al.
Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.
score: 0.32733747, Nature chemical biology, 2007, Janowski, Bethany A et. al.
Engineering ingenuity at iGEM.
score: 0.32732003, Nature chemical biology, 2008, Goodman, Catherine
The physical chemistry of membrane curvature.
score: 0.32686905, Nature chemical biology, 2009, Groves, Jay T
The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.
score: 0.32684637, Nature chemical biology, 2010, Vetting, Matthew W; Hegde, Subray S; Blanchard, John S
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells.
score: 0.32680062, Nature chemical biology, 2006, Feyerabend, Thorsten B et. al.
An autocatalytic network for ribozyme self-construction.
score: 0.32607841, Nature chemical biology, 2008, Seelig, Burckhard
Not all quiet on the noise front.
score: 0.32581152, Nature chemical biology, 2009, McCullagh, Emma et. al.
Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-Diaminopropionic acid derivatives as surrogates of aspartic acid
score: 0.32543575, Bioorganic & Medicinal Chemistry, 1997, Xue, Chu-Biao et. al.
Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs
score: 0.32504168, Bioorganic & Medicinal Chemistry, 2011, Steger, Jessica; Micura, Ronald
A more discerning zinc exporter.
score: 0.32466905, Nature chemical biology, 2007, Robinson, Nigel J
Effect of conformation of the substrate on enzymatic eecarboxylation of α-Arylmalonic Acid
score: 0.32463495, Bioorganic & Medicinal Chemistry, 1994, Miyamoto, Kenji; Ohta, Hiromichi; Osamura, Yoshihiro
Evolving molecules using multi-objective optimization: applying to ADME/Tox
score: 0.3245433, Drug Discovery Today, 2010, Ekins, Sean; Honeycutt, J. Dana; Metz, James T.
Proteomes take the electrophilic bait.
score: 0.32393604, Nature chemical biology, 2008, Kodadek, Thomas
Receptors: cannabis medicine without a high.
score: 0.32312791, Nature chemical biology, 2011, Christie, Macdonald J; Vaughan, Christopher W
Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus
score: 0.32306742, BMC Bioinformatics, 2011, Lim, See Ven; Rahman, Mohd Basyaruddin A ; Tejo, Bimo A
An Orthosteric Inhibitor of the Ras-Sos Interaction
score: 0.32279924, Nature Chemical Biology, 2011, Patgiri, Anupam et. al.
3D-QSAR analysis of cycloguanil derivatives as inhibitors of A16V + S108T mutant Plasmodium falciparum dihydrofolate reductase enzyme
score: 0.32265432, Journal of Molecular Graphics and Modelling, 2009, Adane, Legesse; Bharatam, Prasad V.
Domain organization differences explain Bcr-Abl’s preference for CrkL over CrkII
score: 0.32257147, Nature chemical biology, 2012, Jankowski, Wojciech et. al.
Soft drugs—XIV. Synthesis and anticholinergic activity of soft phenylsuccinic analogs of methatropine
score: 0.3223787, Bioorganic & Medicinal Chemistry, 1993, Hammer, R.H. et. al.
New light on an open-and-shut case.
score: 0.32184868, Nature chemical biology, 2005, Madden, Dean R
Extracellular Redox Modulation by Regulatory T Cells †
score: 0.32178696, Nature chemical biology, 2009, Yan, Zhonghua et. al.
Unlocking the lipid labyrinth.
score: 0.32169955, Nature chemical biology, 2010,
Synthesis of 4-methyl-thio-phenyl-propylamine and the evaluation of its interaction with different amine oxidases
score: 0.32121589, Bioorganic & Medicinal Chemistry, 2004, Gallardo-Godoy, Alejandra et. al.
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli.
score: 0.32080516, Nature chemical biology, 2009, Bennett, Bryson D et. al.
Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model.
score: 0.32072827, The Journal of pharmacology and experimental therapeutics, 2011, Wu, Baojian et. al.
Recent advances in the development of selective human MAO-B inhibitors: (Hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines
score: 0.32053871, European Journal of Medicinal Chemistry, 2012, Secci, Daniela et. al.
Nitrate and nitrite in biology, nutrition and therapeutics.
score: 0.32051535, Nature chemical biology, 2009, Lundberg, Jon O et. al.
Affinity probes for the GABA-gated chloride channel: 5 e- tert-Butyl-2 e-[4-(substituted-ethynyl)phenyl]-1,3-dithianes with photoactivatable, fluorescent, biotin, agarose and protein substituents
score: 0.3204289, Bioorganic & Medicinal Chemistry, 1995, Li, Qing X.; Casida, John E.
Virtual screening filters for the design of type II p38 MAP kinase inhibitors: A fragment based library generation approach
score: 0.32026652, Journal of Molecular Graphics and Modelling, 2012, Badrinarayan, Preethi; Sastry, G. Narahari
Virtual screening filters for the design of type II p38 MAP kinase inhibitors: A fragment based library generation approach
score: 0.32026652, Journal of Molecular Graphics and Modelling, 2012, Badrinarayan, Preethi; Sastry, G. Narahari
Synthesis, antitumour and antimicrobial activities of new peptidyl derivatives containing the 1,3-benzodioxole system
score: 0.31934628, European Journal of Medicinal Chemistry, 2004, Leite, Ana Cristina Lima et. al.
PKR and the ribosome compete for mRNA.
score: 0.31908238, Nature chemical biology, 2009, Toroney, Rebecca; Bevilacqua, Philip C
Identifying polyglutamine protein species in situ that best predict neurodegeneration
score: 0.31901193, Nature Chemical Biology, 2011, Miller, Jason et. al.
Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.
score: 0.31860336, Nature chemical biology, 2012, Sample, Vedangi et. al.
Antibiotics: inactive but not inert.
score: 0.3182873, Nature chemical biology, 2010, Wright, Gerard D
Grand challenge commentary: Chassis cells for industrial biochemical production.
score: 0.31769177, Nature chemical biology, 2010, Vickers, Claudia E; Blank, Lars M; Krömer, Jens O
Protein dynamics under light control.
score: 0.31744795, Nature chemical biology, 2008, Vendruscolo, Michele
A QUICk look at O-GlcNAc dynamics.
score: 0.31733509, Nature chemical biology, 2007, Wells, Lance
Biosynthesis: Ringing in a new view.
score: 0.31726567, Nature chemical biology, 2012, Kelly, Wendy L
Using SAR and QSAR analysis to model the activity and structure of the quinolone—DNA complex
score: 0.31723799, Bioorganic & Medicinal Chemistry, 1996, Llorente, Belsis; Leclerc, Fabrice; Cedergren, Robert
Depsides as non-redox inhibitors of leukotriene B 4 biosynthesis and HaCaT cell growth, 2. Novel analogues of obtusatic acid
score: 0.31620496, European Journal of Medicinal Chemistry, 2000, Kumar KC, Sunil; Müller, Klaus
The emerging biology of the nitrite anion.
score: 0.31605151, Nature chemical biology, 2005, Gladwin, Mark T et. al.
Structure-based Ligand Design and the Promise Held for Antiprotozoan Drug Discovery *
score: 0.31604046, The Journal of Biological Chemistry, 2009, Hunter, William N.
Adenosyltransferase tailors and delivers coenzyme B12.
score: 0.31592516, Nature chemical biology, 2008, Padovani, Dominique et. al.
Physiochemical property space distribution among human metabolites, drugs and toxins
score: 0.31589666, BMC Bioinformatics, 2009, Khanna, Varun; Ranganathan, Shoba
Glycosylated flavones as selective inhibitors of topoisomerase IV.
score: 0.31588401, Antimicrobial agents and chemotherapy, 1997, Bernard, F X et. al.
Structure–activity relationships and optimisation of the selective MDR modulator 2-(3,4-dimethoxyphenyl)-5-(9-fluorenylamino)-2-(methylethyl) pentanenitrile and its N-methyl derivative
score: 0.31531737, Bioorganic & Medicinal Chemistry, 2001, Dei, Silvia et. al.
Synthesis and antibacterial study of unsaturated Mannich ketones
score: 0.31505348, European Journal of Medicinal Chemistry, 2001, Lóránd, Tamás et. al.
Chemo-metabolic regulation of immune responses by Tregs.
score: 0.314715, Nature chemical biology, 2009, Rubartelli, Anna; Sitia, Roberto
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
score: 0.3143068, Nature chemical biology, 2010, Bao, Guanhu et. al.
Bacterial outer membrane evolution via sporulation?
score: 0.31394811, Nature chemical biology, 2012, Vollmer, Waldemar
Synthesis of an immunologically active analog of thymic humoral factor-γ 2 with enhanced enzymatic stability
score: 0.31386609, Bioorganic & Medicinal Chemistry, 1994, Abiko, Takashi; Sekino, Hiroshi
Slip sliding away: new insights into DNA-protein recognition.
score: 0.3138641, Nature chemical biology, 2006, Dahlquist, Frederick W
Synthesis and antitubercular activity of 3-aryl substituted-2-(1 H(2 H)benzotriazol-1(2)-yl)acrylonitriles # 1 # Part of this work was presented as a poster communication at the 2nd European Symposium on Antimicrobial Agents, Hradec Kralove, Czech Republic, 1–4 July 1998.
score: 0.31359797, European Journal of Medicinal Chemistry, 2000, Sanna, Paolo; Carta, Antonio; Nikookar, Mohammad E.Rahbar
Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure
score: 0.31343348, Theoretical Biology & Medical Modelling, 2009, Ravna, Aina W; Sylte, Ingebrigt; Sager, Georg
Approaches for Identification of HIV-1 Entry Inhibitors Targeting gp41 Pocket
score: 0.31304289, Viruses, 2013, Yu, Fei et. al.
Sensing cellular stress through STIM proteins.
score: 0.31267641, Nature chemical biology, 2011, Soboloff, Jonathan; Madesh, Muniswamy; Gill, Donald L
From eye of newt to chemical structure.
score: 0.31260602, Nature chemical biology, 2007, Sengupta, Piali; Thomas, James H
Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.
score: 0.31255462, Nature chemical biology, 2011, Hagel, Margit et. al.
Watching proteases in action.
score: 0.31228551, Nature chemical biology, 2005, Brix, Klaudia; Jordans, Silvia
DNA damage tolerance: when it's OK to make mistakes.
score: 0.31213675, Nature chemical biology, 2009, Chang, Debbie J; Cimprich, Karlene A
Cardiolipin oxidation sets cytochrome c free.
score: 0.31210346, Nature chemical biology, 2005, Orrenius, Sten; Zhivotovsky, Boris
Engineering protease specificity made simple, but not simpler.
score: 0.31177834, Nature chemical biology, 2008, Di Cera, Enrico
Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1
score: 0.3117368, PLoS Neglected Tropical Diseases, 2010, Durrant, Jacob D. et. al.
The cyano-NNO-azoxy function in the design of an irreversible label for α 1 adrenoreceptors
score: 0.31164318, Bioorganic & Medicinal Chemistry, 1995, Sorba, G. et. al.
Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.
score: 0.31155207, Nature chemical biology, 2011, Neklesa, Taavi K et. al.
Rhodopsin-Transducin Interface: Studies with Conformationally Constrained Peptides
score: 0.31147606, Biophysical Journal, 2001, Arimoto, Rieko et. al.
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development
score: 0.31114535, Nature chemical biology, 2011, Shestopalov, Ilya A.; Pitt, Cameron L. W.; Chen, James K.
Purification and characterisation of an ester hydrolase from a strain of Arthrobacter species
score: 0.31113183, Bioorganic & Medicinal Chemistry, 2001, Johri, S et. al.
Single-molecule analysis reveals three phases of DNA degradation by an exonuclease.
score: 0.31113025, Nature chemical biology, 2011, Lee, Gwangrog; Yoo, Jungmin; Leslie, Benjamin J; Ha, Taekjip
Binding of peptides in solution by the Escherichia coli chaperone PapD as revealed using an inhibition ELISA and NMR spectroscopy
score: 0.31084224, Bioorganic & Medicinal Chemistry, 1998, Flemmer Karlsson, Katarina et. al.
Imaging single events at the cell membrane.
score: 0.31043799, Nature chemical biology, 2007, Jaiswal, Jyoti K; Simon, Sanford M
Fragment-based activity space: smaller is better
score: 0.3098227, Current Opinion in Chemical Biology, 2008, Hesterkamp, Thomas; Whittaker, Mark
Alternative DNA structures: G4 DNA in cells: itae missa est?
score: 0.30952499, Nature chemical biology, 2012, Mergny, Jean-Louis
The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.
score: 0.30936589, Nature chemical biology, 2009, Kelly, Robert C et. al.
Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis.
score: 0.30926854, Nature chemical biology, 2010, Ong, Derrick Sek Tong et. al.
Flexible tetracycline synthesis yields promising antibiotics.
score: 0.30876039, Nature chemical biology, 2009, Burke, Martin D
Analyzing the dynamic bacterial glycome with a lectin microarray approach.
score: 0.30869711, Nature chemical biology, 2006, Hsu, Ku-Lung; Pilobello, Kanoelani T; Mahal, Lara K
Adenosine receptor agonists: Synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA
score: 0.30869298, Bioorganic & Medicinal Chemistry, 1997, Camaioni, Emidio et. al.
Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.
score: 0.30839451, Nature chemical biology, 2011, Xiong, Wei et. al.
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies
score: 0.30837271, Biochemical Pharmacology, 2008, Chen, Gong et. al.
Synthesis of DEHP metabolites as biomarkers for GC–MS evaluation of phthalates as endocrine disrupters
score: 0.30835974, Bioorganic & Medicinal Chemistry, 2005, Nuti, Francesca et. al.
A metabolic network described in absolute terms.
score: 0.3082365, Nature chemical biology, 2009, Schomburg, Dietmar
In vitro reconstruction of tetronate RK-682 biosynthesis
score: 0.3080749, Nature chemical biology, 2009, Sun, Yuhui et. al.
Natural products at the Hans Knöll Institute.
score: 0.30775943, Nature chemical biology, 2007, Goodman, Catherine
3D-QSAR and molecular docking studies of selective agonists for the thyroid hormone receptor β
score: 0.3076304, Journal of Molecular Graphics and Modelling, 2008, Du, Juan; Qin, Jin; Liu, Huanxiang; Yao, Xiaojun
FAF-Drugs: free ADME/tox filtering of compound collections
score: 0.30742417, Nucleic Acids Research, 2006, Miteva, Maria A. et. al.
A network of orthogonal ribosome x mRNA pairs.
score: 0.30735726, Nature chemical biology, 2005, Rackham, Oliver; Chin, Jason W
Structure-activity studies of endothelin leading to novel peptide ET A antagonists
score: 0.30621426, Bioorganic & Medicinal Chemistry, 1993, Hunt, John T. et. al.
Multiple DNA binding modes of anthracene-9-carbonyl- N 1-spermine
score: 0.30610129, Bioorganic & Medicinal Chemistry, 1995, Rodger, Alison et. al.
Solving an old puzzle in phospholipid biosynthesis.
score: 0.30604509, Nature chemical biology, 2006, Schujman, Gustavo E; de Mendoza, Diego
α-ketoglutarate coordinates carbon and nitrogen utilization via Enzyme I inhibition
score: 0.30603176, Nature Chemical Biology, 2011, Doucette, Christopher D et. al.
Making the step from chemistry to biology and back.
score: 0.30578351, Nature chemical biology, 2007, Goodsell, David S
Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus.
score: 0.30556531, Antimicrobial agents and chemotherapy, 1995, Sumita, Y; Nouda, H; Kanazawa, K; Fukasawa, M
Conformationally constrained analogues of endogenous tripeptide inhibitors of zinc metalloproteinases
score: 0.30556344, European Journal of Medicinal Chemistry, 2001, D'Alessio, Silvana et. al.
Learning science like a scientist.
score: 0.30534276, Nature chemical biology, 2006,
Tools, tricks and trade secrets: the challenges of disseminating methodology.
score: 0.30524671, Nature chemical biology, 2007, Lutz, Stefan
Discovery of Isoerianin Analogues as Promising Anticancer Agents.
score: 0.30493652, ChemMedChem, 2011, Messaoudi, Samir et. al.
Methionine recycling pathways and antimalarial drug design.
score: 0.30492718, Antimicrobial agents and chemotherapy, 1995, Sufrin, J R et. al.
Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives
score: 0.30477762, European Journal of Medicinal Chemistry, 2006, Sassatelli, Mathieu et. al.
Amyloidogenesis: FlAsH illuminates Aβ aggregation.
score: 0.30440307, Nature chemical biology, 2011, Outeiro, Tiago F
Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site.
score: 0.3043712, Nature chemical biology, 2012, Nieto-Posadas, Andrés et. al.
Immunology: Csk keeps LYP on a leash.
score: 0.30410809, Nature chemical biology, 2012, Zhong, Ming-Chao; Veillette, André
A New Class of Phytoestrogens
score: 0.3040988, Chemistry & Biology, 2004, Fokialakis, Nikolas et. al.
Microbial environments confound antibiotic efficacy.
score: 0.3039785, Nature chemical biology, 2011, Lee, Henry H; Collins, James J
Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.
score: 0.30387772, Molecular pharmacology, 2007, McKay, Dennis B et. al.
Post-translational modifications: A shift for the O-GlcNAc paradigm.
score: 0.30369358, Nature chemical biology, 2010, Kohler, Jennifer J
Glycobiology: Enzyme deficiencies deciphered.
score: 0.30360679, Nature chemical biology, 2012, Kjellén, Lena
Photochemical tools for remote control of ion channels in excitable cells.
score: 0.30356002, Nature chemical biology, 2005, Kramer, Richard H; Chambers, James J; Trauner, Dirk
A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARγ partial agonists.
score: 0.30339404, ChemMedChem, 2011, Vidović, Dušica et. al.
Are we there yet?
score: 0.3033303, Nature chemical biology, 2007, Merrick, William C
Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus.
score: 0.302787, Antimicrobial agents and chemotherapy, 1996, Takenouchi, T et. al.
Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis.
score: 0.30266327, Nature reviews. Microbiology, 2008, Sacchettini, James C; Rubin, Eric J; Freundlich, Joel S
Women at work.
score: 0.30260575, Nature chemical biology, 2011,
New nitrogen mustards structurally related to ( l)-Carnitine
score: 0.30256423, Bioorganic & Medicinal Chemistry, 2003, Faissat, Ludovic et. al.
Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.
score: 0.30202065, Angewandte Chemie (International ed. in English), 2007, Milroy, Lech-Gustav et. al.
Structural biology: CrkL is not Crk-like.
score: 0.30195332, Nature chemical biology, 2012, Kobashigawa, Yoshihiro; Inagaki, Fuyuhiko
(2,3)-(α-methylenepenams: Synthesis and in vitro activity
score: 0.30171129, Bioorganic & Medicinal Chemistry, 1993, Wei, C.-C. et. al.
Navigating the RNA folding landscape.
score: 0.30169208, Nature chemical biology, 2008, Gonzalez, Ruben L
Keeping it real.
score: 0.30160196, Nature chemical biology, 2007,
A Novel Inhibitor of Dengue Virus Replication that Targets the Capsid Protein.
score: 0.30108508, Antimicrobial agents and chemotherapy, 2012, Byrd, Chelsea M et. al.
Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening
score: 0.30102475, Journal of Molecular Biology, 2004, Brenk, Ruth et. al.
Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis.
score: 0.30025864, Nature chemical biology, 2009, Ruiz, Amparo et. al.
How to evolve a silk purse from a sow's ear.
score: 0.30017325, Nature chemical biology, 2006, Cane, David E
Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.
score: 0.29995757, Nature chemical biology, 2010, Netz, Daili J A et. al.
Chemical biology at the US National Science Foundation.
score: 0.29995368, Nature chemical biology, 2008, Colón, Wilfredo et. al.
Mussel protein adhesion depends on interprotein thiol-mediated redox modulation.
score: 0.29987169, Nature chemical biology, 2011, Yu, Jing et. al.
Mass spectrometry-based proteomics turns quantitative.
score: 0.29980839, Nature chemical biology, 2005, Ong, Shao-En; Mann, Matthias
How evolving enzymes can beat the heat and avoid defeat.
score: 0.29967349, Nature chemical biology, 2009, Matsumura, Ichiro; Ivanov, Andrei A
Different polyketide folding modes converge to an identical molecular architecture.
score: 0.29956156, Nature chemical biology, 2006, Bringmann, Gerhard et. al.
GPCRs: Caught in a spectroscopic trap.
score: 0.29891065, Nature chemical biology, 2011, Piehler, Jacob
Vinyl fluoride as a mimic of the ‘intermediate’ enol form in the 5α-reductase transformation: Synthesis and in vitro activity of ( N-1′,1′-Dimethylethyl)-3-haloandrost-3,5-diene-17 β-carboxamides
score: 0.2988197, Bioorganic & Medicinal Chemistry, 1996, Li, Xun et. al.
Biofuels: chimeric synthetic pathways.
score: 0.29848845, Nature chemical biology, 2011, Nielsen, Jens
Plant endophytes as a platform for discovery-based undergraduate science education.
score: 0.29784312, Nature chemical biology, 2007, Strobel, Scott A; Strobel, Gary A
Targeting the spliceosome.
score: 0.297759, Nature chemical biology, 2007, Rymond, Brian
Measuring H2O2 produced in response to cell surface receptor activation.
score: 0.29736912, Nature chemical biology, 2007, Rhee, Sue Goo
Chromatin-level regulation of biosynthetic gene clusters.
score: 0.29734669, Nature chemical biology, 2009, Bok, Jin Woo et. al.
Cofactor-independent oxygenases go it alone.
score: 0.29732273, Nature chemical biology, 2007, Fetzner, Susanne
Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture
score: 0.29732271, European Journal of Medicinal Chemistry, 2004, Refouvelet, Bernard et. al.
Selective ligands as tools to study histamine receptors
score: 0.29722752, European Journal of Medicinal Chemistry, 2000, van der Goot, Henk; Timmerman, Henk
Copper and nitric oxide meet in the plasma.
score: 0.29722283, Nature chemical biology, 2006, Samuel, Tamika K; Gitlin, Jonathan D
3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3β inhibitors
score: 0.29712232, Journal of Molecular Graphics and Modelling, 2007, Dessalew, Nigus; Patel, Dhilon S.; Bharatam, Prasad V.
A ghost in the RNA machine.
score: 0.2966844, Nature chemical biology, 2009, Lehman, Niles
Nuclear replication: Hidden iron-sulfur clusters.
score: 0.29641351, Nature chemical biology, 2011, Bailey, Scott
Cell-selective metabolic labeling of proteins.
score: 0.29562254, Nature chemical biology, 2009, Ngo, John T et. al.
Synthesis of high-specific-radioactivity 4- and 6-[ 18F]fluorometaraminol- PET tracers for the adrenergic nervous system of the heart
score: 0.29526272, Bioorganic & Medicinal Chemistry, 2001, Langer, Oliver et. al.
Digging for answers, smelling a hint of success and tasting triumph.
score: 0.29500199, Nature chemical biology, 2007, Noel, Joseph P
Inactive-state preassembly of G q -coupled receptors and G q heterotrimers
score: 0.29484083, Nature chemical biology, 2011, Qin, Kou; Dong, Chunmin; Wu, Guangyu; Lambert, Nevin A.
Engineering Escherichia coli to produce nonribosomal peptide antibiotics.
score: 0.29452722, Nature chemical biology, 2006, Challis, Gregory L
Three-dimensional quantitative structure-activity relationship studies on c-Src inhibitors based on different docking methods.
score: 0.29446463, Chemical biology & drug design, 2009, Bairy, Santhosh Kumar et. al.
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
score: 0.29412006, Molecular pharmacology, 2005, Schmitz, Alexander et. al.
Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.
score: 0.293835, Antimicrobial agents and chemotherapy, 1993, Byrnes, V W et. al.
A practical philosophy.
score: 0.29382649, Nature chemical biology, 2010,
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development.
score: 0.2938048, Nature chemical biology, 2012, Shestopalov, Ilya A; Pitt, Cameron L W; Chen, James K
Putting data to work.
score: 0.29368881, Nature chemical biology, 2010,
Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes
score: 0.29364081, European Journal of Medicinal Chemistry, 2000, Holla, B.Shivararna; Gonsalves, Richard; Shenoy, Shalini
Zinc availability regulates exit from meiosis in maturing mammalian oocytes.
score: 0.29342297, Nature chemical biology, 2010, Kim, Alison M et. al.
Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases
score: 0.29337359, European Journal of Medicinal Chemistry, 2000, Pandeya, Surendra N et. al.
Homology modeling and virtual screening approaches to identify potent inhibitors of slingshot phosphatase 1
score: 0.29330178, Journal of Molecular Graphics and Modelling, 2013, Park, Hwangseo; Park, So Ya; Ryu, Seong Eon
Homology modeling and virtual screening approaches to identify potent inhibitors of slingshot phosphatase 1
score: 0.29330178, Journal of Molecular Graphics and Modelling, 2013, Park, Hwangseo; Park, So Ya; Ryu, Seong Eon
Hunting down heterogeneity.
score: 0.29309005, Nature chemical biology, 2010,
ERA-Chemistry.
score: 0.29267322, Nature chemical biology, 2008, Donner, Amy
Molecular dynamics simulations of m3-muscarinic receptor activation and QSAR analysis
score: 0.29257667, Bioorganic & Medicinal Chemistry, 1995, Fanelli, Francesca et. al.
In vitro antibacterial activity of different adenosine analogues.
score: 0.2925606, Journal of medical microbiology, 2012, Vitali, Luca A et. al.
Antitoxins: therapy for stressed bacteria.
score: 0.29252647, Nature chemical biology, 2011, Hadjifrangiskou, Maria; Kostakioti, Maria; Hultgren, Scott J
Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors
score: 0.29194873, Bioorganic & Medicinal Chemistry, 1995, Beeley, Lee J. et. al.
The 2′-OH group at the group II intron terminus acts as a proton shuttle
score: 0.29157418, Nature chemical biology, 2009, Roitzsch, Michael; Fedorova, Olga; Pyle, Anna Marie
3D QSAR comparative molecular field analysis on nonsteroidal farnesoid X receptor activators
score: 0.29131366, Journal of Molecular Graphics and Modelling, 2007, Honório, Káthia M. et. al.
Solution conformations of KNI-272, a tripeptide HIV protease inhibitor designed on the basis of substrate transition state: Determined by NMR spectroscopy and simulated annealing calculations
score: 0.29082299, Bioorganic & Medicinal Chemistry, 1996, Ohno, Yasushi; Kiso, Yoshiaki; Kobayashi, Yuji
Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.
score: 0.29072891, Molecular pharmacology, 2011, Schepetkin, Igor A et. al.
Peptidase Substrates via Global Peptide Profiling
score: 0.29055267, Nature chemical biology, 2008, Tagore, Debarati M. et. al.
Pharmacophore modeling and virtual screening studies to design potential COMT inhibitors as new leads
score: 0.29042539, Journal of Molecular Graphics and Modelling, 2013, Jatana, Nidhi; Sharma, Aditya; Latha, N.
Pharmacophore modeling and virtual screening studies to design potential COMT inhibitors as new leads
score: 0.29042539, Journal of Molecular Graphics and Modelling, 2013, Jatana, Nidhi; Sharma, Aditya; Latha, N.
Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase.
score: 0.29028316, Nature chemical biology, 2008, Bandarian, Vahe
Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease
score: 0.29027363, Journal of Molecular Graphics and Modelling, 2006, da Silva, Carlos H.T.P. et. al.
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.
score: 0.29025172, Proceedings of the National Academy of Sciences of the United States of America, 2008, Cavazzuti, Antonio et. al.
New lanthanide complexes of 4-methyl-7-hydroxycoumarin and their pharmacological activity
score: 0.28914162, European Journal of Medicinal Chemistry, 2001, Kostova, Irena et. al.
The physical chemistry of biological membranes.
score: 0.28897002, Nature chemical biology, 2006, Zimmerberg, Joshua; Gawrisch, Klaus
A windfall for RNA.
score: 0.2888989, Nature chemical biology, 2007,
Synthesis, herbicidal activities and comparative molecular field analysis study of some novel triazolinone derivatives.
score: 0.28875005, Chemical biology & drug design, 2009, Wang, Lei et. al.
Crosslinking of imprinted proteases to maintain a tailor-made substrate selectivity in aqueous solutions
score: 0.28863826, Bioorganic & Medicinal Chemistry, 1999, Peißker, Fabian; Fischer, Lutz
Facile synthesis of a new type of iminosugar: a nitrogen atom is in the anomeric position
score: 0.28836934, Bioorganic & Medicinal Chemistry, 1995, Ichikawa, Mie; Ichikawa, Yoshitaka
Design, synthesis and structural studies of meta -xylyl linked bis -benzimidazolium salts: potential anticancer agents against ‘human colon cancer’
score: 0.28765386, Chemistry Central Journal, 2012, Haque, Rosenani A et. al.
