Documents in category 'Cancer genes and mutations' (cosmic)

Interphase Cytogenetic Analysis of Solid Tumors by Non-Isotopic DNA in situ Hybridization
score: 11.037303, Progress in Histochemistry and Cytochemistry, 1996, Alers, Janneke C.; van Dekken, Herman

DGP Abstracts
score: 10.848082, Pathology - Research and Practice, 2006,

DGP-Abstracts
score: 10.637113, Pathology - Research and Practice, 2007,

Kinase Inhibitors in Leukemia
score: 10.586815, Advances in Pharmacology, 2004, Levis, Mark; Small, Donald

Systemic mastocytosis in adults: 2011 update on diagnosis, risk stratification, and management.
score: 9.9115293, American journal of hematology, 2011, Pardanani, Animesh

The Origin and Evolution of Mutations in Acute Myeloid Leukemia
score: 9.8404055, Cell, 2012, Welch, John S. et. al.

BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features.
score: 9.6807325, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Cross, N C P et. al.

Abstracts of the XXV Congress of the International Academy of Pathology. October 10-15, 2004. Queensland, Australia.
score: 9.6417279, Pathology international, 2004,

Sarcoma
score: 9.5769502, Mayo Clinic Proceedings, 2007, Skubitz, Keith M.; D'Adamo, David R.

Clinical pharmacogenomic testing of KRAS, BRAF and EGFR mutations by high resolution melting analysis and ultra-deep pyrosequencing
score: 9.4423434, BMC Cancer, 2011, Borràs, Emma et. al.

Contribution of molecular genetic data to the classification of sarcomas
score: 9.4104665, Human Pathology, 2000, Ladanyi, Marc; Bridge, Julia A.

Abstracts DGP Wuppertal 2005
score: 9.37511, Pathology - Research and Practice, 2005,

Abstracts of Melanoma 2010 Congress, the 7th International Melanoma Research Congress and the 4th Melanoma & Skin Cancer Centres Meeting. November 4-7, 2010. Sydney, Australia.
score: 9.3410546, Pigment cell & melanoma research, 2010,

Personalized medicine for lung cancer: new challenges for pathology.
score: 9.2612121, Histopathology, 2012, Kerr, Keith M

Cooperating gene mutations in acute myeloid leukemia: a review of the literature.
score: 9.2306012, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Renneville, A et. al.

Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas
score: 9.1635909, Breast Cancer Research, 2007, Chanock, Stephen J et. al.

The Genetic Basis of Myelodysplastic Syndromes
score: 9.1320091, Hematology/Oncology Clinics of North America, 2010, Bejar, Rafael; Ebert, Benjamin L.

Deregulation of Signaling Pathways in Acute Myeloid Leukemia
score: 9.044329, Seminars in Oncology, 2008, Scholl, Claudia; Gilliland, D. Gary; Fröhling, Stefan

Allele-Specific Polymerase Chain Reaction for the Imatinib-Resistant KIT D816V and D816F Mutations in Mastocytosis and Acute Myelogenous Leukemia
score: 9.0330101, The Journal of Molecular Diagnostics, 2006, Corless, Christopher L. et. al.

The p16 INK4a/CDKN2A tumor suppressor and its relatives
score: 8.8684073, BBA - Reviews on Cancer, 1998, Ruas, Margarida; Peters, Gordon

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2 , MPL , TET2 , ASXL1 , CBL , IDH and IKZF1
score: 8.8616339, Leukemia, 2010, Tefferi, A

The role of genetic testing in soft tissue sarcoma.
score: 8.8145638, Histopathology, 2006, Antonescu, C R

Mutant IDH1 is required for IDH1 mutated tumor cell growth
score: 8.8013149, Oncotarget, 2012, Jin, Genglin et. al.

Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review.
score: 8.7025663, British journal of haematology, 2007, Baldus, Claudia D et. al.

The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group
score: 8.6723346, Lung Cancer, 2012, Thunnissen, Erik et. al.

RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias
score: 8.6329538, Experimental Hematology, 2009, Usher, Suzanne G. et. al.

Molecular pathology and its diagnostic use in bone tumors
score: 8.5980412, Cancer Genetics, 2012, Szuhai, Karoly et. al.

Genomic instability, mutations and expression analysis of the tumour suppressor genes p14 ARF, p15 INK4b, p16 INK4a and p53 in actinic keratosis
score: 8.5948784, Cancer Letters, 2008, Kanellou, P. et. al.

Encyclopaedia of tumour-associated familial disorders. Part I: from AIMAH to CHIME syndrome
score: 8.5295732, Hereditary Cancer in Clinical Practice, 2008, Sijmons, Rolf H

Bone Marrow Symposium 21 September 2008
score: 8.4079397, Journal of Hematopathology, 2008,

Myeloid malignancies: mutations, models and management
score: 8.3832668, BMC Cancer, 2012, Murati, Anne et. al.

Tumor suppressor genes in normal and malignant hematopoiesis.
score: 8.305366, Oncogene, 2002, Krug, Utz; Ganser, Arnold; Koeffler, H Phillip

EGFR-mutated oncogene-addicted non-small cell lung cancer: Current trends and future prospects
score: 8.2993087, Cancer Treatment Reviews, 2012, Soria, Jean-Charles et. al.

Oncogenic mutations as predictive factors in colorectal cancer.
score: 8.298922, Oncogene, 2010, Lièvre, A; Blons, H; Laurent-Puig, P

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1.
score: 8.2739324, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Tefferi, A

Immunohistochemistry in the diagnosis of soft tissue tumours.
score: 8.1939423, Histopathology, 2003, Coindre, J M

Cancer driver mutations in protein kinase genes
score: 8.1939011, Cancer Letters, 2009, Torkamani, Ali; Verkhivker, Gennady; Schork, Nicholas J.

Mutations of BRAF and RAS are rare events in germ cell tumours.
score: 8.1761098, International journal of cancer. Journal international du cancer, 2005, Sommerer, Florian et. al.

G → A mutation of ras genes and infrequent p53 gene mutation in rat transplantable thyroid carcinoma lines from tumors induced in vivo by N-bis(2-hydroxypropyl)nitrosamine
score: 8.1101564, Cancer Letters, 1996, Kitahori, Yoshiteru et. al.

Intragenic Mutations in Thyroid Cancer
score: 8.0754926, Endocrinology and Metabolism Clinics of North America, 2008, Sobrinho-Simões, Manuel et. al.

Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders.
score: 8.0466657, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Walz, C; Cross, N C P; Van Etten, R A; Reiter, A

Cutaneous melanoma susceptibility and progression genes
score: 8.0432528, Cancer Letters, 2005, de Snoo, Femke A.; Hayward, Nicholas K.

The molecular pathogenesis of acute myeloid leukemia
score: 7.9663553, Critical Reviews in Oncology and Hematology, 2005, Steffen, Björn et. al.

Molecular mechanisms that produce secondary MDS/AML by RUNX1/AML1 point mutations.
score: 7.9355466, Journal of cellular biochemistry, 2011, Harada, Yuka; Harada, Hironori

Diagnostic gold standard for soft tissue tumours: morphology or molecular genetics?
score: 7.9297671, Histopathology, 2000, Pfeifer, J D; Hill, D A; O'Sullivan, M J; Dehner, L P

Circulating free tumor DNA and colorectal cancer
score: 7.9159673, Gastroenterologie Clinique et Biologique, 2010, Lecomte, T.; Ceze, N.; Dorval, É.; Laurent-Puig, P.

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
score: 7.8589253, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Steelman, L S et. al.

p53 mutations, protein expression and cell proliferation in squamous cell carcinomas of the head and neck.
score: 7.8334506, British Journal of Cancer, 1995, Nylander, K.; Nilsson, P.; Mehle, C.; Roos, G.

Targeted Therapies: The Rare Cancer Paradigm
score: 7.7892139, Molecular Oncology, 2010, Pierotti, Marco A. et. al.

Our changing view of the genomic landscape of cancer.
score: 7.7132513, The Journal of pathology, 2010, Bell, Daphne W

The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer.
score: 7.6863287, Cancer, 2010, El-Serafi, Mostafa M et. al.

Targeted therapies in myeloid leukemia
score: 7.6843663, Seminars in Cancer Biology, 2004, John, Alison M et. al.

Genetics of therapy-related myelodysplasia and acute myeloid leukemia.
score: 7.6823658, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Pedersen-Bjergaard, J et. al.

Genetic Tests To Evaluate Prognosis and Predict Therapeutic Response in Acute Myeloid Leukemia
score: 7.6289, The Journal of Molecular Diagnostics, 2010, Gulley, Margaret L.; Shea, Thomas C.; Fedoriw, Yuri

p53 mutations, protein expression and cell proliferation in squamous cell carcinomas of the head and neck.
score: 7.6152085, British journal of cancer, 1995, Nylander, K; Nilsson, P; Mehle, C; Roos, G

EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene.
score: 7.6049533, Genes, chromosomes & cancer, 2010, Antonescu, Cristina R et. al.

Detection of genetic alterations in hereditary colorectal cancer screening
score: 7.6033781, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2010, Pineda, Marta et. al.

Abstracts of the XVIth Congress of the International Society of Neuropathology. San Francisco, California, USA. September 10-15, 2006.
score: 7.5767454, Brain pathology (Zurich, Switzerland), 2006,

Predictive advantage of a cell type classification for pulmonary adenocarcinoma coupled with data for p53, K-ras and EGFR alterations.
score: 7.5762901, Cancer science, 2010, Okada, Akira et. al.

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.
score: 7.5679384, Genes, chromosomes & cancer, 1996, Pollock, P M; Pearson, J V; Hayward, N K

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine
score: 7.5442108, EMBO Molecular Medicine, 2010, Dias-Santagata, Dora et. al.

Oncogenes and cell proliferation
score: 7.501481, Current Opinion in Genetics & Development, 1997,

Cancer gene discovery in mouse and man
score: 7.460061, Biochimica et Biophysica Acta, 2009, Mattison, Jenny et. al.

Cancer gene discovery in mouse and man
score: 7.460061, BBA - Reviews on Cancer, 2009, Mattison, Jenny et. al.

Molecular pathology of lung cancer: key to personalized medicine.
score: 7.3851414, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Cheng, Liang et. al.

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors.
score: 7.3104434, Nature reviews. Drug discovery, 2009, Jänne, Pasi A; Gray, Nathanael; Settleman, Jeff

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.
score: 7.2837757, EMBO molecular medicine, 2010, Dias-Santagata, Dora et. al.

The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications
score: 7.2679005, Current Genomics, 2007, Arcaro, Alexandre; Guerreiro, Ana S

Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma.
score: 7.2206016, Genes, chromosomes & cancer, 2010, Conway, Caroline et. al.

BRAF mutations in thyroid tumors from an ethnically diverse group
score: 7.1931664, Hereditary Cancer in Clinical Practice, 2012, Schulten, Hans-Juergen et. al.

Molecular targets in acute myelogenous leukemia
score: 7.1869244, Blood Reviews, 2003, Stirewalt, Derek L; Meshinchi, Soheil; Radich, Jerald P

Frequent mutations of Ki- ras codon 12 in N-bis(2-hydroxypropyl)-nitrosamine-initiated thyroid, kidney and lung tumors in Wistar rats
score: 7.1826659, Cancer Letters, 1995, Kitahori, Yoshiteru et. al.

Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR
score: 7.161028, Cancer Treatment Reviews, 2009, Heinemann, Volker et. al.

Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.
score: 7.1438152, Genes, chromosomes & cancer, 2005, Hallor, Karolin Hansén et. al.

KRAS Mutation
score: 7.1419905, The Journal of Molecular Diagnostics, 2010, Franklin, Wilbur A. et. al.

Myeloproliferative neoplasms: From JAK2 mutations discovery to JAK2 inhibitor therapies
score: 7.1036981, Oncotarget, 2011, Passamonti, Francesco et. al.

APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study.
score: 7.0850393, Carcinogenesis, 2004, Lüchtenborg, Margreet et. al.

Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia.
score: 7.0666873, British journal of haematology, 2011, Bacher, Ulrike et. al.

Combinatorial patterns of somatic gene mutations in cancer.
score: 7.0596807, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Yeang, Chen-Hsiang; McCormick, Frank; Levine, Arnold

Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma
score: 7.0569507, The Journal of Molecular Diagnostics, 2007, Spittle, Cynthia et. al.

Atypical Myeloproliferative Disorders: Diagnosis and Management
score: 7.050501, Mayo Clinic Proceedings, 2006, Tefferi, Ayalew; Elliott, Michelle A.; Pardanani, Animesh

K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
score: 7.0303096, Carcinogenesis, 2003, Brink, Mirian et. al.

Wilms Tumor and the WT1 Gene
score: 7.026952, Experimental Cell Research, 2001, Lee, Sean Bong; Haber, Daniel A

MOLECULAR ANALYSIS OF P16 Ink4/CDKN2 AND P15 Ink4B/MTS2 GENES IN PRIMARY HUMAN TESTICULAR GERM CELL TUMORS
score: 7.026443, The Journal of Urology, 1998, HEIDENREICH, AXEL et. al.

Somatic alterations in the human cancer genome
score: 7.0095528, Cancer Cell, 2004, Weir, Barbara; Zhao, Xiaojun; Meyerson, Matthew

Molecular biology of colorectal cancer
score: 6.9680993, Current Problems in Cancer, 1997, Gryfe, Robert et. al.

Detection of SS18-SSX fusion transcripts in formalin-fixed paraffin-embedded neoplasms: analysis of conventional RT-PCR, qRT-PCR and dual color FISH as diagnostic tools for synovial sarcoma.
score: 6.9599496, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2007, Amary, Maria Fernanda C et. al.

Genetic complexity of myeloproliferative neoplasms.
score: 6.9584152, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Kralovics, R

Molecular analysis of the INK4A and INK4B gene loci in human breast cancer cell lines and primary carcinomas
score: 6.9280586, Cancer Genetics and Cytogenetics, 2001, Bisogna, Maria et. al.

Recent advances in the molecular understanding of glioblastoma
score: 6.925012, Journal of Neuro-Oncology, 2012, Bleeker, Fonnet E.; Molenaar, Remco J.; Leenstra, Sieger

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors
score: 6.9227193, Pharmacology and Therapeutics, 2000, Weinstein-Oppenheimer, Caroline R et. al.

The role of Janus kinases in haemopoiesis and haematological malignancy.
score: 6.9195832, British journal of haematology, 2006, Khwaja, Asim

The role of chromosome 21 in hematology and oncology.
score: 6.9103429, Genes, chromosomes & cancer, 2010, Fonatsch, Christa

Identification of genes with abnormal expression changes in acute myeloid leukemia.
score: 6.8831845, Genes, chromosomes & cancer, 2008, Stirewalt, Derek L et. al.

IDH Mutations in Acute Myeloid Leukemia
score: 6.8700564, Human Pathology, 2012, Rakheja, Dinesh et. al.

Current therapeutic strategies for acute myeloid leukaemia.
score: 6.8695276, British journal of haematology, 2006, Kolitz, Jonathan E

BRAF Mutations in Metanephric Adenoma of the Kidney
score: 6.8519111, European Urology, 2012, Choueiri, Toni K. et. al.

Poster Presentations
score: 6.849828, British Journal of Cancer, 1998,

EGFR fluorescence in situ hybridization-positive lung adenocarcinoma: incidence of coexisting KRAS and BRAF mutations
score: 6.8285588, Human Pathology, 2010, Chiosea, Simion et. al.

Targeted therapies in colorectal cancer—an integrative view by PPPM
score: 6.8284354, The EPMA Journal, 2013, Hagan, Suzanne; Orr, Maria C M; Doyle, Brendan

Translocation-Related Sarcomas
score: 6.8242995, Seminars in Oncology, 2009, Mertens, Fredrik et. al.

Pathogenesis, clinical features, and treatment advances in mastocytosis
score: 6.8218987, Best Practice & Research Clinical Haematology, 2006, Pardanani, A.; Akin, C.; Valent, P.

Contents
score: 6.8161888, Current Opinion in Genetics & Development, 1995,

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.
score: 6.8161524, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Falini, B et. al.

KRAS Signaling Pathway Alterations in Microsatellite Unstable Gastrointestinal Cancers
score: 6.8076784, Advances in Cancer Research, 2010, Velho, Sérgia et. al.

Specific-mutational patterns of p53 gene in bladder transitional cell carcinoma among a group of Iraqi patients exposed to war environmental hazards
score: 6.7908245, BMC Research Notes, 2012, Al-Kashwan, Thekra A et. al.

EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics.
score: 6.7777198, Molecular cancer therapeutics, 2013, Arcila, Maria E et. al.

Absence of p16 and p27 gene rearrangements and mutations in de novo myelodysplastic syndromes.
score: 6.7663916, European journal of haematology, 2005, Papageorgiou, Sotirios G et. al.

Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression
score: 6.7643946, Cancer Cell International, 2008, Götz, Rudolf

Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability
score: 6.7586963, Human Pathology, 2009, Kim, Min Sung et. al.

Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.
score: 6.7579675, International journal of cancer. Journal international du cancer, 2011, Shima, Kaori et. al.

Dietary factors and truncating APC mutations in sporadic colorectal adenomas.
score: 6.7467254, International journal of cancer. Journal international du cancer, 2005, Diergaarde, Brenda et. al.

JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science.
score: 6.7260283, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Kilpivaara, O; Levine, R L

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells.
score: 6.6746826, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1998, Drexler, H G

Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma
score: 6.6679075, BMC Cancer, 2013, Santos, Juliana Carvalho et. al.

Anaplastic Lymphoma Kinase: Role in specific tumours, and development of small molecule inhibitors for cancer therapy
score: 6.6521115, Cancer Letters, 2010, Ardini, E. et. al.

Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature.
score: 6.6343354, Human mutation, 2007, Gu, Dongqing et. al.

Abstract
score: 6.6281222, Pathology - Research and Practice, 2000,

Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy
score: 6.627696, Leukemia Research, 2004, Tiesmeier, Jens et. al.

Targeting the p53 Pathway in Ewing Sarcoma
score: 6.6201889, Sarcoma, 2010, Neilsen, Paul M. et. al.

Highly penetrant hereditary cancer syndromes.
score: 6.6146474, Oncogene, 2004, Nagy, Rebecca; Sweet, Kevin; Eng, Charis

Chronotherapy and the molecular clock: Clinical implications in oncology
score: 6.5870718, Advanced Drug Delivery Reviews, 2010, Innominato, Pasquale F. et. al.

Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion–insertion mechanism of EWS–ERG fusion gene formation: a case analysis and literature review
score: 6.5826108, Cancer Genetics and Cytogenetics, 2008, Maire, Georges et. al.

The GIST paradigm: lessons for other kinase-driven cancers.
score: 6.5636717, The Journal of pathology, 2011, Antonescu, Cristina R

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
score: 6.550459, Cell, 2012, Imielinski, Marcin et. al.

Genetics of hepatocellular tumors.
score: 6.548762, Oncogene, 2006, Laurent-Puig, P; Zucman-Rossi, J

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis.
score: 6.5220606, British journal of haematology, 2009, Roy, Anindita; Roberts, Irene; Norton, Alice; Vyas, Paresh

Classification of chronic myeloid disorders: From Dameshek towards a semi-molecular system
score: 6.5066332, Best Practice & Research Clinical Haematology, 2006, Tefferi, Ayalew; Gilliland, Gary

Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors.
score: 6.4873921, Genes, chromosomes & cancer, 2009, Sweeney, Carol et. al.

Colorectal serrated adenocarcinoma shows a different profile of oncogene mutations, MSI status and DNA repair protein expression compared to conventional and sporadic MSI-H carcinomas.
score: 6.4688217, International journal of cancer. Journal international du cancer, 2012, García-Solano, J et. al.

Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
score: 6.449437, Journal of cellular and molecular medicine, 2010, Haan, Claude; Behrmann, Iris; Haan, Serge

Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium.
score: 6.4474778, Cancer research, 1993, Enomoto, T et. al.

BRAF Mutations in Metanephric Adenoma of the Kidney
score: 6.4471701, European Urology, 2012, Choueiri, Toni K. et. al.

Genetic insights into familial cancers – update and recent discoveries
score: 6.4455889, Cancer Letters, 2002, Marsh, Deborah J; Zori, Roberto T

Pathology of soft-tissue tumors: daily diagnosis, molecular cytogenetics and experimental approach.
score: 6.4413153, Pathology international, 2009, Iwasaki, Hiroshi et. al.

Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors.
score: 6.427061, Cancer research, 1994, Weghorst, C M et. al.

Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies
score: 6.4230399, Drug Resistance Updates, 2007, Tortora, Giampaolo et. al.

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
score: 6.4068091, Cancer research, 1994, Greenblatt, M S; Bennett, W P; Hollstein, M; Harris, C C

Statistical method on nonrandom clustering with application to somatic mutations in cancer
score: 6.3767854, BMC Bioinformatics, 2010, Ye, Jingjing et. al.

EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung
score: 6.3562, The Korean Journal of Internal Medicine, 2009, Jang, Tae Won et. al.

The saga of JAK2 mutations and translocations in hematologic disorders: pathogenesis, diagnostic and therapeutic prospects, and revised World Health Organization diagnostic criteria for myeloproliferative neoplasms
score: 6.3517277, Human Pathology, 2008, Smith, Cristina A.; Fan, Guang

Mechanisms of resistance to FLT3 inhibitors
score: 6.3471227, Drug Resistance Updates, 2009, Chu, S. Haihua; Small, Donald

The hypermethylation of the O6-methylguanine-DNA methyltransferase gene promoter in gliomas--correlation with array comparative genome hybridization results and IDH1 mutation.
score: 6.3263814, Genes, chromosomes & cancer, 2012, Tuononen, Katja et. al.

Prognostic impact of chromosomal aberrations in Ewing tumours
score: 6.3254255, British Journal of Cancer, 2002, Hattinger, C M et. al.

P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations.
score: 6.3146819, Journal of cellular physiology, 2008, Mahdavinia, Mahboobeh et. al.

Absence of Ki- ras mutations in exocrine pancreatic tumors from male rats chronically exposed to gabapentin
score: 6.3130579, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1995, Fowler, Michael L. et. al.

An endonuclease/ligase based mutation scanning method especially suited for analysis of neoplastic tissue.
score: 6.3047035, Oncogene, 2002, Huang, Jianmin et. al.

A frequent alteration of p53 gene in carcinoma in adenoma of colon.
score: 6.30131, Cancer research, 1994, Ohue, M et. al.

Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia
score: 6.3008837, Cancer Cell, 2012, Roberts, Kathryn G. et. al.

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.
score: 6.3005855, British journal of pharmacology, 2012, Uitdehaag, Joost C M et. al.

Clinicopathologiclmplications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors
score: 6.2934087, Pathology - Research and Practice, 1998, Yokoyama, Ryohei et. al.

Isolated del(5q) in myeloid malignancies: clinicopathologic and molecular features in 143 consecutive patients.
score: 6.2851326, American journal of hematology, 2011, Patnaik, Mrinal M et. al.

The place of targeted therapies in the management of non-small cell bronchial carcinoma
score: 6.2781472, Revue des Maladies Respiratoires, 2006, Rosell, R. et. al.

New targets and therapeutic approaches for endocrine malignancies
score: 6.2717147, Pharmacology and Therapeutics, 2009, Fassnacht, Martin et. al.

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.
score: 6.270364, Leukemia, 2008, McCubrey, J A et. al.

Genetics of disease
score: 6.2618367, Current Opinion in Genetics & Development, 1996,

Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review
score: 6.2603146, European Journal of Cancer, 2002, Miettinen, Markku; Majidi, Mourad; Lasota, Jerzy

Deletion at chromosome arm 9p in relation to BRAF / NRAS mutations and prognostic significance for primary melanoma
score: 6.2532832, Genes, Chromosomes & Cancer, 2010, Conway, Caroline et. al.

Linking somatic genetic alterations in cancer to therapeutics
score: 6.2247106, Current Opinion in Cell Biology, 2009, Stuart, Darrin; Sellers, William R

Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas.
score: 6.2244695, British journal of cancer, 2001, Parry, L et. al.

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia.
score: 6.2243156, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Balgobind, B V et. al.

IDH mutations in glioma and acute myeloid leukemia
score: 6.2212083, Trends in Molecular Medicine, 2010, Dang, Lenny; Jin, Shengfang; Su, Shinsan M.

JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg?
score: 6.2166451, American journal of hematology, 2012, Scott, Linda M; Rebel, Vivienne I

Preclinical and clinical experience with dasatinib in philadelphia chromosome-negative leukemias and myeloid disorders
score: 6.2005857, Leukemia Research, 2009, Verstovsek, Srdan

JAK2 V617F in Myeloid Disorders: Molecular Diagnostic Techniques and Their Clinical Utility
score: 6.1896552, The Journal of Molecular Diagnostics, 2006, Steensma, David P.

The role of KIT in the management of patients with gastrointestinal stromal tumors
score: 6.1822734, Human Pathology, 2007, Hornick, Jason L.; Fletcher, Christopher D.M.

Detection of Low-Level KRAS Mutations Using PNA-Mediated Asymmetric PCR Clamping and Melting Curve Analysis with Unlabeled Probes
score: 6.1506767, The Journal of Molecular Diagnostics, 2010, Oh, Ji Eun et. al.

Malignant Melanoma–a Genetic Overview
score: 6.145157, Actas dermosifiliograficas, 2009, Bloethner, S. et. al.

Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung
score: 6.1214773, Lung Cancer, 2005, Yoshida, Yukihiro et. al.

Molecular alterations associated with liver metastases development in colorectal cancer patients
score: 6.1206818, British Journal of Cancer, 2011, Bruin, S C et. al.

Expression and genomic profiling of colorectal cancer
score: 6.1184198, BBA - Reviews on Cancer, 2007, Cardoso, J.; Boer, J.; Morreau, H.; Fodde, R.

Identification of Hedgehog pathway responsive glioblastomas by isocitrate dehydrogenase mutation
score: 6.1169862, Cancer Letters, 2013, Gerardo Valadez, J. et. al.

Targeted therapy: for kids, too.
score: 6.1120966, Pediatric blood & cancer, 2005, Corey, Seth J

Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes
score: 6.1089876, Pathologie Biologie, 2007, Paulsson, K.; Johansson, B.

Mutational analysis of K-ras codon 12 in blood samples of patients with acute myeloid leukemia
score: 6.0975234, Leukemia Research, 2010, Preston, Roman et. al.

Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects.
score: 6.0806207, Leukemia, 2003, van der Velden, V H J et. al.

The implication of identifying JAK2 V617F in myeloproliferative neoplasms and myelodysplastic syndromes with bone marrow fibrosis
score: 6.07405, Journal of Hematopathology, 2008, Olsen, Randall J. et. al.

Distinguishing cancer-associated missense mutations from common polymorphisms.
score: 6.0628355, Cancer research, 2007, Kaminker, Joshua S et. al.

Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas.
score: 6.0526276, The Journal of pathology, 2007, Sakamoto, H et. al.

p53 mutation and absence of mdm2 amplification and Ki- ras mutation in 4-hydroxyamino quinoline 1-oxide induced transplantable osteosarcomas in rats
score: 6.0352799, Cancer Letters, 1997, Kido, Akira et. al.

STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma
score: 6.0351698, PLoS ONE, 2012, Looyenga, Brendan D. et. al.

Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models
score: 6.011931, Journal of Translational Medicine, 2012, Wu, Xianhua et. al.

Prognostic impact of chromosomal aberrations in Ewing tumours.
score: 6.0084691, British journal of cancer, 2002, Hattinger, C M et. al.

Chronic myelomonocytic leukemia: 2012 update on diagnosis, risk stratification, and management.
score: 6.0083702, American journal of hematology, 2012, Parikh, Sameer A; Tefferi, Ayalew

Cancer-associated IDH mutations: biomarker and therapeutic opportunities.
score: 6.0019176, Oncogene, 2010, Yen, K E; Bittinger, M A; Su, S M; Fantin, V R

Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.
score: 6.0014799, Cancer research, 1999, Bruening, W et. al.

p53 and Ki- ras as prognostic factors for Dukes' stage B colorectal cancer
score: 5.9992795, European Journal of Cancer, 2000, Bouzourene, H. et. al.

Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2',3'-dideoxycytidine-induced lymphomas.
score: 5.9878622, Cancer research, 1997, Zhuang, S M et. al.

FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes
score: 5.9858196, Experimental Cell Research, 2010, Hafner, Christian et. al.

Prognostic Implications of Gene Mutations in Acute Myeloid Leukemia With Normal Cytogenetics
score: 5.9820862, Seminars in Oncology, 2008, Gaidzik, Verena; Döhner, Konstanze

Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC
score: 5.9809376, British Journal of Cancer, 2008, Kalikaki, A et. al.

APC mutations in synovial sarcoma.
score: 5.965317, The Journal of pathology, 2002, Saito, Tsuyoshi et. al.

Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
score: 5.9621639, Leukemia, 2006, Martelli, A M et. al.

A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation.
score: 5.9530039, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2000, Yagita, M et. al.

Genetic alterations in the Catnb gene but not the H- ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F 1 mice following exposure to diethanolamine for 2 years
score: 5.9468458, Chemico-Biological Interactions, 2003, Hayashi, Shim-mo et. al.

Classifying the medulloblastoma: insights from morphology and molecular genetics.
score: 5.9340693, Neuropathology and applied neurobiology, 2002, Ellison, D

Gene Dysregulations Driven by Somatic Copy Number Aberrations-Biological and Clinical Implications in Colon Tumors
score: 5.9162951, The Journal of Molecular Diagnostics, 2010, Bacolod, Manny D.; Barany, Francis

Chronic Myelomonocytic Leukemia and Atypical Chronic Myeloid Leukemia: Novel Pathogenetic Lesions
score: 5.9134782, Seminars in Oncology, 2012, Muramatsu, Hideki et. al.

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer
score: 5.9064312, Cancer Metastasis Reviews, 2009, Knowles, Margaret A. et. al.

Genetic Alterations in Colorectal Cancer, Comparative Analysis of Deletion Events, and Point Mutations
score: 5.9039126, Cancer Genetics and Cytogenetics, 1998, el Sebaı̈, Hatem et. al.

Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer.
score: 5.8989197, British journal of cancer, 2009, Souglakos, J et. al.

Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma
score: 5.8932223, BMC Cancer, 2012, Suda, Toshihito et. al.

Cytogenetics and genetics of human cancer: methods and accomplishments
score: 5.859276, Cancer Genetics and Cytogenetics, 2010, Sandberg, Avery A.; Meloni-Ehrig, Aurelia M.

Molecular pathology and its diagnostic use in bone tumors
score: 5.8589257, Cancer Genetics, 2012, Szuhai, Karoly et. al.

Molecular pathology and its diagnostic use in bone tumors
score: 5.8589257, Cancer Genetics, 2012, Szuhai, Karoly et. al.

Resistance to tyrosine kinase inhibitors: Calling on extra forces
score: 5.8556412, Drug Resistance Updates, 2005, Cools, Jan; Maertens, Chantal; Marynen, Peter

Molecular mechanisms underlying human synovial sarcoma development.
score: 5.8527593, Genes, chromosomes & cancer, 2001, dos Santos, N R; de Bruijn, D R; van Kessel, A G

Molecular Diagnosis of Mast Cell Disorders
score: 5.8514917, The Journal of Molecular Diagnostics, 2006, Akin, Cem

Distinct genomic aberrations associated with ERG rearranged prostate cancer.
score: 5.8468317, Genes, chromosomes & cancer, 2009, Demichelis, Francesca et. al.

Impact of EGFR mutation analysis in non-small cell lung cancer
score: 5.838789, Lung Cancer, 2009, Yamamoto, Hiromasa; Toyooka, Shinichi; Mitsudomi, Tetsuya

In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.
score: 5.835961, Molecular cancer therapeutics, 2008, Ikediobi, Ogechi N et. al.

Mutant Transcription Factors and Tyrosine Kinases as Therapeutic Targets for Leukemias: From Acute Promyelocytic Leukemia to Chronic Myeloid Leukemia and Beyond
score: 5.8347891, Advances in Cancer Research, 2007, Hu, Jiong et. al.

Mutant Transcription Factors and Tyrosine Kinases as Therapeutic Targets for Leukemias: From Acute Promyelocytic Leukemia to Chronic Myeloid Leukemia and Beyond
score: 5.8347891, Advances in Cancer Research, 2007, Hu, Jiong et. al.

Searching for molecular targets in sarcoma
score: 5.8299435, Biochemical Pharmacology, 2012, Teicher, Beverly A.

Fusion genes in solid tumors
score: 5.8263357, Seminars in Cancer Biology, 1999, Aman, Pierre

Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2.
score: 5.815973, Cancer research, 1995, Schultz, D C et. al.

Mechanisms of FGFR-mediated carcinogenesis
score: 5.8121132, BBA - Molecular Cell Research, 2012, Ahmad, Imran; Iwata, Tomoko; Leung, Hing Y.

Mechanisms of FGFR-mediated carcinogenesis
score: 5.8121132, BBA - Molecular Cell Research, 2012, Ahmad, Imran; Iwata, Tomoko; Leung, Hing Y.

Establishment and characterization of seven human renal cell carcinoma cell lines.
score: 5.8089582, BJU international, 2000, Shin, K H et. al.

Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT.
score: 5.807237, British journal of cancer, 2007, Brownhill, S C; Taylor, C; Burchill, S A

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
score: 5.8052663, Aging (Albany NY), 2011, Steelman, Linda S. et. al.

Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing
score: 5.8023781, Bioinformatics and Biology Insights, 2007, Kan, Takatsugu et. al.

Trisomy 4 Leading to Duplication of a Mutated KIT Allele in Acute Myeloid Leukemia with Mast Cell Involvement
score: 5.7881408, Cancer Genetics and Cytogenetics, 2000, Beghini, Alessandro et. al.

Integrative Genomic Profiling of Human Prostate Cancer
score: 5.7827219, Cancer Cell, 2010, Taylor, Barry S. et. al.

Hedgehog beyond medulloblastoma and basal cell carcinoma
score: 5.7785898, BBA - Reviews on Cancer, 2010, Teglund, Stephan; Toftgård, Rune

Identification of a novel PTEN intronic deletion in Li-Fraumeni syndrome and its effect on RNA processing
score: 5.7779136, Cancer Genetics and Cytogenetics, 2000, Brown, Lauren T.R; Sexsmith, Elizabeth; Malkin, David

BRAF(E600) in benign and malignant human tumours.
score: 5.7770924, Oncogene, 2008, Michaloglou, C; Vredeveld, L C W; Mooi, W J; Peeper, D S

Immunohistochemical profile and c- kit mutations in gastrointestinal stromal tumors
score: 5.7750351, Pathology - Research and Practice, 2005, Romagnoli, Solange et. al.

Circulating nucleic acids (CNAs) and cancer—A survey
score: 5.7630179, BBA - Reviews on Cancer, 2007, Fleischhacker, M.; Schmidt, B.

Constant p53 Pathway Inactivation in a Large Series of Soft Tissue Sarcomas with Complex Genetics
score: 5.7615234, The American Journal of Pathology, 2010, Pérot, Gaëlle et. al.

Assessment of EGFR Mutation Status in Lung Adenocarcinoma by Immunohistochemistry Using Antibodies Specific to the Two Major Forms of Mutant EGFR
score: 5.7604522, The Journal of Molecular Diagnostics, 2010, Brevet, Marie; Arcila, Maria; Ladanyi, Marc

Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type.
score: 5.758643, British journal of haematology, 2005, Chen, Weina et. al.

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
score: 5.7528914, Oncotarget, 2012, Martelli, Alberto M. et. al.

K-ras mutations and HLA-DR expression in large bowel adenomas.
score: 5.7475083, British Journal of Cancer, 1996, Norheim Andersen, S. et. al.

High-resolution genomic and expression analyses of copy number alterations in breast tumors.
score: 5.7465894, Genes, chromosomes & cancer, 2008, Haverty, Peter M et. al.

Characterization of NPM1-mutated AML with a history of myelodysplastic syndromes or myeloproliferative neoplasms.
score: 5.744468, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Schnittger, S et. al.

Assessment of a fully automated high-throughput DNA extraction method from formalin-fixed, paraffin-embedded tissue for KRAS, and BRAF somatic mutation analysis
score: 5.7273405, Experimental and Molecular Pathology, 2013, van Eijk, Ronald et. al.

Drug development to overcome resistance to EGFR inhibitors in lung and colorectal cancer
score: 5.7273323, Molecular Oncology, 2012, Dienstmann, Rodrigo et. al.

Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene.
score: 5.7236827, Cancer research, 2010, Chen, Zhao et. al.

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma
score: 5.7145171, Cancer Genetics and Cytogenetics, 2004, Sandberg, Avery A.

Broad copy neutral-loss of heterozygosity regions and rare recurring copy number abnormalities in normal karyotype-acute myeloid leukemia genomes.
score: 5.7074966, Genes, chromosomes & cancer, 2010, Barresi, Vincenza et. al.

Comparative analysis of pyrosequencing and QMC-PCR in conjunction with high resolution melting for KRAS/BRAF mutation detection.
score: 5.7065816, International journal of experimental pathology, 2010, Ibrahem, Salih et. al.

Molecular alterations associated with liver metastases development in colorectal cancer patients.
score: 5.7065384, British journal of cancer, 2011, Bruin, S C et. al.

Mutational Analysis of the BRCA1 Tumor Suppressor Gene in Endometrial Carcinoma
score: 5.7008186, Gynecologic Oncology, 1997, Liu, Fu-Shing et. al.

Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas.
score: 5.6978193, Oncogene, 2010, Hadfield, K D et. al.

Fusion genes and chromosome translocations in the common epithelial cancers.
score: 5.6972209, The Journal of pathology, 2010, Edwards, Paul A W

Genetic pathways to colorectal cancer
score: 5.6909608, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2009, Lea, Isabel A.; Jackson, Marcus A.; Dunnick, June K.

The molecular genetics of gastroenteropancreatic neuroendocrine tumors.
score: 5.6907052, Cancer, 2005, Zikusoka, Michelle N et. al.

Molecular genetic aspects of solid tumors in childhood
score: 5.6841192, Seminars in Pediatric Surgery, 2001, Davidoff, Andrew M.; Hill, D.Ashley

Molecular Genetics of Pediatric Soft Tissue Tumors
score: 5.6802319, The Journal of Molecular Diagnostics, 2003, Chang, Chung-Che; Shidham, Vinod B.

Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
score: 5.6782362, PLoS ONE, 2009, MacConaill, Laura E. et. al.

p53 mutations in childhood thyroid tumours from Belarus and in thyroid tumours without radiation history.
score: 5.6669418, International journal of cancer. Journal international du cancer, 1997, Smida, J et. al.

Molecular Diagnosis of Hematopoietic and Lymphoid Neoplasms
score: 5.6597358, Hematology/Oncology Clinics of North America, 2009, Jevremovic, Dragan; Viswanatha, David S.

Kinases as targets in the treatment of solid tumors
score: 5.656409, Cellular Signalling, 2010, Giamas, Georgios et. al.

Molecular Genetics of Renal Cell Carcinoma
score: 5.6562144, Cancer Genetics and Cytogenetics, 1998, Erlandsson, Rikard

Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
score: 5.6525839, Molecular Cancer, 2010, Sierra, J Rafael; Cepero, Virna; Giordano, Silvia

Evidence for the involvement of a potential second tumor suppressor gene on chromosome 17 distinct from p53 in malignant astrocytomas.
score: 5.6505634, Cancer research, 1992, Saxena, A et. al.

Cadherin and catenin alterations in human cancer.
score: 5.6342076, Genes, chromosomes & cancer, 2002, Hajra, Karen M; Fearon, Eric R

Molecular pathogenesis of follicular cell derived thyroid cancers
score: 5.6304416, International Journal of Surgery, 2010, Parameswaran, Rajeev; Brooks, Susan; Sadler, Gregory Paul

Genetics and epigenetics of cutaneous malignant melanoma: A concert out of tune
score: 5.6262802, BBA - Reviews on Cancer, 2012, van den Hurk, Karin et. al.

Genetics and epigenetics of cutaneous malignant melanoma: A concert out of tune
score: 5.6262802, BBA - Reviews on Cancer, 2012, van den Hurk, Karin et. al.

Genetics and epigenetics of cutaneous malignant melanoma: A concert out of tune
score: 5.6262802, BBA - Reviews on Cancer, 2012, van den Hurk, Karin et. al.

New comprehensive denaturing-gradient-gel- electrophoresis assay for KRAS mutation detection applied to paraffin-embedded tumours.
score: 5.6217533, Genes, chromosomes & cancer, 2000, Hayes, V M et. al.

The role of p21 ras in pancreatic neoplasia and chronic pancreatitis
score: 5.6034134, Human Pathology, 1999, Mulligan, Niall J et. al.

Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the TP53 gene.
score: 5.6013957, Genes, chromosomes & cancer, 2002, Tabor, Maarten P et. al.

The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer.
score: 5.6001095, British journal of cancer, 2008, de Graeff, P et. al.

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia
score: 5.5986136, Blood Cancer Journal, 2012, Eriksson, A et. al.

Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study
score: 5.5981823, Journal of Translational Medicine, 2012, Ulivi, Paola et. al.

Rapid KRAS , EGFR , BRAF and PIK3CA Mutation Analysis of Fine Needle Aspirates from Non-Small-Cell Lung Cancer Using Allele-Specific qPCR
score: 5.5972132, PLoS ONE, 2011, van Eijk, Ronald et. al.

Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate
score: 5.5619003, Seminars in Cancer Biology, 2004, Coutré, Steven; Gotlib, Jason

Genetic alterations in cancer knowledge system: analysis of gene mutations in mouse and human liver and lung tumors.
score: 5.5553412, Toxicological sciences : an official journal of the Society of Toxicology, 2006, Jackson, Marcus A et. al.

Mucinous breast carcinomas lack PIK3CA and AKT1 mutations
score: 5.5529384, Human Pathology, 2012, Kehr, Elizabeth L. et. al.

Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate
score: 5.5515523, Seminars in Cancer Biology, 2004, Coutré, Steven; Gotlib, Jason

Abstracts of the AABB Annual Meeting, October 20-23, 2007, Anaheim, California, USA.
score: 5.5513238, Transfusion, 2007,

Comparison of Sanger Sequencing, Pyrosequencing, and Melting Curve Analysis for the Detection of KRAS Mutations
score: 5.5500922, The Journal of Molecular Diagnostics, 2010, Tsiatis, Athanasios C. et. al.

The JAK2 exon 12 mutations: a comprehensive review.
score: 5.5499261, American journal of hematology, 2011, Scott, Linda M

Modern techniques for the diagnostic evaluation of the trephine bone marrow biopsy: Methodological aspects and applications
score: 5.5456202, Progress in Histochemistry and Cytochemistry, 2008, Fend, Falko et. al.

Alterations of the p16 (MTS1) Gene in Testicular, Ovarian, and Endometrial Malignancies
score: 5.5437169, The Journal of Urology, 1995, Hatta, Yoshihiro et. al.

Mutational Determinants of Epigenetic Instablity in Myeloid Malignancies
score: 5.543638, Seminars in Oncology, 2012, Jankowska, Anna M.; Szpurka, Hadrian

IGDB.NSCLC: integrated genomic database of non-small cell lung cancer
score: 5.5414304, Nucleic Acids Research, 2011, Kao, Sen et. al.

A monoclonal antibody IMab-1 specifically recognizes IDH1 R132H, the most common glioma-derived mutation
score: 5.5375687, Biochemical and Biophysical Research Communications, 2009, Kato, Yukinari et. al.

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.
score: 5.5367827, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Damm, F; Nguyen-Khac, F; Fontenay, M; Bernard, O A

Hereditary TP53 Codon 292 and Somatic P16 INK4A Codon 94 Mutations in a Li-Fraumeni Syndrome Family
score: 5.5347119, Cancer Genetics and Cytogenetics, 1999, Güran, Şefik; Tunca, Yusuf; I.mirzalioğlu, Necat

K-ras mutations and HLA-DR expression in large bowel adenomas.
score: 5.5292663, British journal of cancer, 1996, Norheim Andersen, S et. al.

The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
score: 5.5271854, Oncogene, 2001, Clifford, S C et. al.

EGFR and KRAS in Colorectal Cancer
score: 5.5252372, Advances in Clinical Chemistry, 2010, Markman, Ben et. al.

EGFR and KRAS in Colorectal Cancer
score: 5.5252372, Advances in Clinical Chemistry, 2010, Markman, Ben et. al.

Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers.
score: 5.5246591, Genes, chromosomes & cancer, 2007, Liu, Wennuan et. al.

Genetic progression of metastatic melanoma
score: 5.5231308, Cancer Letters, 2004, Rodolfo, Monica; Daniotti, Maria; Vallacchi, Viviana

Loss of heterozygosity and DNA ploidy point to a diverging genetic mechanism in the origin of peripheral and central chondrosarcoma.
score: 5.5216768, Genes, chromosomes & cancer, 1999, Bovée, J V et. al.

Lynch or Not Lynch? Is that Always a Question?
score: 5.5193692, Advances in Cancer Research, 2012, Colas, Chrystelle et. al.

Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
score: 5.5141321, Carcinogenesis, 1997, Yamamoto, S et. al.

Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKCθ expression. Is there any advantage in using several markers?
score: 5.5123323, Pathology - Research and Practice, 2012, Ríos-Moreno, M.J. et. al.

Applications of Genomics in Melanoma Oncogene Discovery
score: 5.5058754, Hematology/Oncology Clinics of North America, 2009, Berger, Michael F.; Garraway, Levi A.

Mucinous Breast Carcinomas Lack PIK3CA and AKT1 Mutations
score: 5.5004692, Human Pathology, 2012, Kehr, Elizabeth L. et. al.

Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use.
score: 5.4977735, Cancer, 1998, Xu, J et. al.

Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancers.
score: 5.489451, British Journal of Cancer, 1998, Jaïs, P. et. al.

Mutational Profiling of Kinases in Human Tumours of Pancreatic Origin Identifies Candidate Cancer Genes in Ductal and Ampulla of Vater Carcinomas
score: 5.4880503, PLoS ONE, 2010, Corbo, Vincenzo et. al.

Causes of microsatellite instability in colorectal tumors
score: 5.4848088, Cancer Genetics and Cytogenetics, 2001, Potočnik, Uroš et. al.

Evaluation of High-Resolution Melting Analysis as a Diagnostic Tool to Detect the BRAF V600E Mutation in Colorectal Tumors
score: 5.4707566, The Journal of Molecular Diagnostics, 2009, Pichler, Martin et. al.

A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma.
score: 5.4679203, Genes, chromosomes & cancer, 2011, Debelenko, Larisa V et. al.

Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas
score: 5.4652238, British Journal of Cancer, 2001, Parry, L et. al.

FLT3 inhibitors in the treatment of acute myeloid leukemia: the start of an era?
score: 5.4630558, Cancer, 2011, Pemmaraju, Naveen et. al.

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines.
score: 5.4567038, Oncogene, 1998, Tsao, H; Zhang, X; Benoit, E; Haluska, F G

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors
score: 5.453554, Cancer Genetics and Cytogenetics, 2002, Sandberg, Avery A; Bridge, Julia A

Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines.
score: 5.4474353, Oncogene, 2004, Melnikova, Vladislava O et. al.

Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer.
score: 5.4443786, British journal of cancer, 2010, Di Fiore, F et. al.

Frequent Occurrence of Loss of Heterozygosity among Tumor Suppressor Genes in Uterine Leiomyosarcoma
score: 5.4383791, Gynecologic Oncology, 1999, Zhai, Ya-Li et. al.

Rapid Polymerase Chain Reaction-Based Detection of Epidermal Growth Factor Receptor Gene Mutations in Lung Adenocarcinomas
score: 5.427612, The Journal of Molecular Diagnostics, 2005, Pan, Qiulu; Pao, William; Ladanyi, Marc

High frequency and heterogeneous distribution of p53 mutations in aflatoxin B1-induced mouse lung tumors.
score: 5.4240331, Cancer research, 1999, Tam, A S et. al.

Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases. The Melanoma Cooperative Group.
score: 5.423412, British journal of cancer, 2000, Palmieri, G et. al.

Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
score: 5.4207975, Cellular Signalling, 2009, Masson, Kristina; Rönnstrand, Lars

Fusion of EWSR1 with the DUX4 facioscapulohumeral muscular dystrophy region resulting from t(4;22)(q35;q12) in a case of embryonal rhabdomyosarcoma
score: 5.4097501, Cancer Genetics and Cytogenetics, 2009, Sirvent, Nicolas et. al.

β-Catenin Dysregulation in Thyroid Neoplasms
score: 5.4088548, The American Journal of Pathology, 2001, Garcia-Rostan, Ginesa et. al.

Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations.
score: 5.4028708, Genes, chromosomes & cancer, 2010, Denayer, Ellen et. al.

Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis
score: 5.3942517, Mutation Research/Reviews in Genetic Toxicology, 1996, Shen, Han-Ming; Ong, Choon-Nam

PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
score: 5.3913314, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Baba, Yoshifumi et. al.

PIK3CA Mutations Frequently Coexist with RAS and BRAF Mutations in Patients with Advanced Cancers
score: 5.3881477, PLoS ONE, 2011, Janku, Filip et. al.

Pathogenesis, classification, and therapy of eosinophilia and eosinophil disorders
score: 5.3858454, Blood Reviews, 2009, Valent, Peter

Loss of CDX2 Expression and Microsatellite Instability Are Prominent Features of Large Cell Minimally Differentiated Carcinomas of the Colon
score: 5.3845713, The American Journal of Pathology, 2001, Hinoi, Takao et. al.

Diet, lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas.
score: 5.3766703, International journal of cancer. Journal international du cancer, 2006, Wark, Petra A et. al.

Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.
score: 5.3764458, British journal of haematology, 2011, Takeda, Yusuke et. al.

Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases.
score: 5.3723057, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2002, Egger, Jean-François et. al.

Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment
score: 5.371468, Mutation Research-Reviews in Mutation Research, 2001, McKinzie, Page B. et. al.