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited.
score: 0.28714567, Nature chemical biology, 2006, English, Brian P et. al.
Appraisal of a glycopeptide cloaking strategy for a therapeutic oligopeptide: Glycopeptide analogs of the renin inhibitor ditekiren
score: 0.28699223, Bioorganic & Medicinal Chemistry, 1994, Harrison, Allen W. et. al.
Glycome 'fingerprints' provide definitive clues to HIV origins.
score: 0.28607246, Nature chemical biology, 2009, Hirabayashi, Jun
2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors
score: 0.28597686, Bioorganic & Medicinal Chemistry, 2002, Johansen, Tommy N. et. al.
Partial resistance of E. coli mutants against 2,4-diamino-5-benzylpyrimidines by interactions with bacterial membrane lipopolysaccharides. Derivation of quantitative structure–binding relationships
score: 0.28588971, European Journal of Medicinal Chemistry, 2000, Schop, Heinrich et. al.
Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols
score: 0.28565535, Malaria Journal, 2010, Milner, Erin et. al.
Design, synthesis, and biological evaluation of isocyanurate-based antifungal and macrolide antibiotic conjugates: Iron transport-mediated drug delivery
score: 0.28552775, Bioorganic & Medicinal Chemistry, 1995, Ghosh, Manuka; Miller, Marvin J.
Stem cells: chemically reprogramming cell fates.
score: 0.28550673, Nature chemical biology, 2010, Ellis, Ronald E
A bacterial copper metallothionein.
score: 0.28525069, Nature chemical biology, 2008, Robinson, Nigel J
Eyes wide open.
score: 0.28492321, Nature chemical biology, 2009,
Those who can teach, should.
score: 0.28478596, Nature chemical biology, 2007,
The ins and outs of cells.
score: 0.28478596, Nature chemical biology, 2011,
Interrupters on the bacterial party line.
score: 0.28478596, Nature chemical biology, 2005, Novick, Richard P
A large-scale protein-function database.
score: 0.28478596, Nature chemical biology, 2010, Apweiler, Rolf et. al.
Carbohydrates: Cracking the glycan sequence code.
score: 0.28478596, Nature chemical biology, 2011, Jones, Christopher J; Larive, Cynthia K
Rights for students expanding.
score: 0.28478596, Nature chemical biology, 2006,
Biochemical networks: the evolution of gene annotation.
score: 0.28478596, Nature chemical biology, 2010, Kasif, Simon; Steffen, Martin
Walking the walk.
score: 0.28478596, Nature chemical biology, 2006,
A new procedure for the labeling of peptides and amino acids
score: 0.28402585, Bioorganic & Medicinal Chemistry, 1995, Barton, Derek H.R. et. al.
Expanding the range of ‘druggable’ targets with natural product-based libraries: an academic perspective
score: 0.28401493, Current Opinion in Chemical Biology, 2010, Bauer, Renato A; Wurst, Jacqueline M; Tan, Derek S
Berkeley center for synthetic biology.
score: 0.2839942, Nature chemical biology, 2007, Bucci, Mirella
Absolute Metabolite Concentrations and Implied Enzyme Active Site Occupancy in Escherichia coli
score: 0.28376636, Nature chemical biology, 2009, Bennett, Bryson D et. al.
Understanding DNA-based catalysis one molecule at a time.
score: 0.28355344, Nature chemical biology, 2007, Schlosser, Kenny; Li, Yingfu
Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling.
score: 0.28307706, Nature chemical biology, 2006, Ile, Kristina E; Schaaf, Gabriel; Bankaitis, Vytas A
Talking microbes.
score: 0.2827632, Nature chemical biology, 2012,
Mechanical modulation of catalytic power on F(1)-ATPase.
score: 0.28241701, Nature chemical biology, 2011, Watanabe, Rikiya et. al.
A direct NMR method for the measurement of competitive kinetic isotope effects.
score: 0.28211507, Nature chemical biology, 2010, Chan, Jefferson et. al.
Inhibition of human immunodeficiency virus integrase by bis-catechols.
score: 0.28153186, Antimicrobial agents and chemotherapy, 1995, LaFemina, R L et. al.
Iron-sulfur clusters as oxygen-responsive molecular switches.
score: 0.2814668, Nature chemical biology, 2007, Outten, F Wayne
Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I
score: 0.28134398, Bioorganic & Medicinal Chemistry, 1994, Wang, Hui-Kang et. al.
H-NS gives invading DNA the silent treatment.
score: 0.281249, Nature chemical biology, 2006, Pflum, Mary Kay H
Peptidase substrates via global peptide profiling.
score: 0.28077105, Nature chemical biology, 2009, Tagore, Debarati M et. al.
Ion channels: Cooperativity in twin gatings.
score: 0.28067498, Nature chemical biology, 2012, Zhou, Lei
Synthesis, molecular modelling, and NMR structure determination of four cyclic peptide antagonists of endothelin
score: 0.28045001, Bioorganic & Medicinal Chemistry, 1994, Bradley, Erin K. et. al.
6 5-HT 2C Ligands: Recent Progress
score: 0.28032687, Progress in Medicinal Chemistry, 2008, Monck, Nathaniel J.T.; Kennett, Guy A.
6-Arylamino-5,8-quinazolinediones as potent inhibitors of endothelium-dependent vasorelaxation
score: 0.28020675, European Journal of Medicinal Chemistry, 2002, Ryu, Chung-Kyu; Shin, Keun-Hwa; Seo, Ji-Hui; Kim, Hwa-Jung
Synthesis and antibacterial activity of some 5-guanylhydrazone/thiocyanato-6-arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide derivatives †
score: 0.28013029, European Journal of Medicinal Chemistry, 2000, Gadad, Andanappa K et. al.
Synthesis of some thieno gamma lactam monocarboxylic acids with high antibacterial activity: A new look at an old molecular system
score: 0.27985106, Bioorganic & Medicinal Chemistry, 1998, Kar, Gandhi K. et. al.
Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase
score: 0.27885748, PLoS ONE, 2010, Durk, Ryan C. et. al.
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors.
score: 0.27879945, Antimicrobial agents and chemotherapy, 1996, Rosenthal, P J et. al.
Biosynthesis: A new (old) way of hijacking tRNA.
score: 0.27876339, Nature chemical biology, 2010, Lahoud, Georges; Hou, Ya-Ming
Creating communities.
score: 0.27872554, Nature chemical biology, 2009,
OTU takes the chains OUT.
score: 0.27853788, Nature chemical biology, 2008, Balakirev, Maxim Y; Wilkinson, Keith D
Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/NMPRTase for glioma therapy
score: 0.27797849, Journal of Clinical Bioinformatics, 2011, Chandra, Nagasuma et. al.
Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template
score: 0.27785567, PPAR Research, 2008, Miyachi, Hiroyuki; Hashimoto, Yuichi
Molecule by molecule, the physics and chemistry of life: SMB 2007.
score: 0.27784462, Nature chemical biology, 2007, Block, Steven M et. al.
Emergent bistability by a growth-modulating positive feedback circuit.
score: 0.27764352, Nature chemical biology, 2009, Tan, Cheemeng; Marguet, Philippe; You, Lingchong
Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition
score: 0.27762129, Pharmacological Research, 2013, Roskoski, Robert
Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids.
score: 0.27760935, Acta pharmacologica Sinica, 2009, Zhu, Yi-Ping et. al.
Applications of random sampling to virtual screening of combinatorial libraries
score: 0.27745526, Journal of Molecular Graphics and Modelling, 2000, Beroza, Paul et. al.
Redox sensing and histidine oxidation: no longer PerR-fect strangers.
score: 0.27694689, Nature chemical biology, 2006, Moye-Rowley, W Scott
A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation
score: 0.27668418, Nature chemical biology, 2010, Schwarz, Flavio et. al.
Ion channels get flashy.
score: 0.27661903, Nature chemical biology, 2006, Bayley, Hagan
Radiosynthesis and pharmacological evaluation of [ 11C]EMD-95885: a high affinity ligand for NR2B-containing NMDA receptors
score: 0.27639976, Bioorganic & Medicinal Chemistry, 2004, Roger, G et. al.
Electro-chemical coupling in the voltage-dependent phosphatase Ci-VSP
score: 0.27621096, Nature chemical biology, 2010, Kohout, Susy C. et. al.
Synthesis of a glycopeptide carrying a N-linked core pentasaccharide
score: 0.27591548, Bioorganic & Medicinal Chemistry, 1995, Matsuo, Ichiro et. al.
Anticoccidial activities of 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine and other alpha 2 adrenergic agonists.
score: 0.27547284, Antimicrobial agents and chemotherapy, 1992, McFarland, J W et. al.
A mechanistic meeting point.
score: 0.27500434, Nature chemical biology, 2007,
Assigning responsibility and credit.
score: 0.27500434, Nature chemical biology, 2009,
Compelling comments.
score: 0.27469133, Nature chemical biology, 2011,
Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase.
score: 0.27436615, ChemMedChem, 2008, Tipparaju, Suresh K et. al.
Assembling the pieces.
score: 0.27418215, Nature chemical biology, 2011,
A practical approach to docking of zinc metalloproteinase inhibitors
score: 0.2741786, Journal of Molecular Graphics and Modelling, 2004, Hu, Xin; Balaz, Stefan; Shelver, William H
Plant signaling: Deconstructing auxin sensing.
score: 0.27413066, Nature chemical biology, 2012, Vanneste, Steffen; Friml, Jiří
Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.
score: 0.27391133, Proceedings of the National Academy of Sciences of the United States of America, 2010, Marjanovic, Jasmina et. al.
Prodrug strategies to overcome poor water solubility
score: 0.27386866, Advanced Drug Delivery Reviews, 2007, Stella, Valentino J.; Nti-Addae, Kwame W.
Neurodegeneration: Recall sugars, forget Alzheimer's.
score: 0.27382833, Nature chemical biology, 2012, Lefebvre, Tony
Neural stem cells, acetylcholine and Alzheimer's disease.
score: 0.27337548, Nature chemical biology, 2007, Fullwood, Nigel J
Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase.
score: 0.27299774, Nature chemical biology, 2011, Köksal, Mustafa et. al.
In silico toxicology for the pharmaceutical sciences
score: 0.27202952, Toxicology and Applied Pharmacology, 2009, Valerio, Luis G.
Regulation of Nuclear PKA revealed by spatiotemporal manipulation of cAMP
score: 0.27190844, Nature chemical biology, 2011, Sample, Vedangi et. al.
Mussel protein adhesion depends on thiol-mediated redox modulation
score: 0.27190219, Nature chemical biology, 2011, Yu, Jing et. al.
Integration of fragment screening and library design
score: 0.27182635, Drug Discovery Today, 2007, Siegal, Gregg; AB, Eiso; Schultz, Jan
Tyrosine Kinase Syk Non-Enzymatic Inhibitors and Potential Anti-Allergic Drug-Like Compounds Discovered by Virtual and In Vitro Screening
score: 0.27174342, PLoS ONE, 2011, Villoutreix, Bruno O. et. al.
The proteasome makes sense of mixed signals.
score: 0.27169404, Nature chemical biology, 2009, Wandless, Thomas J
Fighting toxic copper in a bacterial pathogen.
score: 0.2716179, Nature chemical biology, 2007, Wilmot, Carrie M
Ethambutol–sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis
score: 0.27153139, Carbohydrate Research, 1999, Reynolds, Robert C et. al.
Fluorescent timers shine a light on protein trafficking.
score: 0.2714796, Nature chemical biology, 2009, Dikici, Emre; Daunert, Sylvia
SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase.
score: 0.27134865, IUBMB life, 2010, Kumar, Gyanendra et. al.
Emerging glycomics technologies.
score: 0.2710678, Nature chemical biology, 2007, Turnbull, Jeremy E; Field, Robert A
Dynamic O -GlcNAc Modification Regulates CREB-Mediated Gene Expression and Memory Formation
score: 0.27097149, Nature Chemical Biology, 2011, Rexach, Jessica E. et. al.
Designed four-helix bundle catalysts—the engineering of reactive sites for hydrolysis and transesterification reactions of p-nitrophenyl esters
score: 0.27086615, Bioorganic & Medicinal Chemistry, 1999, Baltzer, Lars et. al.
Chemical ecology: Reprogramming a termite monarchy.
score: 0.2704424, Nature chemical biology, 2010, Bussell, Jennifer J; Vosshall, Leslie B
Three-component synthesis of pyrano[2,3- d ]-pyrimidine dione derivatives facilitated by sulfonic acid nanoporous silica (SBA-Pr-SO 3 H) and their docking and urease inhibitory activity
score: 0.27022614, DARU Journal of Pharmaceutical Sciences, 2013, Ziarani, Ghodsi Mohammadi et. al.
Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity
score: 0.26976581, European Journal of Medicinal Chemistry, 2000, Turan-Zitouni, Gülhan et. al.
Interaction of benzopyranone derivatives and related compounds with human concentrative nucleoside transporters 1, 2 and 3 heterologously expressed in porcine PK15 nucleoside transporter deficient cells. Structure–activity relationships and determinants of transporter affinity and selectivity
score: 0.26919505, Biochemical Pharmacology, 2010, Wang, Chunmei; Pimple, Surekha; Buolamwini, John K.
Imaging: Visualizing a neuronal handshake.
score: 0.26898789, Nature chemical biology, 2010, Miyawaki, Atsushi
New isoxazole derivatives designed as nicotinic acetylcholine receptor ligand candidates
score: 0.26894655, European Journal of Medicinal Chemistry, 2002, Silva, Nilda M et. al.
Sensing nutrient levels in bacteria.
score: 0.26850242, Nature chemical biology, 2007, Ferenci, Thomas
Direct transfer of membrane proteins from bacteria to planar bilayers for rapid screening by single-channel recording.
score: 0.26844262, Nature chemical biology, 2006, Holden, Matthew A et. al.
Using transcriptome sequencing to identify mechanisms of drug action and resistance
score: 0.2683315, Nature chemical biology, 2011, Wacker, Sarah A. et. al.
Thrombin active site inhibitors
score: 0.26806835, Bioorganic & Medicinal Chemistry, 1995, Das, Jagabandhu; David Kimball, S.
Protein folding: sticky N17 speeds huntingtin pile-up.
score: 0.26799756, Nature chemical biology, 2010, Liebman, Susan W; Meredith, Stephen C
Structure-based design of novel pyrimido[4,5-c]pyridazine derivatives as dihydropteroate synthase inhibitors with increased affinity.
score: 0.26787246, ChemMedChem, 2012, Zhao, Ying et. al.
An alternate synthesis of the tat-antagonist 7-chloro- N-methyl-5-(1 H-pyrrol-2-yl)-3 H-1,4-benzodiazepin-2-amine
score: 0.26782005, Bioorganic & Medicinal Chemistry, 1995, Maehr, Hubert; Zenchoff, Gladys; Coffen, David L.
Progressive ordering with decreasing temperature of the phospholipids of influenza virus.
score: 0.26762252, Nature chemical biology, 2008, Polozov, Ivan V et. al.
Histone H2B ubiquitylation disrupts local and higher order chromatin compaction
score: 0.26734072, Nature chemical biology, 2010, Fierz, Beat et. al.
Integrated Dataset of Screening Hits against Multiple Neglected Disease Pathogens
score: 0.26730363, PLoS Neglected Tropical Diseases, 2011, Nwaka, Solomon et. al.
Indolocarbazole protein kinase C inhibitors from rebeccamycin
score: 0.2671947, Bioorganic & Medicinal Chemistry, 1994, Fabre, Serge et. al.
MS-271, a novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp.—I. isolation, structural determination and biological properties of MS-271
score: 0.26719326, Bioorganic & Medicinal Chemistry, 1996, Yano, Keiichi et. al.
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.
score: 0.26696461, Nature chemical biology, 2010, Teo, Chin Fen et. al.
Spherical Harmonics Coefficients for Ligand-Based Virtual Screening of Cyclooxygenase Inhibitors
score: 0.26660381, PLoS ONE, 2011, Wang, Quan et. al.
QSAR, docking and in-vivo studies for Immunomodulatory activity of isolated triterpenoids from Eucalyptus tereticornis and Gentiana kurroo
score: 0.26652304, European Journal of Pharmaceutical Sciences, 2012, Maurya, Anupam et. al.
Conformational study of 2-phenylbenzothiazine part of SA2995, a Ca 2+ antagonist having a benzothiazine skeleton, and structure-activity relationships
score: 0.26622572, Bioorganic & Medicinal Chemistry, 1994, Fujimura, Ken-ichi et. al.
Histone deacetylation: IP4 is an epigenetic coregulator.
score: 0.26619481, Nature chemical biology, 2012, Kutateladze, Tatiana G
The English patients.
score: 0.26614925, Nature chemical biology, 2006,
Microbiology: tuning communication fidelity.
score: 0.26614925, Nature chemical biology, 2011, Jung, Kirsten
N-substituted aminomethanephosphonic and aminomethane- P -methylphosphinic acids as inhibitors of ureases
score: 0.26600019, Amino Acids, 2011, Berlicki, Łukasz et. al.
Reduction of N-hydroxy-sulfonamides, including N-hydroxy-valdecoxib, by the molybdenum-containing enzyme mARC.
score: 0.26592264, Drug metabolism and disposition: the biological fate of chemicals, 2010, Havemeyer, Antje et. al.
Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A
score: 0.26565347, PLoS ONE, 2007, Tang, Jing et. al.
3Recent Progress Toward Nonpeptide Ligands for the Melanocortin-4 Receptor
score: 0.26560519, Progress in Medicinal Chemistry, 2007, Chen, Chen
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
score: 0.26543978, Proceedings of the National Academy of Sciences of the United States of America, 2009, Biggadike, Keith et. al.
Post-reductionist protein science, or putting Humpty Dumpty back together again.
score: 0.26529347, Nature chemical biology, 2009, Gierasch, Lila M; Gershenson, Anne
Synthesis of hexahydrocyclopentimidazol-2-(1 H)-one derivatives displaying selective DP-receptor agonist properties
score: 0.26528119, Bioorganic & Medicinal Chemistry, 1996, Barraclough, Paul et. al.
Arresting malaria parasite egress from infected red blood cells.
score: 0.26527424, Nature chemical biology, 2008, Lee, Marcus C S; Fidock, David A
Transcriptional activation by small RNA duplexes.
score: 0.264363, Nature chemical biology, 2007, Rossi, John J
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination
score: 0.2643269, Nature chemical biology, 2012, Zeng, Xing; King, Randall W.
Allosteric modulation of adenosine receptors
score: 0.26428661, Purinergic Signalling, 2008, Göblyös, Anikó; IJzerman, Ad P.
Aptamers for allosteric regulation.
score: 0.26393396, Nature chemical biology, 2011, Vinkenborg, Jan L; Karnowski, Nora; Famulok, Michael
Cooperativity in macromolecular assembly.
score: 0.26359033, Nature chemical biology, 2008, Williamson, James R
Stopping malaria parasites dead in their tracks.
score: 0.26294185, Nature chemical biology, 2008, Doerig, Christian D
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
score: 0.26283524, Proceedings of the National Academy of Sciences of the United States of America, 2008, Boeckler, Frank M et. al.
Probing cell death by chemical screening.
score: 0.26268177, Nature chemical biology, 2005, Wallach, David
Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?
score: 0.26246841, Life Sciences, 2010, Filizola, Marta
Enzymatic catalysis on conducting graphite particles.
score: 0.2623821, Nature chemical biology, 2007, Vincent, Kylie A et. al.
How curved membranes recruit amphipathic helices and protein anchoring motifs.
score: 0.26234135, Nature chemical biology, 2009, Hatzakis, Nikos S et. al.
Translating metabolic exchange with imaging mass spectrometry
score: 0.26211654, Nature chemical biology, 2009, Yang, Yu-Liang et. al.
Biosynthesis: unmasking morphine.
score: 0.26113209, Nature chemical biology, 2010, Dimise, Eric J; Bruner, Steven D
Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles
score: 0.26102555, European Journal of Medicinal Chemistry, 2001, Lukevics, Edmunds et. al.
Synthetic biology: an RNP switch raises a roadblock.
score: 0.2605005, Nature chemical biology, 2010, Ferré-D'Amaré, Adrian R
Molecular Modeling Studies of 4,5-Dihydro-1 H -pyrazolo[4,3- h ] quinazoline Derivatives as Potent CDK2/Cyclin A Inhibitors Using 3D-QSAR and Docking
score: 0.26030548, International Journal of Molecular Sciences, 2010, Ai, Yong; Wang, Shao-Teng; Sun, Ping-Hua; Song, Fa-Jun
Design of focused and restrained subsets from extremely large virtual libraries
score: 0.26007867, Journal of Molecular Graphics and Modelling, 2003, Jamois, Eric A; Lin, Chien T; Waldman, Marvin
Metabolic oxidation regulates embryonic stem cell differentiation
score: 0.25925524, Nature chemical biology, 2010, Yanes, Oscar et. al.
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome
score: 0.25890723, Nature chemical biology, 2009, Manosas, Maria et. al.
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.
score: 0.25887041, Nature chemical biology, 2010, Kohout, Susy C et. al.
The evolving role of natural products in drug discovery.
score: 0.2586835, Nature reviews. Drug discovery, 2005, Koehn, Frank E; Carter, Guy T
3D-QSAR study of corticotropin-releasing factor 1 antagonists and pharmacophore-based drug design
score: 0.25808134, Neurochemistry International, 2010, Ye, Yingda; Liao, Qinghua; Wei, Jing; Gao, Qingzhi
Rational design of high affinity tachykinin NK 2 receptor antagonists
score: 0.25788186, Bioorganic & Medicinal Chemistry, 1994, Boyle, S. et. al.
Metallo-β-lactamases withstand low Zn II conditions by tuning metal-ligand interactions
score: 0.25772226, Nature chemical biology, 2012, González, Javier M. et. al.
The end defines the means in bacterial mRNA decay.
score: 0.25747261, Nature chemical biology, 2007, Schoenberg, Daniel R
Quantitation of O -Glycosylation Stoichiometry and Dynamics using Resolvable Mass Tags
score: 0.25734551, Nature chemical biology, 2010, Rexach, Jessica E. et. al.
Chemometric QSAR Modeling and In Silico Design of Antioxidant NO Donor Phenols
score: 0.25730404, Scientia Pharmaceutica, 2010, Mitra, Indrani; Saha, Achintya; Roy, Kunal
Acting together, bacterial clusters initiate coagulation.
score: 0.25712797, Nature chemical biology, 2008, Borenstein, Jeffrey T
Structure and Mechanism of the Diterpene Cyclase ent -Copalyl Diphosphate Synthase
score: 0.25688826, Nature chemical biology, 2011, Köksal, Mustafa et. al.
Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication.
score: 0.25638196, ChemMedChem, 2012, Ali, Akbar et. al.
A causative link between the structure of aberrant protein oligomers and their toxicity.
score: 0.2561882, Nature chemical biology, 2010, Campioni, Silvia et. al.
Combinatorial synthesis of carbohydrates
score: 0.25582447, Current Opinion in Chemical Biology, 1999, Schweizer, Frank; Hindsgaul, Ole
Application of data mining approaches to drug delivery
score: 0.25558911, Advanced Drug Delivery Reviews, 2006, Ekins, Sean; Shimada, Jun; Chang, Cheng
Sugars stack up.
score: 0.25548938, Nature chemical biology, 2008, Tatko, Chad
Structural functions of antimicrobial long-chain alcohols and phenols
score: 0.25548423, Bioorganic & Medicinal Chemistry, 1995, Kubo, Isao; Muroi, Hisae; Kubo, Aya
Design of new small cyclic melanocortin receptor-binding peptides using molecular modelling: Role of the His residue in the melanocortin peptide core
score: 0.25509376, European Journal of Medicinal Chemistry, 2001, Prusis, Peteris et. al.
Antitoxin MqsA Helps Mediate the Bacterial General Stress Response
score: 0.25507726, Nature chemical biology, 2011, Wang, Xiaoxue et. al.
Novel designed enediynes: Molecular design, chemical synthesis, mode of cycloaromatization and guanine-specific DNA cleavage
score: 0.25506127, Bioorganic & Medicinal Chemistry, 1996, Toshima, Kazunobu et. al.
Intracellular zinc irritates TRPA1.
score: 0.25504113, Nature chemical biology, 2009, Banke, Tue G; Wickenden, Alan D
Regulation of apoptosis in leukemic cells by analogs of dynemicin A
score: 0.25484873, Bioorganic & Medicinal Chemistry, 1994, Hiatt, Andrew et. al.
SAS-6 oligomerization: the key to the centriole?
score: 0.25425253, Nature chemical biology, 2011, Cottee, Matthew A et. al.
Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy
score: 0.25396604, Chinese Medicine, 2011, Mimeault, Murielle; Batra, Surinder K
Pharmacophore identification, docking and “in silico” screening for novel CDK1 inhibitors
score: 0.25345118, Journal of Molecular Graphics and Modelling, 2012, Dong, Xiaowu et. al.
Pharmacophore identification, docking and “in silico” screening for novel CDK1 inhibitors
score: 0.25345118, Journal of Molecular Graphics and Modelling, 2012, Dong, Xiaowu et. al.
Pharmacophore identification, docking and “in silico” screening for novel CDK1 inhibitors
score: 0.25345118, Journal of Molecular Graphics and Modelling, 2012, Dong, Xiaowu et. al.
Signaling-Mediated Bacterial Persister Formation
score: 0.2534484, Nature chemical biology, 2011, Vega, Nicole M. et. al.
Symbiotic Streptomycetes provide antibiotic combination prophylaxis for wasp offspring.
score: 0.25334538, Nature chemical biology, 2010, Kroiss, Johannes et. al.
Design of orally bioavailable, symmetry-based inhibitors of HIV protease
score: 0.2533075, Bioorganic & Medicinal Chemistry, 1994, Kempf, Dale J. et. al.
Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice.
score: 0.25330169, Nature chemical biology, 2011, Cahalan, Stuart M et. al.
Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)
score: 0.25296057, Nuclear Medicine and Biology, 2007, Kil, Kun-Eek et. al.
Dynamic refolding of IFN-gamma mRNA enables it to function as PKR activator and translation template.
score: 0.25249451, Nature chemical biology, 2009, Cohen-Chalamish, Smadar et. al.
New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT 1A serotonin receptors and serotonin transporter as a new class of antidepressants
score: 0.25236731, European Journal of Medicinal Chemistry, 2001, Martı́nez, Javier et. al.
Discovery of a Novel Family of CDK Inhibitors with the Program LIDAEUS
score: 0.25178162, Structure, 2003, Wu, Su Ying et. al.
Robust processivity of myosin V under off-axis loads.
score: 0.25148163, Nature chemical biology, 2010, Oguchi, Yusuke et. al.
Antigene leaps forward through an open door.
score: 0.25101879, Nature chemical biology, 2005, Armitage, Bruce A
Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
score: 0.25069438, Molecular pharmacology, 2007, Lemaire, Géraldine et. al.
Phosphate release in F1-ATPase catalytic cycle follows ADP release.
score: 0.24994311, Nature chemical biology, 2010, Watanabe, Rikiya; Iino, Ryota; Noji, Hiroyuki
Slicer and the argonautes.
score: 0.24983021, Nature chemical biology, 2007, Tolia, Niraj H; Joshua-Tor, Leemor
Computational proteomics of biomolecular interactions in the sequence and structure space of the tyrosine kinome: deciphering the molecular basis of the kinase inhibitors selectivity.
score: 0.24962823, Proteins, 2007, Verkhivker, Gennady M
In vitro and in vivo antibacterial activities of CS-834, a novel oral carbapenem.
score: 0.24958937, Antimicrobial agents and chemotherapy, 1997, Fukuoka, T et. al.
Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrilesas Selective, Orally Bioavailable CHK1 Inhibitors
score: 0.24920014, Journal of Medicinal Chemistry, 2012, Lainchbury, Michael et. al.
Enzymatic peptide synthesis in low water content systems: Preparative enzymatic synthesis of [Leu]- and [Met]-enkephalin derivatives
score: 0.24906958, Bioorganic & Medicinal Chemistry, 1995, Clapés, Pere; Torres, Josep-Lluis; Adlercreutz, Patrick
A carbohydrate vaccine exceeds the sum of its parts.
score: 0.24873088, Nature chemical biology, 2007, Bundle, David R
Generation of an aromatic amide-derived phosphane (Aphos) library by self-assisted molecular editing and applications of Aphos in room-temperature Suzuki-Miyaura reactions.
score: 0.24864867, Chemistry (Weinheim an der Bergstrasse, Germany), 2008, Dai, Wei-Min et. al.
Inhibition of Helicobacter pylori Urease by Phenyl Phosphorodiamidates: Mechanism of Action
score: 0.24863916, Bioorganic & Medicinal Chemistry, 1995, Faraci, W.Stephen et. al.
Studies on the Reactivity of (9-Methyl-5,6-dihydronaphtho[1′,2′:4,5]-thieno[2,3- d ]pyrimidin-11-yl)hydrazine Towards Some Reagents for Biological Evaluation
score: 0.24829212, Scientia Pharmaceutica, 2009, Rashad, Aymn E. et. al.
Chronicles of the GTPase switch.
score: 0.24822429, Nature chemical biology, 2011, Cherfils, Jacqueline; Zeghouf, Mahel
Targeted antioxidant delivery prolongs sperm lifespan.
score: 0.24755964, Nature chemical biology, 2005, Donnelly, Eilish T
Anti-AIDS agents—XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: Isolation and structural elucidation
score: 0.24702732, Bioorganic & Medicinal Chemistry, 1995, Chen, Ke et. al.
Ala scan analogues of HOE 140. Synthesis and biological activities
score: 0.246661, European Journal of Medicinal Chemistry, 2000, Quartara, Laura et. al.
Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors
score: 0.24658372, Journal of Molecular Graphics and Modelling, 2006, Milac, Adina-Luminiţa et. al.
Array methodology singles out pathogenic bacteria.
score: 0.2462725, Nature chemical biology, 2006, Pohl, Nicola L
Structural Requirements of N-Substituted Spiropiperidine Analogues as Agonists of Nociceptin/Orphanin FQ Receptor
score: 0.24616772, International Journal of Molecular Sciences, 2011, Bao, Pingping et. al.
Phase behavior of lipid mixtures.
score: 0.24558812, Nature chemical biology, 2006, Feigenson, Gerald W
Actions of a picomolar short-acting S1P 1 agonist in S1P 1 -eGFP knock-in mice
score: 0.2453512, Nature chemical biology, 2011, Cahalan, Stuart M. et. al.
Facing the challenges of Cu, Fe and Zn homeostasis in plants.
score: 0.2448229, Nature chemical biology, 2009, Palmer, Christine M; Guerinot, Mary Lou
Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents
score: 0.24461579, PLoS ONE, 2011, Drwal, Malgorzata N. et. al.
A molecular basis for NO selectivity in soluble guanylate cyclase.
score: 0.24422369, Nature chemical biology, 2005, Boon, Elizabeth M; Huang, Shirley H; Marletta, Michael A
Silyl protection in the solid-phase synthesis of N-linked glycopeptides. Preparation of glycosylated fluorogenic substrates for subtilisins
score: 0.24391187, Bioorganic & Medicinal Chemistry, 1994, Christiansen-Brams, Ida et. al.
Replication dependent instability at (CTG)•(CAG) repeat hairpins in human cells
score: 0.24352991, Nature chemical biology, 2010, Liu, Guoqi et. al.
A library of RNA bridges.
score: 0.24351186, Nature chemical biology, 2006, Gao, Ning; Frank, Joachim
Meetings of the minds.
score: 0.24349619, Nature chemical biology, 2005,
On citing well.
score: 0.24318317, Nature chemical biology, 2010,
QSAR studies on a number of pyrrolidin-2-one antiarrhythmic arylpiperazinyls
score: 0.24316313, Medicinal Chemistry Research, 2011, Nowaczyk, Alicja; Kulig, Katarzyna
Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA
score: 0.24206301, Bioorganic & Medicinal Chemistry, 1994, Sakurai, Mitsuya et. al.
Substrate selection by the proteasome during degradation of protein complexes
score: 0.24192296, Nature chemical biology, 2008, Prakash, Sumit et. al.
Drug design for ever, from hype to hope
score: 0.2409064, Journal of Computer-Aided Molecular Design, 2012, Seddon, G. et. al.
The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA
score: 0.2407485, Nature chemical biology, 2009, Kelly, Robert C. et. al.
Automatic policing of biochemical annotations using genomic correlations
score: 0.2406588, Nature chemical biology, 2009, Hsiao, Tzu-Lin et. al.
Endoplasmic Reticulum Ca 2+ Increases Enhance Mutant Glucocerebrosidase Proteostasis
score: 0.2392944, Nature chemical biology, 2010, Ong, Derrick Sek Tong et. al.
A non-ionic water-soluble pentaphyrin derivative. Synthesis and cytotoxicity
score: 0.23924893, Bioorganic & Medicinal Chemistry, 1995, Král, Vladimír et. al.
Ribonucleic general acid.
score: 0.2383715, Nature chemical biology, 2005, Strobel, Scott A
COX-2's new role in inflammation.
score: 0.23820445, Nature chemical biology, 2010, Chen, Chu
Zinc activates damage-sensing TRPA1 ion channels.
score: 0.23786678, Nature chemical biology, 2009, Hu, Hongzhen et. al.
Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds
score: 0.23767615, European Journal of Medicinal Chemistry, 2002, Dimmock, Jonathan R et. al.
Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents
score: 0.23744446, European Journal of Medicinal Chemistry, 2002, Klimešová, Věra et. al.
PhDD: A new pharmacophore-based de novo design method of drug-like molecules combined with assessment of synthetic accessibility
score: 0.23679526, Journal of Molecular Graphics and Modelling, 2010, Huang, Qi; Li, Lin-Li; Yang, Sheng-Yong
Antiviral effect of phosphorothioate oligodeoxyribonucleotides complementary to human immunodeficiency virus
score: 0.2364058, Bioorganic & Medicinal Chemistry, 1995, Kim, Sang-Gug et. al.
Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation.
score: 0.23624755, Nature chemical biology, 2012, Rexach, Jessica E et. al.
A proton-controlled check valve for sodium ion transport.
score: 0.23584271, Nature chemical biology, 2007, Roux, Benoît
Pharmacophore Identification, Docking and “In silico” Screening for Novel CDK1 Inhibitors
score: 0.23554837, Journal of Molecular Graphics and Modelling, 2012, Dong, Xiaowu et. al.
Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.
score: 0.23548304, Antimicrobial agents and chemotherapy, 1995, Gakunju, D M et. al.
High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists.
score: 0.23528214, Molecular pharmacology, 2007, Schepetkin, Igor A et. al.
Viral RNA gymnastics.
score: 0.23498186, Nature chemical biology, 2005, Calabro, Valerie; Frankel, Alan D
Reconciling the chemistry and biology of reactive oxygen species.
score: 0.23496645, Nature chemical biology, 2008, Winterbourn, Christine C
A new affinity ligand for the isolation of a single ‘feruloyl esterase’ (FAE-III) from Aspergillus niger
score: 0.23487079, Bioorganic & Medicinal Chemistry, 2000, Zhao, Yongxin; Sinnott, Michael L.
Cross-pollinating fields.
score: 0.2346878, Nature chemical biology, 2009,
Chaperones: A story of thrift unfolds.
score: 0.23371999, Nature chemical biology, 2010, Baneyx, François; Nannenga, Brent L
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease
score: 0.23363463, Analytical Biochemistry, 2009, Bodenreider, Christophe et. al.
Continuous evolution: protein evolution at warp speed.
score: 0.2336082, Nature chemical biology, 2011, Lehman, Niles
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis
score: 0.23325472, Nature Chemical Biology, 2011, Verrier, Florence et. al.
Synthesis of mannostatins A and B from myo-inositol
score: 0.23260768, Bioorganic & Medicinal Chemistry, 1995, Ogawa, Seiichiro; Yuming, Yu
Pulling out the coordination mechanism of myosin-VI.
score: 0.23144742, Nature chemical biology, 2009, Lindén, Martin
Synthesis of N-glyoxylyl peptides and their in vitro evaluation as HIV-1 protease inhibitors
score: 0.23122502, Bioorganic & Medicinal Chemistry, 1997, Qasmi, Driss et. al.
Auxin and other signals on the move in plants.
score: 0.23101353, Nature chemical biology, 2009, Robert, Hélène S; Friml, Jirí
Design, synthesis and sequence selective DNA cleavage of functional models of bleomycin—II. 1,2- trans-disubstituted cyclopropane units as novel linkers
score: 0.23072417, Bioorganic & Medicinal Chemistry, 1995, Huang, Liren; Quada, James C.; William Lown, J.
Expression of mouse Gal,ß14GlcNAc α2,6-sialyl-transferase in an insoluble form in Escherichia coli and partial renaturation
score: 0.23071808, Bioorganic & Medicinal Chemistry, 1994, Hamamoto, Toshiro et. al.
A very good place to start.
score: 0.23061595, Nature chemical biology, 2009,
Revolutionary functional genomics liberates CHE.
score: 0.23056258, Nature chemical biology, 2009, Robertson, Fiona C; Webb, Alex A R
QSPR Studies on Aqueous Solubilities of Drug-Like Compounds
score: 0.23051579, International Journal of Molecular Sciences, 2009, Duchowicz, Pablo R.; Castro, Eduardo A.
Watching single protons bind.
score: 0.23042574, Nature chemical biology, 2006, Akabas, Myles H
Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation
score: 0.23026951, Chemistry & Biology, 2012, Wu, Lily et. al.
Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors
score: 0.22969303, Chemistry & Biology, 1998, Rodgers, James D. et. al.
Molecular basis of the interaction of novel tributyltin(IV) 2/4-[( E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: Synthesis, structure, biological efficacy and QSAR studies
score: 0.22963838, Journal of Inorganic Biochemistry, 2010, Basu Baul, Tushar S. et. al.
Proteomics: mapping reactive cysteines.
score: 0.22943835, Nature chemical biology, 2011, Marino, Stefano M; Gladyshev, Vadim N
Development of copper based drugs, radiopharmaceuticals and medical materials
score: 0.22937222, Biometals, 2012, Szymański, Paweł et. al.
Structure-based virtual ligand screening with LigandFit: pose prediction and enrichment of compound collections.
score: 0.22907882, Proteins, 2007, Montes, Matthieu; Miteva, Maria A; Villoutreix, Bruno O
Identification of N-phenyl- N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4
score: 0.22871094, Virology, 2005, Zhao, Qian et. al.
Cycloaddition and related reactions of cephalosporin antibiotics
score: 0.22840362, Bioorganic & Medicinal Chemistry, 1995, Pitlik, János
CHEMICAL MODIFICATION OF STARCH
score: 0.22833307, Advances in Carbohydrate Chemistry and Biochemistry, 2004, Tomasik, Piotr; Schilling, Christopher H.
The biological activity of cyclic bis(bibenzyls): a rational approach
score: 0.227806, Bioorganic & Medicinal Chemistry, 1995, Keseru, György M.; Nógrádi, Mihály
Intramolecular carboxylate catalysis in the depurination of a 7-methylguanosine derivative
score: 0.22747927, Bioorganic & Medicinal Chemistry, 1993, Van Arman, Scott A.; Czarnik, Anthony W.
Three-dimensional QSAR of HPPD inhibitors, PSA inhibitors, and anxiolytic agents: Effect of tautomerism on the CoMFA models
score: 0.22746532, Journal of Molecular Graphics and Modelling, 2007, Zou, Jian-Wei et. al.
Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology.
score: 0.22738649, Environmental toxicology and chemistry / SETAC, 2003, Perkins, Roger; Fang, Hong; Tong, Weida; Welsh, William J
The chemical biology of synapses and neuronal circuits.
score: 0.22732447, Nature chemical biology, 2010, Bito, Haruhiko
Theoretical quantitative structure—activity relationship analysis on three dimensional models of ligand—m1 muscarinic receptor complexes
score: 0.22702937, Bioorganic & Medicinal Chemistry, 1994, Fanelli, Francesca et. al.
Three-dimensional quantitative structure–activity relationship (3D-QSAR) analyses of choline acetyltransferase inhibitors
score: 0.22573244, Journal of Molecular Graphics and Modelling, 2004, Chandrasekaran, Vasudevan et. al.
Nitric oxide-induced nitration of catecholamine neurotransmitters: A key to neuronal degeneration?
score: 0.22528634, Bioorganic & Medicinal Chemistry, 1995, d'Ischia, Marco; Costantini, Claudio
Mining the Chemical Abstracts database with pharmacophore-based queries
score: 0.22525658, Journal of Molecular Graphics and Modelling, 2002, Bremner, John B et. al.
Proteolytic needles in the cellular haystack.
score: 0.22523542, Nature chemical biology, 2008, Enoksson, Mari; Salvesen, Guy S
Synthesis and pharmacological evaluation of new4-[2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethyl]benzoic acidsas LTD 4-antagonists
score: 0.22490131, European Journal of Medicinal Chemistry, 2000, Ballart, Berta et. al.
Trafficking and signaling by fatty-acylated and prenylated proteins.
score: 0.22444739, Nature chemical biology, 2006, Resh, Marilyn D
Metallophthalocyanines as possible lignin peroxidase models
score: 0.22393093, Bioorganic & Medicinal Chemistry, 1995, Cui, Futong; Dolphin, David
Synthesis of [Phe(4F) 3]thymopoietin II and examination of its immunological effect on the impaired blastogenic response of T-lymphocytes of uremic patients
score: 0.22263136, Bioorganic & Medicinal Chemistry, 1995, Abiko, Takashi; Sekino, Hiroshi
Design, synthesis and pharmacological evaluation of 4-[2-alkylthio-5(4)-(4-substitutedphenyl)imidazole-4(5)yl]benzenesulfonamides as selective COX-2 inhibitors.
score: 0.22258036, Acta pharmacologica Sinica, 2007, Salimi, Mona et. al.
Diversity in chemistry: catalyzing change.
score: 0.22254508, Nature chemical biology, 2007, Epstein, Irving R
Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.
score: 0.22217652, Antimicrobial agents and chemotherapy, 1997, Neamati, N et. al.
Antitrypanosomal and Cytotoxic Activities of 22-Hydroxyclerosterol, a New Sterol from Allexis cauliflora (Violaceae)
score: 0.222011, Scientia Pharmaceutica, 2011, Nganso, Yves Oscar D. et. al.
A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents.
score: 0.22178422, Antimicrobial agents and chemotherapy, 1997, Cushion, M T; Chen, F; Kloepfer, N
Application and limitations of the methyl imidate protection strategy of N-acetylglucosamine for glycosylations at O-4: synthesis of Lewis A and Lewis X trisaccharide analogues
score: 0.22094549, Carbohydrate Research, 2008, Hendel, Jenifer L. et. al.
Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors
score: 0.22081955, PLoS ONE, 2012, Daidone, Frederick et. al.
New Noncovalent Inhibitors of Penicillin-Binding Proteins from Penicillin-Resistant Bacteria
score: 0.22069787, PLoS ONE, 2011, Turk, Samo et. al.
Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers.
score: 0.2206043, Nature chemical biology, 2005, Pautot, Sophie; Lee, Hanson; Isacoff, Ehud Y; Groves, Jay T
Rabbit model for Chlamydia pneumoniae infection.
score: 0.22032925, Journal of clinical microbiology, 1997, Fong, I W; Chiu, B; Viira, E; Fong, M W; Jang, D; Mahony, J
FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
score: 0.22027716, BMC Bioinformatics, 2008, Lagorce, David et. al.
Correlation and prediction of a large blood–brain distribution data set—an LFER study
score: 0.21972014, European Journal of Medicinal Chemistry, 2001, Platts, James A. et. al.
How good is your screening library?
score: 0.21896743, Current Opinion in Chemical Biology, 2006, Irwin, John J
Sortagging: a versatile method for protein labeling.
score: 0.21876992, Nature chemical biology, 2007, Popp, Maximilian W et. al.
Solution structure of endothelin B receptor selective antagonist RES-701-1 determined by 1H NMR spectroscopy
score: 0.21874728, Bioorganic & Medicinal Chemistry, 1995, Katahira, Ritsuko et. al.
In vitro antibacterial activity of ME1207, a new oral cephalosporin.
score: 0.21852856, Antimicrobial agents and chemotherapy, 1991, Miyazaki, S; Miyazaki, Y; Tsuji, A; Nishida, M; Goto, S
Investigation on Quantitative Structure Activity Relationships and Pharmacophore Modeling of a Series of mGluR2 Antagonists
score: 0.21796271, International Journal of Molecular Sciences, 2011, Zhang, Meng-Qi et. al.
Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines
score: 0.21782375, European Journal of Medicinal Chemistry, 2001, Palaska, Erhan; Aytemir, Mutlu; Uzbay, İ.Tayfun; Erol, Dilek
Protein Flexibility in Ligand Docking and Virtual Screening to Protein Kinases
score: 0.21770568, Journal of Molecular Biology, 2004, Cavasotto, Claudio N.; Abagyan, Ruben A.
6-Substituted pyrrolo[3,4-c]pyrazoles: an improved class of CDK2 inhibitors.
score: 0.21729911, ChemMedChem, 2007, Brasca, Maria Gabriella et. al.
Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.
score: 0.21707414, Antimicrobial agents and chemotherapy, 1997, Rice, W G et. al.
Exploring the structure requirement for PKCθ inhibitory activity of pyridinecarbonitrile derivatives: an in silico analysis
score: 0.21632564, Journal of Molecular Graphics and Modelling, 2012, Li, Yan et. al.
Exploring the structure requirement for PKCθ inhibitory activity of pyridinecarbonitrile derivatives: an in silico analysis
score: 0.21632564, Journal of Molecular Graphics and Modelling, 2012, Li, Yan et. al.
Brownian search-and-catch mechanism for myosin-VI steps.
score: 0.21620838, Nature chemical biology, 2009, Iwaki, Mitsuhiro et. al.
Synthesis and antiviral effects of 2-heteroaryl substituted adenosine and 8-heteroaryl substituted guanosine derivatives
score: 0.21577126, Bioorganic & Medicinal Chemistry, 1995, Persson, Tina et. al.
Targeting Apoptosis via Chemical Design
score: 0.215179, Chemistry & Biology, 2004, Becattini, Barbara et. al.
Synthesis and Evaluationof Substituted Chroman-4-oneand Chromone Derivatives as Sirtuin 2-Selective Inhibitors
score: 0.21503097, Journal of Medicinal Chemistry, 2012, Fridén-Saxin, Maria et. al.
Pharmacophore design and database searching for selective monoamine neurotransmitter transporter ligands
score: 0.21493431, Journal of Molecular Graphics and Modelling, 2008, MacDougall, Iain J.A.; Griffith, Renate
SLC6 neurotransmitter transporters: structure, function, and regulation.
score: 0.21488216, Pharmacological reviews, 2011, Kristensen, Anders S et. al.
Bacillithiol is an antioxidant thiol produced in Bacilli
score: 0.21473737, Nature chemical biology, 2009, Newton, Gerald L. et. al.
A universal code for RNA recognition by PUF proteins.
score: 0.21417236, Nature chemical biology, 2011, Filipovska, Aleksandra et. al.
TREMORGENIC AND NONTREMORGENIC 2,3-FUSED INDOLE DITERPENOIDS
score: 0.21287958, The Alkaloids, 2003, Sings, Heather; Singh, Sheo
An Inhibitor of the Human UDP-GlcNAc 4-Epimerase Identified from a Uridine-Based Library
score: 0.2126927, Chemistry & Biology, 2002, Winans, Katharine A; Bertozzi, Carolyn R
Relaxed specificity in aromatic prenyltransferases.
score: 0.2118656, Nature chemical biology, 2005, Koehl, Patrice
Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.
score: 0.21115712, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Wu, Fang et. al.
Adventures in Carbohydrate Chemistry: New Synthetic Technologies, Chemical Synthesis, Molecular Design, and Chemical Biology A list of abbreviations can be found at the end of this article. Telemachos Charalambous was an inspiring teacher at the Pancyprian Gymnasium, Nicosia, Cyprus.
score: 0.21064253, Angewandte Chemie (International ed. in English), 2001, Nicolaou, K. C.; Mitchell, Helen J.
Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate.
score: 0.21016118, Nature chemical biology, 2009, Pavlova, Martina et. al.
TREMORGENIC AND NONTREMORGENIC 2,3-FUSED INDOLE DITERPENOIDS
score: 0.20998398, The Alkaloids, 2003, Sings, Heather; Singh, Sheo
TREMORGENIC AND NONTREMORGENIC 2,3-FUSED INDOLE DITERPENOIDS
score: 0.20998398, The Alkaloids, 2003, Sings, Heather; Singh, Sheo
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
score: 0.2098423, ChemMedChem, 2011, Hampton, Shahienaz E et. al.
Progress in the discovery of selective, high affinity A 2B adenosine receptor antagonists as clinical candidates
score: 0.20959079, Purinergic Signalling, 2008, Kalla, Rao V.; Zablocki, Jeff
Bifunctional activity labels for selection of filamentous bacteriophages displaying enzymes
score: 0.20947111, Bioorganic & Medicinal Chemistry, 1995, Vanwetswinkel, Sophie et. al.
An ATP-independent strategy for amide bond formation in antibiotic biosynthesis.
score: 0.20943739, Nature chemical biology, 2010, Funabashi, Masanori et. al.
The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction.
score: 0.20932526, Nature chemical biology, 2006, Banci, Lucia et. al.
In vivo therapeutic efficacies of PD 138312 and PD 140248, two novel fluoronaphthyridines with outstanding gram-positive potency.
score: 0.20896509, Antimicrobial agents and chemotherapy, 1995, Shapiro, M A et. al.
Urate to allantoin, specifically (S)-allantoin.
score: 0.20856857, Nature chemical biology, 2006, Tipton, Peter A
Focal adhesion: getting a grasp on myxobacterial gliding.
score: 0.20854397, Nature chemical biology, 2007, Shi, Wenyuan; Lux, Renate
Signaling-mediated bacterial persister formation.
score: 0.20821769, Nature chemical biology, 2012, Vega, Nicole M et. al.
Reversible modification of tissue-type plasminogen activator by methylphosphonate esters
score: 0.20770242, Bioorganic & Medicinal Chemistry, 1996, Zhao, Qinjian; Kovach, Ildiko M
17α-Alkan (or alkyn) amide derivatives of estradiol as inhibitors of steroid-sulfatase activity
score: 0.20726612, Steroids, 1999, Boivin, Roch P; Labrie, Fernand; Poirier, Donald
Mechanisms for copper acquisition, distribution and regulation.
score: 0.20709929, Nature chemical biology, 2008, Kim, Byung-Eun; Nevitt, Tracy; Thiele, Dennis J
Conformational change due to esterification of hydroxy groups in erythromycin A and its major metabolite: Analysis of these derivatives with different biological properties using NMR and Molecular Dynamics (MD) data
score: 0.2069957, Bioorganic & Medicinal Chemistry, 1995, Ladam, Patrick et. al.
Combined 3D-QSAR Modeling and Molecular Docking Studies on Pyrrole-Indolin-2-ones as Aurora A Kinase Inhibitors
score: 0.20543113, International Journal of Molecular Sciences, 2011, Ai, Yong; Wang, Shao-Teng; Sun, Ping-Hua; Song, Fa-Jun
Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
score: 0.20525386, The Journal of pharmacology and experimental therapeutics, 2008, Gardell, Luis R et. al.
Small molecule-induced DNA damage identifies alternative DNA structures in human genes
score: 0.20518074, Nature chemical biology, 2012, Rodriguez, Raphaël et. al.
Chemical "knockout" challenges the amphotericin B channel model.
score: 0.20509229, Nature chemical biology, 2008, Kozmin, Sergey A
The conformation and activity relationship of benzofuran derivatives as angiotensin II receptor antagonists
score: 0.20496145, Bioorganic & Medicinal Chemistry, 1997, Yoo, Sung-eun et. al.
A theoretical entropy score as a single value to express inhibitor selectivity
score: 0.20479874, BMC Bioinformatics, 2011, Uitdehaag, Joost CM; Zaman, Guido JR
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes.
score: 0.20435224, Nature chemical biology, 2010, Wu, Yao-Wen et. al.
Electrostatic couplings in OmpA ion-channel gating suggest a mechanism for pore opening.
score: 0.20405225, Nature chemical biology, 2006, Hong, Heedeok; Szabo, Gabor; Tamm, Lukas K
The chemistry of oligosaccharide ligands of selectins: Significance for the development of new immunomodulatory medicines
score: 0.20369341, Advances in Carbohydrate Chemistry and Biochemistry, 2001, Unger, Frank M.
One-electron oxidation of DNA and inflammation processes.
score: 0.20347821, Nature chemical biology, 2006, Cadet, Jean; Douki, Thierry; Ravanat, Jean-Luc
Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry.
score: 0.20326265, Nature chemical biology, 2010, Milne, Stephen B et. al.
What's in a review?
score: 0.20284478, Nature chemical biology, 2010,
New EPSP synthase inhibitors: Synthesis and evaluation of an aromatic tetrahedral intermediate mimic containing a 3-malonate ether as a 3-phosphate surrogate
score: 0.20279897, Bioorganic & Medicinal Chemistry, 1995, Miller, Michael J. et. al.
Biologically active dihydropyrimidones of the Biginelli-type — a literature survey
score: 0.20240877, European Journal of Medicinal Chemistry, 2000, Kappe, C.Oliver
Shining a light on protein expression in living organisms.
score: 0.20221621, Nature chemical biology, 2007, Perler, Francine B
Design, synthesis, DNA-binding and cytotoxicity evaluation of new potential combilexines
score: 0.20204864, European Journal of Medicinal Chemistry, 2002, Hotzel, Christian; Marotto, Annalisa; Pindur, Ulf
Timing Facilitated Site Transfer of an Enzyme on DNA
score: 0.20200249, Nature Chemical Biology, 2011, Schonhoft, Joseph D.; Stivers, James T.
Determination of 3 1-stereochemistry in synthetic bacteriochlorophyll- d homologues and self-aggregation of their zinc complexes
score: 0.20153586, Bioorganic & Medicinal Chemistry, 2004, Tamiaki, Hitoshi et. al.
Temperature-dependent STIM1 activation induces Ca 2+ influx and modulates gene expression
score: 0.20063784, Nature chemical biology, 2011, Xiao, Bailong et. al.
Talking science.
score: 0.20062859, Nature chemical biology, 2011,
Teaching undergraduates at the interface of chemistry and biology: challenges and opportunities.
score: 0.20057402, Nature chemical biology, 2005, Godwin, Hilary Arnold; Davis, Benjamin Lee
Building a new conceptual framework for receptor heteromers.
score: 0.19988235, Nature chemical biology, 2009, Ferré, Sergi et. al.
Affinity probes for the GABA-gated chloride channel: Selection of 5 e- tert-Butyl-2 e-[4-(substituted-ethynyl)phenyl]-1,3-dithianes and optimization of linker moiety
score: 0.19948373, Bioorganic & Medicinal Chemistry, 1995, Li, Qing X.; Casida, John E.
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.
score: 0.19873184, Antimicrobial agents and chemotherapy, 1993, Srinivas, R V et. al.
Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs: a comparative molecular field analysis (CoMFA) revisited study
score: 0.19858487, Chemistry Central Journal, 2012, Hamad Elgazwy, Abdel-Sattar S et. al.
Identification of novel orally available small molecule insulin mimetics.
score: 0.19840048, The Journal of pharmacology and experimental therapeutics, 2007, Lin, Bo et. al.
(2-Arylhydrazonomethyl)-substituted xanthones as antimycotics: synthesis and fungistatic activity against Candida species
score: 0.19819514, European Journal of Medicinal Chemistry, 2002, Moreau, Stéphane et. al.
Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes
score: 0.19807312, Chemistry Central Journal, 2013, Yang, Shengjie et. al.
New insights into calicheamicin-DNA interactions derived from a model nucleosome system
score: 0.19780931, Bioorganic & Medicinal Chemistry, 1995, Yu, Li; Salzberg, Aaron A.; Dedon, Peter C.
Flip-flopping salt bridges gate an ion channel.
score: 0.19777202, Nature chemical biology, 2006, Moroni, Anna; Thiel, Gerhard
A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation.
score: 0.19745359, Nature chemical biology, 2010, Schwarz, Flavio et. al.
Lessons and revelations from biomimetic syntheses.
score: 0.19701796, Nature chemical biology, 2011, Razzak, Mina; De Brabander, Jef K
Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) and other antiviral compounds.
score: 0.19697818, Antimicrobial agents and chemotherapy, 1990, Akesson-Johansson, A; Harmenberg, J; Wahren, B; Linde, A
Structure-activity studies of sulfate transfer: the hydrolysis and aminolysis of 3′-phosphoadenosine 5′-phosphosulfate (PAPS)
score: 0.1965291, Bioorganic & Medicinal Chemistry, 1995, Bedford, Colin T. et. al.
A method for including protein flexibility in protein-ligand docking: improving tools for database mining and virtual screening 1 1 Color plates for this article are on pages 302–304.
score: 0.19644549, Journal of Molecular Graphics and Modelling, 2000, Broughton, Howard B.
FTIR spectral study of intramolecular hydrogen bonding in E-type of 15-keto-prostaglandins in dilute CCl 4 solution: Structure-activity relationships
score: 0.19624105, Bioorganic & Medicinal Chemistry, 1995, Takasuka, Mamoru; Yamakawa, Masumi
Applications of random sampling to virtual screening of combinatorial libraries
score: 0.19603307, Journal of Molecular Graphics and Modelling, 2000, Beroza, Paul et. al.