Molecular Diagnosis of Early Pancreatic Ductal Adenocarcinoma in High-Risk Patients
score: 5.3648777, Pancreatology, 2001, Wong, Theresa et. al.

Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site
score: 5.3636035, Molecular Oncology, 2008, Platz, Anton et. al.

Copy Number Alterations and Methylation in Ewing's Sarcoma
score: 5.3565217, Sarcoma, 2011, Jahromi, Mona S.; Jones, Kevin B.; Schiffman, Joshua D.

A comprehensive survey of Ras mutations in cancer.
score: 5.3527073, Cancer research, 2012, Prior, Ian A; Lewis, Paul D; Mattos, Carla

Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.
score: 5.3525271, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2009, Catasus, Lluis et. al.

Interstitial cells of Cajal in health and disease. Part II: ICC and gastrointestinal stromal tumours.
score: 5.3462894, Histopathology, 2007, Streutker, C J; Huizinga, J D; Driman, D K; Riddell, R H

Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression
score: 5.3462555, Journal of Biomedicine and Biotechnology, 2010, Cui, Wei et. al.

PTEN signaling pathways in melanoma.
score: 5.3446795, Oncogene, 2003, Wu, Heng; Goel, Vikas; Haluska, Frank G

Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib
score: 5.3391355, Leukemia Research, 2010, Paquette, Ronald L. et. al.

Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development.
score: 5.3330468, Cancer research, 2001, Pollock, P M; Welch, J; Hayward, N K

Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas.
score: 5.3259383, The Journal of pathology, 2004, Koch, Arend et. al.

Gastrointestinal Mesenchymal Neoplasms other than Gastrointestinal Stromal Tumors: Focusing on Their Molecular Aspects
score: 5.3244265, Pathology Research International, 2011, Plesec, Thomas P.

Concordance in KRAS and BRAF mutations in endoscopic biopsy samples and resection specimens of colorectal adenocarcinoma
score: 5.3164622, European Journal of Cancer, 2012, Krol, L.C. et. al.

KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)
score: 5.3115534, Seminars in Diagnostic Pathology, 2006, Lasota, Jerzy; Miettinen, Markku

Development of a Novel, Fully-Automated Genotyping System: Principle and Applications
score: 5.3058326, Sensors (Basel, Switzerland), 2012, Suzuki, Shun-ichi et. al.

Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT
score: 5.296325, British Journal of Cancer, 2007, Brownhill, S C; Taylor, C; Burchill, S A

NotFound
score: 5.292959, Pathology - Research and Practice, 1995,

A Virtual Pyrogram Generator to Resolve Complex Pyrosequencing Results
score: 5.2854717, The Journal of Molecular Diagnostics, 2012, Chen, Guoli et. al.

Chromosomes, genes, and development of testicular germ cell tumors
score: 5.2762019, Cancer Genetics and Cytogenetics, 2004, Edler von Eyben, Finn

Tyrosine kinase inhibitors
score: 5.2750682, Cancer Cell, 2004, Arteaga, Carlos L.; Baselga, Jose

Gene-Expression Profiling Predicts Recurrence in Dukes’ C Colorectal Cancer
score: 5.2717189, Gastroenterology, 2005, Arango, Diego et. al.

Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancers.
score: 5.2712089, British journal of cancer, 1998, Jaïs, P et. al.

Imatinib treatment for gastrointestinal stromal tumour (GIST).
score: 5.267941, Journal of cellular and molecular medicine, 2010, Lopes, Lisandro F; Bacchi, Carlos E

RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation.
score: 5.2669449, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Kuo, M-C et. al.

The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer
score: 5.2666695, British Journal of Cancer, 2008, de Graeff, P et. al.

Use of multivariate analysis to suggest a new molecular classification of colorectal cancer
score: 5.2628296, The Journal of Pathology, 2013, Domingo, Enric et. al.

SCREENING FOR EARLY PANCREATIC DUCTAL ADENOCARCINOMA IN HEREDITARY PANCREATITIS
score: 5.2615887, Medical Clinics of North America, 2000, Howes, Nathan; Greenhalf, William; Neoptolemos, John

Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification.
score: 5.2607683, Journal of the National Cancer Institute, 1994, Habuchi, T et. al.

Constitutional p53 mutations associated with brain tumors in young adults
score: 5.259875, Cancer Genetics and Cytogenetics, 1995, Chen, Pengchin et. al.

Targeting epidermal growth factor receptor: Central signaling kinase in lung cancer
score: 5.2572079, Biochemical Pharmacology, 2010, Yoshida, Takeshi; Zhang, Guolin; Haura, Eric B.

KRAS and BRAF mutations in sinonasal cancer
score: 5.2565299, Oral Oncology, 2012, López, Fernando et. al.

Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis.
score: 5.2508784, Genes, chromosomes & cancer, 2003, Miyakura, Yasuyuki et. al.

KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants
score: 5.2475606, Human Pathology, 2008, Lasota, Jerzy et. al.

Alterations in the K-ras and p53 genes in rat lung tumors.
score: 5.2400293, Environmental Health Perspectives, 1997, Belinsky, S A et. al.

p53 gene mutation spectrum in hepatocellular carcinoma.
score: 5.2382733, Cancer research, 1992, Oda, T; Tsuda, H; Scarpa, A; Sakamoto, M; Hirohashi, S

Main roads to melanoma
score: 5.2360211, Journal of Translational Medicine, 2009, Palmieri, Giuseppe et. al.

Expression of p21WAF1/CIP1 is unrelated to p53 tumour suppressor gene status in oral squamous cell carcinomas
score: 5.2349967, Oral Oncology, 1998, Yook, J.I; Kim, J

Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia.
score: 5.2328812, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Swords, R; Freeman, C; Giles, F

Features of Colorectal Cancers with High-Level Microsatellite Instability Occurring in Familial and Sporadic Settings
score: 5.2298825, The American Journal of Pathology, 2001, Young, Joanne et. al.

PIK3CA mutations and copy number gains in human lung cancers.
score: 5.2297609, Cancer research, 2008, Yamamoto, Hiromasa et. al.

Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective
score: 5.2294276, Cancer Treatment Reviews, 2000, Sakorafas, G.H.; Tsiotou, A.G.; Tsiotos, G.G.

Gene expression profiling in MDS and AML: potential and future avenues.
score: 5.2284897, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Theilgaard-Mönch, K et. al.

Mutations galore in myeloproliferative neoplasms: would the real Spartacus please stand up?
score: 5.2228107, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Tefferi, A

Molecular Definition of Chromosome Translocations Involving 10q24 and 19q13 in Human Malignant Glioma Cells
score: 5.2179608, Cancer Genetics and Cytogenetics, 1998, Chernova, Olga; Cowell, John K.

Neurofibromatosis type 1-associated tumours: Their somatic mutational spectrum and pathogenesis
score: 5.2151294, Human Genomics, 2011, Spyk, Sebastian Laycock-van et. al.

DNA fingerprinting techniques for the analysis of genetic and epigenetic alterations in colorectal cancer
score: 5.213617, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2010, Samuelsson, Johanna K. et. al.

Predictive factors associated with prolonged survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib
score: 5.2129557, British Journal of Cancer, 2007, Satouchi, M et. al.

p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation.
score: 5.2108622, British Journal of Cancer, 1998, Honda, K. et. al.

Expression of a Mutant p53 Results in an Age-Related Demographic Shift in Spontaneous Lung Tumor Formation in Transgenic Mice
score: 5.2055263, PLoS ONE, 2009, Duan, Wenrui et. al.

Colorectal carcinogenesis: From chromosomal evolution pathways to molecular pathogenesis
score: 5.2034225, Cancer Genetics and Cytogenetics, 1997, Remvikos, Y.; Muleris, M.; Salmon, R.J.; Dutrillaux, B.

EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy.
score: 5.2024207, Oncogene, 2007, Irmer, D; Funk, J O; Blaukat, A

Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.
score: 5.1848074, Oncogene, 1999, Bilanges, B et. al.

Relevance, Pathogenesis, and Testing Algorithm for Mismatch Repair–Defective Colorectal Carcinomas
score: 5.1825069, The Journal of Molecular Diagnostics, 2012, Funkhouser, William K. et. al.

Activity (transcription) of the genes for MLH1, MSH2 and p53 in sporadic colorectal tumours with micro-satellite instability.
score: 5.1820977, British journal of cancer, 2004, Tou, S I H; Drye, E R; Boulos, P B; Hollingsworth, S J

KRAS Mutations
score: 5.1805569, The Journal of Molecular Diagnostics, 2008, Riely, Gregory J.; Ladanyi, Marc

DHPLC is a highly sensitive and rapid screening method to detect BRAFV600Emutation in papillary thyroid carcinoma
score: 5.1800386, Experimental and Molecular Pathology, 2013, Kim, Tae Eun et. al.

DHPLC is a highly sensitive and rapid screening method to detect BRAFV600E mutation in papillary thyroid carcinoma
score: 5.1800386, Experimental and Molecular Pathology, 2013, Kim, Tae Eun et. al.

Molecular modeling and description of a newly characterized activating mutation of the EGFR gene in non-small cell lung cancer
score: 5.176068, Diagnostic Pathology, 2012, Otto, Claudia et. al.

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.
score: 5.1497904, Cancer research, 1998, Ahnen, D J et. al.

Analysis of the genome to personalize therapy for melanoma.
score: 5.1471344, Oncogene, 2010, Davies, M A; Samuels, Y

Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma.
score: 5.1456404, International journal of cancer. Journal international du cancer, 2005, Aust, Daniela E et. al.

Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: a study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group.
score: 5.1392629, Genes, chromosomes & cancer, 2008, Roberts, Paul et. al.

Pathology of Soft Tissue Sarcomas
score: 5.1344697, Clinical Oncology, 2009, Thway, K.

Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias.
score: 5.1288602, Leukemia, 2008, Gotlib, J; Cools, J

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
score: 5.1203369, Breast Cancer Research : BCR, 2008, Marty, Bérengère et. al.

Prognostic impact of INK4A deletion in Ewing sarcoma.
score: 5.1195461, Cancer, 2000, Wei, G et. al.

Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.
score: 5.1181708, Oncogene, 2005, Di Vizio, Dolores et. al.

Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer
score: 5.1173325, BMC Medical Genetics, 2010, Yunxia, Zuo et. al.

Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination.
score: 5.1137427, Pigment cell & melanoma research, 2010, Nakayama, Koh

Aberrant cytokine signaling in leukemia.
score: 5.1120008, Oncogene, 2007, Van Etten, R A

p53 mutations in malignant gliomas.
score: 5.1116466, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998, Li, Y et. al.

Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60.
score: 5.1101376, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1997, Zavadil, J et. al.

The decrease of JAK2 V617F allele burden in leukemia transformation of an elderly patient with myelofibrosis
score: 5.1040985, Leukemia Research, 2009, Zhang, Su-Jiang et. al.

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).
score: 5.098297, Genes, chromosomes & cancer, 2009, Chapman, Emma J et. al.

High frequency of somatic missense mutation of BRCA2 in female breast cancer from Taiwan
score: 5.0982937, Cancer Letters, 2005, Chen, Fang-Ming et. al.

Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype.
score: 5.0967389, Oncogene, 2005, Neben, Kai et. al.

Somatic point mutation of the wild-type allele detected in tumors of patients with VHL germline deletion.
score: 5.0941315, Oncogene, 2002, Vortmeyer, Alexander O et. al.

There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability.
score: 5.0840924, Genes, chromosomes & cancer, 2003, Barnetson, Rebecca et. al.

Mutant KRAS, chromosomal instability and prognosis in colorectal cancer
score: 5.083173, BBA - Reviews on Cancer, 2005, Castagnola, Patrizio; Giaretti, Walter

Somatic Mutation of the Tuberous Sclerosis (Tsc2) Tumor Suppressor Gene in Chemically Induced Rat Renal Carcinoma Cell
score: 5.0822729, The Journal of Urology, 1997, Urakami, Shinji et. al.

Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions.
score: 5.0768406, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Troxell, Megan L et. al.

Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: A reliable and powerful diagnostic tool for pathologists
score: 5.074165, Human Pathology, 2001, Guillou, Louis et. al.

Identification of a potential "hotspot" DNA region in the RUNX1 gene targeted by mitoxantrone in therapy-related acute myeloid leukemia with t(16;21) translocation.
score: 5.0688383, Genes, chromosomes & cancer, 2009, Ottone, Tiziana et. al.

APC gene mutations and allelic losses in sporadic ampullary tumours: evidence of genetic difference from tumours associated with familial adenomatous polyposis.
score: 5.0674532, International journal of cancer. Journal international du cancer, 1996, Achille, A et. al.

Compilation of published comparative genomic hybridization studies
score: 5.0599021, Cancer Genetics and Cytogenetics, 2002, Struski, Stéphanie et. al.

Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.
score: 5.0578893, Genes, chromosomes & cancer, 2012, Persson, Marta et. al.

Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases
score: 5.0496869, British Journal of Cancer, 2000, Palmieri, G et. al.

Absence of p53 gene mutations in primary neuroblastomas.
score: 5.0409691, Cancer research, 1993, Vogan, K et. al.

Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
score: 5.0382388, British Journal of Cancer, 1995, Kiaris, H. et. al.

Current findings for recurring mutations in acute myeloid leukemia
score: 5.0326045, Journal of Hematology & Oncology, 2011, Takahashi, Shinichiro

Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines.
score: 5.0323224, British journal of pharmacology, 2009, Dahan, Laetitia et. al.

Detection of EML4-ALK fusion genes in a few cancer cells from transbronchial cytological specimens utilizing immediate cytology during bronchoscopy
score: 5.0322372, Lung Cancer, 2012, Kanaji, Nobuhiro et. al.

DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation.
score: 5.0316231, Genes, chromosomes & cancer, 2007, Rajaram, Veena et. al.

Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.
score: 5.0265878, Carcinogenesis, 1999, Wei, S J et. al.

Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.
score: 5.022137, Cancer research, 1994, Hegi, M E et. al.

p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma
score: 5.0165592, Human Pathology, 1994, Harpaz, Noam et. al.

Targeting receptor tyrosine kinase signaling in acute myeloid leukemia
score: 5.0131072, Critical Reviews in Oncology and Hematology, 2007, Doepfner, Kathrin T.; Boller, Danielle; Arcaro, Alexandre

CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.
score: 5.0083172, International journal of cancer. Journal international du cancer, 2010, Firestein, Ron et. al.

Pharmaceutical biotechnology
score: 5.00397, Current Opinion in Biotechnology, 1995,

Overexpression of cyclin D1, D3, and p21 in an infantile renal carcinoma with Xp11.2 TFE3-gene fusion
score: 4.999571, Pathology - Research and Practice, 2008, Müller-Höcker, J.; Babaryka, G.; Schmid, I.; Jung, A.

Characterization of chromosome arm 20q abnormalities in myeloid malignancies using genome-wide single nucleotide polymorphism array analysis.
score: 4.9971493, Genes, chromosomes & cancer, 2010, Huh, Jungwon et. al.

The Myelodysplastic Syndromes: Diagnosis and Treatment
score: 4.9940233, Mayo Clinic Proceedings, 2006, Steensma, David P.; Bennett, John M.

The Myelodysplastic Syndromes: Diagnosis and Treatment
score: 4.9940233, Mayo Clinic Proceedings, 2006, Steensma, David P.; Bennett, John M.

Mutations of the p53 tumour suppressor gene in haematologic neoplasms.
score: 4.9935021, British journal of haematology, 1992, Mori, N et. al.

p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation.
score: 4.9926202, British journal of cancer, 1998, Honda, K et. al.

Thyroid Cancer: Current Molecular Perspectives
score: 4.9914146, Journal of Oncology, 2010, Giusti, Francesca et. al.

JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival.
score: 4.9866883, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Tefferi, A et. al.

Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
score: 4.9865021, Cancer research, 2007, Martin, Eric S et. al.

A Rapid, Sensitive Assay to Detect EGFR Mutation in Small Biopsy Specimens from Lung Cancer
score: 4.9859733, The Journal of Molecular Diagnostics, 2006, Yatabe, Yasushi et. al.

Tyrosine kinase activating mutations in human malignancies: Implications for diagnostic pathology
score: 4.9859717, Experimental and Molecular Pathology, 2008, Holden, Joseph A. et. al.

Updates on cytogenetics and molecular genetics of bone and soft tissue tumors:
score: 4.9814341, Cancer Genetics and Cytogenetics, 2000, Sandberg, Avery A; Bridge, Julia A

The promise of telomere length, telomerase activity and its regulation in the translocation-dependent cancer ESFT; clinical challenges and utility
score: 4.977275, BBA - Molecular Basis of Disease, 2009, Proctor, Andrew; Brownhill, Samantha C.; Burchill, Susan A.

Molecular changes in prostatic cancer
score: 4.976902, Surgical Oncology, 2005, Bott, S.R.J.; Arya, M.; Shergill, I.S.; Williamson, M.

Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers
score: 4.9745621, BMC Cancer, 2007, Liu, Yang et. al.

High Resolution Melting Analysis for JAK2 Exon 14 and Exon 12 Mutations
score: 4.9710643, The Journal of Molecular Diagnostics, 2009, Rapado, Inmaculada et. al.

Oncologist's/haematologist's view on the roles of pathologists for molecular targeted cancer therapy.
score: 4.9688838, Journal of cellular and molecular medicine, 2010, Keller, Ulrich et. al.

Translating insights from the cancer genome into clinical practice.
score: 4.9678068, Nature, 2008, Chin, Lynda; Gray, Joe W

Sporadic multiple primary melanoma cases: CDKN2A germline mutations with a founder effect.
score: 4.9660198, Genes, chromosomes & cancer, 2001, Auroy, S et. al.

Chromosomal translocations in cancer
score: 4.9490695, BBA - Reviews on Cancer, 2008, Nambiar, Mridula; Kari, Vijayalakshmi; Raghavan, Sathees C.

Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma
score: 4.942235, Cancer Genetics, 2012, Jahromi, Mona S. et. al.

K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
score: 4.9415157, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2012, Mannan, Abdul; Hahn-Strömberg, Victoria

Adamantinoma-like Ewing's sarcoma and Ewing's-like adamantinoma. The t(11; 22), t(21; 22) status.
score: 4.9375076, The Journal of pathology, 2001, Hauben, E; van den Broek, L C; Van Marck, E; Hogendoorn, P C

Patterns of somatic mutation in human cancer genomes.
score: 4.9357775, Nature, 2007, Greenman, Christopher et. al.

Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients
score: 4.9331858, BMC Cancer, 2012, Mekenkamp, Leonie JM et. al.

Cytogenetics and the surgeon: an invaluable tool in diagnosis, prognosis and counselling of patients with solid tumours.
score: 4.9299375, The British journal of surgery, 1998, Humphrey, G M et. al.

Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer.
score: 4.927063, Journal of cellular biochemistry, 2010, Chen, Jiezhong; Huang, Xu-Feng; Katsifis, Andrew

Alterations of β-Catenin Pathway in Non-Melanoma Skin Tumors
score: 4.9248088, The American Journal of Pathology, 2003, Doglioni, Claudio et. al.

The JAK2 V617F Tyrosine Kinase Mutation in Myeloproliferative Disorders: Status Report and Immediate Implications for Disease Classification and Diagnosis
score: 4.9225063, Mayo Clinic Proceedings, 2005, Tefferi, Ayalew; Gilliland, D. Gary

The JAK2 V617F Tyrosine Kinase Mutation in Myeloproliferative Disorders: Status Report and Immediate Implications for Disease Classification and Diagnosis
score: 4.9225063, Mayo Clinic Proceedings, 2005, Tefferi, Ayalew; Gilliland, D. Gary

MDM2 and CDK4 gene amplification in Ewing's sarcoma.
score: 4.9196758, The Journal of pathology, 1995, Ladanyi, M et. al.

Primary intracranial Ewing sarcoma with an unusually aggressive course: a case report and review of the literature.
score: 4.9180502, Neuropathology : official journal of the Japanese Society of Neuropathology, 2012, Tanboon, Jantima et. al.

The molecular genetics of pancreatic cancer
score: 4.9171326, Surgical Oncology, 1997, Howe, James R.; Conlon, Kevin C.

The role of MYH and microsatellite instability in the development of sporadic colorectal cancer
score: 4.9142694, British Journal of Cancer, 2006, Colebatch, A et. al.

EGFR amplification and lack of activating mutations in metaplastic breast carcinomas.
score: 4.9136932, The Journal of pathology, 2006, Reis-Filho, J S et. al.

Correlation between p53 mutation and cyclin D1 amplification in head and neck squamous cell carcinoma
score: 4.9132515, Oral Oncology, 1997, Mineta, H. et. al.

PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.
score: 4.9128293, Cancer research, 2008, Jhawer, Minaxi et. al.

New cytokine-dependent acute myeloid leukemia cell line MUTZ-11 with disomic chromosome rearrangement t(16;17)
score: 4.9123189, Leukemia Research, 2004, Hu, Zhen-Bo et. al.

Development of molecularly targeted therapies in biliary tract cancers: reassessing the challenges and opportunities.
score: 4.9099681, Hepatology (Baltimore, Md.), 2011, Zhu, Andrew X; Hezel, Aram F

Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients
score: 4.909855, Multidisciplinary Respiratory Medicine, 2012, Obradovic, Jasmina; Jurisic, Vladimir

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
score: 4.903621, BBA - Molecular Cell Research, 2007, McCubrey, James A. et. al.

The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development
score: 4.9034331, The Journal of Experimental Medicine, 2012, Rossi, Davide et. al.

Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond
score: 4.9022301, Drug Design, Development and Therapy, 2011, Ou, Sai-Hong Ignatius

Systemic mastocytosis with associated clonal hematological non-mast-cell lineage disease: A case review.
score: 4.8978132, American journal of hematology, 2011, Ustun, Celalettin et. al.

Prognostic Parameters for the Primary Care of Melanoma Patients: What Is Really Risky in Melanoma?
score: 4.8974993, Journal of Skin Cancer, 2011, Göppner, Daniela; Leverkus, Martin

Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.
score: 4.8956695, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Besaratinia, Ahmad; Pfeifer, Gerd P

New pieces of a puzzle: The current biological picture of MPN
score: 4.895146, BBA - Reviews on Cancer, 2012, Kleppe, Maria; Levine, Ross L.

Molecular Classification and Correlates in Colorectal Cancer
score: 4.89277, The Journal of Molecular Diagnostics, 2008, Ogino, Shuji; Goel, Ajay

Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
score: 4.8886052, Genes, chromosomes & cancer, 2012, Chmielecki, Juliann et. al.

p53 Alterations and protein accumulation in benign breast tissue and breast cancer risk: a cohort study.
score: 4.8881713, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Rohan, Thomas E et. al.

FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia.
score: 4.8881422, Stem cells (Dayton, Ohio), 2006, Parcells, Bertrand W et. al.

KRAS and BRAF Mutation Analysis in Routine Molecular Diagnostics
score: 4.88652, The Journal of Molecular Diagnostics, 2012, Heideman, Daniëlle A.M. et. al.

Guideline for the diagnosis and management of myelofibrosis.
score: 4.8858102, British journal of haematology, 2012, Reilly, John T et. al.

Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma
score: 4.8844122, Histopathology, 2011, Stefanius, Karoliina et. al.

K-ras as a target for cancer therapy
score: 4.8779638, BBA - Reviews on Cancer, 2005, Friday, Bret B.; Adjei, Alex A.

Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1
score: 4.8767824, Lancet Oncology, 2009, Brems, Hilde; Beert, Eline; de Ravel, Thomy; Legius, Eric

Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime
score: 4.8734188, Journal of Medical Genetics, 2012, Forsberg, Lars Anders; Absher, Devin; Dumanski, Jan Piotr

Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.
score: 4.8732785, Oncogene, 2010, Cooke, S L et. al.

Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability
score: 4.8728825, BMC Cancer, 2008, Korff, Sebastian et. al.

Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level.
score: 4.8721521, British journal of cancer, 2012, Sakaizawa, K et. al.

Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
score: 4.8700605, British Journal of Cancer, 1995, Shi, C. Y. et. al.

Altered expression of cell cycle regulatory proteins in gastrointestinal stromal tumors: markers with potential prognostic implications
score: 4.8680697, Human Pathology, 2006, Sabah, Muna; Cummins, Robert; Leader, Mary; Kay, Elaine

CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
score: 4.8590166, Oncogene, 2004, Irimia, Manuel et. al.

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis.
score: 4.8583791, Cell death & disease, 2011, Ahmad, I et. al.

Systemic Mastocytosis
score: 4.8579453, Advances in Immunology, 2006, Robyn, Jamie; Metcalfe, Dean D.

Systemic Mastocytosis
score: 4.8579453, Advances in Immunology, 2006, Robyn, Jamie; Metcalfe, Dean D.

Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas
score: 4.8561332, Human Pathology, 2007, Kondo, Tetsuo et. al.

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.
score: 4.852407, Oncogene, 2009, Chitale, D et. al.

BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications
score: 4.8508865, PLoS ONE, 2011, Dias-Santagata, Dora et. al.

A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart.
score: 4.849925, Genes, chromosomes & cancer, 2012, Bahrami, Armita et. al.

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR -mutant tumors
score: 4.8494399, Oncogene, 2009, Chitale, Dhananjay et. al.

Molecular Diagnosis of Clear Cell Sarcoma
score: 4.8490783, The Journal of Molecular Diagnostics, 2002, Antonescu, Cristina R. et. al.

H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
score: 4.8461068, Oncogene, 2006, Castro, P et. al.

Aneuploidy Arises at Early Stages of Apc-Driven Intestinal Tumorigenesis and Pinpoints Conserved Chromosomal Loci of Allelic Imbalance between Mouse and Human
score: 4.8435264, The American Journal of Pathology, 2007, Alberici, Paola et. al.

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2
score: 4.8430282, The Journal of Experimental Medicine, 2012, Kaufmann, Kai B. et. al.

Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.
score: 4.8418008, Cancer research, 1990, Goodrow, T; Reynolds, S; Maronpot, R; Anderson, M

Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer.
score: 4.8410438, Cancer research, 2009, Kikuchi, Hirotoshi et. al.

EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset.
score: 4.8405358, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2009, Inamura, Kentaro et. al.

Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking status.
score: 4.8402906, Cancer, 1999, Berger, D H et. al.

Using genetics and genomics strategies to personalize therapy for cancer: Focus on melanoma
score: 4.8400685, Biochemical Pharmacology, 2010, Nathanson, Katherine L.

Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas
score: 4.8345507, European Journal of Cancer, 1996, Hagel, C. et. al.

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
score: 4.8271834, Oncogene, 2004, Osato, Motomi

Progression of BRAF -induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling
score: 4.826371, Oncogene, 2011, Knauf, Jeffrey A et. al.

Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas.
score: 4.8261259, Genes, chromosomes & cancer, 2000, Kurose, K; Zhou, X P; Araki, T; Eng, C

p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.
score: 4.8216069, Cancer research, 1992, von Deimling, A et. al.

Correlation of p53 mutations in ThinPrep-processed fine needle breast aspirates with surgically resected breast cancers.
score: 4.8215929, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2000, Pollett, A; Bedard, Y C; Li, S Q; Rohan, T; Kandel, R

Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
score: 4.8199967, British journal of cancer, 1995, Kiaris, H et. al.

Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas.
score: 4.8197458, Oncogene, 2003, Benn, Diana E et. al.

Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
score: 4.8183337, Human mutation, 2012, Upadhyaya, Meena et. al.

Pathobiologic Markers of the Ewing Sarcoma Family of Tumors: State of the Art and Prediction of Behaviour
score: 4.8159645, Sarcoma, 2010, Pinto, Alfredo; Dickman, Paul; Parham, David

Modern diagnostics in acute leukemias
score: 4.8158294, Critical Reviews in Oncology and Hematology, 2005, Haferlach, Torsten et. al.

Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.
score: 4.8138902, Proceedings of the National Academy of Sciences of the United States of America, 1991, Meltzer, S J et. al.

Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
score: 4.8131153, Cancer research, 2010, Dewaele, Barbara et. al.

Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer.
score: 4.8106404, The Journal of pathology, 2008, Barber, M et. al.

Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability.
score: 4.8089781, The Journal of pathology, 2009, Kang, Mi Ran et. al.

p53 in head and neck cancer: Functional consequences and environmental implications of TP53 mutations
score: 4.8082263, Head & Neck Oncology, 2010, Peltonen, Jenni K et. al.

Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis.
score: 4.8079221, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Bullinger, L et. al.

Potential role of a navigator gene NAV3 in colorectal cancer.
score: 4.8050105, British journal of cancer, 2012, Carlsson, E et. al.

Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours
score: 4.802844, Oncology Reports, 2012, CAPODANNO, ALESSANDRA et. al.

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors
score: 4.8015854, Cancer Genetics and Cytogenetics, 2001, Sandberg, Avery A; Bridge, Julia A

Janus Kinase Deregulation in Leukemia and Lymphoma
score: 4.8013075, Immunity, 2012, Chen, Edwin; Staudt, Louis M.; Green, Anthony R.

Recurrent IDH mutations in high-risk myelodysplastic syndrome or acute myeloid leukemia with isolated del(5q).
score: 4.79755, Leukemia, 2010, Pardanani, A et. al.

Synovial sarcoma of the kidney
score: 4.7973943, Annals of Diagnostic Pathology, 2008, Divetia, Mukul et. al.

Prognostic factors in AML in relation to (ab)normal karyotype
score: 4.7970267, Best Practice & Research Clinical Haematology, 2009, Stone, Richard M.

Analysis of Ki-ras and p53 gene mutations in laterally spreading tumors of the colorectum.
score: 4.7965102, Pathology international, 2003, Noro, Akihiro et. al.

Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics
score: 4.7907862, Journal of Hematology & Oncology, 2009, Gregory, Tara K et. al.

Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia.
score: 4.7901668, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Deneberg, S et. al.

Advances in salivary gland pathology.
score: 4.7894914, Histopathology, 2007, Cheuk, W; Chan, J K C

KRAS Mutation Screening in Colorectal Cancer: From Paper to Practice
score: 4.7866945, Clinical Colorectal Cancer, 2010, Fakih, Marwan M.

Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm
score: 4.7838646, Human Pathology, 2009, Tang, Guilin et. al.

ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family?
score: 4.7811501, Genes, chromosomes & cancer, 2001, Sirvent, N et. al.

Targeted KRAS Mutation Assessment on Patient Tumor Histologic Material in Real Time Diagnostics
score: 4.7804974, PLoS ONE, 2009, Kotoula, Vassiliki et. al.

Ki- ras oncogene activation in transplantable rat thyroid carcinoma induced by N-bis(2-hydroxypropyl)nitrosamine
score: 4.7797967, Cancer Letters, 1994, Hiasa, Yoshio et. al.

Genomic Instability and Carcinogenesis: An Update
score: 4.7772167, Current Genomics, 2008, Abdel-Rahman, Wael M

Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond.
score: 4.7736103, Nature reviews. Drug discovery, 2011, Quintás-Cardama, Alfonso et. al.

Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).
score: 4.7713275, Human mutation, 2008, Bentivegna, Steven et. al.

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
score: 4.7688077, Disease models & mechanisms, 2011, Ahmad, Imran et. al.

Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas.
score: 4.7642341, The Journal of pathology, 2010, Geyer, Felipe C et. al.

The role of minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse.
score: 4.7600913, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Bachas, C et. al.

Molecular analysis of thyroid tumors.
score: 4.7592378, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011, Nikiforov, Yuri E

Oncogenes and cell proliferation
score: 4.7591838, Current Opinion in Genetics & Development, 1994,

Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.
score: 4.7589303, Proceedings of the National Academy of Sciences of the United States of America, 2012, Bosbach, Benedikt et. al.

The cancer genome.
score: 4.7566243, Nature, 2009, Stratton, Michael R; Campbell, Peter J; Futreal, P Andrew

Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression.
score: 4.7540855, Proceedings of the National Academy of Sciences of the United States of America, 1997, Weber, R G et. al.

Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma
score: 4.7531908, Cancer Treatment Reviews, 2010, Bronte, Giuseppe et. al.

Clinical significance of ras oncogene activation in human lung cancer.
score: 4.753128, Cancer research, 1992, Rodenhuis, S; Slebos, R J

BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer
score: 4.7520951, Clinical Epigenetics, 2013, van Roon, Eddy H et. al.

Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms.
score: 4.7500159, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Tefferi, A; Vardiman, J W

Poor clinical significance of p53 gene polymorphism in acute myeloid leukemia
score: 4.7496618, Leukemia Research, 2000, Nakano, Yasuyuki et. al.

Are KRAS/BRAF Mutations Potent Prognostic and/or Predictive Biomarkers in Colorectal Cancers?
score: 4.7488977, Anti-Cancer Agents in Medicinal Chemistry, 2012, Yokota, Tomoya

Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors
score: 4.7432659, Human Pathology, 2007, Sukov, William R. et. al.

Different Subtypes of Human Lung Adenocarcinoma Caused by Different Etiological Factors
score: 4.7420412, The American Journal of Pathology, 2000, Hashimoto, Takehisa et. al.

Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
score: 4.7412966, Lancet Oncology, 2008, Linardou, Helena et. al.

Analysis of p53 and BAX mutations, loss of heterozygosity, p53 and BCL2 expression and apoptosis in basal cell carcinoma in Korean patients.
score: 4.7363093, The British journal of dermatology, 2001, Cho, S; Hahm, J H; Hong, Y S

Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium
score: 4.7359435, Leukemia Research, 2012, Mascarenhas, John et. al.

Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium
score: 4.7359435, Leukemia Research, 2012, Mascarenhas, John et. al.

Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
score: 4.7325802, International Journal of Oncology, 2012, TAYLOR, CLAIRE et. al.

Human bladder carcinoma cell lines as indicators of oncogenic change relevant to urothelial neoplastic progression.
score: 4.7317931, British Journal of Cancer, 1995, Rieger, K. M. et. al.

Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia.
score: 4.7232895, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2006, Pedersen-Bjergaard, J et. al.

Frequent mutations of p53 gene in oesophageal squamous cell carcinomas with and without human papillomavirus (HPV) involvement suggest the dominant role of environmental carcinogens in oesophageal carcinogenesis.
score: 4.7224661, British Journal of Cancer, 1994, Chang, F. et. al.

Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
score: 4.7184485, British Journal of Cancer, 2009, Souglakos, J et. al.

Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers
score: 4.7165238, Cancer Genetics and Cytogenetics, 2007, Brenner, Bruce M. et. al.

Correlation of TP53 Mutations and p53 Expression in Ovarian Tumors
score: 4.7153163, Cancer Genetics and Cytogenetics, 1998, DiCioccio, Richard A. et. al.

Review: genetic models of acute myeloid leukaemia.
score: 4.709632, Oncogene, 2008, McCormack, E; Bruserud, O; Gjertsen, B T

Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1.
score: 4.7049631, Clinical endocrinology, 2002, Ouyang, Bin et. al.

p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer.
score: 4.7039419, Cancer research, 1994, Ryberg, D et. al.

Mitochondrial kinases in cell signaling: Facts and perspectives
score: 4.6990252, Advanced Drug Delivery Reviews, 2009, Arciuch, Valeria G. Antico et. al.

Molecular pathology of thyroid cancer: diagnostic and clinical implications
score: 4.6982471, Best Practice & Research Clinical Endocrinology & Metabolism, 2008, Fagin, James A.; Mitsiades, Nicholas

Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.
score: 4.6979292, Cancer research, 1993, Spruck, C H et. al.

Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas.
score: 4.6948849, Genes, chromosomes & cancer, 2004, Ulaner, Gary A et. al.

Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p.
score: 4.6948215, Genes, chromosomes & cancer, 2006, Aarts, Marieke et. al.

Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis.
score: 4.6925317, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Yanada, M; Matsuo, K; Suzuki, T; Kiyoi, H; Naoe, T

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability
score: 4.6898218, Human Pathology, 2008, Kim, Min Sung et. al.

The testicular germ cell tumour transcriptome.
score: 4.6884355, International journal of andrology, 2011, Alagaratnam, S et. al.

Biallelic Inactivation of Fumarate Hydratase ( FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors
score: 4.6870613, The American Journal of Pathology, 2004, Lehtonen, Rainer et. al.

Sensitive Sequencing Method for KRAS Mutation Detection by Pyrosequencing
score: 4.6861091, The Journal of Molecular Diagnostics, 2005, Ogino, Shuji et. al.

Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma
score: 4.6859144, Gastroenterology, 1994, Simon, Babette et. al.

Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia
score: 4.6829229, Blood Cells, Molecules and Diseases, 2010, Wiemels, Joseph L. et. al.

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
score: 4.6823281, Cell, 1994, Golub, Todd R. et. al.

Presence of p53 mutations in primary nasopharyngeal carcinoma (NPC) in non-Asians of Los Angeles, California, a low-risk population for NPC.
score: 4.6820089, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Van Tornout, J M et. al.

Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas
score: 4.6790653, Human Pathology, 1996, Soong, Richie et. al.

Head and neck tumor sites differ in prevalence and spectrum of p53 alterations but these have limited prognostic value.
score: 4.6774196, International journal of cancer. Journal international du cancer, 2004, Bosch, Franz X et. al.

A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy
score: 4.67664, Experimental Hematology, 2007, Grand, Francis H. et. al.

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder
score: 4.6730881, Disease Models & Mechanisms, 2011, Ahmad, Imran et. al.

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells.
score: 4.6726493, Oncogene, 2012, Yasaei, H et. al.

Somatic pharmacogenomics in cancer.
score: 4.670294, The pharmacogenomics journal, 2008, Ikediobi, O N

Targeted Therapy for Advanced Non-small Cell Lung Cancers: Historical Perspective, Current Practices, and Future Development
score: 4.6643705, Current Problems in Cancer, 2009, Mahalingam, Devalingam et. al.

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice
score: 4.6635681, Gastroenterology, 2000, Smits, Ron et. al.

Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours.
score: 4.6629574, British Journal of Cancer, 1995, Koopmann, J. et. al.

K-ras and p16 INK4A alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers
score: 4.6595376, Lung Cancer, 2004, Destro, A et. al.

Imatinib as a Paradigm of Targeted Therapies
score: 4.6590283, Advances in Cancer Research, 2004, Druker, Brian J.

Imatinib as a Paradigm of Targeted Therapies
score: 4.6590283, Advances in Cancer Research, 2004, Druker, Brian J.

Promoter-hypermethylation associated defective expression of E-cadherin in primary non-small cell lung cancer
score: 4.6547266, Lung Cancer, 2008, Wang, Guiying et. al.

Changed concepts and definitions of myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in the updated 2008 WHO classification
score: 4.6504589, Journal of Hematopathology, 2009, Hebeda, Konnie M.; Fend, F.

The role of MYH and microsatellite instability in the development of sporadic colorectal cancer.
score: 4.6495094, British journal of cancer, 2006, Colebatch, A et. al.

Molecular pathology of sarcomas: concepts and clinical implications
score: 4.6452787, Virchows Archiv, 2009, Bovée, Judith V. M. G.; Hogendoorn, Pancras C. W.

A molecular study of EBV DNA and p53 mutations in nasopharyngeal carcinoma of Saudi Arab patients
score: 4.6447468, Cancer Letters, 1994, Nasrin, Nargis et. al.

Identification of cancer genes by mutational profiling of tumor genomes
score: 4.641551, FEBS Letters, 2005, Benvenuti, Silvia; Arena, Sabrina; Bardelli, Alberto

FLT3: ITDoes matter in leukemia.
score: 4.6407801, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2003, Levis, M; Small, D

DNA profiling analysis of 100 consecutive de novo acute myeloid leukemia cases reveals patterns of genomic instability that affect all cytogenetic risk groups.
score: 4.6406379, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Suela, J et. al.

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
score: 4.6405946, The Journal of Experimental Medicine, 2011, Fabbri, Giulia et. al.

A systematic review of molecular and biological markers in tumours of the Ewing's sarcoma family
score: 4.638299, European Journal of Cancer, 2003, Riley, R.D et. al.

Adult acute myeloid leukaemia
score: 4.6366293, Critical Reviews in Oncology and Hematology, 2004, Smith, Matthew et. al.

Evaluation of TP53 mutations with the AmpliChip p53 research test in chronic lymphocytic leukemia: Correlation with clinical outcome and gene expression profiling.
score: 4.6353698, Genes, chromosomes & cancer, 2011, Chiaretti, Sabina et. al.

Prognostic value of p53 overexpression and c-Ki- ras gene mutations in colorectal cancer
score: 4.6352364, Gastroenterology, 1993, Bell, Sandra M. et. al.

Gastrointestinal stromal tumours: an update.
score: 4.6345808, Histopathology, 2006, Rubin, B P

Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.
score: 4.6291282, Cancer research, 1992, Greenwald, B D et. al.

Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course.
score: 4.6264001, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2003, Lasota, Jerzy et. al.

Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia.
score: 4.6091517, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2003, Morgan, M A; Ganser, A; Reuter, C W M

Abstracts
score: 4.6081703, Experimental Hematology, 2006,

APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis
score: 4.6040429, British Journal of Cancer, 2000, Ficari, F et. al.

Clinical implications of BRAF mutation in thyroid carcinoma
score: 4.6034936, Trends in Endocrinology & Metabolism, 2008, Puxeddu, Efisio et. al.

Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.
score: 4.6008513, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Ono, R et. al.

Malignant inguinal monophasic synovial sarcoma: report of a case and review of the literature
score: 4.5968936, World Journal of Surgical Oncology, 2010, Xu, Ji; Wang, Jia; Cui, Long; Wu, Xiangru

E-Cadherin Gene Mutations Frequently Occur in Synovial Sarcoma as a Determinant of Histological Features
score: 4.596603, The American Journal of Pathology, 2001, Saito, Tsuyoshi et. al.

Omics and therapy – A basis for precision medicine
score: 4.5946582, Molecular Oncology, 2012, Garay, Joseph P.; Gray, Joe W.

Omics and therapy – A basis for precision medicine
score: 4.5946582, Molecular Oncology, 2012, Garay, Joseph P.; Gray, Joe W.

Omics and therapy – A basis for precision medicine
score: 4.5946582, Molecular Oncology, 2012, Garay, Joseph P.; Gray, Joe W.

Activity of pemetrexed and high-dose gefitinib in an EGFR-mutated lung adenocarcinoma with brain and leptomeningeal metastasis after response to gefitinib
score: 4.5925463, World Journal of Surgical Oncology, 2012, Yuan, Ying et. al.

ErbBs in lung cancer
score: 4.5924039, Experimental Cell Research, 2009, Sharma, Sreenath V.; Settleman, Jeffrey

Predictive factors associated with prolonged survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib.
score: 4.5899561, British journal of cancer, 2007, Satouchi, M et. al.

Application of molecular techniques in the diagnosis, prognosis and management of patients with colorectal cancer: a practical approach
score: 4.588611, Human Pathology, 2012, LeGolvan, Mark P.; Taliano, Ross J.; Resnick, Murray B.

p73, a gene related to p53, is not mutated in esophageal carcinomas.
score: 4.5875066, International journal of cancer. Journal international du cancer, 1998, Nimura, Y et. al.

Mast Cells and Eosinophils in Mastocytosis, Chronic Eosinophilic Leukemia, and Non-clonal Disorders
score: 4.5848945, Seminars in Hematology, 2012, Gotlib, Jason; Akin, Cem

Molecular aspects of thymic carcinoma
score: 4.5846278, Lung Cancer, 2012, Weissferdt, Annikka; Wistuba, Ignacio I.; Moran, Cesar A.

Molecular aspects of thymic carcinoma
score: 4.5846278, Lung Cancer, 2012, Weissferdt, Annikka; Wistuba, Ignacio I.; Moran, Cesar A.

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia.
score: 4.5765128, Proceedings of the National Academy of Sciences of the United States of America, 2009, Radtke, Ina et. al.

Genomic and proteomic biomarkers for cancer: A multitude of opportunities
score: 4.5764202, BBA - Reviews on Cancer, 2009, Tainsky, Michael A.

The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system.
score: 4.5725255, British Journal of Cancer, 1998, Fox, J. C. et. al.

Classification and Subtype Prediction of Adult Soft Tissue Sarcoma by Functional Genomics
score: 4.5688718, The American Journal of Pathology, 2003, Segal, Neil H. et. al.

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system
score: 4.5648233, Acta Neuropathologica, 2009, Küsters-Vandevelde, Heidi V. N. et. al.

Intratumoral patterns of genomic imbalance in glioblastomas.
score: 4.564685, Brain pathology (Zurich, Switzerland), 2010, Nobusawa, Sumihito et. al.

Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance
score: 4.5635664, Drug Resistance Updates, 2012, Wilting, Roel H.; Dannenberg, Jan-Hermen

Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease.
score: 4.5609895, Genes, chromosomes & cancer, 2008, Steinemann, Doris et. al.

Ras p21 protein immunoreactivity and its relationship to p53 expression and prognosis in gallbladder and extrahepatic biliary carcinoma
score: 4.5588139, European Journal of Surgical Oncology, 1997, Soon Lee, C.

Somatic mutations of signaling genes in non-small-cell lung cancer
score: 4.5553885, Cancer Genetics and Cytogenetics, 2010, Sanders, Heather R.; Albitar, Maher

Germline and somatic JAK2 mutations and susceptibility to chronic myeloproliferative neoplasms
score: 4.5548269, Genome Medicine, 2009, Goldin, Lynn R et. al.

Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas.
score: 4.5527203, British Journal of Cancer, 1996, Shi, Y.; Zou, M.; Farid, N. R.; al-Sedairy, S. T.

Chromosome 22q alterations and expression of the NF2 gene product, merlin, in gastrointestinal stromal tumors
score: 4.5525287, Human Pathology, 2003, Pylkkänen, Lea et. al.

Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas
score: 4.5478739, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2010, Yamaguchi, Yu et. al.

FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
score: 4.5447762, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Kajiguchi, T et. al.

Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?
score: 4.5427907, Cancer Treatment Reviews, 2010, Rizzo, Sergio et. al.

Myeloproliferative neoplasms 2012: The John M. Bennett 80th birthday anniversary lecture
score: 4.5426002, Leukemia Research, 2012, Tefferi, Ayalew

Myeloproliferative neoplasms 2012: The John M. Bennett 80th birthday anniversary lecture
score: 4.5426002, Leukemia Research, 2012, Tefferi, Ayalew

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.
score: 4.5421368, Nature genetics, 2010, Barretina, Jordi et. al.

Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies.
score: 4.5411494, Cancer science, 2008, Matsumura, Itaru; Mizuki, Masao; Kanakura, Yuzuru

Absence of point mutations at codon 17 of the Mdm2 gene (serine 17) in human primary tumors
score: 4.5402957, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000, Silva, Javier et. al.

Genetic analysis of von Hippel-Lindau disease.
score: 4.5399494, Human mutation, 2010, Nordstrom-O'Brien, Morgan et. al.

Primary pleuropulmonary synovial sarcoma: reappraisal of a recently described anatomic subset.
score: 4.5365659, Cancer, 2002, Essary, Lydia R; Vargas, Sara O; Fletcher, Christopher D M

FLT3 mutations are associated with other molecular lesions in AML
score: 4.5345362, Leukemia Research, 2004, Carnicer, Maria J. et. al.

K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.
score: 4.5321037, Pathology international, 1999, Maeshima, A M; Maeshima, A; Kawashima, O; Nakajima, T

Response to Erlotinib in patients with EGFR mutant advanced non-small cell lung cancers with a squamous or squamous-like component.
score: 4.5320948, Molecular cancer therapeutics, 2012, Paik, Paul K et. al.

PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers
score: 4.5303373, The American Journal of Pathology, 2002, Zhou, Xiao-Ping et. al.

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes
score: 4.5292558, Experimental Hematology, 2012, Novak, Rachel L. et. al.

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes
score: 4.5292558, Experimental Hematology, 2012, Novak, Rachel L. et. al.

Frequent ras gene mutations in squamous cell cervical cancer
score: 4.5291935, Cancer Letters, 1995, Wong, Y.F. et. al.

Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.
score: 4.5274172, Cancer research, 2002, Kiuru, Maija et. al.

Frequent EGFR mutations in brain metastases of lung adenocarcinoma.
score: 4.5248253, International journal of cancer. Journal international du cancer, 2006, Matsumoto, Shingo et. al.

Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1.
score: 4.5229064, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, McKenzie, R C T et. al.

A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical Setting
score: 4.5202031, The Journal of Molecular Diagnostics, 2009, Whitehall, Vicki et. al.

Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines.
score: 4.5181315, Genes, chromosomes & cancer, 2005, Gysin, Stephan et. al.

Anaplastic lymphoma kinase: signalling in development and disease
score: 4.5160262, Biochemical Journal, 2009, Palmer, Ruth H. et. al.

ASH 2010 meeting report-Top 10 clinically-oriented abstracts in myeloproliferative neoplasms.
score: 4.5101773, American journal of hematology, 2011, Tefferi, Ayalew

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
score: 4.5099511, Current Opinion in Pharmacology, 2008, Yap, Timothy A et. al.

Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia.
score: 4.5058184, Genes, chromosomes & cancer, 2004, Safley, Anne Michele et. al.

Frequent mutations of p53 gene in oesophageal squamous cell carcinomas with and without human papillomavirus (HPV) involvement suggest the dominant role of environmental carcinogens in oesophageal carcinogenesis.
score: 4.5042241, British journal of cancer, 1994, Chang, F et. al.

ALK rearrangement in sickle cell trait-associated renal medullary carcinoma.
score: 4.4990338, Genes, chromosomes & cancer, 2011, Mariño-Enríquez, Adrián et. al.

Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level
score: 4.4980712, British Journal of Cancer, 2012, Sakaizawa, K et. al.

Sarcomes des tissus mous : données moléculaires actuelles
score: 4.4939797, Cancer / Radiothérapie, 2006, Bui Nguyen Binh, M.; Collin, F.; Coindre, J.-M.

One-Step Detection of c-kit Point Mutations Using Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping and Hybridization Probes
score: 4.4923453, The American Journal of Pathology, 2003, Sotlar, Karl et. al.