Learning biological networks: from modules to dynamics.
score: 0.19576918, Nature chemical biology, 2008, Bonneau, Richard
Stuart Levy.
score: 0.1933237, Nature chemical biology, 2006, Kotz, Joanne
Synthesis and interaction studies of 13C labeled lactone derivatives with a model protein using 13C NMR
score: 0.19311317, Bioorganic & Medicinal Chemistry, 1993, Franot, Christelle et. al.
Action of uracil analogs on human immunodeficiency virus type 1 and its reverse transcriptase.
score: 0.19276649, Antimicrobial agents and chemotherapy, 1995, Piras, G et. al.
Meliavolkenin, a new bioactive triterpenoid from Melia volkensii (Meliaceae)
score: 0.1927304, Bioorganic & Medicinal Chemistry, 1995, Zeng, Lu et. al.
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)
score: 0.19248009, Biochimie, 2010, Goettig, Peter; Magdolen, Viktor; Brandstetter, Hans
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)
score: 0.19248009, Biochimie, 2010, Goettig, Peter; Magdolen, Viktor; Brandstetter, Hans
Evidence for an intermediate in the enzymatic formation of Uroporphyrinogen III
score: 0.19235756, Bioorganic & Medicinal Chemistry, 1994, Pichon, Clotilde et. al.
Chemical answers to epigenetic crosstalk.
score: 0.19167021, Nature chemical biology, 2008, Lee, Nara; Zhang, Yi
Protein lysine methyltransferase G9a acts on non-histone targets.
score: 0.19158668, Nature chemical biology, 2008, Rathert, Philipp et. al.
Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage
score: 0.19145411, European Journal of Medicinal Chemistry, 2001, Caliendo, Giuseppe et. al.
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners
score: 0.19139218, Bioorganic & Medicinal Chemistry, 1996, Groutas, William C. et. al.
Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)
score: 0.19082918, Chemmedchem, 2011, Woo, L W Lawrence et. al.
In vitro antibacterial activity of AM-1155, a novel 6-fluoro-8-methoxy quinolone.
score: 0.1907196, Antimicrobial agents and chemotherapy, 1994, Wakabayashi, E; Mitsuhashi, S
Development and screening of a polyketide virtual library for drug leads against a motilide pharmacophore
score: 0.19058419, Journal of Molecular Graphics and Modelling, 2000, Siani, Michael A. et. al.
Synthesis of racemic 6,10,14-trimethylpentadecan-2-ol, a pheromone of rice moth and 5,9,13-trimethyltetradecanoic acid, a component of marine sponge from a common intermediate
score: 0.1900474, Bioorganic & Medicinal Chemistry, 1993, Rane, Sneha S.; Chadha, M.S.; Mamdapur, V.R.
Continuous indirect electrochemical regeneration of galactose oxidase
score: 0.18964298, Bioorganic & Medicinal Chemistry, 1999, Petersen, Arne; Steckhan, Eberhard
A novel biotinylated heterobifunctional cross-linking reagent bearing an aromatic diazirine
score: 0.18963505, Bioorganic & Medicinal Chemistry, 1994, Hatanaka, Yasumaru; Hashimoto, Makoto; Kanaoka, Yuichi
Structure–activity relationship of dihydroxy-4-methylcoumarins as powerful antioxidants: Correlation between experimental & theoretical data and synergistic effect
score: 0.18914205, Biochimie, 2010, Kancheva, Vessela D. et. al.
Dioxides of bicyclic thiadiazines: a new family of smooth muscle relaxants
score: 0.18846401, Bioorganic & Medicinal Chemistry, 1995, Castro, Ana; Martínez, Ana; Cardelús, Ignasi; Llenas, Jesús
From fragment to clinical candidate—a historical perspective
score: 0.18827863, Drug Discovery Today, 2009, Chessari, Gianni; Woodhead, Andrew J.
Design, synthesis, and immunochemical characterization of a chimeric glycopeptide corresponding to the Shigella flexneri Y O-polysaccharide and its peptide mimic MDWNMHAA
score: 0.18792269, Carbohydrate Research, 2009, Hossany, B. Rehana et. al.
Two Birds with One Stone? Possible Dual-Targeting H1N1 Inhibitors from Traditional Chinese Medicine
score: 0.18775023, PLoS Computational Biology, 2011, Chang, Su-Sen; Huang, Hung-Jin; Chen, Calvin Yu-Chian
HIV-1 and microvesicles from T-cells share a common glycome, arguing for a common origin
score: 0.18770894, Nature chemical biology, 2009, Krishnamoorthy, Lakshmi et. al.
The chemistry of oligosaccharide ligands of selectins: Significance for the development of new immunomodulatory medicines
score: 0.18727481, Advances in Carbohydrate Chemistry and Biochemistry, 2001, Unger, Frank M.
Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases.
score: 0.18713174, Nature chemical biology, 2006, Dalhoff, Christian et. al.
Enantioselective inhibition of the epidermal growth factor receptor tyrosine kinase by 4-(α-phenethylamino)quinazolines
score: 0.18628088, Bioorganic & Medicinal Chemistry, 1995, Bridges, Alexander J. et. al.
Relative to Quinine and Quinidine, Their 9-Epimers Exhibit Decreased Cytostatic Activity and Altered Heme Binding, but Similar Cytocidal Activity versus P. falciparum.
score: 0.18557015, Antimicrobial agents and chemotherapy, 2012, Gorka, Alexander P et. al.
Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5).
score: 0.18552325, Drug metabolism and disposition: the biological fate of chemicals, 2007, Jones, David R; Ekins, Sean; Li, Lang; Hall, Stephen D
Opening the pore hinges on proline.
score: 0.18526745, Nature chemical biology, 2006, Andreotti, Amy H
Screening for Cell Migration Inhibitors via Automated Microscopy Reveals a Rho-Kinase Inhibitor
score: 0.18502618, Chemistry & Biology, 2005, Yarrow, Justin C. et. al.
Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.
score: 0.18501592, Antimicrobial agents and chemotherapy, 1997, Ridley, R G et. al.
Research on the structure-surface adsorptive activity relationships of triazolyl glycolipid derivatives for mild steel in HCl
score: 0.18449315, Carbohydrate Research, 2012, Zhang, Hai-Lin et. al.
Integrating molecular design resources within modern drug discovery research: the Roche experience
score: 0.1841821, Drug Discovery Today, 2006, Stahl, Martin; Guba, Wolfgang; Kansy, Manfred
3 Recent Progress Toward Nonpeptide Ligands for the Melanocortin-4 Receptor
score: 0.18340559, Progress in Medicinal Chemistry, 2007, Chen, Chen
Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]- N, N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives
score: 0.18322616, European Journal of Medicinal Chemistry, 2001, de Souza, Ana O et. al.
Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives
score: 0.18293836, European Journal of Medicinal Chemistry, 2001, Learmonth, David A et. al.
Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor
score: 0.1827432, Biochemical Pharmacology, 2008, Küblbeck, Jenni et. al.
Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.
score: 0.18211008, Antimicrobial agents and chemotherapy, 1995, Knox, J R
Enzymes for the resolution of α-tertiary-substituted carboxylic acid esters
score: 0.18159039, Bioorganic & Medicinal Chemistry, 1994, Kallwass, Helmut K.W. et. al.
Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform.
score: 0.18104664, Nucleic acids research, 2009, Holt, Patrick A et. al.
Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Inhibitors
score: 0.18093549, The Journal of Organic Chemistry, 2011, Nordqvist, Anneli et. al.
Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin
score: 0.18044108, Marine Drugs, 2012, Chen, Hong et. al.
The polypeptide 3 10-helix as a template for molecular recognition studies. Structural characterization of a sidechain functionalized octapeptide
score: 0.17954956, Bioorganic & Medicinal Chemistry, 1995, Toniolo, Claudio et. al.
Force probing surfaces of living cells to molecular resolution.
score: 0.17943787, Nature chemical biology, 2009, Müller, Daniel J et. al.
Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes
score: 0.17895919, PLoS ONE, 2012, Viswanathan, Kishore et. al.
Extraction of pharmacophore information from high-throughput screens
score: 0.17892929, Current Opinion in Biotechnology, 2000, Hopfinger, Anton J; Duca, José S
Two- and Three-Dimensional Quantitative Structure-Activity Relationships Studies on a Series of Liver X Receptor Ligands
score: 0.17871993, The Open Medicinal Chemistry Journal, 2008, Honório, Káthia M et. al.
Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression.
score: 0.17861632, Nature chemical biology, 2011, Xiao, Bailong et. al.
Theoretical study of anthracycline antibiotic analogues—III. Conformational analysis on different 2,6-dideoxy-2-halo-α- l-hexopyranoses by molecular mechanics and semiempirical methods
score: 0.17846815, Bioorganic & Medicinal Chemistry, 1996, El Bergmi, Redouan; Molina Molina, José
Contributions of counter-charge in a potassium channel voltage-sensor domain.
score: 0.1784125, Nature chemical biology, 2011, Pless, Stephan A et. al.
Biology and brimstone.
score: 0.17807161, Nature chemical biology, 2006,
Synthesis, physico-chemical properties and complexing abilities of new amphiphilic ligands from d-galacturonic acid
score: 0.17800384, Carbohydrate Research, 2010, Allam, Anas et. al.
Immunoenhancing properties and antiviral activity of 7-deazaguanosine in mice.
score: 0.1778342, Antimicrobial agents and chemotherapy, 1991, Smee, D F et. al.
Asymmetry and dynamics in bis-intercalated DNA
score: 0.17731292, Bioorganic & Medicinal Chemistry, 1995, Peek, Mary Elizabeth et. al.
DNA-DNA interstrand cross-linking by cis-diamminedichloroplatinum(II): N7(dG)-N7(dG) cross-linking at 5′-d(GC) in synthetic oligonucleotides
score: 0.17695331, Bioorganic & Medicinal Chemistry, 1995, Huang, Huifang et. al.
Classification of cytochrome P450 1A2 inhibitors and noninhibitors by machine learning techniques.
score: 0.17675943, Drug metabolism and disposition: the biological fate of chemicals, 2009, Vasanthanathan, Poongavanam et. al.
Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone.
score: 0.17547361, Antimicrobial agents and chemotherapy, 1993, Yoshida, T; Mitsuhashi, S
Inhibition of adhesion molecule expression by N-alkylthiopyridine-benzo[ b]thiophene-2-carboxamides
score: 0.17527621, Bioorganic & Medicinal Chemistry, 1996, Boschelli, Diane H. et. al.
Identification and mapping of small-molecule binding sites in proteins: computational tools for structure-based drug design
score: 0.17487059, Il Farmaco, 2002, Sotriffer, Christoph; Klebe, Gerhard
Enzymatic synthesis of isotopically labeled isoprenoid diphosphates
score: 0.17472785, Bioorganic & Medicinal Chemistry, 1994, Christensen, Dale J.; Poulter, C.Dale
Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats.
score: 0.17438006, Antimicrobial agents and chemotherapy, 1992, Schmatz, D M et. al.
Antimicrobial properties of 8-hydroxyserrulat-14-en-19-oic acid for the treatment of implant-associated infections.
score: 0.17334901, Antimicrobial agents and chemotherapy, 2012, Nowakowska, Justyna et. al.
HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin.
score: 0.17327164, Nature chemical biology, 2009, Krishnamoorthy, Lakshmi et. al.
Toward understanding the molecular basis for chemical allosteric modulator design
score: 0.1731742, Journal of Molecular Graphics and Modelling, 2012, Wang, Qi et. al.
Toward understanding the molecular basis for chemical allosteric modulator design
score: 0.1731742, Journal of Molecular Graphics and Modelling, 2012, Wang, Qi et. al.
Toward understanding the molecular basis for chemical allosteric modulator design
score: 0.1731742, Journal of Molecular Graphics and Modelling, 2012, Wang, Qi et. al.
NP-06: a novel anti-human immunodeficiency virus polypeptide produced by a Streptomyces species.
score: 0.17310569, Antimicrobial agents and chemotherapy, 1995, Chokekijchai, S et. al.
Controlled S-nitrosation.
score: 0.17306259, Nature chemical biology, 2005, Tannenbaum, Steven R; Kim, Ji-Eun
Synthesis and post-coital contraceptive activity of ether and ester analogues of 2,3-diaryl-2H-1-benzopyrans
score: 0.17305985, Bioorganic & Medicinal Chemistry, 1995, Hajela, Kanchan; Kapoor, Kamal K.; Kapil, Randhir S.
In vitro activity of Bay Y3118 against anaerobic bacteria.
score: 0.17296063, Antimicrobial agents and chemotherapy, 1993, Wexler, H M; Molitoris, E; Finegold, S M
GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.
score: 0.17236698, Antimicrobial agents and chemotherapy, 1996, Stieger, M; Angehrn, P; Wohlgensinger, B; Gmünder, H
Docking studies of agonists and antagonists suggest an activation pathway of the A 3 adenosine receptor
score: 0.17222756, Journal of Molecular Graphics and Modelling, 2006, Kim, Soo-Kyung et. al.
Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective
score: 0.17176272, Drug Discovery Today, 2007, Zhao, Hongyu
Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers
score: 0.1715851, PLoS ONE, 2010, Kruewel, Thomas et. al.
Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats.
score: 0.17120005, The Journal of pharmacology and experimental therapeutics, 2008, Brady, Ashley E et. al.
Enzymatic preparation of (4 R,6 R)-4-hydroxy-1,7-dioxaspiro[5.5]undecane and its antipode, the minor component of the olive fruit fly pheromone
score: 0.17117887, Bioorganic & Medicinal Chemistry, 1996, Yokoyama, Yūsuke; Takikawa, Hirosato; Mori, Kenji
Comparative in vitro activity of PD 127391, a new fluoroquinolone agent, against susceptible and resistant clinical isolates of gram-positive cocci.
score: 0.17062121, Antimicrobial agents and chemotherapy, 1992, Miranda, A G; Wanger, A R; Singh, K V; Murray, B E
Isosterism among analogues of torasemide: conformational, electronic and lipophilicity properties
score: 0.17036157, European Journal of Medicinal Chemistry, 2000, Wouters, Johan et. al.
Utilization of NMR-Derived Fragment Leads in Drug Design
score: 0.16970532, Methods in Enzymology, 2005, Huth, Jeffrey R. et. al.
Utilization of NMR-Derived Fragment Leads in Drug Design
score: 0.16970532, Methods in Enzymology, 2005, Huth, Jeffrey R. et. al.
Targeting signal transduction with large combinatorial collections
score: 0.16908846, Drug Discovery Today, 2002, Auld, Douglas S.; Diller, David; Ho, Koc-Kan
Discovery and preclinical evaluation of a novel class of small-molecule compounds in hormone-dependent and -independent cancer cell lines.
score: 0.16895585, Molecular cancer therapeutics, 2005, Plasencia, Carmen et. al.
High-throughput screening flows along.
score: 0.16895096, Nature chemical biology, 2007, Fenniri, Hicham; Alvarez-Puebla, Ramon
Structural basis for regulation of the Crk signaling protein by a proline switch.
score: 0.16885233, Nature chemical biology, 2011, Sarkar, Paramita et. al.
Triazolyl–benzimidazolones and triazolyl–benzotriazoles: new potential potassium channel activators. II
score: 0.16811241, European Journal of Medicinal Chemistry, 2000, Baragatti, Barbara et. al.
Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3
score: 0.16761613, Bioorganic & Medicinal Chemistry, 1995, Groutas, William C. et. al.
The tRNA synthetase paralog PoxA modifies elongation factor-P with ( R )-β-lysine
score: 0.1675521, Nature chemical biology, 2011, Roy, Hervé et. al.
Cleaving C-Hg bonds: two thiolates are better than one.
score: 0.16724313, Nature chemical biology, 2007, Miller, Susan M
Renin inhibitor SC-51106 complexed with human renin: Discovery of a new binding site adjacent to P 3
score: 0.16695878, Bioorganic & Medicinal Chemistry, 1994, Hanson, Gunnar J. et. al.
New tripeptidic thrombin inhibitors. Influence of P2 and P3 residues on activity and selectivity
score: 0.16657932, Bioorganic & Medicinal Chemistry, 1995, De Nanteuil, Guillaume et. al.
CoMFA based de novo design of pyridazine analogs as PTP1B inhibitors
score: 0.16650594, Journal of Molecular Graphics and Modelling, 2007, Nair, Pramod C.; Sobhia, M. Elizabeth
Reactions of diazines with nucleophiles—IV 1. the reactivity of 5-bromo-1,3,6-trimethyluracil with thiolate ions—substitution versus X-philic versus single electron transfer reactions
score: 0.16608554, Bioorganic & Medicinal Chemistry, 1995, Kumar, Subodh et. al.
Synthesis and biological evaluation of N-substituted indole esters as inhibitors of cyclo-oxygenase-2 (COX-2)
score: 0.16583964, Il Farmaco, 2002, Ölgen, Süreyya; Nebioğlu, Doğu
3D-QSAR Design of New Escitalopram Derivatives for the Treatment of Major Depressive Disorders
score: 0.1657564, Scientia Pharmaceutica, 2010, Avram, Speranta et. al.
Thermostability and thermoactivity of enzymes from hyperthermophilic archaea
score: 0.1653171, Bioorganic & Medicinal Chemistry, 1994, Adams, M.W.W.; Kelly, R.M.
Visualizing substructural fingerprints
score: 0.16523096, Journal of Molecular Graphics and Modelling, 2000, Clark, Robert D. et. al.
In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine.
score: 0.1650584, Antimicrobial agents and chemotherapy, 1993, Kageyama, S et. al.
Lox and Cre sandwich.
score: 0.16456564, Nature chemical biology, 2005, Lee, Linda; Sadowski, Paul D
Steroidomimetic Tetrahydroisoquinolinesfor the Designof New Microtubule Disruptors
score: 0.16422699, ACS Medicinal Chemistry Letters, 2011, Leese, Mathew P. et. al.
New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat.
score: 0.16409939, Antimicrobial agents and chemotherapy, 1995, Schmatz, D M et. al.
Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome.
score: 0.16290428, Nature chemical biology, 2010, Sakurai, Masayuki et. al.
Engineering fluorination.
score: 0.16216743, Nature chemical biology, 2009, Sandford, Graham
Potential radioprotective agents—VI. Chalcones, benzophenones, acid hydrazides, nitro amines and chloro compounds. radioprotection of murine intestinal stem cells
score: 0.16210179, Bioorganic & Medicinal Chemistry, 1995, Blickenstaff, Robert T. et. al.
Three decades of beta-lactamase inhibitors.
score: 0.16136107, Clinical microbiology reviews, 2010, Drawz, Sarah M; Bonomo, Robert A
Development of predictive in silico model for cyclosporine- and aureobasidin-based P-glycoprotein inhibitors employing receptor surface analysis
score: 0.16116865, Journal of Molecular Graphics and Modelling, 2008, Zalloum, Hiba M.; Taha, Mutasem O.
Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity
score: 0.1610943, European Journal of Medicinal Chemistry, 2001, Quintela, José M et. al.
Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents.
score: 0.16066857, Antimicrobial agents and chemotherapy, 1996, Favre, B; Ryder, N S
Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease
score: 0.15882532, Chemistry & Biology, 2001, Chen, Chien-An et. al.
5′-Peptidyl substituents allow a tuning of the affinity of oligodeoxyribonucleotides for RNA
score: 0.15882093, Bioorganic & Medicinal Chemistry Letters, 1998, Sarracino, David A. et. al.
Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
score: 0.15798898, Chemistry (Weinheim an der Bergstrasse, Germany), 2012, Yang, Peng-Yu et. al.
Comparative complement selection in bacteria enables screening for lead compounds targeted to a purine salvage enzyme of parasites.
score: 0.15771535, Antimicrobial agents and chemotherapy, 1995, Eakin, A E et. al.
The Structure and Mechanism of the Mycobacterium tuberculosis Cyclodityrosine Synthetase
score: 0.15762417, Nature chemical biology, 2010, Vetting, Matthew W.; Hegde, Subray S.; Blanchard, John S.
1-Amino-1-deoxy-d-fructose (“Fructosamine”) and its Derivatives
score: 0.15727483, Advances in Carbohydrate Chemistry and Biochemistry, 2010, Mossine, Valeri V.; Mawhinney, Thomas P.
DOGS: Reaction-Driven de novo Design of Bioactive Compounds
score: 0.15722331, PLoS Computational Biology, 2012, Hartenfeller, Markus et. al.
N 6 -Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO
score: 0.15702334, Nature Chemical Biology, 2011, Jia, Guifang et. al.
Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activities.
score: 0.15625649, Antimicrobial agents and chemotherapy, 1997, Richardson, D R
Chemical synthesis of allysine ethylene acetal and conversion in situ into 1-piperideine-6-carboxylic acid: Key intermediate of the α-aminoadipic acid for β-lactam antibiotics biosynthesis
score: 0.15601822, Bioorganic & Medicinal Chemistry, 1995, Rumbero, Angel et. al.
In vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerations.
score: 0.15558953, Antimicrobial agents and chemotherapy, 1994, Klopman, G et. al.
Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.
score: 0.1555282, Antimicrobial agents and chemotherapy, 1991, Counter, F T et. al.
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
score: 0.15519513, Cell, 2012, Dixon, Scott J. et. al.
CBI-CDPBO 1 and CBI-CDPBI 1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit
score: 0.15450034, Bioorganic & Medicinal Chemistry, 1995, Boger, Dale L.; Yun, Weiya; Cai, Hui; Han, Nianhe
Comparative action of carbocyclic thromboxane A 2 stereoisomers on platelets
score: 0.15387775, European Journal of Medicinal Chemistry, 2000, Caton, Michael P.L. et. al.
Prodrugs of butyric acid. Novel derivatives possessing increased aqueous solubility and potential for treating cancer and blood diseases
score: 0.15333539, European Journal of Medicinal Chemistry, 2001, Nudelman, Abraham et. al.
Iron Traffics in Circulation Bound to a Siderocalin (Ngal)-Catechol Complex
score: 0.15305913, Nature chemical biology, 2010, Bao, Guanhu et. al.
Amides of piperidine, morpholine and piperazine substituted 1-phenylethylamines: Inhibitors of acylCoA:cholesterol acyltransferase (ACAT) activity in vitro and in vivo
score: 0.15279319, Bioorganic & Medicinal Chemistry, 1995, Dugar, Sundeep et. al.
The peptide hormone ghrelin binds to membrane-mimetics via its octanoyl chain and an adjacent phenylalanine
score: 0.15277854, Bioorganic & Medicinal Chemistry, 2010, Großauer, Jörg et. al.
Design, synthesis and antiinflammatory activity of some 1,3,4-oxadiazole derivatives
score: 0.15276336, European Journal of Medicinal Chemistry, 1996, Omar, FA; Mahfouz, NM; Rahman, MA
Active site-directed thrombin inhibitors: α-hydroxyacylprolyl-arginals. New orally active stable analogs of d-Phe-Pro-Arg-H
score: 0.15260889, Bioorganic & Medicinal Chemistry, 1995, Bajusz, S. et. al.
Renal dehydropeptidase-I stability of LJC 10,627, a new carbapenem antibiotic.
score: 0.1516451, Antimicrobial agents and chemotherapy, 1992, Hikida, M et. al.
Development of Novel In Silico Model to Predict Corneal Permeability for Congeneric Drugs: A QSPR Approach
score: 0.1513127, Journal of Biomedicine and Biotechnology, 2011, Sharma, Charu et. al.
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis.
score: 0.15107577, Antimicrobial agents and chemotherapy, 1996, Slayden, R A et. al.
Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD
score: 0.15050612, Chemistry & Biology, 2009, Sorci, Leonardo et. al.
Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria.
score: 0.15000299, Antimicrobial agents and chemotherapy, 1995, Nicas, T I et. al.
Carbohydrate-dependent cell adhesion
score: 0.14981189, Bioorganic & Medicinal Chemistry, 1995, Fukuda, Minoru
Criteria for the mode of binding of DNA binding agents
score: 0.14974108, Bioorganic & Medicinal Chemistry, 1995, Suh, Dongchul; Chaires, Jonathan B.
Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3- dideoxy-3-C- hydroxymethyl-β- d -threo- pentofuranosyl) thymine derivatives
score: 0.14941898, Bioorganic & Medicinal Chemistry, 1995, Wengel, Jesper; Schinazi, Raymond F.; Caruthers, Marvin H.
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors.
score: 0.14913923, Nature chemical biology, 2005, Kagan, Valerian E et. al.
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s.
score: 0.14875599, Nature chemical biology, 2007, Chang, Michelle C Y et. al.
Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.
score: 0.14871627, Antimicrobial agents and chemotherapy, 1995, Nair, V; Jahnke, T S
Triphenylbutanamines:Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity †
score: 0.14818299, Journal of Medicinal Chemistry, 2012, Wang, Fang et. al.
Antitumor agents. Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system
score: 0.14812196, European Journal of Medicinal Chemistry, 2001, Capilla, Alfons Sergi et. al.
Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment.
score: 0.14800597, Nature chemical biology, 2006, Lyubimov, Artem Y et. al.
Perturbations in DNA structure upon interaction with porphyrins revealed by chemical probes, DNA footprinting and molecular modelling
score: 0.1475913, Bioorganic & Medicinal Chemistry, 1995, Ford, Kevin G.; Neidle, Stephen
Comparative in vitro activities of a new quinolone, OPC-17116, possessing potent activity against gram-positive bacteria.
score: 0.14711707, Antimicrobial agents and chemotherapy, 1992, Wakebe, H; Mitsuhashi, S
Oxygen-17 NMR spectroscopy: Basic principles and applications (part II)
score: 0.14698749, Progress in Nuclear Magnetic Resonance Spectroscopy, 2010, Gerothanassis, Ioannis P.
New anti-HIV derivatives: synthesis and antiviral evaluation
score: 0.14654262, Bioorganic & Medicinal Chemistry, 2000, De Michelis, C. et. al.
In vitro activities of ramoplanin, selected glycopeptides, fluoroquinolones, and other antibiotics against clinical bloodstream isolates of gram-positive cocci.
score: 0.14645828, Antimicrobial agents and chemotherapy, 1993, Lawrence, T et. al.
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit
score: 0.14609243, Biochemical Journal, 2010, Blackburn, Christopher et. al.
Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.
score: 0.14591152, Proceedings of the National Academy of Sciences of the United States of America, 2012, Donohoe, Timothy J et. al.
Structure-based combinatorial library design: methodologies and applications
score: 0.14581839, Journal of Molecular Graphics and Modelling, 2002, Beavers, Mary Pat; Chen, Xin
Sequence-specific DNA binding by covalently constrained peptide dimers of the basic leucine zipper protein GCN4
score: 0.14540489, Bioorganic & Medicinal Chemistry, 1995, Okagami, Masako et. al.
Structure-based virtual screening: an overview
score: 0.14510498, Drug Discovery Today, 2002, Lyne, Paul D
Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs
score: 0.14509099, Journal of Hematology & Oncology, 2009, Padhye, Subhash et. al.
Multicomponent reaction design in the quest for molecular complexity and diversity.
score: 0.14502287, Angewandte Chemie (International ed. in English), 2011, Ruijter, Eelco; Scheffelaar, Rachel; Orru, Romano V A
Acetylesterase from orange peel as biocatalyst for the chemo- and regioselective deprotection of carbohydrates
score: 0.14490689, Bioorganic & Medicinal Chemistry, 1994, Waidmann, Herbert; Heuser, Axel
In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin.
score: 0.14442569, Antimicrobial agents and chemotherapy, 1992, Bartizal, K et. al.
Discovery of a novel class of AKT pleckstrin homology domain inhibitors.
score: 0.1443595, Molecular cancer therapeutics, 2008, Mahadevan, Daruka et. al.
Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription.
score: 0.14430272, Antimicrobial agents and chemotherapy, 1996, Arts, E J; Wainberg, M A
Synthesis of a spacer-containing tetrasaccharide representing a repeating unit of the capsular polysaccharide of Streptococcus pneumoniae type 6B
score: 0.14404142, Bioorganic & Medicinal Chemistry, 1994, Thijssen, Mark-J.L. et. al.
Structural and chemical basis for enhanced affinity and potency for a large series of estrogen receptor ligands: 2D and 3D QSAR studies
score: 0.14401588, Journal of Molecular Graphics and Modelling, 2007, Salum, Lívia de B. et. al.
A support vector machines approach for virtual screening of active compounds of single and multiple mechanisms from large libraries at an improved hit-rate and enrichment factor
score: 0.14392722, Journal of Molecular Graphics and Modelling, 2008, Han, L.Y. et. al.
Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency.
score: 0.14378124, ChemMedChem, 2011, Sun, Aiming et. al.
Adenylate kinase release as a high throughput screening compatible reporter of bacterial lysis for the identification of antibacterial agents.
score: 0.14355138, Antimicrobial agents and chemotherapy, 2012, Jacobs, Anna C et. al.
Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors
score: 0.14307593, Journal of Molecular Graphics and Modelling, 2006, Vulpetti, Anna et. al.
Synthesis of novel tripodal-benzimidazole from 2,4,6-tris(p-formylphenoxy)-1,3,5-triazine: Structural, electrochemical and antimicrobial studies
score: 0.14296456, Journal of Hazardous Materials, 2010, Koc, Ziya Erdem et. al.
Emerging classes of protein–protein interaction inhibitors and new tools for their development
score: 0.14214255, Current Opinion in Chemical Biology, 2004, Pagliaro, Len et. al.
Soft drugs—XVI. Design, evaluation and transdermal penetration of novel soft anticholinergics based on methatropine
score: 0.14184948, Bioorganic & Medicinal Chemistry, 1993, Kumar, Gondi N.; Hammer, Richard H.; Bodor, Nicholas S.
Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives
score: 0.14016786, Chemistry Central Journal, 2011, Sundar, Jeyaperumal Kalyana et. al.
Fast rule-based bioactivity prediction using associative classification mining
score: 0.14012203, Journal of Cheminformatics, 2012, Yu, Pulan; Wild, David J
A combined molecular modeling study on gelatinases and their potent inhibitors.
score: 0.13998884, Journal of computational chemistry, 2010, Xi, Lili et. al.
Substrate specificity of Epstein-Barr virus thymidine kinase.
score: 0.13957966, Antimicrobial agents and chemotherapy, 1994, Tung, P P; Summers, W C
Synthesis and activity of 3-pyridylamine ligands at central nicotinic receptors
score: 0.13950762, European Journal of Medicinal Chemistry, 2000, Balboni, Gianfranco et. al.
A Novel Aminoglycoside (2") Phosphotransferase Identified in a Gram-negative Pathogen.
score: 0.13834436, Antimicrobial agents and chemotherapy, 2012, Toth, Marta et. al.
Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.
score: 0.13795083, Proceedings of the National Academy of Sciences of the United States of America, 2010, Choi, Jung-Suk et. al.
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease.
score: 0.13776984, Antimicrobial agents and chemotherapy, 1993, Maldonado, R A; Molina, J; Payares, G; Urbina, J A
Cameroonian Medicinal Plants: Pharmacology and Derived Natural Products
score: 0.137564, Frontiers in Pharmacology, 2010, Kuete, Victor; Efferth, Thomas
Phosphorothioation of DNA in bacteria by dnd genes.
score: 0.13750023, Nature chemical biology, 2007, Wang, Lianrong et. al.
Dimers from dechlorinated rebeccamycin: synthesis, interaction with DNA, and antiproliferative activities
score: 0.13655682, European Journal of Medicinal Chemistry, 2002, Marminon, Christelle et. al.
Cellular QuantitativeStructure–Activity Relationship(Cell-QSAR): Conceptual Dissection of Receptor Binding and IntracellularDisposition in Antifilarial Activities of Selwood Antimycins
score: 0.13651975, Journal of Medicinal Chemistry, 2012, Natesan, Senthil et. al.
Synthesis, biodistribution and PET studies in rats of 18F-labeled bridgehead fluoromethyl analogues of WAY-100635
score: 0.13608594, Nuclear Medicine and Biology, 2012, Al Hussainy, Rana et. al.
Combined Pharmacophore Modeling, Docking, and 3D-QSAR Studies of PLK1 Inhibitors
score: 0.13599109, International Journal of Molecular Sciences, 2011, Lu, Shuai et. al.
Synthesis and evaluation of nitrostyrene derivative compounds, new snake venom phospholipase A 2 inhibitors
score: 0.13577357, Toxicon, 2008, Villar, J.A.F.P. et. al.
Identification of new classes of ricin toxin inhibitors by virtual screening
score: 0.13573889, Toxicon, 2010, Bai, Yan et. al.
Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors
score: 0.13542699, PLoS ONE, 2009, Davies, Matthew N. et. al.
FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.
score: 0.13520692, Nature chemical biology, 2011, Lee, Kyung-Jo et. al.
Combining docking, scoring and molecular field analyses to probe influenza neuraminidase–ligand interactions
score: 0.13484906, Journal of Molecular Graphics and Modelling, 2007, Abu Hammad, Areej M.; Afifi, Fatma U.; Taha, Mutasem O.
Combinatorial profiling of chromatin-binding modules reveals multi-site discrimination
score: 0.13411589, Nature chemical biology, 2009, Garske, Adam L. et. al.
Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors
score: 0.13404959, Archives of Biochemistry and Biophysics, 2004, Suzuki, Hisashi et. al.
Targeting peptide nucleic acid-protein conjugates to structural features within duplex DNA
score: 0.13400631, Bioorganic & Medicinal Chemistry, 1995, Norton, James C. et. al.
Capture and Release of Alkyne-Derivatized Glycerophospholipids Using Cobalt Chemistry
score: 0.1339194, Nature chemical biology, 2009, Milne, Stephen B. et. al.
Binding of 2,4-disubstituted morpholines at human D 4 dopamine receptors
score: 0.13351553, Bioorganic & Medicinal Chemistry, 1998, Showell, Graham A. et. al.
Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.
score: 0.13349669, Antimicrobial agents and chemotherapy, 1992, Schinazi, R F et. al.
Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3 H )-ones
score: 0.13337427, Scientia Pharmaceutica, 2010, Patel, Navin B.; Patel, Jaymin C.
Fragment-based lead discovery: leads by design
score: 0.13263606, Drug Discovery Today, 2005, Carr, Robin A.E. et. al.
2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir.
score: 0.13243978, Antimicrobial agents and chemotherapy, 1993, Hamzeh, F M; Spector, T; Lietman, P S
In vitro activity of the new fluoroquinolone CP-99,219.
score: 0.13217141, Antimicrobial agents and chemotherapy, 1994, Neu, H C; Chin, N X
Oxidative coupling of mithramycin and hydroquinone catalyzed by copper oxidases and benzoquinone. Implications for the mechanism of action of aureolic acid antibiotics
score: 0.13195835, Bioorganic & Medicinal Chemistry, 1994, Anyanwutaku, Innocent O. et. al.
Activity of trovafloxacin (CP-99,219) against Legionella isolates: in vitro activity, intracellular accumulation and killing in macrophages, and pharmacokinetics and treatment of guinea pigs with L. pneumophila pneumonia.
score: 0.13195214, Antimicrobial agents and chemotherapy, 1996, Edelstein, P H et. al.
Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR
score: 0.1312757, PLoS Computational Biology, 2009, Ekins, Sean et. al.
Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation.
score: 0.13098843, Antimicrobial agents and chemotherapy, 1995, Dabbs, E R et. al.
Potentiation of the antimalarial agent rufigallol.
score: 0.13095745, Antimicrobial agents and chemotherapy, 1996, Winter, R W et. al.
Synthesis of cytotoxic novel 9,11-secosterol analogs: Structure/activity studies
score: 0.1306102, Steroids, 2010, Kongkathip, Boonsong et. al.
Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS-NMR.
score: 0.13053974, Nature chemical biology, 2011, Ullrich, Sandra J et. al.
In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor.
score: 0.13048004, Antimicrobial agents and chemotherapy, 1995, Flamm, R K et. al.
Tetrahydronaphthalenic derivatives as new agonist and antagonist ligands for melatonin receptors
score: 0.13040186, Bioorganic & Medicinal Chemistry, 1998, Fourmaintraux, E. et. al.
A convenient synthesis of nucleoside monophosphate- N-acetylneuraminic acids (NMP-Neu5AC)
score: 0.1296245, Bioorganic & Medicinal Chemistry, 1994, Martin, Thomas J.; Braun, Heik; Schmidt, Richard R.
3D-QSAR and Molecular Docking Studies on Derivatives of MK-0457, GSK1070916 and SNS-314 as Inhibitors against Aurora B Kinase
score: 0.12877507, International Journal of Molecular Sciences, 2010, Zhang, Baidong; Li, Yan; Zhang, Huixiao; Ai, Chunzhi
Antibacterial drug discovery and structure-based design
score: 0.12877216, Drug Discovery Today, 2006, Barker, John J.
Synthesis and antibacterial activity of dual-action agents of a β-lactam antibiotic with cytotoxic agent mitozolomide or temozolomide
score: 0.12803889, European Journal of Medicinal Chemistry, 2002, Wang, Yongfeng; Lambert, Peter; Zhao, Linxiang; Wang, Danni
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections.
score: 0.12790765, Antimicrobial agents and chemotherapy, 1996, Ford, C W et. al.
Synthesis and α-adrenoreceptor blocking properties of phenoxybenzamine-related (2-chloroethyl)-(2,3-dihydrobenzo-[1,4]dioxin-2-ylmethyl)-(2-phenoxyethyl) amines
score: 0.12775595, Bioorganic & Medicinal Chemistry, 1995, Giardinà, Dario et. al.
Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).
score: 0.1277483, ChemMedChem, 2010, Castellano, Sabrina et. al.
Use of intravenous rifampin in neonates with persistent staphylococcal bacteremia.
score: 0.12725511, Antimicrobial agents and chemotherapy, 1993, Tan, T Q; Mason, E O; Ou, C N; Kaplan, S L
Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) Studies on α 1A -Adrenergic Receptor Antagonists Based on Pharmacophore Molecular Alignment
score: 0.12707955, International Journal of Molecular Sciences, 2011, Zhao, Xin; Chen, Minsheng; Huang, Biyun; Ji, Hong; Yuan, Mu
Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice.
score: 0.12703605, Antimicrobial agents and chemotherapy, 1994, Smee, D F; Sugiyama, S T; Reist, E J
Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.
score: 0.12696542, Molecular cancer therapeutics, 2003, Yoon, Kyoung Jin P et. al.
Antagonists of protein–protein interactions
score: 0.12592, Chemistry & Biology, 2000, Cochran, Andrea G
Antiviral properties of palinavir, a potent inhibitor of the human immunodeficiency virus type 1 protease.
score: 0.12585074, Antimicrobial agents and chemotherapy, 1997, Lamarre, D et. al.
Structural Determination of Three Different Series of Compounds as Hsp90 Inhibitors Using 3D-QSAR Modeling, Molecular Docking and Molecular Dynamics Methods
score: 0.12555171, International Journal of Molecular Sciences, 2011, Liu, Jianling et. al.
Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination.
score: 0.12554953, Nature chemical biology, 2005, Ghosh, Kaushik et. al.
Synthesis of (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties
score: 0.12545535, European Journal of Medicinal Chemistry, 2000, Wichmann, Jürgen et. al.
Molecular associations of flavins with betacarbolines and related indoles
score: 0.12517575, Bioorganic & Medicinal Chemistry, 1995, Muñoz, Maria A et. al.
Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity.
score: 0.125136, Antimicrobial agents and chemotherapy, 1997, Steinberg, D A et. al.
In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand.
score: 0.1250934, Antimicrobial agents and chemotherapy, 1997, Edstein, M D et. al.
Discovery of new potent human protein tyrosine phosphatase inhibitors via pharmacophore and QSAR analysis followed by in silico screening
score: 0.12493545, Journal of Molecular Graphics and Modelling, 2007, Taha, Mutasem O. et. al.
Detection of extended-spectrum beta-lactamases in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes.
score: 0.12475937, Journal of clinical microbiology, 2000, Tzelepi, E et. al.
Research on the structure–surface adsorptive activity relationships of triazolyl glycolipid derivatives for mild steel in HCl
score: 0.12473931, Carbohydrate Research, 2012, Zhang, Hai-Lin et. al.
Research on the structure–surface adsorptive activity relationships of triazolyl glycolipid derivatives for mild steel in HCl
score: 0.12473931, Carbohydrate Research, 2012, Zhang, Hai-Lin et. al.
Research on the structure–surface adsorptive activity relationships of triazolyl glycolipid derivatives for mild steel in HCl
score: 0.12473931, Carbohydrate Research, 2012, Zhang, Hai-Lin et. al.
Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes.
score: 0.12366773, Nature chemical biology, 2006, Ramazzina, Ileana et. al.
A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors.
score: 0.12351233, Molecular pharmacology, 2008, Liang, Hong; Wu, Xing; Yalowich, Jack C; Hasinoff, Brian B
Aminotransferase catalysis applied to the synthesis of a PAF antagonist
score: 0.12347467, Bioorganic & Medicinal Chemistry, 1994, Coffen, David L. et. al.
Natural compounds as a source of protein tyrosine phosphatase inhibitors: Application to the rational design of small-molecule derivatives
score: 0.12344896, Biochimie, 2006, Ferreira, Carmen V. et. al.
Further investigation of anticoccidial activity of 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine.
score: 0.12310211, Antimicrobial agents and chemotherapy, 1992, Ricketts, A P et. al.
Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme.
score: 0.12211866, Nature chemical biology, 2009, Liu, Lu et. al.
Increase of leishmanicidal and tubercular activities using steroids linked to aminoquinoline
score: 0.12207183, Organic and Medicinal Chemistry Letters, 2012, Antinarelli, Luciana MR et. al.
An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1
score: 0.12066616, Parasitology Research, 2009, Singh, Neeloo et. al.
The significance of G protein-coupled receptor crystallography for drug discovery.
score: 0.12025569, Pharmacological reviews, 2011, Salon, John A; Lodowski, David T; Palczewski, Krzysztof
In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides.
score: 0.12010313, Antimicrobial agents and chemotherapy, 1997, Bacchi, C J et. al.
In vitro activity of BMS-181139, a new carbapenem with potent antipseudomonal activity.
score: 0.11984211, Antimicrobial agents and chemotherapy, 1995, Kessler, R E et. al.
Rational Approaches toImproving Selectivityin Drug Design
score: 0.11960913, Journal of Medicinal Chemistry, 2012, Huggins, David J.; Sherman, Woody; Tidor, Bruce
Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin
score: 0.1186981, European Journal of Medicinal Chemistry, 2011, Varbanov, Hristo et. al.
Pharmacophore Selection and Redesign of Non-nucleotide Inhibitors of Anthrax Edema Factor
score: 0.1184559, Toxins, 2012, Schein, Catherine H. et. al.
Biological characterization of cyclothialidine, a new DNA gyrase inhibitor.
score: 0.11739256, Antimicrobial agents and chemotherapy, 1993, Nakada, N et. al.
A biomimetic domino reaction for the concise synthesis of capreomycidine and epicapreomycidine
score: 0.11715197, Amino Acids, 2012, Büschleb, Martin et. al.
In vitro activity and in vivo efficacy of a new series of 9-deoxo-12-deoxy-9,12-epoxyerythromycin A derivatives.
score: 0.11609645, Antimicrobial agents and chemotherapy, 1991, Hardy, D J et. al.
Chemical substructures that enrich for biological activity
score: 0.11601433, Bioinformatics, 2008, Klekota, Justin; Roth, Frederick P.
Synthesis and anti-microbial activities of some pyridinium salts with alkoxymethyl hydrophobic group
score: 0.11549077, European Journal of Medicinal Chemistry, 2001, Pernak, Juliusz et. al.
Prolyl cis-trans isomerization as a molecular timer.
score: 0.11535686, Nature chemical biology, 2007, Lu, Kun Ping; Finn, Greg; Lee, Tae Ho; Nicholson, Linda K
Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin
score: 0.11492895, Bioorganic Chemistry, 2013, Cloete, Theunis T. et. al.
Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin
score: 0.11492895, Bioorganic Chemistry, 2013, Cloete, Theunis T. et. al.
Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors
score: 0.11482664, Journal of Molecular Graphics and Modelling, 2007, Bharatham, Nagakumar; Bharatham, Kavitha; Lee, Keun Woo
A fluorescence polarization assay for inhibitors of Hsp90
score: 0.11462691, Analytical Biochemistry, 2006, Howes, R. et. al.
Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and of their constrained analogue imidazo[1,5-a]quinoxaline-1,3,4-triones as glycine/NMDA receptor antagonists
score: 0.11444455, European Journal of Medicinal Chemistry, 2001, Varano, Flavia et. al.
Kinetics and mechanism of general acid-catalysed thiolytic cleavage of 9-anilinoacridine
score: 0.11410106, Bioorganic & Medicinal Chemistry, 1995, Khan, M.Niyaz; Kuliya-Umar, A.F.
SIB-DOTA: A trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies
score: 0.11347806, Bioorganic & Medicinal Chemistry, 2012, Vaidyanathan, G. et. al.
SIB-DOTA: A trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies
score: 0.11347806, Bioorganic & Medicinal Chemistry, 2012, Vaidyanathan, G. et. al.
SIB-DOTA: A trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies
score: 0.11347806, Bioorganic & Medicinal Chemistry, 2012, Vaidyanathan, G. et. al.
A torque component in the kinesin-1 power stroke.
score: 0.11346045, Nature chemical biology, 2005, Yajima, Junichiro; Cross, Robert A
'Turning on' riboswitches to their antibacterial potential.
score: 0.11338821, Nature chemical biology, 2007, Lea, Charles R; Piccirilli, Joseph A
Anti-human immunodeficiency virus activity of a novel synthetic peptide, T22 ([Tyr-5,12, Lys-7]polyphemusin II): a possible inhibitor of virus-cell fusion.
score: 0.11337223, Antimicrobial agents and chemotherapy, 1992, Nakashima, H et. al.
Epoxidation of styrene and substituted styrenes by whole cells of mycobacterium sp. M156
score: 0.11298154, Bioorganic & Medicinal Chemistry, 1994, Rigby, Stuart R.; Matthews, Colette S.; Leak, David J.
The identification of cutin synthase: formation of the plant polyester cutin
score: 0.11264209, Nature chemical biology, 2012, Yeats, Trevor H. et. al.
Strigolactone analogs as molecular probes in chasing the (SLs) receptor/s: design and synthesis of fluorescent labeled molecules.
score: 0.11232425, Molecular plant, 2013, Prandi, Cristina et. al.
On the conformation of Phe78 of a chromoprotein antibiotic, neocarzinostatin
score: 0.11207657, Bioorganic & Medicinal Chemistry, 1995, Imajo, Seiichi et. al.
In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria.
score: 0.11168169, Antimicrobial agents and chemotherapy, 1997, Franssen, F F et. al.
ChEMBL: a large-scale bioactivity database for drug discovery
score: 0.11149672, Nucleic Acids Research, 2011, Gaulton, Anna et. al.
Combining docking and molecular dynamic simulations in drug design.
score: 0.11130189, Medicinal research reviews, 2006, Alonso, Hernán; Bliznyuk, Andrey A; Gready, Jill E
A synthesis of ( R-recifeiolide by the aid of biochemical reaction as the key-step
score: 0.11129632, Bioorganic & Medicinal Chemistry, 1993, Mochizuki, Naoki et. al.
Combined chemical and enzymatic synthesis of the sialylated non reducing terminal sequence of GM1 b glycolylated ganglioside, a potential human tumor marker
score: 0.11089155, Bioorganic & Medicinal Chemistry, 1994, Lubineau, André et. al.
Design of silicon-based misonidazole analogues and 18F-radiolabelling
score: 0.11031577, Nuclear Medicine and Biology, 2009, Bohn, Pierre et. al.
Differentiating Alzheimer disease-associated aggregates with small molecules
score: 0.11007802, Neurobiology of Disease, 2007, Honson, Nicolette S. et. al.
Design of dimeric peptides obtained from a subdominant Epstein-Barr virus LMP2-derived epitope
score: 0.10988252, European Journal of Medicinal Chemistry, 2000, Marastoni, Mauro et. al.
Differential Binding of Inhibitors to Active and Inactive CDK2 Provides Insights for Drug Design
score: 0.10886346, Chemistry & Biology, 2006, Kontopidis, George et. al.
Combinatorial profiling of chromatin binding modules reveals multisite discrimination.
score: 0.10882089, Nature chemical biology, 2010, Garske, Adam L et. al.
In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone.
score: 0.10867826, Antimicrobial agents and chemotherapy, 1992, Hosaka, M et. al.
Complete template-directed enzymatic synthesis of a potential antisense DNA containing 42 methylphosphonodiester bonds
score: 0.10831417, Bioorganic & Medicinal Chemistry, 1993, Dineva, M.A. et. al.
Chemical mechanisms underlying the vasodilator and platelet anti-aggregating properties of S-nitroso- N-acetyl- dl-penicillamine and S-nitrosoglutathione
score: 0.10814742, Bioorganic & Medicinal Chemistry, 1995, Askew, Stuart C. et. al.
Molecular mechanics and dynamics studies on two structurally related amide-modified DNA backbones for antisense technology
score: 0.10803986, Bioorganic & Medicinal Chemistry, 1995, Fritsch, Valérie et. al.
GES-18, a new carbapenem-hydrolyzing GES-type β-lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues.
score: 0.1059646, Antimicrobial agents and chemotherapy, 2012, Bebrone, Carine et. al.
Anti-Mycobacterium avium activity of quinolones: in vitro activities.
score: 0.10596296, Antimicrobial agents and chemotherapy, 1993, Klopman, G et. al.
Labdane-type diterpenoids from hairy root cultures of Coleus forskohlii, possible intermediates in the biosynthesis of forskolin
score: 0.10504177, Phytochemistry, 2012, Asada, Yoshihisa et. al.
Labdane-type diterpenoids from hairy root cultures of Coleus forskohlii, possible intermediates in the biosynthesis of forskolin
score: 0.10504177, Phytochemistry, 2012, Asada, Yoshihisa et. al.
Enhancement of bismuth antibacterial activity with lipophilic thiol chelators.
score: 0.10499635, Antimicrobial agents and chemotherapy, 1997, Domenico, P et. al.
Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents
score: 0.10496968, Marine Drugs, 2011, Shen, Ya-Ching et. al.
Novel antagonists of the thioesterase domain of human fatty acid synthase.
score: 0.1042434, Molecular cancer therapeutics, 2007, Richardson, Robyn D; Smith, Jeffrey W
Development of a dual cell, flow-injection sample holder, and NMR probe for comparative ligand-binding studies
score: 0.10403777, Journal of Magnetic Resonance, 2006, Marquardsen, Thorsten et. al.
How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?
score: 0.10402078, Malaria Journal, 2011, Guantai, Eric; Chibale, Kelly
Structural basis for regulation of the Crk signaling protein by a proline switch
score: 0.10387416, Nature chemical biology, 2010, Sarkar, Paramita et. al.
Rapid and orthogonal logic gating with a gibberellin-induced dimerization system.
score: 0.10367502, Nature chemical biology, 2012, Miyamoto, Takafumi et. al.
Zinc Availability Regulates Exit from Meiosis in Maturing Mammalian Oocytes
score: 0.10327574, Nature chemical biology, 2010, Kim, Alison M. et. al.
Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)
score: 0.10307212, PLoS ONE, 2012, Spadaro, Alessandro et. al.
An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line
score: 0.10269592, Chemistry & Biology, 2006, Gutierrez, Jemy A. et. al.
Computational tools for structure-based ligand design
score: 0.102551, Progress in Biophysics and Molecular Biology, 1996, Böhm, Hans-Joachim
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.
score: 0.10215109, Molecular cancer therapeutics, 2008, Woo, L W Lawrence et. al.
Antimicrobial activity and spectrum of LB20304, a novel fluoronaphthyridone.
score: 0.10187781, Antimicrobial agents and chemotherapy, 1997, Cormican, M G; Jones, R N
Genome instability due to ribonucleotide incorporation into DNA
score: 0.1011119, Nature chemical biology, 2010, Nick McElhinny, Stephanie A. et. al.
Structure-based 3D-QSAR models and dynamics analysis of novel N-benzyl pyridinone as p38α MAP kinase inhibitors for anticytokine activity
score: 0.10103279, Journal of Molecular Graphics and Modelling, 2012, Ul-Haq, Zaheer et. al.
Structure-based 3D-QSAR models and dynamics analysis of novel N-benzyl pyridinone as p38α MAP kinase inhibitors for anticytokine activity
score: 0.10103279, Journal of Molecular Graphics and Modelling, 2012, Ul-Haq, Zaheer et. al.
WITHDRAWN: Very strong synergy between modified RANTES and gp41 binding peptides leads to potent anti-HIV-1 activity.
score: 0.10091606, Antimicrobial agents and chemotherapy, 2009, Jin, Hongjun et. al.
Differences in the resistant variants of Enterobacter cloacae selected by extended-spectrum cephalosporins.
score: 0.10062592, Antimicrobial agents and chemotherapy, 1996, Fung-Tomc, J C et. al.
NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic.
score: 0.10047541, Nature chemical biology, 2011, Barb, Adam W; Prestegard, James H
The exploration of macrocycles for drug discovery--an underexploited structural class.
score: 0.099976149, Nature reviews. Drug discovery, 2008, Driggers, Edward M et. al.
In vitro activity of the tribactam GV104326 against gram-positive, gram-negative, and anaerobic bacteria.
score: 0.099762223, Antimicrobial agents and chemotherapy, 1994, Di Modugno, E et. al.
Synergistic activity of 5-trifluoromethylthioribose and inhibitors of methionine synthesis against Klebsiella pneumoniae.
score: 0.0988993, Antimicrobial agents and chemotherapy, 1991, Tower, P A et. al.
Retraction notice to “Proton-pumping-ATPase-targeted antifungal activity of cinnamaldehyde based sulfonyl tetrazoles” [Eur. J. Med. Chem. 48 (2012) 363–370]
score: 0.098865932, European Journal of Medicinal Chemistry, 2012, Shreaz, Sheikh et. al.
Synthesis and Antimicrobial Evaluation of Dibenzo[ b , e ]oxepin-11(6 H )-one O -Benzoyloxime Derivatives
score: 0.098135024, Scientia Pharmaceutica, 2011, Sadek, Bassem et. al.
Activity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin.
score: 0.097819516, Antimicrobial agents and chemotherapy, 1991, Niu, W W; Neu, H C
Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.
score: 0.097792914, Molecular pharmacology, 2008, Raccor, Brianne S et. al.
Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease.
score: 0.09771542, Antimicrobial agents and chemotherapy, 1991, Kempf, D J et. al.
Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region.
score: 0.097154948, Antimicrobial agents and chemotherapy, 1993, Azad, R F et. al.
Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.
score: 0.09707794, Antimicrobial agents and chemotherapy, 1994, Kurtz, M B et. al.
Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones
score: 0.096133296, European Journal of Medicinal Chemistry, 2002, Yogeeswari, Perumal et. al.
Mono-THF ring annonaceous acetogenins from Annona squamosa
score: 0.096015989, Phytochemistry, 1998, Hopp, D.Craig et. al.
Biotransformation of organic sulfides-IV. Formation of chiral benzyl alkyl and phenyl alkyl sulfoxides by Helminthosporium species NRRL 4671
score: 0.095869351, Bioorganic & Medicinal Chemistry, 1994, Holland, Herbert L.; Brown, Frances M.; Larsen, Brett G.
Hammerhead: fast, fully automated docking of flexible ligands to protein binding sites
score: 0.095710371, Chemistry & Biology, 1996, Welch, William; Ruppert, Jim; Jain, Ajay N.
Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.
score: 0.095675375, Antimicrobial agents and chemotherapy, 1996, Rusconi, S et. al.
Synthesis and antifibrillatory activity of nibentan and its analogues
score: 0.095605215, European Journal of Medicinal Chemistry, 2000, Davydova, Nadejda K et. al.
The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.
score: 0.095535269, Antimicrobial agents and chemotherapy, 1993, Wilson, J E et. al.
Selective leishmanicidal effect of 1,3,4-thiadiazole derivatives and possible mechanism of action against Leishmania species
score: 0.095278507, Experimental Parasitology, 2009, Poorrajab, Fatemeh et. al.
Antiviral effect in human cytomegalovirus-infected cells, pharmacokinetics, and intravitreal toxicology in rabbits of acyclovir diphosphate dimyristoylglycerol.
score: 0.094771174, Antimicrobial agents and chemotherapy, 1995, Shakiba, S et. al.
Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class
score: 0.094583151, Bioorganic & Medicinal Chemistry, 1997, Rohet, Florence et. al.
Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells.
score: 0.094495289, Oncogene, 2012, Bulut, G et. al.
High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv
score: 0.094321728, Tuberculosis, 2012, Reynolds, Robert C. et. al.
In vitro activity of levofloxacin, singly and in combination with rifamycin analogs, against Mycobacterium leprae.
score: 0.094187065, Antimicrobial agents and chemotherapy, 1995, Dhople, A M; Ibanez, M A
Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii.
score: 0.093906255, Antimicrobial agents and chemotherapy, 1997, Urbina, J A et. al.
The ligational behavior of a phenolic quinolyl hydrazone towards copper(II)- ions
score: 0.09357936, Chemistry Central Journal, 2011, Seleem, Hussein S et. al.