Biology of EWS/ETS fusions in Ewing's family tumors.
score: 4.4905544, Oncogene, 2001, Arvand, A; Denny, C T

Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients.
score: 4.4884488, Cancer research, 1992, Kikuchi-Yanoshita, R et. al.

Guidelines on the management of acute myeloid leukaemia in adults.
score: 4.4870282, British journal of haematology, 2006, British Committee for Standards in Haematology, et. al.

Tumour cells of extramammary Paget's disease do not show either p53 mutation or allelic loss at several selected loci implicated in other cancers.
score: 4.486003, British Journal of Cancer, 1997, Takata, M.; Hatta, N.; Takehara, K.

Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23).
score: 4.4859877, Genes, chromosomes & cancer, 2007, Nemoto, Noriko et. al.

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
score: 4.4839665, Cell, 1996, Hahn, Heidi et. al.

Are DNA mismatch repair deficiencies responsible for accumulation of genetic alterations in epithelial ovarian cancers?
score: 4.4827203, Cancer Genetics and Cytogenetics, 2001, Suzuki, Mitsuaki et. al.

Advances in the analysis of chromosome alterations in human lung carcinomas
score: 4.4772821, Cancer Genetics and Cytogenetics, 1997, Testa, Joseph R. et. al.

Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype
score: 4.4771067, Gene, 2001, Ohmiya, Naoki et. al.

p53 mutations in urinary bladder cancer.
score: 4.4763178, British journal of cancer, 2001, Berggren, P et. al.

KIT regulates tyrosine phosphorylation and nuclear localization of β-catenin in mast cell leukemia
score: 4.4749916, Leukemia Research, 2008, Kajiguchi, Tomohiro et. al.

Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer
score: 4.4732967, JNCI Journal of the National Cancer Institute, 2009, Siena, Salvatore et. al.

p53 gene mutations in Bowen's disease in Koreans: clustering in exon 5 and multiple mutations
score: 4.4718327, Cancer Letters, 2000, Lee, Hyun-Jeong et. al.

Eosinophilic Myeloid Disorders
score: 4.4708474, Seminars in Hematology, 2012, Noel, Pierre

Role of molecular studies in the diagnosis of lung adenocarcinoma.
score: 4.4693001, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Yousem, Samuel A

Histopathological and immunohistochemical features associated with clinical response to neoadjuvant gefitinib therapy in early stage non-small cell lung cancer
score: 4.4685569, Lung Cancer, 2012, Lara-Guerra, Humberto et. al.

Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval.
score: 4.4660218, Genes, chromosomes & cancer, 2004, Walker, Graeme J et. al.

Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene.
score: 4.4637273, Oncogene, 2001, Cheng, C W et. al.

Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases.
score: 4.4617296, British journal of haematology, 2006, Vannucchi, Alessandro M et. al.

Gene Deletions and Amplifications in Human Hepatocellular Carcinomas
score: 4.460304, The American Journal of Pathology, 2012, Nalesnik, Michael A. et. al.

Hypermethylation of the 5′ CpG island of the p14 ARF flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression
score: 4.4593306, Clinical Epigenetics, 2012, Nyiraneza, Christine et. al.

Kinase mutations in human disease: interpreting genotype-phenotype relationships.
score: 4.458447, Nature reviews. Genetics, 2010, Lahiry, Piya et. al.

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors
score: 4.4582711, Cancer Genetics and Cytogenetics, 2003, Sandberg, Avery A; Bridge, Julia A

Chronic idiopathic myelofibrosis (CIMF) resulting from a unique 3;9 translocation disrupting the janus kinase 2 (JAK2) gene
score: 4.4574677, Experimental and Molecular Pathology, 2006, Mark, Hon Fong L. et. al.

Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.
score: 4.4559041, British Journal of Cancer, 1997, Hatta, Y.; Takeuchi, S.; Yokota, J.; Koeffler, H. P.

JAK2 46/1 haplotype analysis in myeloproliferative neoplasms and acute myeloid leukemia.
score: 4.4509833, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Andrikovics, H et. al.

Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array.
score: 4.4493699, Genes, chromosomes & cancer, 2006, Liu, Wennuan et. al.

Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours.
score: 4.4447153, British journal of cancer, 1995, Koopmann, J et. al.

Akt-regulated pathways in prostate cancer.
score: 4.4432632, Oncogene, 2005, Majumder, Pradip K; Sellers, William R

Molecular predictors of response to tyrosine kinase inhibitors in patients with Non-Small-Cell Lung Cancer
score: 4.4396964, Journal of Experimental & Clinical Cancer Research : CR, 2012, Murray, Samuel et. al.

Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers.
score: 4.4315724, Cancer research, 2010, Nagasaka, Takeshi et. al.

Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies.
score: 4.4297738, Journal of cellular and molecular medicine, 2012, Medves, Sandrine; Demoulin, Jean-Baptiste

Molecular genetic analysis of the hepatocyte growth factor/MET signaling pathway in pediatric medulloblastoma.
score: 4.4267105, Genes, chromosomes & cancer, 2012, Onvani, Sara et. al.

Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer.
score: 4.4252732, Oncogene, 2007, Kohonen-Corish, M R J et. al.

A Highly Sensitive Quantitative Real-Time PCR Assay for Determination of Mutant JAK2 Exon 12 Allele Burden
score: 4.4240861, PLoS ONE, 2012, Kjær, Lasse et. al.

Oncogenic Signals as Treatment Targets in Classic Myeloproliferative Neoplasms
score: 4.4226282, Biology of Blood and Marrow Transplantation, 2009, Tefferi, Ayalew; Levine, Ross L.; Kantarjian, Hagop

Frequent low level expression in Ewing sarcoma family tumors and widespread absence of the metastasis suppressor KAI1/CD82 in neuroblastoma.
score: 4.4225645, Pediatric research, 2002, Aryee, Dave N T et. al.

Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.
score: 4.4207428, Proceedings of the National Academy of Sciences of the United States of America, 1999, Efstathiou, J A et. al.

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis.
score: 4.4206655, Oncogene, 2010, Nogueira, C et. al.

Somatic D-loop mitochondrial DNA mutations are frequent in uterine serous carcinoma
score: 4.4205753, European Journal of Cancer, 2004, Pejovic, Tanja et. al.

A new germline TP53 gene mutation in a family with Li-Fraumeni syndrome
score: 4.4204051, European Journal of Cancer, 1996, Dockhorn-dworniczak, B. et. al.

Tumour necrosis and microvascular proliferation are associated with 9p deletion and CDKN2A alterations in 1p/19q-deleted oligodendrogliomas.
score: 4.4177857, Neuropathology and applied neurobiology, 2003, Godfraind, C et. al.

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.
score: 4.4171884, Oncogene, 1997, Kovar, H et. al.

Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis
score: 4.416297, Molecular Oncology, 2007, Herceg, Zdenko; Hainaut, Pierre

Relationship between HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm
score: 4.4125402, Gynecologic Oncology, 2003, Tsuda, Hiroshi et. al.

Identification and characterization of Birt-Hogg-Dubé associated renal carcinoma.
score: 4.410635, The Journal of pathology, 2007, Murakami, T et. al.

Mutation screening for JAK2 V617F: When to order the test and how to interpret the results
score: 4.4105938, Leukemia Research, 2006, Tefferi, Ayalew; Pardanani, Animesh

p53 Point mutations in dysplastic and cancerous ulcerative colitis lesions
score: 4.4092163, Gastroenterology, 1993, Yin, Jing et. al.

Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.
score: 4.4040445, Human molecular genetics, 1999, Richards, F M et. al.

Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells
score: 4.4036492, PLoS ONE, 2009, Soh, Junichi et. al.

Expression of the regulatory cell cycle proteins p21, p27, p14, p16, p53, mdm2, and cyclin E in bone marrow biopsies with acute myeloid leukemia. Correlation with patients’ survival
score: 4.4018114, Pathology - Research and Practice, 2007, Zolota, Vassiliki et. al.

Molecular genetics in myelodysplastic syndromes
score: 4.4013512, Leukemia Research, 2012, Haferlach, Torsten

Molecular genetics in myelodysplastic syndromes
score: 4.4013512, Leukemia Research, 2012, Haferlach, Torsten

Absence of cyclin D1/PRAD1 point mutations in human breast cancers and parathyroid adenomas and identification of a new cyclin D1 gene polymorphism
score: 4.4005675, Cancer Letters, 1995, Hosokawa, Yoshitaka et. al.

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.
score: 4.3980366, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Mullighan, C G; Downing, J R

Targeted therapy of cancer: new roles for pathologists in identifying GISTs and other sarcomas.
score: 4.394741, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Antonescu, Cristina R

Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status
score: 4.3924708, Lung Cancer, 2010, Kalikaki, Aristea et. al.

p53 mutations in urinary bladder cancer
score: 4.390623, British Journal of Cancer, 2001, Berggren, P et. al.

Aberrant ALK Tyrosine Kinase Signaling
score: 4.3905981, The American Journal of Pathology, 2000, Ladanyi, Marc

Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34+ /CD38- cells and sensitizes them to antileukemia agents.
score: 4.3894976, International journal of cancer. Journal international du cancer, 2011, Ikezoe, Takayuki et. al.

Therapeutic advances in leukemia and myelodysplastic syndrome over the past 40 years.
score: 4.3880145, Cancer, 2008, Kantarjian, Hagop et. al.

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth
score: 4.3844939, BMC Cancer, 2009, Mita, Hiroaki et. al.

Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases.
score: 4.3829286, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Lasota, Jerzy et. al.

Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference
score: 4.3769205, Leukemia Research, 2007, Valent, Peter et. al.

Copy number profiling in von Hippel-Lindau disease renal cell carcinoma.
score: 4.3764074, Genes, chromosomes & cancer, 2011, Shuib, Salwati et. al.

The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease
score: 4.3734323, Blood Reviews, 2003, Mistry, Anita R et. al.

Mapping of the chromosome 19 q-arm glioma tumor suppressor gene using fluorescence in situ hybridization and novel microsatellite markers.
score: 4.373136, Genes, chromosomes & cancer, 2000, Smith, J S et. al.

Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.
score: 4.3724496, Molecular cancer research : MCR, 2009, Lin, Eva et. al.

Ki- ras oncogene activation in preinvasive pancreatic cancer
score: 4.3722007, Gastroenterology, 1992, Lemoine, Nicholas R. et. al.

Occurrence of the Cys611Tyr mutation and a novel Arg886Trp substitution in the RET proto-oncogene in multiple endocrine neoplasia type 2 families and sporadic medullary thyroid carcinoma cases originating from the central region of Portugal.
score: 4.3682413, Clinical endocrinology, 2006, Prazeres, Hugo João et. al.

High resolution analysis of follicular lymphoma genomes reveals somatic recurrent sites of copy-neutral loss of heterozygosity and copy number alterations that target single genes.
score: 4.3681914, Genes, chromosomes & cancer, 2010, Cheung, K-John J et. al.

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma
score: 4.3671249, Cancer Genetics and Cytogenetics, 2002, Sandberg, Avery A; Bridge, Julia A

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.
score: 4.364919, Proceedings of the National Academy of Sciences of the United States of America, 2007, Beroukhim, Rameen et. al.

Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers.
score: 4.3647078, Cancer research, 1996, Uchida, K et. al.

A Combined Cytogenetic and Molecular Approach to Diagnosis in a Case of Desmoplastic Small Round Cell Tumor with a Complex Translocation (11;22;21)
score: 4.3622648, Cancer Genetics and Cytogenetics, 1999, Roberts, Paul et. al.

Frequency and clinical correlates of JAK2 46/1 (GGCC) haplotype in primary myelofibrosis.
score: 4.3602018, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Guglielmelli, P et. al.

How to manage essential thrombocythemia.
score: 4.3569555, Leukemia, 2012, Finazzi, G

Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability
score: 4.3569219, Cancer Genetics and Cytogenetics, 2005, Fernández-Peralta, Antonia M. et. al.

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
score: 4.3564892, Cytokine and Growth Factor Reviews, 2004, Östman, Arne

The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system.
score: 4.3542835, British journal of cancer, 1998, Fox, J C et. al.

Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma
score: 4.3515432, Cancer Letters, 2007, Riquelme, Erick et. al.

Cancer therapy targeted at cellular signal transduction mechanisms: Strategies, clinical results, and unresolved issues
score: 4.3418274, European Journal of Pharmacology, 2009, Christoffersen, Thoralf et. al.

qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3 , CSF1-R , PDGFRB , MET and AXL
score: 4.3412349, BMC Molecular Biology, 2010, Fassunke, Jana et. al.

Molecular characterisation of cell line models for triple-negative breast cancers
score: 4.3409577, BMC Genomics, 2012, Grigoriadis, Anita et. al.

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors
score: 4.3372354, Cancer Genetics and Cytogenetics, 2003, Sandberg, Avery A; Bridge, Julia A

Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas.
score: 4.3344783, British journal of cancer, 1996, Shi, Y; Zou, M; Farid, N R; al-Sedairy, S T

From nodule to differentiated thyroid carcinoma: Contributions of molecular analysis in 2012
score: 4.3343989, Annales d'Endocrinologie, 2012, Albarel, Frédérique; Conte-Devolx, Bernard; Oliver, Charles

Alterations of p14ARF, p53, and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma.
score: 4.3331141, Cancer research, 2001, Nicholson, S A et. al.

Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers.
score: 4.332509, Oncogene, 2002, Zabarovsky, Eugene R; Lerman, Michael I; Minna, John D

Pharmacogenomics of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
score: 4.3317326, BBA - Reviews on Cancer, 2006, Jimeno, Antonio; Hidalgo, Manuel

Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study.
score: 4.3313197, Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 2013, André, T et. al.

Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands
score: 4.3311834, Oral Oncology, 2001, Kiyoshima, T et. al.

Somatic mutation theory, DNA repair rates, and the molecular epidemiology of p53 mutations
score: 4.3280132, Mutation Research-Reviews in Mutation Research, 1997, Holmquist, Gerald P.; Gao, Shuwei

Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice.
score: 4.3272683, The American journal of gastroenterology, 2001, Queneau, P E et. al.

Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia
score: 4.3258051, Best Practice & Research Clinical Haematology, 2010, Meijerink, Jules P.P.

The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status
score: 4.3256858, The American Journal of Pathology, 2004, West, Robert B. et. al.

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
score: 4.3253445, British journal of cancer, 2006, Gray-Schopfer, V C et. al.

Gastrointestinal stromal tumors: Pathology and prognosis at different sites
score: 4.3252512, Seminars in Diagnostic Pathology, 2006, Miettinen, Markku; Lasota, Jerzy

The Myeloproliferative Neoplasms: Insights into Molecular Pathogenesis and Changes in WHO Classification and Criteria for Diagnosis
score: 4.3226648, Hematology/Oncology Clinics of North America, 2009, Anastasi, John

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study
score: 4.3222719, BMC Cancer, 2010, Naguib, Adam et. al.

Colorectal serrated adenocarcinoma.
score: 4.3187347, Histopathology, 2007, Mäkinen, M J

CancerProView: A Graphical Image Database of Cancer-related Genes and Proteins
score: 4.3177447, Genomics, 2012, Mitsuyama, Susumu; Shimizu, Nobuyoshi

Absence of germline mutations in exons 5–9 of the p53 gene in patients with Li-Fraumeni-like (SBLA) and familial adenomatous polyposis heritable cancer syndromes
score: 4.3173428, Cancer Genetics and Cytogenetics, 1996, Moore, Stephen K. et. al.

Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability.
score: 4.3161061, International journal of cancer. Journal international du cancer, 2000, Ejima, Y; Yang, L; Sasaki, M S

Low frequency of E-cadherin alterations in familial breast cancer
score: 4.3154859, Breast Cancer Research, 2001, Salahshor, Sima et. al.

Fusion of the COL1A1 and USP6 genes in a benign bone tumor
score: 4.3139636, Cancer Genetics and Cytogenetics, 2008, Panagopoulos, Ioannis et. al.

JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer
score: 4.3134255, Cancer Cell, 2012, Britschgi, Adrian et. al.

Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors.
score: 4.3130536, Genes, chromosomes & cancer, 2011, Joosse, Simon A et. al.

DNA Copy Number Losses in Human Neoplasms
score: 4.3118023, The American Journal of Pathology, 1999, Knuutila, Sakari et. al.

Diagnosing myelodysplastic/myeloproliferative neoplasms: laboratory testing strategies to exclude other disorders.
score: 4.3099157, International journal of laboratory hematology, 2010, Hall, J; Foucar, Kathryn

Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer?
score: 4.3085171, British Journal of Cancer, 2007, Uramoto, H; Mitsudomi, T

p53 gene analysis of ovarian borderline tumors and stage I carcinomas
score: 4.3082761, Human Pathology, 1995, Kupryjanczyk, Jolanta et. al.

Common features of myeloproliferative disorders with t(8;9)(p12;q33) and CEP110–FGFR1 fusion: Report of a new case and review of the literature
score: 4.3074629, Leukemia Research, 2008, Mozziconacci, Marie-Joëlle et. al.

Mutation analysis of the p73 gene in nonastrocytic brain tumours.
score: 4.3066918, British journal of cancer, 2001, Alonso, M E et. al.

Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case.
score: 4.306213, Japanese journal of clinical oncology, 2009, Hosogi, Hisahiro et. al.

Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing
score: 4.3026913, Genome Biology, 2011, Harismendy, Olivier et. al.

Mutational status of the epidermal growth factor receptor (EGFR) gene in thymomas and thymic carcinomas
score: 4.3015475, Cancer Letters, 2007, Meister, Michael et. al.

NR4A3 rearrangement reliably distinguishes between the clinicopathologically overlapping entities myoepithelial carcinoma of soft tissue and cellular extraskeletal myxoid chondrosarcoma
score: 4.3003351, Virchows Archiv, 2012, Flucke, Uta et. al.

Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: Results from the Netherlands Cohort Study
score: 4.3000606, Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, 2008, Weijenberg, M.P. et. al.

Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer.
score: 4.2995879, Genes, chromosomes & cancer, 2000, Gemma, A et. al.

Liposarcoma: Molecular Genetics and Therapeutics
score: 4.2991388, Sarcoma, 2010, Conyers, Rachel; Young, Sophie; Thomas, David M.

Relative 8q gain predicts disease-specific survival irrespective of the TMPRSS2-ERG fusion status in diagnostic biopsies of prostate cancer.
score: 4.297445, Genes, chromosomes & cancer, 2011, Barros-Silva, João D et. al.

Loss of Heterozygosity in Squamous Cell Carcinomas of the Head and Neck Defines a Tumor Suppressor Gene Region on 11q13
score: 4.2974031, Cancer Genetics and Cytogenetics, 1998, Venugopalan, Murali et. al.

Clear cell variant of squamous cell carcinoma originating in the esophagus: report of a case with immunohistochemical and oncogenetic analyses.
score: 4.2966529, Pathology international, 2012, Imamhasan, Abdukadir et. al.

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.
score: 4.2964213, Oncogene, 2010, Wilson, C H; McIntyre, R E; Arends, M J; Adams, D J

Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.
score: 4.2940802, Genes, chromosomes & cancer, 2010, Bralten, Linda B C et. al.

Mutations in Exons 9 and 13 of KIT Gene Are Rare Events in Gastrointestinal Stromal Tumors
score: 4.2929379, The American Journal of Pathology, 2000, Lasota, Jerzy et. al.

A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene
score: 4.2854789, BMC Research Notes, 2009, Hurst, Carolyn D et. al.

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
score: 4.2853566, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Steelman, L S et. al.

Association of JC Virus T-Antigen Expression With the Methylator Phenotype in Sporadic Colorectal Cancers
score: 4.2815646, Gastroenterology, 2006, Goel, Ajay et. al.

Molecular markers in the diagnosis of prostate cancer
score: 4.2806785, Critical Reviews in Oncology and Hematology, 2007, van der Poel, H.G.

The Molecular Pathogenesis of Gastrointestinal Stromal Tumors
score: 4.2806502, Clinical Colorectal Cancer, 2006, Tarn, Chi; Godwin, Andrew K.

Allele specific Taqman-based real-time PCR assay to quantify circulating BRAF V600E mutated DNA in plasma of melanoma patients
score: 4.278118, Clinica Chimica Acta, 2010, Pinzani, Pamela et. al.

EGFR Signaling in Colorectal Carcinoma
score: 4.2762311, Pathology Research International, 2011, Krasinskas, Alyssa M.

A novel, de novo germline TP53 mutation in a rare presentation of the Li-Fraumeni syndrome in the maxilla
score: 4.2708997, Oral Oncology, 2002, Patrikidou, Anna et. al.

p53 gene mutation in N-butyl- N-(4-hydroxybutyl)nitrosamine-induced urinary bladder tumors and N-methyl- N-nitrosourea-induced colon tumors of rats
score: 4.2701821, Cancer Letters, 1997, Min, Hongzhong et. al.

Cytogenetics and the surgeon: an invaluable tool in diagnosis, prognosis and counselling of patients with solid tumours.
score: 4.2690441, The British journal of surgery, 1998, Phillips, R K; Clark, S K

JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies
score: 4.2684045, Seminars in Cell and Developmental Biology, 2008, Vainchenker, William et. al.

Tumour cells of extramammary Paget's disease do not show either p53 mutation or allelic loss at several selected loci implicated in other cancers.
score: 4.267761, British journal of cancer, 1997, Takata, M; Hatta, N; Takehara, K

Differential gene expression in melanocytic nevi with the V600E BRAF mutation.
score: 4.2646461, Genes, chromosomes & cancer, 2007, Bloethner, Sandra et. al.

CancerProView: A graphical image database of cancer-related genes and proteins
score: 4.2626912, Genomics, 2012, Mitsuyama, Susumu; Shimizu, Nobuyoshi

CancerProView: A graphical image database of cancer-related genes and proteins
score: 4.2626912, Genomics, 2012, Mitsuyama, Susumu; Shimizu, Nobuyoshi

Progress and challenges in the identification of biomarkers for EGFR and VEGFR targeting anticancer agents
score: 4.2624306, Drug Resistance Updates, 2008, Le Tourneau, Christophe; Vidal, Laura; Siu, Lillian L.

Cell multiplication
score: 4.2606741, Current Opinion in Cell Biology, 1990,

Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis
score: 4.2582189, American Journal of Obstetrics and Gynecology, 2008, Kurman, Robert J. et. al.

Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait.
score: 4.2569585, Cancer research, 2002, Halford, Sarah et. al.

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
score: 4.256232, British Journal of Cancer, 2006, Gray-Schopfer, V C et. al.

1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
score: 4.2550505, Oncogene, 2012, Mackintosh, C et. al.

Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer.
score: 4.2544569, Oncogene, 2003, Konishi, Hiroyuki et. al.

Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors
score: 4.254111, The American Journal of Pathology, 2000, Gimm, Oliver et. al.

Absence of FGFR3 mutations in urinary bladder tumours of rats and mice treated with N-butyl-N-(-4-hydroxybutyl)nitrosamine.
score: 4.2505865, Molecular carcinogenesis, 2005, Dunois-Lardé, Claire et. al.

Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera
score: 4.2488938, Cancer Cell, 2008, Wernig, Gerlinde et. al.

Expression of DOG1, PDGFRA, and p16 in Gastrointestinal Stromal Tumors
score: 4.2486456, Gut and Liver, 2011, Jung, Sung Hee et. al.

Integrative genomic approaches to understanding cancer
score: 4.2452958, BBA - General Subjects, 2009, Hahn, William C. et. al.

Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines
score: 4.2446083, PLoS ONE, 2009, Gandhi, Jeet et. al.

Inhibition of nonsense-mediated messenger RNA decay in clinical samples facilitates detection of human MSH2 mutations with an in vivo fusion protein assay and conventional techniques.
score: 4.2432321, Cancer research, 1997, Andreutti-Zaugg, C; Scott, R J; Iggo, R

Acceleration of chromosomal instability by loss of BRCA1 expression and p53 abnormality in sporadic breast cancers
score: 4.2423147, Cancer Letters, 2000, Miyoshi, Yasuo et. al.

Acute promyelocytic leukemia: a model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia.
score: 4.2402173, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002, Grimwade, D; Lo Coco, F

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.
score: 4.2391136, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Reckzeh, K et. al.

Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples
score: 4.238699, Experimental and Molecular Pathology, 2012, Didelot, Audrey et. al.

Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples
score: 4.238699, Experimental and Molecular Pathology, 2012, Didelot, Audrey et. al.

Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples
score: 4.238699, Experimental and Molecular Pathology, 2012, Didelot, Audrey et. al.

The role of FLT3 in haematopoietic malignancies.
score: 4.2385282, Nature reviews. Cancer, 2003, Stirewalt, Derek L; Radich, Jerald P

Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.
score: 4.2376621, British journal of cancer, 1997, Hatta, Y; Takeuchi, S; Yokota, J; Koeffler, H P

Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer
score: 4.2372438, BMC Cancer, 2012, Kim, Mi-Jung et. al.

High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.
score: 4.2268732, Cancer, 2012, Choy, Edwin et. al.

Genetic susceptibility to cancer
score: 4.2239343, Annals of the ICRP, 1998,

Mutation analysis of the p73 gene in nonastrocytic brain tumours
score: 4.220997, British Journal of Cancer, 2001, Alonso, M E et. al.

Genetic alterations and oxidative metabolism in sporadic colorectal tumors from a Spanish community.
score: 4.2188146, Molecular carcinogenesis, 1997, Oliva, M R et. al.

Molecular insights into gastrointestinal neuroendocrine tumours: importance and recent advances
score: 4.2174514, Digestive and Liver Disease, 2002, Corleto, V.D.; Delle Fave, G.; Jensen, R.T.

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc Min/+ mice via activation of Wnt and ERK1/2 MAPK pathways
score: 4.2170535, Oncogene, 2010, Wilson, CH; McIntyre, RE; Arends, MJ; Adams, DJ

Somatic alterations of the SMAD-2 gene in human colorectal cancers.
score: 4.2161488, British Journal of Cancer, 1998, Takagi, Y. et. al.

Analytical methods for inferring functional effects of single base pair substitutions in human cancers
score: 4.215883, Human Genetics, 2009, Lee, William; Yue, Peng; Zhang, Zemin

On being metachromatic: mystique and misunderstanding in mastocytosis.
score: 4.2131927, American journal of hematology, 2009, Gotlib, Jason

The myelodysplastic/myeloproliferative neoplasms: myeloproliferative diseases with dysplastic features.
score: 4.211533, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Orazi, A; Germing, U

A Tumor Sorting Protocol that Enables Enrichment of Pancreatic Adenocarcinoma Cells and Facilitation of Genetic Analyses
score: 4.2109854, The Journal of Molecular Diagnostics, 2009, Boyd, Zachary S. et. al.

Cytogenomics of cancers: From chromosome to sequence
score: 4.2074857, Molecular Oncology, 2010, Bernheim, Alain

Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats.
score: 4.2036466, Molecular carcinogenesis, 2001, Suzui, M et. al.

PDGF Receptors as Targets in Tumor Treatment
score: 4.2030052, Advances in Cancer Research, 2007, Östman, Arne; Heldin, Carl‐Henrik

PDGF Receptors as Targets in Tumor Treatment
score: 4.2030052, Advances in Cancer Research, 2007, Östman, Arne; Heldin, Carl‐Henrik

E-Cadherin ( CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients
score: 4.2018935, European Journal of Cancer, 2004, Oliveira, Carla et. al.

Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies.
score: 4.2010848, Cancer research, 2006, Schittenhelm, Marcus M et. al.

Delving into somatic variation in sporadic melanoma.
score: 4.2005907, Pigment cell & melanoma research, 2012, Walia, Vijay; Mu, Euphemia W; Lin, Jimmy C; Samuels, Yardena

Absence of BRAF mutation in pediatric and adolescent germ cell tumors indicate biological differences to adult tumors.
score: 4.199353, Pediatric blood & cancer, 2012, Masqué-Soler, Neus et. al.

Is it important to decipher the heterogeneity of “normal karyotype AML”?
score: 4.1977386, Best Practice & Research Clinical Haematology, 2008, Nimer, Stephen D.

Numbers of colony-forming progenitors in patients with systemic mastocytosis: potential diagnostic implications and comparison with myeloproliferative disorders.
score: 4.1959474, European journal of clinical investigation, 2003, Jordan, J-H et. al.

Prodromal myeloproliferative neoplasms: the 2008 WHO classification.
score: 4.1918045, American journal of hematology, 2010, Kvasnicka, Hans Michael; Thiele, Juergen

Absence of BRAF and HRAS mutations in eruptive Spitz naevi.
score: 4.1917976, The British journal of dermatology, 2011, Gantner, S et. al.

A microdissection approach to detect molecular markers during progression of prostate cancer.
score: 4.1870936, British Journal of Cancer, 1995, Berthon, P. et. al.

Mutational activation of the c-K- ras gene in human pancreatic carcinoma
score: 4.1867468, Bailliere's Clinical Gastroenterology, 1990, Shibata, Darryl; Capella, Gabriel; Perucho, Manuel

BCR-JAK2 fusion as a result of a translocation (9;22)(p24;q11.2) in a patient with CML-like myeloproliferative disease
score: 4.1849056, Molecular Cytogenetics, 2012, Elnaggar, Mohamed M et. al.

Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.
score: 4.1842214, Human molecular genetics, 1993, Paul, P et. al.

Mutation screening of the CDKN2A promoter in melanoma families.
score: 4.1809618, Genes, chromosomes & cancer, 2000, Harland, M et. al.

Polymerase chain reaction-based methods for the detection of mutations in oncogenes and tumor suppressor genes
score: 4.1763527, Human Pathology, 1994, Loda, Massimo

Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas
score: 4.1735784, Gene, 2005, Gunduz, Mehmet et. al.

Ewing's Sarcoma and Primitive Neuroectodermal Family of Tumors
score: 4.1733348, Hematology/Oncology Clinics of North America, 2005, Carvajal, Richard; Meyers, Paul

Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors.
score: 4.1726748, Oncogene, 2009, John, T; Liu, G; Tsao, M-S

Frequent allelic imbalance but infrequent microsatellite instability in gastric lymphoma.
score: 4.1722336, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1999, Hoeve, M A et. al.

Mutational analysis of the kinase domain of MYLK2 gene in common human cancers
score: 4.1713472, Pathology - Research and Practice, 2006, Soung, Young Hwa et. al.

Abstracts
score: 4.1701214, Experimental Hematology, 2007,

Frequency and application of the hot spot BRAF gene mutation (p.V600E) in the diagnostic strategy for Hereditary Nonpolyposis Colorectal Cancer
score: 4.1683052, Cancer Detection and Prevention, 2007, Kadiyska, Tanya K. et. al.

c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis.
score: 4.1672526, British Journal of Cancer, 1991, Bell, S. M. et. al.

Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy
score: 4.166584, BMC Medical Genomics, 2012, Tuna, Musaffe et. al.

Pathogenetic Role of JAK2 V617F Mutation in Chronic Myeloproliferative Disorders
score: 4.1653684, Journal of the Chinese Medical Association, 2007, Hsu, Hui-Chi

Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics.
score: 4.1627506, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Einspahr, Janine G et. al.

The XRCC1 codon 399 Gln allele is associated with adenine to guanine p53 mutations in non-small cell lung cancer
score: 4.1616945, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2003, Casse, Celine; Hu, Ying Chuan; Ahrendt, Steven A.

p53 alterations in atypical alveolar hyperplasia of the human lung
score: 4.1599896, Human Pathology, 1998, Slebos, Robbert J.C et. al.

Ten years of the cytogenetics of soft tissue tumors
score: 4.159089, Cancer Genetics and Cytogenetics, 1997, Dal Cin, Paola; Van den Berghe, Herman

Janus Kinase Mutations
score: 4.1579273, Seminars in Oncology, 2009, Levine, Ross L.

ras mutations in 2-acetylaminofluorene-induced lung and liver tumors from C3H/HeJ and (C3H x A/J)F1 mice.
score: 4.1538616, Cancer research, 1993, Wang, Y; Wang, Y; Stoner, G; You, M

Cytogenetic and molecular aspects of Philadelphia negative chronic myeloproliferative disorders: Clinical implications
score: 4.153605, Cancer Letters, 2007, Panani, Anna D.

Chemical-specific alterations in ras, p53, and β-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years
score: 4.1529037, Toxicology and Applied Pharmacology, 2003, Hong, H.L et. al.

Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non–mast cell hematopoietic neoplasms
score: 4.1523609, The Journal of Allergy and Clinical Immunology, 2004, Valent, Peter et. al.

Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non–mast cell hematopoietic neoplasms
score: 4.1523609, The Journal of Allergy and Clinical Immunology, 2004, Valent, Peter et. al.

Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma
score: 4.1508876, Oncogene, 2010, Cooke, Susanna L et. al.

Clinical experience with gefitinib: An update
score: 4.1482871, Critical Reviews in Oncology and Hematology, 2006, Cappuzzo, Federico et. al.

Hereditary and Sporadic Papillary Renal Carcinomas with c- met Mutations Share a Distinct Morphological Phenotype
score: 4.1478862, The American Journal of Pathology, 1999, Lubensky, Irina A. et. al.

Cytologic and molecular diagnosis of thyroid cancers: is it time for routine reflex testing?
score: 4.1467682, Cancer cytopathology, 2012, Hassell, Lewis A; Gillies, Elizabeth M; Dunn, S Terence

Constitutional aneuploidy and cancer predisposition.
score: 4.1452965, Human molecular genetics, 2009, Ganmore, Ithamar; Smooha, Gil; Izraeli, Shai

JAK2 the future: therapeutic strategies for JAK-dependent malignancies
score: 4.1450828, Trends in Pharmacological Sciences, 2012, LaFave, Lindsay M.; Levine, Ross L.

JAK2 the future: therapeutic strategies for JAK-dependent malignancies
score: 4.1450828, Trends in Pharmacological Sciences, 2012, LaFave, Lindsay M.; Levine, Ross L.

Potential role of a navigator gene NAV3 in colorectal cancer
score: 4.1445691, British Journal of Cancer, 2011, Carlsson, E et. al.

The Human ROX Gene: Genomic Structure and Mutation Analysis in Human Breast Tumors
score: 4.1380434, Genomics, 1998, Nigro, Cristiana Lo et. al.

KIT D816V–associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities
score: 4.1365923, The Journal of Allergy and Clinical Immunology, 2007, Maric, Irina et. al.

PTEN mutations do not cause nuclear β-catenin accumulation in endometrial carcinomas
score: 4.135285, Human Pathology, 2004, Wappenschmidt, B. et. al.

Assessment of a fully automated high-throughput DNA extraction method from formalin-fixed, paraffin-embedded tissue forKRAS, andBRAFsomatic mutation analysis
score: 4.1350397, Experimental and Molecular Pathology, 2013, van Eijk, Ronald et. al.

Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis.
score: 4.1338645, The Journal of pathology, 2007, Karsai, S et. al.

Clinical features of molecular pathology of solid tumours in childhood
score: 4.1320989, Lancet Oncology, 2005, Messahel, Boo et. al.

NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Disease-Specific Methods and Strategies for Monitoring Relapse Following Allogeneic Stem Cell Transplantation. Part II: Chronic Leukemias, Myeloproliferative Neoplasms, and Lymphoid Malignancies
score: 4.1315187, Biology of Blood and Marrow Transplantation, 2010, Kröger, Nicolaus et. al.

Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Associated With Colorectal Tumor Progression
score: 4.1309591, Gastroenterology, 2009, Ohta, Miki et. al.

The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models.
score: 4.1270355, British journal of cancer, 2009, Faur, N et. al.

Allele loss from large regions of chromosome 17 is common only in certain histological subtypes of ovarian carcinomas.
score: 4.1235764, British Journal of Cancer, 1996, Papp, J. et. al.

EXT-Mutation Analysis and Loss of Heterozygosity in Sporadic and Hereditary Osteochondromas and Secondary Chondrosarcomas
score: 4.123452, The American Journal of Human Genetics, 1999, Bovée, Judith V.M.G. et. al.

Genomic instability in 1p and human malignancies.
score: 4.120522, Genes, chromosomes & cancer, 1996, Schwab, M; Praml, C; Amler, L C

Molecular pathogenesis of pancreatic cancer
score: 4.1171943, Best Practice & Research Clinical Gastroenterology, 2006, Maitra, Anirban; Kern, Scott E.; Hruban, Ralph H.

The genetics of pancreatic cancer
score: 4.1157872, The American Journal of Surgery, 2003, Cowgill, Sarah M; Muscarella, Peter

Chromosomal Aberrations in Solid Tumors
score: 4.1150469, Progress in Molecular Biology and Translational Science, 2010, Chinnaiyan, Arul M.; Palanisamy, Nallasivam

Gene expression changes in normal haematopoietic cells
score: 4.1140317, Best Practice & Research Clinical Haematology, 2009, Lionberger, Jack M.; Stirewalt, Derek L.

Patterns of K-ras codon 12 and 13 mutations found in pancreatic adenocarcinoma of 30 Chinese patients by microdissection, PCR and direct sequencing.
score: 4.1124849, Journal of gastroenterology and hepatology, 2005, Wei, Shuanzeng et. al.

New approaches to understanding p53 gene tumor mutation spectra
score: 4.1056328, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999, Hollstein, Monica et. al.

Integrative approach for prioritizing cancer genes in sporadic colon cancer.
score: 4.1055373, Genes, chromosomes & cancer, 2009, Reid, James F et. al.

Ras mutation cooperates with β -catenin activation to drive bladder tumourigenesis
score: 4.1030447, Cell Death & Disease, 2011, Ahmad, I et. al.

Bone marrow biopsies of patients with hematopoietic and lymphoid disorders – epidemiology, chromosomal aberrations and molecular pathology
score: 4.1020961, Pathology - Research and Practice, 2012, Hehne, Sophie et. al.

Bone marrow biopsies of patients with hematopoietic and lymphoid disorders – epidemiology, chromosomal aberrations and molecular pathology
score: 4.1020961, Pathology - Research and Practice, 2012, Hehne, Sophie et. al.

The second international congress on myeloproliferative and myelodysplastic syndromes
score: 4.1012202, Leukemia Research, 2004, Silver, R.T et. al.

Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression
score: 4.1008293, Leukemia Research, 2003, Stirewalt, D.L. et. al.

beta-Catenin nuclear accumulation in head and neck mucoepidermoid carcinoma: its role in cyclin D1 overexpression and tumor progression.
score: 4.1004307, Head & neck, 2007, Shiratsuchi, Hideki et. al.

Molecular prognostics in colorectal cancer
score: 4.1000697, Surgical Oncology, 2003, Kahlenberg, Morton S. et. al.

Primary lung adenocarcinoma occurring in a PTEN related syndrome (Cowden's disease): Routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L
score: 4.0998785, Lung Cancer, 2013, Boespflug, Amélie et. al.

Can Systems Biology Understand Pathway Activation? Gene Expression Signatures as Surrogate Markers for Understanding the Complexity of Pathway Activation
score: 4.0992427, Current Genomics, 2008, Itadani, Hiraku; Mizuarai, Shinji; Kotani, Hidehito

JAK2 GGCC haplotype in MPL mutated myeloproliferative neoplasms.
score: 4.0984135, American journal of hematology, 2012, Pietra, Daniela et. al.

Chromosome 5 allelic losses are early events in tumours of the papilla of Vater and occur at sites similar to those of gastric cancer.
score: 4.0961203, British Journal of Cancer, 1998, Achille, A. et. al.

p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia.
score: 4.0960039, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Ng, K P et. al.

Experimental oral carcinoma of the tongue and buccal mucosa: possible biologic markers linked to cancers at two anatomic sites
score: 4.0922656, Oral Oncology, 2000, Schwartz, J.L. et. al.

Analysis of mutations in the K- ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene
score: 4.0902629, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997, Smith, Beverly A et. al.

A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
score: 4.0900581, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2007, Denning, Karen M et. al.

Clinically useful prognostic factors in acute myeloid leukemia
score: 4.087343, Critical Reviews in Oncology and Hematology, 2008, Ferrara, Felicetto; Palmieri, Salvatore; Leoni, Franco

Familial Adenomatous Polyposis-Associated Desmoids Display Significantly More Genetic Changes than Sporadic Desmoids
score: 4.0842241, PLoS ONE, 2011, Robanus-Maandag, Els et. al.

Genomic alterations (LOH, MI) on chromosome 17q21-23 and prognosis of sporadic colorectal cancer.
score: 4.0840271, International journal of cancer. Journal international du cancer, 2000, Berney, C R; Fisher, R J; Yang, J; Russell, P J; Crowe, P J

Pharmacologic rationale for early G-CSF prophylaxis in cancer patients and role of pharmacogenetics in treatment optimization
score: 4.0837324, Critical Reviews in Oncology and Hematology, 2009, Crea, Francesco et. al.

Pathogenetic and biologic significance of TP14 ARF alterations in nonsmall cell lung carcinoma
score: 4.0815855, Cancer Genetics and Cytogenetics, 2003, Park, Myung-Jae et. al.

Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: case report with immunohistochemical and mutational analysis.
score: 4.0813538, Pathology international, 2006, Han, Bo et. al.

Thyroid carcinoma-associated genetic mutations also occur in thyroid lymphomas.
score: 4.0812271, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Aggarwal, Nidhi et. al.

Immunotherapy Targets in Pediatric Cancer
score: 4.0793527, Frontiers in Oncology, 2011, Orentas, Rimas J.; Lee, Daniel W.; Mackall, Crystal

Molecular Profiling of Bladder Tumors Based on the Detection of FGFR3 and TP53 Mutations
score: 4.0789895, The Journal of Urology, 2006, Lamy, A. et. al.

K-ras mutation in focal proliferative lesions of human pancreas.
score: 4.078385, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998, Terhune, P G; Phifer, D M; Tosteson, T D; Longnecker, D S

KIT Mutations in Mastocytosis and Their Potential as Therapeutic Targets
score: 4.0764673, Immunology and Allergy Clinics of North America, 2006, Gotlib, Jason

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations
score: 4.0761818, Experimental and Molecular Pathology, 2008, Segditsas, Stefania et. al.

Mutated and wild-type p53 expression and HPV integration in proliferative verrucous leukoplakia and oral squamous cell carcinoma
score: 4.0740336, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 1997, Gopalakrishnan, Rajaram et. al.

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
score: 4.0722932, Nature, 2012, Prahallad, Anirudh et. al.

Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy
score: 4.0714485, Pathology - Research and Practice, 2006, Diniz, Gulden et. al.

Paternal Age Effect Mutations and Selfish Spermatogonial Selection: Causes and Consequences for Human Disease
score: 4.0711821, The American Journal of Human Genetics, 2012, Goriely, Anne; Wilkie, Andrew O.M.

The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors
score: 4.0695819, Experimental Hematology, 2008, Lin, Tzu-Yin et. al.

Mutations of the human E-cadherin (CDH1) gene.
score: 4.0684149, Human mutation, 1998, Berx, G; Becker, K F; Höfler, H; van Roy, F

Inverse PCR-based RFLP scanning identifies low-level mutation signatures in colon cells and tumors.
score: 4.0664579, Cancer research, 2004, Liu, Wei-Hua et. al.

Novel Mutations in CEBPA in Korean Patients with Acute Myeloid Leukemia with a Normal Karyotype
score: 4.0660204, Annals of Laboratory Medicine, 2012, Kim, Sollip et. al.

Detection and molecular cytogenetic characterization of a novel ring chromosome in a histological variant of Ewing sarcoma
score: 4.0658528, Cancer Genetics and Cytogenetics, 2007, Szuhai, Károly et. al.

Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): Detection of FIP1L1/PDGFRα, classification by WHO criteria, and response to therapy with imatinib
score: 4.0649318, Leukemia Research, 2006, Florian, Stefan et. al.

Aberrant methylation of the negative regulators RASSFIA, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukaemia.
score: 4.0625868, British journal of haematology, 2005, Johan, M F; Bowen, D T; Frew, M E; Goodeve, A C; Reilly, J T

Pyrosequencing data analysis software: a useful tool for EGFR, KRAS, and BRAF mutation analysis
score: 4.05926, Diagnostic Pathology, 2012, Shen, Shanxiang; Qin, Dahui

Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
score: 4.0592325, Cancer research, 1999, Takaku, K et. al.

Tumor suppressor loss in pituitary tumors.
score: 4.0570848, Brain pathology (Zurich, Switzerland), 2001, Alexander, J M

Two Li-Fraumeni syndrome families with novel germline p53 mutations: loss of the wild-type p53 allele in only 50% of tumours.
score: 4.056916, British Journal of Cancer, 1998, Sedlacek, Z. et. al.

Tumor heterogeneity: Causes and consequences
score: 4.0567035, BBA - Reviews on Cancer, 2010, Marusyk, Andriy; Polyak, Kornelia

Changing phenotype of gastrointestinal stromal tumours under imatinib mesylate treatment: a potential diagnostic pitfall.
score: 4.0555721, Histopathology, 2005, Pauwels, P et. al.

A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes
score: 4.0548064, BMC Cancer, 2010, Fumagalli, Debora et. al.

Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
score: 4.0547973, The Journal of Experimental Medicine, 2006, Radomska, Hanna S. et. al.

Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis
score: 4.0544168, The Journal of Allergy and Clinical Immunology, 2004, Escribano, Luis et. al.

Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis
score: 4.0544168, The Journal of Allergy and Clinical Immunology, 2004, Escribano, Luis et. al.

JAK2 V617F mutation is a rare event in juvenile myelomonocytic leukemia.
score: 4.053866, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Zecca, M et. al.

Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction.
score: 4.0538302, British Journal of Cancer, 1994, Cawkwell, L.; Lewis, F. A.; Quirke, P.

Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma.
score: 4.0532927, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2009, Flavin, Richard J et. al.

Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment
score: 4.0531686, BMC Medicine, 2012, Brana, Irene; Siu, Lillian L

Mutation-associated fusion cancer genes in solid tumors.
score: 4.0504003, Molecular cancer therapeutics, 2009, Kaye, Frederic J

Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.
score: 4.0492193, Cancer research, 2000, Piao, Z et. al.

Recent advances of novel targeted therapy in non-small cell lung cancer
score: 4.0491609, Journal of Hematology and Oncology, 2009, Katzel, Jed A; Fanucchi, Michael P; Li, Zujun

Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias
score: 4.0486273, Cancer Genetics and Cytogenetics, 2006, Yoshimoto, Maisa et. al.

Low somatic K- ras mutation frequency in colorectal cancer diagnosed under the age of 45 years
score: 4.0469646, European Journal of Cancer, 2006, Alsop, Kathryn et. al.

Abstracts
score: 4.0420242, Experimental Hematology, 2008,

The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.
score: 4.0418498, Molecular cancer therapeutics, 2011, Floris, Giuseppe et. al.

Functional analysis of p53 tumor suppressor in yeast
score: 4.0409382, Differentiation, 2005, Šmardová, Jana; Šmarda, Jan; Koptíková, Jana

Molecular Diagnosis of Ewing Family Tumors
score: 4.0390176, The Journal of Molecular Diagnostics, 2007, Barr, Frederic G.; Womer, Richard B.

Heterozygous tandem duplication within the PTCH1 gene results in nevoid basal cell carcinoma syndrome.
score: 4.0384335, American journal of medical genetics. Part A, 2012, Kosaki, Rika et. al.

Hedgehog–Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer
score: 4.0360802, Cancer Letters, 2004, Ruiz i Altaba, Ariel; Stecca, Barbara; Sánchez, Pilar

The CDKN2A/CDKN2B/CDK4/CCND1 pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis: an analysis of 104 tumors.
score: 4.034175, Genes, chromosomes & cancer, 2011, Louis-Brennetot, Caroline et. al.

HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression
score: 4.0303409, BMC Cancer, 2007, Dierssen, Jan Willem F et. al.

Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer
score: 4.0266795, Nucleic Acids Research, 2008, Xi, Liqiang et. al.

Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia.
score: 4.0260712, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2003, Fülöp, Z; Csernus, B; Tímár, B; Szepesi, A; Matolcsy, A

Use of twins in search for tumor suppressor genes.
score: 4.0246299, Environmental and molecular mutagenesis, 1997, Försti, A; Söderberg, M; Hemminki, K

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
score: 4.024183, Oncogene, 2010, Nogueira, Cristina et. al.

Dissecting the molecular pathways of (testicular) germ cell tumour pathogenesis; from initiation to treatment-resistance.
score: 4.0206493, International journal of andrology, 2011, Looijenga, L H J et. al.

Ki- ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: Relation to gross tumor morphology
score: 4.0197258, Gastroenterology, 1995, Ohashi, Kazuo et. al.

Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9q31.
score: 4.0186888, Oncogene, 1999, Simoneau, M et. al.

Application of growth factor stimulants improves cytogenetic analysis of chronic myeloproliferative disorder patients without alteration to cell lineage or clonality
score: 4.0183743, Cancer Genetics and Cytogenetics, 2007, Vaughan, B.R.; Scott, M.A.; Nacheva, E.P.; Howard, J.D.

KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.
score: 4.0174942, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Agell, Laia et. al.

Glioma-derived mutations in IDH: From mechanism to potential therapy
score: 4.0171482, Biochemical and Biophysical Research Communications, 2010, Fu, Yuejun et. al.

Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survival
score: 4.0162882, Cancer Genetics and Cytogenetics, 2005, Marsit, Carmen J. et. al.

Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis.
score: 4.0147302, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011, Sotlar, Karl et. al.

Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-Targeted Therapy
score: 4.0116225, Advances in Hematology, 2011, Fathi, Amir T.; Abdel-Wahab, Omar

High-content analysis of cancer genome DNA alterations
score: 4.0104819, Current Opinion in Genetics & Development, 2008, Degenhardt, Yan Y et. al.

Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients.
score: 4.0094336, British journal of cancer, 2011, Scartozzi, M et. al.

Aberrant signal transduction pathways in myeloproliferative neoplasms.
score: 4.0094044, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Kota, J; Caceres, N; Constantinescu, S N

Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients.
score: 4.0079578, Oncogene, 2002, Perren, Aurel et. al.

Infrequent Ki-ras and an absence of p53 mutations in hepatocellular carcinomas induced by a choline deficient l-amino acid defined diet in rats
score: 4.0066528, Cancer Letters, 1996, Tsujiuchi, Toshifumi et. al.