Cloning, overexpression and isolation of the type II FDP aldolase from E. coli for specificity study and synthetic application
score: 0.093483993, Bioorganic & Medicinal Chemistry, 1994, Henderson, I. et. al.
Palladium(II) complexes of NS donor ligandsderived from S-methyl-dithiocarbazate, S-benzyldithiocarbazateand thiosemicarbazide as antiamoebic agents
score: 0.09311219, European Journal of Medicinal Chemistry, 2000, Neelam, Bharti et. al.
Increased production of penicillin-binding protein 2, increased detection of other penicillin-binding proteins, and decreased coagulase activity associated with glycopeptide resistance in Staphylococcus aureus.
score: 0.092415558, Antimicrobial agents and chemotherapy, 1997, Moreira, B; Boyle-Vavra, S; deJonge, B L; Daum, R S
Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties
score: 0.09241253, Biochemical and Biophysical Research Communications, 2005, Choudhary, M. Iqbal et. al.
Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides
score: 0.092196825, Bioorganic & Medicinal Chemistry, 1994, Lee, Thomas Tung-Ying et. al.
Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as potential adenosine receptor antagonists
score: 0.092152334, Il Farmaco, 2005, Pastorin, Giorgia et. al.
Synthesis and properties of a hoechst-like minor-groove binding agent tethered to an oligodeoxynucleotide
score: 0.091920874, Bioorganic & Medicinal Chemistry, 1995, O'Donnell, Maryanne J. et. al.
Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.
score: 0.091868609, Antimicrobial agents and chemotherapy, 1994, Chen, M et. al.
A neural networks-based drug discovery approach and its application for designing aldose reductase inhibitors
score: 0.091830866, Journal of Molecular Graphics and Modelling, 2006, Hu, LiHong; Chen, GuanHua; Chau, Raymond Ming-Wah
Discovery of a natural product Inhibitor targeting protein neddylation by structure-based virtual screening
score: 0.091484387, Biochimie, 2012, Zhong, Hai-Jing et. al.
Polyclonal antibodies and catalysis
score: 0.091452978, Bioorganic & Medicinal Chemistry, 1994, Stephens, David B.; Wilmore, Britta H.; Iverson, Brent L.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
score: 0.091039207, Antimicrobial agents and chemotherapy, 1997, Nüesch-Inderbinen, M T; Kayser, F H; Hächler, H
Potent estrogen agonists based on carborane as a hydrophobic skeletal structure
score: 0.090963006, Chemistry & Biology, 2001, Endo, Yasuyuki et. al.
Efficient and highly stereoselective synthesis of a β-Lactam inhibitor of the serine protease prostate-specific antigen
score: 0.090717361, Bioorganic & Medicinal Chemistry, 2002, Annunziata, Rita et. al.
3D-QSAR and molecular docking studies on 3-anilino-4-arylmaleimide derivatives as glycogen synthase kinase-3β inhibitors.
score: 0.090669228, Chemical biology & drug design, 2012, Akhtar, Mymoona; Bharatam, Prasad V
Synthesis of active nitroguaiacol ether derivatives of streptomycin.
score: 0.090589478, Antimicrobial agents and chemotherapy, 1990, Abad, J P; Amils, R
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.
score: 0.090515927, Proceedings of the National Academy of Sciences of the United States of America, 2010, Clemons, Paul A et. al.
Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice.
score: 0.090341908, Proceedings of the National Academy of Sciences of the United States of America, 2012, Sun, Hongmin et. al.
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids.
score: 0.09018902, Antimicrobial agents and chemotherapy, 1994, Marshall, S J et. al.
Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands.
score: 0.090118743, Proceedings of the National Academy of Sciences of the United States of America, 2011, Frankowski, Kevin J et. al.
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.
score: 0.089976406, Molecular cancer therapeutics, 2004, Hamdouchi, Chafiq et. al.
CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity.
score: 0.089830463, Antimicrobial agents and chemotherapy, 1993, Alteri, E et. al.
Virtual screening to enrich a compound collection with CDK2 inhibitors using docking, scoring, and composite scoring models.
score: 0.089640121, Proteins, 2005, Cotesta, Simona et. al.
Unraveling a molecular target of macrolides.
score: 0.089270137, Nature chemical biology, 2008, Altmann, Karl-Heinz; Carreira, Erick M
SB 205952, a novel semisynthetic monic acid analog with at least two modes of action.
score: 0.088843614, Antimicrobial agents and chemotherapy, 1995, Wilson, J M; Oliva, B; Cassels, R; O'Hanlon, P J; Chopra, I
Activity of new quinolones against ciprofloxacin-resistant staphylococci.
score: 0.088727833, Antimicrobial agents and chemotherapy, 1991, Forstall, G J; Knapp, C C; Washington, J A
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
score: 0.088682356, ChemMedChem, 2008, Familiar, Olga et. al.
A web-based platform for virtual screening
score: 0.088674524, Journal of Molecular Graphics and Modelling, 2003, Watson, Paul; Verdonk, Marcel; Hartshorn, Michael J.
In vitro activity of sparfloxacin (CI-978; AT-4140) against clinical isolates from cancer patients.
score: 0.088361184, Antimicrobial agents and chemotherapy, 1990, Rolston, K V et. al.
DG-AMMOS: A New tool to generate 3D conformation of small molecules using D istance G eometry and A utomated M olecular M echanics O ptimization for in silico S creening
score: 0.088039605, BMC Chemical Biology, 2009, Lagorce, David et. al.
Effects of chirality and substituents at carbon 3 in dihydroxyacetone-phosphate analogues on their binding to Rabbit muscle aldolase
score: 0.088002673, Bioorganic & Medicinal Chemistry, 1995, Blonski, C.; Gefflaut, T.; Perie, J.
Molecular basis for sequence selective DNA alkylation by (+)- and ent-(−)-CC-1065 and related agents: Alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity
score: 0.086766444, Bioorganic & Medicinal Chemistry, 1994, Boger, Dale L. et. al.
Synthesis of indolizine derivatives with selective antibacterial activity against Mycobacterium tuberculosis
score: 0.086677827, European Journal of Pharmaceutical Sciences, 2007, Gundersen, Lise-Lotte et. al.
In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.
score: 0.086517087, Antimicrobial agents and chemotherapy, 1993, Nakagawa, S et. al.
Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists
score: 0.086367799, Bioorganic & Medicinal Chemistry, 1997, Todeschi, Nathalie et. al.
Annojahnin from Annona jahnii: a possible precursor of mono-tetrahydrofuran acetogenins
score: 0.085759786, Phytochemistry, 1998, Colman-Saizarbitoria, T et. al.
Recent applications of protein crystallography and structure-guided drug design
score: 0.085668018, Current Opinion in Chemical Biology, 2005, Williams, Shawn P; Kuyper, Lee F; Pearce, Kenneth H
Labdane-type diterpenoids from hairy root cultures of Coleus forskohlii, possible intermediates in the biosynthesis of forskolin
score: 0.085347644, Phytochemistry, 2012, Asada, Yoshihisa et. al.
Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.
score: 0.085278288, Antimicrobial agents and chemotherapy, 1995, Hong, Y L; Hossler, P A; Calhoun, D H; Meshnick, S R
Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
score: 0.085081753, Antimicrobial agents and chemotherapy, 1994, Coutaux, A F; Mooney, J J; Wirth, D F
Genome instability due to ribonucleotide incorporation into DNA.
score: 0.08462292, Nature chemical biology, 2010, Nick McElhinny, Stephanie A et. al.
The specific inhibition of crystal growth of monohydrogen potassium L-tartrate by d-catechin
score: 0.084592389, Bioorganic & Medicinal Chemistry, 1994, Imajo, Seiichi et. al.
Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains.
score: 0.084540132, Antimicrobial agents and chemotherapy, 1995, Balzarini, J; Baba, M; De Clercq, E
Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor
score: 0.084109804, Journal of Thrombosis and Thrombolysis, 2011, Wong, Pancras C.; Pinto, Donald J. P.; Zhang, Donglu
In vitro susceptibilities of Plasmodium falciparum to compounds which inhibit nucleotide metabolism.
score: 0.083973697, Antimicrobial agents and chemotherapy, 1990, Queen, S A; Jagt, D L; Reyes, P
Synergistic inhibition of human immunodeficiency virus isolates (including 3'-azido-3'-deoxythymidine-resistant isolates) by foscarnet in combination with 2',3'-dideoxyinosine or 2',3'-dideoxycytidine.
score: 0.083214273, Antimicrobial agents and chemotherapy, 1996, Palmer, S; Harmenberg, J; Cox, S
Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site.
score: 0.082360207, Chembiochem : a European journal of chemical biology, 2003, Vourloumis, Dionisios et. al.
Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform
score: 0.082277115, Nucleic Acids Research, 2009, Holt, Patrick A. et. al.
CoMFA and CoMSIA 3D-QSAR analysis of DMDP derivatives as anti-cancer agents
score: 0.081873014, Bioinformation, 2008, Srivastava, Vivek et. al.
Orally Bioavailable β3-Adrenergic Receptor Agonists as Potential Therapeutic Agents for Obesityand Type-II Diabetes
score: 0.081851915, Progress in Medicinal Chemistry, 2003, Hu, Baihua; Jennings, Lee L
Identification, Designand Biological Evaluationof Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
score: 0.081829745, Journal of Medicinal Chemistry, 2012, Pidathala, Chandrakala et. al.
Studies on protein kinase C inhibitors; Structure—activity relationships in indolocarbazole and bis-indole series
score: 0.08181669, Bioorganic & Medicinal Chemistry, 1993, Fabre, Serge; Prudhomme, Michelle; Rapp, Maryse
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.
score: 0.081815403, Nature reviews. Drug discovery, 2004, Arkin, Michelle R; Wells, James A
Calculated conformations of sialyl-Le x- and sialyl-Le a-lactones
score: 0.081787717, Bioorganic & Medicinal Chemistry, 1994, Ellervik, Ulf; Magnusson, Göran
Antibacterial activity in bovine lactoferrin-derived peptides.
score: 0.081570829, Antimicrobial agents and chemotherapy, 1997, Hoek, K S; Milne, J M; Grieve, P A; Dionysius, D A; Smith, R
Efficient and stereodivergent synthesis of deoxyimino sugars
score: 0.081447803, Carbohydrate Research, 2005, Hong, Bor-Cherng et. al.
Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9
score: 0.081342823, BMC Cancer, 2011, Boston, Sarice R et. al.
Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams.
score: 0.081292523, Antimicrobial agents and chemotherapy, 1995, Vakulenko, S B; Tóth, M; Taibi, P; Mobashery, S; Lerner, S A
Cloning and nucleotide sequence of the DNA gyrase gyrA gene from the fish pathogen Aeromonas salmonicida.
score: 0.081100776, Antimicrobial agents and chemotherapy, 1996, Oppegaard, H; Sørum, H
Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screening.
score: 0.081009101, ChemMedChem, 2008, Park, Hwangseo et. al.
Antiviral activity of the products of cyclization of dimethyl 2-[(1-arylamino-1-arylmethylidene)hydrazono]succinate
score: 0.080412605, European Journal of Medicinal Chemistry, 2001, Modzelewska-Banachiewicz, Bożena; Kamińska, Teresa
Temperature-dependent in vitro antimicrobial activity of four 4-quinolones and oxytetracycline against bacteria pathogenic to fish.
score: 0.08020299, Antimicrobial agents and chemotherapy, 1992, Martinsen, B; Oppegaard, H; Wichstrøm, R; Myhr, E
Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX.
score: 0.08002214, Nature chemical biology, 2005, Okada, Masahiro et. al.
Comparative Structuraland Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrileCDK9 Inhibitors Suggest the Basis for Isotype Selectivity
score: 0.079844872, Journal of Medicinal Chemistry, 2012, Hole, Alison J. et. al.
Carbohydrate structures of recombmant soluble lamp-1 and leukosialin containing sialyl Le x terminus
score: 0.079625783, Bioorganic & Medicinal Chemistry, 1994, Sueyoshi, Shinobu; Sawada, Ritsuko; Fukuda, Minoru
Inhibition of HIV-1 integrase-catalysed reaction by new DNA minor groove ligands: the oligo-1,3-thiazolecarboxamide derivatives
score: 0.079101349, European Journal of Medicinal Chemistry, 2000, Ryabinin, Vladimir A. et. al.
Design, Synthesis, and Pharmacological Evaluation of Haloperidol Derivatives as Novel Potent Calcium Channel Blockers with Vasodilator Activity
score: 0.0790363, PLoS ONE, 2011, Chen, Yicun et. al.
Efficacies of ABT-719 and related 2-pyridones, members of a new class of antibacterial agents, against experimental bacterial infections.
score: 0.078863716, Antimicrobial agents and chemotherapy, 1995, Alder, J et. al.
CoMSIA study on substituted aryl alkanoic acid analogs as GPR40 agonists.
score: 0.078553594, Chemical biology & drug design, 2011, Bhatt, Aaditya et. al.
An integrated approach to the ligand binding specificity ofNeisseria meningitidisM1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling
score: 0.078413632, Biochimie, 2013, Węglarz-Tomczak, Ewelina et. al.
NMR Structure of d(CGCA 3T 3GCG) 2: Trenmicrogonotropen-b:Zn(II) complex and solution studies of metal ion complexes of tren-microgonotropen-b interacting with DNA
score: 0.078375024, Bioorganic & Medicinal Chemistry, 1995,
Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.
score: 0.078098625, Antimicrobial agents and chemotherapy, 1994, Nakada, N; Gmünder, H; Hirata, T; Arisawa, M
Antimicrobial susceptibilities of Campylobacter jejuni and Campylobacter coli to 12 beta-lactam agents and combinations with beta-lactamase inhibitors.
score: 0.077827571, Antimicrobial agents and chemotherapy, 1996, Tajada, P et. al.
Structural requirements of tetracycline-Tet repressor interaction: determination of equilibrium binding constants for tetracycline analogs with the Tet repressor.
score: 0.077608253, Antimicrobial agents and chemotherapy, 1991, Degenkolb, J; Takahashi, M; Ellestad, G A; Hillen, W
Structure-based design of molecular cancer therapeutics
score: 0.077490325, Trends in Biotechnology, 2009, van Montfort, Rob L.M.; Workman, Paul
Troubleshooting computational methods in drug discovery
score: 0.077445628, Journal of Pharmacological and Toxicological Methods, 2010, Kortagere, Sandhya; Ekins, Sean
Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase
score: 0.077171669, Carbohydrate Research, 2009, Cheng, Keguang et. al.
Dual-action inhibitors of proteolytic enzymes: potential therapeutic agents for cystic fibrosis and related ailments
score: 0.077044607, Bioorganic & Medicinal Chemistry, 1993, Groutas, William C. et. al.
Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins.
score: 0.076915841, Antimicrobial agents and chemotherapy, 1993, Arlet, G et. al.
Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, β-galactoside α2,6-sialyltransferase cDNA
score: 0.076473825, Bioorganic & Medicinal Chemistry, 1993, Hamamoto, Toshiro et. al.
Divergence of multimodular polyketide synthases revealed by a didomain structure
score: 0.076277213, Nature chemical biology, 2012, Zheng, Jianting et. al.
Natural anti-HIV agents—part I: (+)-demethoxyepiexcelsin and verticillatol from Litsea verticillata
score: 0.076133119, Phytochemistry, 2002, Hoang, Vu Dinh et. al.
N-1-tert-butyl-substituted quinolones: in vitro anti-Mycobacterium avium activities and structure-activity relationship studies.
score: 0.076072925, Antimicrobial agents and chemotherapy, 1996, Klopman, G; Fercu, D; Renau, T E; Jacobs, M R
Chemoenzymatic access to enantiomeric bicyclo[2.2.1]heptan-2,5-diones
score: 0.075848835, Bioorganic & Medicinal Chemistry, 1994, Weissfloch, Alexandra; Azerad, Robert
Docking and chemoinformatic screens for new ligands and targets
score: 0.075522749, Current Opinion in Biotechnology, 2009, Kolb, Peter et. al.
N-Pyridinyl-indole-3-(alkyl)carboxamides and derivatives as potential systemic and topical inflammation inhibitors
score: 0.075487139, European Journal of Medicinal Chemistry, 2001, Duflos, Muriel et. al.
Development of QSAR model for immunomodulatory activity of natural coumarinolignoids
score: 0.075263886, Drug Design, Development and Therapy, 2010, Yadav, Dharmendra K et. al.
Insights into the Complex Formed by Matrix Metalloproteinase-2 and Alloxan Inhibitors: Molecular Dynamics Simulations and Free Energy Calculations
score: 0.074492916, PLoS ONE, 2011, Giangreco, Ilenia et. al.
Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition.
score: 0.074240153, Antimicrobial agents and chemotherapy, 1994, Hoshino, K et. al.
On the binding affinity of macromolecular interactions: daring to ask why proteins interact
score: 0.073894317, Journal of the Royal Society Interface, 2013, Kastritis, Panagiotis L.; Bonvin, Alexandre M. J. J.
New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors.
score: 0.07379178, Molecular pharmacology, 2012, Jacobson, Kenneth A; Costanzi, Stefano
Development of highly predictive 3D-QSAR CoMSIA models for anthraquinone and acridone derivatives as telomerase inhibitors targeting G-quadruplex DNA telomere
score: 0.073596096, Journal of Molecular Graphics and Modelling, 2010, Zambre, Vishal P. et. al.
Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase
score: 0.073429182, Bioorganic & Medicinal Chemistry, 1993, Costantino, Gabriele et. al.
Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus.
score: 0.073290212, Antimicrobial agents and chemotherapy, 1993, Frick, L W et. al.
Inhibition of episomal hepatitis B virus DNA in vitro by 2,4-diamino-7- (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-pyrrolo[2,3-d]pyrimidine.
score: 0.073095999, Antimicrobial agents and chemotherapy, 1995, Ojwang, J O et. al.
Protein Simulation and Drug Design
score: 0.072976388, Advances in Protein Chemistry, 2003, Wong, Chung F.; McCammon, J.Andrew
Modeling of Human Prokineticin Receptors: Interactions with Novel Small-Molecule Binders and Potential Off-Target Drugs
score: 0.072521831, PLoS ONE, 2011, Levit, Anat et. al.
Theoretical studies of QSAR and molecular design on a novel series of ethynyl-3-quinolinecarbonitriles as SRC inhibitors.
score: 0.072451837, Chemical biology & drug design, 2012, Fang, Dan Qing et. al.
Primary and secondary metabolism of pentamidine by rats.
score: 0.072374379, Antimicrobial agents and chemotherapy, 1992, Berger, B J et. al.
Discovery and evaluation of inhibitors of human sphingosine kinase.
score: 0.07232749, Cancer research, 2003, French, Kevin J et. al.
Triazolines—XXVII. Δ 2-1,2,3-triazoline anticonvulsants: Novel ‘built-in’ heterocyclic prodrugs with a unique ‘dual-action’ mechanism for impairing excitatory amino acid l-glutamate neurotransmission
score: 0.071287103, Bioorganic & Medicinal Chemistry, 1996, Kadaba, Pankaja K. et. al.
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
score: 0.070896824, Molecular cancer therapeutics, 2007, Sharp, Swee Y et. al.
Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening
score: 0.070265828, Biochimie, 2012, Zhong, Hai-Jing et. al.
Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening
score: 0.070265828, Biochimie, 2012, Zhong, Hai-Jing et. al.
The pharmacological landscape and therapeutic potential of serine hydrolases.
score: 0.070242371, Nature reviews. Drug discovery, 2012, Bachovchin, Daniel A; Cravatt, Benjamin F
Identification of Novel Functional Inhibitors of Acid Sphingomyelinase
score: 0.06966298, PLoS ONE, 2011, Kornhuber, Johannes et. al.
Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents
score: 0.069258052, PLoS ONE, 2010, Peltonen, Karita et. al.
From magic bullets to designed multiple ligands
score: 0.069237331, Drug Discovery Today, 2004, Morphy, Richard; Kay, Corinne; Rankovic, Zoran
In vitro antistaphylococcal activity and testing of RP 59500, a new streptogramin, by two methods.
score: 0.06838817, Antimicrobial agents and chemotherapy, 1992, Aldridge, K E; Schiro, D D; Varner, L M
Kinetic interactions of tazobactam with beta-lactamases from all major structural classes.
score: 0.068341698, Antimicrobial agents and chemotherapy, 1993, Bush, K; Macalintal, C; Rasmussen, B A; Lee, V J; Yang, Y
Selective inhibition of metabolic enzymes by enzymatically synthesized D-glucal-6-phosphate
score: 0.068227086, Bioorganic & Medicinal Chemistry, 1994, Chenault, H.Keith; Mandes, Robert F.
Target Validation: Linking Target and Chemical Properties to Desired Product Profile
score: 0.068129253, Current Topics in Medicinal Chemistry, 2011, Wyatt, Paul G et. al.
Mechanistic studies on the inhibition of stromelysin by a peptide phosphonamidate
score: 0.067938339, Bioorganic & Medicinal Chemistry, 1993, Izquierdo-Martin, Maria; Ross L., Stein
Resolution of racemic sterically hindered secondary alcohols via enzymatic alcoholysis of their esters. The first enzymatic preparation of optically pure 2,2,2-trifluoro-1-(9-anthryl)ethanols
score: 0.067863143, Bioorganic & Medicinal Chemistry, 1994, Shkolnik, Eleonora; Gutman, Arie L.
Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles.
score: 0.067734103, Antimicrobial agents and chemotherapy, 1997, Hantz, O et. al.
Apoptosis is Induced in Cancer Cells via the Mitochondrial Pathway by the Novel Xylocydine-Derived Compound JRS-15
score: 0.067534805, International Journal of Molecular Sciences, 2013, Sun, Chao et. al.
In vitro activity of HSR-903, a new quinolone.
score: 0.067231058, Antimicrobial agents and chemotherapy, 1997, Takahashi, Y; Masuda, N; Otsuki, M; Miki, M; Nishino, T
Optimisation of the Anti- Trypanosoma brucei Activity of the Opioid Agonist U50488
score: 0.06702411, Chemmedchem, 2011, Smith, Victoria C et. al.
Knowledge-Based, CentralNervous System (CNS) LeadSelection and Lead Optimization for CNS Drug Discovery
score: 0.066838445, ACS Chemical Neuroscience, 2011, Ghose, Arup K. et. al.
Mapping the structural domains of E. coli carbamoyl phosphate synthetase using limited proteolysis
score: 0.066587945, Bioorganic & Medicinal Chemistry, 1995, Mareya, Shadreck M.; Raushel, Frank M.
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML.
score: 0.066404572, British journal of cancer, 2012, Lin, W-H et. al.
EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities
score: 0.06605434, Nucleic Acids Research, 2010, Hsin, Kun-Yi et. al.
Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.
score: 0.065860887, Antimicrobial agents and chemotherapy, 1996, Hawley, S R et. al.
Prediction of oral absorption in humans by experimental immobilized artificial membrane chromatography indices and physicochemical descriptors
score: 0.06578175, International Journal of Pharmaceutics, 2008, Kotecha, Jignesh et. al.
3D-QSAR and preliminary evaluation of anti-inflammatory activity of series of N-pyrrolylcarboxylic acids
score: 0.065386206, Il Farmaco, 2005, Lessigiarska, Iglika et. al.
Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors
score: 0.064774442, BMC Pharmacology, 2011, Durrant, Jacob D; McCammon, J Andrew
The Biology and Chemistry of Antifungal Agents: A Review
score: 0.06439953, Bioorganic & Medicinal Chemistry, 2012, Kathiravan, Muthu K et. al.
O-Acetyltransferases for chloramphenicol and other natural products.
score: 0.064370618, Antimicrobial agents and chemotherapy, 1997, Murray, I A; Shaw, W V
Support studies for installing the phosphodiester residues of the Thy-1 glycoprotein membrane anchor
score: 0.063906288, Bioorganic & Medicinal Chemistry, 1994, Campbell, A.Stewart; Fraser-Reid, Bert
The use of a pharmacophore model for identification of novel ligands for the benzodiazepine binding site of the GABA A receptor
score: 0.063905075, Journal of Molecular Graphics and Modelling, 2004, Kahnberg, Pia et. al.
Stereoselective synthesis of β- arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis
score: 0.063597899, Carbohydrate Research, 2009, Ayers, Benjamin et. al.
Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication.
score: 0.063575012, Antimicrobial agents and chemotherapy, 1993, Kleim, J P et. al.
Synthesis and in vitro examination of [ 124I]-, [ 125I]- and [ 131I]-2-(4-iodophenylamino) pyrido[2,3- d]pyrimidin-7-one radiolabeled Abl kinase inhibitors
score: 0.063365, Nuclear Medicine and Biology, 2005, Veach, Darren R. et. al.
Direct Measurement of the Ionization State of an Essential Guanine in the Hairpin Ribozyme
score: 0.062946394, Nature chemical biology, 2009, Liu, Lu et. al.
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group.
score: 0.062647818, Antimicrobial agents and chemotherapy, 1992, Robinson, M J et. al.
Receptor Guided 3D-QSAR: A Useful Approach for Designing of IGF-1R Inhibitors
score: 0.062249862, Journal of Biomedicine and Biotechnology, 2008, Muddassar, M. et. al.
Activity of clinafloxacin against multidrug-resistant Enterococcus faecium.
score: 0.062231016, Antimicrobial agents and chemotherapy, 1994, Burney, S; Landman, D; Quale, J M
Impact of the CXCR4 structure on docking-based virtual screening of HIV entry inhibitors
score: 0.062155606, Journal of Molecular Graphics and Modelling, 2012, Planesas, Jesús M. et. al.
Impact of the CXCR4 structure on docking-based virtual screening of HIV entry inhibitors
score: 0.062155606, Journal of Molecular Graphics and Modelling, 2012, Planesas, Jesús M. et. al.
Impact of the CXCR4 structure on docking-based virtual screening of HIV entry inhibitors
score: 0.062155606, Journal of Molecular Graphics and Modelling, 2012, Planesas, Jesús M. et. al.
Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A.
score: 0.061077161, Pharmacological reviews, 2011, Cunningham, Christopher W et. al.
In vitro activities of irloxacin and E-3846, two new quinolones.
score: 0.060402019, Antimicrobial agents and chemotherapy, 1990, García-Rodríguez, J A et. al.
Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
score: 0.059904876, Current Opinion in Chemical Biology, 2008, Rishton, Gilbert M
Reevaluation of the factors involved in the efficacy of new beta-lactams against Enterobacter cloacae.
score: 0.059804055, Antimicrobial agents and chemotherapy, 1991, Bellido, F; Pechère, J C; Hancock, R E
Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents
score: 0.059773618, European Journal of Medicinal Chemistry, 2001, Jin, Guang-Zhu et. al.
In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks.
score: 0.059763777, Antimicrobial agents and chemotherapy, 1997, Cullen, J M et. al.
Trovafloxacin, a new fluoroquinolone with potent activity against Streptococcus pneumoniae.
score: 0.058541142, Antimicrobial agents and chemotherapy, 1997, Thomson, K S; Chartrand, S A; Sanders, C C; Block, S L
The nucleoside analog-resistant E89G mutant of human immunodeficiency virus type 1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitors.
score: 0.058472248, Antimicrobial agents and chemotherapy, 1996, Kew, Y; Salomon, H; Olsen, L R; Wainberg, M A; Prasad, V R
Plane of Best Fit: A NovelMethod to Characterize the Three-Dimensionality of Molecules
score: 0.058386258, Journal of Chemical Information and Modeling, 2012, Firth, Nicholas C.; Brown, Nathan; Blagg, Julian
Synthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar sensing.
score: 0.058366696, Chemical biology & drug design, 2007, Akay, Senol et. al.
SIB-DOTA: A trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies
score: 0.058365999, Bioorganic & Medicinal Chemistry, 2012, Vaidyanathan, G. et. al.
Design and Synthesis of Receptor Ligands
score: 0.058090822, Methods in Enzymology, 2003, Yoshihara, Hikari A.I.; Nguyen, Ngoc-Ha; Scanlan, Thomas S.
Pharmacophore generation and atom-based 3D-QSAR of N -iso-propyl pyrrole-based derivatives as HMG-CoA reductase inhibitors
score: 0.057986578, Organic and Medicinal Chemistry Letters, 2012, Teli, Mahesh Kumar; K, Rajanikant G
Enzymatic resolution of racemic 1,2:5,6-di- O-cyclohexylidene and 1,2:3,4-di- O-cyclohexylidene- myo-inositol
score: 0.057721792, Bioorganic & Medicinal Chemistry, 1993, Ling, Lei et. al.
Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro.
score: 0.057529866, Antimicrobial agents and chemotherapy, 1997, Patick, A K; Boritzki, T J; Bloom, L A
Structure-guided expansion of kinase fragment libraries driven by support vector machine models
score: 0.057207218, BBA - Proteins and Proteomics, 2010, Erickson, Jon A. et. al.
Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties
score: 0.056972911, Naunyn-Schmiedeberg's Archives of Pharmacology, 2010, Sapa, Jacek; Nowaczyk, Alicja; Kulig, Katarzyna
Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244.
score: 0.056863949, Antimicrobial agents and chemotherapy, 1997, Bret, L et. al.
Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro.
score: 0.056411814, Antimicrobial agents and chemotherapy, 1992, Werbovetz, K A; Lehnert, E K; Macdonald, T L; Pearson, R D
Inactivation of d-3-hydroxybutyrate dehydrogenase by fumaroyl bis(methyl phosphate)
score: 0.055898727, Bioorganic & Medicinal Chemistry, 1994, Kluger, Ronald; Bearne, Stephen L.
Computational screening and design of S100B ligand to block S100B–p53 interaction
score: 0.055337441, Journal of Molecular Graphics and Modelling, 2009, Whitlow, John L. et. al.
Structural genomics approach to drug discovery for Mycobacterium tuberculosis
score: 0.055186861, Current Opinion in Microbiology, 2009, Ioerger, Thomas R; Sacchettini, James C
Biosynthesis of peptidoglycan in Gaffkya homari: on the target(s) of benzylpenicillin.
score: 0.05513166, Antimicrobial agents and chemotherapy, 1991, Sinha, R K; Neuhaus, F C
In Silico Identification of Structure Requirement for Novel Thiazole and Oxazole Derivatives as Potent Fructose 1,6-Bisphosphatase Inhibitors
score: 0.054447927, International Journal of Molecular Sciences, 2011, Hao, Ming et. al.
Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin
score: 0.05401872, Chemistry & Biology, 2008, Andersen, Ole A. et. al.
Charge separation in a covalently-linked phthalocyanine-oligo(p-phenylenevinylene)-C60 system. Influence of the solvent polarity
score: 0.054007402, Journal of Inorganic Biochemistry, 2012, Cid, Juan-José et. al.
Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design
score: 0.053996896, PLoS ONE, 2009, Pang, Yuan-Ping et. al.
Differential release of smooth-type lipopolysaccharide from Pseudomonas aeruginosa treated with carbapenem antibiotics and its relation to production of tumor necrosis factor alpha and nitric oxide.
score: 0.053990335, Antimicrobial agents and chemotherapy, 1996, Yokochi, T et. al.
Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.
score: 0.053284378, ChemMedChem, 2010, Pisani, Leonardo et. al.
Firefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a Reporter
score: 0.053253125, Chemistry & Biology, 2012, Thorne, Natasha et. al.
The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase.
score: 0.052905962, Nature chemical biology, 2010, Sharma, Sandeep K et. al.
NMR spectroscopy brings invisible protein states into focus.
score: 0.05271329, Nature chemical biology, 2009, Baldwin, Andrew J; Kay, Lewis E
Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.
score: 0.05268932, Antimicrobial agents and chemotherapy, 1990, Schinazi, R F et. al.
Chemical library screen for novel inhibitors of Kaposi's sarcoma-associated herpesvirus processive DNA synthesis
score: 0.052636142, Antiviral Research, 2006, Dorjsuren, Dorjbal et. al.
Aldo–Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers
score: 0.052620196, Frontiers in Pharmacology, 2011, Matsunaga, Toshiyuki et. al.
Novel 2′-hydroxylfurylchalcones: synthesis and biological activity
score: 0.052567794, Carbohydrate Research, 2010, Deng, Yunfei; He, Yuan; Zhan, Taisong; Huang, Qingchun
The 3D-QSAR study of 110 diverse, dual binding, acetylcholinesterase inhibitors based on alignment independent descriptors (GRIND-2). The effects of conformation on predictive power and interpretability of the models
score: 0.052309498, Journal of Molecular Graphics and Modelling, 2012, Vitorović-Todorović, Maja D. et. al.
The 3D-QSAR study of 110 diverse, dual binding, acetylcholinesterase inhibitors based on alignment independent descriptors (GRIND-2). The effects of conformation on predictive power and interpretability of the models
score: 0.052309498, Journal of Molecular Graphics and Modelling, 2012, Vitorović-Todorović, Maja D. et. al.
The 3D-QSAR study of 110 diverse, dual binding, acetylcholinesterase inhibitors based on alignment independent descriptors (GRIND-2). The effects of conformation on predictive power and interpretability of the models
score: 0.052309498, Journal of Molecular Graphics and Modelling, 2012, Vitorović-Todorović, Maja D. et. al.
Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
score: 0.052306253, Antimicrobial agents and chemotherapy, 1993, Urbina, J A et. al.
Pharmacophore-based molecular docking to account for ligand flexibility.
score: 0.052302094, Proteins, 2003, Joseph-McCarthy, Diane et. al.
Comparative in vitro activities of LY191145, a new glycopeptide, and vancomycin against Staphylococcus aureus and Staphylococcus-infected fibrin clots.
score: 0.051949687, Antimicrobial agents and chemotherapy, 1995, Kang, S L; Rybak, M J
Antimicrobial activities of clofazimine and B669 are mediated by lysophospholipids.
score: 0.051484417, Antimicrobial agents and chemotherapy, 1992, Van Rensburg, C E; Jooné, G K; O'Sullivan, J F; Anderson, R
Characterization of lipophilicity and antiproliferative activity of E-2-arylmethylene-1-tetralones and their heteroanalogues
score: 0.051119689, Journal of Chromatography B, 2005, Hallgas, B. et. al.
Dopamine D3 receptor ligands—Recent advances in the control of subtype selectivity and intrinsic activity
score: 0.050928106, BBA - Biomembranes, 2007, Boeckler, Frank; Gmeiner, Peter
Differential in vitro activities of ionophore compounds against Plasmodium falciparum and mammalian cells.
score: 0.050821963, Antimicrobial agents and chemotherapy, 1996, Gumila, C et. al.
Systems-Based Design of Bi-Ligand Inhibitors of Oxidoreductases
score: 0.050750034, Chemistry & Biology, 2004, Sem, Daniel S et. al.
Effects of cinnamic acid derivatives on in vitro growth of Plasmodium falciparum and on the permeability of the membrane of malaria-infected erythrocytes.
score: 0.05065429, Antimicrobial agents and chemotherapy, 1992, Kanaani, J; Ginsburg, H
Enzymic acylation of methyl D- and L-glycopyranosides: Influence of the 3-hydroxyl group
score: 0.050376045, Bioorganic & Medicinal Chemistry, 1993, Colombo, Diego et. al.
Glyoxylic acid production using immobilized glycolate oxidase and catalase
score: 0.050003467, Bioorganic & Medicinal Chemistry, 1994, Seip, John E. et. al.
Comparative in vitro activity of DU-6859a, a new fluoroquinolone agent, against gram-positive cocci.
score: 0.049870786, Antimicrobial agents and chemotherapy, 1994, Korten, V; Tomayko, J F; Murray, B E
Synthesis and biological evaluation of first N-alkyl syn dimeric 4-aryl-1,4-dihydropyridines as competitive HIV-1 protease inhibitors
score: 0.049678879, European Journal of Medicinal Chemistry, 2001, Hilgeroth, Andreas; Billich, Andreas; Lilie, Hauke
Naphthoquinone spiroketal with allelochemical activity from the newly discovered endophytic fungus Edenia gomezpompae
score: 0.049613879, Phytochemistry, 2008, Macías-Rubalcava, Martha L. et. al.
Bioactive conformational generation of small molecules: A comparative analysis between force-field and multiple empirical criteria based methods
score: 0.049477637, BMC Bioinformatics, 2010, Bai, Fang et. al.
Isolation and identification of bioactive compounds in Andrographis paniculata ( Chuanxinlian )
score: 0.049323473, Chinese Medicine, 2010, Chao, Wen-Wan; Lin, Bi-Fong
Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria
score: 0.049289837, Carbohydrate Research, 2007, Davis, Chris B. et. al.
Activity of carbapenem BMS-181139 against Pseudomonas aeruginosa is not dependent on porin protein D2.
score: 0.049060741, Antimicrobial agents and chemotherapy, 1995, Fung-Tomc, J C et. al.
Biochemical Characterization of Cardiolipin Synthase Mutations Associated with Daptomycin Resistance in Enterococci.
score: 0.048883588, Antimicrobial agents and chemotherapy, 2012, Davlieva, Milya et. al.
Mechanism of action of anticandidal dipeptides containing inhibitors of glucosamine-6-phosphate synthase.
score: 0.048841456, Antimicrobial agents and chemotherapy, 1991, Milewski, S et. al.
In vitro activity of DU-6859a against anaerobic bacteria.
score: 0.048215201, Antimicrobial agents and chemotherapy, 1994, Wexler, H M; Molitoris, E; Reeves, D; Finegold, S M
Characterization of a novel extended-spectrum beta-lactamase from Pseudomonas aeruginosa.
score: 0.047730505, Antimicrobial agents and chemotherapy, 1993, Nordmann, P et. al.
Discovery and binding studies on a series of novel Pin1 ligands.
score: 0.047257325, Chemical biology & drug design, 2009, Wu, Bainan et. al.
Do carbohydrates play a role in the lignin peroxidase cycle? Redox catalysis in the endergonic region of the driving force
score: 0.046437115, Bioorganic & Medicinal Chemistry, 1994, Schoemaker, Hans E. et. al.
In vitro investigation of BK-218, a new oral and parenteral cephalosporin.
score: 0.046145899, Antimicrobial agents and chemotherapy, 1990, Szabó, I et. al.
Integrating cheminformatic analysis in combinatorial chemistry
score: 0.046082848, Current Opinion in Chemical Biology, 2004, Blake, James F
Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis
score: 0.045694159, Journal of Molecular Graphics and Modelling, 2012, Li, Yan et. al.
Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis
score: 0.045694159, Journal of Molecular Graphics and Modelling, 2012, Li, Yan et. al.
Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis
score: 0.045694159, Journal of Molecular Graphics and Modelling, 2012, Li, Yan et. al.
Prediction of PKCθ Inhibitory Activity Using the Random Forest Algorithm
score: 0.045691212, International Journal of Molecular Sciences, 2010, Hao, Ming; Li, Yan; Wang, Yonghua; Zhang, Shuwei
The mechanism of Escherichia coli tryptophan indole-lyase: substituent effects on steady-state and pre-steady-state kinetic parameters for aryl-substituted tryptophan derivatives
score: 0.045189415, Bioorganic & Medicinal Chemistry, 1995, Lee, Minsu; Phillips, Robert S.
Strategies for developing protein tyrosine phosphatase inhibitors
score: 0.045156952, Methods, 2007, Tautz, Lutz; Mustelin, Tomas
Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
score: 0.044561985, Antimicrobial agents and chemotherapy, 1995, Reyna, F; Huesca, M; González, V; Fuchs, L Y
Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae
score: 0.04395556, BMC Chemical Biology, 2008, Norambuena, Lorena et. al.
Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines
score: 0.043578736, Biochemical and Biophysical Research Communications, 2012, Hundsdörfer, Claas et. al.
Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule
score: 0.04316572, BMC Pharmacology, 2010, Mishra, Nitish K; Agarwal, Sandhya; Raghava, Gajendra PS
In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms.
score: 0.042411733, Antimicrobial agents and chemotherapy, 1995, Lauterwein, M; Oethinger, M; Belsner, K; Peters, T; Marre, R
The design of novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors
score: 0.042373682, Molecular and Cellular Endocrinology, 2009, Vicker, Nigel et. al.
Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens.
score: 0.042372834, Antimicrobial agents and chemotherapy, 1997, Jacoby, G; Han, P; Tran, J
Comparative activity of cefepime, alone and in combination, against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from cystic fibrosis patients.
score: 0.04235065, Antimicrobial agents and chemotherapy, 1991, Bosso, J A; Saxon, B A; Matsen, J M
Synthesis and properties of a photoaffinity labeling reagent for protoporphyrinogen oxidases, the target enzymes of diphenyl ether herbicides
score: 0.042168037, Bioorganic & Medicinal Chemistry, 1994, O'Connor, Norval et. al.
Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors
score: 0.042161926, Letters in Drug Design & Discovery, 2011, Wang, Yubin et. al.
The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates.
score: 0.042143903, Nature reviews. Drug discovery, 2007, Kramer, Jeffrey A; Sagartz, John E; Morris, Dale L
Structure-based discovery of a new class of Bcl-x L antagonists
score: 0.041009985, Bioorganic Chemistry, 2007, Rega, Michele F. et. al.
Once-daily aminoglycoside dosing assessed by MIC reversion time with Pseudomonas aeruginosa.
score: 0.040987039, Antimicrobial agents and chemotherapy, 1994, Karlowsky, J A; Zhanel, G G; Davidson, R J; Hoban, D J
E-4695, a new C-7 azetidinyl fluoronaphthyridine with enhanced activity against gram-positive and anaerobic pathogens.
score: 0.040942237, Antimicrobial agents and chemotherapy, 1995, Guinea, J et. al.
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.
score: 0.040930965, Proceedings of the National Academy of Sciences of the United States of America, 2009, Miller, Meredith W et. al.
Antipneumococcal activity of grepafloxacin compared to that of other agents by time-kill methodology.
score: 0.040853355, Antimicrobial agents and chemotherapy, 1998, Pankuch, G A; Jacobs, M R; Appelbaum, P C
Synthesis and pharmacological characterization of [ 125I]MRS5127, a high affinity, selective agonist radioligand for the A 3 adenosine receptor
score: 0.040683867, Biochemical Pharmacology, 2010, Auchampach, John A. et. al.
Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database
score: 0.040549344, International Journal of Molecular Sciences, 2012, Fan, Cong et. al.
In vitro and in vivo activities of a new quinolone, WIN 57273, possessing potent activity against gram-positive bacteria.
score: 0.040331553, Antimicrobial agents and chemotherapy, 1990, Sedlock, D M et. al.
Structure–activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A 2 inhibition: syntheses and structure–activity relationships in 1-arylsulfamido-2-alkylpiperazines
score: 0.040300406, European Journal of Medicinal Chemistry, 2001, Binisti, Carine et. al.
Characterization of four beta-lactamases produced by Staphylococcus aureus.
score: 0.040248069, Antimicrobial agents and chemotherapy, 1992, Zygmunt, D J; Stratton, C W; Kernodle, D S
A practical view of ‘druggability’
score: 0.04016168, Current Opinion in Chemical Biology, 2006, Keller, Thomas H; Pichota, Arkadius; Yin, Zheng
1α,25(OH) 2 -3-Epi-Vitamin D 3 , a Natural Physiological Metabolite of Vitamin D 3 : Its Synthesis, Biological Activity and Crystal Structure with Its Receptor
score: 0.039858166, PLoS ONE, 2011, Molnár, Ferdinand et. al.
3-Aminopiperidine-BasedPeptide Analogues as the FirstSelective Noncovalent Inhibitors of the Bacterial Cysteine ProteaseIdeS
score: 0.0398276, Journal of Medicinal Chemistry, 2012, Berggren, Kristina et. al.
Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF
score: 0.039539454, Bioorganic Chemistry, 2009, Sova, Matej et. al.
From mannose to morphan analogues: methyl α-d-mannoside as chiral building block for the synthesis of mono- and bicyclic σ receptor ligands
score: 0.039382839, Carbohydrate Research, 2012, Wiedemeyer, Kathrin; Wünsch, Bernhard
From mannose to morphan analogues: methyl α-d-mannoside as chiral building block for the synthesis of mono- and bicyclic σ receptor ligands
score: 0.039382839, Carbohydrate Research, 2012, Wiedemeyer, Kathrin; Wünsch, Bernhard
Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity
score: 0.03913616, European Journal of Medicinal Chemistry, 2002, Malawska, Barbara et. al.
Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293.
score: 0.039046923, Antimicrobial agents and chemotherapy, 1997, Charpentier, E; Courvalin, P
Inhibition by quinolones of DNA gyrase from Staphylococcus aureus.
score: 0.038904936, Antimicrobial agents and chemotherapy, 1991, Tanaka, M et. al.
Synthesis of 2-isoxazoline and α-hydroxy ketomethylene dipeptide isosteres
score: 0.038460962, Bioorganic & Medicinal Chemistry, 1996, Chung, Yong Jun et. al.
Further characterization of borderline methicillin-resistant Staphylococcus aureus and analysis of penicillin-binding proteins.
score: 0.038415017, Antimicrobial agents and chemotherapy, 1990, Montanari, M P; Tonin, E; Biavasco, F; Varaldo, P E
Novel silicon-based patchouli odorants of the trialkyl(1-hydroxy-1-methylethyl)silane type: design, synthesis, and olfactory properties.
score: 0.03833087, Chemistry (Weinheim an der Bergstrasse, Germany), 2010, Sunderkötter, Astrid et. al.
2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 1. Structure–activity relationships of the terminal aryl ring
score: 0.038134864, European Journal of Medicinal Chemistry, 2001, Müller, Klaus; Altmann, Reinhold; Prinz, Helge
N,N-dimethylglycyl-amido derivative of minocycline and 6-demethyl-6-desoxytetracycline, two new glycylcyclines highly effective against tetracycline-resistant gram-positive cocci.
score: 0.038059795, Antimicrobial agents and chemotherapy, 1994, Goldstein, F W; Kitzis, M D; Acar, J F
Structural studies of B-type Aurora kinase inhibitors using computational methods.
score: 0.037353356, Acta pharmacologica Sinica, 2010, Neaz, Mm; Muddassar, M; Pasha, Fa; Cho, Seung Joo
Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase
score: 0.03720352, Virology Journal, 2012, Elleder, Daniel et. al.
Synthesis, biological evaluation and molecular modeling studies of N-aryl-2-arylthioacetamides as non-nucleoside HIV-1 reverse transcriptase inhibitors.
score: 0.037115372, Chemical biology & drug design, 2010, Xiaohe, Zhu et. al.
New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations
score: 0.037036727, International Journal of Biochemistry and Cell Biology, 2009, Mai, Antonello et. al.
Synthesis and pharmacology of site specific cocaine abuse treatment agents: a new synthetic methodology for methylphenidate analogs based on the Blaise reaction
score: 0.036964944, European Journal of Medicinal Chemistry, 2001, Deutsch, Howard M et. al.
Modelling in vitro hepatotoxicity using molecular interaction fields and SIMCA
score: 0.036878639, Journal of Molecular Graphics and Modelling, 2004, Clark, Robert D et. al.
Structure-Based Discovery of Potassium Channel Blockers from Natural Products
score: 0.03670568, Chemistry & Biology, 2003, Liu, Hong et. al.
3,8-Diazabicyclo-[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent
score: 0.036317648, European Journal of Medicinal Chemistry, 2001, Villa, Stefania et. al.
Improving the prediction of the brain disposition for orally administered drugs using BDDCS
score: 0.03602066, Advanced Drug Delivery Reviews, 2012, Broccatelli, Fabio et. al.
Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2).
score: 0.03596851, Antimicrobial agents and chemotherapy, 1996, Gazouli, M et. al.
Antimalarial activity of WR 243251, a Dihydroacridinedione.
score: 0.035735038, Antimicrobial agents and chemotherapy, 1994, Berman, J et. al.
Reporter gene technology to assess activity of antimycobacterial agents in macrophages.
score: 0.035720584, Antimicrobial agents and chemotherapy, 1996, Arain, T M; Resconi, A E; Singh, D C; Stover, C K
Identification of a highly potent vitamin D receptor antagonist: (25 S)-26-Adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D 3 (ADMI3)
score: 0.035542132, Archives of Biochemistry and Biophysics, 2007, Igarashi, Miharu et. al.
SARS-CoV protease inhibitors design using virtual screening method from natural products libraries.
score: 0.035527149, Journal of computational chemistry, 2005, Liu, Bing; Zhou, Jiaju
Correlation between ultra-high performance liquid chromatography–tandem mass spectrometry and reversed-phase thin-layer chromatography hydrophobicity data for evaluation of angiotensin-converting enzyme inhibitors absorption
score: 0.035437114, Journal of Chromatography A, 2012, Odovic, Jadranka V. et. al.
Titanocene / cyclodextrin supramolecular systems: a theoretical approach
score: 0.035167498, Chemistry Central Journal, 2012, Riviş, Adrian et. al.
EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities.
score: 0.034460279, Nucleic acids research, 2011, Hsin, Kun-Yi et. al.
Discovery and development of thiazolo[3,2-a]pyrimidinone derivatives as general inhibitors of Bcl-2 family proteins.
score: 0.034453002, ChemMedChem, 2011, Zhou, Bingcheng et. al.
A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential
score: 0.034309995, European Journal of Medicinal Chemistry, 2002, Zhu, Chengyue; Jiang, Lan; Chen, Teng-Man; Hwang, Kin-Kai
Three-dimensional quantitative structure–activity relationships study on HIV-1 reverse transcriptase inhibitors in the class of dipyridodiazepinone derivatives, using comparative molecular field analysis 1 1 Color Plate 1 and color plate 2 for this article are on page 601.
score: 0.033976394, Journal of Molecular Graphics and Modelling, 2000, Pungpo, Pornpan; Hannongbua, Supa
Cyclodextrin-based pharmaceutics: past, present and future.
score: 0.033823953, Nature reviews. Drug discovery, 2004, Davis, Mark E; Brewster, Marcus E
Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis
score: 0.033823697, PLoS Computational Biology, 2009, Kinnings, Sarah L. et. al.
In vitro antimicrobial susceptibilities of Nocardia species.
score: 0.033721667, Antimicrobial agents and chemotherapy, 1993, Khardori, N; Shawar, R; Gupta, R; Rosenbaum, B; Rolston, K
Susceptibilities of ampicillin-resistant strains of Salmonella other than S. typhi to 10 antimicrobial agents.
score: 0.033502384, Antimicrobial agents and chemotherapy, 1992, Alós, J I et. al.
Drug Absorption Modeling as a Tool to Define the Strategy in Clinical Formulation Development
score: 0.032936629, The AAPS Journal, 2008, Kuentz, Martin
Development of improved PPARβ/δ inhibitors.
score: 0.032756122, ChemMedChem, 2012, Toth, Philipp M et. al.
NMR Analysis Demonstrates Immunoglobulin G N -glycans are Accessible and Dynamic
score: 0.032443177, Nature chemical biology, 2011, Barb, Adam W.; Prestegard, James H.
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
score: 0.032157166, The Journal of pharmacology and experimental therapeutics, 2010, Mourey, Robert J et. al.
Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D 3 Catalog Construction
score: 0.032078267, Journal of Combinatorial Chemistry, 2008, Scott, William L. et. al.
Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.
score: 0.031985922, Proceedings of the National Academy of Sciences of the United States of America, 2000, Shakespeare, W et. al.
Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms.
score: 0.031963805, Antimicrobial agents and chemotherapy, 1990, Richman, J; Zolezio, H; Tang-Liu, D
Chemical synthesis and biological properties of pyridine epothilones * * This paper is dedicated to Professor José Barluenga on the occasion of his 60th birthday.
score: 0.031961919, Chemistry & Biology, 2000, Nicolaou, KC et. al.
From mannose to morphan analogues: methyl α-D-mannoside as chiral building block for the synthesis of mono- and bicyclic σ receptor ligands
score: 0.031716702, Carbohydrate Research, 2012, Wiedemeyer, Kathrin; Wünsch, Bernhard
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.
score: 0.031554158, Proceedings of the National Academy of Sciences of the United States of America, 2008, Tsai, James et. al.
Molecular dynamics simulations and in silico peptide ligand screening of the Elk-1 ETS domain
score: 0.031310871, Journal of Cheminformatics, 2011, Hussain, Abrar; Shaw, Peter E; Hirst, Jonathan D
Submicellar complexes may initiate the fungicidal effects of cationic amphiphilic compounds on Candida albicans.
score: 0.030977618, Antimicrobial agents and chemotherapy, 1997, Ahlström, B et. al.
In vitro activity of azithromycin against bacterial enteric pathogens.
score: 0.030856877, Antimicrobial agents and chemotherapy, 1993, Gordillo, M E; Singh, K V; Murray, B E
Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen
score: 0.030638495, Toxicon, 2010, Wahome, Paul G. et. al.
A new strategy for the cloning, overexpression and one step purification of three DHAP-dependent aldolases: Rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase 1
score: 0.030456988, Bioorganic & Medicinal Chemistry, 1995, Garcia-Junceda, Eduardo et. al.
Synthesis and evaluation of potential N π and N σ metal chelation sites within the β-hydroxy- l-histidine subunit of bleomycin A 2: Functional characterization of imidazole N π metal complexation
score: 0.030435533, Bioorganic & Medicinal Chemistry, 1996, Boger, Dale L.; Ramsey, Timothy M.; Cai, Hui
Characterization of mechanisms of resistance to beta-lactam antibiotics in methicillin-resistant strains of Staphylococcus saprophyticus.
score: 0.030394984, Antimicrobial agents and chemotherapy, 1990, Stratton, C W; Gelfand, M S; Gerberding, J L; Chambers, H F
Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors
score: 0.030376177, European Journal of Pharmacology, 2001, Zaveri, Nurulain et. al.
3D-QSAR CoMFA analysis of C 5 substituted pyrrolotriazines as HER2 (ErbB2) inhibitors
score: 0.030275586, Journal of Molecular Graphics and Modelling, 2008, Awale, Mahendra; Mohan, C. Gopi
Antibacterial activity of WY-49605 compared with those of six other oral agents and selection of disk content for disk diffusion susceptibility testing.
score: 0.030221859, Antimicrobial agents and chemotherapy, 1995, Fuchs, P C; Barry, A L; Sewell, D L
Imidazolines as Non-Classical Bioisosteres of N -Acyl Homoserine Lactones and Quorum Sensing Inhibitors
score: 0.029854371, International Journal of Molecular Sciences, 2012, Reyes-Arellano, Alicia et. al.
High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones
score: 0.029659306, Chemistry & Biology, 2007, Tropak, Michael B. et. al.
Binding orientations, QSAR, and molecular design of thiophene derivative inhibitors.
score: 0.029596133, Chemical biology & drug design, 2009, Liao, Si Yan et. al.
High-throughput docking as a source of novel drug leads
score: 0.029512753, Current Opinion in Chemical Biology, 2004, Alvarez, Juan C
Therapeutic approaches to preventing cell death in Huntington disease
score: 0.029466101, Progress in Neurobiology, 2012, Kaplan, Anna; Stockwell, Brent R.
Synthesis and evaluation of deglycobleomycin A 2 analogues containing a tertiary N-methyl amide and simple ester replacement for the l-histidine secondary amide: Direct functional characterization of the requirement for secondary amide metal complexation
score: 0.029400083, Bioorganic & Medicinal Chemistry, 1996, Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Selective recognition of the m 5 CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking
score: 0.029221088, Bioorganic & Medicinal Chemistry, 1995, Johnson, Wendell S.; He, Qiao-Yun; Tomasz, Maria
The Gramine Route to Pyrido[4,3- b ]indol-3-ones – Identification of a New Cytotoxic Lead
score: 0.028794072, Scientia Pharmaceutica, 2010, Wollein, Uwe; Bracher, Franz
A-ring bridged steroids as potent inhibitors of aromatase
score: 0.028152251, Journal of Steroid Biochemistry and Molecular Biology, 1993, Peet, Norton P. et. al.
Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.
score: 0.028100002, Antimicrobial agents and chemotherapy, 1995, Bartlett, M S; Shaw, M; Navaran, P; Smith, J W; Queener, S F
Effects of protease inhibitors on replication of various myxoviruses.
score: 0.02808067, Antimicrobial agents and chemotherapy, 1992, Hosoya, M; Matsuyama, S; Baba, M; Suzuki, H; Shigeta, S
Predictive ADMET studies, the challenges and the opportunities
score: 0.028040387, Current Opinion in Chemical Biology, 2004, Davis, Andrew M; Riley, Robert J
T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1.
score: 0.027901417, Antimicrobial agents and chemotherapy, 1995, Ojwang, J O et. al.
Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation.
score: 0.027847776, Molecular cancer therapeutics, 2012, Katt, William P et. al.
"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence
score: 0.027704059, Retrovirology, 2009, Savarino, Andrea et. al.
Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase.
score: 0.027569435, Antimicrobial agents and chemotherapy, 1993, Rather, P N et. al.
Methods for Predicting Human Drug Metabolism
score: 0.026871762, Advances in Clinical Chemistry, 2007, Jolivette, Larry J.; Ekins, Sean
Methods for Predicting Human Drug Metabolism
score: 0.026871762, Advances in Clinical Chemistry, 2007, Jolivette, Larry J.; Ekins, Sean
Recent Advances in Fragment-Based QSAR and Multi-Dimensional QSAR Methods
score: 0.026845494, International Journal of Molecular Sciences, 2010, Myint, Kyaw Zeyar; Xie, Xiang-Qun
The second Phytophthora mating hormone defines interspecies biosynthetic crosstalk.
score: 0.026748726, Nature chemical biology, 2011, Ojika, Makoto et. al.