Identification of altered MicroRNA expression patterns in synovial sarcoma.
score: 4.006002, Genes, chromosomes & cancer, 2011, Hisaoka, Masanori et. al.

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
score: 4.0053827, International journal of experimental pathology, 2009, Luo, Feijun et. al.

Epigenomics of cancer – emerging new concepts
score: 4.0032219, Biochimie, 2012, Hassler, Melanie R.; Egger, Gerda

Diagnostic value of detecting fusion proteins derived from chromosome translocations in acute leukaemia
score: 4.0014394, Best Practice & Research Clinical Haematology, 2003, Lo-Coco, Francesco et. al.

Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.
score: 4.0008808, Carcinogenesis, 1997, Hong, H L et. al.

Phenotypic variability within the JAK2 V617F-positive MPD: Roles of progenitor cell and neutrophil allele burdens
score: 4.0004846, Experimental Hematology, 2008, Moliterno, Alison R. et. al.

EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples
score: 4.0003059, Journal of Clinical Pathology, 2012, Ellison, Gillian et. al.

5q- myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics.
score: 3.9987665, Oncogene, 2009, Eisenmann, K M et. al.

Somatic alterations of the SMAD-2 gene in human colorectal cancers.
score: 3.9979068, British journal of cancer, 1998, Takagi, Y et. al.

A census of predicted mutational epitopes suitable for immunologic cancer control
score: 3.9959264, Human Immunology, 2010, Warren, René L.; Holt, Robert A.

A Novel TP53 Germ-Line Mutation Identified in a Girl with a Primitive Neuroectodermal Tumor and Her Father
score: 3.9942319, Cancer Genetics and Cytogenetics, 1998, Orellana, Carmen et. al.

Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors
score: 3.9937942, BMC Genomics, 2006, Balko, Justin M et. al.

Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient.
score: 3.991452, Genes, chromosomes & cancer, 2007, Pecciarini, Lorenza et. al.

Therapy-related leukemia: clinical characteristics and analysis of new molecular risk factors in 96 adult patients.
score: 3.9908239, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Rund, D et. al.

Heterozygous Germline Mutations in the CBL Tumor-Suppressor Gene Cause a Noonan Syndrome-like Phenotype
score: 3.9861772, The American Journal of Human Genetics, 2010, Martinelli, Simone et. al.

Mutation Detection by Real-Time PCR: A Simple, Robust and Highly Selective Method
score: 3.9852528, PLoS ONE, 2009, Morlan, John; Baker, Joffre; Sinicropi, Dominick

Comparative genomic hybridization and BUB1B mutation analyses in childhood cancers associated with mosaic variegated aneuploidy syndrome
score: 3.9823609, Cancer Letters, 2006, Hanks, Sandra et. al.

Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers.
score: 3.9809594, Oncogene, 1998, Konishi, H et. al.

A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.
score: 3.9804671, Genes, chromosomes & cancer, 2007, Poland, Kathryn S et. al.

STAT3 negatively regulates thyroid tumorigenesis.
score: 3.9797509, Proceedings of the National Academy of Sciences of the United States of America, 2012, Couto, Joana Pinto et. al.

Opposing Effects of Ras on p53
score: 3.9788474, Cell, 2000, Ries, Stefan et. al.

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
score: 3.9762218, Genes, chromosomes & cancer, 2010, Gaedcke, Jochen et. al.

Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma.
score: 3.9760746, Journal of immunology (Baltimore, Md. : 1950), 2002, Sato, Yuriko et. al.

Distinct pattern of PCR–SSCP analysis of p53 mutations in human astrocytomas
score: 3.9754802, Cancer Letters, 1999, Thangnipon, Wipawan et. al.

Are there two sides to colorectal cancer?
score: 3.9751586, International journal of cancer. Journal international du cancer, 2002, Iacopetta, Barry

Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines.
score: 3.9751219, Genes, chromosomes & cancer, 2001, Wiest, J; Clark, A M; Dai, W

Absence of p53 gene mutations in primary nasopharyngeal carcinomas.
score: 3.9737725, Cancer research, 1992, Spruck, C H et. al.

ERBBs in the gastrointestinal tract: Recent progress and new perspectives
score: 3.9734771, Experimental Cell Research, 2009, Fiske, William H.; Threadgill, David; Coffey, Robert J.

Mutation of tumor suppressor gene p53 is frequently found in vulvar carcinoma cells
score: 3.9734749, American Journal of Obstetrics and Gynecology, 1995, Hietanen, Sakari H. et. al.

Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion positive and fusion negative prostate cancer
score: 3.9719677, The American Journal of Pathology, 2012, Krohn, Antje et. al.

Microsatellite instability at tetranucleotide repeats in skin and bladder cancer.
score: 3.9716547, Oncogene, 2002, Danaee, Hadi et. al.

Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene.
score: 3.9716159, Oncogene, 2000, Kanamori, M et. al.

Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation.
score: 3.9694399, British Journal of Cancer, 1998, Schmitt, C. A. et. al.

Association of EWS-FLI1 Type 1 Fusion with Lower Proliferative Rate in Ewing's Sarcoma
score: 3.9692896, The American Journal of Pathology, 2000, de Alava, Enrique et. al.

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.
score: 3.9685565, Genes, chromosomes & cancer, 2000, Smits, R et. al.

Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma.
score: 3.9676012, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Pallarés, Judit et. al.

Cytogenetics of pediatric acute myeloid leukemia.
score: 3.9671659, European journal of haematology, 2009, Manola, Kalliopi N

Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions
score: 3.9659249, Molecular and Cellular Endocrinology, 2010, Handkiewicz-Junak, Daria et. al.

Acute myeloid leukemia (AML) having evolved from essential thrombocythemia (ET): distinctive chromosome abnormalities in patients treated with pipobroman or hydroxyurea.
score: 3.9651429, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002, Bernasconi, P et. al.

EGFR exon 20 insertion mutation in Japanese lung cancer
score: 3.9634888, Lung Cancer, 2007, Sasaki, Hidefumi et. al.

Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors.
score: 3.9628476, Cancer research, 2001, Ortiz, B H et. al.

The role of microsatellite instability in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix
score: 3.9602697, Gynecologic Oncology, 2003, Wong, Yick-Fu et. al.

Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium.
score: 3.9602696, Oncogene, 2012, Archibald, K M et. al.

PTEN: Life as a Tumor Suppressor
score: 3.9562667, Experimental Cell Research, 2001, Simpson, Laura; Parsons, Ramon

Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell lung cancer
score: 3.9529827, Lung Cancer, 2005, Rosell, Rafael et. al.

Identification of Ki23819, a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase.
score: 3.9493135, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Komeno, Y et. al.

c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis.
score: 3.9490106, British journal of cancer, 1991, Bell, S M et. al.

Activation of the GLI Oncogene through Fusion with the β-Actin Gene ( ACTB) in a Group of Distinctive Pericytic Neoplasms
score: 3.9486982, The American Journal of Pathology, 2004, Dahlén, Anna et. al.

Molecular Profiling of Endometrial Malignancies
score: 3.947292, Obstetrics and Gynecology International, 2010, Samarnthai, Norasate; Hall, Kevin; Yeh, I-Tien

Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers.
score: 3.9462562, Oncogene, 2007, Wu, Y-H et. al.

A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.
score: 3.942835, Cancer research, 2008, Martins, Ana Sofia et. al.

Analysis of EGFR, KRAS and P53 mutations in lung cancer using cells in the curette lavage fluid obtained by bronchoscopy
score: 3.9420108, Lung Cancer, 2012, Yamaguchi, Fumihiro et. al.

Analysis of EGFR, KRAS and P53 mutations in lung cancer using cells in the curette lavage fluid obtained by bronchoscopy
score: 3.9420108, Lung Cancer, 2012, Yamaguchi, Fumihiro et. al.

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.
score: 3.941474, Proceedings of the National Academy of Sciences of the United States of America, 2008, Garzon, Ramiro et. al.

Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers.
score: 3.9381378, British Journal of Cancer, 1997, Collins, N.; Wooster, R.; Stratton, M. R.

Alterations of Fas (APO-1/CD95) gene in transitional cell carcinomas of urinary bladder.
score: 3.9374548, Cancer research, 1999, Lee, S H et. al.

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.
score: 3.9336674, Environmental Health Perspectives, 1991, Capella, G; Cronauer-Mitra, S; Pienado, M A; Perucho, M

Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1
score: 3.9333486, Gene, 2008, Zhao, Yan et. al.

LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability.
score: 3.9332829, Carcinogenesis, 2011, Melcher, Ralph et. al.

Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors.
score: 3.9300855, Oncogene, 1999, Khanna, M et. al.

Telomerase regulation in hematological cancers: A matter of stemness?
score: 3.9300486, BBA - Molecular Basis of Disease, 2009, Deville, Laure; Hillion, Josette; Ségal-Bendirdjian, Evelyne

Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas
score: 3.9290937, BMC Cancer, 2012, Gonzaga, Isabela Martins et. al.

Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers.
score: 3.9244145, International journal of cancer. Journal international du cancer, 2003, Yu, Mei Y et. al.

Frequent allele loss on 9p21-22 defines a smallest common region in the vicinity of the CDKN2 gene in sporadic breast cancer.
score: 3.9233192, Genes, chromosomes & cancer, 1996, An, H X et. al.

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
score: 3.9231749, Cancer Cell, 2002, Kelly, Louise M et. al.

The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
score: 3.9215007, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Mikesch, J-H et. al.

Improving outcomes for high-risk ALL: translating new discoveries into clinical care.
score: 3.9189379, Pediatric blood & cancer, 2011, Hunger, Stephen P et. al.

Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers.
score: 3.9169738, Cancer research, 2005, Samowitz, Wade S et. al.

Acute myeloid leukaemia
score: 3.916619, The Lancet, 2006, Estey, Elihu; Döhner, Hartmut

FLT3 Inhibitors
score: 3.9161433, European Journal of Cancer, 2004, Brown, P; Small, D

Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.
score: 3.9149272, British journal of cancer, 2005, Máximo, V et. al.

Analysis of the P53, RB/D13S25, and P16 Tumor Suppressor Genes in Marginal Zone B-cell Lymphoma
score: 3.914137, Cancer Genetics and Cytogenetics, 2000, Dierlamm, J et. al.

Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease.
score: 3.9119252, Oncogene, 2002, Scheijen, Blanca; Griffin, James D

K- ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors
score: 3.9101488, Cancer Letters, 1996, Calvert, Richard J. et. al.

Autocrine PDGF stimulation in malignancies
score: 3.9080612, Upsala Journal of Medical Sciences, 2012, Heldin, Carl-Henrik

Quantitative Determination of JAK2 V617F by TaqMan
score: 3.9079884, The Journal of Molecular Diagnostics, 2007, Hammond, Emma et. al.

Current aspects of the pathology of soft tissue sarcomas
score: 3.9078891, Seminars in Radiation Oncology, 1999, Fisher, Cyril

Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
score: 3.9061952, Urologic Oncology: Seminars and Original Investigations, 2010, Goebell, Peter J.; Knowles, Margaret A.

p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan
score: 3.9054797, British Journal of Cancer, 2004, Hsieh, L-L et. al.

Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.
score: 3.9053884, Oncogene, 2004, Sakamoto, Naoto et. al.

Allele loss from large regions of chromosome 17 is common only in certain histological subtypes of ovarian carcinomas.
score: 3.9053343, British journal of cancer, 1996, Papp, J et. al.

Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication.
score: 3.9048735, British journal of haematology, 2008, Mead, Adam J et. al.

Intra- and Inter-Tumor Heterogeneity of BRAF V600E Mutations in Primary and Metastatic Melanoma
score: 3.9048518, PLoS ONE, 2012, Yancovitz, Molly et. al.

Multiple Neuroendocrine Tumors of the Pancreas in von Hippel-Lindau Disease Patients
score: 3.9032202, The American Journal of Pathology, 1998, Lubensky, Irina A. et. al.

Interferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms.
score: 3.9019461, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Kiladjian, J-J; Chomienne, C; Fenaux, P

Venous thromboembolism in patients with essential thrombocythemia and polycythemia vera.
score: 3.9015481, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Reikvam, H; Tiu, R V

The myelodysplastic syndrome(s): a perspective and review highlighting current controversies
score: 3.9011672, Leukemia Research, 2003, Steensma, David P; Tefferi, Ayalew

Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature.
score: 3.9011647, Genes, chromosomes & cancer, 2008, Coffey, Jerome et. al.

Absence of rearrangements in the BRCA2 gene in human cancers.
score: 3.9002855, British journal of cancer, 2001, Chin, S F; Wang, Q; Puisieux, A; Caldas, C

Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma
score: 3.8999254, Pathology - Research and Practice, 2012, Benedix, Frank et. al.

Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma
score: 3.8999254, Pathology - Research and Practice, 2012, Benedix, Frank et. al.

Oncogenic mutations in extramammary Paget's disease and their clinical relevance.
score: 3.8986259, International journal of cancer. Journal international du cancer, 2013, Kang, Zhihua et. al.

Characterization of Dysplastic Aberrant Crypt Foci in the Rat Colon Induced by 2-Amino-1-Methyl-6-Phenylimidazo[4,5- b]Pyridine
score: 3.8958847, The American Journal of Pathology, 2003, Ochiai, Masako et. al.

K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
score: 3.8945708, British journal of cancer, 1994, Breivik, J et. al.

K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
score: 3.8945708, British Journal of Cancer, 1994, Breivik, J. et. al.

Janus kinase 2 mutations in Philadelphia negative chronic myeloproliferative disorders: Clinical implications
score: 3.8915852, Cancer Letters, 2009, Panani, Anna D.

Applications of Microarray Technology to Acute Myelogenous Leukemia
score: 3.891459, Cancer Informatics, 2008, Goswami, Rashmi S. et. al.

No evidence for involvement of SDHD in neuroblastoma pathogenesis
score: 3.8914235, BMC Cancer, 2004, De Preter, Katleen et. al.

Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa.
score: 3.8911327, Cancer, 2001, Beghini, A et. al.

COSMIC 2005
score: 3.8903141, British Journal of Cancer, 2006, Forbes, S et. al.

Mutations of K-ras but not p53 genes in biliary duct and pancreatic duct carcinomas induced in hamsters by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis(2-oxopropyl)amine
score: 3.8901193, Cancer Letters, 1997, Majima, Toshimitsu et. al.

Molecular defects in the pathogenesis of pituitary tumours
score: 3.8869119, Frontiers in Neuroendocrinology, 2003, Levy, Andy; Lightman, Stafford

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
score: 3.8866342, Cancer Cell, 2009, Vasudevan, Krishna M. et. al.

Targeting sarcomas: therapeutic targets and their rational
score: 3.8846919, Seminars in Diagnostic Pathology, 2008, Ordóñez, José Luis et. al.

Analysis of differential BRAF(V600E) mutational status in multifocal papillary thyroid carcinoma: evidence of independent clonal origin in distinct tumor foci.
score: 3.8833083, Cancer, 2006, Park, So Yeon et. al.

Origins and molecular pathology of ovarian cancer.
score: 3.8832254, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2005, Bell, Debra A

Trying to compose the puzzle with all the pieces: epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.
score: 3.8822706, Journal of cellular physiology, 2005, Di Maio, Massimo et. al.

Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.
score: 3.8821582, Genes, chromosomes & cancer, 2003, Hohenstein, Peter et. al.

The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia
score: 3.880936, Blood Reviews, 2012, Moorman, Anthony V.

Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium.
score: 3.8808202, Journal of cellular physiology, 2007, Keller, Jeffrey W et. al.

Comparative analysis of germline and somatic microlesion mutational spectra in 17 human tumor suppressor genes.
score: 3.8805698, Human mutation, 2011, Ivanov, Dobril et. al.

Minimal residual disease diagnostics in myeloid malignancies in the post transplant period.
score: 3.8798886, Bone marrow transplantation, 2008, Bacher, U et. al.

Emerging ethnic differences in lung cancer therapy.
score: 3.8798553, British journal of cancer, 2008, Sekine, I; Yamamoto, N; Nishio, K; Saijo, N

Ki-ras codon 12 point and P53 mutations: a molecular examination of the main tumor, liver, portal vein, peripheral arterial blood and para-aortic lymph node in pancreatic cancer
score: 3.8798498, The American Journal of Gastroenterology, 2000, Yamaguchi, Koji et. al.

Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia.
score: 3.8796863, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Valencia, A et. al.

JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations.
score: 3.8796041, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Pardanani, A et. al.

Loss of Dpc4 Expression in Colonic Adenocarcinomas Correlates with the Presence of Metastatic Disease
score: 3.8787681, The American Journal of Pathology, 2000, Maitra, Anirban et. al.

Chromosome 5 allelic losses are early events in tumours of the papilla of Vater and occur at sites similar to those of gastric cancer.
score: 3.8778783, British journal of cancer, 1998, Achille, A et. al.

BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes.
score: 3.8775099, Oncogene, 2005, Domingo, Enric et. al.

Frequent and characteristic K- ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon
score: 3.8756117, Gastroenterology, 1995, Yamashita, Naoyuki et. al.

Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal.
score: 3.8737412, Leukemia, 2008, Vannucchi, A M et. al.

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
score: 3.8704736, Proceedings of the National Academy of Sciences of the United States of America, 2012, Ohashi, Kadoaki et. al.

Controlling Destiny through Chemistry: Small-Molecule Regulators of Cell Fate
score: 3.8696268, ACS Chemical Biology, 2009, Firestone, Ari J.; Chen, James K.

Targeted next-generation sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure.
score: 3.8695269, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Grossmann, V et. al.

Sacrococcygeal chordomas in patients with tuberous sclerosis complex show somatic loss of TSC1 or TSC2.
score: 3.8687476, Genes, chromosomes & cancer, 2004, Lee-Jones, Lisa et. al.

Molecular targets and biological modifiers in gastric cancer
score: 3.8671042, Seminars in Diagnostic Pathology, 2008, Carneiro, Fátima et. al.

KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling.
score: 3.8660792, Molecular cancer research : MCR, 2012, Appleman, Victoria A et. al.

Clonal evolution of acute leukemia genomes.
score: 3.8658651, Oncogene, 2012, Jan, M; Majeti, R

A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis
score: 3.8656896, Disease Models & Mechanisms, 2011, Leacock, Stefanie W. et. al.

High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi.
score: 3.8654429, The Journal of investigative dermatology, 2006, Ichii-Nakato, Nami et. al.

Chronic myeloid leukemia from basics to bedside.
score: 3.8633254, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1999, Thijsen, S; Schuurhuis, G; van Oostveen, J; Ossenkoppele, G

Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD.
score: 3.8603406, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Lu, Y et. al.

Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.
score: 3.8596734, British Journal of Cancer, 1992, Eccles, D. M. et. al.

Von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens
score: 3.8586035, Human Pathology, 1996, Zhuang, Zhengping et. al.

Gastrointestinal stromal tumors: Differential diagnosis
score: 3.8537459, Seminars in Diagnostic Pathology, 2006, Dow, Nancy et. al.

Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer
score: 3.8523758, Critical Reviews in Oncology and Hematology, 2010, Stewart, David J.

A subset of human gliomas shows over-expression of KIT without its amplification
score: 3.8489006, Gene, 2012, Saini, Masum; Jha, Ajaya Nand; Abrari, Andleeb; Ali, Sher

Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: molecular classification and treatment options.
score: 3.8478728, British journal of haematology, 2008, Niemeyer, Charlotte Marie; Kratz, Christian Peter

Epigenomics of cancer – emerging new concepts
score: 3.8462903, Biochimie, 2012, Hassler, Melanie R.; Egger, Gerda

Epigenomics of cancer – emerging new concepts
score: 3.8462903, Biochimie, 2012, Hassler, Melanie R.; Egger, Gerda

Epigenomics of cancer – emerging new concepts
score: 3.8462903, Biochimie, 2012, Hassler, Melanie R.; Egger, Gerda

Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer
score: 3.8457462, Cancer Letters, 2008, Frattini, M. et. al.

Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.
score: 3.8452948, British journal of cancer, 2012, Troiani, T et. al.

Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples
score: 3.8451636, BMC Medical Genomics, 2012, de la Blétière, Diane Raingeard et. al.

ABL1 rearrangements in T-cell acute lymphoblastic leukemia.
score: 3.8438456, Genes, chromosomes & cancer, 2010, Hagemeijer, Anne; Graux, Carlos

The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans
score: 3.8432999, Cancer Cell, 2006, Carrasco, Daniel R. et. al.

Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.
score: 3.841115, Molecular cancer therapeutics, 2010, Levy, Ran; Grafi-Cohen, Meital; Kraiem, Zaki; Kloog, Yoel

Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia.
score: 3.841012, Leukemia, 2012, Damm, F et. al.

Clear-cell sarcoma of the soft tissue--a rare diagnosis with a fatal outcome.
score: 3.8396184, European journal of cancer care, 2012, Ipach, I; Mittag, F; Kopp, H-G; Kunze, B; Wolf, P; Kluba, T

UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer
score: 3.8387938, Journal of Photochemistry & Photobiology, B: Biology, 2001, de Gruijl, Frank R; van Kranen, Henk J; Mullenders, Leon H.F

Two Li-Fraumeni syndrome families with novel germline p53 mutations: loss of the wild-type p53 allele in only 50% of tumours.
score: 3.838674, British journal of cancer, 1998, Sedlacek, Z et. al.

Abstracts of the 46th Annual Scientific Meeting of the British Society for Haematology incorporating the Netherlands and British Haemostasis and Thrombosis Societies, 3-5 April 2006, Edinburgh, United Kingdom.
score: 3.8377391, British journal of haematology, 2006,

JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials.
score: 3.8371291, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Pardanani, A

Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma.
score: 3.8369396, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2005, Patel, Rajiv M et. al.

Deactylase inhibition in myeloproliferative neoplasms
score: 3.8359171, Investigational New Drugs, 2010, Mithraprabhu, Sridurga et. al.

Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction.
score: 3.8355881, British journal of cancer, 1994, Cawkwell, L; Lewis, F A; Quirke, P

Lung Cancer: Are we up to the Challenge?
score: 3.8354157, Current Genomics, 2010, Esposito, Luca et. al.

Parathyroid tumor suppressor on 1p: analysis of the p18 cyclin-dependent kinase inhibitor gene as a candidate.
score: 3.8350992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1997, Tahara, H et. al.

Deletions of the Short Arm of Chromosome 3 in Solid Tumors and the Search for Suppressor Genes
score: 3.8348634, Advances in Cancer Research, 1997, Kok, Klaas; Naylor, Susan L.; Buys, Charles H.C.M.

Review of erlotinib in the treatment of advanced non-small cell lung cancer
score: 3.8346556, Biologics : Targets & Therapy, 2007, Ganjoo, Kristen N; Wakelee, Heather

Colorectal cancer and genetic alterations in the Wnt pathway.
score: 3.8333744, Oncogene, 2006, Segditsas, S; Tomlinson, I

Activation of c-Ki-ras in human gastrointestinal dysplasias determined by direct sequencing of polymerase chain reaction products.
score: 3.8307558, Cancer research, 1990, Meltzer, S J et. al.

Resistance of Philadelphia-chromosome positive leukemia towards the kinase inhibitor imatinib (STI571, Glivec): a targeted oncoprotein strikes back.
score: 3.829944, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2003, von Bubnoff, N; Peschel, C; Duyster, J

APC and the three-hit hypothesis.
score: 3.8272234, Oncogene, 2009, Segditsas, S et. al.

KIT mutations confer a distinct gene expression signature in core binding factor leukaemia.
score: 3.8253221, British journal of haematology, 2010, Lück, Sonja C et. al.

High frequency of copy-neutral LOH in MUTYH-associated polyposis carcinomas.
score: 3.8183289, The Journal of pathology, 2008, Middeldorp, A et. al.

Overexpression of the Hepatocyte Growth Factor (HGF) Receptor (Met) and Presence of a Truncated and Activated Intracellular HGF Receptor Fragment in Locally Aggressive/Malignant Human Musculoskeletal Tumors
score: 3.8173295, The American Journal of Pathology, 2000, Wallenius, Ville et. al.

Absence of rearrangements in the BRCA2 gene in human cancers
score: 3.8145907, British Journal of Cancer, 2001, Chin, S-F; Wang, Q; Puisieux, A; Caldas, C

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer
score: 3.8144796, Lung Cancer, 2012, Ueno, Tsuyoshi et. al.

Overcoming acquired resistance to kinase inhibition: The cases of EGFR, ALK and BRAF
score: 3.8142395, Bioorganic & Medicinal Chemistry Letters, 2013, Giroux, Simon

Genetics and epigenetics of renal cell cancer
score: 3.8137996, BBA - Reviews on Cancer, 2008, Baldewijns, Marcella M.L. et. al.

FES kinases are required for oncogenic FLT3 signaling.
score: 3.8136864, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Voisset, E et. al.

A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias
score: 3.8117383, Leukemia Research, 2009, Kreil, Sebastian et. al.

Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation
score: 3.8112989, Human Pathology, 2007, Guo, Hua et. al.

Allelic loss of 11q13 as detected by MEN1-FISH is not associated with mutation of the MEN1 gene in lymphoid neoplasms.
score: 3.8111934, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1999, Thieblemont, C et. al.

Index to volume 52.
score: 3.8091968, Cancer research, 1992,

p53 mutations in breast cancer.
score: 3.8089949, Cancer research, 1992, Coles, C et. al.

RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia.
score: 3.8083618, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Wiemels, J L et. al.

C-KIT expression in ductal carcinoma in situ of the breast: co-expression with HER-2/neu
score: 3.808047, Human Pathology, 2006, Diallo, Raihanatou et. al.

Minimally invasive biomarkers for detection and staging of colorectal cancer
score: 3.8049379, Cancer Letters, 2007, Booth, Ronald A.

Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type.
score: 3.8036684, Cancer, 1993, Finkelstein, S D; Sayegh, R; Christensen, S; Swalsky, P A

Genetics of disease
score: 3.8026582, Current Opinion in Genetics & Development, 1997,

Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis
score: 3.8025088, Leukemia Research, 2012, Koren-Michowitz, Maya et. al.

Genome-wide arrays in routine diagnostics of hematological malignancies.
score: 3.8022337, Human mutation, 2012, Simons, Annet et. al.

Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer
score: 3.8013592, BMC Cancer, 2012, Kristensen, Lasse Sommer et. al.

Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry.
score: 3.7983475, British Journal of Cancer, 1998, Marsh, K. L.; Varley, J. M.

Chromosomal aberrations in thyroid follicular-cell neoplasia: in the search of novel oncogenes and tumour suppressor genes
score: 3.7956064, Molecular and Cellular Endocrinology, 2010, Zitzelsberger, Horst; Thomas, Gerry; Unger, Kristian

TP53 mutations and polymorphisms in primary myelofibrosis.
score: 3.7929118, American journal of hematology, 2011, Raza, Sania et. al.

p53 Mutation and MDM2 amplification in inflammatory myofibroblastic tumours.
score: 3.7911799, Histopathology, 2003, Yamamoto, H et. al.

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis
score: 3.7900588, Cancer Cell, 2010, Bennecke, Moritz et. al.

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 ( PTPN11) mutations
score: 3.7900027, Cancer Cell, 2005, Mohi, M. Golam et. al.

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
score: 3.7883787, Nature, 2008, Zheng, Hongwu et. al.

Antitumor activity of sorafenib in FLT3-driven leukemic cells.
score: 3.7879802, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Auclair, D et. al.

Domain landscapes of somatic mutations in cancer
score: 3.787978, BMC Genomics, 2012, Nehrt, Nathan L et. al.

Absence of Common Somatic Alterations in Genes on 1p and 19q in Oligodendrogliomas
score: 3.7877638, PLoS ONE, 2011, Bralten, Linda B. et. al.

Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia.
score: 3.7877513, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Chan, Andrew T et. al.

Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes
score: 3.7865776, BMC Cancer, 2013, Pentheroudakis, George et. al.

Colon tumor mutations and epigenetic changes associated with genetic polymorphism: Insight into disease pathways
score: 3.7808228, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2009, Slattery, Martha L. et. al.

Analysis of the tumor suppressor gene p53 in xeroderma pigmentosum fibroblasts
score: 3.7805702, Cancer Letters, 1994, Lavu, Sukadev; Srivastava, Meera; Srivastava, Shiv K.

Tyrosine kinase inhibitor insensitivity of non-cycling CD34+ human acute myeloid leukaemia cells with FMS-like tyrosine kinase 3 mutations.
score: 3.7802511, British journal of haematology, 2011, Alvares, Caroline L et. al.

The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia
score: 3.7791773, Leukemia Research, 2008, Kasper, Stefan et. al.

Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients
score: 3.7791723, British Journal of Cancer, 2011, Scartozzi, M et. al.

Lung cancer in never smokers – A review
score: 3.7772983, European Journal of Cancer, 2012, Couraud, Sébastien et. al.

Lung cancer in never smokers – A review
score: 3.7772983, European Journal of Cancer, 2012, Couraud, Sébastien et. al.

Lung cancer in never smokers – A review
score: 3.7772983, European Journal of Cancer, 2012, Couraud, Sébastien et. al.

BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas. MPT Collaborators, St George's Hospital Collaborators.
score: 3.7768491, British journal of cancer, 1999, Gill, S et. al.

Newly established Askin tumor cell line and overexpression of focal adhesion kinase in Ewing sarcoma family of tumors cell lines
score: 3.7759964, Cancer Genetics and Cytogenetics, 2003, Moritake, Hiroshi et. al.

Role of proto-oncogene activation in carcinogenesis.
score: 3.7743716, Environmental Health Perspectives, 1992, Anderson, M W; Reynolds, S H; You, M; Maronpot, R M

Restricted 12p Amplification and RAS Mutation in Human Germ Cell Tumors of the Adult Testis
score: 3.7734152, The American Journal of Pathology, 2000, Roelofs, Helene et. al.

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
score: 3.7733661, Molecular Cancer, 2011, Minde, David P et. al.

Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis.
score: 3.7726997, Cancer research, 2003, Aldred, Micheala A et. al.

Advances in Ewing's sarcoma research: where are we now and what lies ahead?
score: 3.7719915, Cancer research, 2009, Ordóñez, José Luis et. al.

Single-Nucleotide Polymorphism Array Karyotyping in Clinical Practice: Where, When, and How?
score: 3.7701929, Seminars in Oncology, 2012, Sato-Otsubo, Aiko; Sanada, Masashi; Ogawa, Seishi

Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodysplastic syndromes.
score: 3.7690981, Cancer research, 2004, Linnartz, Bjoern; Anglmayer, Roswitha; Zanssen, Stefanie

Prognostic significance of K- ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers
score: 3.7657022, European Journal of Cancer, 2003, Grossi, F et. al.

Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas.
score: 3.7643402, Cancer research, 1993, Waber, P G; Chen, J; Nisen, P D

Deletion analysis of the adenomatous polyposis coli and PTCH gene loci in patients with sporadic and nevoid basal cell carcinoma syndrome-associated medulloblastoma.
score: 3.7636708, Cancer, 1999, Vortmeyer, A O et. al.

Genetic and expressional alterations of CHD genes in gastric and colorectal cancers.
score: 3.7624673, Histopathology, 2011, Kim, Min Sung et. al.

Absence of genetic abnormalities in fibroadenomas of the breast determined at p53 gene mutations and microsatellite alterations.
score: 3.7624599, Cancer research, 2001, Franco, N; Picard, S F; Mege, F; Arnould, L; Lizard-Nacol, S

Genotypic and phenotypic progression in endometrial tumorigenesis: determining when defects in DNA mismatch repair and KRAS2 occur.
score: 3.7623637, Genes, chromosomes & cancer, 2001, Cohn, D E et. al.

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols.
score: 3.761936, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Zuurbier, L et. al.

Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells.
score: 3.7605252, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2006, Turner, S D; Alexander, D R

Lack of BCL10 mutations in multiple myeloma and plasma cell leukemia.
score: 3.7604581, Genes, chromosomes & cancer, 2001, Shih, L Y et. al.

Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations
score: 3.7594555, Molecular Cytogenetics, 2011, Maric, Irena et. al.

Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays.
score: 3.7592752, Cancer science, 2008, Suzuki, Makoto et. al.

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma.
score: 3.7590847, British journal of cancer, 2004, Soufir, N et. al.

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined Apc Min and KRAS V 12 mutations
score: 3.756728, Molecular Cancer, 2010, Nandan, Mandayam O et. al.

Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer.
score: 3.7556491, Cancer science, 2008, Mano, Hiroyuki

WHO bone marrow features and European clinical, molecular, and pathological (ECMP) criteria for the diagnosis of myeloproliferative disorders
score: 3.7549207, Leukemia Research, 2007, Michiels, Jan Jacques et. al.

Pathological and molecular analysis of sporadic hepatic angiomyolipoma
score: 3.7545619, Human Pathology, 2006, Xu, Ai-Min et. al.

Genetic and epigenetic alterations in primary colorectal cancers and related lymph node and liver metastases.
score: 3.7544706, Cancer, 2013, Miranda, Elena et. al.

Repression of Gadd45alpha by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation.
score: 3.7540775, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Perugini, M et. al.

Alterations of APC, c- met, and p53 genes in tumor tissue and serum of patients with gastric cancers
score: 3.7529474, Journal of Surgical Research, 2004, Wang, Jaw-Yuan et. al.

Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation.
score: 3.7511979, British journal of cancer, 1998, Schmitt, C A et. al.

Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss.
score: 3.7482585, International journal of cancer. Journal international du cancer, 2008, Riemenschneider, Markus J et. al.

Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.
score: 3.7482352, The Journal of investigative dermatology, 2002, McGregor, Jane M et. al.

Fusions of the SYT and SSX genes in synovial sarcoma.
score: 3.7480063, Oncogene, 2001, Ladanyi, M

A novel N-ras mutation in malignant melanoma is associated with excellent prognosis.
score: 3.7462133, Cancer research, 2001, Demunter, A et. al.

A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas
score: 3.7434267, Journal of Experimental & Clinical Cancer Research : CR, 2012, Jancik, Sylwia et. al.

Molecular alterations during insulinoma tumorigenesis
score: 3.7432789, BBA - Reviews on Cancer, 2007, Jonkers, Y.M.H.; Ramaekers, F.C.S.; Speel, E.J.M.

Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms.
score: 3.7432191, Annals of the New York Academy of Sciences, 2010, Tartaglia, Marco; Gelb, Bruce D

Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection.
score: 3.7399861, Cancer research, 1992, Fujita, M; Inoue, M; Tanizawa, O; Iwamoto, S; Enomoto, T

miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death
score: 3.739712, Molecular Cancer, 2012, Bryant, Adam et. al.

p53 mutations in head and neck cancer: new data and evaluation of mutational spectra.
score: 3.7395575, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Olshan, A F; Weissler, M C; Pei, H; Conway, K

Investigation of minimal residual disease in childhood and adult acute lymphoblastic leukaemia by molecular analysis.
score: 3.7376895, British journal of haematology, 1999, Foroni, L; Harrison, C J; Hoffbrand, A V; Potter, M N

Gene amplification in human gliomas.
score: 3.7364285, Glia, 1995, Collins, V P

The biology of Kit in disease and the application of pharmacogenetics
score: 3.732818, The Journal of Allergy and Clinical Immunology, 2004, Cem Akin, ; Metcalfe, Dean D

Systematic genomic screen for tyrosine kinase mutations in CLL.
score: 3.7300966, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Brown, J R et. al.

Myelodysplastic syndromes: lost between two states?
score: 3.7285961, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Acquaviva, C; Gelsi-Boyer, V; Birnbaum, D

Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor.
score: 3.7277836, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2001, Tse, K F; Novelli, E; Civin, C I; Bohmer, F D; Small, D

Glioma cells showing IDH1 mutation cannot be propagated in standard cell culture conditions.
score: 3.7258497, British journal of cancer, 2011, Piaskowski, S et. al.

Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene.
score: 3.7241946, Cancer research, 1994, Cerutti, P; Hussain, P; Pourzand, C; Aguilar, F

Medullary thyroid carcinoma (MTC) andRETproto-oncogene: Mutation spectrum in the familial cases and a meta-analysis of studies on the sporadic form
score: 3.7239125, Mutation Research-Reviews in Mutation Research, 2013, Figlioli, Gisella et. al.

KRAS mutation is present in a small subset of primary urinary bladder adenocarcinomas.
score: 3.7214148, Histopathology, 2012, Alexander, Riley E et. al.

Idiopathic Myelofibrosis
score: 3.720956, Seminars in Hematology, 2005, Barosi, Giovanni; Hoffman, Ronald

Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers.
score: 3.7198958, British journal of cancer, 1997, Collins, N; Wooster, R; Stratton, M R

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms
score: 3.7195874, Human Molecular Genetics, 2008, Pymar, Louis S. et. al.

Frequent microsatellite instability in non-Hodgkin lymphomas irresponsive to chemotherapy
score: 3.7186006, Leukemia Research, 2008, Miyashita, Kaname et. al.

Historical perspectives on myelodysplastic syndromes
score: 3.7182816, Leukemia Research, 2012, Steensma, David P.

Historical perspectives on myelodysplastic syndromes
score: 3.7182816, Leukemia Research, 2012, Steensma, David P.

BsaXI/RFLP analysis of initial or selectively reamplified PCR product is unreliable in detecting the V617F mutation in JAK2.
score: 3.7144215, International journal of laboratory hematology, 2011, Shepard, G C; Lawson, H L; Hawkins, G A; Owen, J

Can a familial gastrointestinal tumour syndrome be allelic with Waardenburg syndrome?
score: 3.7133085, Clinical genetics, 2011, Vilain, R E et. al.

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis.
score: 3.7120143, Disease models & mechanisms, 2012, Leacock, Stefanie W et. al.

Molecular genetic alterations in carcinoma ex-pleomorphic adenoma: a putative progression model?
score: 3.7115696, Genes, chromosomes & cancer, 2000, El-Naggar, A K et. al.

Combined analysis of p53 and RB pathways in epithelial ovarian cancer
score: 3.7095231, Human Pathology, 2001, Hashiguchi, Yasunori et. al.

A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy.
score: 3.7091507, The Journal of pathology, 2008, Nakai, N et. al.

Comments on the 2001 WHO proposal for the classification of haematopoietic neoplasms
score: 3.7061428, Best Practice & Research Clinical Haematology, 2003, Paietta, Elisabeth

KRAS mutations predict response to EGFR inhibitors
score: 3.7061028, Current Opinion in Pharmacology, 2008, Raponi, Mitch; Winkler, Hans; Dracopoli, Nicholas C

Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors.
score: 3.7052987, International journal of cancer. Journal international du cancer, 2003, Chen, Hui et. al.

Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia.
score: 3.7036136, Genes, chromosomes & cancer, 2002, Olipitz, Werner et. al.

JAK2 V617F-Dependent Upregulation of PU.1 Expression in the Peripheral Blood of Myeloproliferative Neoplasm Patients
score: 3.7026218, PLoS ONE, 2011, Irino, Tamotsu et. al.

Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic features.
score: 3.7024425, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Wang, S A et. al.

The Role of the Adenomatous Polyposis Coli (Apc) Gene in Human Cancers
score: 3.7024414, Advances in Cancer Research, 1993, Nakamura, Yusuke

The Genetics of Neuroendocrine Tumors
score: 3.7016941, Seminars in Oncology, 2013, Öberg, Kjell

Genome-wide scan identifies a copy number variable region at 3q26 that regulates PPM1L in APC mutation-negative familial colorectal cancer patients.
score: 3.7009571, Genes, chromosomes & cancer, 2010, Thean, L F; Loi, C; Ho, K S; Koh, P K; Eu, K W; Cheah, P Y

Increased risk of non-small cell lung cancer and frequency of somatic TP53 gene mutations in Pro72 carriers of TP53 Arg72Pro polymorphism
score: 3.7002255, Lung Cancer, 2006, Szymanowska, Amelia et. al.

Somatic mutations of the KEAP1 gene in common solid cancers.
score: 3.6993623, Histopathology, 2012, Yoo, Nam Jin et. al.

Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia
score: 3.6992514, Leukemia Research, 1997, Blau, Orit et. al.

ALK translocation and crizotinib in non-small cell lung cancer: An evolving paradigm in oncology drug development
score: 3.6971784, European Journal of Cancer, 2012, Scagliotti, Giorgio et. al.

Somatic p16 INK4a loss accelerates melanomagenesis
score: 3.6964455, Oncogene, 2010, Monahan, K B et. al.

Aberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular Carcinoma
score: 3.6958774, The American Journal of Pathology, 2003, Yang, Bin et. al.

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
score: 3.6950703, British Journal of Cancer, 1998, Suwa, H. et. al.

Three germline mutations in the TP53 gene.
score: 3.6950475, Human mutation, 1997, Cornelis, R S et. al.

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.
score: 3.6941074, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Djordjevic, Bojana et. al.

CGH analysis of secondary genetic changes in Ewing tumors:
score: 3.6926356, Cancer Genetics and Cytogenetics, 2001, Brisset, Sophie et. al.

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2.
score: 3.6925847, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Purandare, A V et. al.

Developmental pathways in breast cancer and breast tumor-initiating cells: Therapeutic implications
score: 3.6917577, Cancer Letters, 2012, Izrailit, Julia; Reedijk, Michael

Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours.
score: 3.6896028, British journal of cancer, 2004, Dong, Z; Pang, Jc-S; Ng, M H; Poon, W S; Zhou, L; Ng, H-K

Why Does My Patient Have Thrombocytosis?
score: 3.688954, Hematology/Oncology Clinics of North America, 2012, Sulai, Nanna H.; Tefferi, Ayalew

p53 mutation and expression in lymphoma.
score: 3.6876298, British Journal of Cancer, 1995, Adamson, D. J. et. al.

An acquired G-CSF receptor mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia.
score: 3.6867836, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Germeshausen, M et. al.

Ki-ras codon 12 point and P53 mutations: a molecular examination of the main tumor, liver, portal vein, peripheral arterial blood and para-aortic lymph node in pancreatic cancer.
score: 3.6845703, The American journal of gastroenterology, 2000, Yamaguchi, K et. al.

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis
score: 3.6838694, Cancer Cell, 2010, Bennecke, Moritz et. al.

Genetic pathways to glioblastoma: a population-based study.
score: 3.6832165, Cancer research, 2004, Ohgaki, Hiroko et. al.

p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study.
score: 3.6779244, British Journal of Cancer, 1997, Buttitta, F. et. al.

A substantial proportion of microsatellite-unstable colon tumors carry TP53 mutations while not showing chromosomal instability.
score: 3.6775917, Genes, chromosomes & cancer, 2005, Westra, Jantine L et. al.

Trisomy 8 in alveolar soft part sarcoma
score: 3.6774723, Cancer Genetics and Cytogenetics, 1995, Craver, Randall D. et. al.

Update on familial cancer syndromes and the skin
score: 3.6769628, Journal of the American Academy of Dermatology, 2000, Tsao, Hensin

Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma
score: 3.6754669, Human Pathology, 1998, Fogt, Franz et. al.

Catalogue, cause, complexity and cure; the many uses of cancer genome sequence
score: 3.6754569, Current Opinion in Genetics & Development, 2010, Wooster, Richard; Bachman, Kurtis E

Inactivating mutations of caspase-8 gene in colorectal carcinomas
score: 3.6746788, Gastroenterology, 2003, Kim, Hong Sug et. al.

Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis
score: 3.6729366, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2008, Buchmann, Albrecht et. al.

Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors
score: 3.6706137, BMC Medical Genetics, 2010, Merkelbach-Bruse, Sabine et. al.

TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma.
score: 3.6700822, Journal of cellular physiology, 2006, Russo, Antonio et. al.

Frequent ATRX , CIC , FUBP1 and IDH1 mutations refine the classification of malignant gliomas
score: 3.6699166, Oncotarget, 2012, Jiao, Yuchen et. al.

Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours
score: 3.6698249, British Journal of Cancer, 2007, Carén, H; Fransson, S; Ejeskär, K; Kogner, P; Martinsson, T

Mutational analysis of caspase 1, 4, and 5 genes in common human cancers
score: 3.6691995, Human Pathology, 2008, Soung, Young Hwa et. al.

Life expectancy and prognostic factors in the classic BCR/ABL-negative myeloproliferative disorders.
score: 3.6676654, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Cervantes, F; Passamonti, F; Barosi, G

Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance.
score: 3.667378, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Grossmann, V et. al.

Germline and somatic mutations of the INK4a-ARF gene in a xeroderma pigmentosum group C patient.
score: 3.6671788, The Journal of investigative dermatology, 2002, Soufir, N et. al.

Incidence of loss of heterozygosity at p53 and BRCA1 loci in serous surface carcinoma
score: 3.6648298, Human Pathology, 1999, Quezado, Martha M et. al.

Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults
score: 3.6634449, The American Journal of Human Genetics, 2003, Zhou, Xiao-Ping et. al.

FMS mutations in patients following cytotoxic therapy for lymphoma
score: 3.6625192, Leukemia Research, 1995, Baker, Andrew et. al.

Ovarian Tumorigenesis
score: 3.6615252, The American Journal of Pathology, 2004, Shih, Ie-Ming; Kurman, Robert J.

Implications of p53 alterations and anti-p53 antibody response in head and neck squamous cell carcinomas
score: 3.6606599, Oral Oncology, 1998, Lavieille, J.-P. et. al.

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma
score: 3.6602113, Pharmacology and Therapeutics, 2012, Kelleher, Fergal C. et. al.

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma
score: 3.6602113, Pharmacology and Therapeutics, 2012, Kelleher, Fergal C. et. al.

Clonality analysis of different histological components in combined small cell and non—small cell carcinoma of the lung
score: 3.6592746, Human Pathology, 2003, Murase, Takayuki et. al.

CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.
score: 3.6570735, Genes, chromosomes & cancer, 2006, Kim, Young-Ho et. al.

Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A.
score: 3.6552579, Human mutation, 2010, McKenzie, Heather A et. al.

Tubulocystic Carcinoma, Mucinous Tubular and Spindle Cell Carcinoma, and Other Recently Described Rare Renal Tumors
score: 3.6548305, Clinics in Laboratory Medicine, 2005, MacLennan, Gregory T.; Bostwick, David G.

The RTK/RAS/BRAF/PI3K Pathways in Melanoma: Biology, Small Molecule Inhibitors, and Potential Applications
score: 3.6532542, Seminars in Oncology, 2007, Haluska, Frank et. al.

Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.
score: 3.652052, Molecular and cellular biology, 2008, McKenna, Elizabeth S et. al.

Mammalian gene studies
score: 3.6509518, Current Opinion in Biotechnology, 1993,

Germ-line ATM gene alterations are associated with susceptibility to sporadic T-cell acute lymphoblastic leukemia in children.
score: 3.6489325, Genes, chromosomes & cancer, 2004, Liberzon, Ella et. al.

Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer.
score: 3.6489119, Mutagenesis, 2012, Naccarati, A et. al.

Therapeutic modulation of k-ras signaling in colorectal cancer
score: 3.647954, Drug Discovery Today, 2010, Krens, Lisanne L. et. al.

MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells.
score: 3.6478424, Oncogene, 2000, Tanaka, M et. al.

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors.
score: 3.6477757, Nature genetics, 2002, Al-Tassan, Nada et. al.

Increased CD177 (PRV1) expression in thalassaemia and the underlying erythropoietic activity.
score: 3.6475028, British journal of haematology, 2008, Zoi, Katerina et. al.

Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.
score: 3.6468928, British journal of cancer, 2010, Baba, Y et. al.

Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K- ras point mutation in the pancreatic juice
score: 3.6451162, The American Journal of Gastroenterology, 2001, Queneau, Pierre-Edouard et. al.

Classification and Pathology
score: 3.6437267, Surgical Clinics of North America, 2008, Wu, Julie M.; Montgomery, Elizabeth

Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.
score: 3.6414313, British journal of cancer, 1992, Eccles, D M et. al.

Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast.
score: 3.6399775, The Journal of pathology, 2008, Marchiò, C et. al.

Molecular genetic characterization of tamoxifen-associated endometrial cancer
score: 3.6391076, Gynecologic Oncology, 2005, Prasad, Monica et. al.

PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations
score: 3.6380736, Gynecologic Oncology, 2006, Kolasa, I.K. et. al.

Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study.
score: 3.636746, Genes, chromosomes & cancer, 2000, Bridge, J A et. al.

A combined oncogenic pathway signature of BRAF , KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction
score: 3.6365629, Gut, 2012, Tian, Sun et. al.

Chronic myelomonocytic leukemia: lost in classification?
score: 3.6348995, Hematological oncology, 2005, Bowen, David T

Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.
score: 3.6346728, Oncogene, 2004, Taylor, Michael D et. al.

Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization.
score: 3.6335985, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2000, Billings, S D; Meisner, L F; Cummings, O W; Tejada, E

Studies of the p 53 gene mutation in Saudi non-Hodgkin's lymphoma
score: 3.6327111, Cancer Letters, 1996, Ahmad, Mir F. et. al.

BRAF Mutations in Aberrant Crypt Foci and Hyperplastic Polyposis
score: 3.6313318, The American Journal of Pathology, 2005, Beach, Robyn et. al.

Cigarette smoking and K- ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes
score: 3.6282222, Mutation Research-Reviews in Mutation Research, 2009, Porta, Miquel et. al.

Gastrointestinal Stromal Tumors I: Pathology, Pathobiology, Primary Therapy, and Surgical Issues
score: 3.6242891, Seminars in Oncology, 2009, Reichardt, Peter et. al.

Detection of plasma tumor DNA in head and neck squamous cell carcinoma by microsatellite typing and p53 mutation analysis.
score: 3.6229023, Cancer research, 2000, Coulet, F et. al.

Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia.
score: 3.6211162, Genes, chromosomes & cancer, 2011, Giguère, Amélie; Hébert, Josée

Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia.
score: 3.6211162, Genes, chromosomes & cancer, 2011, Giguère, Amélie; Hébert, Josée

Soluble phosphorylated fms-like tyrosine kinase
score: 3.6196699, Leukemia Research, 2007, Ravandi, F. et. al.