Trypanosoma cruzi: Antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro
score: 0.02659131, Experimental Parasitology, 2009, Mezencev, Roman et. al.
Characterization of unusual tetracycline-resistant gram-positive bacteria.
score: 0.026414839, Antimicrobial agents and chemotherapy, 1991, Roberts, M C; Moncla, B J; Hillier, S L
In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor.
score: 0.02612481, Antimicrobial agents and chemotherapy, 1993, Otto, M J et. al.
Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target.
score: 0.025980408, Angewandte Chemie (International ed. in English), 2010, Cummings, Maxwell D et. al.
Crossing borders to bind proteins—a new concept in protein recognition based on the conjugation of small organic molecules or short peptides to polypeptides from a designed set
score: 0.025961624, Analytical and Bioanalytical Chemistry, 2011, Baltzer, Lars
Knowledge-based chemoinformatic approaches to drug discovery
score: 0.025633662, Drug Discovery Today, 2006, Ghose, Arup K. et. al.
Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1
score: 0.025122697, Chemmedchem, 2011, Su, Xiangdong et. al.
In vitro and in vivo activities of DQ-2556 and its mode of action.
score: 0.024870413, Antimicrobial agents and chemotherapy, 1992, Tanaka, M; Otsuki, M; Nishino, T
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi.
score: 0.024777311, ChemMedChem, 2007, Leite, Ana Cristina Lima et. al.
KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
score: 0.024423382, BMC Cancer, 2009, Valensin, Silvia et. al.
Actin-Binding Toxin “Tail” Wags the Dog
score: 0.024340903, Chemistry & Biology, 2008, Tanaka, Junichi; Craig Blain, J.; Allingham, John S.
Whole-Genome Analysis of a Daptomycin-Susceptible Enterococcus faecium and Its Daptomycin-Resistant Variant Arising During Therapy.
score: 0.024238704, Antimicrobial agents and chemotherapy, 2012, Tran, Truc T et. al.
Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating.
score: 0.023921773, Molecular pharmacology, 2005, Pedemonte, Nicoletta et. al.
In vitro activities of 15 oral beta-lactams against Klebsiella pneumoniae harboring new extended-spectrum beta-lactamases.
score: 0.023753422, Antimicrobial agents and chemotherapy, 1990, Kitzis, M D et. al.
TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases.
score: 0.023565364, Antimicrobial agents and chemotherapy, 1996, Bradford, P A; Jacobus, N V; Bhachech, N; Bush, K
Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line
score: 0.023464466, Chemistry & Biology, 2003, Liu, Yichin et. al.
In vitro activity of OPC-17116.
score: 0.023439457, Antimicrobial agents and chemotherapy, 1992, Neu, H C; Fang, W; Gu, J W; Chin, N X
Canadian national survey of prevalence of antimicrobial resistance among clinical isolates of Streptococcus pneumoniae. Canadian Bacterial Surveillance Network.
score: 0.023238079, Antimicrobial agents and chemotherapy, 1996, Simor, A E; Louie, M; Low, D E
Conjugative transfer of high-level mupirocin resistance from Staphylococcus haemolyticus to other staphylococci.
score: 0.023224183, Antimicrobial agents and chemotherapy, 1997, Udo, E E; Jacob, L E; Mokadas, E M
Proteus mirabilis dehydrogenates aldonates and aldarates with an ( R)-configured α-carbon atom to the corresponding 2-oxocarboxylates
score: 0.023169731, Bioorganic & Medicinal Chemistry, 1994, Schinschel, Carsten; Simon, Helmut
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
score: 0.023168216, Antimicrobial agents and chemotherapy, 1994, Guo, L et. al.
Design, synthesis, and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives.
score: 0.022887588, Acta pharmacologica Sinica, 2005, Li, Ming-Hui et. al.
Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria.
score: 0.022731363, Antimicrobial agents and chemotherapy, 1991, Eng, R H; Padberg, F T; Smith, S M; Tan, E N; Cherubin, C E
Random mutagenesis of staphylococcal nuclease and phage display selection
score: 0.022591457, Bioorganic & Medicinal Chemistry, 1995, Light, James; Lerner, Richard A.
Novel method for assessing postantibiotic effect by using the Coulter counter.
score: 0.022453113, Antimicrobial agents and chemotherapy, 1996, Li, R C; Lee, S W; Lam, J S
Fragonomics: fragment-based drug discovery
score: 0.022322285, Current Opinion in Chemical Biology, 2005, Zartler, Edward R; Shapiro, Michael J
A feature based pharmacophore for Candida albicans MyristoylCoA: protein N-myristoyltransferase inhibitors
score: 0.022078163, European Journal of Medicinal Chemistry, 2001, Karki, Rajeshri G; Kulkarni, Vithal M
Predicting plasma protein binding of drugs: a new approach
score: 0.021986854, Biochemical Pharmacology, 2002, Kratochwil, Nicole A et. al.
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi ☆
score: 0.021563878, Molecular and Biochemical Parasitology, 2010, Jones, Deuan C. et. al.
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
score: 0.021563878, Molecular & Biochemical Parasitology, 2010, Jones, Deuan C. et. al.
Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes *
score: 0.021484186, The Journal of Biological Chemistry, 2010, Christian, Frank et. al.
Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors
score: 0.021271894, Il Farmaco, 2005, Cusan, Claudia et. al.
Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin.
score: 0.020958051, Antimicrobial agents and chemotherapy, 1997, Doit, C et. al.
Use of radioactive ethanolamine incorporation into phospholipids to assess in vitro antimalarial activity by the semiautomated microdilution technique.
score: 0.020847713, Antimicrobial agents and chemotherapy, 1992, Elabbadi, N; Ancelin, M L; Vial, H J
Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase.
score: 0.0208225, Antimicrobial agents and chemotherapy, 1990, Loya, S; Tal, R; Kashman, Y; Hizi, A
Lobarin from the Sumatran lichen, Stereocaulon halei
score: 0.020802965, Fitoterapia, 2012, Ismed, Friardi et. al.
Lobarin from the Sumatran lichen, Stereocaulon halei
score: 0.020802965, Fitoterapia, 2012, Ismed, Friardi et. al.
Lobarin from the Sumatran lichen, Stereocaulon halei
score: 0.020802965, Fitoterapia, 2012, Ismed, Friardi et. al.
Overexpression, one-step purification and characterization of UDP-glucose dehydrogenase and UDP- N-acetylglucosamine pyrophosphorylase
score: 0.020684343, Bioorganic & Medicinal Chemistry, 1996, De Luca, Claudio et. al.
Chemoproteomics as a basis for post-genomic drug discovery
score: 0.020518102, Drug Discovery Today, 2002, Beroza, Paul et. al.
Fluconazole tolerance in clinical isolates of Cryptococcus neoformans.
score: 0.020335657, Antimicrobial agents and chemotherapy, 1997, Venkateswarlu, K et. al.
Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection.
score: 0.020209284, Antimicrobial agents and chemotherapy, 1996, Bergeron, J et. al.
Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum.
score: 0.020195546, Antimicrobial agents and chemotherapy, 1992, Karle, J M; Karle, I L; Gerena, L; Milhous, W K
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
score: 0.019971826, Biochemical Journal, 2011, Birkholtz, Lyn-Marie et. al.
New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts
score: 0.019819352, Chemistry Central Journal, 2012, Riadi, Yassine et. al.
Inhibition of lipases by phosphonates
score: 0.019509973, Bioorganic & Medicinal Chemistry, 1994, Björkling, F.; Dahl, A.; Patkar, S.; Zundel, M.
Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer.
score: 0.019500537, The Journal of pharmacology and experimental therapeutics, 2009, Shaw, Arthur Y et. al.
Synthetic studies of roquefortine C: synthesis of isoroquefortine C and a heterocycle.
score: 0.019393592, Proceedings of the National Academy of Sciences of the United States of America, 2004, Richard, David J; Schiavi, Bruno; Joullié, Madeleine M
Synthesis of 1 L- chiro-inositol 2,3,5-trisphosphorothioate, the first partial agonist at the platelet myo-inositol 1,4,5-trisphosphate receptor
score: 0.018665994, Bioorganic & Medicinal Chemistry, 1994, Liu, Changsheng et. al.
Susceptibility of Xanthomonas maltophilia to six quinolones and study of outer membrane proteins in resistant mutants selected in vitro.
score: 0.018073368, Antimicrobial agents and chemotherapy, 1992, Lecso-Bornet, M et. al.
Current topics in computer-aided drug design.
score: 0.017668207, Journal of pharmaceutical sciences, 2008, Taft, Carlton A et. al.
In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi
score: 0.017445569, PLoS Neglected Tropical Diseases, 2010, Chen, Yen Ting et. al.
Design and Synthesis of Receptor Ligands
score: 0.017199845, Methods in Enzymology, 2003, Yoshihara, Hikari A.I.; Nguyen, Ngoc-Ha; Scanlan, Thomas S.
The Transition from a Pharmacophore-Guided Approach to a Receptor-Guided Approach in the Design of Potent Protein Kinase C Ligands
score: 0.017093655, Pharmacology and Therapeutics, 1999, Marquez, Victor E et. al.
Antiretroviral activities of protease inhibitors against murine leukemia virus and simian immunodeficiency virus in tissue culture.
score: 0.017092, Antimicrobial agents and chemotherapy, 1993, Black, P L et. al.
PREDICT modeling and in-silico screening for G-protein coupled receptors.
score: 0.016995354, Proteins, 2004, Shacham, Sharon et. al.
Rifamycins – Obstacles and opportunities
score: 0.016911611, Tuberculosis, 2010, Aristoff, Paul A. et. al.
Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor.
score: 0.016773239, Antimicrobial agents and chemotherapy, 1994, Connell, E V; Hsu, M C; Richman, D D
Human Ether-a-go-go Related Gene (HERG): A Chemist's Perspective
score: 0.016717513, Progress in Medicinal Chemistry, 2005, Vaz, Roy J.; Li, Yi; Rampe, David
Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys.
score: 0.016691588, Antimicrobial agents and chemotherapy, 1994, Cundy, K C; Shaw, J P; Lee, W A
Synthesis, structural characterization and biological study of new organotin(IV), silver(I) and antimony(III) complexes with thioamides
score: 0.016572363, Journal of Inorganic Biochemistry, 2008, Hadjikakou, S.K. et. al.
Comparative in vitro activities of L-695,256, a novel carbapenem, against gram-positive bacteria.
score: 0.016097776, Antimicrobial agents and chemotherapy, 1995, Malanoski, G et. al.
Production of A and C variants of staphylococcal beta-lactamase by methicillin-resistant strains of Staphylococcus aureus.
score: 0.015764674, Antimicrobial agents and chemotherapy, 1994, Norris, S R; Stratton, C W; Kernodle, D S
Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.
score: 0.01559125, Antimicrobial agents and chemotherapy, 1991, Hallett, P; Maxwell, A
Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase
score: 0.015415634, Chemmedchem, 2010, Walton, Jeffrey G A et. al.
1,5-Benzodiazepines XIV. Synthesis of new substituted 9 H-bis-[1,2,4]triazolo[4,3- a:3′,4′- d] [1,5]benzodiazepines and relate compounds endowed with in vitro cytotoxic properties
score: 0.015365051, Il Farmaco, 2005, Di Braccio, Mario et. al.
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase
score: 0.01522188, Bioorganic Chemistry, 2008, Zhang, Jianmin et. al.
Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug.
score: 0.015120746, Molecular cancer therapeutics, 2002, de Groot, Franciscus M H et. al.
Macromolecular mechanisms of sputum inhibition of tobramycin activity.
score: 0.014573406, Antimicrobial agents and chemotherapy, 1995, Hunt, B E; Weber, A; Berger, A; Ramsey, B; Smith, A L
Discovery and Use of Small Molecules for Probing Biological Processes in Zebrafish
score: 0.014421971, Methods in Cell Biology, 2004, Peterson, Randall T.; Fishman, Mark C.
Strategies for targeting protein-protein interactions with synthetic agents.
score: 0.014361321, Angewandte Chemie (International ed. in English), 2005, Yin, Hang; Hamilton, Andrew D
A comparison of proteins and peptides as substrates for microsomal and solubilized oligosaccharyltransferase
score: 0.014286551, Bioorganic & Medicinal Chemistry, 1994, Liu, Yun-Li; Hoops, Geoffrey C.; Coward, James K.
Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors
score: 0.014275878, Retrovirology, 2009, Serrao, Erik et. al.
Rapid emergence of quinolone resistance in cirrhotic patients treated with norfloxacin to prevent spontaneous bacterial peritonitis.
score: 0.013492257, Antimicrobial agents and chemotherapy, 1994, Dupeyron, C et. al.
Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells.
score: 0.013385793, Antimicrobial agents and chemotherapy, 1996, Wachsman, M; Hamzeh, F M; Saito, H; Lietman, P S
Discovery and Use of Small Molecules for Probing Biological Processes in Zebrafish
score: 0.012866119, Methods in Cell Biology, 2004, Peterson, Randall T.; Fishman, Mark C.
Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics
score: 0.01274546, Chemistry & Biology, 2004, Kao, Richard Y. et. al.
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.
score: 0.012617836, Proceedings of the National Academy of Sciences of the United States of America, 2001, Read, M et. al.
Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells.
score: 0.012488407, Antimicrobial agents and chemotherapy, 1996, Korba, B E; Boyd, M R
Cyclization in concert.
score: 0.012460186, Nature chemical biology, 2008, Fraaije, Marco W; Mattevi, Andrea
Carbohydrate-Based Antibiotics: A New Approach to Tackling the Problem of Resistance.
score: 0.012141996, Angewandte Chemie (International ed. in English), 2001, Ritter, Thomas K.; Wong, Chi-Huey
Inhibition of Toxoplasma gondii protein synthesis by azithromycin.
score: 0.012115941, Antimicrobial agents and chemotherapy, 1993, Blais, J; Garneau, V; Chamberland, S
Generation of inhibitor-sensitive protein tyrosine phosphatases via active-site mutations
score: 0.012014484, Methods, 2007, Bishop, Anthony C.; Zhang, Xin-Yu; Lone, Anna Mari
In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth.
score: 0.01179958, Antimicrobial agents and chemotherapy, 1993, Karlowsky, J A et. al.
First round of a focused library of cholera toxin inhibitors
score: 0.011559523, Carbohydrate Research, 2007, Podlipnik, Črtomir et. al.
BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine.
score: 0.011474454, Antimicrobial agents and chemotherapy, 1991, Richman, D et. al.
Effect of diallyl disulfide on insulin-like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis
score: 0.011394747, Phytomedicine, 2012, Arunkumar, R. et. al.
Effect of diallyl disulfide on insulin-like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis
score: 0.011394747, Phytomedicine, 2012, Arunkumar, R. et. al.
A novel mechanism for inhibition of HIV-1 reverse transcriptase
score: 0.010721794, Bioorganic Chemistry, 2002, Skillman, A.Geoffrey et. al.
Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole.
score: 0.010556995, Antimicrobial agents and chemotherapy, 1994, Chan, F T; Guan, M X; Mackenzie, A M; Diaz-Mitoma, F
Subtilisin and α-chymotrypsin catalyzed synthesis of peptides containing arginine and lysine p-nitroanilides as c-terminal moieties
score: 0.010467389, Bioorganic & Medicinal Chemistry, 1995, Stepanov, Valentin M. et. al.
Non-thiol farnesyltransferase inhibitors: utilization of the far aryl binding site by 5-cinnamoylaminobenzophenones.
score: 0.010379974, Archiv der Pharmazie, 2004, Mitsch, Andreas et. al.
Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound
score: 0.010323796, Structure, 2012, Gelin, Muriel et. al.
Identification of Potent EGFR Inhibitors from TCM Database@Taiwan
score: 0.010133294, PLoS Computational Biology, 2011, Yang, Shun-Chieh et. al.
In vitro activity of the trinem sanfetrinem (GV104326) against gram-positive organisms.
score: 0.010064888, Antimicrobial agents and chemotherapy, 1996, Singh, K V; Coque, T M; Murray, B E
Application of a Dried-DMSO rapid throughput 24-h equilibrium solubility in advancing discovery candidates
score: 0.009809222, European Journal of Pharmaceutical Sciences, 2009, Alelyunas, Yun W. et. al.
Interaction Of Pseudolaric Acid B With The Colchicine Site Of Tubulin
score: 0.0096294648, Biochemical Pharmacology, 2012, Sarkar, Taradas et. al.
Bactericidal activity of ramoplanin against antibiotic-resistant enterococci.
score: 0.0095523179, Antimicrobial agents and chemotherapy, 1992, Johnson, C C; Taylor, S; Pitsakis, P; May, P; Levison, M E
Trimethoprim resistance in Escherichia coli isolates from a geriatric unit.
score: 0.0093166364, Antimicrobial agents and chemotherapy, 1990, Heikkilä, E; Sundström, L; Huovinen, P
Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis
score: 0.0093152989, Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology, 2001, Paiva, Anthony M. et. al.
Design of peptide agonists
score: 0.0091020825, Methods in Enzymology, 2002, Hruby, Victor J.; Agnes, Richard S.; Cai, Chaozhong
Design of peptide agonists
score: 0.0091020825, Methods in Enzymology, 2002, Hruby, Victor J.; Agnes, Richard S.; Cai, Chaozhong
Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells
score: 0.0089459681, Biochimie, 2012, Sidibe, Assitan et. al.
Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells
score: 0.0089459681, Biochimie, 2012, Sidibe, Assitan et. al.
Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics.
score: 0.0088571947, Antimicrobial agents and chemotherapy, 1995, Beauregard, D A; Williams, D H; Gwynn, M N; Knowles, D J
A cell-based high-throughput screen validates the plasmodial surface anion channel as an antimalarial target.
score: 0.0088107618, Molecular pharmacology, 2010, Pillai, Ajay D et. al.
Thyroxine-derivatives of lipopeptides: bifunctional dimerization inhibitors of human immunodeficiency virus-1 protease
score: 0.0086714857, Biochemical Pharmacology, 2003, Dumond, Julien et. al.
Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).
score: 0.0086599195, Antimicrobial agents and chemotherapy, 1997, Hajdu, R et. al.
The application of cassette dosing for pharmacokinetic screening in small-molecule cancer drug discovery.
score: 0.0086518817, Molecular cancer therapeutics, 2007, Smith, Nicola F; Raynaud, Florence I; Workman, Paul
Exploring the P2 and P3 ligand binding features for Hepatitis C virus NS3 protease using some 3D QSAR techniques
score: 0.0086185574, Journal of Molecular Graphics and Modelling, 2008, Wei, Hsin-Yuan; Lu, Chien-Sheng; Lin, Thy-Hou
Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli.
score: 0.0085136366, Antimicrobial agents and chemotherapy, 1997, Ehrhardt, A F; Sanders, C C
In vitro activity of BMS-181184 compared with those of fluconazole and amphotericin B against various candida spp.
score: 0.0084842055, Antimicrobial agents and chemotherapy, 1996, Wardle, H M; Law, D; Denning, D W
Synthesis and histamine H 1-receptor antagonist activity of 4-(diphenylmethyl)-1-piperazine derivatives with a terminal heteroaryl or cycloalkyl amide fragment
score: 0.0084204361, European Journal of Medicinal Chemistry, 1996, Orjales, A et. al.
Large scale preparation of chiral building blocks for the P 3 site of renin inhibitors
score: 0.0082938339, Bioorganic & Medicinal Chemistry, 1994, Doswald, Stephan et. al.
Solvent isotope effects and the nature of electrophilic catalysis m the action of the lactate dehydrogenase of bacillus stearothermophilus
score: 0.0081247063, Bioorganic & Medicinal Chemistry, 1994, Xie, Minli et. al.
Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids.
score: 0.0079630169, Molecular pharmacology, 2008, Seiple, Lauren A et. al.
Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus
score: 0.0077584688, Journal of Biomedicine and Biotechnology, 2011, Hashim, Najihah Mohd et. al.
The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics
score: 0.0074019869, European Journal of Medicinal Chemistry, 2000, Barlocco, Daniela et. al.
Recent developments in the field of antitumour anthracyclines
score: 0.0068373253, European Journal of Medicinal Chemistry, 2001, Monneret, Claude
Iron transport-mediated antibacterial activity of and development of resistance to hydroxamate and catechol siderophore-carbacephalosporin conjugates.
score: 0.0067191485, Antimicrobial agents and chemotherapy, 1992, Minnick, A A; McKee, J A; Dolence, E K; Miller, M J
Modes of action and inhibitory activities of new siderophore-beta-lactam conjugates that use specific iron uptake pathways for entry into bacteria.
score: 0.0066781173, Antimicrobial agents and chemotherapy, 1992, Brochu, A et. al.
In vitro antistaphylococcal activities of two investigative fluoroquinolones, CI-960 and WIN 57273, compared with those of ciprofloxacin, mupirocin (pseudomonic acid), and peptide-class antimicrobial agents.
score: 0.0064764312, Antimicrobial agents and chemotherapy, 1992, Aldridge, K E
Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening.
score: 0.0063954735, Nature reviews. Drug discovery, 2008, Tanrikulu, Yusuf; Schneider, Gisbert
Abnormal peptidoglycan produced in a methicillin-resistant strain of Staphylococcus aureus grown in the presence of methicillin: functional role for penicillin-binding protein 2A in cell wall synthesis.
score: 0.0060074782, Antimicrobial agents and chemotherapy, 1993, de Jonge, B L; Tomasz, A
Selecting compounds for focused screening using linear discriminant analysis and artificial neural networks
score: 0.0059868122, Journal of Molecular Graphics and Modelling, 2004, Ford, M.G; Pitt, W.R; Whitley, D.C
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
score: 0.0056398952, Cancer research, 2007, Sharp, Swee Y et. al.
Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species.
score: 0.0053245229, Antimicrobial agents and chemotherapy, 1994, Yazawa, K et. al.
DNA-Binding Interaction Studies of Microwave Assisted Synthesized Sulfonamide Substituted 8-Hydroxyquinoline Derivatives
score: 0.0051570737, Scientia Pharmaceutica, 2011, Dixit, Ritu B. et. al.
A kinetic study and application of a novel carbonyl reductase isolated from rhodococcus erythropolis
score: 0.0051230604, Bioorganic & Medicinal Chemistry, 1994, Zelinski, Thomas; Kula, Maria-Regina
Use of N-acetylglucosamiyltransferases I and II in the synthesis of a dideoxypentasaccharide
score: 0.0050751025, Bioorganic & Medicinal Chemistry, 1994, Alton, Gordon et. al.
Inhibition of Bacterial Virulence: Drug-Like Molecules Targeting the Salmonella enterica PhoP Response Regulator
score: 0.0048177984, Chemical Biology & Drug Design, 2012, Tang, Yat T et. al.
Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2, lipoxygenase, thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway
score: 0.0047725242, Journal of Molecular Graphics and Modelling, 2009, Sekhar, P. Nataraj et. al.
Protein kinase C inhibitors; Structure—activity relationships in K252c-related compounds
score: 0.0046487662, Bioorganic & Medicinal Chemistry, 1993, Fabre, Serge; Prudhomme, Michelle; Rapp, Maryse
Relationships among antibacterial activity, inhibition of DNA gyrase, and intracellular accumulation of 11 fluoroquinolones.
score: 0.0046053894, Antimicrobial agents and chemotherapy, 1992, Bazile, S; Moreau, N; Bouzard, D; Essiz, M
In vitro activities of a streptogramin (RP59500), three macrolides, and an azalide against four respiratory tract pathogens.
score: 0.0045902288, Antimicrobial agents and chemotherapy, 1995, Barry, A L; Fuchs, P C
Lack of effective bactericidal activity of new quinolones against Brucella spp.
score: 0.0041757715, Antimicrobial agents and chemotherapy, 1991, García-Rodriguez, J A; García Sánchez, J E; Trujillano, I
In vitro activity of LY264826, a new glycopeptide antibiotic, against gram-positive bacteria isolated from patients with cancer.
score: 0.0039407415, Antimicrobial agents and chemotherapy, 1990, Rolston, K V; Nguyen, H; Messer, M
Synthesis and Conformational Analysis of Locked Carbocyclic Analogues of 1,3-Diazepinone Riboside, a High-Affinity Cytidine Deaminase Inhibitor
score: 0.0037843963, The Journal of Organic Chemistry, 2009, Ludek, Olaf R. et. al.
ATPase inhibitors of heat-shock protein 90, second season
score: 0.003550639, Drug Discovery Today, 2010, Janin, Yves L.
Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders
score: 0.00343721, European Journal of Pharmacology, 2010, Chen, Xuanmao; Orser, Beverley A.; MacDonald, John F.
In vitro studies of activity of voriconazole (UK-109,496), a new triazole antifungal agent, against emerging and less-common mold pathogens.
score: 0.0032991341, Antimicrobial agents and chemotherapy, 1997, Radford, S A; Johnson, E M; Warnock, D W
Comparative in vitro antibacterial activity of sparfloxacin (AT-4140; RP 64206), a new quinolone.
score: 0.0028660103, Antimicrobial agents and chemotherapy, 1991, Visser, M R et. al.
In vitro activity of LY 264826 compared with that of vancomycin against 100 clinical isolates each of methicillin-resistant Staphylococcus aureus and Clostridium difficile.
score: 0.0028550892, Antimicrobial agents and chemotherapy, 1990, Fasola, E L; Moody, J A; Gerding, D N; Peterson, L R
Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase
score: 0.0025901928, Chemistry & Biology, 2012, Krieger, Inna V. et. al.
Cytostatic vs. Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth.
score: 0.0024706085, Antimicrobial agents and chemotherapy, 2012, Gorka, Alexander P et. al.
Comparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa bofilms displaying rapid-transport characteristics.
score: 0.0022048502, Antimicrobial agents and chemotherapy, 1997, Vrany, J D; Stewart, P S; Suci, P A
In vitro evaluation of GR69153, a novel catechol-substituted cephalosporin.
score: 0.0021613881, Antimicrobial agents and chemotherapy, 1991, Erwin, M E et. al.
In vitro activities of meropenem, PD 127391, PD 131628, ceftazidime, chloramphenicol, co-trimoxazole, and ciprofloxacin against Pseudomonas cepacia.
score: 0.0021469157, Antimicrobial agents and chemotherapy, 1993, Lewin, C; Doherty, C; Govan, J
Decreased activity of erythromycin against Streptococcus pyogenes in Taiwan.
score: 0.0019649779, Antimicrobial agents and chemotherapy, 1995, Hsueh, P R; Chen, H M; Huang, A H; Wu, J J
Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains.
score: 0.0016220366, Antimicrobial agents and chemotherapy, 1995, Pelletier, C; Prognon, P; Bourlioux, P
Comparative antibacterial activity of L-695,256, a carbapenem active against methicillin-resistant staphylococci.
score: 0.0013672896, Antimicrobial agents and chemotherapy, 1995, Rylander, M; Rollof, J; Jacobsson, K; Norrby, S R
Assessment of two penicillins plus beta-lactamase inhibitors versus cefotaxime in treatment of murine Klebsiella pneumoniae infections.
score: 0.001212686, Antimicrobial agents and chemotherapy, 1996, Fournier, J L et. al.
Dynamic Structure-Based Pharmacophore Model Development: A New and Effective Addition in the Histone Deacetylase 8 (HDAC8) Inhibitor Discovery
score: 0.0011130825, International Journal of Molecular Sciences, 2011, Thangapandian, Sundarapandian et. al.
In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors
score: 0.00060342867, Journal of the American Chemical Society, 2010, Kleiner, Ralph E. et. al.
Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90
score: 0.00038642044, Chemistry & Biology, 2010, Fadden, Patrick et. al.
Molecular docking study of A 3 adenosine receptor antagonists and pharmacophore-based drug design
score: 0.00022170524, Neurochemistry International, 2009, Wei, Jing; Li, Hui; Qu, Wanlu; Gao, Qingzhi
In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes.
score: 0.00021898106, Antimicrobial agents and chemotherapy, 1994, Aldridge, K E; Morice, N; Schiro, D D
Detection of gyrA gene mutations associated with ciprofloxacin resistance in methicillin-resistant Staphylococcus aureus: analysis by polymerase chain reaction and automated direct DNA sequencing.
score: 0.00016150663, Antimicrobial agents and chemotherapy, 1992, Goswitz, J J; Willard, K E; Fasching, C E; Peterson, L R
Strategies for generating less toxic P-selectin inhibitors: Pharmacophore modeling, virtual screening and counter pharmacophore screening to remove toxic hits
score: 0.0001546876, Journal of Molecular Graphics and Modelling, 2008, Ananthula, Ravi Shekar et. al.
Inhibitors of the Cellular Trafficking of Ricin
score: 8.9675902e-05, Toxins, 2012, Barbier, Julien et. al.