Outcome of patients with FLT3-mutated acute myeloid leukemia in first relapse
score: 3.6169944, Leukemia Research, 2010, Ravandi, Farhad et. al.

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase
score: 3.6161423, Oncotarget, 2012, Do, Hongdo; Dobrovic, Alexander

Adrenocortical tumor in a patient with familial adenomatous polyposis: A case associated with a complete inactivating mutation of the APC gene and unusual histological features
score: 3.6155138, Human Pathology, 1998, Wakatsuki, Shigeru et. al.

Mechanisms of mutations in myeloproliferative neoplasms
score: 3.6131113, Best Practice & Research Clinical Haematology, 2009, Levine, Ross L.

Activity (transcription) of the genes for MLH1, MSH2 and p53 in sporadic colorectal tumours with micro-satellite instability
score: 3.613041, British Journal of Cancer, 2004, Tou, S I H; Drye, E R; Boulos, P B; Hollingsworth, S J

Imatinib mesylate (STI571) for myeloid malignancies other than CML
score: 3.6127266, Leukemia Research, 2004, Krystal, Geoffrey W

VHL Protein Alterations in Sporadic Renal Cell Carcinoma
score: 3.6117239, Clinical Oncology, 2007, Giménez-Bachs, J.M. et. al.

Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers.
score: 3.6114467, Oncogene, 1997, Simms, L A et. al.

Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma.
score: 3.6099532, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Fitzgibbon, J et. al.

Mutations of the adenomatous polyposis coli gene in areca quid and tobacco-associated oral squamous cell carcinomas in Taiwan.
score: 3.6095719, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2002, Kok, Sang-Heng et. al.

Complementing mutations in core binding factor leukemias: from mouse models to clinical applications.
score: 3.6090536, Oncogene, 2008, Müller, A M S; Duque, J; Shizuru, J A; Lübbert, M

The R72P P53 mutation is associated with familial breast cancer in Jewish women.
score: 3.6089185, British journal of cancer, 2005, Ohayon, T et. al.

Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc.
score: 3.6088394, The Journal of investigative dermatology, 2009, Paulson, Kelly G et. al.

p53 is an independent pre-treatment markers for long-term survival in stage II and III colorectal cancers: an analysis of interaction between genetic markers and fluorouracil-based adjuvant therapy
score: 3.608549, Cancer Letters, 2004, Tang, Reiping et. al.

WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.
score: 3.608442, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Kawasaki, Takako et. al.

The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia.
score: 3.6083655, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Whitman, S P et. al.

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice
score: 3.608007, Cancer Cell, 2009, Dhomen, Nathalie et. al.

Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer
score: 3.6078519, British Journal of Cancer, 2010, Di Fiore, F et. al.

Diet, Helicobacter pylori, and p53 mutations in gastric cancer: a molecular epidemiology study in Italy.
score: 3.6073085, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Palli, D et. al.

Extrarenal rhabdoid tumors of soft tissue: clinicopathological and molecular genetic review and distinction from other soft-tissue sarcomas with rhabdoid features.
score: 3.6065247, Pathology international, 2006, Oda, Yoshinao; Tsuneyoshi, Masazumi

Oncogenic activating mutations are associated with local copy gain.
score: 3.6034989, Molecular cancer research : MCR, 2009, Modrek, Barmak et. al.

Molecular classification of neoplasms of the pancreas
score: 3.6020209, Human Pathology, 2009, Hruban, Ralph H.; Adsay, N. Volkan

Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.
score: 3.6014, Cancer research, 2006, Toyooka, Shinichi et. al.

Mutations in the BRAF and N-ras genes in childhood acute lymphoblastic leukaemia.
score: 3.6002707, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Gustafsson, B et. al.

Whole genome comparison of allelic imbalance between noninvasive and invasive small-sized lung adenocarcinomas.
score: 3.6001147, Cancer research, 2009, Nakanishi, Hirofumi et. al.

A pilot study of the Histone-Deacetylase inhibitor Givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms.
score: 3.5991451, British journal of haematology, 2010, Rambaldi, Alessandro et. al.

Uniparentalism in sporadic colorectal cancer is independent of imprint status, and coordinate for chromosomes 14 and 18
score: 3.5966033, Cancer Genetics and Cytogenetics, 2009, Darbary, Huferesh K. et. al.

Discovery of genomic alterations through coregulation analysis of closely linked genes: a frequent gain in 17q25.3 in prostate cancer.
score: 3.5961062, Annals of the New York Academy of Sciences, 2010, Bermudo, Raquel et. al.

ras activation in human tumors and in animal model systems.
score: 3.5942958, Environmental Health Perspectives, 1991, Corominas, M et. al.

Emerging role of gefitinib in the treatment of non-small-cell lung cancer (NSCLC)
score: 3.5921286, Drug design, development and therapy, 2010, Tiseo, M; Bartolotti, M; Gelsomino, F; Bordi, P

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition
score: 3.5915242, British Journal of Cancer, 2007, Xu, W et. al.

Clear Cell Sarcoma or Malignant Melanoma of Soft Parts
score: 3.5914988, Cancer Genetics and Cytogenetics, 1998, Aue, Georg et. al.

Systematic review of genetic influences on the prognosis of colorectal cancer.
score: 3.591349, The British journal of surgery, 2004, Anwar, S; Frayling, I M; Scott, N A; Carlson, G L

High incidence of point mutations of p53 suppressor oncogene in patients with myelodysplastic syndrome among atomic-bomb survivors: a 10-year follow-up.
score: 3.5870463, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002, Imamura, N; Abe, K; Oguma, N

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition.
score: 3.5853393, British journal of cancer, 2007, Xu, W et. al.

FIP1L1-PDGFRA in eosinophilic disorders: Prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature
score: 3.5849277, Leukemia Research, 2006, Pardanani, A. et. al.

Combined classical cytogenetics and microarray-based genomic copy number analysis reveal frequent 3;5 rearrangements in clear cell renal cell carcinoma.
score: 3.584767, Genes, chromosomes & cancer, 2010, Pei, Jianming et. al.

Chromosomal Abnormalities and Molecular Markers in Myeloproliferative Disorders
score: 3.5817773, Seminars in Hematology, 2005, Bench, Anthony J.; Pahl, Heike L.

Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders.
score: 3.5812277, Genes, chromosomes & cancer, 2005, Mitelman, Felix; Mertens, Fredrik; Johansson, Bertil

Allelic deletions at chromosome 11q22-q23.1 and 11q25-qterm are frequent in sporadic breast but not colorectal cancers.
score: 3.5807923, Oncogene, 1997, Koreth, J; Bakkenist, C J; McGee, J O

Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry.
score: 3.5801055, British journal of cancer, 1998, Marsh, K L; Varley, J M

Chromosome 17p deletions and p53 mutations in renal cell carcinoma.
score: 3.5792189, Cancer research, 1993, Reiter, R E; Anglard, P; Liu, S; Gnarra, J R; Linehan, W M

Prevalence and clinical outcomes of the 46/1 haplotype, Janus kinase 2 mutations, and ten-eleven translocation 2 mutations in Budd-Chiari syndrome and their impact on thrombotic complications post liver transplantation.
score: 3.5789831, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2012, Westbrook, Rachel H et. al.

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.
score: 3.5786857, Proceedings of the National Academy of Sciences of the United States of America, 1991, Børresen, A L et. al.

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.
score: 3.5786547, Pigment cell & melanoma research, 2009, Madhunapantula, Subbarao V; Robertson, Gavin P

Clinical, histopathologic, and genetic features of pediatric primary myelofibrosis--an entity different from adults.
score: 3.5784655, American journal of hematology, 2012, DeLario, Melissa R et. al.

Identification of a 1.2 Kb cDNA fragment from a region on 9p21 commonly deleted in multiple tumor types
score: 3.5783163, Cancer Genetics and Cytogenetics, 2001, Gursky, Susan; Olopade, Olufunmilayo I; Rowley, Janet D

Discovering Tumor Suppressor Genes Through Genome-Wide Copy Number Analysis
score: 3.576702, Current Genomics, 2010, Rothenberg, S. Michael; Settleman, Jeff

Somatic and germline mutation in GRIM-19 , a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid
score: 3.5765356, British Journal of Cancer, 2005, Máximo, V et. al.

Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa.
score: 3.5751968, International journal of cancer. Journal international du cancer, 2004, Szymańska, Katarzyna et. al.

The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status-clinical correlates in a study of 226 consecutive patients.
score: 3.5727856, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Pardanani, A et. al.

The R72P P53 mutation is associated with familial breast cancer in Jewish women
score: 3.5698484, British Journal of Cancer, 2005, Ohayon, T et. al.

PDGF receptors as cancer drug targets
score: 3.5692647, Cancer Cell, 2003, Pietras, Kristian et. al.

Acute leukemias in children with Down syndrome
score: 3.5691918, Molecular Genetics and Metabolism, 2012, Seewald, Laura et. al.

Tissue microarrays: applications in study of p16 and p53 alterations in Ewing's cell lines
score: 3.568926, Diagnostic Pathology, 2008, Noguera, Rosa et. al.

Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer.
score: 3.5682724, Cancer, 2009, Jiang, Yixing et. al.

Targeting the epigenome for treatment of cancer.
score: 3.5673655, Oncogene, 2012, Geutjes, E-J; Bajpe, P K; Bernards, R

Molecular Bases of Cutaneous and Uveal Melanomas
score: 3.566815, Pathology Research International, 2011, Gaudi, Sudeep; Messina, Jane L.

Molecular Pathogenesis of Pituitary Tumors
score: 3.5658423, Frontiers in Neuroendocrinology, 2000, Farrell, William E.; Clayton, Richard N.

Molecular biology of gastric cancer
score: 3.5656962, Seminars in Radiation Oncology, 2002, El-Rifai, Wa'el; Powell, Steven M.

The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting.
score: 3.5655354, The Journal of pathology, 2011, Kern, Scott E; Shi, Chanjuan; Hruban, Ralph H

Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer.
score: 3.5644873, Cancer research, 1992, Brachman, D G et. al.

High Prevalence of Activated Intraepithelial Cytotoxic T Lymphocytes and Increased Neoplastic Cell Apoptosis in Colorectal Carcinomas with Microsatellite Instability
score: 3.5641364, The American Journal of Pathology, 1999, Dolcetti, Riccardo et. al.

Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues.
score: 3.5634137, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Goldman, J M et. al.

Genetic changes in epithelial solid neoplasia.
score: 3.5633314, Cancer research, 1994, Rodriguez, E; Sreekantaiah, C; Chaganti, R S

CD34-reactive tumors of the skin. An updated review of an ever-growing list of lesions.
score: 3.5623857, Journal of cutaneous pathology, 2008, Tardío, Juan C

Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia
score: 3.5613204, BMC Cancer, 2012, Mansur, Marcela Braga et. al.

Genotypic analysis of primary and metastatic cutaneous melanoma
score: 3.5611205, Cancer Genetics and Cytogenetics, 2003, Rao, U.N.M.; Jones, M.W.; Finkelstein, S.D.

Antiretroviral activity of 5-azacytidine during treatment of a HTLV-1 positive myelodysplastic syndrome with autoimmune manifestations
score: 3.560236, Virology Journal, 2012, Diamantopoulos, Panagiotis T et. al.

Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer.
score: 3.5588072, International journal of cancer. Journal international du cancer, 2002, Jonsson, Björn-Anders et. al.

Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC–DUX4 fusion gene event
score: 3.5586753, Cancer Genetics and Cytogenetics, 2009, Yoshimoto, Maisa et. al.

APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression
score: 3.5567477, Gastroenterology, 2006, Janssen, Klaus–Peter et. al.

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
score: 3.5565127, Cancer research, 1996, Herman, J G; Jen, J; Merlo, A; Baylin, S B

Molecular diagnostics of gliomas: state of the art
score: 3.5541168, Acta Neuropathologica, 2010, Riemenschneider, Markus J. et. al.

Non-CpG cytosine methylation of p53 exon 5 in non-small cell lung carcinoma
score: 3.5540936, Lung Cancer, 2005, Kouidou, Sofia et. al.

Old and New Insights in the Treatment of Thyroid Carcinoma
score: 3.5531678, Journal of Thyroid Research, 2010, Gasent Blesa, Joan Manel et. al.

Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: a diagnostic challenge.
score: 3.5531543, American journal of hematology, 2010, Arredondo, Angela R et. al.

Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma.
score: 3.5527277, Proceedings of the National Academy of Sciences of the United States of America, 1992, Iavarone, A; Matthay, K K; Steinkirchner, T M; Israel, M A

Signal transduction therapy of cancer
score: 3.5518915, Molecular Aspects of Medicine, 2010, Levitzki, Alexander; Klein, Shoshana

Ras gene mutations in 7,12-dimethylbenz[ a]anthracene (DMBA)-induced rat sarcomas
score: 3.5518522, Cancer Letters, 2001, Walentinsson, Anna; Levan, Göran

Absence of p21 expression is associated with abnormal p53 in human breast carcinomas.
score: 3.550823, British Journal of Cancer, 1997, Ellis, P. A. et. al.

Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines
score: 3.5501162, Leukemia Research, 2002, Fleckenstein, Diana S et. al.

p53 loss and point mutations are associated with suppression of apoptosis and progression of CML into myeloid blastic crisis
score: 3.5496615, Cancer Genetics and Cytogenetics, 1997, Stuppia, Liborio et. al.

Absence of PPP2R1B gene alterations in primary ovarian cancers.
score: 3.5494013, Oncogene, 1999, Campbell, I G; Manolitsas, T

Genetics of Endometrial Cancers
score: 3.5488292, Obstetrics and Gynecology International, 2010, Okuda, Tsuyoshi et. al.

Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus
score: 3.5465407, Human Pathology, 1998, Park, Won-Sang et. al.

WT1 transcript amount discriminates secondary or reactive eosinophilia from idiopathic hypereosinophilic syndrome or chronic eosinophilic leukemia.
score: 3.5462298, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Cilloni, D et. al.

HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53
score: 3.5460309, Experimental and Molecular Pathology, 2013, Ghosh, Anil et. al.

Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers.
score: 3.5458319, International journal of cancer. Journal international du cancer, 2007, Park, Hye-Won et. al.

Mutational analysis of gene families in human cancer
score: 3.5444503, Current Opinion in Genetics & Development, 2005, Bardelli, Alberto; Velculescu, Victor E

Selective mutation of codons 204 and 213 of the p53 gene in rat tumors induced by alkylating N-nitroso compounds.
score: 3.5444335, Cancer research, 1992, Ohgaki, H et. al.

Microsatellite instability and p53 mutation associated with tumor progression in dermatofibrosarcoma protuberans
score: 3.5440136, Human Pathology, 2004, Takahira, Tomonari et. al.

p53 gene mutation pattern in rat liver tumors induced by vinyl chloride.
score: 3.5437576, Cancer research, 1997, Barbin, A et. al.

CpG island methylation is a common finding in colorectal cancer cell lines.
score: 3.5435228, British journal of cancer, 2003, Suter, C M et. al.

Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation.
score: 3.5435136, Molecular cancer research : MCR, 2010, Ahmad, Rehan et. al.

BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q within a new minimal deletion region
score: 3.543029, Cancer Genetics and Cytogenetics, 2008, Wozniak, K. et. al.

Restriction Endonuclease-Mediated Selective Polymerase Chain Reaction
score: 3.5419649, The American Journal of Pathology, 1998, Ward, Robyn et. al.

Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas.
score: 3.5404533, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2010, Dacic, Sanja et. al.

K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.
score: 3.5390901, Cancer research, 2000, Guerrero, S et. al.

p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival.
score: 3.5390643, British Journal of Cancer, 1996, Barbareschi, M. et. al.

Evidence and expertise in the management of polycythemia vera and essential thrombocythemia.
score: 3.5387464, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Finazzi, G; Barbui, T

Comparison of hypoplastic myelodysplastic syndrome (MDS) with normo-/hypercellular MDS by International Prognostic Scoring System, cytogenetic and genetic studies.
score: 3.5385693, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Huang, T-C et. al.

β-Catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5- f]quinoline in CDF 1 mice
score: 3.537607, Cancer Letters, 2003, Huang, Hervé et. al.

Can molecular biomarker-based patient selection in Phase I trials accelerate anticancer drug development?
score: 3.5332063, Drug Discovery Today, 2010, Carden, Craig P. et. al.

Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis.
score: 3.5326251, Cancer research, 1994, Miyake, S; Nagai, K; Yoshino, K; Oto, M; Endo, M; Yuasa, Y

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders.
score: 3.5321518, British journal of pharmacology, 2008, Jensen, B M; Akin, C; Gilfillan, A M

An unexpected new role of mutant Ras: perturbation of human embryonic development
score: 3.5318116, Journal of Molecular Medicine (Berlin, Germany), 2007, Kratz, Christian P.; Niemeyer, Charlotte M.; Zenker, Martin

Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation.
score: 3.5294082, Cancer science, 2007, Uchida, Akiko et. al.

Application of genomics for risk stratification of childhood acute lymphoblastic leukaemia: from bench to bedside?
score: 3.528834, British journal of haematology, 2010, Izraeli, Shai

Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
score: 3.5285261, Journal of Hematology & Oncology, 2011, Takahashi, Shinichiro

Pancreatic cancer: Promise for personalised medicine?
score: 3.5282965, Cancer Letters, 2012, Braat, Henri et. al.

Ovarian Cancer: In Search of Better Marker Systems Based on DNA Repair Defects
score: 3.5276045, International Journal of Molecular Sciences, 2013, Varga, Dominic et. al.

Simultaneous expression of the ras p21 and p53 proteins in human endometrial carcinomas
score: 3.5267274, Acta Histochemica, 1996, Miturski, Roman; Semczuk, Andrzej; Jakowicki, Jerzy

Molecular bases of myelodysplastic syndromes: lessons from animal models.
score: 3.5263566, Journal of cellular physiology, 2009, Komeno, Yukiko; Kitaura, Jiro; Kitamura, Toshio

Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families
score: 3.5260717, BMC Medicine, 2008, Kanter-Smoler, Gunilla et. al.

Immunohistochemical Surrogates for Genetic Alterations of CCDN1, PML, ALK, and NPM1 Genes in Lymphomas and Acute Myeloid Leukemia
score: 3.5251792, Best Practice & Research Clinical Haematology, 2010, Falini, Brunangelo et. al.

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
score: 3.5250408, Cancer Cell, 2006, Ji, Hongbin et. al.

Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer?
score: 3.5241967, British journal of cancer, 2007, Uramoto, H; Mitsudomi, T

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis
score: 3.523484, Molecular Cancer, 2010, Bergeron, Sébastien et. al.

RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer.
score: 3.5233899, Oncogene, 2007, Bignone, P A et. al.

Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression
score: 3.5223527, Cancer Genetics and Cytogenetics, 2010, Brassesco, María Sol et. al.

Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer.
score: 3.5216286, British journal of cancer, 2008, Tang, Z et. al.

Lung cancer in never smokers – a review
score: 3.5215156, European Journal of Cancer, 2012, Couraud, Sébastien et. al.

ERG Deregulation Induces PIM1 Over-Expression and Aneuploidy in Prostate Epithelial Cells
score: 3.5205684, PLoS ONE, 2011, Magistroni, Vera et. al.

Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients.
score: 3.5193506, British journal of cancer, 2011, Rawson, J B et. al.

Pancreatic Carcinogenesis
score: 3.5168601, Pancreatology, 2008, Koorstra, Jan-Bart M. et. al.

Actualités sur la compréhension et le traitement des mastocytoses systémiques
score: 3.5167425, La Revue de médecine interne, 2009, Georgin-Lavialle, S. et. al.

Detection of a Ha- ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5- f]quinoline-induced mouse forestomach tumors
score: 3.5162353, Cancer Letters, 1992, Makino, H. et. al.

Loss of heterozygosity of the von hippel lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas
score: 3.5150808, Human Pathology, 1998, Fogt, Franz et. al.

Treatment options for hydroxyurea-refractory disease complications in myeloproliferative neoplasms: JAK2 inhibitors, radiotherapy, splenectomy and transjugular intrahepatic portosystemic shunt.
score: 3.5148077, European journal of haematology, 2010, Mishchenko, Elena; Tefferi, Ayalew

Implementation of Formalin-Fixed, Paraffin-Embedded Cell Line Pellets as High-Quality Process Controls in Quality Assessment Programs for KRAS Mutation Analysis
score: 3.5145402, The Journal of Molecular Diagnostics, 2012, Dijkstra, Jeroen R. et. al.

Epithelial E- and P-cadherins: Role and clinical significance in cancer
score: 3.5138314, BBA - Reviews on Cancer, 2012, Paredes, Joana et. al.

Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients.
score: 3.5130124, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Chou, W-C et. al.

Gastrointestinal Stromal Tumors: Molecular Mechanisms and Targeted Therapies
score: 3.5122303, Pathology Research International, 2011, Downs-Kelly, Erinn; Rubin, Brian P.

Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
score: 3.5120527, Cancer research, 1994, Yuan, B et. al.

Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down's syndrome.
score: 3.5114925, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2003, Hirose, Y; Kudo, K; Kiyoi, H; Hayashi, Y; Naoe, T; Kojima, S

APC gene mutations in the mutation cluster region are rare in esophageal cancers
score: 3.5112872, Gastroenterology, 1994, Powell, Steven M. et. al.

Diagnostic value of histology and immunohistochemistry in myelodysplastic syndromes
score: 3.510922, Leukemia Research, 2007, Horny, Hans-Peter; Sotlar, Karl; Valent, Peter

Challenges of detecting EGFR T790M in gefitinib/erlotinib-resistant tumours
score: 3.5108089, Lung Cancer, 2008, Jänne, Pasi A.

Non-mucinous and mucinous subtypes of adenocarcinoma with bronchioloalveolar carcinoma features differ by biomarker expression and in the response to gefitinib
score: 3.5105696, Lung Cancer, 2010, Wislez, Marie et. al.

Genomic instability and target gene mutations in colon cancers with different degrees of allelic shifts.
score: 3.508852, Genes, chromosomes & cancer, 2000, Percesepe, A et. al.

Clinical syndromes of transformation in clonal hematologic disorders
score: 3.5082293, The American Journal of Medicine, 2001, Mintzer, David; Bagg, Adam

Alterations of pRb1-cyclin D1-cdk4/6-p16 INK4A pathway in endometrial carcinogenesis
score: 3.5077112, Cancer Letters, 2004, Semczuk, Andrzej; Jakowicki, Jerzy Andrzej

KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials
score: 3.5059148, International Journal of Radiation Oncology, Biology, Physics, 2013, Kim, Sun Young et. al.

Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma.
score: 3.505398, Genes, chromosomes & cancer, 2010, Mejia-Guerrero, Salvador et. al.

Single-Cell Exome Sequencing and Monoclonal Evolution of a JAK2-Negative Myeloproliferative Neoplasm
score: 3.5049569, Cell, 2012, Hou, Yong et. al.

Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma.
score: 3.5037792, Genes, chromosomes & cancer, 2009, Bonazzi, Vanessa F; Irwin, Darryl; Hayward, Nicholas K

Long-term survival and transmission of INI1 -mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome
score: 3.5007664, British Journal of Cancer, 2007, Ammerlaan, A C J et. al.

EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours.
score: 3.500265, British journal of cancer, 2010, Kim, S; Lim, B; Kim, J

A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases
score: 3.499329, Molecular Cell, 2007, Chen, Huaibin et. al.

Osteopontin expression in papillary thyroid carcinoma and its relationship with the BRAF mutation and tumor characteristics
score: 3.4989349, Journal of the Korean Surgical Society, 2012, Kang, Kyung Ho

Current status of gene expression profiling in the diagnosis and management of acute leukaemia.
score: 3.498872, British journal of haematology, 2009, Bacher, Ulrike; Kohlmann, Alexander; Haferlach, Torsten

EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer.
score: 3.4983627, British journal of cancer, 2011, Ålgars, A et. al.

EWS-Oct-4B , an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours
score: 3.4963443, British Journal of Cancer, 2010, Kim, S; Lim, B; Kim, J

Frequent loss of heterozygosity on chromosomes 7 and 9 in benign epithelial ovarian tumours.
score: 3.4956436, Oncogene, 1997, Roy, W J; Watson, R H; Hitchcock, A; Campbell, I G

Mutations of K-ras oncogene in human adrenal tumours in Taiwan.
score: 3.4953739, British Journal of Cancer, 1998, Lin, S. R.; Tsai, J. H.; Yang, Y. C.; Lee, S. C.

The nature and timing of specific copy number changes in the course of molecular progression in diffuse gliomas: further elucidation of their genetic "life story".
score: 3.4949924, Brain pathology (Zurich, Switzerland), 2011, Jeuken, Judith W M et. al.

Multiplex Ligation-Dependent Probe Amplification
score: 3.4941166, The Journal of Molecular Diagnostics, 2006, Jeuken, Judith et. al.

Glioma cells showing IDH1 mutation cannot be propagated in standard cell culture conditions
score: 3.4926016, British Journal of Cancer, 2011, Piaskowski, S et. al.

Allogeneic stem cell transplantation for myeloproliferative neoplasm in blast phase
score: 3.4887414, Leukemia Research, 2012, Cherington, Chad et. al.

Allogeneic stem cell transplantation for myeloproliferative neoplasm in blast phase
score: 3.4887414, Leukemia Research, 2012, Cherington, Chad et. al.

Allogeneic stem cell transplantation for myeloproliferative neoplasm in blast phase
score: 3.4887414, Leukemia Research, 2012, Cherington, Chad et. al.

Absence of the c-Ha- ras codon 61 point mutation in murine solid tumors induced by subcutaneously applied 7,12-dimethylbenzanthracene
score: 3.4886136, Cancer Letters, 1990, Andrews, D.F.; Collins, S.J.; Reddy, A.L.

Detection of EML4-ALK fusion genes in a few cancer cells from transbronchial cytological specimens utilizing immediate cytology during bronchoscopy
score: 3.4884507, Lung Cancer, 2012, Kanaji, Nobuhiro et. al.

Detection of EML4-ALK fusion genes in a few cancer cells from transbronchial cytological specimens utilizing immediate cytology during bronchoscopy
score: 3.4884507, Lung Cancer, 2012, Kanaji, Nobuhiro et. al.

Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients.
score: 3.4878596, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Pileri, S A et. al.

Identification of two contiguous minimally deleted regions on chromosome 1p36.31–p36.32 in oligodendroglial tumours
score: 3.4878472, British Journal of Cancer, 2004, Dong, Z; Pang, JC-S; Ng, M H; Poon, W S; Zhou, L; Ng, H-K

Diagnostic Evaluation and Classification of Mastocytosis
score: 3.4870401, Immunology and Allergy Clinics of North America, 2006, Valent, Peter

Farnesyl protein transferase inhibitors as potential cancer chemopreventives.
score: 3.4841981, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Kelloff, G J et. al.

Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma
score: 3.4841042, Leukemia Research, 2005, Yang, Yang et. al.

TP53 Mutations in Korean Patients with Non-small Cell Lung Cancer
score: 3.4838857, Journal of Korean Medical Science, 2010, Lee, Eung Bae et. al.

ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance
score: 3.483633, Critical Reviews in Oncology and Hematology, 2007, de Jonge-Peeters, Susan D.P.W.M. et. al.

The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers.
score: 3.4834578, British journal of cancer, 2005, Lawes, D A; Pearson, T; Sengupta, S; Boulos, P B

Detailed deletion mapping of chromosome arm 3p in breast cancers: a 2-cM region on 3p14.3-21.1 and a 5-cM region on 3p24.3-25.1 commonly deleted in tumors.
score: 3.4820019, Genes, chromosomes & cancer, 1997, Matsumoto, S et. al.

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer.
score: 3.4817328, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Reid, Alison H M et. al.

Epithelial E- and P-cadherins: Role and clinical significance in cancer
score: 3.4816331, BBA - Reviews on Cancer, 2012, Paredes, Joana et. al.

Epithelial E- and P-cadherins: Role and clinical significance in cancer
score: 3.4816331, BBA - Reviews on Cancer, 2012, Paredes, Joana et. al.

Epithelial E- and P-cadherins: Role and clinical significance in cancer
score: 3.4816331, BBA - Reviews on Cancer, 2012, Paredes, Joana et. al.

p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan.
score: 3.4813655, British journal of cancer, 2005, Hsieh, L-L et. al.

Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small cell lung cancer patients with an EGFR wild type genotype
score: 3.4801762, Lung Cancer, 2012, Metro, Giulio et. al.

Detection of Loss of Heterozygosity in the p53 Tumor Suppressor Gene Using a PCR-based Assay
score: 3.4800178, Pathology - Research and Practice, 1995, Ridanpää, M.; Anttila, S.; Husgafvel-Pursiainen, K.

Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML)
score: 3.4798444, Critical Reviews in Oncology and Hematology, 2006, Walz, Christoph; Sattler, Martin

Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan.
score: 3.4791918, British journal of cancer, 1999, Hsu, C H; Yang, S A; Wang, J Y; Yu, H S; Lin, S R

Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria
score: 3.4784426, Leukemia Research, 2003, Valent, Peter et. al.

FLT3-activating mutations in acute promyelocytic leukaemia: a rationale for risk-adapted therapy with FLT3 inhibitors
score: 3.4775673, Best Practice & Research Clinical Haematology, 2003, Gilliland, D.Gary

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
score: 3.4768283, British journal of cancer, 1998, Suwa, H et. al.

Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling
score: 3.4767462, Cancer Cell, 2010, Rathinam, Chozhavendan et. al.

Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10
score: 3.4753374, British Journal of Cancer, 2012, Modjtahedi, H et. al.

A Novel Germ-Line Mutation in the Noncoding Region of the p53 Gene in a Li-Fraumeni Family
score: 3.4745242, Cancer Genetics and Cytogenetics, 1998, Barel, Dalit et. al.

Molecular analysis of alterations of the p18INK4c gene in human meningiomas.
score: 3.4735072, Neuropathology and applied neurobiology, 2000, Santarius, T; Kirsch, M; Nikas, D C; Imitola, J; Black, P M

Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer.
score: 3.4713627, Oncogene, 1999, Sunahara, M et. al.

Deregulated expression of c-mos in non-small cell lung carcinomas: relationship with p53 status, genomic instability, and tumor kinetics.
score: 3.470561, Cancer research, 2001, Gorgoulis, V G et. al.

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia.
score: 3.4702984, Genes, chromosomes & cancer, 2003, Reiter, Andreas et. al.

Emerging ethnic differences in lung cancer therapy
score: 3.4697675, British Journal of Cancer, 2008, Sekine, I; Yamamoto, N; Nishio, K; Saijo, N

p53 mutation and expression in lymphoma.
score: 3.4693878, British journal of cancer, 1995, Adamson, D J et. al.

A novel AKT3 mutation in melanoma tumours and cell lines
score: 3.4693721, British Journal of Cancer, 2008, Davies, M A et. al.

Hypermethylation of tumor-related genes in genitourinary cancer cell lines.
score: 3.4678678, Journal of Korean Medical Science, 2001, Chung, W. B. et. al.

Diagnostic Tools in the Indications for Allogeneic Stem Cell Transplantation in Myelodysplastic Syndromes
score: 3.4670297, Biology of Blood and Marrow Transplantation, 2010, Bacher, Ulrike et. al.

Microsatellite Instability Is a Predictive Marker for Survival Benefit from Adjuvant Chemotherapy in a Population-Based Series of Stage III Colorectal Carcinoma
score: 3.4668882, Clinical Colorectal Cancer, 2001, Elsaleh, Hany; Iacopetta, Barry

Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma
score: 3.4667832, Cancer Letters, 2003, Anzola, Mónica et. al.

Bone marrow biopsies of patients with haematopoietic and lymphoid disorders–epidemiology; chromosomal aberrations and molecular pathology
score: 3.4640466, Pathology - Research and Practice, 2012, Hehne, Sophie et. al.

PI3K pathway alterations in cancer: variations on a theme.
score: 3.4631848, Oncogene, 2008, Yuan, T L; Cantley, L C

Prognostic impact of deletions at 1p36 and numerical aberrations in Ewing tumors.
score: 3.4631253, Genes, chromosomes & cancer, 1999, Hattinger, C M et. al.

Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene
score: 3.4622136, Leukemia Research, 2008, Nishioka, Chie et. al.

Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia.
score: 3.4621077, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Stone, R M et. al.

Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer.
score: 3.4620669, The Journal of pathology, 2006, Ogino, S et. al.

The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors
score: 3.4614626, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005, Daya-Grosjean, Leela; Sarasin, Alain

Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome.
score: 3.4607441, British journal of haematology, 2005, Brakensiek, Kai et. al.

Nonrandom chromosomal rearrangements in pancreatic carcinomas.
score: 3.4603021, Cancer, 1992, Johansson, B et. al.

p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study.
score: 3.4596823, British journal of cancer, 1997, Buttitta, F et. al.

Allelic loss at the BRCA1, BRCA2 and TP53 loci in human sporadic breast carcinoma
score: 3.4596332, Cancer Letters, 2000, Katsama, A; Sourvinos, G; Zachos, G; Spandidos, D.A

Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans
score: 3.4582415, The American Journal of Pathology, 2003, Linn, Sabine C. et. al.

Clinical predictors versus epidermal growth factor receptor mutation in gefitinib-treated non-small-cell lung cancer patients
score: 3.4579623, Lung Cancer, 2006, Han, Sae-Won et. al.

Sequencing of the rat β-catenin gene ( Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5- f]quinoline
score: 3.4569601, Gene, 2002, Li, Qingjie et. al.

Clinical implications of SOCS1 methylation in myelodysplastic syndrome.
score: 3.45658, British journal of haematology, 2006, Wu, Shang-Ju et. al.

Interpreting epithelial cancer biology in the context of stem cells: Tumor properties and therapeutic implications
score: 3.4561469, BBA - Reviews on Cancer, 2005, Miller, Stanley J.; Lavker, Robert M.; Sun, Tung-Tien

P53 mutations associated with breast, colorectal, liver, lung, and ovarian cancers.
score: 3.4549267, Environmental Health Perspectives, 1996, Lasky, T; Silbergeld, E

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification
score: 3.453046, The Journal of Molecular Diagnostics, 2004, Aveyard, Joanne S.; Knowles, Margaret A.

New techniques in dermatopathology that help to diagnose and prognosticate melanoma
score: 3.4516509, Clinics in Dermatology, 2009, Carlson, J. Andrew; Ross, Jeffrey S.; Slominski, Andrze J.

THE EWING FAMILY OF TUMORS
score: 3.4516187, The Pediatric Clinics of North America, 1997, Grier, Holcombe E.

The Role of BRAF Mutation and p53 Inactivation during Transformation of a Subpopulation of Primary Human Melanocytes
score: 3.4510936, The American Journal of Pathology, 2009, Yu, Hong et. al.

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.
score: 3.4494858, Oncogene, 2004, Esteller, Manel; Herman, James G

Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia
score: 3.4488692, Leukemia Research, 2000, Guo, Shu-Xia et. al.

mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3- mutated acute myeloid leukemia cells
score: 3.4486053, Molecular Cancer, 2010, Chen, Weina et. al.

Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
score: 3.4481782, Oncogene, 2005, Wang, Yian; Zhang, Zhongqiu; Lubet, Ronald; You, Ming

Germline alterations in the cyclooxygenase-2 gene are not associated with the development of extracolonic manifestations in a large swiss familial adenomatous polyposis kindred.
score: 3.4479452, International journal of cancer. Journal international du cancer, 2000, Humar, B et. al.

Molecular analysis of the secretory phospholipase A2 gene, a candidate of Mom1 gene, in neuroblastomas
score: 3.4468845, Cancer Letters, 1997, Kawamata, Norihiko et. al.

High Throughput Interrogation of Somatic Mutations in High Grade Serous Cancer of the Ovary
score: 3.442494, PLoS ONE, 2011, Matulonis, Ursula A. et. al.

Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
score: 3.4424703, Cancer research, 1990, Miyaki, M et. al.

Acquisition of the Glioblastoma Phenotype during Astrocytoma Progression Is Associated with Loss of Heterozygosity on 10q25-qter
score: 3.4411813, The American Journal of Pathology, 1999, Fujisawa, Hironori et. al.

Mutant metabolic enzymes are at the origin of gliomas.
score: 3.4403709, Cancer research, 2009, Yan, Hai et. al.

Differentiation therapy of human cancer: basic science and clinical applications
score: 3.4390523, Pharmacology and Therapeutics, 2001, Leszczyniecka, Magdalena et. al.

Malignant peripheral nerve sheath tumors with t(X;18). A pathologic and molecular genetic study.
score: 3.438355, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2000, O'Sullivan, M J et. al.

Diet activity, and lifestyle associations with p53 mutations in colon tumors.
score: 3.4383354, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Slattery, Martha L et. al.

Highlights of 2008 in bone marrow biopsy pathology
score: 3.4382057, Journal of Hematopathology, 2009, van der Walt, Jon

Mutations in c-K- ras 2 gene codon 12 during colorectal tumorigenesis in familial adenomatous polyposis
score: 3.43537, Gastroenterology, 1992, Ando, Masayuki et. al.

Nucleophosmin ( NPM1) Mutations in Acute Myeloid Leukemia: An Ongoing (Cytoplasmic) Tale of Dueling Mutations and Duality of Molecular Genetic Testing Methodologies
score: 3.4350802, The Journal of Molecular Diagnostics, 2008, Wertheim, Gerald; Bagg, Adam

Induction of invasive squamous cell carcinomas in the forestomach of (C3H × MSM)F1, MSM, and C3H mice by N-methyl- N-nitrosourea and mutational analysis of the H- ras and p53 genes
score: 3.4303457, Cancer Letters, 1997, Masui, Tsuneo et. al.

High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy
score: 3.4302, Gastroenterology, 2006, Spring, Kevin J. et. al.

Increased frequency of chromosome abnormalities in fibroblasts from hairy cell leukemia patients.
score: 3.4297529, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1997, Haglund, U; Stellan, B; Juliusson, G; Gahrton, G

Cytogenetic aspects of adult primary myelodysplastic syndromes: Clinical implications
score: 3.4281781, Cancer Letters, 2006, Panani, Anna D.; Roussos, Charis

KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas.
score: 3.428178, The Journal of pathology, 2004, Pan, Chin-Chen; Chen, Paul Chih-Hsueh; Chiang, Hung

Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced nonsmall cell lung cancer.
score: 3.4244359, International journal of cancer. Journal international du cancer, 2006, Shih, Jin-Yuan et. al.

Prognostic Significance of NRAS Gene Mutations in Children with Acute Myelogenous Leukemia
score: 3.4233768, Mediterranean Journal of Hematology and Infectious Diseases, 2011, Aly, Rabab M.; El-sharnoby, Mohamed R.; Hagag, Adel A.

Germline Brca2 Heterozygosity Promotes Kras G12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer
score: 3.4230618, Cancer Cell, 2010, Skoulidis, Ferdinandos et. al.

Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instability.
score: 3.422253, Genes, chromosomes & cancer, 2002, Samowitz, Wade S et. al.

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.
score: 3.4218766, Nature genetics, 2009, Dankort, David et. al.

The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma.
score: 3.4213126, Oncogene, 1997, Miller, C W et. al.

The Neurofibromatosis Type 2 Gene Is Mutated in Perineurial Cell Tumors
score: 3.4193827, The American Journal of Pathology, 2001, Lasota, Jerzy et. al.

Transcriptional dysregulation during myeloid transformation in AML.
score: 3.4176327, Oncogene, 2007, Pabst, T; Mueller, B U

Complex landscapes of somatic rearrangement in human breast cancer genomes.
score: 3.4163299, Nature, 2009, Stephens, Philip J et. al.

TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations.
score: 3.4157564, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Zenz, T et. al.

Promoter methylation of the PTEN gene is a common molecular change in breast cancer.
score: 3.415282, Genes, chromosomes & cancer, 2004, García, Jose M et. al.

Epigenomics of cancer- emerging new concepts
score: 3.4149047, Biochimie, 2012, Hassler, Melanie R.; Egger, Gerda

KIT Gene Deletions at the Intron 10−Exon 11 Boundary in GI Stromal Tumors
score: 3.4144245, The Journal of Molecular Diagnostics, 2004, Corless, Christopher L. et. al.

Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas.
score: 3.4142455, Genes, chromosomes & cancer, 2005, Martín-Subero, José Ignacio et. al.

Tumor suppressor gene inactivation in myeloid malignancies
score: 3.4140857, Best Practice & Research Clinical Haematology, 2008, Wong, Jasmine C.; Le Beau, Michelle M.; Shannon, Kevin

CpG island methylation is a common finding in colorectal cancer cell lines
score: 3.4135696, British Journal of Cancer, 2003, Suter, C M et. al.

High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas.
score: 3.4131455, Proceedings of the National Academy of Sciences of the United States of America, 1995, Bianchi, A B et. al.

Gone FISHing: clinical lessons learned in brain tumor molecular diagnostics over the last decade.
score: 3.412368, Brain pathology (Zurich, Switzerland), 2011, Horbinski, Craig; Miller, C Ryan; Perry, Arie

Development of a Quantitative Real-Time Polymerase Chain Reaction Assay for the Detection of the JAK2 V617F Mutation
score: 3.411592, The Journal of Molecular Diagnostics, 2007, Wolstencroft, Elizabeth C. et. al.

Synergistic antitumor efficacy of sequentially combined paclitaxel with sorafenib in vitro and in vivo NSCLC models harboring KRAS or BRAF mutations
score: 3.4110482, Cancer Letters, 2012, Zhang, Xiang-Hua et. al.

Synergistic antitumor efficacy of sequentially combined paclitaxel with sorafenib in vitro and in vivo NSCLC models harboring KRAS or BRAF mutations
score: 3.4110482, Cancer Letters, 2012, Zhang, Xiang-Hua et. al.

Synergistic antitumor efficacy of sequentially combined paclitaxel with sorafenib in vitro and in vivo NSCLC models harboring KRAS or BRAF mutations
score: 3.4110482, Cancer Letters, 2012, Zhang, Xiang-Hua et. al.

Hereditary Genodermatoses with Cancer Predisposition
score: 3.4081984, Hematology/Oncology Clinics of North America, 2010, Gerstenblith, Meg R. et. al.

COL11A1 in FAP polyps and in sporadic colorectal tumors
score: 3.4081432, BMC Cancer, 2001, Fischer, Heléne et. al.

Telomerase activity, P53 mutation and Ki-ras codon 12 point mutation of the peripheral blood in patients with hepato pancreato biliary diseases.
score: 3.4062624, HPB : the official journal of the International Hepato Pancreato Biliary Association, 2002, Yamaguchi, Koji et. al.

Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.
score: 3.406239, Human molecular genetics, 1999, Smyth, I et. al.

NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Disease-Specific Methods and Strategies for Monitoring Relapse following Allogeneic Stem Cell Transplantation. Part I: Methods, Acute Leukemias, and Myelodysplastic Syndromes
score: 3.4057855, Biology of Blood and Marrow Transplantation, 2010, Kröger, Nicolaus et. al.

Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders.
score: 3.4052282, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Visconte, V; Makishima, H; Maciejewski, J P; Tiu, R V

Clear cell sarcoma of the mediastinum
score: 3.4033773, Annals of Diagnostic Pathology, 2009, Tirabosco, Roberto et. al.

Gene Expression With Prognostic Implications in Cytogenetically Normal Acute Myeloid Leukemia
score: 3.4026845, Seminars in Oncology, 2008, Baldus, Claudia D.; Bullinger, Lars

A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALK fusion gene
score: 3.4025618, BMC Cancer, 2012, Tanaka, Hisashi et. al.

Interleukin-8 in non-small cell lung carcinoma: Relation with angiogenic pattern and p53 alterations
score: 3.4013828, Lung Cancer, 2005, Boldrini, Laura et. al.

Molecular Aspects of Melanocytic Dysplastic Nevi
score: 3.4011849, The Journal of Molecular Diagnostics, 2002, Hussein, Mahmoud Rezk Abd-Elwahed; Wood, Gary Stewart

Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers.
score: 3.4009757, Cancer research, 1998, Nomoto, S et. al.

The role of MLH1 , MSH2 and MSH6 in the development of multiple colorectal cancers
score: 3.400937, British Journal of Cancer, 2005, Lawes, D A; Pearson, T; SenGupta, S; Boulos, P B

Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities.
score: 3.3997337, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002, Pedersen-Bjergaard, J et. al.

Dual MET–EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer
score: 3.3996361, British Journal of Cancer, 2008, Tang, Z et. al.

E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma.
score: 3.3994616, Oncogene, 2004, Saito, Tsuyoshi et. al.

Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice.
score: 3.3982679, Cancer research, 2007, Parikh, Chaitali; Subrahmanyam, Ramesh; Ren, Ruibao

PLAG1 expression in mesenchymal tumors: an immunohistochemical study with special emphasis on the pathogenetical distinction between soft tissue myoepithelioma and pleomorphic adenoma of the salivary gland.
score: 3.3969206, Pathology international, 2012, Matsuyama, Atsuji; Hisaoka, Masanori; Hashimoto, Hiroshi

Deficient mismatch repair system in patients with sporadic advanced colorectal cancer.
score: 3.3968156, British journal of cancer, 2009, Koopman, M et. al.

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling
score: 3.3961315, BBA - Reviews on Cancer, 2000, Vazquez, Francisca; Sellers, William R

Analysis of p53 gene mutations and loss of heterozygosity for loci on chromosome 9q in basal cell carcinoma
score: 3.3945562, Cancer Letters, 1994, Konishi, Keisuke et. al.

Farnesyl transferase inhibitors in myeloid malignancies
score: 3.3928661, Blood Reviews, 2003, Lancet, Jeffrey E; Karp, Judith E

Oncogenic Pathways, Molecularly Targeted Therapies, and Highlighted Clinical Trials in Non–Small-Cell Lung Cancer (NSCLC)
score: 3.3924486, Clinical Lung Cancer, 2012, Reungwetwattana, Thanyanan et. al.

All along the watchtower: Is the cilium a tumor suppressor organelle?
score: 3.3920193, BBA - Reviews on Cancer, 2008, Mans, Dorus A.; Voest, Emile E.; Giles, Rachel H.

Central neurocytomas are genetically distinct from oligodendrogliomas and neuroblastomas.
score: 3.3915362, Histopathology, 2000, Tong, C Y; Ng, H K; Pang, J C; Hu, J; Hui, A B; Poon, W S

Advances in understanding cancer genomes through second-generation sequencing.
score: 3.3905512, Nature reviews. Genetics, 2010, Meyerson, Matthew; Gabriel, Stacey; Getz, Gad

Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.
score: 3.3900708, Genes, chromosomes & cancer, 2004, Kittiniyom, Kanokwan et. al.

The biology and treatment of EML4-ALK non-small cell lung cancer
score: 3.3899288, European Journal of Cancer, 2010, Sasaki, Takaaki et. al.

An overview of apoptosis and the prevention of colorectal cancer
score: 3.388503, Critical Reviews in Oncology and Hematology, 2006, Watson, Alastair J.M.

Single base instability is promoted in vulvar lichen sclerosus.
score: 3.3872763, The Journal of investigative dermatology, 2007, Tapp, Ronald A et. al.

Genotype to phenotype: Analyzing the effects of inherited mutations in colorectal cancer families
score: 3.3872198, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2010, Heinen, Christopher D.

Emerging treatments for essential thrombocythemia
score: 3.3868885, Journal of blood medicine, 2011, Okoli, Steven; Harrison, Claire

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway
score: 3.385609, Gastroenterology, 2009, Trobridge, Patty et. al.

Gastrointestinal stromal tumor (GIST) pathogenesis, familial GIST, and animal models
score: 3.3852844, Seminars in Diagnostic Pathology, 2006, Antonescu, Cristina R.

MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study.
score: 3.384586, European journal of human genetics : EJHG, 2012, Gausachs, Mireia et. al.

Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: Considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers
score: 3.3840217, BMC Genetics, 2006, van der Heijden, Michiel S et. al.

ras gene activation in rat tumors induced by benzidine congeners and derived dyes.
score: 3.3831418, Cancer research, 1990, Reynolds, S H et. al.

Signal transduction in the human thyrocyte and its perversion in thyroid tumors
score: 3.3801921, Molecular and Cellular Endocrinology, 2010, Roger, Pierre P. et. al.

TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status
score: 3.3794787, Journal of Translational Medicine, 2010, Herreros-Villanueva, Marta et. al.

DNA methylation based biomarkers: Practical considerations and applications
score: 3.3783025, Biochimie, 2012, How Kit, Alexandre; Nielsen, Helene Myrtue; Tost, Jörg

DNA methylation based biomarkers: Practical considerations and applications
score: 3.3783025, Biochimie, 2012, How Kit, Alexandre; Nielsen, Helene Myrtue; Tost, Jörg

Splenic histopathological patterns in chronic myelomonocytic leukemia with clinical correlations: reinforcement of the heterogeneity of the syndrome
score: 3.3776068, Leukemia Research, 2003, Steensma, David P.; Tefferi, Ayalew; Li, Chin-Yang

Deregulation of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in basal cell carcinoma.
score: 3.3764442, The British journal of dermatology, 2009, Kanellou, P; Zaravinos, A; Zioga, M; Spandidos, D A

Genomewide assessment of genetic alterations in DMBA-induced rat sarcomas: cytogenetic, CGH, and allelotype analyses reveal recurrent DNA copy number changes in rat chromosomes 1, 2, 4, and 7.
score: 3.3760094, Genes, chromosomes & cancer, 2000, Walentinsson, A et. al.

Alternative splicing and mutation status of CHEK2 in stage III breast cancer.
score: 3.3726745, Oncogene, 2004, Staalesen, Vidar et. al.

Cytogenetics and Molecular Genetics of Acute Lymphoblastic Leukemia
score: 3.3719049, Hematology/Oncology Clinics of North America, 2009, Mrózek, Krzysztof; Harper, David P.; Aplan, Peter D.

Expression of NRG1 and its receptors in human bladder cancer
score: 3.3717702, British Journal of Cancer, 2011, Forster, J A; Paul, A B; Harnden, P; Knowles, M A

Genomic instability and the selection of treatments for cancer.
score: 3.3702597, The Journal of pathology, 2010, Martin, Sarah A et. al.

Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours.
score: 3.3698738, British journal of cancer, 2005, Marian, C et. al.

CBFA2, frequently rearranged in leukemia, is not responsible for a familial leukemia syndrome.
score: 3.3692565, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1997, Legare, R D et. al.

Novel germline p16 mutation in familial malignant melanoma in southern Sweden.
score: 3.3691563, Cancer research, 1996, Borg, A et. al.

Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver
score: 3.368196, Cancer Genetics and Cytogenetics, 2001, Sowery, Richard D et. al.

Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors
score: 3.3675944, Medical Oncology (Northwood, London, England), 2013, Cantile, Monica et. al.

Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma.
score: 3.3672599, Cancer research, 1994, Shiseki, M et. al.

HSP27 expression in primary colorectal cancers is dependent on mutation ofKRASand PI3K/AKT activation status and is independent ofTP53
score: 3.367005, Experimental and Molecular Pathology, 2013, Ghosh, Anil et. al.

Frequent retention of heterozygosity for point mutations in p53 and Ikaros in N-ethyl- N-nitrosourea-induced mouse thymic lymphomas
score: 3.3667425, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005, Kakinuma, Shizuko et. al.

The myelodysplastic syndromes: towards a functional classification
score: 3.3666667, Blood Reviews, 1998, Mijović, A.; Mufti, G.J.

Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?
score: 3.3662246, BBA - Reviews on Cancer, 2005, Pretlow, Theresa P.; Pretlow, Thomas G.

Deletion of P15 (MTS2) in Head and Neck Squamous Cell Carcinomas
score: 3.3658456, Journal of Surgical Research, 1998, Roesler, John M. et. al.

Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma
score: 3.3649617, Human Pathology, 2012, Kipp, Benjamin R. et. al.

Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas.
score: 3.3637508, The Journal of pathology, 2004, Reinacher-Schick, Anke et. al.

O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.
score: 3.3631652, Cancer research, 2001, Wolf, P; Hu, Y C; Doffek, K; Sidransky, D; Ahrendt, S A

Mutated Ras peptides as vaccines in immunotherapy of cancer.
score: 3.3631298, Vox sanguinis, 1998, Gjertsen, M K; Gaudernack, G

Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
score: 3.3621788, Breast Cancer Research, 2005, Reis-Filho, Jorge S et. al.

Allogeneic haematopoietic cell transplantation for myelofibrosis in 30 patients 60-78 years of age.
score: 3.3583814, British journal of haematology, 2011, Samuelson, Scott et. al.

Detection of Aberrations of 17p and p53 Gene in Gastrointestinal Cancers by Dual (Two-color) Fluorescence In Situ Hybridization and GeneChip p53 Assay
score: 3.3580331, Cancer Genetics and Cytogenetics, 2000, Takahashi, Yasuo et. al.

Gastric adenocarcinoma and Helicobacter pylori: Correlation with p53 mutation and p27 immunoexpression
score: 3.3573811, Cancer Epidemiology, 2010, André, Angela Rosa et. al.

Point mutations of the topoisomerase IIalpha gene in patients with small cell lung cancer treated with etoposide.
score: 3.3571434, Cancer research, 1996, Kubo, A et. al.

PROX1 is a predictor of survival for gliomas WHO grade II
score: 3.355401, British Journal of Cancer, 2011, Elsir, T et. al.

A recurrent duodenal gastrointestinal stromal tumor with a frameshift mutation resulting in a stop codon in KIT exon 13.
score: 3.3551545, Genes, chromosomes & cancer, 2005, Vu, Hoang Anh et. al.

A novel loss-of-function mutation (N48K) in the PTEN gene in a Spanish patient with Cowden disease.
score: 3.3539097, The Journal of investigative dermatology, 2003, Vega, Ana et. al.

A method to detect ras point mutations in small subpopulations of cells
score: 3.353094, Analytical Biochemistry, 1991, Chen, James; Viola, Michael V.

Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms.
score: 3.3524534, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Abdel-Wahab, O et. al.

A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene.
score: 3.3517677, Genes, chromosomes & cancer, 2010, Kohno, Takashi et. al.

Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside.
score: 3.3514605, The Journal of investigative dermatology, 2008, Hocker, Thomas L; Singh, Meena K; Tsao, Hensin

Urticaria pigmentosa
score: 3.3513804, Immunology and Allergy Clinics of North America, 2004, Brockow, Knut

Mammalian gene studies
score: 3.3508917, Current Opinion in Biotechnology, 1994,

Peritoneal exfoliative cytology and Ki- ras mutational analysis in patients with pancreatic adenocarcinoma
score: 3.3506809, Cancer Letters, 1995, Rall, Christopher J.N. et. al.

Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers
score: 3.3496195, Lung Cancer, 2007, Costa, Daniel B. et. al.

KIT expression in normal and neoplastic renal tissues: immunohistochemical and molecular genetic analysis.
score: 3.349554, Pathology international, 2005, Kato, Noriko et. al.

Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
score: 3.3485227, BBA - Reviews on Cancer, 2007, Pardali, Katerina; Moustakas, Aristidis

Molecular changes in the Ki-ras and APC genes in colorectal adenomas and carcinomas arising in the same patient.
score: 3.347741, The Journal of pathology, 2001, Zauber, N P et. al.

Genetic alterations in DNA diploid, aneuploid and multiploid colorectal carcinomas identified by the crypt isolation technique.
score: 3.3454516, International journal of cancer. Journal international du cancer, 2000, Sugai, T et. al.

Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation.
score: 3.3453923, Cancer research, 2007, Godin-Heymann, Nadia et. al.

Capturing the Molecular and Biological Diversity of High-Grade Astrocytoma in Genetically Engineered Mouse Models
score: 3.3446736, Oncotarget, 2012, Chow, Lionel M.L.; Baker, Suzanne J.

Assessment of molecular events in squamous and non-squamous cell lung carcinoma
score: 3.3446618, Lung Cancer, 2006, Yakut, Tahsin et. al.

Genes, chromosomes, and rhabdomyosarcoma.
score: 3.3437377, Genes, chromosomes & cancer, 1999, Anderson, J; Gordon, A; Pritchard-Jones, K; Shipley, J

Allogeneic Stem Cell Transplantation for Myeloproliferative Neoplasm in Blast Phase
score: 3.3432739, Leukemia Research, 2012, Cherington, Chad et. al.

MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma.
score: 3.3431635, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Chen, Yao-Tseng et. al.

Activating Gs α mutation at the arg 201 codon in liposclerosing myxofibrous tumor
score: 3.3428134, Human Pathology, 2003, Matsuba, Atsushi et. al.

Clinical Applications of Epigenetic Markers and Epigenetic Profiling in Myeloid Malignancies
score: 3.3416838, Seminars in Oncology, 2012, McDevitt, Michael A.

p53 Mutation in epithelial ovarian carcinoma and borderline ovarian tumor
score: 3.3412615, Cancer Genetics and Cytogenetics, 1995, Lee, Je-Ho et. al.

Combined Targeting of BRAF and CRAF or BRAF and PI3K Effector Pathways Is Required for Efficacy in NRAS Mutant Tumors
score: 3.3412071, PLoS ONE, 2009, Jaiswal, Bijay S. et. al.

Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
score: 3.3411576, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2006, Pavelić, Krešimir et. al.

Chronic exposure to benzene results in a unique form of dysplasia
score: 3.3396377, Leukemia Research, 2005, Irons, Richard D. et. al.

Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas.
score: 3.3392198, Carcinogenesis, 2006, Ueda, Shinobu et. al.

Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib
score: 3.3363385, Experimental Cell Research, 2012, Kinsella, Paula et. al.

let-7 microRNA expression is reduced in bronchioloalveolar carcinoma, a non-invasive carcinoma, and is not correlated with prognosis
score: 3.3361558, Lung Cancer, 2007, Inamura, Kentaro et. al.

Down-Regulation of Nitric Oxide Synthase-2 and Cyclooxygenase-2 Pathways by p53 in Squamous Cell Carcinoma
score: 3.3357866, The American Journal of Pathology, 2003, Gallo, Oreste et. al.

Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer
score: 3.3357166, Cancer Genetics and Cytogenetics, 2010, Bernardi, Caroline C. et. al.

Differences in KRAS mutation spectrum in lung cancer cases between African Americans and Caucasians after occupational or environmental exposure to known carcinogens.
score: 3.3341667, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Hunt, Jay D et. al.

Absence of p21 expression is associated with abnormal p53 in human breast carcinomas.
score: 3.332581, British journal of cancer, 1997, Ellis, P A et. al.

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
score: 3.3315631, Cancer Cell, 2010, Noushmehr, Houtan et. al.

Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia.
score: 3.3297255, British journal of haematology, 2008, Van Vlierberghe, Pieter et. al.

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer.
score: 3.3296374, British journal of cancer, 2001, Hawkins, N J; Tomlinson, I; Meagher, A; Ward, R L

Analysis of p73 gene in meningiomas with deletion at 1p
score: 3.3288765, Cancer Genetics and Cytogenetics, 2001, Lomas, Jesus et. al.

A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis.
score: 3.3276853, Genes, chromosomes & cancer, 2000, Vaughan, C J et. al.

nm23-H1 expression defines a high-risk subpopulation of patients with early-stage epithelial ovarian carcinoma
score: 3.327364, British Journal of Cancer, 2000, Schneider, J et. al.

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
score: 3.3270242, Nature, 2009, Sanada, Masashi et. al.

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
score: 3.3264825, Cancer Cell, 2005, Weisberg, Ellen et. al.

Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
score: 3.3255999, Nature genetics, 2010, Barretina, Jordi et. al.

Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas.
score: 3.3254897, Cancer research, 1994, Yeh, S H et. al.

Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
score: 3.3249802, British Journal of Cancer, 2009, Jacob, K et. al.

Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells
score: 3.3245501, Cancer Biology & Therapy, 2013, Pires, Maira M. et. al.

Overexpression of leucocyte common antigen (LAR) P-subunit in thyroid carcinomas.
score: 3.3238304, British journal of cancer, 2003, Konishi, N et. al.

PTEN in colorectal cancer: a report on two Cowden syndrome patients.
score: 3.3227642, Clinical genetics, 2012, Kersseboom, R et. al.

Detection of PAX8-PPARG fusion transcripts in archival thyroid carcinoma samples by conventional RT-PCR.
score: 3.3226571, Genes, chromosomes & cancer, 2012, Klemke, Markus et. al.

bcr/abl-Negative, Classic Myeloproliferative Disorders: Diagnosis and Treatment
score: 3.3223816, Mayo Clinic Proceedings, 2005, TEFFERI, AYALEW; BARBUI, TIZIANO

bcr/abl-Negative, Classic Myeloproliferative Disorders: Diagnosis and Treatment
score: 3.3223816, Mayo Clinic Proceedings, 2005, TEFFERI, AYALEW; BARBUI, TIZIANO

Non-Small-Cell Lung Cancer Molecular Signatures Recapitulate Lung Developmental Pathways
score: 3.3221966, The American Journal of Pathology, 2003, Borczuk, Alain C. et. al.

p53 gene point mutations in relation to p53 nuclear protein accumulation in colorectal cancers.
score: 3.3220654, The Journal of pathology, 1995, Costa, A et. al.

p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival.
score: 3.3208223, British journal of cancer, 1996, Barbareschi, M et. al.

Molecular inversion probes: a novel microarray technology and its application in cancer research
score: 3.3207953, Cancer Genetics, 2012, Wang, Yuker; Cottman, MariEllen; Schiffman, Joshua D.

Microfluidic Deletion/Insertion Analysis for Rapid Screening of KIT and PDGFRA Mutations in CD117-Positive Gastrointestinal Stromal Tumors
score: 3.3202844, The Journal of Molecular Diagnostics, 2007, Zamò, Alberto et. al.

Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients.
score: 3.3201748, Molecular carcinogenesis, 2009, Gao, Weimin et. al.

Tumor Suppressor p53 Mutations and Breast Cancer: A Critical Analysis
score: 3.3196743, Advances in Cancer Research, 1995, Ozbun, Michelle A.; Butel, Janet S.

Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell features
score: 3.3185627, Human Pathology, 2012, Setsu, Nokitaka et. al.

Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms.
score: 3.3185382, Cancer research, 1995, Tarmin, L et. al.

BRAF p.Val600Glu (V600E) Testing for Assessment of Treatment Options in Metastatic Colorectal Cancer
score: 3.318243, PLoS Currents, 2010, Lea, Andrew; Allingham-Hawkins, Diane; Levine, Susan

Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.
score: 3.3175843, Oncogene, 1999, Legoix, P et. al.

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?
score: 3.3174724, Angiogenesis, 2009, Gotink, Kristy J.; Verheul, Henk M. W.

Oncogenic potential of BRAF versus RAS
score: 3.3164286, Cancer Letters, 2008, Benjamin, Cara L.; Ananthaswamy, Honnavara N.

Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis
score: 3.3156529, BMC Cancer, 2009, Scartozzi, Mario et. al.

Targeted molecular therapy for cancer: The application of STI571 to gastrointestinal stromal tumor
score: 3.3156093, Current Problems in Surgery, 2003, DeMatteo, Ronald P. et. al.

A genome-wide study of allelic imbalance in human testicular germ cell tumors using microsatellite markers
score: 3.3154337, Cancer Genetics and Cytogenetics, 2006, Bergthorsson, Jon Thor et. al.

The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma
score: 3.3145225, Molecular Cancer, 2009, Gimelli, Stefania et. al.

mRNA and protein expression of p53 mutations in human bladder cancer cell lines
score: 3.3137037, Cancer Letters, 1994, Kawasaki, Takashi et. al.

Nuclear accumulation of p53 in colorectal adenocarcinoma: prognostic importance differs with race and location of the tumor.
score: 3.3128491, Cancer, 1998, Manne, U et. al.

Germline copy number variation and cancer risk
score: 3.3128097, Current Opinion in Genetics & Development, 2010, Kuiper, Roland P et. al.

Angiomyolipoma Have Common Mutations in TSC2 but No Other Common Genetic Events
score: 3.3120381, PLoS ONE, 2011, Qin, Wei et. al.

Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status
score: 3.3100017, British Journal of Cancer, 2008, Akashi, Y et. al.

Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling.
score: 3.3095565, International journal of cancer. Journal international du cancer, 2006, Tews, Bjoern et. al.

Molecular signatures classify astrocytic gliomas by IDH1 mutation status.
score: 3.3081598, International journal of cancer. Journal international du cancer, 2011, Toedt, Grischa et. al.

Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.
score: 3.3075853, Cancer research, 2008, Sawai, Ayana et. al.

MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
score: 3.3075254, Cancer research, 2011, Yoon, Juyong; Koo, Kyoung-Hwa; Choi, Kang-Yell

Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation.
score: 3.3073037, British Journal of Cancer, 1998, Emig, R. et. al.

p53 in prostate cancer: frequent expressed transition mutations.
score: 3.3069921, Journal of the National Cancer Institute, 1994, Chi, S G et. al.

Overexpression of leucocyte common antigen (LAR) P-subunit in thyroid carcinomas
score: 3.3055767, British Journal of Cancer, 2003, Konishi, N et. al.

Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors
score: 3.3052548, Cancer Letters, 2002, Shiao, Yih-Horng et. al.

Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer
score: 3.3047429, FEBS Letters, 2012, Malkoski, Stephen P.; Wang, Xiao-Jing

Snail nuclear expression parallels higher malignancy potential in neuroendocrine lung tumors
score: 3.303242, Lung Cancer, 2010, Galván, J.A. et. al.

Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype
score: 3.299767, Human Pathology, 2007, Ogino, Shuji et. al.

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.
score: 3.2986755, Oncogene, 2001, Ling, G et. al.

Novel germline APC variants in patients with multiple adenomas.
score: 3.2976959, Genes, chromosomes & cancer, 1998, Pedemonte, S et. al.

Renal cell carcinoma
score: 3.2976856, Current Problems in Cancer, 1997, Motzer, Robert J. et. al.

Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer.
score: 3.2958221, Genes, chromosomes & cancer, 2005, Nakano, Tetsuhiro et. al.

Efficient detection of leukemia-related fusion transcripts by multiplex PCR applied on a microelectronic platform.
score: 3.2955816, Leukemia, 2008, Corradi, B et. al.

Somatic NF1 inactivation is a frequent event in sporadic pheochromocytoma.
score: 3.2948485, Human molecular genetics, 2012, Burnichon, Nelly et. al.

Eosinophilic disorders: Molecular pathogenesis, new classification, and modern therapy
score: 3.294788, Best Practice & Research Clinical Haematology, 2006, Gotlib, Jason; Cross, N.C.P.; Gilliland, D. Gary

The genetics of transitional cell carcinoma: progress and potential clinical application.
score: 3.2944556, BJU international, 1999, Knowles, M A

Ras oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids.
score: 3.2943936, Carcinogenesis, 1995, Ferreira-Gonzalez, A; DeAngelo, A B; Nasim, S; Garrett, C T

Classes of c- KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy
score: 3.2941008, Leukemia Research, 2001, Longley, B.Jack; Reguera, Maria Jose; Ma, Yongsheng

Heritability of Hematologic Malignancies: From Pedigrees to Genomics
score: 3.2919988, Hematology/Oncology Clinics of North America, 2010, Churpek, Jane E.; Onel, Kenan

Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer
score: 3.2917472, BMC Cancer, 2009, Mlakar, Vid et. al.

EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases.
score: 3.2913998, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011, Flucke, Uta et. al.

Myelodysplasic syndromes: A comprehensive review
score: 3.2906028, Blood Reviews, 2005, Catenacci, Daniel V.T.; Schiller, Gary J.

Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma.
score: 3.29025, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Thomas, Nancy E et. al.

Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells.
score: 3.2893132, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Bar-Natan, M et. al.

E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions
score: 3.2882179, FEBS Letters, 2012, Carneiro, Patrícia et. al.

Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.
score: 3.2875669, Cancer research, 2005, Brandts, Christian H et. al.

CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas.
score: 3.2875439, Cancer research, 2005, Soung, Young Hwa et. al.

Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
score: 3.287411, BBA - Proteins and Proteomics, 2010, Eck, Michael J.; Yun, Cai-Hong

The candidate tumour suppressor gene, ING1, is retained in colorectal carcinomas
score: 3.286876, European Journal of Cancer, 1999, Sarela, A.I; Farmery, S.M; Markham, A.F; Guillou, P.J

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features.
score: 3.2868554, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Chang, Daniel T et. al.

Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix.
score: 3.2843126, Journal of cellular and molecular medicine, 2009, Willems, Stefan M et. al.

Episodic Src activation in uveal melanoma revealed by kinase activity profiling
score: 3.2837908, British Journal of Cancer, 2009, Maat, W et. al.

Modeling genomic diversity and tumor dependency in malignant melanoma.
score: 3.2837855, Cancer research, 2008, Lin, William M et. al.

Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations
score: 3.2836471, The Journal of Allergy and Clinical Immunology, 2012, Broesby-Olsen, Sigurd et. al.

C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma.
score: 3.2828672, Genes, chromosomes & cancer, 2010, Huang, Dali et. al.

Submandibular synovial sarcoma with t(X;18) and synovial sarcoma of the toe with additional cytogenetic abnormalities:presentation of two cases and review of the literature
score: 3.2805962, Cancer Genetics and Cytogenetics, 2002, Udayakumar, A.M. et. al.

Submandibular synovial sarcoma with t(X;18) and synovial sarcoma of the toe with additional cytogenetic abnormalities
score: 3.2805962, Cancer Genetics and Cytogenetics, 2002, Udayakumar, A.M. et. al.

Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
score: 3.2803994, Molecular pharmacology, 1999, Rajesh, D; Schell, K; Verma, A K

Mutation analysis of p53 in ovarian tumors by DHPLC
score: 3.2803112, Journal of Biochemical and Biophysical Methods, 2001, Gross, Eva; Kiechle, Marion; Arnold, Norbert

Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas.
score: 3.2793587, Cancer research, 1999, Ueki, K; Wen-Bin, C; Narita, Y; Asai, A; Kirino, T

p53 and p21/Waf1 protein expression and K-ras codon 12 mutation in carcinoma of the papilla of Vater.
score: 3.2791065, The American journal of gastroenterology, 1999, Zhao, B et. al.

Effects of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, on human mast cells bearing wild-type or mutated codon 816 c-kit
score: 3.2779641, Leukemia Research, 2006, Verstovsek, Srdan et. al.

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
score: 3.2774972, Cancer research, 2000, Lerman, M I; Minna, J D

Mutations of K-ras oncogene in human adrenal tumours in Taiwan.
score: 3.2771319, British journal of cancer, 1998, Lin, S R; Tsai, J H; Yang, Y C; Lee, S C

A limited role for TP53 mutation in the transformation of follicular lymphoma to diffuse large B-cell lymphoma.
score: 3.276448, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Davies, A J et. al.

Genomic analysis of acute leukemia.
score: 3.2755346, International journal of laboratory hematology, 2009, Mullighan, C G

The biology of Kit in disease and the application of pharmacogenetics
score: 3.2751282, The Journal of Allergy and Clinical Immunology, 2004, Cem Akin, ; Metcalfe, Dean D

Pathogenetic insight and prognostic information from standard and molecular cytogenetic studies in the BCR-ABL-negative myeloproliferative neoplasms (MPNs).
score: 3.2745233, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Reilly, J T

Histopathologic and genetic alterations as predictors of response to treatment and survival in lung cancer: A review of published data
score: 3.273981, Critical Reviews in Oncology and Hematology, 2010, Mountzios, Giannis et. al.

Genome-wide amplification and allelotyping of sporadic pituitary adenomas identify novel regions of genetic loss.
score: 3.2739508, Genes, chromosomes & cancer, 2003, Simpson, D J et. al.

Multiple Leiomyomas of the Esophagus, Lung, and Uterus in Multiple Endocrine Neoplasia Type 1
score: 3.2736919, The American Journal of Pathology, 2001, McKeeby, Jeffrey L. et. al.

Tumours of familial origin in the head and neck
score: 3.2733985, Oral Oncology, 2006, Suárez, Carlos et. al.

Predictive and Prognostic Biomarkers for Targeted Therapy in Metastatic Colorectal Cancer
score: 3.271733, Clinical Colorectal Cancer, 2010, Asghar, Uzma; Hawkes, Eliza; Cunningham, David

CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors.
score: 3.2706627, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Makishima, H et. al.

Relation between smoking history and gene expression profiles in lung adenocarcinomas
score: 3.268756, BMC Medical Genomics, 2012, Staaf, Johan et. al.

Selective RNAi-mediated inhibition of mutated c-kit
score: 3.2687328, Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research, 2009, Ruano, Irene; Izquierdo, Marta

Prognostic role of β-catenin and p53 expression in the metastatic progression of sporadic colorectal cancer
score: 3.2678502, Human Pathology, 2010, Pancione, Massimo et. al.

Is There a Predisposition Gene for Ewing's Sarcoma?
score: 3.2664696, Journal of Oncology, 2010, Randall, R. L. et. al.

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.
score: 3.2662998, Oncogene, 2012, Shi, G et. al.

The marriage of pathology and genetics in soft tissue tumours: EACR—Mühlbock memorial lecture
score: 3.266099, European Journal of Cancer, 1996, Van den Berghe, H.

Roles of p53 mutation in cell line establishment and identification of the minimum transactivation and transform suppression domains
score: 3.2658551, European Journal of Cancer. Part B: Oral Oncology, 1995, Hirano, Y.; Tsutsumi-Ishii, Y.; Tsuchida, N.

Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
score: 3.2657738, Drug Resistance Updates, 2010, Lai, Stephen Y.; Johnson, Faye M.

Targeting ErbB3-mediated stromal–epithelial interactions in pancreatic ductal adenocarcinoma
score: 3.2655599, British Journal of Cancer, 2011, Liles, J S et. al.

p53 gene mutations in skin cancers with underlying disorders
score: 3.2654982, Journal of Dermatological Science, 1995, Kanekura, Takuro et. al.

Absence of microsatellite instability in breast carcinomas with both p53 and c-erbB-2 alterations.
score: 3.2650134, The Journal of pathology, 1999, Formantici, C et. al.

Constitutional Mutations of the hSNF5/INI1 Gene Predispose to a Variety of Cancers
score: 3.2643945, The American Journal of Human Genetics, 1999, Sévenet, Nicolas et. al.

Hyperplastic and Serrated Polyps of the Colorectum
score: 3.2643243, Gastroenterology Clinics of North America, 2007, O'Brien, Michael J.

Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma.
score: 3.2641032, Cancer research, 1992, Höhne, M W; Halatsch, M E; Kahl, G F; Weinel, R J

Mutational analysis of candidate tumor-associated genes in acute megakaryoblastic leukemia.
score: 3.262277, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Bhat, R et. al.

KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies
score: 3.2616496, Lung Cancer, 2010, Mao, Chen et. al.

Molecular characterization of the genomic breakpoint junction in a t(11;22) translocation in Ewing sarcoma.
score: 3.2610482, Genes, chromosomes & cancer, 1999, Obata, K; Hiraga, H; Nojima, T; Yoshida, M C; Abe, S

Oncogenes and cell proliferation
score: 3.2605433, Current Opinion in Genetics & Development, 1995,

A novel germ line juxtamembrane Met mutation in human gastric cancer.
score: 3.2600028, Oncogene, 2000, Lee, J H et. al.

Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient l-amino acid-defined diet in rats
score: 3.2591389, Cancer Letters, 2000, Sasaki, Yasutaka et. al.

Genetic pathways in colorectal and other cancers
score: 3.2577891, European Journal of Cancer, 1999, Ilyas, M.; Straub, J.; Tomlinson, I.P.M.; Bodmer, W.F.

p53 inactivating mutations in Chinese nasopharyngeal carcinomas
score: 3.2576716, Cancer Letters, 1998, Lung, Maria Li et. al.

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.
score: 3.2573432, Cancer research, 1995, Ponce-Castañeda, M V et. al.

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells
score: 3.2570122, Cancer Cell, 2012, Muranen, Taru et. al.

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.
score: 3.2569775, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, da Costa Reis Monte-Mór, B et. al.

FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML
score: 3.2569265, Drug Resistance Updates, 2009, Weisberg, Ellen et. al.

Recent publications in Hematological Oncology.
score: 3.2567562, Hematological oncology, 2006,

From the Bench to Bedside: Biological and Methodology Considerations for the Future of Companion Diagnostics in Nonsmall Cell Lung Cancer
score: 3.2563147, Pathology Research International, 2011, Dimou, Anastasios; Harrington, Kevin; Syrigos, Kostas N.

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53.
score: 3.256151, Oncogene, 1998, Eshleman, J R et. al.

c-Kit and c-kit mutations in mastocytosis and other hematological diseases.
score: 3.2556233, Journal of leukocyte biology, 2000, Boissan, M; Feger, F; Guillosson, J J; Arock, M

t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma
score: 3.254029, Oral Oncology, 2009, O’Neill, Iain D.

A mutation in the p53 tumor suppressor gene of AHH-1 tk + − human lymphoblastoid cells
score: 3.2535739, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1996, Morris, Suzanne M. et. al.

Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas.
score: 3.2531615, Cancer research, 2001, Chen, T et. al.

Gastrointestinal stromal tumors in Iceland, 1990-2003: the icelandic GIST study, a population-based incidence and pathologic risk stratification study.
score: 3.251633, International journal of cancer. Journal international du cancer, 2005, Tryggvason, Geir et. al.

Clinicopathological characteristics of colorectal cancers with loss of imprinting of insulin-like growth factor 2.
score: 3.2488136, International journal of cancer. Journal international du cancer, 2006, Sasaki, Jun-ichi et. al.

Modulated multiparametric phosphoflow cytometry in hematological malignancies: technology and clinical applications
score: 3.2485715, Best Practice & Research Clinical Haematology, 2010, Covey, Todd M.; Cesano, Alessandra

CpG Island Methylation in Aberrant Crypt Foci of the Colorectum
score: 3.2485439, The American Journal of Pathology, 2002, Chan, Annie On-On et. al.

Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates
score: 3.2482551, Human Pathology, 2007, Engels, Knut et. al.

Synovial sarcoma specific translocation associated with both epithelial and spindle cell components.
score: 3.2482334, International journal of cancer. Journal international du cancer, 1999, Birdsall, S; Osin, P; Lu, Y J; Fisher, C; Shipley, J

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.
score: 3.2471689, Cancer research, 1996, Goggins, M et. al.

Putative Tumor Suppressor Loci at 6q22 and 6q23-q24 Are Involved in the Malignant Progression of Sporadic Endocrine Pancreatic Tumors
score: 3.2466911, The American Journal of Pathology, 2001, Barghorn, André et. al.

Targeted antitumour therapy – future perspectives
score: 3.2457577, British Journal of Cancer, 2005, Ranson, M; Jayson, G

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
score: 3.2452656, Journal of Hematology & Oncology, 2012, Gelsi-Boyer, Véronique et. al.

Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.
score: 3.2451295, Cancer research, 2004, Goel, Ajay et. al.

Analysis of the BRCA1 and BRCA2 genes in sporadic meningiomas.
score: 3.2436892, Genes, chromosomes & cancer, 1997, Kirsch, M; Zhu, J J; Black, P M

Screening for germline mutations of the p53 gene in familial breast cancer patients.
score: 3.2395361, European journal of clinical investigation, 1995, Patel, U A; Perry, M; Crane-Robinson, C

High levels of loss at the 17p telomere suggest the close proximity of a tumour suppressor.
score: 3.2393102, British Journal of Cancer, 1996, White, G. R. et. al.

Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies.
score: 3.2373548, Genes, chromosomes & cancer, 2003, Nagai, Hirokazu et. al.

The von Hippel–Lindau Tumor Suppressor Gene
score: 3.2364464, Experimental Cell Research, 2001, Kondo, Keiichi; Kaelin, William G.

Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors.
score: 3.2361399, British journal of cancer, 2005, Weber, F et. al.

Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma
score: 3.2349909, Cancer Letters, 2006, Rutherford, Sue et. al.

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils
score: 3.2337664, EMBO Molecular Medicine, 2011, Torti, Davide; Trusolino, Livio

Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma.
score: 3.2328166, Genes, chromosomes & cancer, 2007, Parikh, Rahul A et. al.

BIALLELIC INACTIVATION OF THE VON HIPPEL-LINDAU TUMOR SUPPRESSOR GENE IN SPORADIC RENAL CELL CARCINOMA
score: 3.2320491, The Journal of Urology, 2002, HAMANO, KIMINARI et. al.

p53 gene aberrations in non-small-cell lung carcinomas from a smoking population.
score: 3.2318181, British Journal of Cancer, 1997, Liloglou, T. et. al.

Mouse models of K- ras-initiated carcinogenesis
score: 3.2317991, BBA - Reviews on Cancer, 2005, Janssen, Klaus-Peter et. al.

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas
score: 3.2300321, PLoS ONE, 2012, Puget, Stephanie et. al.

The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia.
score: 3.2299535, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002, Dyer, M J S; Oscier, D G

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
score: 3.2270177, Cancer research, 1991, Lehman, T A et. al.

P53 mutations and microsatellite analysis of loss of heterozygosity in malignant gliomas
score: 3.2264497, Cancer Genetics and Cytogenetics, 1994, Tenan, Mirna et. al.

Molecular Detection of Von Hippel-Lindau Gene Mutations in Urine and Lymph Node Samples in Patients with Renal Cell Carcinoma: Potential Biomarkers for Early Diagnosis and Postoperative Metastatic Status
score: 3.2259404, The Journal of Urology, 2003, ASHIDA, SHINGO et. al.

K-ras codon 12 mutation determines the polypoid growth of colorectral cancer.
score: 3.2250044, Cancer research, 1998, Chiang, J M; Chou, Y H; Chou, T B

p53 mutations and overexpressions in Japanese breast cancer
score: 3.223908, European Journal of Surgical Oncology, 1995, Fukushima, Toshihiko et. al.

Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.
score: 3.2238768, Pigment cell & melanoma research, 2010, Hyter, Stephen et. al.

Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases.
score: 3.2229782, Cancer research, 2007, Mehra, Rohit et. al.

Coincidental LOH regions in mouse and humans: evidence for novel tumor suppressor loci at 9q22–q34 in non-Hodgkin’s lymphomas
score: 3.2228088, Leukemia Research, 2003, Meléndez, Bárbara et. al.

Targeted therapies in gastrointestinal stromal tumors
score: 3.2225771, Seminars in Diagnostic Pathology, 2008, Antonescu, Cristina R.

Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers.
score: 3.2223135, Anatomical record (Hoboken, N.J. : 2007), 2010, Liao, Wangjun et. al.

Adenomyoepitheliomatous lesions of the mammary glands in transgenic mice with targeted PLAG1 overexpression.
score: 3.2203174, International journal of cancer. Journal international du cancer, 2008, Declercq, Jeroen et. al.

Oncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers
score: 3.218401, Cancer Cell, 2006, Davis, Ian J. et. al.

Subcutaneous undifferentiated sarcoma induced by N′-ethyl-N′-nitrosourea in rat: radiology, histopathology and mutagenesis
score: 3.2158343, Experimental and Toxicologic Pathology, 2003, Özdemir, Öztürk et. al.

Recent advances in diagnosis and treatment of chronic myeloproliferative neoplasms
score: 3.213243, F1000 Medicine Reports, 2010, Guglielmelli, Paola; Vannucchi, Alessandro M

Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors
score: 3.2120565, Human Pathology, 2009, Kim, Yoo Ri; Kim, Kyoung Mee; Yoo, Nam Jin; Lee, Sug Hyung

Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.
score: 3.2110068, Cancer research, 2010, Lazzara, Matthew J et. al.

Molecular genetic analyses in neurofibromatosis type 1 patients with tumors
score: 3.2108349, Cancer Genetics and Cytogenetics, 2006, Oguzkan, Sibel et. al.

Does “clonal progression” relate to the development of intraductal papillary mucinous tumors of the pancreas?
score: 3.2072326, Journal of Gastrointestinal Surgery, 2004, Wada, Keita et. al.

High frequency of genomic instability in Ewing family of tumors
score: 3.2065511, Cancer Genetics and Cytogenetics, 2004, Ohali, Anat et. al.

Genetic changes and DNA damage responses in the prostate.
score: 3.2059896, The Prostate, 2008, Hällström, Taija M Kiviharju-Af; Laiho, Marikki

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.
score: 3.2058477, Nature medicine, 2007, Zhang, Liyong et. al.

Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.
score: 3.2057015, Human mutation, 2009, Kannengiesser, Caroline et. al.

Endometrial and Colorectal Tumors from Patients with Hereditary Nonpolyposis Colon Cancer Display Different Patterns of Microsatellite Instability
score: 3.2048504, The American Journal of Pathology, 2002, Kuismanen, Shannon A. et. al.

Clinical cancer genomics: how soon is now?
score: 3.2040813, The Journal of pathology, 2011, Taylor, Barry S; Ladanyi, Marc

ICSBP promoter methylation in myelodysplastic syndromes and acute myeloid leukaemia.
score: 3.203083, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2011, Otto, N et. al.

Synovial sarcoma of the parotid gland:a case report and review of the literature
score: 3.2015966, Acta Otorhinolaryngologica Italica, 2010, Rigante, M.; Visocchi, M.; Petrone, G.; Mulè, A.; Bussu, F.

FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: a report from the Children's Oncology Group.
score: 3.2013633, Pediatric blood & cancer, 2012, Kutny, Matthew A et. al.

Structural alterations of the p53 gene in human leukemias
score: 3.2010503, Leukemia Research, 1992, Miwa, Hiroshi et. al.

Kinase drug discovery approaches in chronic myeloproliferative disorders.
score: 3.2010195, Oncogene, 2009, Kumar, C; Purandare, A V; Lee, F Y; Lorenzi, M V

The Role of the Adenomatous Polyposis Coli ( Apc) Gene in Human Cancers
score: 3.1996836, Advances in Cancer Research, 1993, Nakamura, Yusuke

Epidermal growth factor receptor abnormalities in lung cancer. Pathogenetic and clinical implications
score: 3.199121, Annals of Diagnostic Pathology, 2006, Prudkin, Ludmila; Wistuba, Ignacio I.

Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
score: 3.1972919, Genes, chromosomes & cancer, 1998, Walker, G J et. al.

Minor Lesion Mutational Spectrum of the Entire NF1 Gene Does Not Explain Its High Mutability but Points to a Functional Domain Upstream of the GAP-Related Domain
score: 3.1964347, The American Journal of Human Genetics, 2000, Fahsold, Raimund et. al.

Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets.
score: 3.1961644, The Journal of pathology, 1999, Garcia, S B; Park, H S; Novelli, M; Wright, N A

Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia.
score: 3.1954327, Cancer research, 1996, Stegmaier, K et. al.

Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer.
score: 3.1951822, Oncogene, 2002, Porter, Timothy R et. al.

Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients
score: 3.1951151, British Journal of Cancer, 2011, Rawson, J B et. al.

Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident.
score: 3.195004, Cancer research, 1999, Yamamoto, S et. al.

Clonal analysis in glioblastoma with epithelial differentiation.
score: 3.1948837, Brain pathology (Zurich, Switzerland), 2001, Mueller, W et. al.

Lymph node reticulum cell neoplasm with progression into cytokeratin-positive interstitial reticulum cell (CIRC) sarcoma: a case study.
score: 3.193498, Histopathology, 2003, Lucioni, M et. al.

Inherited Predisposition to Gastrointestinal Stromal Tumor
score: 3.1931256, Hematology/Oncology Clinics of North America, 2009, Agarwal, Rinki; Robson, Mark

The role of pseudokinases in cancer
score: 3.1928825, Cellular Signalling, 2012, Zhang, Hua et. al.

The role of pseudokinases in cancer
score: 3.1928825, Cellular Signalling, 2012, Zhang, Hua et. al.

Loss of heterozygosity in human skin
score: 3.1921999, Journal of the American Academy of Dermatology, 1999, Happle, Rudolf

Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?
score: 3.1915212, The Journal of investigative dermatology, 2006, Thomas, Nancy E; Berwick, Marianne; Cordeiro-Stone, Marila

No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer.
score: 3.1911586, Molecular carcinogenesis, 2009, Pallier, Karine et. al.

Establishment of a large cell lung cancer cell line (Y-ML-1B) producing granulocyte colony-stimulating factor
score: 3.1908858, Cancer Genetics and Cytogenetics, 2002, Sekido, Yoshitaka et. al.

Oncogene alterations in in vitro transformed rat tracheal epithelial cells
score: 3.1902184, Mutation Research Letters, 1990, Mass, Marc J. et. al.

Chromosome 1 abnormalities in myeloid malignancies: a literature survey and karyotype-phenotype associations.
score: 3.1896019, European journal of haematology, 2010, Caramazza, Domenica et. al.

EGFR Mutations and EGFR Tyrosine Kinase Inhibition in Non–Small Cell Lung Cancer
score: 3.1889332, Seminars in Oncology Nursing, 2008, Miller, Vincent A.

Genomic imbalance in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine.
score: 3.1888939, Molecular carcinogenesis, 2000, Yu, M; Ryu, D Y; Snyderwine, E G

Malignant peripheral nerve sheath tumors with t(X;18). A pathologic and molecular genetic study.
score: 3.1879762, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2000, O'Sullivan, M J et. al.

ETV6 rearrangements are recurrent in myeloid malignancies and are frequently associated with other genetic events.
score: 3.1879756, Genes, chromosomes & cancer, 2012, Haferlach, Claudia et. al.

p53 is frequently mutated in Barrett's metaplasia of the intestinal type.
score: 3.1870726, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Campomenosi, P et. al.

Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients
score: 3.1866406, British Journal of Cancer, 2009, Zlobec, I et. al.

BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins.
score: 3.1864671, Cancer research, 2008, Friday, Bret B et. al.

p53 gene mutation analysis in porokeratosis and porokeratosis-associated squamous cell carcinoma
score: 3.1864118, Journal of Dermatological Science, 1997, Ninomiya, Yoshiro et. al.

Dominant-Negative Mutation of p53 Tumor Suppressor Gene in Endometrial Carcinoma
score: 3.1852401, Gynecologic Oncology, 2001, Sakuragi, Noriaki et. al.

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
score: 3.1846349, International journal of cancer. Journal international du cancer, 2003, Smalley, Keiran S M

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair
score: 3.1842613, Cancer Letters, 2008, Sallmyr, Annahita; Fan, Jinshui; Rassool, Feyruz Virgilia

Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies.
score: 3.1839154, British journal of haematology, 2004, Bench, Anthony J et. al.

Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes
score: 3.1835528, The Lancet, 2010, Krug, Utz et. al.

THYROID CARCINOMA-ASSOCIATED GENETIC MUTATIONS ALSO OCCUR IN THYROID LYMPHOMAS
score: 3.1822548, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Aggarwal, Nidhi et. al.

Immunohistochemical analysis of phosphorylated epidermal growth factor receptor might provide a surrogate marker of EGFR mutation
score: 3.1810323, Lung Cancer, 2009, Endoh, Hideki et. al.

An immature immunophenotype of bone marrow mast cells predicts for multilineage D816V KIT mutation in systemic mastocytosis.
score: 3.1797078, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Teodosio, C et. al.

Mutation of the uracil DNA glycosylase gene detected in glioblastoma
score: 3.1795988, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998, Moon, Young-Wan et. al.

Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
score: 3.1791843, European Journal of Cancer, 2012, Italiano, Antoine et. al.

Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
score: 3.1791843, European Journal of Cancer, 2012, Italiano, Antoine et. al.

Cystic neoplasms of the exocrine pancreas.
score: 3.1789593, Histopathology, 2008, Campbell, F; Azadeh, B

Reply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
score: 3.1787249, Cancer Letters, 2005, Lima, Jorge et. al.

Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.
score: 3.1785283, Molecular carcinogenesis, 1996, Walker, C; Ahn, Y T; Everitt, J; Yuan, X

Receptor tyrosine kinases in normal and malignant haematopoiesis
score: 3.1781798, Blood Reviews, 2003, Reilly, John T

Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.
score: 3.1768666, Oncogene, 2005, Soung, Young Hwa et. al.

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
score: 3.1761559, Cancer research, 2009, Ihle, Nathan T et. al.

FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells.
score: 3.1759445, British journal of cancer, 2003, Sturla, L-M; Merrick, A E; Burchill, S A

An Intron-Derived Insertion/Truncation Mutation in the BCR-ABL Kinase Domain in Chronic Myeloid Leukemia Patients Undergoing Kinase Inhibitor Therapy
score: 3.1750077, The Journal of Molecular Diagnostics, 2008, Laudadio, Jennifer et. al.

Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas.
score: 3.1747936, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Salahshor, Sima et. al.

BRG1 loss in MiaPaCa2 cells induces an altered cellular morphology and disruption in the organization of the actin cytoskeleton.
score: 3.1746983, Journal of cellular physiology, 2005, Rosson, Gary B et. al.

Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, Greece.
score: 3.1740856, Histopathology, 2006, Campo, E et. al.

Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition
score: 3.1740204, Pharmacological Research, 2013, Roskoski, Robert

Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes
score: 3.1737689, Gastroenterology, 1993, Chastre, Eric et. al.

Histotype-specific copy-number alterations in ovarian cancer
score: 3.1721465, BMC Medical Genomics, 2012, Huang, Ruby YunJu et. al.

L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer
score: 3.1721389, Lung Cancer, 2006, Sasaki, Hidefumi et. al.

Mitochondrial DNA Somatic Mutations (Point Mutations and Large Deletions) and Mitochondrial DNA Variants in Human Thyroid Pathology
score: 3.1714883, The American Journal of Pathology, 2002, Máximo, Valdemar et. al.

JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade, Providing a Rationale for Co-targeting these Pathways in Metastatic Breast Cancer
score: 3.171191, Cancer Cell, 2012, Britschgi, Adrian et. al.

Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications
score: 3.1711691, Surgical Oncology, 2001, Magee, Conor J et. al.

Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias
score: 3.1711055, Leukemia Research, 2001, Hofmann, Wolf-K. et. al.

Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer
score: 3.1704309, British Journal of Cancer, 2010, Mori, N et. al.

SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
score: 3.1699092, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2009, Nosho, Katsuhiko et. al.

Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
score: 3.1689555, Molecular and cellular biology, 1990, Cheng, J; Haas, M

Loss of Heterozygosity of the Retinoblastoma and p53 Genes in Primary Cervical Carcinomas with Human Papillomavirus Infection
score: 3.1685058, Gynecologic Oncology, 1997, Kim, Jin Woo et. al.

Recent advances in bone marrow biopsy pathology
score: 3.1674959, Journal of Hematopathology, 2009, van der Walt, Jon

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.
score: 3.167294, Cancer research, 1995, Herman, J G et. al.

Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation.
score: 3.1669028, International journal of cancer. Journal international du cancer, 2008, Ahmed, Mansoor M et. al.

p53 mutational spectrum of esophageal carcinomas from five different geographical locales in China.
score: 3.1663145, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Lung, M L et. al.

Novel Germline Mutation of KIT Associated With Familial Gastrointestinal Stromal Tumors and Mastocytosis
score: 3.166283, Gastroenterology, 2005, Hartmann, Karin et. al.

Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.
score: 3.1657223, Proceedings of the National Academy of Sciences of the United States of America, 1992, Makino, H et. al.

Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer.
score: 3.1647519, Oncogene, 2004, Bartkova, Jirina et. al.

MAPK pathway activation in pilocytic astrocytoma
score: 3.1639595, Cellular and Molecular Life Sciences, 2011, Jones, David T. W. et. al.

The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications
score: 3.1637092, Critical Reviews in Oncology and Hematology, 2003, Asou, Norio

PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors.
score: 3.1626668, Molecular cancer therapeutics, 2011, Janku, Filip et. al.

Thyroid carcinoma: molecular pathways and therapeutic targets.
score: 3.1623962, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Nikiforov, Yuri E

Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.
score: 3.160476, Cancer research, 2002, Tong, Wei-Min et. al.

Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder.
score: 3.157766, British journal of cancer, 2001, Kimura, F et. al.

Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts.
score: 3.1566654, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2001, Birkenkamp, K U et. al.

Quantification of subclonal distributions of recurrent genomic aberrations in paired pre-treatment and relapse samples from patients with B-cell chronic lymphocytic leukemia.
score: 3.1565645, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Knight, S J L et. al.

Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia.
score: 3.1561889, British journal of cancer, 2011, Hou, H-A et. al.

Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors.
score: 3.1554278, Cancer research, 1994, Herzog, C R; Wiseman, R W; You, M

Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.
score: 3.1554077, Cancer research, 1992, Jung, M; Notario, V; Dritschilo, A

Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice.
score: 3.1547803, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Guerrero, Sílvia et. al.

Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation.
score: 3.1541057, Oncogene, 2010, Zuntini, M et. al.

ARID2: A new tumor suppressor gene in hepatocellular carcinoma
score: 3.1537273, Oncotarget, 2011, Zhao, Hong et. al.

Gastrointestinal stromal tumors
score: 3.152508, International Journal of Colorectal Disease, 2011, Beham, Alexander W. et. al.

Genetic and Pharmacologic Dissection of Ras Effector Utilization in Oncogenesis
score: 3.1497392, Methods in Enzymology, 2006, Campbell, Paul M. et. al.

Genetic and Pharmacologic Dissection of Ras Effector Utilization in Oncogenesis
score: 3.1497392, Methods in Enzymology, 2006, Campbell, Paul M. et. al.

Signatures of Selection in Fusion Transcripts Resulting From Chromosomal Translocations in Human Cancer
score: 3.149322, PLoS ONE, 2009, Ortiz de Mendíbil, Iñigo et. al.

Frequent genomic imbalances suggest commonly altered tumour genes in human hepatocarcinogenesis.
score: 3.1492885, British journal of cancer, 2001, Niketeghad, F et. al.

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.
score: 3.1485681, EMBO molecular medicine, 2010, Cole, Alicia M et. al.

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function.
score: 3.1476589, Oncogene, 1997, Cai, Z et. al.

Correlation of enhanced cell turnover with prognosis of gastrointestinal stromal tumors of the stomach: relevance of cellularity and p27kip1.
score: 3.1476061, Pathology international, 2006, Nemoto, Yuta et. al.

p53 alterations in chemically induced hamster cheek-pouch lesions.
score: 3.1464821, Molecular carcinogenesis, 1996, Gimenez-Conti, I B; LaBate, M; Liu, F; Osterndorff, E

Meeting report: Seventh International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, MD, May 13–16, 2007
score: 3.146306, Experimental Hematology, 2008, Wolff, Linda; Ackerman, Steven J.; Nucifora, Giuseppina

Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.
score: 3.1456187, Oncogene, 2007, Tomlinson, D C; Hurst, C D; Knowles, M A

Long-term survival and transmission of INI1-mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome.
score: 3.1452127, British journal of cancer, 2008, Ammerlaan, A C J et. al.

Chromosomal copy number alterations are associated with tumor response to chemoradiation in locally advanced rectal cancer.
score: 3.1440851, Genes, chromosomes & cancer, 2011, Chen, Zhenbin et. al.

The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: An overview with emphasis on the myeloid neoplasms
score: 3.1434868, Chemico-Biological Interactions, 2010, Vardiman, James W.

Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française.
score: 3.1427173, Annals of neurology, 1999, Zhou, X P et. al.

p53 alterations in human leukemia-lymphoma cell lines: in vitroartifact or prerequisite for cell immortalization?
score: 3.1427106, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2000, Drexler, H G et. al.

Database and software for the analysis of mutations in the human p53 gene.
score: 3.1426467, Cancer research, 1994, Cariello, N F; Cui, L; Beroud, C; Soussi, T

New targets for therapy in acute myeloid leukemia.
score: 3.141212, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2003, Appelbaum, F R

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia.
score: 3.1405298, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Tyner, J W et. al.

Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain
score: 3.1399664, Molecular Cancer, 2007, de Gunst, Matheus M et. al.

Chromosomal losses of regions on 5q and lack of high-level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma.
score: 3.1399013, Genes, chromosomes & cancer, 2006, Staebler, Annette et. al.

Gene expression signatures of morphologically normal breast tissue identify basal-like tumors
score: 3.1392043, Breast Cancer Research, 2006, Finak, Greg et. al.

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.
score: 3.1381882, Proceedings of the National Academy of Sciences of the United States of America, 1992, Sun, Y et. al.

No evidence of frequent association of the JAK2 V617F mutation with acute myocardial infarction in young patients.
score: 3.1374221, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Politou, M et. al.

The use of first-generation tyrosine kinase inhibitors in patients with NSCLC and somatic EGFR mutations
score: 3.1374108, Lung Cancer, 2008, Riely, Gregory J.

Transcriptional Profiling of Non-Small Cell Lung Cancer Cells with Activating EGFR Somatic Mutations
score: 3.1354051, PLoS ONE, 2007, Choi, Kuicheon et. al.

Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes
score: 3.1344519, BMC Cancer, 2013, Ninomiya, Hironori et. al.

Pharmacogenetics and biomarkers in colorectal cancer.
score: 3.1334201, The pharmacogenomics journal, 2009, Strimpakos, A S; Syrigos, K N; Saif, M W

Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome
score: 3.1330733, Leukemia Research, 2007, Bogdanović, Gordana et. al.

Recent Advances in Thyroid Cancer
score: 3.1328909, Current Problems in Surgery, 2008, Grubbs, Elizabeth G. et. al.

Molecular analysis of the EGFR gene in astrocytic gliomas: mRNA expression, quantitative-PCR analysis of non-homogeneous gene amplification and DNA sequence alterations.
score: 3.1298501, Neuropathology and applied neurobiology, 2005, Arjona, D et. al.

Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma.
score: 3.1284616, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Nagel, S et. al.

Acquired Robertsonian translocations are not rare events in acute leukemia and lymphoma
score: 3.128447, Cancer Genetics and Cytogenetics, 2004, Welborn, Jeanna

Pharmacogenomics in non-small-cell lung cancer chemotherapy
score: 3.1282063, Advanced Drug Delivery Reviews, 2009, Danesi, Romano et. al.

Genetic and epigenetic alteration profiles for multiple genes in salivary gland carcinomas
score: 3.1262421, Oral Oncology, 2005, Kishi, Munehiro et. al.

Polycythemia vera transforming to acute myeloid leukemia and complex abnormalities including 9p homogeneously staining region with amplification of MLLT3, JMJD2C, JAK2, and SMARCA2
score: 3.1261003, Cancer Genetics and Cytogenetics, 2008, Hélias, Catherine et. al.

Molecular characterization of jumping translocations reveals spatial and temporal breakpoint heterogeneity.
score: 3.1248015, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1998, Andreasson, P et. al.

Detection of mutations in the p53 gene in human head and neck carinomas by single strand conformation polymorphism analysis
score: 3.1235678, Cancer Letters, 1992, Chang, Yu-Sun et. al.

Early Growth Response-1 Induces and Enhances Vascular Endothelial Growth Factor-A Expression in Lung Cancer Cells
score: 3.1231987, The American Journal of Pathology, 2010, Shimoyamada, Hiroaki et. al.

Integration of Next-Generation Sequencing Into Clinical Practice: Are We There Yet?
score: 3.1231353, Seminars in Oncology, 2012, Kohlmann, Alexander; Grossmann, Vera; Haferlach, Torsten

Text-based analysis of genes, proteins, aging, and cancer
score: 3.1221335, Mechanisms of Ageing and Development, 2005, Semeiks, Jeremy R.; Grate, L.R.; Mian, I.S.

Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
score: 3.1220575, British Journal of Cancer, 2005, Weber, F et. al.

The eosinophilias, including the idiopathic hypereosinophilic syndrome.
score: 3.1216316, British journal of haematology, 2003, Brito-Babapulle, Finella

11q21.1-11q23.3 Is a site of intrinsic genomic instability triggered by irradiation.
score: 3.1211515, Genes, chromosomes & cancer, 2010, Du, Nga et. al.

Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by Flow Cytometry Is Associated WithNPM1andFLT3Mutation Status in Cytogenetically Normal Acute Myeloid Leukemia
score: 3.1209237, Clinical Lymphoma Myeloma and Leukemia, 2012, Dalal, Bakul I. et. al.

Constitutional trisomy 8 mosaicism in primary myelofibrosis: relevance to clinical practice and warning for trisomy 8 studies
score: 3.1206091, Cancer Genetics and Cytogenetics, 2007, Maserati, Emanuela et. al.

Microarray analysis refines classification of non-medullary thyroid tumours of uncertain malignancy.
score: 3.1192817, Oncogene, 2008, Fontaine, J-F et. al.

Deep intronic point mutations of the KIT gene in a female patient with cutaneous clear cell sarcoma and her family
score: 3.1191331, Cancer Genetics, 2012, Gambichler, Thilo et. al.

Deep intronic point mutations of the KIT gene in a female patient with cutaneous clear cell sarcoma and her family
score: 3.1191331, Cancer Genetics, 2012, Gambichler, Thilo et. al.

Molecular features of thyroid oncocytic tumors
score: 3.1183003, Molecular and Cellular Endocrinology, 2010, Gasparre, Giuseppe et. al.

BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
score: 3.1177398, Molecular Cancer, 2011, Makrodouli, Eleni et. al.

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.
score: 3.1176334, Oncogene, 2011, Yang, D et. al.

High frequency of MYH gene mutations in a subset of patients with familial adenomatous polyposis
score: 3.1175247, Gastroenterology, 2004, Venesio, Tiziana et. al.

Wnt signaling pathways in urological cancers: past decades and still growing
score: 3.1172201, Molecular Cancer, 2012, Majid, Shahana; Saini, Sharanjot; Dahiya, Rajvir

Apoptosis In Targeted Therapy Responses-Chapter Sixteen:The Role of BIM
score: 3.1156179, Advances in Pharmacology, 2012, Faber, Anthony C. et. al.

Detection of Mutated K12- ras in Histologically Negative Lymph Nodes as an Indicator of Poor Prognosis in Stage II Colorectal Cancer
score: 3.1153063, Clinical Colorectal Cancer, 2001, Belly, Robert T. et. al.

Microsatellite instability of selective target genes in HNPCC-associated colon adenomas.
score: 3.1152532, Oncogene, 2005, Woerner, Stefan M et. al.

Chronic myelogenous leukemia as a paradigm of early cancer and possible curative strategies.
score: 3.114617, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2003, Clarkson, B; Strife, A; Wisniewski, D; Lambek, C L; Liu, C

A subset of cranial fasciitis is associated with dysregulation of the Wnt/beta-catenin pathway.
score: 3.1145264, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Rakheja, Dinesh et. al.

Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L
score: 3.1143873, Lung Cancer, 2006, Asahina, Hajime et. al.

Mutations of the epidermal growth factor receptor in non-small cell lung cancer – Search and destroy
score: 3.1141656, European Journal of Cancer, 2006, Chan, S.K.; Gullick, W.J.; Hill, M.E.

Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.
score: 3.1129197, British journal of cancer, 2011, Rachagani, S et. al.

Molecular Diagnostic Approach to Non-Hodgkin's Lymphoma
score: 3.1128781, The Journal of Molecular Diagnostics, 2000, Arber, Daniel A.

The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion.
score: 3.1126729, The Journal of pathology, 2006, Verhagen, P C M S et. al.

The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Therapy of Acute Myelogenous Leukemia in Adults: An Evidence-Based Review
score: 3.1119789, Biology of Blood and Marrow Transplantation, 2008, Oliansky, Denise M. et. al.

Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease
score: 3.1119345, Gastroenterology, 1998, Chi, Sung-Gil et. al.

Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma
score: 3.1104581, European Journal of Cancer. Part B: Oral Oncology, 1995, Qian, Wang et. al.

Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors.
score: 3.1092832, Cancer research, 1997, Souza, R F et. al.

Management of malignant gastrointestinal stromal tumours
score: 3.1084661, Lancet Oncology, 2002, Joensuu, Heikki et. al.

PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease
score: 3.1071471, Cancer Cell, 2003, Cools, Jan et. al.

Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation-specific antibody and direct sequencing
score: 3.107041, Leukemia Research, 2010, Andrulis, Mindaugas et. al.

Phase I study of cladribine, cytarabine (Ara-C), granulocyte colony stimulating factor (G-CSF) (CLAG Regimen) and simultaneous escalating doses of imatinib mesylate (Gleevec) in relapsed/refractory AML
score: 3.1052924, Leukemia Research, 2008, Walker, Alison R. et. al.

MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone.
score: 3.1051819, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011, Dujardin, Fanny et. al.

Epidermal Growth Factor Receptor Inhibitors: Current Status and Future Directions
score: 3.1046962, Current Problems in Cancer, 2009, Chen, Helen X. et. al.

The history of myeloproliferative disorders: before and after Dameshek.
score: 3.1038254, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Tefferi, A

Intronic sequence variants of the CDKN2A gene in melanoma pedigrees.
score: 3.10348, Genes, chromosomes & cancer, 2005, Harland, Mark et. al.

Cloning of the human phospholipase A2 activating protein ( hPLAP) gene on the chromosome 9p21 melanoma deleted region
score: 3.1020812, Gene, 1999, Ruiz, Anna; Nadal, Marga; Puig, Susana; Estivill, Xavier

Down-Regulation of DUSP6 Expression in Lung Cancer
score: 3.1008549, The American Journal of Pathology, 2009, Okudela, Koji et. al.

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer.
score: 3.1003805, Cancer, 2011, Tran, Ben et. al.

Cigarette smoking, von Hippel–Lindau gene mutations and sporadic renal cell carcinoma
score: 3.1002315, British Journal of Cancer, 2006, van Dijk, B A C et. al.

Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
score: 3.0989677, Cancer research, 1996, Kawajiri, K; Eguchi, H; Nakachi, K; Sekiya, T; Yamamoto, M

K-ras mutations and RASSF1A promoter methylation in colorectal cancer.
score: 3.0985557, Oncogene, 2002, van Engeland, Manon et. al.

The Wnt signaling pathway in solid childhood tumors
score: 3.0982556, Cancer Letters, 2003, Koesters, Robert; Doeberitz, Magnus von Knebel

Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.
score: 3.0980666, British journal of haematology, 2006, Grandage, Victoria L et. al.

Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol
score: 3.0975805, International Journal of Hematology, 2008, Wakui, Moe et. al.

Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer
score: 3.0974276, European Journal of Cancer, 2012, Lochhead, Paul et. al.

Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer
score: 3.0974276, European Journal of Cancer, 2012, Lochhead, Paul et. al.

p53 mutation and epidermal growth factor receptor overexpression in glioblastoma.
score: 3.0965645, Journal of Korean Medical Science, 2001, Yoon, K. S. et. al.

Mutation of the 9q34 gene TSC1 in sporadic bladder cancer.
score: 3.0959986, Oncogene, 1999, Hornigold, N et. al.

Low frequency of somatic mutations in the FH /multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
score: 3.0951085, British Journal of Cancer, 2002, Barker, K T et. al.

KRAS Mutations Testing in Colorectal Carcinoma Patients in Italy: From Guidelines to External Quality Assessment
score: 3.0945377, PLoS ONE, 2011, Normanno, Nicola et. al.

Chronic Myeloproliferative Neoplasms: a Collaborative Approach
score: 3.0940727, Mediterranean Journal of Hematology and Infectious Diseases, 2010, Pieri, Lisa; Guglielmelli, Paola; Vannucchi, Alessandro M.

K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junction.
score: 3.0935584, Journal of gastroenterology and hepatology, 2000, Lord, R V; O'Grady, R; Sheehan, C; Field, A F; Ward, R L

Detection of Exon 12 Mutations in the JAK2 Gene
score: 3.0929232, The Journal of Molecular Diagnostics, 2010, Laughlin, Todd S. et. al.

Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
score: 3.0922779, Molecular Cancer, 2010, Baba, Yoshifumi et. al.

Other Targetable Sarcomas
score: 3.0921471, Seminars in Oncology, 2009, Pires de Camargo, Veridiana et. al.

Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation
score: 3.0914931, Gastroenterology, 2004, Gallinger, Steven et. al.

BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells.
score: 3.091191, Molecular cancer research : MCR, 2008, Sala, Elisa et. al.

Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down's syndrome.
score: 3.0909099, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Klusmann, J H et. al.

Cytogenetics and Molecular Genetics of Bone and Soft Tissue Tumors
score: 3.08961, Advances in Cancer Research, 1996, Mandahl, Nils

Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation.
score: 3.0890617, British journal of cancer, 1998, Emig, R et. al.

Drug Targeting of Oncogenic Pathways in Melanoma
score: 3.0890041, Hematology/Oncology Clinics of North America, 2009, Fecher, Leslie A. et. al.

Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in breast carcinomas in vivo.
score: 3.0884982, British Journal of Cancer, 1998, Barker, K. T.; Crompton, M. R.

Prognostic utility of BRAF mutation in papillary thyroid cancer
score: 3.0877286, Molecular and Cellular Endocrinology, 2010, Xing, Mingzhao

Deregulated Ras signaling in developmental disorders: new tricks for an old dog
score: 3.0874967, Current Opinion in Genetics & Development, 2007, Schubbert, Suzanne; Bollag, Gideon; Shannon, Kevin

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
score: 3.0873357, Breast Cancer Research, 2003, Alkarain, Angel; Slingerland, Joyce

Expression of the adaptor protein Lnk in leukemia cells
score: 3.0871283, Experimental Hematology, 2009, Gery, Sigal et. al.

Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.
score: 3.0870449, Oncogene, 2006, Vitagliano, D et. al.

MULTIPLE ENDOCRINE NEOPLASIA TYPE 1
score: 3.0866759, Endocrinology and Metabolism Clinics of North America, 2000, Thakker, Rajesh V.

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.
score: 3.0863864, Leukemia, 2011, Hart, S et. al.

Laterally Spreading Type of Colorectal Adenoma Exhibits a Unique Methylation Phenotype and K-ras Mutations
score: 3.0859567, Gastroenterology, 2006, Hiraoka, Sakiko et. al.

Continued treatment with gefitinib beyond progressive disease benefits patients with activating EGFR mutations
score: 3.0846323, Lung Cancer, 2013, Asami, Kazuhiro et. al.

5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
score: 3.0841961, British journal of cancer, 2010, Bracht, K; Nicholls, A M; Liu, Y; Bodmer, W F

The therapy of relapsed acute leukaemia in adults
score: 3.0834783, Blood Reviews, 2004, Litzow, Mark R

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas.
score: 3.0834242, British journal of cancer, 2002, Barker, K T et. al.

Lipid Rafts and Caveolae in Signaling by Growth Factor Receptors
score: 3.0833906, The Open Biochemistry Journal, 2007, de Laurentiis, Angela; Donovan, Lorna; Arcaro, Alexandre

DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer.
score: 3.0828084, British journal of cancer, 2011, Cui, T et. al.

Tissue Microarray Validation of Epidermal Growth Factor Receptor and SALL2 in Synovial Sarcoma with Comparison to Tumors of Similar Histology
score: 3.0817818, The American Journal of Pathology, 2003, Nielsen, Torsten O. et. al.

MmTRA1b/phospholipid scramblase 1 gene expression is a new prognostic factor for acute myelogenous leukemia
score: 3.0814216, Leukemia Research, 2004, Yokoyama, Akihiro et. al.

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
score: 3.0808138, Cancer Cell, 2006, Derksen, Patrick W.B. et. al.

DNA sequencing of a cytogenetically normal acute myeloid leukemia genome
score: 3.0807823, Nature, 2008, Ley, Timothy J et. al.

Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications.
score: 3.080441, Cancer, 1998, Lleonart, M E et. al.

Molecular cytogenetics as a clinical test for prognostic and predictive biomarkers in newly diagnosed ovarian cancer
score: 3.0802215, Journal of Ovarian Research, 2013, Gunn, Shelly et. al.

Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer.
score: 3.080138, British journal of cancer, 2012, Pichler, M et. al.

Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes
score: 3.0794481, Cancer Causes & Control , 2007, Weijenberg, Matty P. et. al.

Chromosomal aberrations and microsatellite instability of malignant peripheral nerve sheath tumors: a study of 10 tumors from nine patients
score: 3.079164, Cancer Genetics and Cytogenetics, 2006, Kobayashi, Chikashi et. al.

Genetic Progression and Divergence in Pancreatic Carcinoma
score: 3.0790397, The American Journal of Pathology, 2000, Yamano, Miki et. al.

Analysis of microsatellite alterations in gastric carcinoma using the crypt isolation technique.
score: 3.0787608, The Journal of pathology, 2004, Jiao, Yu-Fei et. al.

Hyperplastic Polyps and Sessile Serrated Adenomas as a Phenotypic Expression of MYH-Associated Polyposis
score: 3.0766091, Gastroenterology, 2008, Boparai, Karam S. et. al.

EWS–ETS oncoproteins: The linchpins of Ewing tumors
score: 3.0761918, Gene, 2005, Janknecht, Ralf

Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas.
score: 3.075931, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Falini, B et. al.

Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit
score: 3.0749983, Experimental Hematology, 2003, Akin, Cem et. al.

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils.
score: 3.0739863, EMBO molecular medicine, 2011, Torti, Davide; Trusolino, Livio

A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia
score: 3.0738668, Cancer Genetics and Cytogenetics, 2004, Lazarevic̀, Vladimir Lj. et. al.

Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization.
score: 3.0734726, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2004, Althof, Pamela A et. al.

Expression of the DCC gene in myelodysplastic syndromes and overt leukemia
score: 3.0728741, Leukemia Research, 1993, Miyake, Koichi; Inokuchi, Koiti; Dan, Kazuo; Nomura, Takeo

Regional mapping of suppressor loci for anchorage independence and tumorigenicity on human chromosome 9
score: 3.072491, Cancer Genetics and Cytogenetics, 2001, Eklund, Lena K. et. al.

Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder
score: 3.0720711, British Journal of Cancer, 2001, Kimura, F et. al.

Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma.
score: 3.0716372, Journal of surgical oncology, 1998, Rijken, A M et. al.

Association of minisatellite instability with c-myc amplification and K-ras mutation in methylcholanthrene-induced mouse sarcomas.
score: 3.071103, Cancer research, 1995, Niwa, O et. al.

Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients.
score: 3.0708767, Genes, chromosomes & cancer, 1999, Friedl, W et. al.

Cryptic chromosome rearrangement resulting in SYT-SSX2 fusion gene in a monophasic synovial sarcoma
score: 3.0690842, Cancer Genetics and Cytogenetics, 2008, Torres, Lurdes et. al.

Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma.
score: 3.0690767, Oncogene, 2008, Ferreira, B I et. al.

Loss of heterozygosity of tumour suppressor gene loci in human colorectal carcinoma
score: 3.0677685, European Journal of Cancer, 1994, Iacopetta, B. et. al.

AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes.
score: 3.0667722, Genes, chromosomes & cancer, 2005, Haferlach, Torsten et. al.

Essential Thrombocythemia Beyond the First Decade: Life Expectancy, Long-term Complication Rates, and Prognostic Factors
score: 3.0665595, Mayo Clinic Proceedings, 2006, Wolanskyj, Alexandra P. et. al.

Essential Thrombocythemia Beyond the First Decade: Life Expectancy, Long-term Complication Rates, and Prognostic Factors
score: 3.0665595, Mayo Clinic Proceedings, 2006, Wolanskyj, Alexandra P. et. al.

Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.
score: 3.0658662, Cancer research, 1993, Thorlacius, S; Börresen, A L; Eyfjörd, J E

p53 Mutation analysis in breast tumors by a DNA microarray method.
score: 3.0655035, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Tennis, Meredith et. al.

Hyperéosinophilies et affections hématologiques
score: 3.0653164, La Revue de médecine interne, 2009, Malfuson, J.-V. et. al.

Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients.
score: 3.0652776, British journal of cancer, 2010, Zlobec, I et. al.

Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors.
score: 3.0646888, International journal of cancer. Journal international du cancer, 2008, Arnold, Christian N et. al.

Laser pressure catapulting (LPC): optimization LPC-system and genotyping of colorectal carcinomas.
score: 3.0646219, Journal of cellular physiology, 2005, Bazan, Viviana et. al.

E-cadherin and β-catenin expression in early stage cervical carcinoma: a tissue microarray study of 147 cases
score: 3.0641124, World Journal of Surgical Oncology, 2005, Fadare, Oluwole et. al.

Frequent genomic imbalances suggest commonly altered tumour genes in human hepatocarcinogenesis
score: 3.0635936, British Journal of Cancer, 2001, Niketeghad, F et. al.

8p11 myeloproliferative syndrome: a review
score: 3.0602354, Human Pathology, 2010, Jackson, Courtney C. et. al.

Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML.
score: 3.0596676, Genes, chromosomes & cancer, 2011, Rücker, Frank G et. al.

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.
score: 3.0596267, Oncogene, 1999, Handschuh, G et. al.

Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers.
score: 3.0594523, Cancer research, 2000, Sarkar, S et. al.

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.
score: 3.0593336, Nature genetics, 2011, March, H Nikki et. al.

Genomic gain of the epidermal growth factor receptor harboring band 7p12 is part of a complex pattern of genomic imbalances in oral squamous cell carcinomas
score: 3.0579992, Archives of Medical Research, 2004, Gebhart, Erich et. al.

Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm.
score: 3.057861, American journal of hematology, 2011, Rumi, Elisa et. al.

Soft Tissue and Bone Sarcoma Group, 25th Anniversary Meeting on Sarcomas, April 5–7, 2001, Aarhus, Denmark
score: 3.0568288, Sarcoma, 2001, Gibbs, John

Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer.
score: 3.0567565, British journal of cancer, 2009, Chua, W et. al.

Relative quantitation of p53 and MDM2 gene expression in leiomyosarcoma; real-time semi-quantitative reverse transcription-polymerase chain reaction
score: 3.0567394, Cancer Letters, 2001, Miyajima, Kimitaka et. al.

Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues
score: 3.0552612, Analytical Biochemistry, 2009, Dufort, Sandrine et. al.

Cytogenetic Characterization of 22 Human Renal Cell Tumors in Relation to a Histopathological Classification
score: 3.054643, Cancer Genetics and Cytogenetics, 1999, Verdorfer, Irmgard et. al.

Coexistence of K-ras mutations and HPV infection in colon cancer
score: 3.054509, BMC Cancer, 2006, Buyru, Nur; Tezol, Ayda; Dalay, Nejat

Sequence and Structure Signatures of Cancer Mutation Hotspots in Protein Kinases
score: 3.0533564, PLoS ONE, 2009, Dixit, Anshuman et. al.

Myelodysplastic syndrome and associated skin lesions: a review of the literature
score: 3.0532619, Leukemia Research, 1999, Avivi, Irit; Rosenbaum, Hanna; Levy, Yishai; Rowe, Jacob

Similarities and Differences Between Therapy-Related and Elderly Acute Myeloid Leukemia
score: 3.0529081, Mediterranean Journal of Hematology and Infectious Diseases, 2011, D’Alò, Francesco et. al.

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium
score: 3.0511641, EMBO Molecular Medicine, 2010, Cole, Alicia M et. al.

Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9
score: 3.0505996, Cell, 1992, Gailani, Mae R. et. al.

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
score: 3.0497185, Cancer Cell, 2002, Weisberg, Ellen et. al.

Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management.
score: 3.0482317, American journal of hematology, 2012, Estey, Elihu H

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways.
score: 3.0454412, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Grandage, V L; Gale, R E; Linch, D C; Khwaja, A

Loss of heterozygosity reveals non- VHL allelic loss in hemangioblastomas at 22q13
score: 3.0452199, Human Pathology, 2004, Beckner, Marie E. et. al.

Replication error-type genetic instability at 1q42-43 in human male germ cell tumors.
score: 3.0450576, Cancer research, 1994, Murty, V V et. al.

Epigenetic therapy in myeloproliferative neoplasms: evidence and perspectives.
score: 3.0438183, Journal of cellular and molecular medicine, 2009, Vannucchi, Alessandro M et. al.

Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias
score: 3.0423925, Lancet Oncology, 2003, Gambacorti-Passerini, Carlo B et. al.

Controversies and Open Questions in the Definitions and Classification of the Hypereosinophilic Syndromes and Eosinophilic Leukemias
score: 3.0420103, Seminars in Hematology, 2012, Valent, Peter et. al.

Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders.
score: 3.0416846, European journal of human genetics : EJHG, 2002, van Rhijn, Bas W G et. al.

Mutations in the ST7/RAY1/HELG locus rarely occur in primary colorectal, gastric, and hepatocellular carcinomas.
score: 3.0411127, British journal of cancer, 2003, Yoshimura, S et. al.

Selective elimination of amplified CDK4 sequences correlates with spontaneous adipocytic differentiation in liposarcoma.
score: 3.0393344, Genes, chromosomes & cancer, 2009, Hélias-Rodzewicz, Zofia et. al.

Treatment in advanced colorectal cancer: what, when and how?
score: 3.0383463, British Journal of Cancer, 2009, Chau, I; Cunningham, D

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
score: 3.0380632, Oncogene, 2000, Krieg, M et. al.

Epidermal growth factor receptor expression status in lung cancer correlates with its mutation
score: 3.0366546, Human Pathology, 2005, Suzuki, Makoto et. al.

Loss of Heterozygosity Occurs Centromeric to RB Without Associated Abnormalities in the Retinoblastoma Gene in Tumors from Patients with Metastatic Renal Cell Carcinoma
score: 3.033324, The Journal of Urology, 1995, Walther, McClellan M. et. al.

Neoplastic progression in ulcerative colitis: Histology, DNA content, and loss of a p53 allele
score: 3.0324359, Gastroenterology, 1992, Burmer, Glenna C. et. al.

ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers
score: 3.0323313, Gene, 2004, Johnstone, Cameron N. et. al.

Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors.
score: 3.0322992, Brain pathology (Zurich, Switzerland), 1995, Louis, D N; Ramesh, V; Gusella, J F

Point mutation of K- ras gene in cisplatin-induced lung tumours in A/J mice
score: 3.0317625, Lung Cancer, 2007, Hisamoto, Akiko et. al.

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.
score: 3.0312724, British journal of cancer, 2011, Lamont, F R et. al.

Prognostic value of mutations and a germ line polymorphism of the p53 gene in non-small cell lung carcinoma: association with clinicopathological features
score: 3.031158, Cancer Letters, 1998, Tagawa, Masatoshi; Murata, Motoi; Kimura, Hideki

Myelodysplastic syndromes
score: 3.0309542, Critical Reviews in Oncology and Hematology, 1996, San Miguel, J.E.sús F. et. al.

Mdm-2: "big brother" of p53.
score: 3.0304741, Journal of cellular biochemistry, 1997, Momand, J; Zambetti, G P

Caveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/α-β catenins complex and multiple ErbB receptors and with lymph nodes metastasis in head and neck squamous cell carcinomas.
score: 3.0304602, Journal of cellular physiology, 2012, Masuelli, Laura et. al.

Genetic and epigenetic changes in lung carcinoma and their clinical implications.
score: 3.0301268, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011, Wen, Jing; Fu, Jianhua; Zhang, Wei; Guo, Ming

Therapy-related acute myeloid leukaemia with mutated NPM1: treatment induced or de novo in origin?
score: 3.0301096, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Falini, B

Investigating human leukemogenesis: from cell lines to in vivo models of human leukemia.
score: 3.0294501, Leukemia, 2008, Kennedy, J A; Barabé, F

Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma.
score: 3.0278249, Oncogene, 1997, Arap, W; Knudsen, E S; Wang, J Y; Cavenee, W K; Huang, H J

Hypermethylation of the CDKN2/p16 INK4A Promotor in Thyroid Carcinogenesis
score: 3.027615, Pathology - Research and Practice, 2003, Boltze, Carsten et. al.

Systemic Mast Cell Disease Without Associated Hematologic Disorder: A Combined Retrospective and Prospective Study
score: 3.0253769, Mayo Clinic Proceedings, 2002, Pardanani, Animesh et. al.

Systemic Mast Cell Disease Without Associated Hematologic Disorder: A Combined Retrospective and Prospective Study
score: 3.0253769, Mayo Clinic Proceedings, 2002, Pardanani, Animesh et. al.

Molecular cytogenetics of childhood hematological malignancies.
score: 3.0247242, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1997, Martinez-Climent, J A

Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes.
score: 3.0246924, International journal of cancer. Journal international du cancer, 2010, Michel, Sara et. al.

No evidence for amplification of V617F JAK2 in myeloproliferative disorders.
score: 3.0243136, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Jones, A V; Bunyan, D J; Cross, N C P

Prognostic significance of p53 abnormalities in colorectal carcinoma detected by PCR-SSCP and immunohistochemical analysis.
score: 3.0239925, The Journal of pathology, 1996, Leahy, D T et. al.

Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions.
score: 3.0236569, Cancer research, 2011, Liu, Wanqing et. al.

Ras oncogenes in oral cancer: The past 20 years
score: 3.0228748, Oral Oncology, 2012, Murugan, Avaniyapuram Kannan et. al.

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.
score: 3.0228502, Oncogene, 2012, Dittmann, L M et. al.

Modern classification of neoplasms: reconciling differences between morphologic and molecular approaches
score: 3.0225809, BMC Cancer, 2005, Berman, Jules

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.
score: 3.0214522, International journal of cancer. Journal international du cancer, 2000, Wang, D S et. al.

Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas.
score: 3.0204498, British journal of cancer, 2009, Nakayama, S et. al.

Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability.
score: 3.0200979, Genes, chromosomes & cancer, 2003, Potocnik, Uros; Glavac, Damjan; Ravnik-Glavac, Metka

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
score: 3.0199558, Nature, 2008, Ley, Timothy J et. al.

Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders.
score: 3.0196446, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Bochtler, T et. al.

Familial predisposition to adrenocortical tumors: Clinical and biological features and management strategies
score: 3.0194792, Best Practice & Research Clinical Endocrinology & Metabolism, 2010, Ribeiro, Raul C.; Pinto, Emilia M.; Zambetti, Gerard P.

p53 and DPC4 alterations in the bile of patients with pancreatic carcinoma.
score: 3.0188713, Journal of surgical oncology, 2004, Pantalone, Desiree et. al.

Myelomastocytic overlap syndromes: biology, criteria, and relationship to mastocytosis
score: 3.0184282, Leukemia Research, 2001, Valent, Peter et. al.

DNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumours.
score: 3.0180405, Neuropathology and applied neurobiology, 2006, Felsberg, J et. al.

p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl- N-(4-hydroxybutyl)-nitrosamine
score: 3.0165272, Cancer Letters, 1996, Masui, Tsuneo et. al.

Cancer gene discovery in hepatocellular carcinoma
score: 3.0164504, Journal of Hepatology, 2010, Zender, Lars et. al.

Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors
score: 3.0149301, Cancer Letters, 2001, Takebayashi, Yuji et. al.

Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas
score: 3.0149023, Cancer Genetics and Cytogenetics, 2008, Italiano, Antoine et. al.

Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma
score: 3.0145076, The Journal of Experimental Medicine, 2012, Kiel, Mark J. et. al.

A novel tumor suppressor function for the Notch pathway in myeloid leukemia
score: 3.0142191, Nature, 2011, Klinakis, Apostolos et. al.

p53 gene aberrations in non-small-cell lung carcinomas from a smoking population.
score: 3.0135761, British journal of cancer, 1997, Liloglou, T et. al.

Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor Treatment
score: 3.0134373, Korean Journal of Pathology, 2013, Lee, Hyun Ju et. al.

Microsatellite instability in pediatric and adult high-grade gliomas.
score: 3.0130943, Brain pathology (Zurich, Switzerland), 2007, Eckert, Anika et. al.

The Role of p53 in Megakaryocyte Differentiation and the Megakaryocytic Leukemias of Down Syndrome
score: 3.0130645, Cancer Genetics and Cytogenetics, 2000, Malkin, David; Brown, Elizabeth J; Zipursky, Alvin

Genomic aberrations in renal cell carcinomas detected by restriction landmark genomic scanning
score: 3.0126226, European Journal of Cancer, 1998, Cho, M et. al.

Understanding urothelial carcinoma through cancer pathways.
score: 3.0125566, International journal of cancer. Journal international du cancer, 2006, Schulz, Wolfgang A

Low frequency of ras activation in 2-acetylaminofluorene- and 3′-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas
score: 3.0120871, Cancer Letters, 1991, Li, H. et. al.

Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor
score: 3.0115475, Lung Cancer, 2010, Jung, Seung-Hyun et. al.

Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease
score: 3.0109013, International Journal of Alzheimer's Disease, 2010, Chadwick, Wayne et. al.

The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models
score: 3.0101169, British Journal of Cancer, 2009, Faur, N et. al.

K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
score: 3.0099131, Cancer research, 1997, Zhu, D et. al.

Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia.
score: 3.0099082, Oncogene, 1997, Panagopoulos, I et. al.

Inactivation of the candidate tumor suppressor par-4 in endometrial cancer.
score: 3.0098266, Cancer research, 2007, Moreno-Bueno, Gema et. al.

Genomic Deletion of PTEN Is Associated with Tumor Progression and Early PSA Recurrence in ERG Fusion-Positive and Fusion-Negative Prostate Cancer
score: 3.0094595, The American Journal of Pathology, 2012, Krohn, Antje et. al.

IGF1 Is a Common Target Gene of Ewing's Sarcoma Fusion Proteins in Mesenchymal Progenitor Cells
score: 3.0091939, PLoS ONE, 2008, Cironi, Luisa et. al.

Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells.
score: 3.0089142, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Besaratinia, Ahmad; Kim, Sang-In; Pfeifer, Gerd P

Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling.
score: 3.0072439, Oncogene, 2011, Knauf, J A et. al.

Recurrent patterns of dual RB and p53 pathway inactivation in melanoma.
score: 3.0065886, The Journal of investigative dermatology, 2005, Yang, Guang; Rajadurai, Anpuchchelvi; Tsao, Hensin

Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.
score: 3.0063777, British Journal of Cancer, 1995, McCann, A. H. et. al.

A distinctive translocation carcinoma of the kidney; “rosette forming,” t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases
score: 3.0061863, Human Pathology, 2012, Petersson, Fredrik et. al.

Mutational spectrum of p53 mutations in primary breast and ovarian tumors
score: 3.00469, Critical Reviews in Oncology and Hematology, 2004, Feki, Anis; Irminger-Finger, Irmgard

Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region.
score: 3.0038795, British Journal of Cancer, 1995, Leggett, B. et. al.

Primary pulmonary and mediastinal synovial sarcoma: a clinicopathologic study of 60 cases and comparison with five prior series.
score: 3.0030169, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2007, Hartel, Paul H et. al.

C/EBPα: A tumour suppressor in multiple tissues?
score: 3.0029368, BBA - Reviews on Cancer, 2006, Schuster, Mikkel Bruhn; Porse, Bo Torben

Clinical implications of C-kit gene mutation in patients with large gastrointestinal stromal tumors.
score: 3.0023394, Journal of gastroenterology and hepatology, 2006, Lin, Shee-Chan et. al.

Nilotinib: optimal therapy for patients with chronic myeloid leukemia and resistance or intolerance to imatinib
score: 3.0021199, Drug design, development and therapy, 2009, Swords, Ronan et. al.

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis.
score: 3.0017071, British Journal of Cancer, 1997, Vos, C. B. et. al.

DNA repair gene O6-methylguanine-DNA methyltransferase: promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors.
score: 3.0006949, Molecular carcinogenesis, 2003, Yin, Dong et. al.

Exploring molecular genetics of bladder cancer: lessons learned from mouse models.
score: 3.0006352, Disease models & mechanisms, 2012, Ahmad, Imran; Sansom, Owen J; Leung, Hing Y

Distinct pattern of mutations of conserved regions of TP53 in colorectal cancer patients in the Kashmir population: an emerging high-risk area
score: 3.0005589, ecancermedicalscience, 2009, Rehman, S et. al.

Genetic alterations on 3p, 11q13, and 18q in nonfamilial and MEN 1-associated pancreatic endocrine tumors.
score: 2.9987661, Genes, chromosomes & cancer, 1999, Hessman, O et. al.

Acute myeloid leukemia with 17p abnormality in untreated essential thrombocythemia.
score: 2.9982733, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2001, Hernández, J A; Florensa, L; Solé, F; Bosch, M A; Espinet, B

Identification of a novel duplication in the APC gene using multiple ligation probe amplification in a patient with familial adenomatous polyposis
score: 2.9963007, Cancer Genetics and Cytogenetics, 2008, Pedace, Lucia et. al.

Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families
score: 2.9962045, Cancer Genetics and Cytogenetics, 2002, Balz, Vera; Prisack, Hans Bernd; Bier, Henning; Bojar, Hans

Systemic mastocytosis in association with plasma cell dyscrasias: Report of a case and review of the literature
score: 2.9961031, Leukemia Research, 2009, Motwani, Pooja; Kocoglu, Mehmet; Lorsbach, Robert B.

Targeting ErbB3-mediated stromal-epithelial interactions in pancreatic ductal adenocarcinoma.
score: 2.9953428, British journal of cancer, 2011, Liles, J S et. al.

p16/INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis.
score: 2.994978, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2005, Takino, Hisashi et. al.

Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations.
score: 2.9946537, The British journal of surgery, 1998, Midwinter, M J

Resistance to imatinib (Glivec): update on clinical mechanisms
score: 2.994589, Drug Resistance Updates, 2003, Weisberg, Ellen; Griffin, James D.

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.
score: 2.9945497, Cancer research, 2004, Sieber, Oliver M et. al.

Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics
score: 2.9945111, European Journal of Cancer, 2008, Deng, Guoren et. al.

Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma.
score: 2.9940444, Cancer research, 1996, Marsh, D J et. al.

EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A.
score: 2.9938444, Oncogene, 2010, Gascoyne, D M et. al.

Chronic Myeloid Leukemia: Diagnosis and Treatment
score: 2.9905716, Mayo Clinic Proceedings, 2006, Quintás-Cardama, Alfonso; Cortes, Jorge E.

Chronic Myeloid Leukemia: Diagnosis and Treatment
score: 2.9905716, Mayo Clinic Proceedings, 2006, Quintás-Cardama, Alfonso; Cortes, Jorge E.

The BRAF V600E mutation: what is it really orchestrating in thyroid cancer?
score: 2.9900199, Oncotarget, 2010, Nucera, Carmelo et. al.

High frequency of p53 mutations in human oral epithelial dysplasia and primary squamous cell carcinoma detected by yeast functional assay.
score: 2.9899764, Oncogene, 1997, Kashiwazaki, H et. al.

Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to replication error phenotype.
score: 2.9895895, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 1999, Horiike, S et. al.

Inherited Carcinomas of the Kidney
score: 2.988858, Advances in Cancer Research, 1998, Zbar, Berton; Lerman, Michael

Inherited Carcinomas of the Kidney
score: 2.988858, Advances in Cancer Research, 1998, Zbar, Berton; Lerman, Michael

Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed müllerian tumours.
score: 2.9888557, The Journal of pathology, 1997, Abeln, E C et. al.

The gene expression profile of extraskeletal myxoid chondrosarcoma.
score: 2.9887646, The Journal of pathology, 2005, Subramanian, Subbaya et. al.

Minimal residual disease based on patient specific Flt3-ITD and -ITT mutations in acute myeloid leukemia
score: 2.988669, Leukemia Research, 2005, Scholl, Sebastian et. al.

High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas.
score: 2.9867019, Oncogene, 2002, Miyaki, Michiko et. al.

Prognostic value of FLT3 mutations among different cytogenetic subgroups in acute myeloid leukemia.
score: 2.9863824, Cancer, 2011, Santos, Fabio P S et. al.

Resistance to imatinib, low-grade FDG-avidity on PET, and acquired KIT exon 17 mutation in gastrointestinal stromal tumour
score: 2.985968, Lancet Oncology, 2005, Grimpen, Florian et. al.

Mutation analysis of glial cell line-derived neurotrophic factor (GDNF), a ligand for the RET/GDNF receptor alpha complex, in sporadic phaeochromocytomas.
score: 2.9847504, Cancer research, 1997, Dahia, P L et. al.

Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients.
score: 2.9843257, Cancer research, 2002, Ladanyi, Marc et. al.

Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors
score: 2.9840926, Leukemia Research, 2010, Muranyi, Andrew L.; Dedhar, Shoukat; Hogge, Donna E.

EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma.
score: 2.983253, Cancer research, 2008, Ban, Jozef et. al.

Mutational analysis of the transforming growth factor β receptor type I gene in primary non-small cell lung cancer
score: 2.9831615, Lung Cancer, 2003, Zhang, Hong-Tao et. al.

BRCA2 Is Inactivated Late in the Development of Pancreatic Intraepithelial Neoplasia
score: 2.9831434, The American Journal of Pathology, 2000, Goggins, Michael; Hruban, Ralph H.; Kern, Scott E.

Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas.
score: 2.9827987, British Journal of Cancer, 1996, Smith, D. R.; Ji, C. Y.; Goh, H. S.

Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy.
score: 2.9816163, American journal of hematology, 2008, Tefferi, Ayalew

Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression.
score: 2.9812962, Proceedings of the National Academy of Sciences of the United States of America, 2004, Masayesva, Brett G et. al.

Differential prognosis of replication error phenotype and loss of heterozygosity in sporadic colorectal cancer
score: 2.9810287, European Journal of Cancer, 1999, Massa, M.-J. et. al.

Molecular fine-needle aspiration biopsy diagnosis of thyroid nodules by tumor specific mutations and gene expression patterns
score: 2.9808354, Molecular and Cellular Endocrinology, 2010, Eszlinger, Markus; Paschke, Ralf

Phosphorylated AKT and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecan-cetuximab
score: 2.9797148, Journal of Translational Medicine, 2012, Scartozzi, Mario et. al.

Is JAK2 V617F mutation more than a diagnostic index?
score: 2.9791814, Leukemia Research, 2009, Dahabreh, Issa J. et. al.

Primary vs. secondary neoplasia-associated chromosomal abnormalities--balanced rearrangements vs. genomic imbalances?
score: 2.9790124, Genes, chromosomes & cancer, 1996, Johansson, B; Mertens, F; Mitelman, F

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer.
score: 2.9789548, Cancer research, 2013, Fleming, Nicholas I et. al.

Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
score: 2.9782293, Cancer research, 1998, Bernhard, E J et. al.

Function, regulation and pathological roles of the Gab/DOS docking proteins
score: 2.97797, Cell Communication and Signaling : CCS, 2009, Wöhrle, Franziska U; Daly, Roger J; Brummer, Tilman

Independent prognostic role of p16 expression in lung cancer
score: 2.976886, The Journal of Thoracic and Cardiovascular Surgery, 1999, Groeger , Angela M. et. al.

Frequent and heterogeneous expression of cyclin-dependent kinase inhibitor WAF1/p21 protein and mRNA in urothelial carcinoma.
score: 2.9762322, British Journal of Cancer, 1998, Clasen, S. et. al.

Molecular analysis of genomic abnormalities in human gliomas
score: 2.9755592, Cancer Genetics and Cytogenetics, 1994, Bello, M.Josefa et. al.

Fusion of dynactin 1 to anaplastic lymphoma kinase in inflammatory myofibroblastic tumor
score: 2.9753136, Human Pathology, 2012, Wang, Xiaoke et. al.

Analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma
score: 2.9742613, Virchows Archiv, 2011, Lee, Sung et. al.

Mixed Medullary-Follicular Thyroid Carcinoma
score: 2.9741815, The American Journal of Pathology, 1999, Volante, Marco et. al.

Long term follow up of 93 families with myeloproliferative neoplasms: life expectancy and implications of JAK2V617F in the occurrence of complications
score: 2.9720195, Blood Cells, Molecules and Diseases, 2012, Malak, Sandra et. al.

ALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular aspects of lymph nodes mimicking inflammatory lesions.
score: 2.9717332, European journal of haematology, 2003, Borisch, B et. al.

Beyond RET: potential therapeutic approaches for advanced and metastatic medullary thyroid carcinoma.
score: 2.9713292, Journal of internal medicine, 2009, Santarpia, L; Ye, L; Gagel, R F

Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers
score: 2.9709605, Molecular Systems Biology, 2013, Reimand, Jüri; Bader, Gary D

Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
score: 2.9684913, Human molecular genetics, 2004, Kakiuchi, Soji et. al.

High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma.
score: 2.9681659, Genes, chromosomes & cancer, 2011, Giefing, Maciej et. al.

Determination of vhl Gene Mutations in Sporadic Renal Cell Carcinoma
score: 2.9681314, European Urology, 2006, Giménez-Bachs, José Miguel et. al.

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas
score: 2.9671487, The American Journal of Pathology, 2009, Watanabe, Takuya et. al.

Clustered DNA lesion sites as a source of mutations during human colorectal tumourigenesis
score: 2.9666779, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2008, Radford, Ian R.; Lobachevsky, Pavel N.

The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis
score: 2.9665038, DNA Repair, 2004, Hildesheim, Jeffrey; Fornace, Albert J

Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia.
score: 2.9653891, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2006, Score, J et. al.

Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia.
score: 2.9649813, International journal of cancer. Journal international du cancer, 2011, Ikezoe, Takayuki et. al.

Low-level microsatellite instability in most colorectal carcinomas.
score: 2.9646572, Cancer research, 2002, Laiho, Päivi et. al.

Molecular advances in the etiology and treatment of colorectal cancer
score: 2.9644433, Surgical Oncology, 1997, Bradley, Brian A; Evers, B.Mark

New recurrent deletions in the PPARγ and TP53 genes are associated with childhood myelodysplastic syndrome
score: 2.9636938, Leukemia Research, 2009, Silveira, Cássia G.T. et. al.

The clinical impact of DNA methylation frequencies of JAK2 negative regulators in patients with essential Thrombocythemia
score: 2.9628083, Leukemia Research, 2012, Födermayr, Mathilde et. al.

Management of stage II colon cancer - the use of molecular biomarkers for adjuvant therapy decision
score: 2.9627808, BMC Gastroenterology, 2013, Donada, Marisa et. al.

DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours.
score: 2.9622238, Histopathology, 2010, Novelli, Marco et. al.

Mutation of the PIK3CA oncogene in human cancers
score: 2.9616656, British Journal of Cancer, 2006, Karakas, B; Bachman, K E; Park, B H

Familial vs sporadic ovarian tumors: characteristic genomic alterations analyzed by CGH
score: 2.9610193, Gynecologic Oncology, 2003, Israeli, Ofir et. al.

Acute myeloid leukaemia with associated eosinophilia: justification for FIP1L1-PDGFRA screening in cases lacking the CBFB-MYH11 fusion gene.
score: 2.9607855, British journal of haematology, 2009, Sorour, Youssef et. al.

Thrombophilia Screening: Little Role for the JAK2V617F Mutation
score: 2.9600603, Mayo Clinic Proceedings, 2008, Mannucci, Pier Mannuccio; Peyvandi, Flora

Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis.
score: 2.9557072, Oncogene, 2011, Rohlin, A et. al.

5′ Region and Exon 7 Mutations of the TP53 Gene in Two Cases of B-Cell Prolymphocytic Leukemia
score: 2.955506, Cancer Genetics and Cytogenetics, 1998, De Angeli, Cristiano et. al.

Vía de señalización dependiente de la proteincinasa de activación mitogénica en el carcinoma papilar de tiroides. De las bases moleculares a la práctica clínica
score: 2.954426, Endocrinologia y Nutricion, 2009, Zafon, Carles; Obiols, Gabriel

HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients
score: 2.9544096, British Journal of Cancer, 2005, Cappuzzo, F et. al.

Pediatric-type sarcomas in adult patients
score: 2.9537146, Seminars in Diagnostic Pathology, 2003, Montesco, M.C; Alaggio, R; Ninfo, Vito

Differential roles of SS18–SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth
score: 2.9535648, Biochemical and Biophysical Research Communications, 2008, Törnkvist, Maria et. al.

MicroRNAs: new players in acute myeloid leukaemia
score: 2.9532999, British Journal of Cancer, 2009, Havelange, V; Garzon, R; Croce, C M

Mutations in TP53 tumor suppressor gene in wood dust-related sinonasal cancer.
score: 2.9522164, International journal of cancer. Journal international du cancer, 2010, Holmila, Reetta et. al.

Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype.
score: 2.9521727, British journal of cancer, 2008, Kawakami, K et. al.

Pathological features and genetic alterations in colorectal carcinomas with characteristics of nonpolypoid growth.
score: 2.9514624, British journal of cancer, 2004, Kaneko, K et. al.

t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia.
score: 2.9513262, Genes, chromosomes & cancer, 2003, Vizmanos, José L et. al.

Genetic Pathways Leading to Therapy-Related Myeloid Neoplasms
score: 2.9512376, Mediterranean Journal of Hematology and Infectious Diseases, 2011, Stoddart, Angela et. al.

Establishment of an in vivo model for pediatric Ewing tumors by transplantation into NOD/scid mice.
score: 2.9510847, Pediatric research, 2001, Vormoor, J et. al.

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
score: 2.9507724, Cancer research, 2000, Esteller, M et. al.

Comprehensive Analysis of SMAD4 Mutations and Protein Expression in Juvenile Polyposis
score: 2.9502675, The American Journal of Pathology, 2001, Woodford-Richens, Kelly L. et. al.

Cancer heterogeneity: implications for targeted therapeutics
score: 2.9498489, British Journal of Cancer, 2013, Fisher, R; Pusztai, L; Swanton, C

Adenovirus E1A does not induce the Ewing tumor-associated gene fusion EWS-FLI1.
score: 2.9498389, Cancer research, 2000, Kovar, H et. al.

HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers
score: 2.9496207, The American Journal of Pathology, 2010, Baba, Yoshifumi et. al.

ATRA can enhance apoptosis that is induced by Flt3 tyrosine kinase inhibition in Flt3-ITD positive cells
score: 2.9494988, Leukemia Research, 2006, Scholl, S. et. al.

STAT signaling in the pathogenesis and treatment of leukemias.
score: 2.9483938, Oncogene, 2000, Lin, T S; Mahajan, S; Frank, D A

Hypomethylation of the IGF2 DMR in Colorectal Tumors, Detected by Bisulfite Pyrosequencing, Is Associated With Poor Prognosis
score: 2.9479635, Gastroenterology, 2010, Baba, Yoshifumi et. al.

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma.
score: 2.9469053, British journal of cancer, 1999, Mihara, M et. al.

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.
score: 2.9454632, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, McCormack, E et. al.

Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast.
score: 2.9454151, Histopathology, 2008, Lee, A H S

Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation.
score: 2.9453431, International journal of cancer. Journal international du cancer, 2006, Bertelsen, Bjørn I et. al.

Converging pathways in leukemogenesis and stem cell self-renewal
score: 2.9426511, Experimental Hematology, 2005, Moore, Malcolm A.S.

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
score: 2.9425575, Proceedings of the National Academy of Sciences of the United States of America, 2002, Sieber, O M et. al.

Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes
score: 2.9420065, Experimental Hematology, 2008, Wulfert, Michael et. al.

Prostate tumours from an Asian population: examination of bax, bcl-2, p53 and ras and identification of bax as prognostic marker
score: 2.9417101, British Journal of Cancer, 2000, Chia, S-J et. al.

Molecular mechanisms of hepatocellular carcinoma.
score: 2.941684, Hepatology (Baltimore, Md.), 2008, Aravalli, Rajagopal N; Steer, Clifford J; Cressman, Erik N K

Cellular and molecular biology of biliary tract cancers
score: 2.9410986, Surgical Oncology Clinics of North America, 2002, Rashid, Asif

Tyrosine kinase fusion genes in chronic myeloproliferative diseases.
score: 2.9408724, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002, Cross, N C P; Reiter, A

Chromosomal alterations in ulcerative colitis-related and sporadic colorectal cancers by comparative genomic hybridization
score: 2.9393285, Human Pathology, 2000, Aust, Daniela E. et. al.

Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia.
score: 2.9385174, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Metzler, M et. al.

Exploring molecular genetics of bladder cancer: lessons learned from mouse models
score: 2.9381588, Disease Models & Mechanisms, 2012, Ahmad, Imran; Sansom, Owen J.; Leung, Hing Y.

New insights into p53 protein stabilisation in oral squamous cell carcinoma
score: 2.9380214, Oral Oncology, 1999, Partridge, M et. al.

P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development.
score: 2.9379555, International journal of cancer. Journal international du cancer, 2009, van Veelen, Wendy et. al.

Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours
score: 2.9377967, British Journal of Cancer, 2005, Marian, C et. al.

DNA Methylation Analysis Using Bisulfite Treatment and PCR–Single-Strand Conformation Polymorphism in Colorectal Cancer Showing Microsatellite Instability
score: 2.9365362, Biochemical and Biophysical Research Communications, 1999, Maekawa, Masato et. al.

Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability.
score: 2.9361008, Oncogene, 2006, Koinuma, K et. al.

Upregulation of p16(INK4A) and Bax in p53 wild/p53-overexpressing crypts in ulcerative colitis-associated tumours.
score: 2.9359677, British journal of cancer, 2004, Yoshida, T; Matsumoto, N; Mikami, T; Okayasu, I

Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma.
score: 2.9353221, The Journal of pathology, 2004, Pallares, Judit et. al.

Detection of somatic TP53 splice site mutations in diffuse astrocytomas
score: 2.9349944, Cancer Letters, 2005, Uno, Miyuki et. al.

Identification of seven new BRCA1 germline mutations in Italian breast and breast/ovarian cancer families.
score: 2.9344033, Cancer research, 1996, Montagna, M et. al.

FREQUENTLY DELETED LOCI ON CHROMOSOME 9 MAY HARBOR SEVERAL TUMOR SUPPRESSOR GENES IN HUMAN RENAL CELL CARCINOMA
score: 2.9338228, The Journal of Urology, 2001, GRADY, BRIAN et. al.

p53 and p21/Waf1 protein expression and K- ras codon 12 mutation in carcinoma of the papilla of Vater
score: 2.9334359, The American Journal of Gastroenterology, 1999, Zhao, Bin et. al.

Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene.
score: 2.9321516, British journal of haematology, 1999, Nakano, Y et. al.

Emergence of Chronic Myelogenous Leukemia From a Background of Myeloproliferative Disorder:JAK2V617Fas a Potential Risk Factor forBCR-ABLTranslocation
score: 2.9319089, Clinical Lymphoma & Myeloma, 2009, Pingali, Sai Ravi Kiran et. al.

Alterations of cell cycle regulators affecting the RB pathway in nonfamilial retinoblastoma
score: 2.9313191, Human Pathology, 2001, Orjuela, Manuela et. al.

High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.
score: 2.9312853, Cancer research, 2009, Holstege, Henne et. al.

Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia.
score: 2.9308751, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2005, Noguera, N I et. al.

Lack of p53 point mutations in chemically induced mouse hepatoblastomas: an end-stage, highly malignant hepatocellular tumor
score: 2.9307372, Cancer Letters, 1995, Calvert, Richard J. et. al.

Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia.
score: 2.930369, British journal of cancer, 1999, Zhu, Y M et. al.

Identification of recurrent chromosomal aberrations in germ cell tumors of neonates and infants using genomewide array-based comparative genomic hybridization.
score: 2.9303069, Genes, chromosomes & cancer, 2005, Veltman, Imke et. al.

Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma.
score: 2.9298612, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012, Kakar, Sanjay et. al.

Alterations in exon 4 of the p53 gene in gastric carcinoma
score: 2.9290272, Gastroenterology, 2000, Shepherd, Tara et. al.

Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis
score: 2.9269794, Nature Genetics, 2011, March, H. Nikki et. al.

The inherited genetics of pancreatic cancer and prospects for secondary screening
score: 2.9259778, Best Practice & Research Clinical Gastroenterology, 2006, Vitone, Louis J. et. al.

Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development.
score: 2.9251577, Genes, chromosomes & cancer, 2009, Missiaglia, Edoardo et. al.

Trisomy 8 as the sole chromosomal aberration in myelocytic malignancies
score: 2.9247612, Cancer Genetics and Cytogenetics, 2003, Paulsson, Kajsa et. al.

The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
score: 2.9240015, The Journal of pathology, 2011, Shalaby, Asem et. al.

Neurofibromatosis 2011: a report of the Children’s Tumor Foundation Annual Meeting
score: 2.9239695, Acta Neuropathologica, 2011, Kalamarides, Michel et. al.

Over-expression of Flt3 induces NF-κB pathway and increases the expression of IL-6
score: 2.9239239, Leukemia Research, 2005, Takahashi, Shinichiro et. al.

Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection
score: 2.9224389, Gene, 1999, Odeberg, Jacob et. al.

Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia.
score: 2.9222304, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Niemann, C U et. al.

Genetic pathways in colorectal and other cancers 1 Reprinted from Eur J Cancer 1999, 35(3), 335–351. Please use this reference when citing this article. 1
score: 2.9219814, European Journal of Cancer, 1999, Ilyas, M; Straub, J; Tomlinson, I.P.M; Bodmer, W.F

Timing and role of p53 gene mutation in the recurrence of glioma
score: 2.9216694, Biochemical and Biophysical Research Communications, 1991, Hayashi, Yutaka; Yamashita, Junkoh; Yamaguchi, Kazuo

P53, MAPK, topoisomerase II alpha and Ki67 immunohistochemical expression and KRAS/BRAF mutation in ovarian serous carcinomas
score: 2.9210979, Diagnostic Pathology, 2013, Sundov, Dinka et. al.

Allelotype of salivary gland tumors.
score: 2.9202279, Cancer research, 1996, Johns, M M et. al.

Detection of fusion genes in sarcomas using paraffin-embedded tissues.
score: 2.9197571, Neuropathology : official journal of the Japanese Society of Neuropathology, 2005, Yoshida, Keiichi et. al.

The role of cytology specimens in molecular testing of solid tumors: techniques, limitations, and opportunities.
score: 2.9192966, Diagnostic cytopathology, 2012, Aisner, Dara L; Sams, Sharon B

Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing.
score: 2.9186072, Cancer research, 2003, Xing, Mingzhao et. al.

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
score: 2.918492, Cell, 1993, Kemp, Christopher J. et. al.

Beta2-microglobulin mutations in microsatellite unstable colorectal tumors.
score: 2.9184615, International journal of cancer. Journal international du cancer, 2007, Kloor, Matthias et. al.

Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma
score: 2.9182738, Hepatology, 1994, Hsu, Hey-Chi et. al.

Double strand break repair components are frequent targets of microsatellite instability in endometrial cancer
score: 2.9178896, European Journal of Cancer, 2010, Bilbao, Cristina et. al.

Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas.
score: 2.9178058, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2008, Hong, Seung-Mo et. al.

Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.
score: 2.9171007, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009, Kure, Shoko et. al.

EGFR Polymorphism of the Kinase Domain in Japanese Lung Cancer
score: 2.9169836, Journal of Surgical Research, 2008, Sasaki, Hidefumi et. al.

Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation
score: 2.9169073, Annals of Hematology, 2008, Raepple, D. et. al.

A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia
score: 2.9165262, Cancer Genetics and Cytogenetics, 2007, Hidaka, Eiko et. al.

Treatment of gastrointestinal stromal tumor: focus on imatinib mesylate
score: 2.916032, Therapeutics and Clinical Risk Management, 2008, Din, Omar S; Woll, Penella J

Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein DeltaBRCA1(17aa).
score: 2.9147619, Oncogene, 2000, Liu, J et. al.

Smac mimetics: implications for enhancement of targeted therapies in leukemia.
score: 2.9147377, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Weisberg, E et. al.

Frequency of defective DNA mismatch repair in colorectal cancer among the Alaska Native people.
score: 2.9141407, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Boardman, Lisa A et. al.

Frequent loss of heterozygosity for Rb, TP53, and chromosome arm 3p, but not NME1 in squamous cell carcinomas of the supraglottic larynx.
score: 2.9140599, Cancer, 1994, Scholnick, S B et. al.

p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans.
score: 2.9125965, EMBO molecular medicine, 2012, Wild, Peter J et. al.

Cysteine-Rich Secretory Protein-3 ( CRISP3 ) Is Strongly Up-Regulated in Prostate Carcinomas with the TMPRSS2-ERG Fusion Gene
score: 2.9125263, PLoS ONE, 2011, Ribeiro, Franclim R. et. al.

Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer.
score: 2.911986, Oncogene, 1999, Lee, S H et. al.

N- ras mutation in 7,12-dimethylbenz[a]anthracene (DMBA)-induced erythroleukemia in long-evans rats
score: 2.9113659, Cancer Letters, 1995, Osaka, Mitsuhiko et. al.

Changes in allelic imbalances in locally advanced breast cancers after chemotherapy
score: 2.9111616, British Journal of Cancer, 2007, Varna, M et. al.

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers.
score: 2.9110879, Cancer research, 2007, Arena, Sabrina et. al.

Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature
score: 2.9110567, Leukemia Research, 2004, Hauswirth, Alexander W et. al.

Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations.
score: 2.9096308, Cancer research, 2010, Yamamoto, Chizuko et. al.

Multistage carcinogenesis in Barrett's esophagus
score: 2.9092266, Cancer Letters, 2007, Maley, Carlo C.

Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature.
score: 2.9088711, Pediatric blood & cancer, 2009, Benesch, Martin et. al.

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.
score: 2.9082038, Proceedings of the National Academy of Sciences of the United States of America, 1996, FitzGerald, M G et. al.

Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells
score: 2.9081127, Leukemia Research, 2008, Dobbin, E. et. al.

Quantitative profiling of codon 816 KIT mutations can aid in the classification of systemic mast cell disease.
score: 2.9079014, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Zhao, W et. al.

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.
score: 2.9074042, International journal of cancer. Journal international du cancer, 2006, Grady, William M et. al.

Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells
score: 2.9070146, Cellular Signalling, 2004, Halaschek-Wiener, Julius et. al.

Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas.
score: 2.9066224, Cancer research, 1993, Wagata, T et. al.

Oncogenes in human testicular cancer: DNA and RNA studies.
score: 2.9064541, British Journal of Cancer, 1991, Peltomäki, P.; Alfthan, O.; de la Chapelle, A.

The quantitative JAK2 V617F neutrophil allele burden does not correlate with thrombotic risk in essential thrombocytosis.
score: 2.9062337, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Pemmaraju, N et. al.

Upregulation of p16 INK4A and Bax in p53 wild/p53-overexpressing crypts in ulcerative colitis-associated tumours
score: 2.9061634, British Journal of Cancer, 2004, Yoshida, T; Matsumoto, N; Mikami, T; Okayasu, I

ALK and NSCLC: Targeted therapy with ALK inhibitors
score: 2.905521, F1000 Medicine Reports, 2011, Hallberg, Bengt; Palmer, Ruth H.

KRAS variation and risk of endometriosis.
score: 2.9054445, Molecular human reproduction, 2006, Zhao, Zhen Zhen et. al.

Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers
score: 2.9051308, European Journal of Cancer, 2009, Soria, J.C. et. al.

Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
score: 2.9046446, Journal of Molecular Medicine (Berlin, Germany), 2008, Prodosmo, Andrea et. al.

Myelodysplasia with fibrosis: a distinct entity?
score: 2.9043018, Leukemia Research, 2001, Steensma, David P. et. al.

RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis
score: 2.9042604, Cancer Genetics and Cytogenetics, 2006, Iglesias, Daniel et. al.

Somatic gene mutation and human disease other than cancer: An update
score: 2.9040907, Mutation Research-Reviews in Mutation Research, 2010, Erickson, Robert P.

Detection of TP53 gene mutations in human sarcomas
score: 2.9021518, European Journal of Cancer, 1995, Castresana, J.S. et. al.

Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation.
score: 2.9013787, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Tyner, J W et. al.

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
score: 2.9010443, British Journal of Cancer, 1993, Burns, J. E. et. al.

Possible new LNK mutations in myeloproliferative neoplasms.
score: 2.9006875, American journal of hematology, 2011, Ha, Jung-Sook; Jeon, Dong-Seok

Genetic alterations in melanocytic tumors
score: 2.8999954, Journal of Dermatological Science, 2006, Takata, Minoru; Saida, Toshiaki

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
score: 2.8999387, Cell Communication and Signaling : CCS, 2012, Arora, Deepika et. al.

Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours.
score: 2.8998052, British journal of cancer, 2009, Jacob, K et. al.

Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines.
score: 2.8995359, Molecular carcinogenesis, 1996, Huang, L et. al.

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
score: 2.8986856, Nature medicine, 2010, Min, Junxia et. al.

How to manage children and young adults with myeloproliferative neoplasms.
score: 2.8978643, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Barbui, T

The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer
score: 2.8977684, European Journal of Cancer, 1997, Esteller, M. et. al.

Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.
score: 2.8968776, Cancer research, 1997, Gonzalgo, M L et. al.

Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells
score: 2.8968345, Current Biology, 2006, Lim, Kian-Huat et. al.

Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells
score: 2.8968345, Current Biology, 2006, Lim, Kian-Huat et. al.

Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors.
score: 2.8949098, Molecular cancer therapeutics, 2003, Frolov, Andrey et. al.

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma
score: 2.8932641, British Journal of Cancer, 1999, Mihara, M et. al.

In squamous cell carcinoma of the vulva, overexpression of p53 is a late event and neither p53 nor mdm2 expression is a useful marker to predict lymph node metastases.
score: 2.8926557, British journal of cancer, 1999, Emanuels, A G; Koudstaal, J; Burger, M P; Hollema, H

Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma.
score: 2.8916013, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2002, Naumann, Sabine et. al.

Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood
score: 2.8911807, Human Genetics, 2009, Novara, Francesca et. al.

Gene expression profiling in acute myeloid leukaemia (AML)
score: 2.8910631, Best Practice & Research Clinical Haematology, 2009, Bacher, Ulrike et. al.

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
score: 2.8904127, Nature genetics, 2010, Veeriah, Selvaraju et. al.

p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations
score: 2.8900282, Cancer Letters, 2005, Hardie, Laura J. et. al.

FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins.
score: 2.8892196, Oncogene, 2004, Scheijen, Blanca; Ngo, Hai T; Kang, Hyun; Griffin, James D

E-cadherin complex and its abnormalities in human breast cancer
score: 2.888843, Surgical Oncology, 2000, Jiang, Wen G; Mansel, Robert E

Progression of prostatic intraepithelial neoplasia to invasive carcinoma in C3(1)/SV40 large T antigen transgenic mice: histopathological and molecular biological alterations.
score: 2.888687, Cancer research, 1996, Shibata, M A; Ward, J M; Devor, D E; Liu, M L; Green, J E

Absence of p53 gene mutation and infrequent overexpression of p53 protein in hepatoblastoma.
score: 2.8881562, The Journal of pathology, 1995, Chen, T C; Hsieh, L L; Kuo, T T

The reciprocal translocation t(9;16)(q22;p13) is a primary chromosome abnormality in basal cell carcinomas.
score: 2.8879908, Cancer research, 1997, Jin, Y et. al.

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
score: 2.8875372, Cell, 2010, Heidorn, Sonja J. et. al.

Clinical importance of SF3B1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts
score: 2.8863778, Leukemia Research, 2012, Cui, Rui et. al.

The Current Role of Angiogenesis Inhibitors in the Treatment of Renal Cell Carcinoma
score: 2.8861993, Seminars in Oncology, 2006, Choueiri, Toni K.; Bukowski, Ronald M.; Rini, Brian I.

Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells.
score: 2.8861405, Oncogene, 2010, Guo, G et. al.

Functional RET G691S polymorphism in cutaneous malignant melanoma.
score: 2.8859859, Oncogene, 2009, Narita, N et. al.

ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25–26;q22)
score: 2.8854317, Leukemia Research, 2006, Moore, Steven D.P. et. al.

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma
score: 2.8839909, British Journal of Cancer, 2004, Soufir, N et. al.

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours.
score: 2.8828975, Nature, 2009, Rebouissou, Sandra et. al.

Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21).
score: 2.8819367, Genes, chromosomes & cancer, 2003, Bodmer, Daniëlle et. al.

FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm
score: 2.8818926, Cell Stem Cell, 2012, Chu, S. Haihua et. al.

Molecular Classification of Renal Tumors by Gene Expression Profiling
score: 2.8815491, The Journal of Molecular Diagnostics, 2005, Schuetz, Audrey N. et. al.

The presence of clonal cell subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with refractory anemia may reflect a multistep pathogenesis of myelodysplasia
score: 2.8813733, Leukemia Research, 2005, Čermák, Jaroslav et. al.

Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
score: 2.8813561, Cancer research, 2001, Wiesener, M S et. al.

Genotype phenotype correlations in Israeli colorectal cancer patients.
score: 2.8807519, International journal of cancer. Journal international du cancer, 2005, Starinsky, Sigal et. al.

A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss
score: 2.8806298, Cell, 2009, Phelps, Reid A. et. al.

Protein tyrosine kinases and cancer
score: 2.880585, BBA - Reviews on Cancer, 1997, Kolibaba, Kathryn S; Druker, Brian J

Genetic aberrations in paediatric acute leukaemias and implications for management of patients
score: 2.8798255, Lancet Oncology, 2010, Szczepański, Tomasz et. al.

Interlaboratory Development and Validation of a HRM Method Applied to the Detection of JAK2 Exon 12 Mutations in Polycythemia Vera Patients
score: 2.8789561, PLoS ONE, 2010, Ugo, Valerie et. al.

Insights from a whole cystectomy specimen—association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ
score: 2.8786449, Human Pathology, 2008, Gaisa, Nadine Therese et. al.

Establishment and characterisation of a human clear cell sarcoma model in nude mice.
score: 2.878156, International journal of cancer. Journal international du cancer, 2002, Crnalic, Sead et. al.

C-kit protein expression in Wilms' tumour: An immunohistochemical study
score: 2.8778186, European Journal of Surgical Oncology, 2009, Giordano, G. et. al.

Molecular Mechanisms of Uterine Leiomyosarcomas: Involvement of Defect in LMP2 Expression
score: 2.8775976, Gene Regulation and Systems Biology, 2008, Hayashi, Takuma et. al.

Mapping of the 7q31 subregion common to the small chromosome 7 derivatives from two sporadic papillary renal cell carcinomas: increased copy number and overexpression of the MET proto-oncogene.
score: 2.8772316, Oncogene, 2000, Glukhova, L et. al.

Understanding the Importance of Smart Drugs in Renal Cell Carcinoma
score: 2.8766502, European Urology, 2006, Patard, Jean-Jacques et. al.

Loss of heterozygosity on chromosome arm 11q in lung carcinoids
score: 2.8765873, Human Pathology, 2001, Petzmann, Susanna et. al.

V600E Braf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16 INK4a
score: 2.8763221, EMBO Molecular Medicine, 2010, Carragher, Linda A S et. al.

Current Concepts on Dedifferentiation/High-Grade Transformation in Salivary Gland Tumors
score: 2.8762764, Pathology Research International, 2011, Costa, Ana Flávia; Altemani, Albina; Hermsen, Mario

Practical molecular diagnostics in neuropathology: making a tough job a little easier
score: 2.8757401, Seminars in Diagnostic Pathology, 2010, Horbinski, Craig

Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours.
score: 2.874434, British journal of cancer, 2007, Carén, H; Fransson, S; Ejeskär, K; Kogner, P; Martinsson, T

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc Min/+ mouse small intestine
score: 2.8729678, BMC Gastroenterology, 2008, Patek, Charles E et. al.

CGH arrays compared for DNA isolated from formalin-fixed, paraffin-embedded material.
score: 2.8724896, Genes, chromosomes & cancer, 2012, Krijgsman, Oscar et. al.

TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder.
score: 2.8715093, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2009, Armstrong, Andrew B et. al.

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma
score: 2.8709485, British Journal of Cancer, 2000, Tsuda, H; Yamamoto, K; Inoue, T; Uchiyama, I; Umesaki, N

CpG Island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
score: 2.8707414, Gastroenterology, 2002, Hawkins, Nicholas et. al.

Computational Modeling of Structurally Conserved Cancer Mutations in the RET and MET Kinases: The Impact on Protein Structure, Dynamics, and Stability
score: 2.8706832, Biophysical Journal, 2009, Dixit, Anshuman et. al.

Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in breast carcinomas in vivo.
score: 2.8702561, British journal of cancer, 1998, Barker, K T; Crompton, M R

Treatment in advanced colorectal cancer: what, when and how?
score: 2.8700597, British journal of cancer, 2009, Chau, I; Cunningham, D

Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation.
score: 2.8695856, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Landolfi, R; Di Gennaro, L; Falanga, A

Erythroblastic sarcoma
score: 2.8691, Leukemia Research, 2012, Riddle, Andrew; Olsen, Brian

Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations
score: 2.8688587, Experimental Hematology, 2007, Kancha, Rama Krishna et. al.

Targeting the RAF–MEK–ERK pathway in cancer therapy
score: 2.8688467, Cancer Letters, 2009, Montagut, Clara; Settleman, Jeff

Genes and chromosomes in chronic B-cell leukemia
score: 2.8686593, Cancer Genetics and Cytogenetics, 1997, Crossen, Peter E.

Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification.
score: 2.8686542, British journal of cancer, 2006, Tanaka, T et. al.

Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma.
score: 2.8670327, The Journal of pathology, 2008, Pan, C-C et. al.

Low frequency of p53 and ras mutations in bile of patients with hepato-biliary disease: a prospective study in more than 100 patients.
score: 2.8659958, European journal of clinical investigation, 2001, Müller, P et. al.

Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition
score: 2.8653554, The Journal of Experimental Medicine, 2012, Weigert, Oliver et. al.

Detection of rare mutant K- ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe
score: 2.8652655, Nucleic Acids Research, 2006, Luo, Ji-Dung et. al.

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies.
score: 2.8638273, Human molecular genetics, 2004, Storlazzi, Clelia T et. al.

Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis
score: 2.8635976, Biochemical and Biophysical Research Communications, 2008, Zhao, Yanhua et. al.

DNA analysis at p53 locus in carcinomas arising from pleomorphic adenomas of salivary glands: comparison of molecular study and p53 immunostaining.
score: 2.8629849, Pathology international, 1998, Yamamoto, Y et. al.

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
score: 2.8622979, BMC Cancer, 2008, Press, Joshua Z et. al.

Oncogenic mutations of ALK in neuroblastoma.
score: 2.862264, Cancer science, 2011, Ogawa, Seishi et. al.

Molecular Genetics and In Vitro Sensitivity of a New Human Cell Line, KKP, from a Gastric Adenocarcinoma
score: 2.86195, Cancer Genetics and Cytogenetics, 1998, Zoli, W et. al.

Role of inherited defects of MYH in the development of sporadic colorectal cancer.
score: 2.860985, Genes, chromosomes & cancer, 2004, Kambara, Takeshi et. al.

Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p.
score: 2.8602794, The Journal of investigative dermatology, 2001, Scarisbrick, J J et. al.

Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder.
score: 2.8597422, Cancer research, 2002, Hartmann, Arndt et. al.

The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.
score: 2.8589388, Oncogene, 2002, Nishimori, Hiroyuki et. al.

Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer
score: 2.8588528, Molecular Cancer, 2012, Nelson, Laura D et. al.

The Ews/Fli-1 fusion gene changes the status of p53 in neuroblastoma tumor cell lines.
score: 2.8584251, Cancer research, 2004, Rorie, Checo J; Weissman, Bernard E

Melanoma genetics: An update with focus on the CDKN2A(p16)/ARF tumor suppressors
score: 2.8582787, Journal of the American Academy of Dermatology, 2000, Piepkorn, Michael

ITD- and FL-induced FLT3 signal transduction leads to increased C/EBPbeta-LIP expression and LIP/LAP ratio by different signalling modules.
score: 2.8578516, British journal of haematology, 2010, Haas, Sandra C et. al.

Episodic Src activation in uveal melanoma revealed by kinase activity profiling.
score: 2.8577673, British journal of cancer, 2009, Maat, W et. al.

Detection of Clonal T-Cell Receptor γ Gene Rearrangements in Paraffin-Embedded Tissue by Polymerase Chain Reaction and Nonradioactive Single-Strand Conformational Polymorphism Analysis
score: 2.8546389, The American Journal of Pathology, 1999, Signoretti, Sabina et. al.

Accurate Detection of Uniparental Disomy and Microdeletions by SNP Array Analysis in Myelodysplastic Syndromes with Normal Cytogenetics
score: 2.8536728, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Heinrichs, Stefan et. al.

Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.
score: 2.8534566, Genes, chromosomes & cancer, 2000, Hilgers, W et. al.

Trisomy 5 as the sole chromosomal abnormality in a primary mucoepidermoid carcinoma of the minor salivary gland
score: 2.8529838, Cancer Genetics and Cytogenetics, 1994, El-Naggar, Adel K. et. al.

Pyrosequencing of BRAF V600E in routine samples of hairy cell leukaemia identifies CD5+ variant hairy cell leukaemia that lacks V600E.
score: 2.8523045, British journal of haematology, 2012, Lennerz, Jochen K et. al.

Profile of TP53 gene mutations in sinonasal cancer
score: 2.8521483, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2010, Holmila, Reetta et. al.

Mutations in the runt homology domain of CBFα2 in myeloid malignancies with acquired trisomy 21
score: 2.8520061, Cancer Genetics and Cytogenetics, 2002, Snaddon, Jennifer et. al.

A novel AKT3 mutation in melanoma tumours and cell lines.
score: 2.851489, British journal of cancer, 2008, Davies, M A et. al.

Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene.
score: 2.8514195, Cancer research, 1998, Tsao, H; Benoit, E; Sober, A J; Thiele, C; Haluska, F G

Absence of JAK-2V617F point mutations in multiple myeloma.
score: 2.8513945, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Huang, Q; Li, X; Chen, W; Weiss, L M

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.
score: 2.8508957, Cancer research, 2013, Tyner, Jeffrey W et. al.

Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer
score: 2.8499281, Surgery, 2002, Gervaz, Pascal et. al.

Application of molecular cytogenetic techniques in a case study of human cutaneous metastatic melanoma
score: 2.8491842, Cancer Genetics and Cytogenetics, 2001, Wiltshire, Rodney N et. al.

Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma.
score: 2.8490444, Oncogene, 2006, Sensi, M et. al.

PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer
score: 2.8487888, Clinical Colorectal Cancer, 2012, Sood, Arjun et. al.

Targeting BRAF in thyroid cancer
score: 2.8482932, British Journal of Cancer, 2006, Espinosa, A V; Porchia, L; Ringel, M D

Involvement of BH3-only proteins in hematologic malignancies
score: 2.8478904, Critical Reviews in Oncology and Hematology, 2009, Kuroda, Junya; Taniwaki, Masafumi

Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer.
score: 2.8477736, Human molecular genetics, 2005, Frigola, Jordi et. al.

Codon 12 Ki-ras mutation in non-small-cell lung cancer: comparative evaluation in tumoural and non-tumoural lung.
score: 2.8468844, British Journal of Cancer, 1996, Urban, T. et. al.

Translocations in epithelial cancers
score: 2.8455519, BBA - Reviews on Cancer, 2009, Brenner, J. Chad; Chinnaiyan, Arul M.

The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
score: 2.8449979, International journal of cancer. Journal international du cancer, 2008, Kim, Sol; Lee, Hye Jin; Jun, Hee Jung; Kim, Jungho

Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia
score: 2.8446742, British Journal of Cancer, 1999, Zhu, Y-M et. al.

Myeloproliferative disorders: premalignant, stem cell, G1 diseases?
score: 2.8440968, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2006, Lelièvre, H et. al.

p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway.
score: 2.8440787, Oncogene, 2012, Ozenne, P; Dayde, D; Brambilla, E; Eymin, B; Gazzeri, S

Leukocytosis is associated with poor survival but not with increased risk of thrombosis in essential thrombocythemia: a population-based study of 311 patients.
score: 2.8440128, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010, Girodon, F et. al.

Reviewing the somatic genetics of melanoma: from current to future analytical approaches.
score: 2.8436001, Pigment cell & melanoma research, 2012, Dutton-Regester, Ken; Hayward, Nicholas K

Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas
score: 2.8433571, British Journal of Cancer, 2009, Nakayama, S et. al.

Low microsatellite instability and high loss of heterozygosity rates indicate dominant role of the suppressor pathway in squamous cell carcinoma of head and neck and loss of heterozygosity of 11q14.3 correlates with tumor grade
score: 2.8401586, Cancer Genetics and Cytogenetics, 2003, Glavač, Damjan et. al.

Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, Greece
score: 2.8395346, Histopathology, 2006, Campo, E et. al.

TET2, a tumor suppressor in hematological disorders
score: 2.8392891, BBA - Reviews on Cancer, 2012, Mercher, Thomas et. al.

Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics
score: 2.839274, Biochemical Pharmacology, 2010, Woodman, Scott E.; Davies, Michael A.

Synergistic antitumor efficacy of sequentially combined paclitaxel with sorafenib in vitro and in vivo NSCLC models harboring KRAS or BRAF mutations
score: 2.8391377, Cancer Letters, 2012, Zhang, Xiang-Hua et. al.

TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients.
score: 2.8391271, Genes, chromosomes & cancer, 1996, Berns, E M et. al.

GENETIC MARKERS IN THYROID NEOPLASIA
score: 2.8385654, Endocrinology and Metabolism Clinics of North America, 2001, Puxeddu, Efisio; Fagin, James A.

A critical appraisal of conventional and investigational drug therapy in patients with hypereosinophilic syndrome and clonal eosinophilia.
score: 2.8380829, Cancer, 2007, Kalac, Matko et. al.

Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia
score: 2.8379876, British Journal of Cancer, 2011, Hou, H-A et. al.

Monitoring minimal residual disease with flow cytometry, antigen-receptor gene rearrangements and fusion transcript quantification in Philadelphia-positive childhood acute lymphoblastic leukemia
score: 2.8359805, Leukemia Research, 2009, Thörn, Ingrid et. al.

Tumor suppressor functions of FBW7 in cancer development and progression
score: 2.8348413, FEBS Letters, 2012, Wang, Zhiwei et. al.

Tumor suppressor functions of FBW7 in cancer development and progression
score: 2.8348413, FEBS Letters, 2012, Wang, Zhiwei et. al.

Tumor Suppressor Functions of FBW7 in Cancer Development and Progression
score: 2.8348413, FEBS Letters, 2012, Wang, Zhiwei et. al.

Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction.
score: 2.8342447, The American journal of gastroenterology, 2010, Ogino, Shuji et. al.

Point mutations of the BCL-6 gene: clinical and prognostic correlation in B-diffuse large cell lymphoma.
score: 2.834088, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002, Vitolo, U et. al.

Molecular Nevogenesis
score: 2.8338731, Dermatology Research and Practice, 2011, Ross, Andrew L.; Sanchez, Margaret I.; Grichnik, James M.

The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models.
score: 2.8336012, Molecular cancer therapeutics, 2012, Smyth, Tomoko et. al.

Epithelioid and sarcomatoid malignant pleural mesothelioma in endoscopic gastric biopsies: A diagnostic pitfall
score: 2.8331465, Pathology - Research and Practice, 2006, Agaimy, Abbas; Wünsch, Peter H.

Published guidelines versus real-life practice in the diagnosis and treatment of essential thrombocythemia.
score: 2.8331187, American journal of hematology, 2011, Peterson, Erica A et. al.

Serum- and glucocorticoid-regulated kinase 1 (SGK1) induction by the EWS/NOR1(NR4A3) fusion protein
score: 2.832832, Biochemical and Biophysical Research Communications, 2006, Poulin, Hugo et. al.

EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer
score: 2.832586, British Journal of Cancer, 2011, Ålgars, A et. al.

Cystic lesions of the pancreas.
score: 2.8313596, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2007, Volkan Adsay, N

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer
score: 2.8310459, British Journal of Cancer, 2001, Hawkins, N J; Tomlinson, I; Meagher, A; Ward, R L

A novel K509I mutation of KIT identified in familial mastocytosis—in vitro and in vivo responsiveness to imatinib therapy
score: 2.8309608, Leukemia Research, 2006, Zhang, Ling Yan et. al.

Molecular Phenotype of Inflammatory Bowel Disease-Associated Neoplasms With Microsatellite Instability
score: 2.8301308, Gastroenterology, 2005, Schulmann, Karsten et. al.

Loss of heterozygosity in follicular and papillary thyroid carcinomas
score: 2.8296674, Cancer Genetics and Cytogenetics, 2003, Rodrigues-Serpa, Ana; Catarino, Ana; Soares, Jorge

Five new cases of juvenile renal cell carcinoma with translocations involving Xp11.2
score: 2.8296317, Cancer Genetics and Cytogenetics, 2003, Pérot, Christine et. al.

Cowden's disease: clinical and molecular genetic findings in a patient with a novel PTEN germline mutation.
score: 2.8294942, The British journal of dermatology, 2003, Reifenberger, J et. al.

Identification of a HMGA2-EFCAB6 gene rearrangement following next-generation sequencing in a patient with a t(12;22)(q14.3;q13.2) and JAK2V617F-positive myeloproliferative neoplasm
score: 2.8288019, Cancer Genetics, 2012, Martin, S. Eric et. al.

Identification of a HMGA2-EFCAB6 gene rearrangement following next-generation sequencing in a patient with a t(12;22)(q14.3;q13.2) and JAK2V617F-positive myeloproliferative neoplasm
score: 2.8288019, Cancer Genetics, 2012, Martin, S. Eric et. al.

Analysis of IgV gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery.
score: 2.8286251, British journal of haematology, 2004, Degan, Massimo et. al.

EGFR gene copy number in adenocarcinoma of the lung by FISH analysis: Investigation of significantly related factors on CT, FDG-PET, and histopathology
score: 2.8282025, Lung Cancer, 2009, Park, Eun-Ah et. al.

Prognostic tissue markers in melanoma.
score: 2.8282012, Histopathology, 2012, Moore, David A; Pringle, J Howard; Saldanha, Gerald S

Absence of nucleophosmin leukaemic mutants in B and T cells from AML with NPM1 mutations: implications for the cell of origin of NPMc+ AML.
score: 2.8278075, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Martelli, M P et. al.

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways.
score: 2.8238579, Proceedings of the National Academy of Sciences of the United States of America, 1996, Carroll, M et. al.

The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53.
score: 2.8236748, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Drakos, E et. al.

Chromosomal abnormalities and microsatellite instability in sporadic endometrial cancer
score: 2.8234747, European Journal of Cancer, 2002, Muresu, R et. al.

Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma.
score: 2.821893, Cancer research, 2000, Gimm, O; Armanios, M; Dziema, H; Neumann, H P; Eng, C

Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis.
score: 2.8214579, Cancer research, 2007, Femia, Angelo Pietro et. al.

Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.
score: 2.8210206, Cancer research, 1999, Riemenschneider, M J et. al.

Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2.
score: 2.8197559, Cancer research, 1994, Reifenberger, G et. al.

The development of multiple bladder tumour recurrences in relation to the FGFR3 mutation status of the primary tumour.
score: 2.8195774, The Journal of pathology, 2009, Kompier, Lucie C et. al.

High resolution analysis of chromosome 18 alterations in ulcerative colitis-related colorectal cancer
score: 2.8193785, Cancer Genetics and Cytogenetics, 2002, Terdiman, Jonathan P et. al.

BCR-ABL1 kinase domain mutations: methodology and clinical evaluation.
score: 2.8187943, American journal of hematology, 2012, Alikian, Mary et. al.

Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis
score: 2.8187172, Oncogene, 2009, Lemjabbar-Alaoui, Hassan et. al.

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.
score: 2.8185912, Oncogene, 2009, Nikkilä, J et. al.

p53 mutations in tumors derived from irradiated human thyroid epithelial cells
score: 2.8179689, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999, Gamble, Simon C et. al.

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyosarcoma
score: 2.8170713, Cancer Genetics and Cytogenetics, 2005, Sandberg, Avery A.

Allelic loss of chromosome 17p, mutation of the p53 gene, and microsatellite instability in right- and left-sided colorectal cancer.
score: 2.8164938, Cancer, 1996, Watatani, M; Yoshida, T; Kuroda, K; Ieda, S; Yasutomi, M

Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.
score: 2.8161955, The Journal of investigative dermatology, 2009, Haferkamp, Sebastian et. al.

Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.
score: 2.8153358, Cancer research, 2001, Calvisi, D F; Factor, V M; Loi, R; Thorgeirsson, S S

CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutation
score: 2.8147877, British Journal of Cancer, 2001, Torre, G Della et. al.

Inborn and acquired metabolic defects in cancer
score: 2.8147487, Journal of Molecular Medicine (Berlin, Germany), 2011, Frezza, Christian; Pollard, Patrick J; Gottlieb, Eyal

Is there a prognostic role of K-ras point mutations in the serum of patients with advanced non-small cell lung cancer?
score: 2.81474, Lung Cancer, 2005, Camps, Carlos et. al.

Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regions
score: 2.8147365, Cancer Genetics and Cytogenetics, 2005, Chen, Ru et. al.

Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms.
score: 2.8145789, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2009, Wang, J et. al.

Further evidence for the lack of correlation between the breakpoint site within M- BCR and CML prognosis and for the occasional involvement of p53 in transformation
score: 2.8144575, Cancer Genetics and Cytogenetics, 1995, Aguiar, Ricardo C.T. et. al.

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas.
score: 2.8139363, Nature genetics, 2002, Kurose, Keisuke et. al.

Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.
score: 2.8124239, Cancer research, 1996, Reifenberger, G et. al.

Small Round Cell Sarcomas
score: 2.8123597, Seminars in Oncology, 2009, Lessnick, Stephen L. et. al.

B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas
score: 2.8116564, Human Pathology, 2006, Trovisco, Vítor; Soares, Paula; Sobrinho-Simões, Manuel

Transforming and Tumorigenic Activity of JAK2 by Fusion to BCR: Molecular Mechanisms of Action of a Novel BCR-JAK2 Tyrosine-Kinase
score: 2.8115936, PLoS ONE, 2012, Cuesta-Domínguez, Álvaro et. al.

The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.
score: 2.8102937, Oncogene, 2000, Wai, D H et. al.

Poor prognosis acute myelogenous leukemia: 1 – response to treatment with high dose cytarabine/mitoxantrone/ethyol @ (Amifostine)
score: 2.8102922, Leukemia Research, 2000, Preisler, Harvey D et. al.

Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas.
score: 2.8078596, Cancer research, 1995, Druck, T et. al.

Novel germline RET proto-oncogene mutations associated with medullary thyroid carcinoma (MTC): mutation analysis in Japanese patients with MTC.
score: 2.8070963, Oncogene, 1997, Kitamura, Y et. al.

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.
score: 2.806639, Cancer research, 1999, Fleisher, A S et. al.

Molecular testing in malignant melanoma.
score: 2.8065342, Diagnostic cytopathology, 2012, Grossmann, Allie H et. al.

Human Bladder Tumors With 2-Hit Mutations of Tumor Suppressor Gene TSC1 and Decreased Expression of p27
score: 2.8058579, The Journal of Urology, 2003, ADACHI, HIROYUKI et. al.

Integrated Genomic Analysis Implicates Haploinsufficiency of Multiple Chromosome 5q31.2 Genes in De Novo Myelodysplastic Syndromes Pathogenesis
score: 2.805747, PLoS ONE, 2009, Graubert, Timothy A. et. al.

Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients
score: 2.805678, Lung Cancer, 2012, Park, Heae Surng et. al.

Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients
score: 2.805678, Lung Cancer, 2012, Park, Heae Surng et. al.

Rare occurrence of p53 and ras gene mutations in preneoplastic and neoplastic mouse endometrial lesions induced by N-methyl- N-nitrosourea and 17β-estradiol
score: 2.804967, Cancer Letters, 1995, Murase, Toshiko et. al.

Classification of IVS1-10T →C as a Polymorphism of BRCA1
score: 2.8049281, Cancer Genetics and Cytogenetics, 1999, Fetzer, Sean et. al.

PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia
score: 2.8045425, Leukemia Research, 2007, Giles, Francis J. et. al.

Hotspot mutation of Brahma in non-melanoma skin cancer.
score: 2.8044399, The Journal of investigative dermatology, 2009, Moloney, Fergal J et. al.

A newly identified pattern of K-ras mutations at codons 12 and 13 is associated with long-term survival in colorectal cancer
score: 2.803634, Surgery, 1997, Senagore, Anthony J; Biener, Jennifer Thebo

Soft tissue tumors of the urinary bladder, part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential
score: 2.8033439, Human Pathology, 2007, Lott, Sarah et. al.

Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability.
score: 2.8026059, The Journal of pathology, 2006, Fujii, H et. al.

Molecular pathology of endometrial hyperplasia and carcinoma
score: 2.8022452, Human Pathology, 2001, Matias-guiu, Xavier et. al.

Inactivation of BHD in sporadic renal tumors.
score: 2.8021394, Cancer research, 2003, Khoo, Sok Kean et. al.

Detection of Mutant BRAF Alleles in the Plasma of Patients with Metastatic Melanoma
score: 2.8018542, The Journal of Molecular Diagnostics, 2007, Yancovitz, Molly et. al.

Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia.
score: 2.8005454, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Zebisch, A et. al.

Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.
score: 2.8004066, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007, Iqbal, J et. al.

Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica
score: 2.7997566, Cancer Letters, 2002, Chan, Jeannie et. al.

A frequent activated smoothened mutation in sporadic basal cell carcinomas.
score: 2.7995658, Oncogene, 1999, Lam, C W et. al.

p53 Rescue through HDM2 Antagonism Suppresses Melanoma Growth and Potentiates MEK Inhibition.
score: 2.7989723, The Journal of investigative dermatology, 2012, Ji, Zhenyu et. al.

Diagnosis and Classification of Small Round-Cell Tumors of Childhood
score: 2.7984229, The American Journal of Pathology, 1999, Ladanyi, Marc

Concordant CpG Island Methylation in Hyperplastic Polyposis
score: 2.7977149, The American Journal of Pathology, 2002, Chan, Annie On-On et. al.

Prognostic value of cetuximab-related skin toxicity in metastatic colorectal cancer patients and its correlation with parameters of the epidermal growth factor receptor signal transduction pathway: Results from a randomized trial of the GERMAN AIO CRC Study Group.
score: 2.7976855, International journal of cancer. Journal international du cancer, 2013, Stintzing, Sebastian et. al.

Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.
score: 2.7973038, Cancer research, 1998, Rhei, E et. al.

Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
score: 2.7970764, Genes, chromosomes & cancer, 2010, Ottaviano, Laura et. al.

The Ewing's sarcoma gene product functions as a transcriptional activator.
score: 2.7969853, Cancer research, 2001, Rossow, K L; Janknecht, R

The aberrant localization of oncogenic kit tyrosine kinase receptor mutants is reversed on specific inhibitory treatment.
score: 2.7968235, Molecular cancer research : MCR, 2009, Bougherara, Houcine et. al.

Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5
score: 2.7956685, Journal of Molecular Signaling, 2012, Kostenko, Sergiy; Dumitriu, Gianina; Moens, Ugo

Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated Src.
score: 2.7951087, The Journal of pathology, 2010, Sakuma, Yuji et. al.

Allelic imbalance at chromosome region 11q23 in cervical carcinomas
score: 2.7948235, European Journal of Cancer, 1999, Skomedal, H et. al.

Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours.
score: 2.794462, Oncogene, 1998, Fischer, J et. al.

Vascular tumors of the skin: A selective review
score: 2.7942492, Seminars in Diagnostic Pathology, 2004, Hunt, Steven J.; Santa Cruz, Daniel J.

Different gene expression profiles between microsatellite instability-high and microsatellite stable colorectal carcinomas.
score: 2.7937464, Oncogene, 2004, Kim, Hyunki et. al.

Differential distribution of CCDC26 glioma-risk alleles in myeloid malignancies with mutant IDH1 compared with their IDH2R140-mutated or IDH-unmutated counterparts.
score: 2.7932008, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2012, Lasho, T L et. al.

Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer.
score: 2.7930984, Oncogene, 2004, Shan, Zhihong; Parker, Tracy; Wiest, Jonathan S

Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations
score: 2.7925823, The Journal of Allergy and Clinical Immunology, 2012, Broesby-Olsen, Sigurd et. al.

Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations
score: 2.7925823, The Journal of Allergy and Clinical Immunology, 2012, Broesby-Olsen, Sigurd et. al.

Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma.
score: 2.7912172, Cancer research, 2003, Spugnardi, Mia et. al.

Hemochromatosis-associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts.
score: 2.7909914, American journal of hematology, 2007, Nearman, Zachary P et. al.

Epidermal Growth Factor Receptor Targeting in Cancer
score: 2.7909498, Seminars in Oncology, 2006, Mendelsohn, John; Baselga, Jose

Targeting BRAF in thyroid cancer.
score: 2.7906361, British journal of cancer, 2007, Espinosa, A V; Porchia, L; Ringel, M D

Genome-wide DNA-mapping of CD34+ cells from patients with myelodysplastic syndrome using 500K SNP arrays identifies significant regions of deletion and uniparental disomy
score: 2.7903396, Experimental Hematology, 2009, Nowak, Daniel et. al.

Real-time reverse transcription PCR and the detection of occult disease in colorectal cancer
score: 2.7900435, Molecular Aspects of Medicine, 2006, Bustin, Stephen A.; Mueller, Reinhold

A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma.
score: 2.7896702, British Journal of Cancer, 1997, Ohnishi, T. et. al.

CNS young investigator award lecture: Molecular analysis of the neurofibromatosis 2 tumor suppressor
score: 2.7895113, Brain and Development, 1995, MacCollin, Mia

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo
score: 2.7884605, British Journal of Cancer, 2010, Lamont, F R et. al.

Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.
score: 2.7883497, Cancer research, 1991, Candrian, U et. al.

The impact of a high-frequency microsatellite instability phenotype on the tumor location-related genetic differences in colorectal cancer
score: 2.7882543, Cancer Genetics and Cytogenetics, 2010, Zhao, Yan et. al.

Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.
score: 2.7881357, British journal of cancer, 1995, McCann, A H et. al.

Colorectal Cancer Expression of Peroxisome Proliferator-Activated Receptor γ (PPARG, PPARgamma) Is Associated With Good Prognosis
score: 2.7879574, Gastroenterology, 2009, Ogino, Shuji et. al.

p53 in a Thyroid Follicular Carcinoma with Foci of Poorly Differentiated and Anaplastic Carcinoma
score: 2.7872727, Pathology - Research and Practice, 1996, Matias-Guiu, X. et. al.

Choosing between stem cell therapy and drugs in myelofibrosis.
score: 2.7871439, Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008, Kröger, N; Mesa, R A

Severe polyposis in Apc 1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5
score: 2.7866821, Gut, 2010, Lewis, Annabelle et. al.

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.
score: 2.7863463, Oncogene, 1998, Birch, J M et. al.

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors
score: 2.7859868, Cancer Genetics and Cytogenetics, 2002, Sandberg, Avery A; Bridge, Julia A

Lack of germ-line mutations in the p53 gene exons 4 to 8 in patients with late-onset second malignant neoplasms
score: 2.7857119, Cancer Genetics and Cytogenetics, 1994, Lalle, Philippe; Moyret, Caroline; Bignon, Yves-Jean

Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region.
score: 2.7856375, British journal of cancer, 1995, Leggett, B et. al.

Genomic instability and p53 alterations in patients with malignant glioma
score: 2.7855183, Experimental and Molecular Pathology, 2012, Milinkovic, Vedrana et. al.

Genomic instability and p53 alterations in patients with malignant glioma
score: 2.7855183, Experimental and Molecular Pathology, 2012, Milinkovic, Vedrana et. al.

Analysis of succinate dehydrogenase subunit B gene alterations in gastric cancers.
score: 2.7853335, Pathology international, 2010, Cao, Zhang et. al.

Alterations of the insulin-like growth factor system in patients with polycythemia vera
score: 2.7846493, Molecular and Cellular Endocrinology, 2001, Michl, P.; Spoettl, G.; Engelhardt, D.; Weber, M.M.